SBHSE Biomedical Engineering Symposium - Fall 2017
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SBHSE School of Biological and
Health Systems Engineering
Biomedical Engineering
Symposium
Fall 2017
1
page
Table of Contents 29. CranioSure: Non-Invasive, ICP-Based Risk Assessment Device 16
30. Patient Warming System for Use in Spinal Surgery 16
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31. Advanced Wound Reading Technology 17
Welcome 4 32. Early Detection and Diagnosis Stent for Acute Myocardial Infarction . 17
Acknowledgements 5 33. Duodetect: Multi-Marker Sensor Capable of Simultaneous Detection of Insulin and Glucose
for Patients with Diabetes Mellitus 18
BME Capstone Projects 34. Positive Expiratory Pressure Device with Temporal Monitor 18
35. EZ Tilt: A Pediatric CT Head Holder Designed to Reduce Radiation Exposure 18
36. Transcutaneous Trigeminal Neurostimulator 19
1. Viragel: An Adenovirus Delivery System for Treating Hepatocellular Carcinoma 6 37. Epidural Fibrosis Cutting Device 19
2. Critical Care Compact IV Pump 6 38. Wearable Range of Motion Measuring Device 19
3. NormaTherm: Surgical Patient Temperature Management System 6 39. Partial Weight Bearing Monitor for Physical Therapy Rehabilitation 20
4. Sleep Switch The Original Circadian Metronome™ 7 40. Continuous Fall Monitoring and Prevention Stabilizing Exoskeleton 20
5. Enhanced Laminectomy Excision Device (ELED) 7 41. Wearable Maternity Support Belt With a Monitoring System 20
6. CryoRelease: Temperature Regulating Dynamic Splint for Spasticity Relief 8 42. Breathe EZ - Motorized Controllable Intubation Stylet 21
7. Alzheimer’s Monitoring and Alert Wearable 8 43. Spinal Deviation Diagnostic System 21
8. ClariVision: Endoscopic Lens Self-Cleaning System 8 44. PremaKare - Wireless Monitoring of Preterm and Low-Birth Weight Infants under Kangaroo Mother Care 22
9. Cervical Collar With Detachable Jaw Piece 9 45. Measureless Vision: Smart White Cane 22
10. EsophaCool: A Thermoregulatory Device for the Monitoring and Cooling of the Esophagus
during Cardiac Ablation Procedures 9
11. Stethosound: A Combination Ultrasound Stethoscope Device 9 Masters Applied Projects
12. Ventriculoperitoneal Shunt Distal Catheter Retainment Device 10
13. Breast Microcalcification Biosensor 10
1. Analysis of sEMG Data from Testing Participants Wearing a Soft Inflatable Exosuit on the Lower Limbs 23
14. The Nitpick: A Micro-Machined Apparatus for the Treatment of Pediculosis 11
2. Investigating the Neural Characteristics of Motor Learning in the Time-Frequency Domain 23
15. Wearable Blood Pressure Sensor Employed to Detect Preeclampsia 11
3. Continuous Wearable Health Monitoring Device to Reduce Hospital Readmission Rates 23
16. Optimization of a HDACi-Loaded PLA-PEG Nanoparticle for the Treatment of TBI 11
17. I-CON: Ocular Tracking Device for Traumatic Brain Injury 12 4. Impedance Mapping of an Ex-Vivo Rat Nerve 24
18. Outpatient Wearable Technologies: A Wearable Optical Sensor for Non-Invasive Respiration 5. Improving Osteogenesis and Mineralization within Diabetic In Vitro Cell Culture Models 24
Rate Monitoring 12 6. Development of an Automated Metabolomics Workflow to Achieve Omics Integration for
19. Integrated Bioinformatics for Orthopedic Braces 12 Molecular Phenotyping 24
20. User-Centric, Modular-Component Dog Prosthesis 13
7. Sex Implications on the Neuroinflammatory Response Resulting from Traumatic Brain Injury 25
21. SpineAlign: Scoliosis Intraoperative Load Sensor 13
8. The Effect of Perturbation Training on The Reorganization of Gait by Measure of Local Dynamic Stability 25
22. BRiCS: Cell Isolation and Addressing System 13
9. Do Clearing Agents Used in Decellularization Make a Difference in Adm Properties? 26
23. Adjustable Percutaneous Transluminal Angioplasty Balloon Catheter 14
10. Gender Differences in Human Ankle Stiffness 26
24. Hydra Cell: Engineered Electroreceptive Cell for Brain Computer Interfacing 14
25. EndoViper: Upper Gastrointestinal Foreign Body Extractor 14 11. Construction of an Artificial Bladder 27
26. Mechanical Transtibial Prosthetic Device 15 12. Analysis of Current Quality Standards in Biomanufacturing of Specialized 3D Tissue and Organ
27. Stroke Induced Hemiparesis Rehabilitation Device 15 Systems to Evaluate the Technical and Economic Feasibility of Advanced Biomanufacturing Concepts 27
28. A Locking Cap for Spine Fixation 16
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Welcome Capstone Teaching Assistants
Chi-En Lin, MS Candidate
Dr. Rosalind Sadleir, Asst. Professor, SBHSE
Mr. Edgar Sanchez Garcia, CR Bard, Inc
Cory Riecken, PhD Candidate Dr. Marco Santello, Director & Professor, SBHSE
On behalf of the students, staff, faculty and affiliated colleagues of the School of Dr. Sydney Schaefer, Asst. Professor, SBHSE
Biological and Health Systems Engineering, one of the six schools in the Ira A. Fulton
Facilitators Dr. Sylvain Sidi, Banner Desert Medical Center
Hany Arafa, MS Candidate Mr. Brandon Simmons, CR Bard, Inc
Schools of Engineering at Arizona State University and the Harrington Bioengineering
Samantha Brenna, MS Candidate Dr. Rachael Sirianni, Barrow Neurological Institute
Program along with our clinical and industrial partners, it is our pleasure to once
David Probst, MS Candidate Dr. Barbara Smith, Asst. Professor, SBHSE
again welcome you to our annual design symposium. Proudly displayed before you
Francis Taguinod, MS Candidate Dr. Aijaz Sofi, Arizona Center for Digestive Health
in this annual symposium are the collective creative outcomes developed by our
Nicholas Walker, Equipment Safety Assistant Dr. Sarah Stabenfeldt, Assoc. Professor, SBHSE
biomedical engineering senior capstone designers and masters applied project
candidates that exemplify this culminating event. It is a testament to the wide range Dr. Joel Strom, University of South Florida School of Medicine
Design Studio Staff
of expertise provided by our dedicated mentors and professional staff who, year in Dr. Justin Tanner, Postdoc Research Asoc., SBHSE
Michael Sobrado, Lab Coordinator Sr. Dr. Xiaojun Tian, Asst. Professor, SBHSE
and year out, support the next generation of biomedical engineering scientists and Marco Santello, PhD
designers who are expected to solve the pressing global grand challenges in health Director, SBHSE Dr. Jamie Tyler, Assoc. Professor, SBHSE
Faculty and Mentors
care. In addition, with an intensifying culture of innovation continuing to emerge at Harrington Endowed Dr. Michael VanAuker, Lecturer, SBHSE
Dr. James Abbas, Assoc. Professor, SBHSE
ASU and within the greater Arizona community, the growing entrepreneurial spirit Chair & Professor Dr. Brent Vernon, Assoc. Professor, SBHSE
Mr. Abdulrahman Alshareef, CIDSE
will continue to provide unprecedented opportunities to our biomedical engineering Dr. Xiao Wang, Assoc. Professor, SBHSE
Dr. Bruno Azeredo, Asst. Professor Polytechnic Campus
students who will have acquired the skill sets to become the next generation Mr. Ron Whiteside, Hanger
Dr. Dianna M.E. Bardo, Phoenix Childrens Hospital
of health care technology leaders in the 21st Century. Our ability to build our
Dr. Jennifer Blain-Christen, Assoc. Professor, SECEE
entrepreneurial capacity and engage in new global partnerships is better than ever.
Dr. Michael Bohl, Barrow Neurological Institute
SBHSE Advising Staff
Dr. Mitesh Borad, Mayo Clinic
A testament to SBHSE’s entrepreneurial capacity building is the fury of recent Laura Hawes, Academic Success Specialist
Dr. David Brafman, Asst. Professor, SBHSE
successes of our biomedical engineering senior capstone design teams taking Jessica Meeker, Academic Success Specialist, Sr.
Mr. Tedd Brandon, Faculty Assoc., SBHSE
top honors in local (ASU New Venture Challenge), regional (BioAccel Solutions Keli Palmer Greenhagen, Assistant Director, Academic Services
Dr. Christopher Buneo, Assoc. Professor, SBHSE
Challenge) and national (NIH DEBUT) design competitions, among others. Elizabeth Tripodi, Academic Success Specialist
Dr. Michael Caplan, Assoc. Professor, SBHSE
Likewise, SBHSE is very pleased to welcome our newest global partner, Kwame Robbie Runk, Academic Success Specialist
Dr. Jerry Coursen, Lecturer, SBHSE
Nkrumah University of Science and Technology (KNUST), in Kumasi, Ghana and five Kellie Speer, Student Services Coordinator Associate
Dr. Mo Ebrahimkhani, Asst. Professor, SBHSE
of their senior engineering students who joined this year’s biomedical engineering Vincent Pizziconi, PhD Dr. David Frakes, Assoc. Professor, SBHSE
capstone design class. Please come join us, in celebrating the success of this year’s Founder & Director Dr. Emma Frow, Asst. Professor, SBHSE
SBHSE students who have embarked upon this exciting and rewarding journey! SBHSE Design Studio SBHSE Staff
Dr. Antonio Garcia, Professor, SBHSE
Dr. Matthew Green, Asst. Professor, SEMTE Tammera Cameron, Business Operations Specialist, Sr.
Dr. Bradley Greger, Assoc. Professor, SBHSE Mark DiStasi, Associate Director of Development
Dr. Karmella Haynes, Asst. Professor, SBHSE Debbi Howard, Business Relations Coordinator
Dr. Steve Helms Tillery, Assoc. Professor, SBHSE Jessica Jensen, Business Operations Specialist
Biomedical Engineering Capstone Design & Masters Applied Project Instructors
Dr. Claire Honeycutt, Asst. Professor, SBHSE Jayson Johnson, Research Advancement Admin
Dr. Tony Hu, Assoc. Professor, SBHSE Sean Jones, Research Advancement Admin Manager
James Abbas, Associate Professor Jeffrey Kleim, Associate Professor Dr. Samira Kiani, Asst. Professor, SBHSE Alana La Belle, Laboratory Manager
Bradley Greger, Associate Professor Vincent Pizziconi, Associate Professor Dr. Jeff Kleim, Assoc. Professor, SBHSE
Sarah Matheus, Research Advancement Administrator
Dr. Stephanie Klocke, CR Bard, Inc
Elaine Miller, Executive Administrative Support Specialist
Dr. Vikram Kodibagkar, Assoc. Professor, SBHSE
Solo Pyon, Systems Support Analyst
Biomedical Engineering Faculty Advisory Design Group Dr. Tesfay Kubrom, T&T Fabrication
Michael Sobrado, Lab Coordinator, Sr.
Dr. Jeffrey La Belle, Asst. Professor, SBHSE
Dr Andrew Little, Barrow Neurological Institute Tomi St John, Business Operations Manager
Jerry Coursen, Lecturer Jeffrey Kleim, Associate Professor
Jeffrey La Belle, Assistant Professor Dr. Thurmon Lockhart, Professor, SBHSE
Michael Caplan, Associate Professor
Vincent Pizziconi, Associate Professor Dr. Steve Massia, Assoc. Professor, SBHSE
Emma Frow, Assistant Professor
Barbara Smith, Assistant Professor Dr. Michael Mooney, Barrow Neurological Institute
Antonio Garcia, Professor
Michael VanAuker, Lecturer Dr. Jit Muthuswamy, Assoc. Professor, SBHSE
Karmella Haynes, Assistant Professor
Dr. Mehdi Nikkhah, Asst. Professor, SBHSE
Dr. Vincent Pizziconi, Assoc. Professor, SBHSE
Dr. Christopher Plaisier, Asst. Professor, SBHSE
Ms. Casey Rockwood, CR Bard, Inc
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BME Capstone Projects heat when placed on target areas. NormaTherm will have five reusable heating pads, each less than 4cm thick, and can be setup
in less than a minute. It will have a lower profile than current devices, allowing for easier access to the site of the surgery. The
primary customers for the NormaTherm are medical professionals. It is designed to be used in spinal surgeries, but future plans
may include diversification into other procedures. The neurosurgery market, NormaTherm’s primary market segment, was valued at
$8.7 billion nationally and $13 billion globally in 2016. This includes the use of surgical instruments in millions of spinal surgeries.
1: Viragel: An Adenovirus Delivery System for Treating Hepatocellular Carcinoma
Michael Nguyen, Aaron Raber, Gurpaul Sidhu
4: Sleep Switch The Original Circadian Metronome™
Mentors: Dr. Mitesh Borad - Mayo Clinic | Dr. Brent Vernon - SBHSE
Alina Kilic, Taylor Little, Aleksandra Radchenko
Hepatocellular Carcinoma, or liver cancer, has several technological barriers that prevent many treatments from being effective. The
tumor environment has an especially acidic environment, which results in many chemotherapy drugs not being able to exist at the Mentor: Dr. William Tyler - SBHSE
tumor site. This, when coupled with the liver’s natural ability to break down drugs and the ability for tumors to develop resistances
to chemotherapy results in such treatments being ineffective. Additionally, radiation therapy is seldom used due to the liver tissue’s Imagine being able to go to sleep with the touch of a button on your smartphone. SleepSwitch intends to do just that to aid
intolerance to radiation damage. For this reason, genetically modified viruses are being researched as a method for treating liver tumors. the 60 million Americans who suffer from chronic sleeplessness. [NW1] The current means to treat chronic sleeplessness are
Such treatments have the advantage of being able to specifically target the tumor cells, as well as being self replicating, resulting in usually pharmaceutical, however these treatment options can cause drug dependencies as well as a buildup of tolerance. Other
only a relatively low dose being required. However, certain factors prevent this treatment from being effective as well. For one, due forms of treatments try to use a more therapeutic approach through the alteration of cognition and behaviors, however most
to the viral nature of the treatment, the immune system will be activated, resulting in the destruction of the viruses. Furthermore, the find the course of treatment taking too long to get the results they desire causing customers to stray away from this treatment
virus must be localized at the site to ensure that the treatment is as effctive as possible. Current methods of virus delivery do not option. The concept that our team has developed is the essence of engineering innovation; set to produce groundbreaking
allow for either of these main factors, as the primary delivery method involves the injection of the viruses in saline near the site. For results with those who struggle with maintaining the sleep-wake cycle. [NW2] The SleepSwitch works through the stimulation
this reason, a polymer based delivery vehicle is being developed to address these problems. Such a method would allow for both of the suprachiasmatic nucleus (the part of the brain which regulates the circadian rhythm), acting as a sort of a metronome
shielding from the immune system, as well as provide a release mechanism that would allow for sustained release of the virus. Our for the sleep cycle. Using the SleepSwitch is as simple as shutting off a light as the device will be activated by one simple tap
main target specifications include greater than 75% of the virus payload reaching the tumor and ALT levels less than 1500 in the body. on the designated smartphone app which will be available across all major mobile platforms. The SleepSwitch will be designed
to help the user fall asleep in 10 minutes or less[NW3] , lasting at least 6 hours to leave them well rested and refreshed. While
some may seem weary at first about getting an implantation they will surely reconsider after finding how quickly the benefits of
a good night’s sleep will outweigh the recovery time of the surgery. [NW4] The main target specifications of the product are a
2: Critical Care Compact IV Pump battery that lasts longer than 7 years, as well as working neurosurgeons to help hammer down a procedure which is safe, less
than 4 hours long, and helps us with figuring out the correct current to stimulate the brain at (as it varies person to person).
Itai Kreisler, Francisco Lopez, Abraham Rosengard
Mentor: Dr. Jitendran Muthuswamy – SBHSE
5: Enhanced Laminectomy Excision Device (ELED)
IV infusion has become the standard method for drug delivery. In many cases the rate at which the infusion is given is crucial for
adequate treatment. Impoverished communities and third world countries often don’t have the resources to acquire this device. This Framarz Alam, Aron Lopez-Jimenez, Ethan Marschall, Ivanna Revel
often leads to nurses to use less reliable technologies for drug delivery, that may end up causing harm to the patient or even his
or hers death. Another important issue to the adequate use of IV pumps is that with emerging technologies, experienced nurses Mentors: Dr. Michael Bohl - Barrow Neurological Institute | Dr. Jit Muthuswamy - SBHSE
feel less confident or are less likely to use new pumps. This often results in hospitals spending money on pumps that will rarely
get used or adds to the training cost of each nurse.This is why the Maimonides Medical Management team has decided to create Laminectomy procedures can be variable depending on the surgeon operating and the need of the patient. Currently, there can
a compact, affordable alternative for the current IV infusions available in the market. Currently the team is looking at technologies be multiple surgical tools that can be used to complete a laminectomy, which increases procedure time. Additionally, depending on
that could drive the cost of IV pumps down. The main focus of the team is to provide low income communities and urgent care the surgical tool used, there can be an increased risk of durotomies, most likely due to the lack of real-time feedback. Although
facilities with an infusion pump that’s easy to use, doesn’t require a pole, and can run on little power. The main customer the team has experienced surgeons learn how to use tactile feedback, there is always an associated risk of durotomy, or spinal cord injury, as the
identified are nurses and caretakers. The secondary customer will be the patients who are treated by the pump and finally insurance tools get deeper into the spine. As one of the most common neurosurgical operations, there are about 13 million people each year
companies who will decide whether or not they will reimburse hospitals and principal care facilities for buying our device. The pump who receive laminectomies to relieve back pain. And with approximately 3,689 neurosurgeons in the US throughout 5,700 hospitals,
will need to produce a maximum of 200ml/Hr, be able to modulate the flow within .01 ml of accuracy and keep a laminar flow. there is a large need for a simplified and safer alternative of performing a laminectomy. The approachable solution will have to have
quick, efficient, and safe properties to meet all customer needs. The suggested approach is a single step lamina removal with the
option of removing multiple lamina at once. This will allow for surgeons to still be in control of the procedure, but allow for a sustainable
and efficient approach. Device features include: a sharp chisel (customizable depending on the length of the patient’s vertebra) and a
3: NormaTherm: Surgical Patient Temperature Management System stable mounting guide system. Top priorities are focused on creating a stable mechanism that provides maximal visibility and feedback
to the surgeon. To comply with these needs, the clamps will be unobtrusively mounted on neighboring spinal process to create a larger
Scott Boege, Kyle Lindley, Amanda Nguyen, Luc Tieu
surgical field. From the customer needs and product specifications, projected outcomes from ELED will yield results in terms of total
Mentors: Dr. Michael Bohl - Barrow Neurological Institute | Dr. Matthew Green - SEMTE procedure time, cycles till failure, and number of successful blade cuts on bone. These results will then determine the overall efficiency
of the device and conclude whether the mission of the device is met. Further statistical analysis will validate the results obtained
During spinal surgeries, the combination of anesthesia and the large incision area causes tremendous heat loss in the patient. from testing and will solidify ELED’s capability to deliver an efficient procedure time and reduce the risk of durotomies, significantly.
Hypothermia is a serious concern that can lead to various medical issues such as impaired wound healing and cardiac complications.
Surgeons currently use forced-air devices: an inflatable drape is placed over the patient and warm air is blown through it. Problems
include bulkiness, fragility, and patient contact with non-sterile air. NormaTherm is an incremental improvement to this device by
using a resistive heating method to deliver heat to areas of high heat transfer efficiency to the patient’s core such as the neck,
axillae, and groin. This allows for a more effective use of power without the use of non-sterile fluid convection. The device will
be comprised of the heating unit with a user interface, display screen, and attachable heating pads. Patient temperature will be
displayed with options of multiple heating levels. The warming unit will transfer energy to the heating pads and operate through
a feedback mechanism to regulate the patient’s temperature. A heating element incorporated in the heating pads will provide
6 7
6: CryoRelease: Temperature Regulating Dynamic Splint for Spasticity Relief repurchase the device. Market expansion may take place, as the ClariVision attachment can be easily adapted to fit a wide range of
endoscopes. Several design concepts have been carefully examined, these concepts include chemical and mechanical mechanisms.
Brandon Dorr, Cole Hunter, Chris Wiedeman The favored design concept is a mechanical mechanism. The attachment itself is comprised of multiple components that work
together to provide a continuously clear view inside the human body. The current design concept utilizes ultrasonic waves to disperse
Mentor: Dr. Jeffrey Kleim - SBHSE
fluids and debris while keeping the integrity of the endoscopes field of view. The device also contains a vacuum system that removes
Muscle spasticity is a chronic condition in which affected muscles are constantly activated, leaving joints immobile. Because bodily fluids without compromising the size of the device.
spasticity is a condition often resulting from neurodegenerative diseases, such as cerebral palsy, stroke, and multiple
sclerosis, over 12 million people suffer from spasticity worldwide. Over half of post stroke-patients with spasticity develop
contractures, or permanent shortening of muscles and tendons, because the condition is often left untreated. Furthermore, 9: Cervical Collar with Detachable Jaw Piece
muscle spasticity greatly inhibits the effectiveness of physical therapy for neurodegenerative diseases, and while treatments
exists, these current treatments are time-consuming, require in-person professional care, or carry adverse effects. Danielle Beach, Sara Gubrud, Lauren Tuttle
CryoRelease provides a novel approach to relieving spasticity by utilizing both cryotherapy and kinesiotherapy in a single automated Mentor: Dr. James Abbas - SBHSE
device. Through a customer need analysis involving physical therapists and patients, the team behind CryoRelease determined In emergency trauma situations, clearing and maintaining airway functionality is critical for positive patient outcomes. In patients
that patients need a device that can relieve hand spasticity at home and directly before therapy sessions. The device must also with an injury to the cervical spine, cervical collar prevent secondary injuries by immobilizing the cervical spine. However, cervical
be safe, easy to operate, and non-invasive. As a result CryoRelease is currently developing a wearable hand splint that can that collars can restrict medical personnel from performing other emergency medicine techniques. Currently, cervical collars have to be
both stretch and cool the hand to greatly reduce spasticity in under fifteen minutes of use. The efficacy of physical therapy is completely removed from the patient during intubation as the design does not allow the jaw to fully open. Removing the cervical
often tied to patient compliance outside of therapy, and the high rate of contractures shows the low compliance at the home. collar is dangerous to the patient because the cervical spine is not immobilized, which increases the probability of the patient
A simple product that can be used on a daily basis will not only decrease the rate of contractures in patients and increase the developing a secondary injury. It is our mission at SoLiD to support emergency medical professionals by improving the ease of use of
effectiveness of in-person therapy when used before sessions, but will also give these patients greater relief and independence. the current cervical collar while reducing the risk to the patient. The market size consists of 5 million trauma patients a year requiring
spinal immobilization. Currently, the concept that this team is proposing is to add a mechanism on the cervical that allows the jaw
to open for intubation without compromising the structural integrity of the device. A component of the device below the jaw will be
7: Alzheimer’s Monitoring and Alert Wearable detachable, allowing the jaw to open. This detachable component will allow for the facilitation of life saving airway treatment while
still providing immobilization of the cervical spine, as the cervical collar will not need to be taken off of the patient in order to perform
Kyle Brague, Catherine Piatak, Marissa Seelhammer, Stacy Stoddard, intubation. Main target specifications for the final product will include that the cervical collar allow less than 2 degrees of lateral and
Brittney Wong vertical rotation, and that the detachable component allows the jaw to open 2 inches.
Mentor: Dr. Jit Muthuswamy- SBHSE
Currently, there are only a few devices on the market intended to improve at-home care given to Alzheimer’s patients. Most devices 10: EsophaCool: A Thermoregulatory Device for the Monitoring and Cooling
currently marketed for Alzheimer’s patients only include GPS location or an emergency alert button pendant and are easily taken of the Esophagus during Cardiac Ablation Procedures
off or forgotten. Instead, caretakers are required to constantly supervise patients and purchase multiple medical devices to monitor
biometrics manually. More than 5 million people in the United States alone are battling Alzheimer’s disease, and the prevalence of Fahhad Ashour, Sebastian Fonseca, Bakir Mousa, Jacob Packer
Alzheimer’s is expected to rise in coming years due to the aging population. These patients suffer from loss of autonomy, dignity,
and higher risk of stroke or heart attack. Alzheimer’s and dementia patients as well as their caregivers need more freedom without Mentors: Dr. Jitendran Muthuswamy – SBHSE | Dr. Tedd Brandon - SBHSE
risking the health or safety of the patient. The BOSCK team is aiming to develop a wearable monitoring and alert system according Atrial Fibrillation (AF) is the most common type of heart arrhythmia in the Unites States, affecting at least 2.7 million people. Typified
to best practices that will target this problem. This wellness device will be sold to the caregivers of geriatric patients that are suffering by an irregular or quivering heartbeat, AF is caused by an abnormal firing of conductive tissue in the upper chambers (or atria) of the
from Alzheimer’s and will enhance the lives of both the patient and the caregiver. The device will be made to improve caretakers’ heart, thereby disrupting the normal physiological circuitry of the heart. AF alone is classified more as a low risk medical condition
peace of mind by providing them access to the health metrics and safety of the patient while providing a cost-effective solution for rather than a life threatening disease, but is of high interest to cardiologists because of its link to various dangerous diseases and
improving communication. Additionally, the device will be integrated into the everyday clothing of the patient to increase use. The conditions. For example, patients are five times more likely to experience stroke when diagnosed with AF. One minimally invasive
target specifications will ensure the final product accurately communicates the patient’s heart rate and blood oxygen levels, and procedure used to correct AF is cardiac ablation. In this procedure, catheters (thin, wire-like devices) are inserted into the body,
sends alerts of dangerous biometric abnormalities and falls detected directly to the caregiver. typically through the femoral vein. Using these catheters, the heart’s electrical signals are mapped, the problematic conducting
tissue is located, and a specialized catheter is then used to introduce either extreme heat (radiofrequency ablation) or extreme cold
(cryo-ablation) to the affected area. This ablation catheter typically creates scar tissue, disrupting the abnormal circuitry occurring
8: ClariVision: Endoscopic Lens Self-Cleaning System in AF. A problem that arises in these surgeries is the increased risk of formation of fistulas, or abnormal passages, between the
left atrium and esophagus, which when developed, results in death in nearly 70% of cases. These fistulas form due to necrosis
Patrick Conely, Reaghan Fletcher, Isaiah Gonzales, Alexandra Torres (cell death) brought about by increased heat (or freezing, in the case of cryo-ablation) of the area from ablation. The EsophaCool
Mentors: Andrew Little - Barrow Neurological Institute Thermoregulatory system aims to accurately measure the temperature of the external esophageal wall during ablation and regulate
temperature spikes caused by ablation. This thermoregulatory device would employ a controlled endothermic reaction to bring the
Michael Mooney - Barrow Neurological Institute temperature of the esophagus down to appropriate physiological levels.
Jit Muthuswamy - SBHSE
Current nasal endoscopes do not embody a self-cleaning system for the lens as debris and bodily fluids obstructs the user’s
visualization. Typically, manual cleaning of the lens is the only effective method to improve visualization. The manual cleaning method 11: Stethosound: A Combination Ultrasound Stethoscope Device
is very time consuming and frustrating for users as it requires them to retract the endoscope in order to clean the lens. Other Spencer Cobb, Justin Mieth, Zachary Ticktin
common mechanisms used to clean endoscopic lenses are irrigation systems, but users indicate that as these systems are effective
they do not keep the lens continuously free from debris. ClariVision has been developed to improve visualization as well as decrease Mentor: Dr. William Tyler - SBHSE
overall operating time. Primary customers for this device are neurosurgeons, otolaryngologists, and ophthalmologist as they typically
perform nasal endoscopic surgeries in the operating room. There are 38,000 practicing surgeons and specialists that use nasal Traditionally, the stethoscope is the main tool used during a patient’s physical exam due to its cost-effectiveness and simplicity
endoscopes within the United States. ClariVision is an attachment for existing endoscopes therefore hospitals do not have to of design, allowing for vital organs to be monitored with ease. However, the stethoscope is not enough when a patient presents
8 9
a potentially threatening condition, causing further diagnostics to be required. The ultrasound global market is expected to reach 14: The Nitpick: A Micro-Machined Apparatus for the Treatment of Pediculosis
$6.86 billion by 2021 at an annual growth rate of 5.9%. However, the market is stepping away from traditional ultrasound machines.
Currently, the market seeks cost-effective, reliable point of care ultrasound devices that are also easy to use and implement in Michael Catchings, Kaylena Conklin, Robert Culibrk, Andre Nguyen
a clinical setting to reduce wait times. The Stethosound addresses the market needs by providing a familiar and easy to use Mentor: Dr. Bruno Azeredo - Polytechnic Campus
device that incorporates the simplistic nature of the stethoscope with the enhanced imaging diagnostic capabilities of point-of-care
ultrasound. The device can quickly transition from auscultation during a physical exam to imaging the cardiovascular and pulmonary According to the CDC, an estimated 6 -12 million people in the United States have lice each year, and over $400 million are spent
systems using B-mode and Doppler imaging. This allows the doctors to Primary customers of the device include primary health annually on over the counter treatments. However, these treatments are becoming less effective because of the evolution of “super
care providers, clinicians, and EMTs. The submarkets that this device addresses are medical schools and educational settings for lice,” which are more resistant to these treatments. The current effective treatment methods are expensive, but have unfortunate side
student and instructor use. Further market expansion includes use within urgent care facilities and third world countries where effects such as varying levels of dermal irritation and potential carcinogenic effects. New treatment methods on the market are often
traditional ultrasound devices are not commonly found or used. The mission of the Stethosound is to provide a device that can not covered by insurance, and are unavailable for low income families. The Nitpick offers an effective, single-step treatment method
seamlessly transition between acoustic signal capturing and point of care ultrasonic imaging for fast and accurate diagnosis of that takes less than 6 hours from start to finish to use. The device consists of 40-60 tines, spaced less than 400um apart with micro-
various conditions while maintaining a low cost of use. abrasive regions between the teeth to better treat pediculosis at the microscale level without damaging hair or with any adverse
side effects. Primary customers would be parents of children with pediculosis, while secondary customers include school nurses,
pediatricians, and rural clinicians. Market expansion may include clinics in developing countries. As pediculosis affects predominantly
12: Ventriculoperitoneal Shunt Distal Catheter Retainment Device children 3-11 years of age, and has a high degree of returning after treatment, The Nitpick provides an innovative, intuitive, single-
step rapid treatment method for lice that reduces hand fatigue when compared to other similar devices on the present market. Hand
Mohammad Alhusayni, Ryan Giudice, Karthik Nambiar, Gareth Palas held, comfortable, and reusable, The Nitpick caters to the needs of busy parents by treating lice faster.
Mentors: Dr. James Abbas - SBHSE | Dr. Jennifer Blain-Christen - SECEE |
Dr. Michael Bohl - Barrow Neurological Institute
15: Wearable Blood Pressure Sensor Employed to Detect Preeclampsia
A recurring issue which develops from the implantation of ventriculoperitoneal shunts is the distal catheter tubing that delivers Lexi Bounds, Megan McGuire, An Tran
cerebrospinal fluid to the abdominal cavity backs out of the peritoneal incision. This leads to the neurosurgeon having to carry
out a revision surgery in order to place the distal catheter tubing into the abdominal cavity to prevent further issues which may be Mentor: Dr. William Tyler – SBHSE
caused by cerebrospinal fluid penetrating other parts of the patient’s body. A potential solution to this problem is the attachment
of a device to the catheter tubing that ensures it does not back out of the abdominal cavity while being designed to not further Preeclampsia (PE) is the third leading cause of maternal death worldwide and accounts for 5-8% of pregnancy-complications in
inhibit the patient’s ability to move freely without risk of shunt dislodgement. That solution is what the design team is in the process the United States. PE is characterized by elevated blood pressure, abnormal kidney tests, low platelet count, liver abnormalities, and
of developing. The primary customer for this type of device would be neurosurgeons that perform hydrocephalus shunt placement pulmonary edema. If left untreated, the condition can progress to Hemolysis Elevated Liver Enzymes Low Platelets Counts (HELLP)
surgeries, as well as hospitals and other care facilities that perform ventriculoperitoneal shunt placement surgeries. Adult patients syndrome and can lead to the onset of eclampsia, or convulsions during labor. The exact mechanisms underlying the pathology
with hydrocephalus and receive the retainment device are also customers for the design team’s device. Another important customer remain unknown, with delivery of the child and placenta the only available treatment method. Thus, it is critical to develop an accurate
in the market of the device are shunt manufacturer’s that may consider including the retainment device with future sales of their and reliable diagnostic tool to detect preeclampsia before the condition progresses in severity. The goal of this biomedical device is
current shunt technology. The market segment for the device is centered around adults with hydrocephalus that received VP shunts. to provide an early detection method essential to improving prenatal health outcomes for pregnant women while supplying clinical
Around 700,000 adults in the United States have normal pressure hydrocephalus and if the device were adapted to be used in professionals additional tools in maternal care. We aim to develop a wearable blood pressure monitoring device, supplemented with a
pediatric hydrocephalus, this market would increase exponentially. The concept the design team is creating would deploy upon smart phone application, capable of (i) recording prenatal metrics at specified time intervals, (ii) transmitting the measurements to the
entering the patient’s abdominal cavity and retract at the discretion of the neurosurgeon. This allows for unobstructed and efficient user’s smart phone or tablet, and (iii) exporting patient medical files to clinical personnel. Specifically, the device will measure blood
placement of the retainment device that would not inhibit shunt performance. The primary target specifications for the final product pressure and heart rate using LEDs to obtain ECG and photoplethysmogram signals. Future work includes developing algorithms
will include use in abdominal cavity pressures between 50-80 mm Hg and a Young’s Modulus tolerance of 20-25 kPa. for signal processing, validating the accuracy and sensitivity of the measurement method, and generating prototypes of the device.
13: Breast Microcalcification Biosensor 16: Optimization of a HDACi-Loaded PLA-PEG Nanoparticle for the Treatment of TBI
Adam Grula, Shreya Ramkumar, Marvin Vergara, Robert Wen Peter Hillebrand, Ethan Mathew, Gergey Mousa
Mentor: Dr. Michael Caplan - SBHSE | Ranjani Kumaran, CR Bard, Inc | Mentors: Dr. Sarah Stabenfeldt - SBHSE | Dr. Rachael Sirianni - Barrow Neurological Institute
Tyson Anderson, CR Bard, Inc Over 3 million people per year in the U.S. suffer from traumatic brain injuries (TBIs). Additionally, TBI plays a role in roughly 30% of
all injury deaths annually. Current treatments alleviate secondary physiological symptoms from TBI and do not address underlying
Microcalcifications are small deposits of calcium oxalate or hydroxyapatite that exist in differing patterns within breast tissue. These
pathological mediators of neuropathology. One approach to combatting this is through epigenetic modifications that have the
deposits can act as an early indicator for breast cancer. About one of eight women in the United States will develop invasive breast
potential to aid in neurological recovery. Our team aims to evaluate and optimize a quisinostat-loaded, histone deacetylase inhibiting
cancer during her lifetime. Adding to that, approximately 230,000 out of 290,000 new cases of breast cancer diagnosed each
(HDACi) nanoparticle to treat TBI. The primary customers for this device will be hospitals and neurotrauma experts. The market
year end up as invasive. The current method used for microcalcification detection involves a mammogram of the breast followed by
segment for this product would be sizable considering TBI patients currently have minimal treatment options available and the
confirmation through a stereotactic biopsy and pathological analysis. The typical stereotactic biopsy procedure involves using low-
market size will be substantial since there are over 3 million TBI patients per year in the U.S. alone. The current concept task is
dose X-ray images to locate the regions and take multiple biopsy samples for confirmation. In this procedure, the patient lies in a face
to optimize existing HDACi-loaded nanoparticles for TBI using a small animal pre-clinical model; this nanoparticle system was
down prone position with the breast compressed through a hole in a table. Typical procedures last between 30 and 45 minutes, while
previously developed by Dr. Rachael Sirianni for glioblastoma applications. The nanoparticle will be injected systemically, cross the
the patient lies in this uncomfortable position. Microcalcifications are not easily seen with ultrasound imaging, often considered the
transient break in the blood-brain barrier, and passively accumulate within the injury penumbra of a contused brain. The efficacy
gold standard for breast biopsy imaging. An alternative solution to this problem is to develop a bioimpedance sensor for the detection
of the nanoparticle at various concentrations will be evaluated by measuring HDAC activity at the injury site post-administration
of microcalcifications that can place patients in a more comfortable position during a biopsy procedure. Impedance measurement
using immunohistochemistry. The dosages of the nanoparticles tested will be informed by a mathematical model simulating the
studies have been performed, but not in a clinical setting due to a low sensitivity and specificity. We are hoping to overcome this
endogenous neural environment. Further, the efficacy will be evaluated through a biodistribution/pharmacokinetic assay involving
challenge with the development of a highly accurate impedance probe that can be used to improve the biopsy experience for the
mass spectroscopy of various tissues at a range of time points post-administration. The primary target specifications for the final
patient and physician. The customers for this product include interventional radiologists as well as patients with microcalcifications
product will be a 30% increase in histone acetylation in the brain as compared to a control at 24 hours post-administration and a
in their breast tissue. Our future work will include prototype improvement and verification/validation testing.
90% decrease in the systemic concentration of the nanoparticles between the 1 hour and 5 day time points post-administration.
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17: I-CON: Ocular Tracking Device for Traumatic Brain Injury design include an app update time of 10 minutes or less and a battery life of at least 20 hours. Our device can be incorporated into
any orthopedic brace, therefore our market segment will be global orthopedic braces and supports; which has been valued at $3.76
Michael Bejarano, Sara Belko, Christina Monteilh, David Shumate billion as of 2017. With the key customers within the segment being brace fabricators and prescribing orthopedic physicians. This
Mentors: Dr. Jennifer Blain-Christen – SECEE | Dr. Sydney Schaefer - SBHSE product supports the quality based outcome models insurance companies and hospitals have adopted; therefore, they would also
benefit from this design.
Currently, traumatic brain injury (TBI) is the leading cause of death and disability worldwide with approximately 1.7 million people
sustaining a TBI annually. As the United States spends 48.3 million dollars per year on hospitalization and deaths related to TBI,
the need for a consistent and effective measure for TBI is apparent. Current techniques to diagnose TBI and concussions includes
20: User-Centric, Modular-Component Dog Prosthesis
the Sport Concussion Assessment Tool (SCAT), the Bess balance assessment, the ImPACT assessment, and the King Devick
test. The current standards encompass many areas of interest for diagnosing TBI including neurocognitive, eye, balance, and Bjorn Houman, Jacob Irwin, Rachel Ponstein
memory. However, problems with the current techniques include lengthy examination time, expensive operations, and subjective
interpretations by primary health care providers. TBI diagnosis is also primarily dependent on the patient’s verbal feedback, which Mentor: Dr. Sydney Schaefer - SBHSE
can be subjective. Current standard clinical eye tests include horizontal and vertical saccades, horizontal and vertical vestibulo-
ocular reflex, convergence, reverse convergence, pupil dilation, smooth pursuit, and gaze holding. The I-CON solution will create Veterinary medicine has been making the change from surgery-centric treatment to the more common use of pet prosthesis, and
a standardized way to track the eyes to assist in diagnosing TBI by automating the standard eye tests and interpreting the results with that there has been a shift from full-limb amputation to amputation with prosthetic candidacy in mind. The use of a prosthetic
quantitatively. The I-CON solution is an ocular encapsulated recording device that will incorporate an LED system to simulate the allows animals to treat injuries or maintain a standard quality of life without the use of invasive surgical procedures. Unfortunately,
current clinical eye tests and two cameras, one for each eye, to track movement and pupil dilation. All video images will be sent there are very few dedicated pet prosthetists in the US and the process of custom prosthetic fabrication often excludes face-to-face
via Bluetooth to an iOS application where image processing will proceed to compare the velocities and magnitudes between pupil interactions leading to device discrepancy. The goal of the MediPaw Pet Prosthetic is to create a user-centric design that allows for
dilations to a baseline reading. Main target specifications for the product will include accuracy on recording eye movement, run time
the replacement of the modular components to accommodate the dog’s needs. To achieve this, gait analysis is being performed to
of fifteen seconds per test, and a battery life of four hours. This device will be advertised to the market segments of athletics and
emergency departments with the customer being primary care providers and healthcare professionals. determine the relationship between the foot shape and the elbow angle per gait cycle for dogs with and without prosthetics. This
analysis will be used to compare the natural gait cycle of an uninjured dog to that of a dog using the MediPaw Pet Prosthetic with
the intention to create a natural gait cycle. This data analysis and the utilization of mathematical models will allow the creation of a
18: Outpatient Wearable Technologies: A Wearable Optical Sensor for Non-Invasive device that the animal can comfortably wear, and the owners can easily modulate to fit the animal’s needs. The expected results will
Respiration Rate Monitoring show that the design of the prosthetic will allow for easy modulation intended for the treatment of animals with varied amputation
sites. This design will allow owners to replace heavily worn parts with new ones, without the inconvenience of shipping the prosthetic
Bryce Gonzales, Mohammed Almaimani, Zach Fisher back to a busy prosthetist (forcing the animal to go without during this time). This user-centric, modular-component dog prosthetic
will ensure that the animal has natural gait and is comfortable and safe when wearing the prosthetic for extended periods of time
Mentor: Dr. Jeffrey La Belle - SBHSE
while performing standard tasks.
Outpatient Wearable Technologies is introducing a new wearable device for users to accurately monitor their respiration rate from at
home. Patients suffering with COPD, congestive heart failure, and pneumonia account for the highest rate of hospital readmissions
within thirty days. Health organization’s quality in the United States are measured by the rate of readmission. A health organization 21: SpineAlign: Scoliosis Intraoperative Load Sensor
with a lower readmission rate will be rated higher on a quality scale, whereas a health organization with a higher readmission rate will
be rated lower on a quality scale. We are focusing on readmission within the first thirty days after the patient is discharged from these Priscilla Hernandez, Jinglin Liu, Amanda Smith, Megan Wieser
health organizations. We plan on selling these devices to health organizations to distribute to patients for home monitoring purposes. Mentor: Dr. Jeffrey LaBelle - SBHSE
Our market size includes about 3.3 million patients. The multiaxial continuous respiration rate monitor utilizes a computer mouse
optical sensor that tracks and records the movement of lungs. Through this, the device is able to monitor breathing rate and volume. Current methods and technologies in adolescent idiopathic scoliosis surgeries, or AIS surgeries, do not provide accurate, validated
The intended purpose of our device is to assist health organizations to reduce readmission rates by maintaining constant monitoring measurements of spine parameters. One approach that can be used to solve this problem is creating an intraoperative instrument that
of the patient after discharge. The multiaxial optical continuous respiration rate monitor is a basic optical sensor based device that can measure the load distribution in the thoracolumbar section of the spine, the most common location for abnormal curvature. Our
tracks the movement of lungs. The sensor is programmed to translate the lung’s movement into respiratory rate. By keeping constant team’s objective is to create an intraoperative sensor that can translate contact forces into a load display. This will provide surgeons
attention on respiration rate, health organizations can identify possible issues with a patient outside of the hospital before their issue and researchers with a quantitative way to measure the load instead of having the surgeons rely entirely on visual inspection and
becomes critical. In conclusion, continuous monitoring to respiration rate will aid health organizations and discharged patients to intuition. The primary customer for our device are AIS surgeons since they will be the people that use the device. The market
keep track of their health and be identified of health events before it is too late. segment for this device would be the surgical instruments segment, which is a large segment for medical devices due to the need
of making procedures easier for doctors. There are about 29,000 AIS surgeries performed per year, each costing approximately
$92,000. The main specification of our product is to numerically measure load in the thoracolumbar region with 5% error, which will
19: Integrated Bioinformatics for Orthopedic Braces potentially reduce the number of follow-up surgeries.
Riley Baranek, Andrew Carlson, Jordan Shinn
Mentors: Dr. Michael Bohl - Barrow Neurological Institute | 22: BRiCS: Cell Isolation and Addressing System
Dr. Michael VanAuker - SBHSE | Ron Whiteside - Hanger Calvin Baumgartner, Srekar Nagishetty, Rob Schultz, Brianna Steele
Millions of people use orthopedic braces each year, yet compliance is exceptionally low. This lack of compliance makes it difficult Mentor: Dr. Christopher Plaisier – SBHSE
for physicians to determine if their treatment plan is working. When patients do not comply to their treatment plan, their recovery Wider application of single-cell (SC) analysis has been limited by the lack of an easy-to-use and low-cost strategy for SC isolation
takes longer and is less effective. One reason for low compliance is that patients are overestimating how long they are wearing their that can be directly coupled to SC sequencing and SC cultivation. Current SC RNA preparation technologies are expensive to
brace by up to 150%. In addition, while some patients may be using their brace, they are not always wearing them in the correct use because of highly-priced, one-time-use reagents. Highly-integrated systems present a high cost-barrier to entry for new labs
manner. Our teams goal is to instill digital vigilance by creating a bioinformatics/compliance monitoring system comprised of various looking to incorporate the technology. A convenient and flexible platform which can isolate single cells with high efficiency and is
temperature and pressure sensors, as well as a display. This device will track how often the patients are wearing their brace, and if compatible with conventional protocols and instrumentation for downstream analyses (i.e. quantitative PCR or genomic sequencing
they are wearing it correctly. The compliance data will be displayed on a screen for the patients viewing, and be sent in real time to on sc level) is highly desired. The conceptualized device hopes to tackle the high-cost barrier to entry by developing a flexible low-
the patient’s physician via an app. Improving comfort is another avenue to aid in increased compliance. Thus, the design is modular cost system, considerably speeding up and simplifying the task of isolating SCs. The market segments for this product are genomic
and will allow for outputs to fans in order to reduce the heat felt by these braces. Important product specifications for our final research and cell/tissue research, which is a growing industry due to increased demand for targeted personalized medicine. BRiCS
12 13
will be marketed to an overall customer base of 3 million researchers working on cell and tissue research in the world. The device through the mouth with an endoscope and extraction devices. These devices often cause shredding of food material, require multiple
will also add value to data acquired from its use by eliminating ambiguous and confusing data points, known as collisions. The passes down the scope, and increase overall procedure time. This increases the risk of pulmonary aspiration (material falling into the
technical specifications of the device will involve a pneumatic binary addressing system which will individually address cells through lungs), compromised airway, and perforation of the esophagus. The estimated annual rate of occurrence of esophageal food bolus
a microcomputer. This addressing system will create a spatial control of the cells to be delivered to specified wells of a microtiter impactions is 13 cases per 100,000 people (GIE, 2016). Common causes of food obstructions include eosinophilic esophagitis,
plate. BRiCS will further tackle the issue of ambiguous data points during sequencing by eliminating cell doublets (cell-cell adherent strictures of the esophagus, and diffused motor abnormalities of the esophagus. Our product development team, JECK Medical,
complexes) through acoustophoretic cell filtering. Main target specifications for this device will involve a sample throughput (flow is developing the EndoViper upper gastrointestinal foreign body extraction device. EndoViper provides an innovative solution to
rate) of 5mL/hr through the system and will maintain an internal flow pressure under 0.25 Pa (to prevent cell lysis). esophageal food bolus impactions using industry best practices and quality systems. The device is a one-time use, disposable,
three-pronged 24 mm diameter grasper featuring a security net, lasso-closing mechanism, 200 cm long catheter, and control handle.
EndoViper is being developed with product specifications that are responsive to the needs of gastrointestinal healthcare staff and
23: Adjustable Percutaneous Transluminal Angioplasty Balloon Catheter their patients. The device will provide a safer and more efficient method for food bolus extraction, providing procedure time savings,
and faster procedure room turnover. EndoViper will also reduce average labor costs, duration of anesthesia, and decrease the risk of
Priscilla Delgado, Peter Haist, Alex Kirk, Devon Rusk, Ian Sanders complications. Our team will continue development this spring with a working prototype of the EndoViper.
Mentors: Dr. Michael Caplan - SBHSE | Edgar Sanchez Garcia – CR Bard, Inc |
Stephanie Klocke – CR Bard, Inc | Casey Rockwood – CR Bard, Inc | Brandon Simmons - CR Bard, Inc
26: Mechanical Transtibial Prosthetic Device
Balloon catheters have a wide range of applications for various different heart diseases and conditions to open up multiple different
Lauren Britton, Sarah Fakhoury, Ladan Kamali Sarvestani, Christina Salas
vessels that have experienced some sort of obstruction or constriction to blood flow. Because of the balloon catheter’s diversity,
there are currently various different codes for balloon catheters with varying lengths of the sheath and lengths and diameters for Mentor: Dr. Thurmon Lockhart - SBHSE
the balloon itself. A major problem from this stems from the user having to have various balloon catheters always in stock to be
able to have any scenario that the user might need covered, or the consumer not having the right size to perfectly fit the vessel. Our Transtibial amputees commonly experience joint pain and muscle fatigue caused by overcompensating with their remaining limb
team aims to cut down on the stock that the consumer would have to keep by creating an adjustable balloon catheter. The primary in order to stay comfortable while using their prosthetic device. There are many micro-controlled motorized prosthetic devices
consumer for this device will be cardiologists who regularly perform balloon angioplasty procedures at various different hospitals, currently on the market, however, these devices are very expensive and require high maintenance over time. Current motorized
clinics and private practices. The market segment for this product is very large with it encompassing many patients who have some devices are also known to be too heavy and have a slow reaction time during gait. Globally, the prosthetic market is worth $1.62
sort of heart condition, as constriction of blood flow is a side effect. The market consists of roughly 4.6 million cases each year with billion, and is expected to grow to $2.63 billion by the year 2026. Below knee amputations (BKA) are the most common type and
some sort of atherosclerosis, and the market is projected to grow to $3.4 billion by 2022. The main target specifications that the account for about 50% of amputations, with 2 million transtibial amputees alone in the United States. This number is expected to
final product will include is a burst pressure for the balloon of up to 40 ATM, and a length for the shaft that can go from 50-200 cm. increase by roughly 185,000 annually and Pro-Step aims to contain 3% of the total market segment. The Pro-Step team is currently
developing a transtibial prosthetic device capable of providing postural stability using a cost effective mechanical device rather than
an expensive micro-controlled device. The product under development uses a carbon fiber body in conjunction with mechanical
joints in order to mimic natural gait movement, while providing structural stability. The prosthetic device will remain lightweight, with
24: Hydra Cell: Engineered Electroreceptive Cell for Brain Computer Interfacing
a target maximum product weight of 1.5 kilograms, and will be able to support users weighing up to 200 pounds. Lastly, the device
Jeremy Ellis, Joshua Hislop, Morgan Johnson, Abigail Rene aims to provide 90% efficiency for energy absorbance and return to help reduce the user’s fatigue and musculoskeletal strain during
normal everyday activities. Pro-Step hopes to help transtibial amputees feel comfortable and confident, and overall, return a sense
Mentor: Dr. Mo Ebrahimkhani - SBHSE of independence to them.
Improving interface between the nervous system of the human body and the electronic devices of modern medicine is an emerging
goal of professionals and manufacturers in the field of neuroengineering. The progress of this field is hindered by flaws that
are common to most, if not all, brain-computer interface devices on the market today. These problems include high noise, high 27: Stroke Induced Hemiparesis Rehabilitation Device
dimensionality of data collected and the restriction of many major neuron-interaction devices, such as patch clamps, to in vitro
Polette Avila, Lemlem Brook, Christopher Saar
functionality only. The neurological medical device manufacturers and entertainment device developers both have significant
demand for the next generation of brain-computer interface; the market size for these devices is expected to reach $1.23 billion by Mentors: Dr. Jeff Kleim – SBHSE | Jitendran Muthuswamy - SBHSE
the year 2024. The Hydra Cell is a neuron that has been engineered to produce a pair of membrane proteins traditionally found in
marine animals such a sharks and rays. These proteins will make these neurons both receptive to and able to produce electric fields. Currently, there are no cost-effective links between clinical rehabilitation for ischemic stroke hemiparesis and home rehabilitation.
These cells, in combination with a field generation device to communicate with them, will allow electronic devices to interact directly Patients that suffer motor function disorders due to a stroke event require immediate rehabilitation therapy to take full advantage
with the nervous system. These communications will be done with localized electric fields with energies on the order of 1 mV/cm of regaining some functionality of their impaired extremity. The process of repair is known as neuroplasticity, it is our brain’s natural
in order to facilitate communication. HydraCell will allow the sending and receiving of signals to and from the body on a cell-to-cell ability to conform to change and is fundamental in stroke recovery. In order to increase neuroplasticity, research has shown that
basis, improving resolution and reducing noise associated with traditional interface electrodes. Additionally, these engineered cells patients need to have an increase in rehabilitation programing for repetition and quality movement. Spending on stroke rehabilitation
will be useful beyond the lab setting. An individual’s native neurons can be non-permanently modified to carry the genes necessary has been estimated at around $12,000 per patient annually, the U.S. spends approximately $34 billion per year on a population that
to function in an electroreceptive capacity, resulting in a device that is highly biocompatible as well as functional. has around 710,000 strokes per year. Our market segment would primarily be patients that are 65 and older who have had a stroke
that affected their upper extremity, however there is additional expansion into traumatic brain injury, Multiple Sclerosis, and Cerebral
Palsy. Currently, stroke rehab devices fall into two categories; one group is assistive in nature using rubber bands, springs or direct
electrical current to assist movement. These types bypass the brain’s role in movement and do not help increase recovery through
25: EndoViper: Upper Gastrointestinal Foreign Body Extractor
neuroplasticity. The second group of devices are more precision based, using desk mounted systems or large supporting devices
Justin Blommer, Erik Drager, Christopher Pina, Krystal Schmitt with computer software to induce quality repetition. These devices are a stand-alone system that are expensive, non-portable, and
are divorced from occupational therapy practice as a continuum of overall care. Our device will employ a wearable design that can
Mentors: Dr. Barbara Smith – SBHSE | Dr. Sylvain Sidi – Banner Desert Medical Center | be used to measure, count quality movement of the hand/wrist, provide feedback to the patient in their home using inputs set by the
occupational therapist, and record data that can be displayed to show the patient’s rehab progression over time.
Dr. Aijaz Sofi – Arizona Center for Digestive Health
Current limitations of gastrointestinal foreign body extraction devices cause the removal of esophageal food impactions to take
30-90 minutes and involve upwards of 9 devices. Gastroenterologists must remove food bolus impactions from the esophagus
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