Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...

Page created by Matthew Cummings
 
CONTINUE READING
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
www.hkmacme.org January 2019

B      U      L    L   E   T   I   N

Short Notes on MRI –
MRI of the adult spine
Dr. KWOK Kai Yan

                                                             CME
                                                             LIVE
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
HKMA CME Bulletin

Contents
Editorial 1
Spotlight 2
    Short Notes on MRI - MRI of the
    adult spine
Cardiology          5
    A 54 year old lady with heart
    murmur
Dermatology             7
    A girl with rough nails for one year                    Spotlight
Answer Sheet 11                                             Short Notes on MRI -
CME Notifications 14                                        MRI of the adult spine
Meeting Highlights 17
CME Calendar 18

HKMA CME Bulletin – MONTHLY SELF-STUDY
SERIES to help you grow!
Please read the following articles and answer the
questions. Participants in the HKMA CME Programme
will be awarded credit points under the Programme
for returning the completed answer sheet via fax
(2865 0943) or by mail to the HKMA Secretariat on
or before 15 February 2019. Answers to questions
will be provided in the next issue of the HKMA CME
Bulletin. (Questions may also be answered online at      The Hong Kong Medical Association is dedicated to providing a coordinated CME
www.hkmacme.org)                                         programme for all members of the medical profession. Under the HKMA CME
                                                         Programme, a CME registration process has been created to document the CME
                                                         efforts of doctors and to provide special CME avenues. The Association strives to
                                                         foster a vibrant environment of CME throughout the medical profession. Both members
                                                         as well as non-members of the Association are welcome to join us. You may contact
                                                         the HKMA Secretariat for details of the programme.

       HKMA CME Enquiry Hotline
             Tel: 2527 8452
Address: 5/F, Duke of Windsor Social Service Building,
         15 Hennessy Road, Hong Kong                             Advertising Enquiry: 2527 8452   Fax: 2865 0943/Email: cme@hkma.org
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
CME Bulletin & Online Editorial Board
                                                                                                                              EDITORIAL
Chief Editor
Dr. LAM Ho
Dr. WONG Bun Lap, Bernard

Executive Committee
Dr. CHAN Yee Shing, Alvin                                                                                                     Dearest HKMA Fellow Colleagues
Dr. CHENG Chi Man
Dr. CHEUNG Hon Ming
                                                                                                                              Happy new year 2019’
Dr. CHOI Kin
Dr. HO Chung Ping, MH, JP
                                                                                                                              In this very happy beginning of our new year 2019’
Dr. HO Hung Kwong, Duncan                                                                                                     please kindly let me share with you my collection on
Dr. LAM Tzit Yuen, David
Dr. LI Sum Wo, MH                                                                                                             words of wisdom about new year.
Dr. TSE Hung Hing, JP
Dr. WONG Bun Lap, Bernard
                                                                                                                              “Write it on your heart that every day is the best day of the year.”
                                                                                                                              ~ Ralph Waldo Emerson (1803-1882), American essayist,
Cardiology                                                     Neurology
Dr. CHEN Wai Hong                                              Dr. FONG Chung Yan, Gardian                                      lecturer, philosopher and poet
Dr. HO Hung Kwong, Duncan                                      Dr. TSANG Kin Lun, Alan
Dr. LEE Pui Yin
Dr. LI Siu Lung, Steven                                        Neurosurgery
                                                                                                                              “Cheers to a new year and another chance for us to get it right”
Dr. WONG Bun Lap, Bernard                                      Dr. CHAN Ping Hon, Johnny                                      ~ Oprah Winfrey (1954-), American media executive, actress,
Dr. WONG Shou Pang, Alexander                                                                                                   talk show host, television producer and philanthropist
Dr. WONG Wai Lun, Warren                                       Obstetrics and Gynaecology
                                                               Dr. CHAN Kit Sheung
Cardiothoracic Surgery                                                                                                        “Be at war with your vices, at peace with your neighbors, and let
Dr. CHENG Lik Cheung                                           Ophthalmology
Dr. CHIU Shui Wah, Clement                                     Dr. LIANG Chan Chung, Benedict                                 every new year find you a better man.”
Dr. CHUI Wing Hung                                             Dr. PONG Chiu Fai, Jeffrey                                     ~ Benjamin Franklin (1705-1790), American polymath, one of
Dr. LEUNG Siu Man, John
                                                               Orthopaedics and Traumatology
                                                                                                                                the Founding Fathers of United States, leading author, printer,
Colorectal Surgery                                             Dr. IP Wing Yuk, Josephine                                       political theorist, politician, freemason, postmaster, scientist,
Dr. CHAN Cheung Wah                                            Dr. KONG Kam Fu                                                  inventor, humorist, civic activist, statesman and diplomat.
Dr. LEE Yee Man                                                Dr. POON Tak Lun
Dr. TSE Tak Yin, Cyrus                                         Dr. TANG Yiu Kai
                                                                                                                              “Come, gentleman, I hope we shall drink down all unkindness.”
Dermatology                                                    Paediatrics
Dr. CHAN Hau Ngai, Kingsley                                    Dr. CHAN Yee Shing, Alvin                                      ~ William Shakespeare (1564-1616), English poet, playwright
Dr. HAU Kwun Cheung                                            Dr. FUNG Yee Leung, Wilson                                       and actor, greatest writer in the English language and the
                                                               Dr. TSE Hung Hing, JP
Endocrinology                                                  Dr. YEUNG Chiu Fat, Henry
                                                                                                                                world’s greatest dramatist
Dr. LEE Ka Kui
Dr. LO Kwok Wing, Matthew                                      Plastic Surgeon                                                “At a dinner party one should eat wisely but not too well, and talk
                                                               Dr. NG Wai Man, Raymond
ENT                                                                                                                           well but not too wisely.”
Dr. CHOW Chun Kuen                                             Psychiatry                                                     ~ W Somerset Maugham (1874-1965), British playwright,
                                                               Dr. LAI Tai Sum, Tony
Family Medicine                                                Dr. LEUNG Wai Ching                                              novelist and short story writer, most popular writers of his era
Dr. LAM King Hei, Stanley                                      Dr. WONG Yee Him, John                                           and the highest-paid author during the 1930s.
Dr. LI Kwok Tung, Donald, SBS, JP
                                                               Radiology
Gastroenterologist                                             Dr. CHAN Ka Fat, John                                          “Going to a party, for me, is as much a learning experience as,
Dr. NG Fook Hong                                               Dr. CHAN Yip Fai, Ivan                                         you know, sitting in a lecture.
General Practice                                               Respiratory Medicine                                           ~ Natalie Portman (1981-), Israeli-American film actress,
Dr. YAM Chun Yin                                               Dr. LEUNG Chi Chiu                                               producer, and director
                                                               Dr. WONG Ka Chun
General Surgery                                                Dr. YUNG Wai Ming, Miranda
Dr. LAM Tzit Yuen, David                                                                                                      “All of us every single year, we’re a different person. I don’t think
Dr. LEUNG Ka Lau                                               Rheumatology
                                                               Dr. CHAN Tak Hin
                                                                                                                              we’re the same person all our lives.
Geriatric Medicine                                             Dr. CHEUNG Tak Cheong                                          ~ Steven Spielberg KBE OMRI (1946-) American Filmmaker,
Dr. KONG Ming Hei, Bernard                                                                                                      highest-grossing film director in history, one of the founding
Dr. SHEA Tat Ming, Paul                                        Urology
                                                               Dr. CHEUNG Man Chiu                                              pioneers of the New Hollywood era and one of the most
Haematology                                                    Dr. KWOK Ka Ki                                                   popular directors and producers in film history.
Dr. AU Wing Yan                                                Dr. KWOK Tin Fook
Dr. MAK Yiu Kwong, Vincent
                                                               Vascular Surgery                                               “Your success and happiness lies in you. Resolve to keep
Hepatobiliary Surgery                                          Dr. TSE Cheuk Wa, Chad
Dr. CHIK Hsia Ying, Barbara                                    Dr. YIEN Ling Chu, Reny
                                                                                                                              happy, and your joy and you shall form an invincible host against
Dr. LIU Chi Leung                                                                                                             difficulties.”
                                                               HKMA Secretariat                                               ~ Helen Keller (1880-1968), American author, political activist,
Medical Oncology                                               Ms. Jovi LAM
Dr. TSANG Wing Hang, Janice                                    Miss Irene GOT                                                   and lecturer, the first deaf-blind person to earn a bachelor of
                                                               Miss Ivy IP                                                      arts degree.
Nephrology
Dr. CHAN Man Kam
Dr. HO Chung Ping, MH, JP
Dr. HO Kai Leung, Kelvin
                                                                                                                              The HKMA CME Bulletin Editorial Board and CME
                                                                                                                              Committee wish you all a prosperous, healthy and
NOTICE
                                                                                                                              happy new year 2019’
Medical knowledge is constantly changing. Standard safety precautions must be followed, but as new research
and clinical experience broaden our knowledge, changes in treatment and drug therapy may become necessary
or appropriate. Readers are advised to check the most current product information provided by the manufacturer                Dr. WONG Bun Lap, Bernard
of each drug to be administered to verify the recommended dose, the method and duration of administration, and
contraindications. It is the responsibility of the practitioner, relying on experience and knowledge of the patient, to       Chief Editor
determine dosages and best treatment for each individual patient. Neither the Publisher nor the Authors assume any
liability for any injury and/or damage to persons or property arising from this publication.                                  Hong Kong Medical Association CME Bulletin
Although all advertising material is expected to conform to ethical (medical) standards, inclusion in this publication does
not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its
manufacturer.
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
SPOTlight

    Short Notes on MRI –                                                                      Dr. KWOK Kai Yan
    MRI of the adult spine                                                                    MBChB (CUHK), FRCR, FHKCR, FHKAM
                                                                                              (Radiology), Dip Med (CUHK), PDipCAH (HK)
                                                                                              Specialist in Radiology

                                                                         for incidental lesions in the regions not originally planned to
     Introduction                                                        be investigated. Although there is similar practice about the
                                                                         sagittal scanning ranges for each region of the spine, the
    Magnetic Resonance Imaging (MRI) of the spine is one of the          coverage by axial images can vary for the same region of
    most commonly performed MRI examinations. In this short              the spine in different patients. The axial imaging may span all
    article, I would share some technical issues which may be            levels of the included sagittal scanning range, or cover the
    useful for clinicians when adult patients are referred for MRI of    levels of clinical interest, or cover the levels where abnormality
    the spine.                                                           is detected on imaging. The acquisition of axial images is
                                                                         often the most time-consuming component during MRI of the
     Indications for MRI of the spine                                    spine. Depending on clinical indications and imaging findings,
                                                                         radiologists may decide to focus on certain spinal levels to
    MRI provides excellent soft tissue contrast. Concerning the          improve the image quality (e.g. by adjusting the slice thickness
    imaging of spine, it is the only radiological investigation that     and inter-slice gaps etc.) for better assessment while skip
    allows non-invasive evaluation of the internal anatomical            certain spinal levels to control the overall imaging time.
    structure of spinal cord. MRI is superior in assessing the spinal
    cord, nerve roots, intervertebral discs, bone marrow and other
    soft tissue structures along the spine when compared with
    other imaging modalities. It also lacks radiation and is the ideal
    imaging method for conditions that require repeated follow up.

    Indications for MRI of the spine are numerous, including
    neoplastic, infective, inflammatory, autoimmune, traumatic,
    vascular, degenerative, congenital and many other
    miscellaneous conditions. In daily practice, majority of patients
    would have already undergone thorough assessment by
    clinical history, physical examination and other investigations
    before they are referred to MRI. The Clinical Referral
    Guidelines from Hong Kong College of Radiologists1 and the
    Appropriateness Criteria from American College of Radiology2
    provide good guidance concerning the referral for MRI of the
    spine.                                                                    Figure 1a. Sagittal T2W            Figure 1b. Localizer image of
                                                                              image of lumbar spine. Note        the same patient in figure 1a.
                                                                              the inferior scan range only       Note the limited image quality.
     Technical considerations                                                 reaches upper sacrum.              The localizer image facilitates
                                                                                                                 the counting of vertebral
                                                                                                                 bodies and planning of
                                                                                                                 imaging planes, but the image
    MRI of the spine is a time consuming investigation. It is                                                    quality is insufficient for lesion
    important that the examination can address the clinical                   Figure 1. MRI of lumbar spine.     assessment.
    concern in a time-efficient manner so that more patients can
    be served. Limiting the scanning time also reduces the chance
                                                                         The plane of scan is another important technical consideration.
    of patient movement which may jeopardize the image quality.
                                                                         Sagittal plane is essential and is usually the first scanning plane
                                                                         to obtain, while axial plane is also needed for most situations.
    The range of scan is one of the most important considerations.
                                                                         The axial imaging plane of the spine refers to the plane parallel
    MRI of the spine can be divided into three regions namely
                                                                         to the intervertebral discs or perpendicular to the spinal
    cervical spine, thoracic spine and lumbar spine. MRI of cervical
                                                                         canal. As the spine is a curved structure, the axial planes at
    spine usually covers skull base to T1; MRI of thoracic spine
                                                                         different levels of the spine would have different orientations. In
    usually covers C7 to L1; while MRI of lumbar spine usually
                                                                         patients with severe kyphoscoliosis, the planning of scanning
    covers T12 to upper sacrum. The sacrum and coccyx are
                                                                         planes may be complex. When indicated by relevant clinical
    often not fully included by a routine protocol of MRI of lumbar
                                                                         information and imaging findings, additional scanning planes
    spine (Figure 1a). Therefore, if complete assessment of the
                                                                         such as oblique (angled sagittal) planes and coronal planes
    sacrum and coccyx is needed, it should be specified in the
                                                                         can be performed. For instance, in cervical region where the
    request. For MRI of lumbar spine and thoracic spine, localizer
                                                                         neural foramina have oblique orientation, imaging in oblique
    images would include cervical region to facilitate the counting
                                                                         (angled sagittal) planes may improve the assessment of the
    of vertebral bodies (Figure 1b). These localizer images are at
                                                                         neural foramina3-5.
    lower resolution and insufficient to provide proper assessment

2   HKMA CME Bulletin
                                                                                                                            www.hkmacme.org
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
SPOTlight

                                                                                appropriate, referring clinicians should request MRI of a
                                                                                targeted region of the spine to focus on the clinical concern.
                                                                                Referring clinicians can also help to improve the efficiency and
                                                                                quality of scanning by providing adequate clinical information
                                                                                (e.g. the anticipated diagnosis, the predicted location of
                                                                                neurological deficit etc.), so that radiologists can tailor-make
                                                                                the imaging protocol to address the clinical concern in the
                                                                                most efficient manner with optimal imaging quality.

                                                                                 Limitations of MRI of the spine
                                                                                Despite MRI is an excellent tool for the assessment of the
 Sagittal T1W image   Sagittal T2W image         Sagittal T1W fat-              spine, it has some limitations.
                                                 suppressed post-
                                                 contrast image. Note
                                                 the multiple enhancing
                                                 foci of leptomeningeal
                                                 metastasis
                                           Figure 2. Leptomeningeal
                                           metastasis. Note that
                                           intravenous administration of
                                           Gadolinium-based contrast
                                           agent (GBCA) facilitates the
                                           detection of leptomeningeal
                                           metastasis.
                                       Axial T1W post-contrast image at T1
                                       level of the spine. Note the enhancing
                                       focus of leptomeningeal metastasis.

Various MRI sequences can be chosen to image the spine                           Lateral radiograph of T      Sagittal T1W image of      Sagittal T2W image of
                                                                                 spine                        T spine                    T spine
and their details are beyond the scope of this short article.
Most centers have established MRI protocols with standard                        Figure 3. Lateral radiograph and MRI of thoracic spine in a patient with
sequences for the routine evaluation of common referrals                         posterior spinal fusion. Note the artifacts caused by metallic implant,
such as suspected spinal stenosis, suspected radiculopathy                       with distortion of the contour and signal of the spinal cord, spinal canal,
                                                                                 vertebrae and adjacent soft tissue.
etc. Nevertheless, the application of additional sequences
(e.g. various fat-suppression techniques and vascular
techniques etc.) is sometimes necessary and they are guided
by the clinical information and imaging findings. Intravenous                   Various artefacts can be caused by patient movement,
administration of Gadolinium-based contrast agent (GBCA)                        respiration, swallowing, bowel peristalsis, pulsation from blood
is not without risk and it takes addition time to perform post-                 vessels and CSF flow etc. The presence of metallic implants,
contrast sequences. The need for GBCA injection should be                       even when they are MRI compatible, can cause artifacts
evaluated for individual patients. For instance, if MRI of the                  (Figure 3). There are various imaging techniques to reduce
spine is performed with the aim to look for leptomeningeal                      these artifacts; nevertheless, additional imaging modalities are
metastasis (Figure 2), administration of GBCA is indicated. On                  occasionally needed to provide complementary assessment.
the other hand, if a patient is already known to have multiple
spinal metastases and MRI is performed with the sole purpose                    Comparing with MRI, CT provides better visualization of
to assess acute cord compression for treatment planning,                        cortical bone and calcification. CT is complementary to MRI
GBCA administration may not be necessary. Injection of GBCA                     for evaluating the bone in tumors with osseous involvement,
is usually needed in some situations such as the assessment                     and in conditions like ossified posterior longitudinal ligament8,9
of intra-spinal tumors, infectious conditions, inflammatory                     (Figure 4).
conditions, demyelinating conditions, and for the differentiation
of scar tissue from disc material in patients with previous                     In trauma cases when time and clinical stability of patient is
spine surgery 3,6,7 etc. When necessary, discussion with                        the paramount concern, radiographs and CT scan can provide
radiologists is recommended to determine the need of GBCA                       rapid radiological assessment of the spine when necessary.
administration.                                                                 MRI remains a good problem-solving tool if the status of spinal
                                                                                cord and soft tissue injuries need to be evaluated.
The overall examination time in MRI depends on many factors
such as the actual scanning range, the number of imaging                        Conventional MRI of the spine is performed in supine position.
planes, the number of sequences in each imaging plane and                       Most MRI scanners cannot assess the dynamic changes of
the parameters of each imaging sequence. It typically takes                     the spinal components during physiological loading and in
20 to 30 minutes to scan one region of the spine and around                     various flexion or extension positions. Traditional investigation
an hour to scan the whole spine in common protocols. When                       like lateral flexion-extension radiography still remains valuable

www.hkmacme.org                                                                                              HKMA CME Bulletin                                   3
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
SPOTlight

                                                                                     Reference
                                                                                      1.   Hong Kong College of Radiologists. Clinical Referral Guidelines. Available at
                                                                                           https://www.hkcr.org/lop.php/clinical_referral_guideline. Accessed 29 Oct
                                                                                           2018.
                                                                                      2.   American College of Radiology. ACR Appropriateness Criteria. Available at
                                                                                           https://acsearch.acr.org/list. Accessed 30 Oct 2018.
                                                                                      3.   American College of Radiology. ACR-ASNR-SCBT-MR-SSR Practice
                                                                                           parameter for the performance of magnetic resonance imaging (MRI) of the
                                                                                           adult spine. Available at https://www.acr.org/-/media/ACR/Files/Practice-
                                                                                           Parameters/MR-Adult-Spine.pdf?la=en. Accessed 30 Oct 2018.
                                                                                      4.   Shim JH, Park CK, Lee JH, et al. A comparison of angled sagittal MRI and
                                                                                           conventional MRI in the diagnosis of herniated disc and stenosis in the
                                                                                           cervical foramen. Eur Spine J. 2009; 18: 1109-1116.
     Sagittal T2W image of C-spine               Sagittal T1W image of C-spine        5.   Park HJ, Kim SS, Lee SY, et al. A practical MRI grading system for cervical
                                                                                           foraminal stenosis based on oblique sagittal images. Br J Radiol. 2013; 86:
                                                                                           20120515.
                                                                                      6.   Van Gothem JW, Parizel PM, Kinkins JR. Review article: MRI of the post-
                                                                                           operative lumbar spine. Neuroradiology. 2002; 44: 723-739.
                                                                                      7.   Bradley WG. Use of contrast in MR imaging of the lumbar spine. Magn
                                                                                           Reson Imaging Clin N Am. 1999; 7: 439-457.
                                                                                      8.   Kang MS, Lee JM, Zhang HY, et al. Diagnosis of cervical OPLL in lateral
                                                                                           radiograph and MRI: Is it reliable? Korean J Spine. 2012; 9: 205-208.
                                                                                      9.   Abiola R, Rubery P, Mesfin A. Ossification of the posterior longitudinal
                                                                                           ligament: etiology, diagnosis, and outcomes of nonoperative and operative
                                                                                           management. Global Spine J. 2016; 6: 195-204.

                                                                                                                                    Complete Spotlight, 1 CME Point
                                                                                                                                    will be awarded for at least five correct

      Axial T2W image at C3 level of the spine     CT scan of C-spine
                                                   reformatted in sagittal plane
                                                                                     Q&A Self-Assessment
                                                                                         Questions:
                                                                                                                                    answers

     Figure 4. Ossified posterior longitudinal ligament. Note that MRI and CT        Answer these on page 11 or make an online submission at: www.hkmacme.org.
     provides complementary assessment. MRI provides excellent evaluation of         Please indicate whether the following statements are true or false.
     the spinal canal and status of spinal cord, while CT scan provides excellent    1. Radiologists can modify the imaging protocol to improve the
     demonstration of the ossification.
                                                                                        efficiency and quality of MRI of the spine for individual patients.
                                                                                     2. MRI of cervical spine covers C7 to L1 levels.
    in assessing the segmental instability of the spine. Although                    3. All MRI of lumbar spine would fully include the whole sacrum and
    upright MRI and kinematic MRI etc. are under development,                           coccyx without the need to specify in the request.
    their availability is extremely limited and their application needs              4. In MRI of the spine, the axial imaging planes at different levels of
    further evaluation.                                                                 the spine can have different orientations.
                                                                                     5. Imaging in oblique planes may improve assessment of the neural
    Last but not least, the general considerations of MRI safety                        foramina at cervical region.
    should always be observed for MRI of the spine. In patients
    with contraindications to MRI, clinicians should collaborate                     6. Intravenous administration of Gadolinium-based contrast
                                                                                        agent (GBCA) is usually not necessary for the assessment of
    with radiologists to consider the most appropriate alternative
                                                                                        leptomeningeal metastasis in MRI of the spine.
    investigations.
                                                                                     7. In patients with prior spinal surgery, intravenous administration
                                                                                        of Gadolinium-based contrast agent (GBCA) can help to
     Conclusion                                                                         differentiate scar tissue from disc material.
                                                                                     8. It only takes one to two additional minutes to perform a typical
    There are many technical considerations for MRI of the spine.                       MRI of the whole spine comparing with a typical MRI of the
    By choosing the appropriate scanning ranges and providing                           lumbar spine for the same patient.
    adequate clinical information, referring clinicians can help                     9. MRI-compatible metallic implants can still cause artifacts on MRI
    radiologists to plan the scanning strategy to provide efficient                     images.
    and high quality imaging.
                                                                                     10. CT and MRI are complementary in the assessment of ossified
                                                                                         posterior longitudinal ligaments.

                                                                                    Answer to December 2018
                                                                                    Spotlight 1-Fighting against hypercholesterolemia with statin for
                                                                                    over 20 years since the 4 S Study 1994
                                                                                    1. F   2. F   3. F    4. F   5. F    6. T   7. T    8. T    9. T    10. T

                                                                                    Spotlight 2-Short Notes on MRI-MRI Safety
                                                                                    1. F   2. F   3. F    4. T   5. F    6. F   7. T    8. T    9. T    10. T

4   HKMA CME Bulletin
                                                                                                                                                 www.hkmacme.org
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
Cardiology

                                                                                                              The content of the January Cardiology Series is provided by:
                                                                                                                                                 Dr. CHEUNG Ling Ling
Complete Cardiology case,                                                                             MBBS(HK), MRCP(UK), FHKCP, FHKAM(Med), Specialist in Cardiology
0.5 Cardiology will be awarded for
at least 2 correct answers in total

                                               A 54 year old lady with heart murmur
  A 54-year-old woman, suffering from hypertension complaint of increasing shortness of breath and decreased
  exercise tolerance. Physical examination revealed a 2/6 diastolic aortic murmur over left lower sternal border.
  Electrocardiography showed normal sinus rhythm. Transthoracic echocardiography was performed and the
  images were shown below.

         Figure 1. Parasternal short axis view of left ventricle
         Quadricuspid aortic valve (QAV) is a rare congenital cardiac
         anomaly with an incidence of 0.01-0.04% causing aortic
         regurgitation usually in the fifth to sixth decade of life.

                                                                                             Figure 2. 5 chamber view

                                                                                                              Figure 3. M mode of left ventricle
                                                                                                              The LVDD measured 6.2cm which is dilated

  Q&A
               Please answer ALL questions
               Answer these on page 11 or make an online submission at: www.hkmacme.org

  1) What is the diagnosis in Figure 1?                                                   3) What abnormality is shown in Figure 3?
       A)   Unicuspid aortic valve                                                           A) Dilated left ventricle
       B)   Bicuspid aortic valve                                                            B) Impaired left ventricular ejection fraction
       C)   Tricuspid aortic valve                                                           C) Left ventricular hypertrophy
       D)   Quadricuspid aortic valve
                                                                                          4) What is the commonest congenital anomaly
  2) What condition is mostly commonly caused by the                                         associated with Figure 1?
     pathology in Figure 1 (as shown in Figure 2)?
                                                                                             A)   Coronary artery anomalies
       A)   Aortic stenosis                                                                  B)   Atrial septal defect
       B)   Aortic regurgitation                                                             C)   Patent ductus arteriosus
       C)   Mitral regurgitation                                                             D)   Mitral valve prolapse
       D)   Tricuspid regurgitation

 www.hkmacme.org                                                                                                       HKMA CME Bulletin                                     5
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
Cardiology

    December Answers
     1.E                                                                   echo. Absence of reciprocal ST depression at anterior leads
                                                                           made inferior STEMI less likely in this situation. In addition
     This is a common scenario encountered almost every day in             normal wall motion from focus echo is helpful in ruling out
     A&E: a patient with ST segment elevation in ECG. The chest            this potentially fatal possibility. Hypertrophic cardiomyopathy
     pain as described was pleuritic in nature with pericardial rub        (HCM) is associate with “thick wall” especially at interventricular
     on examination which was unrelieved by sublingual nitrate,            septum which may result in dynamic left ventricular outflow tract
     these features were rather unusual in myocardial infarction.          obstruction. Clinical manifestation included exertional angina
     The ECG demonstrated diffuse ST segment elevation with the            and dyspnea, which are not evident in this case. Absence of
     exception of aVR. Given the scenario of acute chest pain with         left ventricular hypertrophy by voltage criteria is uncommon in
     ST elevation, the differential diagnoses included acute inferior      HCM. Overt hypothyroidism instead of hyperthyroidism could
     STEMI, acute pericarditis and acute aortic dissection with flap       associate with circumferential pericardial effusion.
     extension to right coronary artery. Blood tests like cardiac
     enzymes, D-dimer and even urgent CT aortogram/pulmonary               4.C
     angiogram are reasonable investigations to order but are
     time-consuming to process. Thus, the point-of-care focus              The first line treatment for acute pericarditis should be
     echocardiography allowed us to make an instant diagnosis,             non-steroidal anti-inflammatory drug (NSAID) preferably
     i.e. absence of regional wall motion abnormalities (RWMA)             indomethacin and ibuprofen if there were no contraindication
     +/-presence of pericardial effusion together with diffuse ST          like NSAID allergy and active gastrointestinal bleeding. The
     elevation basically confirmed the diagnosis of acute pericarditis.    recommended dosage would be indomethacin 25-50mg
                                                                           TDS and ibuprofen 400-600mg TDS. Prednisolone should be
     2.B                                                                   reserved as second line treatment in view of risk of relapses
                                                                           upon tapering and withdrawal. Pericardiocentesis should
     The point-of-care focus echo in parasternal long-axis view:           be performed in case patient develops cardiac tamponade,
                                                                           i.e. with hypotension and tachycardia but these features are
                                                                           not present in this patient. Pericardial fluid aspiration should
                                                                           be considered if there is suspicion of unknown bacterial or
                                                                           neoplastic etiology. Percutaneous coronary intervention and
                                                                           betablocker would be indicated in acute coronary syndrome but
                                                                           not in pericarditis.
                                                                           5.B
                                                                           Colchicine 0.5mg daily is the drug of choice (those less than
                                                                           70kg) for incessant or recurrent pericarditis as recommended
                                                                           by the current ESC guideline. It has been proven in the
                                                                           randomized controlled trial (CORP 1) that colchicine reduced
                                                                           the risk of recurrent pericarditis by 56% at 18 months. There
                                                                           is no data to suggest aspirin is superior to other NSAIDs.
                                                                           Should prednisolone consider as second line therapy, the
     RV: Right ventricle; IVS: Interventricular septum; AV: Aortic         prescription dosage is 0.25-0.5mg/kg instead of 10mg daily.
     valve; LA: Left atrium; MV: Mitral valve; PS: Posterior segment       Surgical intervention i.e. pericardiectomy is regarded as last
     of left ventricle. P.E.: Pericardial effusion. Ao: Aorta.             resort (fourth line), it is indicated only if all the medical therapies
                                                                           (NSAID, colchicine, steroid, intravenous immunoglobulin,
     The most striking abnormality from this parasternal long-             azathioprine) have been failed. Psychiatry referral is not
     axis view was the presence of pericardial effusion i.e. echo-         appropriate in view of persistent pleuritic chest pain and high
     lucent (dark) space surrounding the heart. The right ventricle        CRP.
     was not grossly dilated in the view. To distinguish pericardial
     effusion from pleural effusion, the descending aorta was the
     landmark structure to identify. As the rule of thumb, pericardial
     effusion should be anterior to descending aorta which was              Reference
     shown clearly in the image, whereas pleural effusion should be
     posterior to descending aorta.                                          1. Adler Y, Charron P, Imazio M, et al. 2015 ESC guidelines for the diagnosis
                                                                                and management of pericardial diseases: the Task Force for the Diagnosis
     3.D                                                                        and Management of Pericardial Diseases of the European Society of
                                                                                Cardiology (ESC) endorsed by: the European Association for Cardio-
     According to diagnostic criteria of European Society of                    Thoracic Surgery (EACTS). Eur Heart J 2015;36:2921-64.
     Cardiology (ESC), this patient fulfilled at least three out of four     2. Snyder M, Bepko J, White M. Acute Pericarditis: Diagnosis and
     criteria which included pleuritic chest pain, pericardial rub and          Management. Am Fam Physician. 2014;89(7):553-560.
     pericardial effusion although the ST elevation from this ECG            3. Markel G, Imazio M, Brucato A, et al. Prevention of recurrent pericarditis with
                                                                                colchicine in 2012. Clin Cardiol. 2013 Mar. 36:125-8.
     may not be the classical one. Stress cardiomyopathy, i.e.
                                                                             4. Imazio M, Brucato A, Cemin R, et al. A randomized trial of colchicine for
     apical ballooning syndrome, is rather unlikely as there was no             acute pericarditis. N Engl J Med 2013;369:1522-8.
     “paradoxical” dilatation of apex in systole as suggested by the         5. Imazio M, Brucato A, Cemin R, et al. Colchicine for recurrent pericarditis
                                                                                (CORP): a randomized trial. Ann Intern Med 2011;155:409-14..

                                                                                              The content of the December ECG Series is provided by:
                                                                                                                            Dr. KAM Ka Ho, Kevin
                                                                                            MBChB (CUHK), FHKAM (Medicine), Specialist in Cardiology

6   HKMA CME Bulletin
                                                                                                                                      www.hkmacme.org
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
Dermatology
                                                                                                                         Dermatology Series for January 2019 is provided by:
                                                                                             Dr. LEUNG Wai Yiu, Dr. TANG Yuk Ming, William, Dr. CHAN Hau Ngai, Kingsley,
                                                                                                                         Dr. KWAN Chi Keung and Dr. CHANG Mee, Mimi
                                                                                                                                  Specialists in Dermatology & Venereology
Complete Dermatology case,
0.5 Dermatology will be awarded for
at least 2 correct answers in total

                                                                A girl with rough nails for one year
                                                                A 11-year-old girl presented with a one-year history of progressive
                                                                ‘rough nails’ which raised her parent’s concern. The girl had no
                                                                history of other skin diseases such as lichen planus, psoriasis, eczema
                                                                or alopecia areata, and her family history was unremarkable. On
                                                                examination, she had sandpaper-like nails and small superficial pits on
                                                                all her finger nails.

  Q&A
              Please answer ALL questions
              Answer these on page 11 or make an online submission at: www.hkmacme.org

  1. What is the clinical diagnosis?                                                       3. What other parts of body would you examine ?
      A.   Onychomycosis                                                                       A.   Scalp and hair
      B.   Lichen planus                                                                       B.   Oral mucosa
      C.   Psoriasis                                                                           C.   Complete skin examination
      D.   Trachyonychia                                                                       D.   All of the above

  2. Who tend to be most likely affected by this skin                                      4. What is the most appropriate treatment for this
     disease?                                                                                 patient?
      A. Children                                                                              A. Reassurance
      B. Adult male                                                                            B. Oral anti-fungal drug
      C. Those with positive family history or affected                                        C. Intralesional steroid to the nail fold or systemic
         monozygotic twins                                                                        corticosteroids.
      D. Elderly                                                                               D. Phototherapy such as topical PUVA (psoralen
                                                                                                  and ultraviolet A therapy)

December Answers
 1. C                                                                                      2. A
    The diagnosis are Fordyce Spots. Fordyce spots                                            Fordyce spots can be diagnosed clinically with no
    are a variant of sebaceous glands. They may                                               further investigation needed.
    present at birth but become bigger after puberty.
                                                                                           3. False
    Fordyce spots are small yellowish or white papules
    or spots that can appear on vermillion border of the                                      Fordyce spots is benign variant of sebaceous
    lips, the glans or shaft of the penis, or the vulva of                                    glands and will not progress to cancer.
    the female.                                                                            4. E
                                                                                              Fordyce spots are harmless and therefore no
                                                                                              further treatment is needed. Different treatment
                                                                                              modalities including CO 2 laser surgery,
                                                                                              electrosurgery, surgery and oral retinoid can help
                                                                                              to improve the condition.
                                                                                                               Dermatology Series for December 2018 is provided by:
                                                                                   Dr. CHAN Hau Ngai, Kingsley, Dr. TANG Yuk Ming, William, Dr. KWAN Chi Keung,
                                                                                                                     Dr. LEUNG Wai Yiu and Dr. CHANG Mee, Mimi
                                                                                                                            Specialists in Dermatology & Venereology

www.hkmacme.org                                                                                                          HKMA CME Bulletin                                     7
Short Notes on MRI - MRI of the adult spine - www.hkmacme.org January 2019 - If you're a HKMA Member, please click the ...
HKMA CME Lecture Online Scheme 2019 Policy
To facilitate members in joining CME Lectures, the HKMA launched the HKMA CME Lecture Online Scheme. The Medical
Council of Hong Kong approved that by viewing the lecture in real-time and completing the online quiz, CME points will be
counted as attending the lecture physically under the “CME Programme for Practising Doctors who are not taking CME
Programme for Specialist.” for non-specialists.

                                                         Step 1

                                       Add “HKMA CME Live” as Facebook friend

                                                         Step 2

                   Fill in Online Registration Form using HKMA website/Scan QR Code on CME Bulletin
                                     (Must provide Facebook Account Name and Email)

                                                         Step 3

                                       Receive an email with Facebook Group URL
                             Join group by clicking the URL and press “request to join group”
                                  (Please join the group 3 days before the online lecture)

                                                         Step 4

                     HKMA will approve doctors’ request to join the group 2 days before the lecture

                                                         Step 5

                                   Watch Real-time live broadcast at designated time

                                                         Step 6

                 Complete lecture quiz (10 Q&A) and answer questions within two hours after the lecture

                                                         Step 7

                   Receive CME point(s) if doctors completed the quiz online with at least 70% correct

Policy for HKMA CME Lecture Online Scheme
1.  As approved by the Medical Council of Hong Kong, the CME Accreditation for CME Lecture Online is for non-
    specialists only.
2. Doctors must have a Facebook Account to join the CME Lecture Online.
3. Registration can be done by scan the QR code on CME Bulletin Cover and complete the online form or registration
    through HKMA website
4. Doctors can either attend in person or watch lecture online at one point in time.
5. Doctors must watch the lecture at real time
6. Doctors should complete lecture quiz within 2 hours after the lecture. Late submission of the quiz will not be
    accepted. 1 CME point will be awarded for doctors with 70% or above correct answer afterward.
7. One Facebook Group is intended for one specific CME Lecture only. Doctors must register with the HKMA
    Secretariat for specific lecture and email will be sent to doctors for joining the Facebook group and to gain CME
    point.
8. You are recommended to connect to Wi-Fi on your mobile device or computer while watching the lecture through
    Facebook Live. Unstable internet connection will cause interruption to your viewing.
9   In case of technical issue and broadcast interruption, please be patient while our technicians will work on fixing the
    problem; the video should resume in a few minutes.
10. Due to copyright issue, the Facebook group is exclusive for doctors who have registered; and the video recording,
    PowerPoint slides and quiz link MUST not be shared with non-registrants.
Answer Sheet
                                                                                                                          January 2019

                                         ANSWER SHEET

     SPOTlight
                                                         at least five

      1        2         3        4        5         6         7          8         9        10

     Cardiology                                     Dermatology
                   at least two                                    at least two
                                                                                                                  A maximum of 20 points
      1        2         3        4                  1         2          3         4                             can be awarded for self-
                                                                                                                  study per year and no
                                                                                                                  upper limit of CME points
                                                                                                                  for attending CME lectures

CME Physical Lecture Policy and Procedure
Registration                                                                  Information for Participants
1.   Please complete the reply slip and return to HKMA Secretariat in         Special weather arrangement
     person or by fax/mail/email.                                             When Tropical Storm Warning Signal No. 8 (or above) or a
2.   Enrollment priorities will be given to doctors who have purchased        Black Rainstorm Warning Signal is in force within 3 hours of the
     packages. For Community Network Lectures, priorities will be             commencement time, the relevant CME function will be cancelled. (i.e.
     given to doctors from that Community Network with Packages,              CME starting at 2:00 pm will be cancelled if the warning signal is hoisted
     then doctors from that Community Network.                                or in force any time between 11:00 am and 2:00 pm).
3.   No walk in or on-site payment will be accepted. Attendance
     without registration will not be recognized and CME point will not       The function will proceed as scheduled if the signal is lowered three
     be accredited.                                                           hours before the commencement time. (i.e. CME starting at 2:00 pm
4.   Please ensure that your registration is confirmed before attending       will proceed if the warning signal is lowered at 11:00 am, but will be
     lecture. Only successfully registered doctors who paid could             cancelled even if it is lowered at 11:01 am).
     attend the lecture.
5.   The HKMA Secretariat will notify doctors who have successfully           When Typhoon No. 8 Signal or a Black Rainstorm signal is in force
     enrolled to arrange for payment. If doctors have not arranged for        after CME commencement, announcement will be made depending on
     payment within a specified period after the notification, the seat       the conditions as to whether the CME will be terminated earlier or be
     will be released to doctors on waiting list without further notice.      conducted until the end of the session.

Payment                                                                       The above are general guidelines only. Individuals should decide on
1.  All HKMA CME lectures that involve registration and enrollment            their CME attendance according to their own transportation and work/
    through the HKMA would require the collection of lecture fee              home location considerations to ensure personal safety.
    (unless otherwise specified).
2.  The lecture fee is $50 for HKMA members and $100 for non-                 General lecture policy
    members per lecture.                                                      1.  Doctor should sign for own CME.
3.  Cash payments have to be paid in person at HKMA Secretariat               2.  Registration will cease when Q & A Session starts.
    and cheque payments have to be mailed or paid in person at                3.  No recording unless permission is granted by the HKMA.
    HKMA Secretariat.                                                         4.  The HKMA will investigate when non-compliance at CME Session
4.  Fee can be paid together in one cheque for lecture within the                 is reported, further action will be considered to ensure all CME
    same month. Only combined cheque payment for not more than                    activities are properly held.
    2 packages will be accepted.                                              5.  For enquiries, please contact the CME Department of the HKMA
5.  No refund or transfer will be allowed after payment is made.                  Secretariat at 2527-8452.
    Payment cannot be transferred to other lectures or for other
    specified doctors.
Advertorial

                                                                                Professor Ivan Fan Ngai HUNG
     Update on Influenza                                                        Clinical Professor
                                                                                Chief, Division of Infectious Diseases,

     Vaccination – Herd                                                         Department of Medicine
                                                                                Li Ka Shing Faculty of Medicine
                                                                                The University of Hong Kong

     Immunity, Immunogenicity
     and Heterologous Protection
     The Hong Kong Medical Association (HKMA)                   severity was high in all age groups (children, adults
     organized a Continuous Medication Education (CME)          and elderlies).6 The epidemic was likely a result of the
     programme lunch lecture on October 31, 2018                Singaporean strain migrating to the US, which was
     entitled Update on Influenza Vaccination, which was        not contained in the flu shots then. In Hong Kong last
     sponsored by AstraZeneca Hong Kong. Professor              year, there was a large summer peak that caused
     Ivan Fan Ngai Hung (Specialist in Infectious Disease,      400-500 deaths, 7 again likely exacerbated by an
     Clinical Professor, Department of Medicine, Li Ka          antigenic mismatch. According to Prof. Hung, since
     Shing Faculty of Medicine, The University of Hong          there had not been a summer peak this year, a large
     Kong) spoke on the latest key issues in influenza          winter surge might be expected.
     vaccination, which include strategies for reducing
     infections, hospitalizations and deaths, enhancing         Reducing Infections, Hospitalizations and
     immunogenicity, and achieving heterologous protection.     Deaths: Herd Immunity

     Latest Worldwide Challenges: Rising Mortality              Different kinds of vaccines are available for
     and Antigenic Mismatch                                     influenza prevention, including the common
                                                                inactivated quadrivalent intramuscular vaccines,
     In terms of influenza-related mortality worldwide, the     the life-attenuated intranasal vaccines (LAIVs), and
     World Health Organization (WHO) has increased the          recombinant vaccines (in the US). The questions are
     estimate to up to 650,000 deaths annually.1 For last       which to use and on what target populations. The
     year, 2017-2018, the US Centers for Disease Control        LAIVs have demonstrated high efficacy in young
     and Prevention (CDC) estimated 79,400 deaths from          children aged 6 months to 7 years (compared with
     influenza.2 In Hong Kong, seasonal influenza caused        placebo in trials and with inactivated vaccines in a
     501 reported deaths in Winter 2015 alone. 3 High-          meta-analysis), 8 and the intranasal administration
     risk populations such as elderlies, infants aged ≤2,       is suitable for children who may be more repelling
     patients with chronic illnesses (e.g. heart condition      against needle injections. In the US, LAIVs were not
     or diabetes) and smokers are particularly vulnerable.      immunogenic for the 2015-2016 Bolivian strain, 9
     There are also the continuous threats of antigenic         but are recommended by the CDC this year. 10
     shifts (esp. in the hemagglutinin H1 and H3 families)      Contraindications include egg allergy (as in other
     and the emergence of new subtypes (esp. from the           inactivated vaccines), aspirin therapy and Reye
     H5 and H7 families). In combating against influenza        syndrome; precautions may include pregnancy or
     epidemics, some major concerns are that i) people          a weakened immune system (e.g. post-transplant
     are at risk but not immunized, ii) protection from         recipients).11
     vaccination may not last through to the summer
     peak season (particularly among elderlies), and iii) the   According to Prof. Hung, the best influenza
     circulating seasonal influenza subtype may not match       prevention strategy would be universal vaccination;
     with that of the vaccine.                                  while it is not yet feasible, a newer notion of protection
                                                                involves herd immunity. The idea is that vaccinating
     Since the 1960s, the US have established continuous        children, in particular kindergarten and primary school
     surveillance on the impact and burden of influenza,4       children, may block influenza transmission from
     which now includes monitoring three major indicators:      within schools toward families (including to parents
     outpatient visits, hospitalizations and deaths from        and grandparents) and communities. This was
     influenza-like illnesses. While the US CDC estimated       demonstrated in a 2010 study in Alberta, Canada in
     that vaccination prevented 5 million illnesses and         the relatively close Hutterite communities.12,13 A total
     71,000 hospitalizations in 2015-2016, 5 in 2017-           of 947 children and adolescents aged 36 months to
     2018, for the first time ever, the estimated influenza     15 years (83% coverage) received the study vaccine

12   HKMA CME Bulletin
                                                                                                              www.hkmacme.org
Advertorial

and 2,326 received placebo (hepatitis A vaccine; 79%      –        Children may be administered the life-attenuated
coverage). Among non-recipients in the communities,                intranasal spray vaccine, without the need of
3.1% vs. 7.6% had confirmed influenza illness (by                  using needles.
RT-PCR), for a protective effectiveness of 61%
(95% confidence interval: 8-83%, p = 0.03). More          –        For enhancing immunogenicity in elderlies and
recently, the UK childhood LAIV programme offered                  protection in case of antigenic drifts, strategies
universal vaccination to children aged 2-11 in certain             include using i) an immunologic adjuvant, ii)
pilot areas,14 and found that cumulative emergency                 a high-dose vaccine, or iii) topical imiquimod
department respiratory attendances, influenza-                     before intradermal vaccination.
confirmed hospitalisations and intensive care unit
admissions were consistently lower (although mostly
non-significantly), in both targeted and non-targeted
age groups compared with non-pilot areas.                     References
                                                              1.   World Health Organization. https://www.who.int/mediacentre/news/
Enhancing Immunogenicity and Heterologous                          statements/2017/flu/en/. Last accessed: Nov 8, 2018.
Protection                                                    2.   US Centers for Disease Control and Prevention. https://www.cdc.gov/flu/
                                                                   about/burden/estimates.htm. Last accessed: Nov 8, 2018.
As mentioned, enhancing immunogenicity has                    3.   Department of Health. https://www.dh.gov.hk/english/press/2016/160128.
                                                                   html. Last accessed: Nov 8, 2018.
been an old problem in influenza vaccination, which
                                                              4.   US Centers for Disease Control and Prevention. https://www.cdc.gov/flu/
is particularly important for elderlies. Prof. Hung                about/burden/index.html. Last accessed: Nov 8, 2018.
discussed several strategies for tackling with the            5.   US Centers for Disease Control and Prevention. https://www.cdc.gov/flu/
issue. First, the use of an adjuvant with trivalent                about/disease/2015-16.htm. Last accessed: Nov 8, 2018.
inactivated influenza vaccine had been reported to            6.   US Centers for Disease Control and Prevention. https://www.cdc.gov/flu/
                                                                   about/season/flu-season-2017-2018.htm. Last accessed: Nov 8, 2018.
increase effectiveness by about 20-30%.15 Second,
                                                              7.   Centre for Health Protection, Department of Health. Flu Express.
high-dose vaccine (at 4 times normal dosage) had                   15(5). Available at: https://www.chp.gov.hk/files/pdf/fluexpress_
been shown to increase immunogenicity by about                     week05_08_02_2018_eng.pdf. Last accessed: Nov 8, 2018.
twofold, 16 but at an increased cost. Third, Prof.            8.   Osterholm T, Kelley S, Sommer A, Belongia A. Effcacy and effectiveness of
Hung and colleagues had performed studies that                     influenza vaccines: a systematic review and meta-analysis. Lancet Infectious
                                                                   Disease. 2012;12:36-44.
applied topical imiquimod before administering the
                                                              9.   Pebody R, McMenamin J, Nohynek H. Live attenuated influenza vaccine
intradermal trivalent vaccine. In a prospective trial              (LAIV): recent effectiveness results from the USA and implications
of 91 participants (mean age 73), 17 the approach                  for LAIV programmes elsewhere. Archives of Disease in Childhood.
demonstrated an increased seroconversion rate                      2018;103(1):101-105.
                                                              10. Grohskopf LA, Sokolow LZ, Fry AM, et al. Update: ACIP recommendations
(compared with an aqueous cream) that was
                                                                  for the use of quadrivalent live attenuated influenza vaccine (LAIV4) — United
sustained from day 7 to year 1 (p < 0.001) and was                States, 2018–19 influenza season. Morbidity and Mortality Weekly Report.
associated with fewer hospitalizations for influenza or           2018;67(22):643-645.
pneumonia (p < 0.05). Imiquimod is a toll-like receptor       11. FluMist Quadrivalent [prescribing information RAL-FLUQV7]. Gaithersburg,
                                                                  MD, USA: MedImmune; 2018.
7 agonist that attracts dendritic cells, which likely
                                                              12. Loeb M, Russell M, Moss L, et al. Effect of influenza vaccination of children
enhanced antigen presentation and downstream                      on infection rates in Hutterite communities. JAMA. 2010;303(10):943-950.
T-cell and B-cell activation at local lymph nodes.17 In       13. Wang B, Russell M, Moss L, et al. Effect of influenza vaccination of children
a further phase 2b/3 trial (n = 160), topical imiquimod           on infection rate in Hutterite communities: follow-up study of a randomized
and intradermal vaccination were found to also                    trial. PLoS ONE. 2016;11(12):e0167281.

significantly improved immunogenicity against non-            14. Pebody R, Sinnathamby M, Warburton F, et al. Uptake and impact of
                                                                  vaccinating primary school-age children against influenza: experiences
vaccine strains, such as the antigenically drifted H3N2           of a live attenuated influenza vaccine programme, England, 2015/16.
strain of 2015 that was not included in the 2013-2014             Eurosurveillance. 2018;23(25):1700496.
recommended vaccine.18                                        15. Vesikari T, Knuf M, Wutzler P, et al. Oil-in-water emulsion adjuvant with
                                                                  influenza vaccine in young children. New England Journal of Medicine.
                                                                  2011;365(15):1406-1416.
Summary Points                                                16. DiazGranados CA, Dunning AJ, Kimmel M, et al. Efficacy of high-dose
                                                                  versus standard-dose influenza vaccine in older adults. New England Journal
–    Where universal vaccination is not yet                       of Medicine. 2014;371(7):635-645.
     achievable, data have shown that vaccinating             17. Hung F, Zhang J, To K, et al. Immunogenicity of intradermal trivalent
                                                                  influenza vaccine with topical imiquimod: a double blind randomized
     school children reduced overall influenza                    controlled trial. Clinical Infectious Diseases. 2014;59(9):1246-1255.
     infections and related hospitalizations in the           18. Hung F, Zhang J, To K, et al. Topical imiquimod before intradermal trivalent
     community.                                                   influenza vaccine for protection against heterologous non-vaccine and
                                                                  antigenically drifted viruses: a single-centre, double-blind, randomised,
                                                                  controlled phase 2b/3 trial. Lancet Infectious Diseases. 2016;16(2):209-218.

www.hkmacme.org                                                                             HKMA CME Bulletin                                      13
CMEnotifications

                                                               CME Lectures in February 2019

         Organizer/                        : HKMA New Territories West                                             HKMA Hong Kong East Community Network and
         Co-organizer                        Community Network                                                     Primary Care Office of Department of Health (DH)
         Date                              : Thursday, 21 February 2019
         Topic                             : The Current Situation and Latest                                      An Overview of Common Developmental
                                             Management of Nasopharyngeal Carcinoma                                Problems in Children
                                             in Hong Kong
         Speaker                           : Dr. LAM Wing Hung, Eddy                                               Dr. LEE Mun Yau, Florence
                                             Specialist in Otorhinolaryngology                                     Consultant Paediatrician,
                                                                                                                   Child Assessment Service, DH
         Time                              : 1:00 – 2:00 p.m. Registration & Lunch
                                             2:00 – 2:45 p.m. Lecture
                                             2:45 – 3:00 p.m. Q&A Session
         Venue                             : Atrium Function Room, Lobby Floor,                                    The HKMA Wanchai Premises
                                             Hong Kong Gold Coast Hotel, 1 Castle Peak Road,                       5/F, Duke of Windsor Social Service Building,
                                             Gold Coast, Hong Kong                                                 15 Hennessy Road, Wanchai
                                             (                                           )
         Moderator                         : Dr. CHEUNG Kwok Wai, Alvin                                            Dr. YIP Yuk Pang, Kenneth
                                             Chairman,                                                             Vice-chairman (In.),
                                             HKMA NTW Community Network                                            HKMA Hong Kong East Community Network
         Deadline                          : Friday, 8 February 2019
         Fee                               : $50 – Member; $100 – Non-member                                       Free-of-charge (For Members only)
         Capacity &                        : Capacity is 50                                                        Capacity is 80
         Registration
                                               Registration is strictly required on a first come, first served basis. Priority will be given to doctors
                                               practising in NTW districts/HKE districts.
         Enquiry                           : Miss Antonia LEE                                                      Ms. Candice TONG

                                           : Tel: 2527 8285. *Please call and confirm that your facsimile has been successfully transmitted to the
                                             HKMA Secretariat if you do not receive confirmation 7 days before the event.
         CME Accreditation                 : Each of the lectures carries 1 CME point under the MCHK/HKMA CME Programme.
                                             Accreditation from various colleges is pending.

                                                                                     REPLY SLIP
     HKMA New Territories West & Hong Kong East Community Networks                                                                                      Fax: 2865 0943
     CME Lectures in February 2019                                                                                                               Please “✓” as appropriate

     I would like to register for the following lecture(s).
                                                                                                                               PAYMENT METHOD
           21 February 2019 (NTW)                          21 February 2019 (HKE)                   The payment shall be made by: (please indicate one of the following
     Name:                                                                                          payment methods, you may refer to p.11 for terms and conditions)

     HKMA No.:
                                                                                                        Cash                    Cheque                    Lecture Package
                                                                                                    Preferred means of communication#:
      Practising location:
                                                                                                    Mobile No. (SMS):                                                           OR
            In New Territories West districts (Please specify *:                                )
            In Hong Kong East districts (Please specify *:                                      )   E-mail:
                                                                                                    #
            Others (Please specify:                                                             )     Please fill in your updated mobile number or email address so that you can be
                                                                                                    notified of your application via SMS/email.

     * Null entry will be treated as non- NTW or HKE member registration.

     Signature:                                                                                            Date:
     Data collected will be used and processed for the purposes related to these events only.

14    HKMA CME Bulletin
                                                                                                                                                         www.hkmacme.org
CME Facebook Live
                                                                                                                                    CMEnotifications

                                                          CME Lectures in February 2019

    Organizer                         : HKMA Central Western & Southern Community                             HKMA Kowloon East Community Network
                                        Network
    Date                              : Wednesday, 20 February 2019                                           Thursday, 21 February 2019
    Topic                             : Physiotherapy for Common Orthopaedic                                  Improving Dyslipidaemia Management: An
                                        Conditions (Part 2)                                                   Update on International Guideline and More
    Speaker                           : Dr. WONG Kam Hung, Francis                                            Dr. CHEUNG Ling Ling
                                        Consultant Physiotherapist                                            Specialist in Cardiology
    Time                              : 1:00 – 2:00 p.m. Registration & Lunch
                                        2:00 – 2:45 p.m. Lecture
                                        2:45 – 3:00 p.m. Q&A Session
    Venue                             : The HKMA Central Premises,                                            V Cuisine, 6/F., Holiday Inn Express Hong Kong
                                        Dr. Li Shu Pui Professional Education Centre,                         Kowloon East, 3 Tong Tak Street, Tseung Kwan O
                                        2/F., Chinese Club Building,
                                        21-22 Connaught Road, Central
    Moderator                         : Dr. TSANG Chun Au                                                     Dr. CHU Wen Jing, Jennifer
                                        Hon. Treasurer,                                                       Hon. Secretary,
                                        HKMA CW&S Community Network                                           HKMA Kln East Community Network
    Deadline                          : Monday, 11 February 2019
    Fee &                             : $50 – Member; $100 – Non-member. Capacity is 80 for CW&S and Capacity is 48 for Kln East.
    Capacity                            Registration is strictly required on a first come, first served basis. Priority will be given to doctors
                                        practising in CW&S (20 Feb)/ Kln East districts (21 Feb)
    Facebook                          : Please scan the QR code on cover page
    registration
    Enquiry                           : Miss Antonia LEE, Tel: 2527 8285
                                        *Please call and confirm that your facsimile has been successfully transmitted to the HKMA
                                        Secretariat if you do not receive confirmation 7 days before the event.
    Sponsor                           :
    CME Accreditation                 : Each of the lectures carries 1 CME point under the MCHK/HKMA CME Programme.
                                        Accreditation from various colleges is pending.

                                                                                REPLY SLIP
HKMA CW&S & Kln East Community Networks                                                                                                            Fax: 2865 0943
CME Lectures in February 2019                                                                                                               Please “✓” as appropriate

I would like to register for the following lecture(s):
                                                                                                                          PAYMENT METHOD
      20 February 2019 (CW&S)                         21 February 2019 (Kln East)              The payment shall be made by: (please indicate one of the following
Name:                                                                                          payment methods, you may refer to p.11 for terms and conditions)

HKMA No.:
                                                                                                   Cash                    Cheque                    Lecture Package
                                                                                               Preferred means of communication#:
 Practising location:
                                                                                               Mobile No. (SMS):                                                           OR
       In Central, Western & Southern districts (Please specify *:                         )
       In Kowloon East districts (Please specify *:                                        )   E-mail:
                                                                                               #
       Others (Please specify:                                                             )     Please fill in your updated mobile number or email address so that you can be
                                                                                               notified of your application via SMS/email.

* Null entry will be treated as non-CW&S or Kln East member registration.

Signature:                                                                                            Date:
Data collected will be used and processed for the purposes related to these events only.

www.hkmacme.org                                                                                                          HKMA CME Bulletin                                       15
CMEnotifications

                         Antibiotic Stewardship Programme in Primary Care

      Co-organizers                    : HKMA Yau Tsim Mong                                        HKMA Kowloon City                  HKMA Kowloon West
                                         Community Network                                         Community Network                  Community Network
                                            and The Centre for Health Protection (CHP) of the Department of Health (DH)
      Date                             : Tuesday, 19 February 2019                                 Friday, 22 February 2019           Tuesday, 26 February 2019
      Speaker                          : Dr. Leo LUI
                                         Associate Consultant, Infection Control Branch, CHP, DH
      Time                             : 1:00 – 2:00 p.m. Registration & Lunch
                                         2:00 – 2:45 p.m. Lecture
                                         2:45 – 3:00 p.m. Q&A Session
      Venue                            : Crystal Ballroom, 2/F,                                    President’s Room, Spotlight        Fulum Palace, Shop C,
                                         The Cityview Hong Kong,                                   Recreation Club (       ), 4/F.,   G/F, 85 Broadway Street,
                                         23 Waterloo Road, Kowloon                                 Screen World, Site 8, Whampoa      Mei Foo Sun Chuen
                                                                                                   Garden, Hunghom, Kowloon
      Moderator                        : Dr. HO Kit Man, Carmen                                    Dr. CHAN Man Chung, JP             Dr. LEUNG Gin Pang
                                         Committee Member,                                         District Coordinator, HKMA         Hon. Treasurer
                                         HKMA YTM Community Network                                Kln City Community Network         HKMA Kln West Community
                                                                                                                                      Network
      Deadline                         : Friday, 1 February 2019                                   Monday, 4 February 2019            Friday, 8 February 2019
      Fee                              : Free-of-charge (For Members only)

      Capacity                         : Capacity is 80                                            Capacity is 36                     Capacity is 60
                                            Registration is strictly required on a first come, first served basis. Priority will be given to doctors
                                            practising in YTM districts (for lecture on 19 Feb)/Kln City districts (for lecture on 22 Feb)/Kln West
                                            districts (for lecture on 26 Feb).
      Enquiry                          : Ms. Candice TONG                                                                             Miss Antonia LEE
                                            Tel: 2527 8285. Please call and confirm that your facsimile has been successfully transmitted to the
                                            HKMA Secretariat if you do not receive confirmation 7 days before the event.
      CME Accreditation                : Each of the lectures carries 1 CME point under the MCHK/HKMA CME Programme.
                                         Accreditation from various colleges is pending.

                                                                                  REPLY SLIP
        HKMA YTM, Kln City & Kln West Community Networks                                                                                          Fax: 2865 0943
        Antibiotic Stewardship Programme in Primary Care
        I would like to register for the following lecture(s).
            19 February 2019 (YTM)            22 February 2019 (KC)                                             26 February 2019 (KW)
        Name:                                                                                          HKMA No.:
        #
          Mobile No. (SMS):                                                                            OR # E-mail:
        #
            Please fill in your updated mobile number or email address so that you can be notified of your application via SMS/email.

            Practising location:
                In Yau Tsim Mong districts (Please specify *:                                                                                                      )
                In Kln City districts (Please specify *:                                                                                                           )
                In Kln West districts (Please specify *:                                                                                                           )
                Others (Please specify:                                                                                                                            )

        * Null entry will be treated as non-Yau Tsim Mong or Kowloon City or Kowloon West member registration.

        Signature:                                                                                      Date:

        Data collected will be used and processed for the purposes related to these events only.

16   HKMA CME Bulletin
                                                                                                                                                 www.hkmacme.org
Meeting Highlights

HKMA-HKSH CME Programme 2018-2019                                              The HKMA Central, Western and Southern Community Network (CW&SCN) ~
“Update in Medical Practice”                                                   Dr. YIK Ping Yin

  Dr. YAM Chun Yin (right) presenting a souvenir to the                           Group photo taken during the lecture on 5 December 2018           Group photo taken during the lecture on 19 December 2018
  speaker Dr. NG Ping Wing (left) during the lecture on 4                         From left: Dr. POON Man Kay (moderator), Dr. YIK Ping Yin,        From left: Dr. POON Man Kay, Dr. Leo LUI (speaker), Dr. LAW Yim Kwai
  December 2018.                                                                  Prof. Francis WONG (speaker) and Dr. LAW Yim Kwai                 and Dr. TSANG Chun Au (moderator)

The HKMA Hong Kong East Community Network (HKECN) ~                                                                                              The HKMA Kowloon East Community
Dr. CHAN Nim Tak, Douglas                                                                                                                        Network (KECN) ~ Dr. AU Ka Kui, Gary

 Dr. Michele YUEN (left, speaker) receiving the souvenir from Dr. Simon   Dr. Kenneth YIP (left, moderator) presenting the souvenir to Dr. LAU    Dr. Gary AU (left, moderator) presenting the souvenir to Dr. Samuel
 AU (moderator) during the lecture on 6 December 2018                     Ching Wa (speaker) during the lecture on 20 December 2018               LEE (speaker) during the lecture on 6 December 2018

The HKMA New Territories West Community Network (NTWCN) ~
Dr. CHEUNG Kwok Wai, Alvin

                                                                                                                                                  Dr. Ivan SHIU (right, moderator) presenting the souvenir to Dr. WONG
                                                                                                                                                  King Ying (speaker) during the lecture on 13 December 2018

 Dr. LEE Shin Cheung (left, moderator) presenting the souvenir to Dr.     Group photo taken during the lecture on 13 December 2018
 CHEUNG Ling Ling (speaker) during the lecture on 6 December 2018         From left: Dr. Alvin CHEUNG (moderator), Dr. Leo LUI (speaker),
                                                                          Dr. TSANG Yat Fai and Dr. Lambert CHAN

                                                                                                                                                 The HKMA Tai Po Community Network
The HKMA Kowloon West Community Network (KWCN) ~                                                                                                 (TPCN) ~ Dr. CHIU Sik Ho, Bonba
Dr. TONG Kai Sing

 Dr. Bernard CHAN (left, moderator) presenting the souvenir to Dr.        Group photo taken during the lecture on 11 December 2018                  Dr. CHOI Kin (right) presenting the souvenir to Dr. Patrick CHOW (speaker)
 TAM Wing Kei (speaker) during the lecture on 4 December 2018             From left: Dr. Bernard CHAN, Dr. Gabriel YIP (speaker), Dr. LAM Ngam      during the lecture on 4 December 2018
                                                                          (moderator) and Dr. LEUNG Gin Pang

www.hkmacme.org                                                                                                                                    HKMA CME Bulletin                                                             17
You can also read