Prefeasibility Report Expansion of API & Intermediates chemicals manufacturing unit of M/s. Unichem Laboratories Ltd - Environmental Clearance
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Prefeasibility Report
Expansion of API & Intermediates chemicals
manufacturing unit of
M/s. Unichem Laboratories Ltd.
Plot no. 99, MIDC Dhatav, Roha, district Raigad, Maharashtra. PIN-402116
Prepared by,
Sadekar Enviro Engineers Pvt. Ltd.
QCI-NABET Accredited EIA Consultancy for Schedule 5(f), Category-A
MoEF Recognized and NABL Accredited Laboratory
Plot no. A-95, Wagle Industrial area, Rd. no. 16, Kisan Nagar rd. Thane,
Maharashtra. PIN-400604
October 2018
Table of Content Sr. Title Page no. 1. Executive summary 1 2. Introduction of the project 7 3. Project Description 12 4. Site Analysis 20 5. Planning 21 6. Proposed infrastructure 22 7. Rehabilitation and resettlement 23 8. Project schedule and cost estimation 23 9. Analysis of proposal 24
M/s. Unichem Laboratories Ltd.
1. Executive Summary
Sr. Component Status
No
1 Name of Project Expansion of API & intermediates manufacturing unit of M/s
Unichem Laboratories Limited
2 Location Plot No. 99 MIDC Dhatav, Roha Dist: Raigad
Maharashtra, India. PIN: 402116
3 Product Type APIs and Intermediate chemicals
4 Project Type Expansion (Brown Field Project)
5 Schedule as per EIA 5(f)
Notification, 2006
6 Category of Project ‘A’
(General condition is applicable- project site is within 5 km of
notified eco-sensitive area)
7 Area Details (in Sq. m.)
Existing Proposed Total
i. Total Plot Area 48885.00 -- 48885.00
ii. Built-up Area 24496.46 2691.65 27188.11
iii. Parking area 650 150 800
iv. Greenbelt Area 6790 967.46 7757.46
8 Production Capacity (MT/Y)
Existing Proposed Total
Products 377.77 122.23 500
(API and
Intermediate
chemicals)
By-product -- 660 660
(Spent solvents)
9 Budgetary Allocation (INR in lakhs)
i. Project Cost 1000
(Expansion)
ii. Capital EMP Cost 670
iii. Recurring EMP cost 65
(per annum)
10 Existing Proposed Total
Man power (Nos.) 550 50 600
11 Power Requirement
Existing Proposed Total
i. Connected Load (KW) 3966 1250 5216
ii Power demand KVA 2550 1000 3550
12 Fuel Requirement
Existing Proposed Total
i Furnace Oil (L/hr)
Boiler (4T) 250 -- 300
TFH-2LKcal 80 -- 80
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 1
M/s. Unichem Laboratories Ltd.
TFH-1 LKcal 50 -- 50
Boiler (5T) -- 300 300
Total 380 300 680
ii. HSD (L/hr)
DG 180 KVA 40 -- 40
DG 750 KVA 130 -- 130
DG 1250 KVA -- 250 250
DG 1250 KVA -- 250 250
Total 170 500 670
Note: The consumption of high speed diesel will depend on the actual hours of power
failure
13 Utility Capacity
Existing Proposed Total
i. 4 TPH boiler (Standby)
Boiler (T/hr) 4 5
5 TPH boiler (Primary)
ii DG 180 KVA
180 kVA 1250 kVA DG 750 KVA
D.G. Set
750 kVA 1250 kVA DG 1250 KVA
DG 1250 KVA
14 Water
Consumption 350 240 590
(CMD)
15 Scrubber Details
11 unit of alkali 3 units of alkali 14 units of alkali
scrubber scrubbers scrubbers
Scrubber
2 units of acidic 9 units of acid 11 units of acid scrubbers
scrubber scrubbers
16 Stack Details
i. Common stack 35 m for
Boiler Stack 35 m - existing and proposed
boiler
ii. 21 m 21 m
TFH stack --
23 m 23 m
iii. 5 m above roof All scrubber stacks shall
Scrubber Stack 3 m above roof
be 5 m above roof
iv. All DG set stacks shall
D.G. Set 3 above roof 3 m above roof
be 3 m above roof
17 Effluent Details
i Sewage (CMD) 40 -- 40
ii Effluent (CMD) 150 93 243
18 ETP Details
Existing Proposed Total
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 2
M/s. Unichem Laboratories Ltd.
i. ETP capacity
300 -- 300
(CMD)
Effluent stream segregation will be done in high load and low
load streams.
ETP consisting Pre-primary, Primary and secondary and
tertiary treatment. In this ETP low COD and Low TDS effluent
is being treated.
High COD and High TDS is being treated through Strippers 2
Nos., three stage Multiple effect evaporator (MEE) and
Agitator thin film dryer (ATFD). MEE condensate will be
mixed with low COD in aeration tank. Treated effluent from
ETP will be sent to Common Effluent Treatment plant for
further treatment.
ii. Effluent treatment For low TDS and Low COD Main collection Tank (500M3),
Neutralisation tank (50M3), Aeration Tank No. 01 (1000M3),
Aeration Tank No. 02 (650M3), Aeration Tank No. 03 (650
M3), and aeration tank no. 4 or Bioreactor (150M3), Clarifier
No. 1 (50M3), and Clarifier No. 2 (50M3), feed tank (100M3).
Pre tertiary tank (50M3), and post tertiary tank (50M3)Clarifier
No. 3 (50M3),
For High COD and TDS, collection Tank no. 1 (50M3),
collection Tank no. 2 (50M3), primary treatment tank No. 1
(15M3), tank No. 2 (15M3), and Primary treatment tank No. 3
(60M3), Stripper No. 1, Stripper No.2, Multiple Effect
Evaporator, (MEE) and Agitated Thin Film Drier.
Sewage will be treated in septic tank and the overflow will be
iii. Sewage treatment
mixed with process effluent in aeration tank of ETP.
Treated effluent is discharged to CETP. After expansion same
iv. Effluent disposal
practice shall be followed.
19 Details of Hazardous Waste
(vide Hazardous and Other Wastes (Management and Transboundary Movement)
Rules, 2016)
Particulars HW Existing Propose Total Method of Disposal
Categ
ory*
Used/spent oil 5.1 1 MT/A 2 MT/A 3 MT/A Sale to authorized
i. recyclers /Disposal to
CHWTSDF,
Distillation 4.5 7.5 Disposal to CHWTSDF, /
ii. 20.3 3 MT/A
residues MT/A MT/A Co-processing
Recycle, reuse/sale to
Spent 400 660
iii. 28.6 260 MT/A authorized recyclers
Solvents MT/A MT/A
/Disposal to CHWTSDF
Discarded Disposal to CHWTSDF,
4000
iv. containers 33.1 1000 5000 /Sale to authorized
Nos./A
barrels/liners/ recyclers
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 3
M/s. Unichem Laboratories Ltd.
plastic bags/
PPEs
Chemical
sludge from 35 Disposal to CHWTSDF, /
v. 35.3 18 MT/A 17 MT/A
wastewater MT/A Co-processing
treatment
Co-processing/ Sale to
Evaporator 5500 5500
vi. 37.3 -- authorized recyclers/
residue MT/A MT/A
Disposal to CHWTSDF,
42 Disposal to CHWTSDF, /
vii. Spent catalyst 28.2 20 MT/A 22 MT/A
MT/A authorized Co-processing
Date expired
viii. 28.4 1 MT/A 2 MT/A CHWTSDF
products
Off 2 MT/A
ix. specification 28.5 1 MT/A 2 MT/A CHWTSDF
products
Spent mother
x. -- 2 MT/A -- -- CHWTSDF
liquor
Ash from
incinerator
xi. and flue gas 37.2 1 MT/A 4 MT/A 5 MT/A CHWTSDF
cleaning
residue
Spent ion
exchange
1.5
xii. resin 35.2 0.5 MT/A 2 MT/A CHWTSDF
MT/A
containing
toxic metals
Spent carbon
19.5
xiii. or filter 36.2 0.5 MT/A 19 MT/A CHWTSDF
MT/A
medium
Waste/residue
xiv. 5.2 1 MT/A 1 MT/A 2 MT/A CHWTSDF
containing oil
Oil grease
xv. 35.4 -- 2 MT/A 2 MT/A CHWTSDF
skimming
Contaminated
cotton rags or
xvi. 33.2 -- 1 MT/A 1 MT/A CHWTSDF
other cleaning
materials
Residue and 81 CHWTSDF/ Authorized
xvii. 28.1 15 MT/A 66 MT/A
waste MT/A co processing company
20 Details of Non-Hazardous Waste
Particulars Existing Proposed Total Method of Disposal
I plastic waste Sale to MPCB approved
- 12 MT/A 12 MT/A
(Poly bags, HDPE scrap dealers/recyclers
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 4
M/s. Unichem Laboratories Ltd.
drums, HDPE
carboys)
2 Glass bottles -- 500 nos. 500 nos.
3 Fiber drums,
-- 5000 nos. 5000 nos.
wooden pallets
4 Paper waste, -- 5 MT/A 5 MT/A
5 MS/SS scrap, MS -- 50 MT/A 50 MT/A
drums
6 e-waste Waste
Particulars E Waste Existing Proposed Total Method of
Category Disposal
i Personal Computers
(Central Processing
ITEW2 -- 20 kg/A 20 kg/A
Unit with input and
output devices)
Sale to MPCB
ii Personal
authorised
Computing: Laptop
recycler/returne
Computers
ITEW3 -- 10 kg/A 10 kg/A d to
(Central Processing
manufacturer/su
Unit with input and
pplier
output devices)
iii Printers including
ITEW6 -- 3 kg/A 3 kg/A
cartridges
iv Telephones ITEW12 -- 1 kg/A 1 kg/A
21 Details of biomedical Waste
(vide Bio-Medical Waste (Management and Handling) Rules, 2016)
Particulars BMW Existing Proposed Total Method of
Category Disposal
i Soiled waste Disposal to
(Items contaminated CBMWTF/MPC
with blood, body fluids B authorized
like dressings, plaster processor for
Yellow -- 1 MT/A 1
casts, cotton swabs and Raigad region
bags containing residual
or discarded blood and
blood components)
ii Expired medicines
(Pharmaceutical waste
like antibiotics,
cytotoxic drugs
Yellow -- 1MT/A 1
including all items
contaminated with
cytotoxic drugs or
plastic ampoules)
iii) Microbiology, Yellow -- 2 MT/A 2
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 5
M/s. Unichem Laboratories Ltd.
Biotechnology and
other clinical
laboratory waste:
Blood bags, Laboratory
cultures, stocks or
specimens of
microorganisms,
live or
attenuated vaccines,
human and animal cell
cultures used in
research, industrial
laboratories, production
of biological, residual
toxins, dishes and
devices used for
cultures
22 Details of battery Waste
(vide Batteries (Management and Handling) Rules, 2001)
i Lead batteries from 20 Return to supplier/MPCB
-- 20 Nos./A
D.G. Sets, UPS system Nos./A authorized party
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 6
M/s. Unichem Laboratories Ltd.
2. Introduction of the project
Unichem Laboratories Ltd. was established with a vision to provide high quality Intermediates
and Active Pharmaceutical Ingredients to the global pharma industry.
The Active Pharmaceutical Ingredient (API) business requires strong infrastructure,
technological expertise, experience and capability to carry out contract manufacturing and
custom synthesis. Unichem provides customers a complete solution for API development,
starting from samples and trial quantities to regulatory assistance required for registration and
regulatory compliance.
The company’s facilities are designed to meet the highest global standards for API development
with a focus on complex APIs, controlled substances and APIs for regulated markets, all of
which are key to achieving Unichem’s strategic goals.
Roha site is located in an area 48885 m2, having multiple manufacturing plants. The site handles
many reactions such as Hydrogenation, Nitration, Ethoxylation, Grignard Reaction and various
types of unit processes
The site is also certified as per:
OHSAS 18001:2007 for Occupational health and safety.
ISO 14001:2015 for environmental compliance.
USFDA
EDQM
The project is located in plot no. 99, MIDC-Dhatav a notified industrial area by state
government of Maharashtra. The notification is attached as annexure-I. Dhatav MIDC lies
within 5 km distance of Dhatav village which is a notified eco sensitive area. Therefore the
project holds category “A” as the general condition is applicable to the expansion project.
However public hearing is exempted due to existence of the project in notified industrial area.
2.1 Expansion Details
As Unichem is 100% catering to the International markets, with increase in the demand in the
international markets company has planned capacity enhancement of the Roha unit. Expansion
of this project is for API and intermediates. The Existing Production Capacity is 377.77 MT/A
and Proposed Production Capacity after expansion shall be 500 MT/A. The industry expands
with the increase in capacity and proposed for the new products.(Total Capacity – 500 MT/A ;
660 MT/A byproducts)
2.2 Need of the Project and its importance to the country:
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 7M/s. Unichem Laboratories Ltd.
Proposal to enhance the manufacturing capacities of the existing plants and set up 01
independent plant for API intermediates which will be built as per cGMP requirements and
shall meet international standards set in by major regulatory authorities such as US FDA,
EDQM , TGA-Australia and others
Proposed enhancement is outcome of increase demand of API in the international markets /
internal consumers. Intermediates facility is being set up to cater the increase internal
demand of the same plant because of increase in API capacities as well as to reduce the
dependability from the external parties for intermediates.
Total Installed capacity of the plant will be 500 metric tons per Annum for all the plants put
together.
Facility shall comply with Gas Cylinder Rules & Petroleum storage Rules.
Fire alarm and gas/smoke detection system and escape routes shall be installed to meet the
requirements of relevant National Standards together with portable fire extinguishers as
necessary.
2.3 Demand supply gap:
International as well as Domestic demand of the various products proposed to be manufactured
by the company & the proposed installed capacity is as under
Sr. No. Product Name Production Qty. in International Domestic Demand
MT/A Demand in MT in MT
1. Amlodipine Besylate 11 Y Y
2. Amlodipine Maleate 2 Y Y
3. Apixaban 1 N Y
4. Aripiprazole 0.3 Y Y
0.5 N Y
5. Baclofen
6. Bendroflumethiazide 2 Y Y
7. Bisoprolol Fumarate 10 Y Y
Buprenorphine 0.5 Y Y
8.
Hydrochloride
Clonidine 0.5 Y Y
9.
Hydrochloride
Donepezil 0.5 Y Y
10.
Hydrochloride
11. Doxazosin Mesylate 1 N Y
12. Hydrochlorothiazide 130 Y Y
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 8M/s. Unichem Laboratories Ltd.
Labetalol 5 N Y
13.
Hydrochloride
14. Lacidipine 0.5 Y Y
15. Meloxicam 12 Y Y
16. Metronidazole 250 Y Y
17. Paliperidone 0.5 Y Y
18. Piroxicam 0.5 Y Y
Pramipexole 0.2 Y Y
19. dihydrochloride
monohydrate
Prasugrel 0.5 Y Y
20.
Hydrochloride
21. Rivaroxaban 1 Y Y
22. Rizatriptan Benzoate 0.5 N Y
23. Solifenacin succinate. 0.2 N Y
24. Tadalafil 0.5 N Y
Tamsulosin 0.5 N Y
25.
Hydrochloride
Teneligliptin 0.5 N Y
26.
Hydrobromide
27. Teriflunomide 0.5 Y Y
Tigagibine 0.5 N Y
28.
Hydrochloride
Tizanidine 0.2 Y Y
29.
hydrochloride
30. Tofacitinib citrate. 0.5 N Y
31. Tolterodine Tartrate 0.2 N Y
Vortioxetine 0.5 N Y
32.
Hydrobromide
33. Zolmitriptan 0.2 N Y
4-( 4-fluorobenzoyl ) 60 Y N
butyric acid ( Keto
34.
Acid )
IDN(Taxol) 0.5 Y N
35.
R & D Product 5.0 Y Y
36.
Imports vs. Indigenous Product:
The raw material is imported as well as purchased indigenously. The major raw materials are
domestically purchased some of the specialty chemicals required as raw material are imported
due to manufacturing shortfall in the domestic market.
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 9M/s. Unichem Laboratories Ltd. Export possibility: Regulated market like US, EU & RoW Expected Sales out of the above products- The estimated sales out of the above products are given hereunder: (Rs. In crs) Sr.No. Name Of Products Name Of Products 1. Amlodipine Besylate 2. Amlodipine Maleate 3. Bisoprolol Fumarate 4. Clonidine Hydrochloride 5. Doxazosin Mesylate 6. Labetalol Hydrochloride 7. Lacidipine 8. Bendroflumethiazide 9. Hydrochlorothiazide 10. Aripiprazole 11. Paliperidone 12. Tigabine Hydrochloride Rs.140 Crores 13. Apixaban 14. Rivaroxaban 15. Baclofen 16. Buprenorphine Hydrochloride 17. Donepezil Hydrochloride 18. Piroxicam 19. Meloxicam 20. Metronidazole 21. Pramipexole dihydrochloride monohydrate 22. Prasugrel Hydrochloride 23. Zolmitriptan M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 10
M/s. Unichem Laboratories Ltd.
24. Rizatriptan Benzoate
25. Solifenacin succinate.
26. Tadalafil
27. Tamsulosin Hydrochloride
28. Teneligliptin Hydrobromide
29. Teriflunomide
30. Tizanidine hydrochloride
31. Tofacitinib citrate.
32. Tolterodine Tartrate
33. Vortioxetine Hydrobromide
34. 4-( 4-fluorobenzoyl ) butyric acid ( Keto Acid )
35. IDN(Taxol)
36. R & D Products
Total Rs. 140 Crores
Employment generation:
The proposed expansion will generate employment for skilled as well as non-skilled labour.
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 11M/s. Unichem Laboratories Ltd.
3. Project Description
(I) Non-violation of EIA notification, 2006
The existing API and intermediates manufacturing project is located in the notified industrial
area-MIDC, Dhatav. Valid consent to operate : ‘Formate 1.0/ BO/CAC-Cell/ EIC No RD-3222-
16/14th CAC/3317’ dated 08.03.2016 valid up to 30.04.2020. Existing API and intermediates
manufacturing capacity of the production unit is 377.77 MT/A. The valid CTO is attached as
annexure V. Existing unit is established in 1994. therefore the unit does not hold prior EC. The
manufacturing capacity of the plant is unchanged since 2006. The CTO of the plant of
21.04.2004 is attached as annexure VI .
The existing unit complies with the applicability of EIA notification, 2006 and does not comes
under violation of EIA notification, 2006.
The Proposed Expansion is in the existing plant so no alternate site is considered.
(II) Size or Magnitude of Operation:
Sr Product Name Therapeutic Existing (MT/A) as Proposed Total
No. Category per consent (MT/A) (MT/A)
1.0/BO/CAC-
Cell/EIC No. RD-
3222-16/14th
CAC/3317
1. Amlodipine 20.0 -9 11
Besylate
2. Amlodipine -1 2
Maleate
3
3. Bisoprolol 8.00 2 10
Fumarate Anti-
Hypertensive
4. Clonidine 0.25 0.25 0.50
Hydrochloride
5. Doxazosin 0 1 1
Mesylate
6. Labetalol 5 0 5
Hydrochloride
7. Lacidipine 0.02 0.48 0.5
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 12M/s. Unichem Laboratories Ltd.
8. Bendroflumethiazi Anti- 2 0 2
de Hypertensive,
9. Hydrochlorothiazi Diuretic 60 70 130
de
10. Aripiprazole 0.2 0.3 0.5
11. Paliperidone Anti-psychotic 00 0.5 0.5
12. Tigabine 0.02 0.48 0.50
Hydrochloride
13. Apixaban Anticoagulant 0 1 1
14. Rivaroxaban 0 1 1
15. Baclofen muscle relaxant 0 0.5 0.5
and antispastic.
16. Buprenorphine Post operative 0.02 0.48 0.50
Hydrochloride analgesic
17. 0 Donepezil Anti Alzheimer 0.08 0.42 0.5
Hydrochloride (In treatment of
Nootropic)
18. Piroxicam Anti 0 0.5 0.5
Inflammatory
19. Meloxicam Anti 5 7 12
Inflammatory
20. Metronidazole Anti Protozoal, 269 -19.0 250
Anti Amoebic
21. Pramipexole Anti- 0.02 0.18 0.2
dihydrochloride Parkinsonian
monohydrate
22. Prasugrel Antithrombotic 0 0.5 0.5
Hydrochloride and Antiembolic
agents, Platelet
Aggregation
Inhibitors
23. Zolmitriptan Anti migraine 0.02 0.18 0.2
24. Rizatriptan 0.01 0.49 0.5
Benzoate
25. Solifenacin Treatment of 0 0.2 0.2
succinate. overactive
bladder in adults
with symptoms
of urge urinary
incontinence,
urinary urgency
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 13M/s. Unichem Laboratories Ltd.
and urinary
frequency.
26. Tadalafil Erectile 0 0.5 0.5
Dysfunction
27. Tamsulosin In treatment of 0.01 0.49 0.5
Hydrochloride benign prostatic
hypertrophy.
28. Teneligliptin Antidiabetic 0 0.5 0.5
Hydrobromide
29. Teriflunomide Multiple 0 0.5 0.5
sclerosis (MS)-
pyrimidine
synthesis
inhibition
30. Tizanidine Muscle relaxant 0.05 0.15 0.20
hydrochloride
31. Tofacitinib citrate. Rheumatoid 0 0.5 0.5
arthritis
32. Tolterodine Anti-muscarinic 0.05 0.15 0.2
Tartrate
33. Vortioxetine Antidepressant 0 0.5 0.5
Hydrobromide
34. 4-( 4- 0 60 60
fluorobenzoyl )
butyric acid (
Keto Acid )
35. IDN(Taxol) 0 0.5 0.5
36. R & D Product 0 5.0 5.0
37. Brimonidine Anti-Glaucoma 0.02 0 0
tartrate
38. Finofibrate Anti-Hyper 5 0 0
lipidemic
Total production 377.77 127.25 500
By-products
1. Spent solvent -- 660 660
(III) Manufacturing process details of Processes with flow charts:
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 14M/s. Unichem Laboratories Ltd.
The manufacturing process with material balance of major product is attached as Annexure II.
(IV) List of the Raw Material with Quantity & Import Local Details:
List of raw materials with quantity required for manufacturing all products are attached as
Annexure III
(V) Resource optimization/recycling and reused envisaged in the project, if, should be
briefly outlined.
Maximum focus will be given during the project to ensure optimization of resources and reuse
wherever possible. Following are few initiatives which are planned during the project:
Solvent recovery system – Solvent recovery system is being set up to recover the solvents
used in the process so that it can be reused. This will help in terms of reduction in the
hazardous waste as well as reduction in VOC emissions.
Salt sale as by product – Salts generated during the process is planned to sell to other
industries that can use it as raw material. This will help in terms of reduction in
hazardous waste quantities as well ensure use of the resource.
Steam condensate recovery – Steam condensate recovery to planned to implement which
can help in terms of reduction in water consumption, reuse of the energy and their by
reduction in fuel consumption.
Co processing of hazardous waste – It is planned to send the hazardous waste generated
during the processed to authorized co processing companies e.g. Cement Industries who
can use it as fuel. This will help to reduce the burden on the environment as well as
conservation of resource
(VI) Water Requirement-Source: MIDC
Existing Water Requirement: 350 CMD
Proposed Water Requirement: 590 CMD
Water Budget:
Sr. Activity/Process Existing Project After expansion
No.
Quantity Loss Effluent Quantity Loss Effluent Recycle
of Water of Water
Required Required
in CMD in CMD
1 Domestic 50 10 40 50 10 40
2 Process 180 62 118 130 0.2 141
scrubber 15 3 12
3 Industrial cooling 80 48 32 245 210 35
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 15M/s. Unichem Laboratories Ltd.
Boiler feed 100 25 55 20
4 Green belt 40 40 50 50 0
TOTAL 350 160 190 590 298.2 283 20
Power Requirement-Source: MSEB.
Connected Load: 4000 + KW (Existing) + 2000 KW (Proposed )
Existing Power Demand 2550 KVA + Proposed Power Demand: 1500 KVA
Utility details
Alternate Source for Power: DG SET
1. Capacity : 750 KW x 1 nos (Existing)
: 180 KW x 1 nos (Existing)
1500 KW x 2 nos (Proposed)
Fuel requirement – 670 liter / hr.
2. Fuel Type: HSD
3. Consumption: HSD : 3000 L/day (D.G. Set will only be operational during power
failure)
1. Characteristics of the effluent
Parameters Inlet effluent Outlet effluent Effluent Discharge
(pH, BOD, Characteristic Standards (CPCB/MPCB)
Charact-eristic
COD, etc.)
pH 2.5 to 3 5.5 to 9
BOD 7000 mg/L < 100 mg/LM/s. Unichem Laboratories Ltd.
Design of Existing Effluent Treatment Plant: Biological Treatment Plant
Sr. No Unit Quantity Capacity MOC
1 Screen Chamber 1 0.5 Kl RCC
2 Oil trap 2 1 Kl RCC
3 Main Equalization Tank 1 500 Kl RCC
4 Primary Tank 1 40 Kl RCC
5 Feed Balance Tank 1 100 Kl RCC
6 Aerator 1 1000 Kl RCC
7 Aerator 2 650 Kl x 2 RCC
8 Clarifier 1 50 Kl RCC
9 Clarifier 2 40 Kl x 2 RCC
10 Treated Water Tank 2 50 Kl x 2 RCC
11 Pressure sand Filter 2 5 M3/hr RCC
12 Activated Carbon Filter 2 5 M3/hr RCC
13 Sludge Drying bed 6 RCC
14 V-Notch 1 0.5 Kl RCC
15 BR Tank 3 50 kl RCC
Proposed MEE / ATFD Plant
Sr.no Description Quantity Capacity MOC
1 High TDS collection 2 50KL RCC
tank
2 Neutralization tank 3 15 Kl RCC
3 Feed Balance tank 2 1 Kl MS
4 Stripper Column 2 MS
5 Solvent collection tank 1 1Kl MS
6 MEE Feed Tank 1 1Kl MS
5 MEE Effect 3 40 M3 SS316 Ti
6 ATFD 2 MS
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 17M/s. Unichem Laboratories Ltd.
7 ATFD Main collection 2 32 Kl RCC
Tank
8 ATFD feed balance 1 0.8 Kl MS
Tank
9 Process condensate 1 15 Kl MS
Tank
10 Seal Cooling Tank 1 1 Kl Ms
11 CIP Tank 1 7 Kl MS
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 18M/s. Unichem Laboratories Ltd.
(X) Schematic Representation of the Feasibility Drawing of EIA
RESOURCE CONSUMPTION POWER CONSUMPTION
(WATER)
RAW MATERIAL
PRODUCTION ACTIVITY
WASTE GENERATION
FINISHED PRODUCTS
Hazardous Waste
Emission Effluent
s
CHWTDSF
Scrubber
TALOJA
Proposed ETP
MARKET
25 CMD
EMPLOYMENT
POLLUTION ABATEMENT
ABATEMENT
ECONOMY
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 19M/s. Unichem Laboratories Ltd.
4. Site Analysis
This industry is located in Dhatav MIDC Roha
I. Connectivity: Distance from Industrial Area
Nearest railway station : Roha 05 Km
Nearest Airport: 120 km. Mumbai Airport.
Location and Access
The industrial area is centrally located and easily accessible through all modes of
transport
Road: The entire industrial area is well connected by internal roads Available Road
Network: State Highway No.17 –Mumbai-Goa within 10 km from the site.
Railway: Roha Railway Station is in close proximity, situated about 5 Km. away from
area.
Air: Mumbai Air Port is located, around 120 Km away from the site.
II. Land Form, Land use and Land Ownership: The Project location is in the notified
industrial zone i.e. MIDC Dhatav Roha.
Topography: The location of industry is in notified Area. The land is developed by MIDC and
infrastructure provided by MIDC.
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2. Latitude : 18°43'16.10"N
3. Longitude : 73°15'20.94"E
4. Location : Plot No. 99 MIDC Dhatav Roha 402116.
5. Elevation above Mean Sea Level (meters): 582 meters
III. Existing project and proposed project are in the same premises located in Dhatav
Roha 402116.
IV. Existing Infrastructure:
The industry is having the facilities like canteen, lavatory and assembly hall, utility
Department, Garden etc.
V. The Attached Plant Lay out - Annexure IV
VI. Soil Classification
The physical setting of the Raigad district is divided into three main parts namely
Eastern ranges, Central ranges and Southern ranges. Eastern and Central ranges have
black soil formed from 'lava' and at some places it has large tracks of fertile land. The
western ranges are mostly hilly and have red soil. The majority area in the west is under
thick forest coverage.
Climatic data (Secondary source)
VII. Raigad climate is a blend of coastal and inland elements common to Maharashtra. The
temperature has a relatively narrow range between 10 °C to 35 °C. Summer in Raigad is
comparatively hot, but much more humid, than neighbouring inland cities. Maximum
temperatures rarely exceed 40 °C and typically range between 33 and 35 °C. Lows during
this season are around 24 °C to 26 °C. The year is divided into four seasons; the summer
– March to May, the rainy – June to September, the post monsoon – October to
November & the winter - December to February
VIII. Social Infrastructure available:
Hotels, Motels, sports ground, public ground, public garden, petrol pumps, school,
hospital, roads, railway station is available around the project location.
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5. Planning Brief
The total Plot area is 48885 sq. m. The green belt area will be 6790 sq. m. New infrastructure
will be erected. Power supply will be taken from MSEB and water supply will be provided by
MIDC. In the industry premises demarcated storage area will available for the raw material and
finished product. The industry will have lavatory and garden etc. In the industry all necessary
safety and firefighting equipment’s like Hydrant, Sprinkler, Detector System, Fire Extinguishers.
6. Proposed Infrastructure
(i) Industrial Area: MIDC, Dhatav, Roha, Raigad – 402116 - Maharashtra state.
(ii) Residential Area: Not applicable.
(iii) Green Belt: Nil.
(IV) Social Infrastructure and (V) Connectivity
Road: MIDC has provided asphalt roads with widths varying from 3.75 to 16 m; these
are mainly two lane roads with a central verge of bougainvillea
Water: MIDC supply.
consumption of water would be 350 CMD, (Existing –350 & Proposed – 240 )
Electricity:
Existing: - Connected load: 3996 kW
Maximum Demand: 2550 KVA
Proposed: - Connected load: 2000 kW
Maximum Demand: 1500 KVA
Streetlights: MIDC has provided street lighting facility in the area;
Telecommunication Facility / Connectivity: Fax, telex, email and Internet facilities
are available. A telephone exchange is located in the area.
Fire Station: A fire station is 1 KM distance.
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Common Effluent Disposal Facility: MIDC has constructed a common effluent
treatment plant of capacity 22 MLD
(VI) Source of the Water will be MIDC. The daily water requirement will be 350 CMD
(Existing – 350 & Proposed – 240)
(VII) Domestic Waste water will be treated in the effluent treatment plant
(VIII) The Industrial Waste will be disposed of to CHWTSDF Taloja.
(IX) The non-hazardous Solid Waste generated like empty drums will be returned to
manufacturer.
(X) The Power Requirement:
Existing: - Connected load: 3996 kW
Maximum Demand: 2550 KVA
Proposed: - Connected load: 2000 kW
Maximum Demand: 1500 KVA
7. Rehabilitation & Resettlement (R & R) Plan: Not Applicable. The expansion project shall
be executed on the existing plot located in notified industrial area MIDC-Dhatav.
8. Project Schedule & Cost Estimates
1. The proposed schedule for approval and implementation.
Sr. Description Time Cost in %
No.
1. Obtaining all statutory permission with 7 Months 2%
respect to industry
2. Design and Engineering Plan 3 Months 15%
3. Factory Set Up 8 Months 70%
4. Testing and Commissioning 1 Months 13%
5. Actual Starting 1 Months --
Estimated project cost along with analysis of economic viability of the project.
The infrastructure already exists but for implementation of the new project the minor
Construction will be required.
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9. Analysis of proposal (Final Recommendations)
The project will provide employment opportunities to local people and it will increase the
living standard. As the industry has the export market it will add to the net foreign exchange
earning of the country. In view of the above points it is concluded that the project proposal will
not have any negative impact on the environment and people on the other hand will have positive
impact by improving the socio economic aspects with employment generation.
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Annexure I- Notified Industrial Area MIDC –Dhatav Gazette
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Annexure II- Manufacturing details
1. Metronidazole
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Annexure III- Raw material Details
Sr. Raw Material Existing Proposed Imported
No. Qty. Qty. /Local
1 Methanol 180643 744690 LOCAL
2 (IDN-IV) (IDN 6003) 0 485.0 LOCAL
3 (S) -4- (4 Amniobenzyl)-2-Oxazolidinone 38.07 380.71 IMPORT
4 (R)-(+) α-Methyl Benzylamine 29.21 1460.5 LOCAL
5 (S)-(+ )-glycidyl pthalimide 0 1602.9 LOCAL
6 (S)tetrahydroisoquinolineTartrate SLF -I 0 297.5 LOCAL
7 (R)-(-)-3-Quinuclidinol 0 108.5 LOCAL
8 10% Palladium on Charcoal 12.33 428.30 LOCAL
9 1-methyl-3-phenylpropylamine (MPPA) 25249.60 25249.60 IMPORT
10 1-Bromo-4-Chlorobutane 926.47 2316.18 LOCAL
11 1-(2,3-Dichlorophenyl) Piperazine 344.49 861.21 LOCAL
12 10% Palladium on Carbon (Type 39K Paste) 7.79 389.5 LOCAL
13 2-(2-Ethoxyphenoxy) Ethyl Bromide 14.33 716.36 LOCAL
14 2,2-Azobisisobutyronitrile 0 24.8 LOCAL
15 1,2-Dichloro benzene 0 3950.3 LOCAL
16 2-Amino-5-Methyl thiazole 2094.41 5026.60 LOCAL
17 2,6-Dichloroaniline 452.24 904.49 IMPORT
18 2,4-Dinitroaniline 65.15 65.15 LOCAL
19 2-Bromobenzaldehyde 12.29 614.49 IMPORT
20 2,4-Dimethoxy Benzaldehyde 0 279.02 IMPORT
21 2-Amino pyridine 0 295.7 LOCAL
22 2,6-di-tert-butyl-4-methyl phenol (BHT) 0 14.9 LOCAL
23 2,4-Dimethyl thiophenol (DMTP) 0 870.3 LOCAL
24 2-Methyl Imidazole (Crude) Stage-I 815717.35 758101.85 LOCAL
25 2-METHYL IMIDAZOLE -IV(PURE) 489430.41 454861.11 LOCAL
26 2-MNI (Crude) 927800.65 862268.51 LOCAL
27 3-(2-methoxy-5-methylphenyl)-3-phenylpro 193.30 773.2 IMPORT
28 2-Nitrophenyl Sulphenyl Chlo. (IDN 5954) 0 280.1 LOCAL
3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-
9-hydroxy-4H-pyrido[1,2-a ]pyrimidine-4-one
29 (CMHTP) 0 735.8 IMPORT
30 2-Oxothienopyridine 0 1061.1 LOCAL
31 2-Chloro nitro benzene (CNB) 0 992.2 LOCAL
32 2-butanol 0 21648.4 LOCAL
33 2-Phenylethyl amine (PEA) 0 300 LOCAL
34 4-Hydroxy Benzaldehyde 7285.97 9107.47 IMPORT
35 4-Amino-5-Chloro-2,1,3-Benzothiadiazole 180.79 723.2 LOCAL
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36 5,6-Dimethoxy-1-Indanone 80.39 502.45 LOCAL
37 5-Chloro Acetyl Salicylamide (5-CAS) 7234.84 7234.84 LOCAL
38 5-Acetonyl-2-Methoxy Benzene Sulfonamide 58.42 2921.1 LOCAL
39 5% Platinum on Carbon (Type 18K Paste) 2.60 129.8 LOCAL
40 4-Amino-6-Chloro-1,3-Benzene 73972.60 160273.97 LOCAL
41 4-Trifluoromethyl Aniline (ForTRF) 0 457.4 IMPORT
42 4-hydroxycoumarin 0 LOCAL
43 4-(4-aminophenyl) morpholine-3-one 0 1367.4 LOCAL
44 Acetaldehyde 535509.1 497685.18 LOCAL
45 Acetone 101100 220316 IMPORT
80 %
LOCAL 20
%
46 Acetonitrile 495 50471 LOCAL
47 7-Hydroxy-3,4-Dihydrocarbostyril 294.12 735.29 LOCAL
48 Acetice acid 0 57.75 LOCAL
6-Fluoro-3-piperidino-1,2-benzisoxazole
49 hydrochloride (FBIP. HCL) 0 677.5 IMPROT
50 Acetic Anhydride 0 1140.5 LOCAL
51 5-Methylisoxazole-4-carboxylic acid 0 328.0 IMPORT
52 5-chlorothiophene-2-carboxylic acid 0 813.3 LOCAL
53 Activated Charcoal (Neutral) 12461 85084.0 LOCAL
54 Alcohol with 5% Acetone 993.89 24847.32 LOCAL
55 Acetyl Chloride 0 67769.90 LOCAL
56 Amberlyst-15 (Cation Exchange Resin ) 6338.80 7923.50 IMPORT
57 AMB-I 21717.00 12271.00 INHOUSE
58 Ammonium Thiocyanate 376 992.00 LOCAL
59 AML-II 22717.39 12494.57 INHOUSE
60 Aluminium Oxide Neutral 643 4020.00 LOCAL
61 Ammonium Chloride 537 13439.00 LOCAL
62 Ammonium carbamate 18.22 910.74 LOCAL
63 Aluminium Chloride Anhydrous 0 117352.25 LOCAL
64 AlFuzsoin Hydrochloride 0 660.8 LOCAL
65 Aqueous Monomethylamine (40%) (AMA) 140832 79583.00 LOCAL
66 Anhydrous Sodium Bicarbonate 578 LOCAL
67 Anhdyrous Sodium Carbonate 9 4047.00 LOCAL
68 Anhydrous Sodium Bicarbonate 570.31 2214.90 LOCAL
69 Anhydrous Sodium Sulphate 64.16 3153.60 LOCAL
70 APX-I 0 1688.5 INHOUSE
71 APX-II 0 1213.1 INHOUSE
72 Aripiprazole Stage-I 391.18 977.94 INHOUSE
73 Aripiprazole Stage-II (Crude) 587.50 1468.75 INHOUSE
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 37M/s. Unichem Laboratories Ltd. 74 BCL-I 0 1344.4 INHOUSE 75 BCL-II 0 645.31 INHOUSE 76 BDCP 0 759.5 INHOUSE 77 Bendro Amide 1714.29 1714.29 LOCAL 78 Bendroflumethiazide Crude (BNZ-Stage I) 2666.67 2666.67 LOCAL 79 Benzene Sulphonic Acid 8804.35 4842.39 LOCAL 80 BFU-I 6338.80 7923.50 INHOUSE 81 BFU -II 7992.71 9990.89 INHOUSE 82 Benzeneamine derivative 38.46 1923.1 LOCAL 83 Benzoic acid 14.00 700.0 LOCAL 84 beta picoline 0 455.38 LOCAL 85 Benzoyl Chloride 641.00 2015.50 LOCAL 86 Bisoprolol Fumarate (BFU-III)(Crude) EU 9500.91 11876.14 LOCAL 87 Bis(2-chloro ethyl) amine hydrochloride 0 940.8 LOCAL 88 Boron Trifluoride Etherate 751.94 3842.80 LOCAL 89 Brimonidine Tartarate Stage I 55.37 55.37 INHOUSE 90 Brimonidine Tartarate Stage II 34.92 34.92 INHOUSE 91 Brimonidine Tartarate StageIII 34.92 34.92 INHOUSE 92 Brimonidine Tartarate StageIV 33.16 33.16 INHOUSE 93 Bromobenzene 634.53 634.53 LOCAL 94 Brimonidine Tartarate Stage - V 19.41 19.41 INHOUSE 95 Brimonidine Tartarate Stage VI 14.92 14.92 INHOUSE 96 Buprenorphine Hydrochloride Stage-II 194.50 4862.42 INHOUSE 97 Buprenorphine Hydrochloride Stage-III 171.14 4278.52 INHOUSE 98 Buprenorphine Hydrochloride Stage-V 61.61 1540.27 INHOUSE 99 Buprenorphine Hydrochloride Stage-VI 53.89 1347.32 INHOUSE 100 Buprenorphine Hydrochloride Stage-VII 42.62 1065.44 INHOUSE 101 Buprenorphine Hydrochloride Stage-VIII 37.52 937.92 INHOUSE 102 Buprenorphine Hydrochloride Stage-IX 26.64 666.11 INHOUSE 103 Butylated Hydroxytoluene (BHT) 17.00 45.00 LOCAL 104 Calcium Chloride 61.58 1088.42 LOCAL 105 Caustic Lye-46% 1274893.00 1273758.00 LOCAL 106 Cetrimide 54.76 135.10 LOCAL 107 Chloroacetyl chloride (CAC) 0 554.3 LOCAL 108 Chloroform 65733.00 140511.00 LOCAL 109 Citric Acid Monohydrate 0 463.8 LOCAL 110 Clonidine Hydrochloride Stage-I 493.85 987.70 INHOUSE 111 Clonidine Hydrochloride Stage-II 469.07 938.13 INHOUSE 112 Conc. Nitric Acid 446589.88 415046.29 LOCAL 113 Conc.HCL 39.22 4146.74 LOCAL 114 Conc.Hydrochloric acid 0 1124.14 LOCAL M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 38
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115 Cyanogen Bromide 22.15 553.69 LOCAL
116 Cyclohexane 219.19 5479.87 LOCAL
117 Cyclopropyl Methyl Bromide 16.71 417.79 IMPORT
118 Cyclopropyl-2-fluorobenzylketone 0 992.1 LOCAL
119 D (-) Mandelic Acid 16.88 843.9 LOCAL
120 D(-) Tartaric acid 0 370 IMPORT
121 Denatured Ethyl Alcohol 1143.62 28590.60 LOCAL
122 Denatured Ethyl Alcohol with 5% Acetone 1534.90 38372.48 LOCAL
123 Di Isopropyl Ether 2161.57 13509.8 LOCAL
124 Diazo bicyclo Undacane 0 518.3 LOCAL
125 Diazo Bicyclo Undacane (DBU) 0 332.6 LOCAL
126 Diethylene Glycol 1390.20 34755.03 LOCAL
127 Dimethyl Sulphate 560.56 1412.6 LOCAL
128 Diisopropylamine 289.95 1159.8 LOCAL
129 Dimethyl Glutarate 0 67769.90 IMPORT
130 Dimethyl formamide 0 10704.9 LOCAL
131 Donepezil Hydrochloride Stage-I 140.71 879.41 INHOUSE
132 Donepezil Hydrochloride Stage-II 120.63 753.92 INHOUSE
133 Donepezil Hydrochloride Stage-III 108.78 679.90 INHOUSE
134 DMN -IV 77.24 1544.72 LOCAL
135 Epichlorohydrine 25355.19 31693.99 IMPORT
80 %&
LOCAL 20
%
136 EDPTSA SALT 1516.08 3742.00 LOCAL
137 DXZ-I 0 1025.3 INHOUSE
138 D-Tryptophan methyl ester hcl (DTME) 0 833.3 IMPORT
139 Ethanol (for TNL) 0 4234.1 LOCAL
140 Ethanol Anhydrous 78122.06 162358.0 LOCAL
141 Ether (Diethyl Ether) 768.72 19218.12 LOCAL
142 Ethyl Acetate 14899.25 376151.0 LOCAL
143 Ethyl Acetate (Hyflow Preparation ) 733.33 14666.67 LOCAL
144 Ethyl Acetoacetate 25.31 1265.21 LOCAL
145 Ethyl chloroformate 0 595 LOCAL
146 Ethyl cyano acetate (ECA) 0 659.9 LOCAL
ETHYL-3-AMINO CROTONATE (FOR
147 LACIDIPINE) 21.51 1075.36 LOCAL
148 Ethylene Diamine 647.31 1555.90 LOCAL
149 Ethylene Oxide 420312.5 390625.00 LOCAL
150 Fluorobenzene 0 344302.60 LOCAL
151 Formic Acid 99% 7.91 395.46 LOCAL
152 Fumaric acid 1623.85 2217.64 IMPORT
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 39M/s. Unichem Laboratories Ltd. 153 Glacial Acetic Acid 597781.00 623816.00 LOCAL 154 Glacial Acetic Acid (21.0-31.5 KG ) 148.31 593.2 LOCAL 155 Glyoxal 40% 1731064.3 1608796.29 LOCAL 156 Glyoxal Sodium Bisulphite 124.23 124.23 LOCAL 157 Hydrazonyl Chloride 0 1770.5 LOCAL 158 Hydrobromic Acid 1654.64 9096.4 LOCAL 159 Hydrochloric Acid (Commercial) 42045.95 284681.11 LOCAL 160 Hydrochlorothiazide Crude (HCT-I) 72945.21 158047.95 INHOUSE 161 Hydrogen Gas 108.39 2164.51 LOCAL 162 Hydroquinone 7.87 15.1 LOCAL 163 Hyflow Supercell 3892.6 12676.23 LOCAL 164 Iodine Crystals 0.43 10.74 LOCAL 165 Isopropyl Alcohol 398237 267584 LOCAL 166 Isoamyl Alcohol 5005.43 10010.85 LOCAL 167 Isopropanolic HCl (25%) (IPA.HCl) 99.2 3757.7 LOCAL 168 Isopropyl Amine 16626.59 20783.24 LOCAL 169 Keto acid (KTD-I) 0 44917.26 INHOUSE 170 Keto Acid Stage-II 0 80000.00 INHOUSE 171 KSM-I 0 1131.2 INHOUSE 172 L (+) Tartaric acid 144.59 1700.32 LOCAL 173 LABETALOL HYDROCHLORIDE (LBL-I) 7596.59 7596.59 INHOUSE 174 LABETALOL HYDROCHLORIDE (LBL-II) 6190.86 6190.86 INHOUSE 175 Lacidipine Stage-I (Br-DHP) 18.12 906.21 INHOUSE 176 Lacidipine Stage-II 10.87 543.34 INHOUSE 177 Liquid Bromine 38.44 38.44 LOCAL 178 Liquor Ammonia (25%) 6491579.00 6073924.00 LOCAL 179 Magnesium Turnings 39.36 984.06 LOCAL 180 Maleic acid 875.27 583.51 LOCAL 181 malonic acid 0 1100.69 LOCAL 182 MDC 0 16993.00 LOCAL 183 Metane sulphonic acid 0 251.9 LOCAL 184 Methanolic Ammonia 0 13819.7 LOCAL 185 Methelene chloride 14318 533057.00 LOCAL 186 Methyl benzothiazine Isopropyl Ester 5551.86 14106.00 LOCAL 187 Metronidazole (Crude) Stage-I 358666.67 333333.33 INHOUSE 188 MNI Crude Stage-III (DRY) 747222.22 694444.44 INHOUSE 189 Morpholine Dilactam 0 1639.3 LOCAL 190 MTZ-II 286933.33 266666.67 INHOUSE 191 MTZ-III 269000 250000.00 INHOUSE 192 MXM-I 5884.31 14122.34 INHOUSE 193 N,N-Dimethylformamide 20117 28559.46 LOCAL M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 40
M/s. Unichem Laboratories Ltd. 194 N.N-Dimethyl-4-Aminobutanal Diethyl Acet 107.9 3110.90 LOCAL 195 N-Benzylpiperidine-4-Carboxaldehyde 100.47 627.94 LOCAL 196 N-Bromosuccinimide 0 1091.3 LOCAL 197 n-Butanol 0 24020.00 LOCAL 198 Neutral Alumina 7992.71 9990.89 LOCAL 199 n-Heptane 551.55 2206.2 LOCAL 200 n-Hexane (Petroleum Fraction) 5271.00 33133.00 LOCAL 201 Nitrogen Gas 1352.00 41298.00 LOCAL 202 Nitromethane 0 3065.2 LOCAL 203 Oleum 65% 1855601.85 1724537.03 LOCAL 204 O-Xylene 33204.79 88721.00 LOCAL 205 Palladium Acetate 0.36 18.11 LOCAL 206 Palladium on Carbon - 5% 2.42 53.90 LOCAL 207 Paraformaldehyde 8835.62 19143.84 LOCAL 208 Perchloric acid 70% 0 1642.1 LOCAL 209 Phenylacetaldehyde Dimethylacetal 1485.71 1485.71 LOCAL 210 Phosphorus Oxychloride 0 570 LOCAL 211 Phosphorus Pentoxide (P2O5) 0 270 LOCAL 212 Phthaloyl Amlodipine 31214 17639 LOCAL 213 piperidine 0 138.44 LOCAL 214 Piperonal (PPN) 0 521.0 LOCAL 215 Piroxicam crude (PRC-I) 0 703.7 INHOUSE 216 PLP-I 0 609.8 INHOUSE 217 Polyethylene Glycol 400 360.29 900.74 LOCAL 218 Potassium Carbonate 911 9741.0 LOCAL 219 Potassium Hydroxide 116.78 4062.0 LOCAL 220 Potassium Iodide 1.69 175.5 LOCAL 221 Pra chloro benzaldehyde 0 1144.167 LOCAL 222 Pramipexole Stage-I (PRM-I) 21.63 432.52 INHOUSE 223 Pramipexole Stage-II 22.68 453.66 INHOUSE 224 Pramipexole Stage-III 15.85 317.07 INHOUSE 225 Pramipexole Stage-IV 11.14 222.76 INHOUSE 226 Propionic Anhydride 16.67 333.33 LOCAL 227 PRS-I 0 1388.9 INHOUSE 228 PRS-II 0 625.4 INHOUSE 229 PRS-III for seeding 0 1.6 INHOUSE 230 p-Toluene Sulphonic Acid 1879.7 4642.2 LOCAL 231 Pure 2-Isopropoxy Ethanol 87333.33 109166.67 LOCAL 232 Raney Nikel Catylst 0 458.0 LOCAL 233 Rivaroxaban Stage I (RVR-I) 0 2359.1 INHOUSE 234 Rivaroxaban Stage II (RVR-II) 0 1946.5 INHOUSE M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 41
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235 Rivaroxaban Stage III (RVR-III) 0 1367.4 INHOUSE
236 Rivaroxaban Stage IV (RVR-IV) 0 1332.9 INHOUSE
237 Rizatriptan benzoate crude (RZT-I) 15.38 769.2 INHOUSE
238 Silica gel 488 23607.0 LOCAL
239 Sodium Acetate Trihydrate 51.01 51.01 LOCAL
240 Sodium Bicarbonate 9.93 347.6 LOCAL
241 Sodium Bisulphate 0 492.7 LOCAL
242 Sodium Borohydride 2205.39 3115.0 LOCAL
243 Sodium Chloride 6491.00 21997.0 LOCAL
244 Sodium dithionite 0 38.90 LOCAL
245 Sodium Hydroxide 15025.00 25042.0 LOCAL
246 Sodium Iodide 289.71 724.26 LOCAL
247 Sodium Methoxide (Solid) 26.12 272.3 LOCAL
248 Sodium Nitrite 32.45 967.55 LOCAL
249 Sodium Sulphite 69.62 3480.8 LOCAL
250 Sodium Thiosulphate Pentahydrate 0 61.9 LOCAL
251 Sodium Triacetoxy borohydride 0 520.8 LOCAL
252 Stannous Chloride Dihydrate 183.20 1831.98 LOCAL
253 Succinic acid 0 98 LOCAL
254 Sulphuric Acid - 97% 1579836 1510752.0 LOCAL
255 Tadalafil (TDL-I) 1000 INHOUSE
256 Tamsulosin Hydrochloride Stage-I 55.18 2758.8 INHOUSE
Tamsulosin Hydrochloride Stage-II For
257 seeding 0.32 16.2 INHOUSE
258 Tamsulosin Hydrochloride Stage-II 38.95 1947.4 INHOUSE
259 Tamsulosin Hydrochloride Stage-III 22.69 1134.50 INHOUSE
260 TEA 0 1770.5 LOCAL
261 Teneligliptin Hydrobromide Pure (TNL-II) 0 1.0 INHOUSE
262 Teneligliptin Hydrobromide Crude (TNL-I) 0 625 INHOUSE
263 Tert Butyl Chloride 195.10 4877.52 LOCAL
264 Terta Butyl Acrylate 15.85 792.37 LOCAL
265 Tertiary Butyl Alcohol 189.46 189.46 LOCAL
266 Tetrabutyl ammonium bromide 0 40.0 LOCAL
267 Tetra-Butyl Ammonium Hydrogen Sulphate 7.82 7.82 LOCAL
268 Tetrahydrofuran 350090.00 901659.00 LOCAL
269 TFC-I 0 1018.1 INHOUSE
270 Thebain 201.34 5033.56 LOCAL
271 Thebaine - Pure 185.23 4630.87 LOCAL
272 Thionyl Chloride 103.09 1639.30 LOCAL
273 Tizanidine Base Crude (TIZ-STAGE III) 112.99 452.0 INHOUSE
274 Tizanidine Base -Pure (TIZ-STAGE IV) 62.15 248.6 INHOUSE
275 Tizanidine Hydrochloride Stage-I 192.09 768.4 INHOUSE
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 42M/s. Unichem Laboratories Ltd. 276 Tizanidine Hydrochloride Stage-II 158.19 632.8 INHOUSE 277 TLT-I 207.86 831.4 INHOUSE 278 TLT-II 228.61 914.4 INHOUSE 279 TLT-III 175.39 701.5 INHOUSE 280 TNL Piperazine derivative 0 297.6 LOCAL 281 TNL Pyrrolidine derivative 0 386.9 LOCAL 282 Tofacitinib Citrate - II (TFC - II) 0 1131.2 INHOUSE 283 Tofacitinib citrate - III (TFC-III) 0 678.7 INHOUSE 284 Tofacitinib Citrate - IV (TFC-IV) 0 356.7 INHOUSE 285 Tofacitinib citrate - V (TFC- V) 0 588.2 INHOUSE 286 Toluene 84042 182665.0 LOCAL 287 Tributyl Amine 17.02 851.23 LOCAL 288 Triethylamine 15.85 2337.0 LOCAL 289 Trifluoroacetic Acid 15.39 769.73 LOCAL 290 Trimethyl Orthoformate 0 270.61 LOCAL 291 Triphenyl Phosphine 1.81 90.56 LOCAL 292 Triphosgene 0 781.2 LOCAL 293 TXS Stage-I(IDN 6116) 0 339.5 INHOUSE 294 TXS Stage-II (IDN 6007) 0 384.6 INHOUSE 295 TXS Stage-VI 0 261.6 INHOUSE 296 Vortioxetine hydrobromide Stage-I 0 1262.0 INHOUSE 297 Vortioxetine hydrobromide Stage-II 0 1009.6 INHOUSE 298 Vortioxetine hydrobromide Stage-III 0 833.3 INHOUSE M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 43
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Annexure IV-Plot layout
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Annexure V: valid CTO
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Annexure VI: CTO prior to 2006
M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 56M/s. Unichem Laboratories Ltd. M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 57
M/s. Unichem Laboratories Ltd. M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 58
M/s. Unichem Laboratories Ltd. M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 59
M/s. Unichem Laboratories Ltd. M/s. Sadekar Enviro Engineers Pvt. Ltd. Page 60
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