Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables February 11, 2021 - Ontario COVID-19 Science ...
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Key Findings • Public health measures are paying off in declining mobility, cases, positivity, and hospitalizations. • Focussing vaccination on long-term care homes is paying off with declining daily deaths. • ICU occupancy is flat and the access to care deficit continues to grow. • The B.1.1.7 Variant of Concern is spreading. Cases will likely grow again in late February with ICU admissions increasing afterwards. • Aggressive vaccination and sticking with stay-at-home order will help avoid a third wave and a third lockdown. • Some key mental health indicators are unchanged. However, important measures such as emergency department admissions, opioid deaths and care for eating disorders are worsening. 2
Cases and percent positivity declined across age groups. 6
Cumulative COVID-19 vaccine dose administrations (426,834 doses to Feb 10, 2021) Vaccine dose administrations Current status Cumulative COVID-19 Vaccinations Since December 15, 2020, 426,834 450 426,834 Thousands vaccine dose administrations have 400 been reported in COVax. 350 These administrations include Pfizer 300 and Moderna vaccines. Doses Administered 250 92% of vaccine administrations have 200 been since Jan 1, 2021. 150 100 50 0 01-Feb 03-Feb 05-Feb 07-Feb 09-Feb 15-Dec 17-Dec 19-Dec 21-Dec 23-Dec 25-Dec 27-Dec 29-Dec 31-Dec 02-Jan 04-Jan 06-Jan 08-Jan 10-Jan 12-Jan 14-Jan 16-Jan 18-Jan 20-Jan 22-Jan 24-Jan 26-Jan 28-Jan 30-Jan 2020 2021 Source: COVAX Data Source: COVax. Data to Jan 22nd extracted from COVax Dose Admin by Day Report. Jan 23rd-Feb 7th: COVax daily reports (Health Data Branch, MOH). Includes Pfizer and Moderna vaccines. Excludes records where status is not known. 7
The majority of deaths arise from long-term care. Analysis: COVID-19 ModCollab. 8 Data: CCM+
Long-term care key indicators improved. COVID-19 cases and deaths for LTC residents and staff Current status 2000 213 LTC homes have COVID-19 1800 Daily Active Cases Residents outbreaks (34% of all homes) 1600 Daily Active Cases Staff with 90 outbreaks involving 1400 Cumulative deaths since Sept 1 resident cases. 1200 25 of 34 PHUs have at least 1 1000 home in outbreak. 800 600 Since January 900 LTC 1st 400 residents and 3 staff have died of COVID-19. Wave 2 200 deaths (1,821) now roughly 0 Sep Sep Oct Oct Nov Nov Dec Dec Jan 15- 01- equal to Wave 1 (1,848). 1 15 1 15 1 15 1 15 1 Jan Feb Data Source: Ministry of Long Term Care Tracker, Feb 8th extraction based on data reported up to 3:30 pm Feb 7th, 2021. Data are self-reported by the long-term care homes to the Ministry of Long-Term Care. Daily case and death figures may not immediately match the numbers posted by the local public 9 health units (i.e. iPHIS database) due to lags in reporting time.
Hospitalizations dropped and ICU occupancy stabilized. 2,000 1,900 1,800 1,700 Confirmed COVID-19 Acute Inpatients (excluding ICU) 1,600 Confirmed COVID-19 ICU Patients 1,500 1,400 1,300 1,200 1,100 1,000 900 800 700 600 500 400 300 200 100 0 10 Data Sources: Daily Bed Census Summary COVID-19 Report + Critical Care Information System. Extracted via MOH SAS VA February 9, 2021. Does not include patients in alternative health facilities (AHFs)
The highly transmissible B.1.1.7 variant will soon dominate. • Variants are likely between 5% and 10% of cases now. • To prevent an increase in total cases Re for B.1.1.7 needs to be below 0.7. • Current Re is between 0.8 and 0.9, it has only approached 0.7 once. • Public Health Measures appear to be effective against all variants. • First cases of B.1.351 (detected in South Africa) and P.1 (detected in Brazil) detected in Ontario. 11 Predictions: QueensU
To control growth with variants, we must push R to 0.7 Toronto Forecast OV R = 0.7 1800 1600 1400 1200 Daily Counted Cases Observed Cases 1000 Old Variant (Estimated) New Variant (Estimated) 800 Forecast OV R = 0.7 600 OV Forecast (R = 0.7) NV Forecast (R = 0.98) 400 200 0 15-Dec-20 04-Jan-21 24-Jan-21 13-Feb-21 05-Mar-21 25-Mar-21 14-Apr-21 Predictions: DLSPH 12
At R=0.9 (just above current) variant triggers exponential growth Toronto Forecast OV R = 0.9 1800 1600 1400 1200 Daily Counted Cases Observed Cases 1000 Old Variant (Estimated) New Variant (Estimated) 800 Forecast OV R = 0.9 600 OV Forecast (R = 0.9) NV Forecast (R = 1.26) 400 200 0 15-Dec-20 04-Jan-21 24-Jan-21 13-Feb-21 05-Mar-21 25-Mar-21 14-Apr-21 13 Predictions: DLSPH
If public health measures are lifted, cases could rise dramatically depending on spread of B.1.1.7. Daily Cases 20,000 18,000 16,000 14,000 12,000 10,000 8,000 6,000 4,000 2,000 - 01-01 01-03 01-05 01-07 01-09 01-11 01-13 01-15 01-17 01-19 01-21 01-23 01-25 01-27 01-29 01-31 02-02 02-04 02-06 02-08 02-10 02-12 02-14 02-16 02-18 02-20 02-22 02-24 02-26 02-28 03-02 03-04 03-06 03-08 03-10 03-12 03-14 03-16 03-18 03-20 03-22 03-24 03-26 03-28 03-30 ON - Daily ON - 7-Day Mean ON 5%↓ Low Medium High Predictions informed by modeling from COVID-19 ModCollab, McMasterU, QueensU, YorkU; recent decrease in new daily cases 14 Data (Observed Cases): covid-19.ontario.ca
The majority of ICU admissions arise outside of long-term care homes. Analysis: COVID-19 ModCollab. 15 Data: CCM+
ICU Occupancy will follow changes in case rates by two weeks. Growth could start as early as the second week in March. ICU Occupancy 700 600 500 400 300 200 100 0 01-01 01-03 01-05 01-07 01-09 01-11 01-13 01-15 01-17 01-19 01-21 01-23 01-25 01-27 01-29 01-31 02-02 02-04 02-06 02-08 02-10 02-12 02-14 02-16 02-18 02-20 02-22 02-24 02-26 02-28 03-02 03-04 03-06 03-08 03-10 03-12 03-14 03-16 03-18 03-20 03-22 03-24 03-26 03-28 03-30 ON Observed ON Predicted Low High Medium Capacity Threshold Predictions: COVID-19 ModCollab. 16 Data (Observed ICU Occupancy): CCSO
The impact of the Pandemic has been inequitable and will continue to be inequitable Analysis: COVID Heterogeneity Research Group 17 Data: ICES
Mental health medication dispensing has been stable Individuals dispensed benzodiazepines (per 1,000 population) [ICES data] WHO pandemic declaration Analysis: ODPRN 18 Data: ICES data is updated quarterly, with up to a 3 month reporting lag
Emergency department visits for mental health and addictions care have declined 30% WHO pandemic Mental Health-related ED visits Substance Use-related ED visits declaration 20% 10% 6% 0% -2% Percent -10% -15% -20% -17% -30% -38% -40% -43% -50% 2020-02-23 2020-03-23 2020-04-23 2020-05-23 2020-06-23 2020-07-23 2020-08-23 2020-09-23 2020-10-23 2020-11-23 2020-12-23 2021-01-23 Analysis: OH MHA Centre of Excellence 19 Data: Electronic Canadian Triage and Acuity Scale (eCTAS)
Overdose deaths have continued to climb WHO pandemic declaration Notes: Data provided by the office of the Chief Coroner of Ontario (OCC); Suspect drug-related deaths are identified based on preliminary information reported by the investigating coroners to the office of the Chief Coroner of Ontario. It takes several months for these investigations to be completed and acute drug toxicity deaths to be confirmed; Opioid- related deaths includes confirmed and probable, and are considered preliminary; Once investigations are complete, acute opioid toxicity is typically deemed to be at least one of Analysis: ODPRN 20 the substances directly contributing to about 65%-80% of suspected-drug related deaths (depending on the time period) Data: Chief Coroner of Ontario
Eating disorder visits and admissions have increased. Hospitalizations and emergency department visits* for eating disorders among children and adolescents (3 to 17 years) in Ontario by 4-week average, Jan 2017 to Sept 2020 Emergency department visits Hospitalizations 3.5 3 Crude rate per 100,000 population 2.5 2 1.5 1 0.5 0 Apr-17 Jan-17 Mar-17 Oct-17 Apr-18 Jul-17 Oct-18 Aug-17 Jan-18 Mar-18 Apr-19 Oct-19 Jun-17 Jul-18 Aug-18 Jan-19 Mar-19 Apr-20 Jun-18 Jul-19 Aug-19 Jan-20 Mar-20 May-17 Jun-19 Jul-20 Aug-20 Jun-20 Feb-17 Sep-17 Dec-17 May-18 Nov-17 Feb-18 Sep-18 Dec-18 May-19 Nov-18 Feb-19 Sep-19 Dec-19 May-20 Nov-19 Feb-20 Sep-20 4-week average Analysis: OH MHA Centre of Excellence 21 Data: ICES)
Key Findings • Public health measures are paying off in declining mobility, cases, positivity, and hospitalizations. • Focussing vaccination on long-term care homes is paying off with declining daily deaths. • ICU occupancy is flat and the access to care deficit continues to grow. • The B.1.1.7 Variant of Concern is spreading. Cases will likely grow again in late February with ICU admissions increasing afterwards. • Aggressive vaccination and sticking with stay-at-home order will help avoid a third wave and a third lockdown. • Some key mental health indicators are unchanged. However, important measures such as emergency department admissions, opioid deaths and care for eating disorders are worsening. 22
Contributors • COVID Heterogeneity Research Group: Rafal Kustra, Huiting Ma, Siyi Wang, Gary Moloney, Kristy Yiu, Beate Sander, Jeff Kwong, Stefan Baral, Sharmistha Mishra • COVID-19 Modeling Collaborative: Kali Barrett, Stephen Mac, David Naimark, Aysegul Erman, Yasin Khan, Raphael Ximenes, Sharmistha Mishra, Beate Sander • DLSPH: Ashleigh Tuite, David Fisman • Fields Institute: Kumar Murty • QueensU: Troy Day • McMasterU: Michael Li, Irena Papst, Ben Bolker, Jonathan Dushoff, David Earn • YorkU: Jianhong Wu, Francesca Scarabel, Bushra Majeed • MOHLTC: Michael Hillmer, Kamil Malenvov, Qing Huang, Jagadish Rangrej, Nam Bains, Jennifer Bridge • OH: Erik Hellsten, Stephen Petersen, Anna Lambrinos, Chris Lau, Access to Care Team, Michelle Rossi, Paul Kurdyak (also DLSPH and CAMH) • ODPRN: Tara Gomes • PHO: Sarah Buchan, Kevin Brown 23
Content provided by Modelling Consensus and Scientific Advisory Table members and secretariat Beate Sander,* Peter Juni, Brian Schwartz,* Kumar Murty,* Upton Allen, Vanessa Allen, Nicholas Bodmer, Isaac Bogoch, Kevin Brown, Sarah Buchan, Yoojin Choi, Troy Day, David Earn, Gerald Evans, David Fisman, Jennifer Gibson, Anna Greenberg, Anne Hayes, Michael Hillmer, Jessica Hopkins, Jeff Kwong, Audrey Laporte, John Lavis, Gerald Lebovic, Brian Lewis, Linda Mah, Kamil Malikov, Antonina Maltsev, Doug Manuel, Allison McGeer, David McKeown, John McLaughlin, Sharmistha Mishra, Justin Morgenstern, Samira Mubareka, Laveena Munshi, Christopher Mushquash, Ayodele Odutayo, Shahla Oskooei, Samir Patel, Bill Praamsma, Justin Presseau, Fahad Razak, Rob Reid, Paula Rochon, Laura Rosella, Arjumand Siddiqi, Chris Simpson, Arthur Slutsky, Janet Smylie, Nathan Stall, Ashleigh Tuite, Jennifer Walker, Tania Watts, Ashini Weerasinghe, Scott Weese, Xiaolin Wei, Jianhong Wu, Diana Yan, Emre Yurga * Chairs of Scientific Advisory or Modelling Consensus Tables 24
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