EQUINA: A CT SCANNER DESIGNED - BY AND FOR VETERINARIANS - Asto CT

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EQUINA: A CT SCANNER DESIGNED - BY AND FOR VETERINARIANS - Asto CT
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                      EQUINA™: A CT SCANNER DESIGNED
                          BY AND FOR VETERINARIANS

   December 20, 2018

                                         Asto CT LLC
                  Asto CT                3300 Commercial Ave, Madison, WI 53714
                                         www.AstoCT.com
                    Equine Standing CT

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EQUINA: A CT SCANNER DESIGNED - BY AND FOR VETERINARIANS - Asto CT
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Changing the paradigm in equine imaging
                               Current imaging tools are not
          The
                               sufficient to optimally manage
        Problem
                               equine patients

                               EquinaTM is a CT system that
       Asto CT
                               allows imaging of a standing
      Technology
                               sedated horse

                               Enable veterinarians to broadly
        Our Goal               offer CT imaging to the equine
                               community

                   Asto CT has pioneered standing CT to provide state-of-the-art
                          screening & diagnosis to equine veterinarians
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EQUINA: A CT SCANNER DESIGNED - BY AND FOR VETERINARIANS - Asto CT
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Acquiring CT images is a simple process

                   Lead horse             Position           Reverse
     Step          to 75cm         Step   scanner &   Step   sedation &
      1            target ring &
                   sedate
                                    2     acquire
                                          images
                                                       3     lead horse
                                                             off platform

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EQUINA: A CT SCANNER DESIGNED - BY AND FOR VETERINARIANS - Asto CT
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Equina™ in action
   “We’ve been waiting a long time to go
   from CT under general anesthesia to CT                     “We’ve been waiting a long time to go
   standing... This is going to open it up in                 from CT under general anesthesia to CT
   terms of cost, and additionally it’s going                 standing... This is going to open it up in
   to open it up to many more practices
                                                              terms of cost, and additionally it’s going
   who don’t have facilities to do general
                                                              to open it up to many more practices
   anesthesia.”
                                                              who don’t have facilities to do general
                                                              anesthesia.”
                                                                        -   Carl Kirker-Head
                                                                            Orthopedic & Large Animal Surgeon

   To see the Equina in action, view this short video clip:
   https://youtu.be/pdUHwPPPOKw
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EQUINA: A CT SCANNER DESIGNED - BY AND FOR VETERINARIANS - Asto CT
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Equina™ enhances your equine practice
                                Performance horses
                                Early detection of stress fractures
                                Effectively manage training programs

                                  Show & Recreation
                                  Easier identification and management of lameness & other
                                  musculoskeletal concerns

                                Older horses
                                Best-in-class diagnosis of dental & sinus problems

                         Equina™ can help you to manage a wide range of
                                conditions in your equine patients
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EQUINA: A CT SCANNER DESIGNED - BY AND FOR VETERINARIANS - Asto CT
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Siting requirements – built-in system
Example 18’ x 16’ room                                           Limb scan

                                         10’-3”

                               26-inch access floor door

                       12’                Equine           16’   Head scan
                                           CT

                               18-inch access floor door

                                   18’

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EQUINA: A CT SCANNER DESIGNED - BY AND FOR VETERINARIANS - Asto CT
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Siting requirements – free-standing system
Example staging area, ramp, and stairs

                                           Stairs

                                                              Staging area    4’
                    22’-6”

                                                         4’

                                                               14’
                                             4’

                                                              14’
                               6’   Ramp                            Equine    8’
                                                                                   8’-4”

                                                                     CT

                                              22’-6”
                                     12’            8’                   8’

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Performance meets key equine needs                                      Asto CT Equina Specifications
                                                 Base System / Motion Assembly
                                                   Width (base)                                    254 cm (100 in)

§   Flexible imaging                               Length (base)

                                                   Height (uprights)
                                                                                                   239 cm (94 in)

                                                                                                   371 cm (146 in)

                                                   Gantry pitch range                              0 to 90°

    § 30” (75 cm) opening and field of view (FOV) for easy
                                                   Total vertical motion range                     228 cm (90 in)

                                                   Continuous scan field (limb & head scans)       100 cm (40 in)
                                                                                                                                                                           Safe, Simple, Standing CT
                                                                                                                                                                     Changing the paradigm in equine imaging
     positioning of horse within target ring
                                                                                                   1,364 kg (3000lbs) – optimized to withstand
                                                   Max strike force to gantry/pedestal
                                                                                                   impact of startled horse
                                                 Electrical Service                                208-240 V Single Phase; 30 A

                                                 CT Gantry
                                                                                                                                                  Asto CT Equina Specifications

    § Simultaneous imaging of two legs
                                                   Gantry opening (bore diameter)                  75 cm (30 in)
                                                                                                                           Base System / Motion Assembly
                                                                                                                               Widthgantry
                                                                                                   75 cm (30 in) – everything within  (base)                                254 cm (100 in)                                Simple
                                                   Nominal field of view (FOV)
                                                                                                   opening is scanned
                                                                                                                               Length (base)                                239 cm (94 in)
                                                   Scan time for a full 360° rotation              1 sec

§   Simple push button control for setup & scanning
                                                                                                                               Height (uprights)                            371 cm (146 in)
                                                   Number of detector rows                         24
                                                                                                                               Gantry pitch range                           0 to 90°                                       Rugged
                                                   Helical pitch                                   Variable (typical = 0.55)
                                                                                                                               Total vertical motion range                  228 cm (90 in)
                                                   Helical scan velocity                           Variable (typical = 2 cm/sec)
                                                                                                                               Continuous scan field (limb & head scans)    100 cm (40 in)
                                                                                                                                                                                                                                      Safe, Sim
    Wide scan ranges
                                                   Slice acquisition rate                          36 slices/sec
                                                                                                                                                                                                                                Changing the
§
                                                                                                                                                                            1,364 kg (3000lbs) – optimized to withstand
                                                                                                                               Max strike force to gantry/pedestal
                                                 Free-standing Platform (Optional)                                                                                          impact of startled horse                      Diagnostic
                                                   Surface
                                                                                                                           Electrical Service
                                                                                                   Non-slip, shock-absorbing, washable
                                                                                                                                                                            208-240 V Single Phase; 30 A

                                                   Ramp                                            Detachable,
EQUINA: A CT SCANNER DESIGNED - BY AND FOR VETERINARIANS - Asto CT
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Advantages of new industrial CT technology
§   High-quality imaging
    § Fast acquisition (1 sec per rotation)
    § 0.75mm resolution
    § Variable helical pitch (typical = 0.55)
    § 24 detector rows
    § 36 slices/sec acquisition rate
    § Optional dual-energy imaging

§   Rugged design
    § Water-cooled, sealed gantry
    § Designed to withstand the strike force from
     a startled horse

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  Images demonstrate diagnostic quality
                                                                             Left

                                                                             Right

                                                 2D MPR → navicular
                                                disease in left front foot

                                                               Enhanced detail with 2x dose
        3D MPR of thoracic limbs & localizers

Irregular surface
of tarsal bones &
volumetric model
→ spavin

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  Flexibility for diagnosis of head & sinus problems

                                                                Reconstruction
                                                                → pulp cavities
                                                                in cheek teeth

                                                                                  Image of vertebral
                                                                                  bone and spine cord
3D MPR of Head and Neck → diagnostic image of sinuses & teeth

  Proprietary and Confidential
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Equina™ can be used for small animals

§   Flexibility of robotics can
    accommodate a gurney for small
    animals
§   The gurney is stationary à
    convenient for simultaneous use of
    anesthesia equipment & other
    apparatus

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1st Equina™ – UW School of Veterinary Medicine
§   Commissioned on Nov 24, 2018
§   Building image database across key
    equine patient segments
§   Evaluating clinical cases – Equina
    identifies more pathology than x-rays
§   Establishing value of Equina – access
    to limbs with breakdown injuries

            To see the Equina at the UW SVM:
               https://youtu.be/Q7lK9htHtiA

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About Asto CT
§   Asto CT was founded in 2015 as a result of a research collaboration between
    the UW-Madison School of Veterinary Medicine (Peter Muir) and Morgridge
    Institute for Research (Rock Mackie)
§   The company has pioneered robotics in combination with CT scanning to
    provide new imaging indications
§   Our patented approach allows for imaging of a standing sedated horse, or
    small animals on a mobile gurney
§   The first mission is to improve diagnosis and treatment of conditions of the
    distal limb and diseases of head & neck in horses

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World-class team & advisors

                                                         Technology
                        David Ergun     Rock Mackie      Leadership   Olof Johnson Regina Fulkerson
                        Founder, CEO    Founder, Chair                Chief Engineer, Medical Physics
                                                                      President, PDSI

    Peter Muir                                                                                          Harry Freeman
    Founder, CMO                                                                                        Chief Commercial
    UW Vet School                                                                                       Officer

                                           Equine                 Commercial
                                          Knowledge                Success
                        Mark Markel                                                    Megan Rothney
                        Founder,                                                       Marketing
                        UW Vet School
    Sabrina Brounts                                                                                     Cristina Ergun
    Equine Specialist                                                                                   Veterinarian
    UW Vet School
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Summary
§   Asto CT technology is shifting the paradigm in equine
    imaging by solving long-standing diagnostic problems
§   Equina™ offers safe, high-quality CT imaging to the
    equine community
§   Equina™ is a versatile system that can be used for small
    animals
§   Flexible purchase terms to meet customer needs

         Please join our race to end equine fractures!

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Asto CT

                           Preventing equine fractures with
                            safe, high-quality CT imaging
Proprietary and Confidential
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