Wound Recuperation and Approaches of Aloe Barbadensis for Traumatize Mending: A Review
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
Journal of Survey in Fisheries Sciences 10(4S) 128-134 2023
Wound Recuperation and Approaches of Aloe
Barbadensis for Traumatize Mending: A
Review
Hansraj Bishnoi1*, Shailesh Sharma2, Garvendra Singh Rathore3 Omveer Singh4
1
Research Scholar, Department of Pharmacy, Dr. K.N. Modi University, Newai, Tonk,304021,
Rajasthan, India
2
Department of Pharmacy, Shyam University, Dausa, 303511, India.
3
Lal Bahadur Shastri College of Pharmacy, Jaipur, Rajasthan, India.
4
MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be university), Mullana-133207,
Ambala, India.
Email: 1hansbishnoi29@gmail.com
2
dr.shailus@gmail.com
3
garvendra@gmail.com
4
omveerpharmd123@gmail.com
Abstract
The most widely used medical plant in the world is aloe vera, the oldest known medicinal plant. Lotion is made
in several steps, including cutting the tip and base of the leaf, extracting the mucilage portion, grinding it
thoroughly, adding vitamin E, pasteurising the mixture, and cooling it. After the gel is made, it is measured out
and mixed with other ingredients, including the gel, to make the lotion. With a pH of 5.5 and great extrudability,
the formulation is greenish in hue. There were no negative effects from the natural remedy. This herbal remedy
has been shown to be effective in treating inflammation, wounds, tumors, ageing, and other conditions.
Keywords: Herbal formulation, aloe vera, herbal lotion, herbal gel, wound mending
1. INTRODUCTION: - "the blessing"[9]. Aloe was a formerly
Aloe is also prevalent in both conventional thought to belong to the Liliaceae family,
and Ayurvedic and Chinese medicine. but it has it has been assigned to the
Aloe vera is referred to as originated from Aloaceae family. Aloe vera has a positive
the Arabic term "Aloe," which means impact on human health and can treat
While "vera" in Latin means "shining various diseases.
bitter material," “true” [1-12]. The history 1.1 Plant details: Its habitat is primarily
of the plant Aloe vera dates back era of the moist Africa, Asia, Europe, and America's
Bible. There are more than 250 varieties of arid regions. It exists in Rajasthan, Andhra
aloe. globally cultivated Two species only Pradesh, and Tamil Nadu, Gujarat, and
are raised for use in commerce: Aloe Maharashtra [12]. Geographic Source:
barbadense Miller and Aloe arborescent. South America is the native home of aloes
Numerous people have knowledge about South America and Africa, but they are
this plant monikers like "the wand of currently cultivated excluding the tundra,
heaven," "heaven's" The silent healer" and deserts, and rain forests, everywhere. It
128Wound Recuperation and Approaches of Aloe Barbadensis for Traumatize Mending: A Review
reaches maturity in four years on average The present Anthraquinones, chromones,
and has an average lifespan of 12 years and other compounds are found in aloe
[10]. an active part of the three layers of a include enzymes and polysaccharides.
plant's leaves. The highest strata or formed Those substances Al, B, Ba, Ca, Fe, Mg,
of a layer of defense 15–20 cells thick Na, P, Si, and other substances have
protein and carbohydrate synthesis [15]. reportedly also Present.
Figure 1: Composition of Biomolecules
It is successfully developed by cultivation skin more elastic less wrinkly, has an anti-
in low-fertility marginal to sub-marginal inflammatory effect, and is restrained
soils The Plants tend to withstand high pH Candida albicans' development, laxatives,
and high Na levels. K salts, too. The earth and Effects: Aloe vera latex has laxative
shouldn't be too deeply disturbed, since properties that can be abused constipation,
Aloe's root system only descends 20–30 but it's also a purgative. Aloe vera extract's
feet. It is spread through rhizome cuttings anti-bacterial properties were7 out of the
or root suckers. Aloe may be grown 12 species of organisms are bactericidal.
successfully in both irrigated and non- Aloe vera, a powerful immune booster, has
irrigated with the presence of rain. been shown to the T cells and
supplying irrigation Aloe's Biological and macrophages in the white blood cells, The
Pharmacological Activity Aloe vera has a aloe plant has antioxidant and antitumor
72% chance of preventing adjuvant properties.
arthritis and result in a 22–26% regression
at a dosage of 150mg/kg daily. It could 2. MATERIAL AND METHOD
lessen edema, as we discovered.80%. Experimental Work Equipment: - Digital
maintaining wound moisture and boosting balance, pH meter, measuring cylinder,
epithelial cell improvement in skin glass bowl, spoon, Brooke filed
hydration and a decrease in irritation Aloe viscometer.
has great anti-aging effects and makes the Required Material
129Journal of Survey in Fisheries Sciences 10(4S) 128-134 2023
Table-1: Materials of formulation
2.1 Getting ready for formulation: - 2.2.3 Homogenization and grinding are the
Clean and Clean up the area where you two main phases in this Crushing and
work and all your packaging supplies. It is grinding are processes. Aloe vera gel Use
advised that you put on gloves and safety a to smash and homogenies the fillets at-
gear. While cooking this meal, and a hair room commercial high-speed tissue
net. Collect raw material (aloe leaves) crusher (25 °C) and include agar-agar into
Washing leaf and removed base and tip of the mixture.
the leaf, leaf is cut into section (Filleting) 2.2.4 Vitamin E addition - Unpasteurized
Extract mucilage part of the leaves into aloe gel vitamin E was added to juice to
mixing jar and heat it and add agar-agar enhance the Aloe vera juice taste and to
into the mixing jar. keep the juice. Due to its antioxidant
Grinding/Homogenization of properties, it is used.
Unpasteurized Juice Add Vitamin E and 2.2.5 Pasteurization- Treatment (1–2
Pasteurize the mixer cool the mixer of aloe minutes at 85–95 °C) is a practical way to
leaf Packaged the produced gel and stored avoid the unpleasant flavor and the Aloe
it. vera gel's loss of biological activity.
2.2 Steps Used in Formulation of Gel After pasteurization, the juice is flash
2.2.1 Raw materials reception: Aloe vera cooled within 10-15 seconds, the
leaf harvesting, it was preferable to carry temperature dropped to 5°C or lower. Here
the processing facility The leaves ought to is an essential action to keep the biological
be healthy intact, root and mold-free, and function of the Aloe vera lotion.
ripened (3–4 years) in keeping all the 2.2.6 Storage: Two factors are temperature
active components completely intact and relative humidity the most significant
concentration. environmental factors that affect the
2.2.2 Filleting procedure: It was proved product's quality.
that the aloe gel, being removed from the 2.2.7 Lotion formulation technique:
leaf, was more stable unlike the gel still Measure the quantity of the gel already
inside the leaf. To stay away from the created. Consider each other substance
biological activity's breakdown, the Within used in the composition. Grab a big glass
36 hours, the filleting operation must be or plastic dish for mixing. Add the
finished of collecting leaves. measured-out gel into the mixing basin
with the aloe vera. adding added one by
130Wound Recuperation and Approaches of Aloe Barbadensis for Traumatize Mending: A Review
one, ingredient by ingredient, in the epidermis. Rating: somewhat sluggish,
formulation vitamin E, glycerin, coconut rapid.
oil, rosewater, and essential oils oil and Consistency and gregariousness were both
arrowroot powder in the proper amounts present application to the skin and
aggressively combine all the bowl's checking.
ingredients manner. The herbal lotion was All aloe vera compositions have a uniform
made. appearance. They were a pale green
colour. When the product was applied by
3. EVALUATION PARAMETER hand, it was washable noticed in a flowing
Spread ability is the word used to describe body of water.
the size of the territory where a 3.1.3. Irritability Test: Left hand was
formulation can spread easily when treated with cream.1 square centimeter-
applied to the skin or other affected area. sized dorsal side surface, seen in equal
The mending the spreading of a periods of up to 24 hours for irritancy,
formulation affects its effectiveness as redness and edema. The did not produce
well value [16], [29]. any irritation or redness on skin.
The following formula is used to compute 3.2. Body application:
it: Drinking Aloe Vera juice aids in digestion
S = M. L / T where M is the weight stimulates bowel movement and aids in if
attached to the top slide a person is constipated, elimination. Also,
L = the length of the glass slides. if you get diarrhea, it will go more slowly.
T is the duration it took to separate the Stimulates the immune system: Aloe vera
slides. pH measurement- pH of a 1% juice the white blood cells known as
aqueous solution of a calibrated device macrophages that battle viruses.
was used to measure the formulation Aloe vera juice is a fantastic natural
constant temperature digital pH meter pH remedy for detox. Aloe vera juice can help
level is 5.5 for the formulation. within credibly nutritious mixture of
Homogeneity was examined in all gels that vitamins, minerals, and to aid our bodies
had been created. Upon setting the gels in cope with this, trace elements daily
the container, homogeneity can be checked demands and stresses.
visually. They had evaluations for 3.3. Application in practice
presence and appearance of any aggerates. Researchers evaluated a gel for aphthous
Measurement of a substance's viscosity ulcer combine silicon dioxide, Aloe vera,
Using a Brookfield viscometer, the and all antibiotics as well as how it affects
produced gel was evaluated. Spindle oral aphthous ulcers [9]. [30].
number 7 and a speed of 25 rpm. C. 3.3.1. Oral Lichen Planus: Aloe Vera's
3.1.1 Smoothness: The lotion's level of effectiveness in Efficacy of oral lichen
smoothness Testing the formulation plan us treatment as decided by many
involved rubbing between the using academics [9].
fingers, check the gel's smoothness 3.3.2. Gingivitis: Several research projects
clumped, uniform, or rough have been conducted to decide whether
3.1.2. Absorbency- The rating at which a aloe vera works to treat gingivitis.[9].
product is thought to be taken up by the 3.3.3. Denture adhesive- This is a
skin. decided by seeing changes in the characteristic that caused the prototype
131Journal of Survey in Fisheries Sciences 10(4S) 128-134 2023
acemannan denture manufacture characteristics of such as the spread ability
adhesives. and pourability of the formulation product.
3.3.4. Cancer: Polysaccharides and glycol The spread ability statistics show that the
proteins are present make Aloe vera a gel easily spreadable with a light shear.
powerful chemo-preventive in agent The Assessment of Extrudability assumes
effective against a variety of cancer kinds. significance criterion. Each Gel
These substances energies the immune composition had a fantastic extrudability.
system to combat opposed to cancer. The three people who were evaluated for
Aloe vera gel works well as an effective stability months, and the outcomes showed
anti-hypertensive medication for type 2 that all the gels displayed improved
diabetes. It reduces blood glucose without stability The stability investigation did not
interfering the typical liver/kidney find any many changes in viscosity after
function and blood lipid level’s function. testing at various thermal circumstances.
3.3.5. Asthma: Aloe vera extract should be The formulation was dependable under
kept in the dark for Three to ten days yield typical storage circumstances. These
some active proteinoids are compounds. outcomes showed that the topical drug was
These active ingredients have proved not adversely affected by the herbal gel
success in treating persistent bronchial area. This herbal remedy has been shown
asthmatics. to be helpful in results and discussion on
Applications for aloe vera in cosmetics: inflammation, wound mending, and anti-
gel and powder have many other aging the aloe vera plant may be used in
applications in the cosmetic industry due medicine, cosmetic and dietary industries.
to their valuable moisturizing and soothing The preparation of Aloe vera needs urgent
effects in products like shampoos, soaps, care in terms of timing and temperature
cleansers and moisturizing creams. Soaps sanitary conditions. The body lotion and
prepared with Aloe vera have the herbal gel produced, then put up for
advantage that they do not cause irritation examination by several parameters.
and do not leave this kindly [31].
5. CONCLUSION
4. RESPONSE AND CONVERSATION The aloe vera plant can be utilised in the
The aloe vera plant may be used in food, cosmetic, and medical fields.
medicine cosmetic and dietary industries. Regarding timing, temperature, and
The preparation of Aloe vera needs urgent hygienic conditions, aloe vera preparation
care in terms of timing and temperature demands immediate attention. The body
sanitary conditions. The body lotion and lotion and herbal gel were made, and
herbal gel produced, then put up for numerous metrics were used to evaluate
examination by several parameters. The them. The herbal treatment was coloured
herbal remedy had a greenish tint color. with a greenish tint. The usage of the gel
From the beginning of the investigation to did not irritate the skin at any point during
about the pH of the skin and the body is the inquiry, and the pH of the skin and the
normally between 5.5 and 7.2. use of the body is typically between 5.5 and 7.2. The
gel did not cause any irritation to the skin. most crucial factor in the evaluation is
Viscosity is the most important parameter viscosity because it regulates a number of
in the evaluation, as it controls many properties, including the spreadability and
132Wound Recuperation and Approaches of Aloe Barbadensis for Traumatize Mending: A Review
pourability of the formulation product. The Cosmetic Use of Aloe Vera – A
aloe vera plant can be utilised in the food, Review. 2014;3(5):342-458.
cosmetic, and medical fields. [11] Bal A, Tara, Deva A S, Madan J,
Sharma S. Preparation and Evaluation
REFERENCES of Novel Aloe Vera Gel Beads.
[1] Atlaw T K. Preparation and 2013;2(6):206-216.
Utilization of Natural Aloe Vera to [12] Itrat M, Zarnigar. Aloe Vera: A
Enhance Quality of Mango Fruit. Review of Its Clinical Effectiveness.
2018;6(3):76-81. 2013;4(8):75-79.
[2] Maana A A, Nazir A, Khan M K I, [13] Scala K D, AntonioVegagálve Z,
Ahmad T, Zia R, Murid M, Abrar M. Ahen K, Nuñez-Mancilla Y,
The Therapeutic Properties and Munizaga G T, Pérez-Won M,
Applications of Aloe Vera: A Review. Giovagnoli C. Chemical and Physical
2018:1-10. Properties of Aloe Vera (Aloe
[3] Yohannes G. Review on Medicinal Barbadensis Miller) Gel Stored After
Value of Aloe Vera in Veterinary High Hydrostatic Pressure Processing.
Practice. 2018:01-06. 2013:52-59.
[4] Mendhekar S Y, Thorat P B, Bodke N [14] Chandegara V, Varshney A K.
N, Jadhav SL, Gaikwadd D. Aloe Vera L. Processing and Product:
Formulation and Evaluation of Gel A Review. 2013;3(4):492-506. 15.
Containing Neem, Turmeric, Aloe Sahu P K, Giri D D, Singh R, Pandey
Vera, Green Tea and Lemon Extract P, Gupta S, Shrivastava A K, Kumar
with Activated Charcoal and Honey. A, Pandey K D. Therapeutic and
2017;12(4):439-443.ISSN 394-3211. Medicinal Uses of Aloe Vera: A
[5] Pardeshi M D. Formulationand Review. 2013; 4:599-610.
Evaluation of Aloe-Vera Gel with [15] Singh M, Nagori B, Shaw N,
Active Salt and Alum: As A New Tiwari M, Hanwar B. Formulation
Dentifrice. 2016;6(5):297-310. Development & Evaluation of Topical
[6] Pandey A, Singh S. Aloe Vera: A Gel Formulations Using Different
Systematic Review of Its Industrial Gelling Agents and Its Comparison
and Ethno-Medicinal with Marketed Gel Formulation.
Efficacy.2016;5(1):21-33. 2013;3(3):1-10.
[7] Nia A F, Farhangsardrodi A. [16] Rajeswari R, Umadevi M, Rahale
Morphological &Physiologocal S, Pushpa R, Selvavenkadesh, Kumar
Changes of Aloe (Aloe Barbadensis K S, Bhowmik D. Aloe Vera: The
Miller) In Response to Culture Media. Miracle Plant Its Medicinal and
2015;6(6):100-105. Traditional Uses in India. 2012;
[8] Bhuvana, Hema, Patil R T. Review on 1:118-124.
Aloe Vera.2014;2(3):677-691. [17] Maqbool S, Jairajpuri D, Bashir K.
[9] Sajjad A, Sajjad SS. Aloe Vera: An Preparation and Processing of Orange
Ancient Herb for Modern dentistry-A FlavouredAloevera Gel. 2012;1(5):40-
Literature Review. 2014:01-06. 43.
[10] Periasamy, Kassa P, Sintayehu B, [18] Pounikar Y, Jain P, Khurana N,
Libanos M, Gereziher G, Karim A. Omray K, Patil S, Gajbhiye A.
133Journal of Survey in Fisheries Sciences 10(4S) 128-134 2023
Formulation and Characterization of 03(Ii), July - September, 2022, Pp. 26-
Aloe Vera Cosmetic Herbal Hydrogel. 32
2012; 4:85-86. [27] Shailesh Sharma, A. Mittal, Sonu
[19] Khan A, Khan M, Iqbal, Bashir. S, Raj Kumari, Wagh Jyoti
Formulation Development and Preparation and evaluation of
Moiturising Effects of a Topical modified herbal “Kumkum Powder”
Cream of Aloe Vera Extract. to reduce allergic reactions,
2011;5(3):128-136. International Journal of Health
[20] Ahlawat K S, Khatkar B S. Science 6 (S5), 11274-11283on
Processing, Food Applications and 14/10/2022.
Safety of Aloe Vera Products: A [28] Manohar Chouhan , Sandeep
Review. 2011;48(5):525–533. Rathor , Vishal Garg , Ambika
[21] Yagbemi TI, Azeez O. Assessment Sharma , Pritam Singh , Jay Chandra ,
of Chronic Administration of Aloe Vikram Kumar , Sanavi Byahut ,
Vera Gel onHaematology, Plasma Omveer Singh. Enhancement Of
Biochemistry, Lipid Profiles and Solubility And Dissolution
Erythrocyte Osmotic Resistance in Characteristics Of Etoricoxib By Solid
Wistar Rats. 2010:107-113. Dispersion Technique Using Different
[22] Tambe R, Kulkarni M, Joice A, Grade Of Peg Carrier Using. Journal
Gilani I. Formulation and Evaluation Of Pharmaceutical Negative Results
of Aloe Vera Gels. 2009;2(10):1588- [Internet]. 2023 Feb. 8 [Cited 2023
1590. Feb. 26];:3233-42. Available From:
[23] Hamman J. Composition and Https://Www.Pnrjournal.Com/Index.P
Applications of Aloe Vera Leaf hp/Home/Article/View/8263
Gel.2008:1599-1616. [29] Nisha, Omveer Singh , Sandeep
[24] Ramachandra C, Rao S. Processing Rathor , Sadia Parveen , Soma Ghosh
of Aloe Vera Leaf Gel: A Review. , Shailesh Sharma , Hina Sharma ,
2008;3(2): Page 502-510 Nitish Gaur. Desloratadine: An Insight
[25] Shreyasi, Shailesh Sharma, Hansraj on Acute Inflammation. Journal of
Bishnoi And Manmohan Sharma. Pharmaceutical Negative Results
Formulation And Evaluation Of [Internet]. 2023 Jan. 1 [cited 2023
Herbal Lotion For Antimicrobial Feb. 26];:590-8. Available from:
Activity, World Journal Of Pharmacy https://www.pnrjournal.com/index.ph
And Pharmaceutical Sciences, p/home/article/view/7249
Volume 11, Issue 5, 1907-1913. [30] Mahbubur Rahman, Omveer Singh
[26] Hansraj Bishnoi, Shailesh Sharma et al., A Review on Psoriasis,
Et.Al. A Review On Moringa Olifera NeuroQuantology, 2022: 20 , 16,
Based On Chemical Composition And 5786-5793.
Wound Healing Activities,
International Journal Of Education,
Modern Management, Applied
Science & Social Science (Ijemmasss)
26 Issn: 2581-9925, Volume 04, No.
134You can also read
