DELIVERING PANDEMIC RESILIENCE REVISITED - Bottlenecks to breakthroughs: What we've learned one year into COVID-19 and how we'll be ready for the ...

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DELIVERING PANDEMIC RESILIENCE REVISITED - Bottlenecks to breakthroughs: What we've learned one year into COVID-19 and how we'll be ready for the ...
CONFIDENTIAL

DELIVERING PANDEMIC
RESILIENCE REVISITED
Bottlenecks to breakthroughs: What we’ve learned
one year into COVID-19 and how we’ll be ready for
the next health emergency
DHL CSI – Customer Solutions and Innovation
DELIVERING PANDEMIC RESILIENCE REVISITED - Bottlenecks to breakthroughs: What we've learned one year into COVID-19 and how we'll be ready for the ...
CONFIDENTIAL

Revisiting Pandemic Resilience in a nutshell

          Out of the                                       It’s a marathon, not a   The home   Getting ready for
       starting blocks                                             sprint            stretch    the next race

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                              2
DELIVERING PANDEMIC RESILIENCE REVISITED - Bottlenecks to breakthroughs: What we've learned one year into COVID-19 and how we'll be ready for the ...
CONFIDENTIAL

CHAPTER 1: Out of the starting blocks

          Out of the                                       It’s a marathon, not a   The home   Getting ready for
       starting blocks                                             sprint            stretch    the next race

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                              3
CONFIDENTIAL

Although the last year was difficult, there are ten key achievements of the global community

                                                                                                                          Deep Dive on following slides

  1 COVID-19 vaccine                              2 Two new vaccine       3 Total global           4 The complex           5 Extreme
    development                                     platforms, that can     vaccine production       global vaccine          cold-chain
    occurred five times                             tackle diseases         quadrupled               supply chain was        requirements
    faster than any other                           beyond COVID-19,        within a year            ramped-up               were met at scale
    vaccine in history                              have emerged and                                 successfully            – flawlessly!
                                                    begun to mature

  6 The vaccination                               7 Multilateral action   8 Vaccine economics      9 Markets quickly      10 Large-scale
    rate already                                    was taken to            work: on a per           met the high            research on
    outpaces the                                    ensure global           capita basis end-to-     demand for              therapeutics
    infection rate by a                             access to               end costs for            testing, ancillary      has been
    factor of nine                                  vaccines                vaccination equal        supplies, and PPE       promising
                                                                            just one week of
                                                                            lockdown costs

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                                                                4
CONFIDENTIAL

  1 COVID-19 vaccine development occurred five times faster than any other vaccine in history

Vaccination innovation
Time from infectious agent identification to vaccine approval in the US, years

                       5x faster

        0.8        4                                                  10                                 16                                                   25               33       43
        COVID-19 Mumps
                1                                                    Measles                          Hepatitis B                                          Human           Diarrheal   Ebola
                                                                                                                                                        papillomavirus      disease

1: Note that COVID-19 vaccines have received Emergency Use Approval, whereas the other vaccines have received biologics license application approval in the stated time.
Source: Bernadeta Dadonaite, Max Roser, and Samantha Vanderslott, “Vaccination,” Our World in Data; “COVID-19 vaccines,” US Food and Drug Administration, fda.gov

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                                                                                                             5
CONFIDENTIAL

  3 Total global vaccine production quadrupled within a year

Vaccine production
2021, billion doses
                                                                                                                                                                                 20
                                                                                                                                                                                                                                              Pipeline
                                                                                                               5
                                                                                                                                                                                                                                              Authorized in at
                                                                                                                                                                                                                                              least 1 geography

                                                                                                                                                                                                                   4x

                                                                                                              10

                                            5

                                   Vaccines                                                     COVID-19 vaccines                                                              Total
                               before COVID-19

Source: UNICEF COVID -19 production tracker with additional assumptions on realization and shipment timing of announced volumes (per vaccine development stage). Pre-COVID-19 vaccine data based on Airfinity and the WHO Global Vaccine Market Report 2020.

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                                                                                                                                                                                     6
CONFIDENTIAL

 4 The complex global vaccine supply chain was ramped-up successfully

DPDHL is the trusted partner for Covid-19 vaccine logistics worldwide                            Key contributions to date

                                                               End-to-end
                                                                            Controlled           >338 million doses distributed internationally
                   All related                                 solutions
                                                                            temperature
                    products
                                                                                                 >140 countries served
        All approved
             vaccines                                                               Real-time    >9,000 flights operated to deliver vaccines
                                                                                    tracking

                                                                                                 >350 DHL facilities involved in the process
          All
   continents                                                                         Highest
                                                                                      security   >50 collaborations in the pharma & public sector

                                                                                                 >10 new and dedicated services introduced

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                                                            7
CONFIDENTIAL

  6 The vaccination rate already outpaces the infection rate by a factor of nine

Covid-19 vaccination vs. cases
Million people

     700
                                                                                                                                People who have received
     600                                                                                                                        at least 1 dose

     500                                                                                                                        +550
                                                                                                                                since Jan 2021
     400

     300

     200                                                                                                                        Total COVID-19 cases

     100                                                                                                                        +65
                                                                                                                                since Jan 2021
          0
           Mar             Apr            May            Jun     Jul   Aug   Sep   Oct   Nov   Dec   Jan   Feb   Mar    Apr   May

                                                                   2020                                          2021
Source: Our World in Data COVID-19 data explorer, Apr 28, 2021

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                                                                     8
CONFIDENTIAL

    Vaccine economics work: on a per capita basis end-to-end costs for
  8 vaccination equal just one week of lockdown costs

COST PER PERSON
EUR

                                                                                   ~300 - 500

                                                                                                                                                                        E2E logistics represent
                                                                                                            ~3-8x
CONFIDENTIAL

CHAPTER 2: It’s a marathon, not a sprint

          Out of the                                       It’s a marathon, not a   The home   Getting ready for
       starting blocks                                             sprint            stretch    the next race

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                         10
CONFIDENTIAL

Only a small fraction of vaccination rollout achieved – upcoming phase will be challenging

With 1 of 10 bn of the required doses                                                                                        … and the rollout to 220 countries pose
administered, …                                                    … a concentrated production footprint                     challenges for logistics
  bn vaccine doses                                                                                                               Number of countries clustered by the share of
                                                                                                                                 people fully vaccinated
                                                           10

                                                                                                                                  >50%         4

                                                                                            95%        of

                                       x10                                                 global vaccine
                                                                                            production is                         10-50%           28
                                                                                          concentrated in 8
                                                                                             countries*

                      1
                                                                                                              5% in the
CONFIDENTIAL

10 building blocks to go from 4 to 220 countries with
successful vaccination campaigns

                                                                                1   Partnerships without borders
                                                               Fostering
                                                               collaboration
                                                                                2   Supportive data backbone

                                                               Securing         3   Transportation capacity management
                                                               inbound
                                                               flows            4   Packaging sustainability

                                                                                5   Strategic warehousing
                                                               Setting up the
                                                               last mile for    6   Synchronized flow of goods
                                                               success
                                                                                7   Vaccination points

                                                                                8   Well-informed population
                                                               Maximizing
                                                               demand for       9   A User-Friendly Process
                                                               vaccines
                                                                                10 Incentives convincing last movers

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                               12
CONFIDENTIAL

CHAPTER 3: The home stretch

          Out of the                                       It’s a marathon, not a   The home   Getting ready for
       starting blocks                                             sprint            stretch    the next race

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                         13
CONFIDENTIAL

Going forward, 7-9 bn additional doses will be needed annually to keep COVID-19 in check

Estimated additional vaccine quantities for 2022 and beyond                                                                        The need for an additional 7-9 billion doses
Billions                                                                                                                           will be driven by three factors:

                                                                                                                                     4-5 billion doses will account for ”booster shots”
                                                                                                                                     to maintain the immunity of people who were
 Booster shots                                                                                      ~4-5                             vaccinated in 2021.

 Patients in                                                                                                                         Another 2-3 billion doses will be earmarked for
                                                                                                                     ~2-3            patient groups, such as children under the age of
 new groups
                                                                                                                                     12, who will likely be eligible after the
                                                                                                                                     conclusion of ongoing clinical trials.

 New patients                                                                                                               ~1
                                                                                                                                     With time willingness to get vaccinated will
                                                                                                                                     likely increase, these new patients will account
                                                                                                                                     for an additional ~1 billion doses (assuming a 10-
 Total                                                                                                                      ~7-9     percentage point uptake).

Source: UN Department of Economic and Social Affairs; Johns Hopkins Center for Communication Program; DHL analysis

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                                                                                               14
CONFIDENTIAL

3 watchouts needed to be implemented to ensure that today’s supply chain
provides a solid platform for the next years

Players need to implement 3 measures:                                                                                … then supply chain provides solid platform due to 30% lower volume

                                                                                                                     Projected global vaccine shipping volumes
                             Remain prepared for high patient                                                        Billion doses
                             and vaccine volumes
                                                                                                                                                ~15-20

                                                                                                                                                                 ~12-14        ~12-14
                             Maintain logistics infrastructure
                             and capacity                                                                                                       ~10-15
                                                                                                                                                                  ~7-9          ~7-9

                                                                                                                               5

                             Plan for seasonal fluctuations

                                                                                                                             2020                 21              22            2023

Source: UNICEF COVID -19 production tracker, Airfinity and the WHO Global Vaccine Market Report 2020. DHL analysis

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                                                                                                      15
CONFIDENTIAL

CHAPTER 4: Getting ready for the next race

          Out of the                                       It’s a marathon, not a   The home   Getting ready for
       starting blocks                                             sprint            stretch    the next race

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                         16
CONFIDENTIAL

Getting ready for the next race: 10 strategic actions governments and other
stakeholders should consider pursuing now

Prevention and early identification                            Containment and countermeasures           Medication rollout capacity

     1 Institutionalize active partnerships                     5 Implement national containment and       8 Maintain “ever-warm” manufacturing
       and systems                                                escalation plans                           capacity

     2 Double down on global early-warning                      6 Leverage digital contact tracing and     9 Define blueprint research, production,
       systems                                                    monitoring app                             and procurement plan for diagnostics,
                                                                                                             therapeutics, and vaccines
     3 Create and follow through on                             7 Establish an emergency stockpile and
       integrated epidemic-prevention                             associated “supplies and logistics”      10 Maintain and expand rollout
       agenda                                                     emergency system                            capabilities for diagnostics,
                                                                                                              therapeutics, and vaccines
     4 Invest in targeted research and
       development to improve diagnostics,
       therapeutics, and vaccines

DHL CSI – Customer Solutions & Innovation | Bonn | June 2021                                                                                            17
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