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Life Sciences Venture Capital Monitor
August 2020                                                                           Antibody

Part of FCF Life Sciences Research Series       Strategic Financing Advisory in Life Sciences
Agenda

FCF LIFE SCIENCES
O V E RV I E W
Overview

Overview                                                                              Service Portfolio                    Facts and Figures

      Focus on Biotechnology, MedTech and HealthTech                                                                                                                                                Over                  Over
                                                                                                                            Life Sciences                     Life Sciences
                                                                                                      Management               Team of                                                           100 years              EUR 2bn
FCF advises innovative companies on arranging, structuring and placing                                                                                          Advisory                        in aggregated        Life Sciences
                                                                                                      Presentation                8
equity and debt transactions in a holistic financing strategy approach.                                                                                          Board                          Life Sciences         transaction
                                                                                        Integrated                         based in Munich
Together with its industry advisors, FCF Life Sciences provides valuable                                                                                                                          experience             volume1
                                                                                         Financial
support on the strategic positioning of its clients                                      Modeling
                                                                                                          Post-                 Over                                                                                       4
                                                                                                                                                                 Access to
      Strategic Financing Advisory                                                                     Transaction               80                                                               Leading             regularly
                                                                                                         Support                                                   > 1000
                                                                                                                            completed Life                                                       EIB advisor        published Life
                                                                                                                                                               international
FCF advises with its dedicated Life Sciences team on the following                      Investor                               Sciences                                                           in Europe           Sciences
                                                                                                                                                                 investors
transaction types:                                                                      Screening                            transactions1                                                                             reports
                                                                                                                                      1 including   Professionals and Life Sciences Advisors
                                                                                                       Investor / IB
                      Venture Capital         Venture Debt                                              Roadshow
                            +                      +
                                                                                                                           Life Sciences Research Series
                       Growth Equity                                                       Due
                                                                                         Diligence
                                                                                         Support                           Venture Capital Monitor                                             Public Equity Monitor
                                                                                                      Equity & Debt                                  is     a    monthly                                        is the most detailed
      Life Sciences Team                                                                               Fundraising
                                                                                                                                                     published overview                                         analysis           of
                                                                                        Financing                                                    of venture capital                                         European     publicly
                                                                                         Strategy                                                                                                               listed   companies,
                                                                                                                                                     transactions of Life
                                                                                         Advisory
                                                                                                                                                     Sciences companies                                         from     the     Life
                                                                                                        Closing                                                                                                 Sciences sectors
    Arno Fuchs          Dr. Mathias              Sebastian           Alexander Kuhn                    Assistance
        CEO               Schott                  Sommer                 Analyst
                           Director               Associate
                                                                                        Term Sheet
                                                                                        Negotiation                        Venture Capital Report                                              IPO Report
                                                                                                                                                     analyses the latest                                        examines        recent
                                                                                                          IPO
                                                                                                        Execution                                    Venture       Capital                                      IPO trends in the
                                                                                                         Support                                     funding activities in                                      Life Sciences sector,
                                                                                           Life
 Dr. Alexandra Goll    Claus Schalper           Prof. Dr.             Enno Spillner                                                                  the Life Sciences                                          with a strong focus
                                                                                         Science
      Former          Co-Founder & former     Horst Domdey             CFO Evotec
   General Partner     CFO Pieris Pharma    Co-Founder of Medigene                      Advisory                                                     sector in Europe                                           on the comparison
    TVM Capital                              & board member BioM                          Board       (extract from
                                                                                                      service portfolio)                             and the US                                                 of European and US
                                                                                                                                                                                                                characteristics

                                                                                                                                                                                                                                     3
Executive Summary

The FCF Life
                                  FCF Life Sciences Venture Capital Monitor                                                Recipients
Sciences Venture
Capital Monitor is a     is a monthly published overview of biotechnology, pharmaceutical,      The FCF Life Sciences Venture Capital Monitor targets the following
monthly published        medical technology and healthcare technology companies,                recipients:
overview focusing on     displaying venture capital financing trends in the European life             ▪ Corporates / Executives  ▪ Venture capital investors
the venture capital      science industry                                                             ▪ Institutional investors  ▪ Family Offices / High-
financing                                                                                             ▪ Private equity investors     net-worth individuals
environment in the                                                                                                               ▪ Advisors
biotechnology,                                          Scope
pharmaceutical,
medical technology       The selection of companies is based on the following criteria:                                    Availability
and healthcare
technology               ▪ Focus on transactions with European headquartered life science       The FCF Life Sciences Venture Capital Monitor is available on FCF’s
segments, and can           companies and available deal volume                                 website at “https://www.fcf.de/de/research/life-science-research“
be used as a quick       ▪ Companies operating in the biotechnology, pharmaceutical,
reference for               medical technology, healthcare technology, services or other life                                  Data
investors, corporates       science related sectors
and professionals                                                                               All input data is provided by Pitchbook or GlobalData and is not
                         ▪ The therapeutics sector is further divided into the following        independently verified by FCF. Ratio and multiple calculations are
                            indications: Oncology, Cardiovascular, Central Nervous System,      driven based on the input data available. For additional information
                            Gastrointestinal,     Hematological,    Infectious   Diseases,      and disclaimer, please refer to the last page
More advanced,              Immunology, Metabolic, Ophthalmology, Rare Diseases,
detailed and / or           Respiratory, Diversified and Others
customized reports
are available upon
request                    To recommend colleagues or fellow investors to be added to the       If you have questions, comments or ideas, please do not hesitate
                             mailing list, kindly send an email with the respective contact                               to contact us
                                                       information

                                                                                                                                                                       4
Agenda

V E N T U R E C AP I TAL
T R AN S AC T I O N S

AUGUST 2020
European Venture Capital Transactions in Life Sciences
                                                               August 2020

                                                                                                                                                                                                                                                Deal  Total
                                                                                                                                                                                                                                              Volume Raised
Overview (YTD)                                                                                                       #   Date     Company            HQ Subsector      Vertical - Indication / Stage Company Description               Series (EURm) (EURm) Deal Synopsis

Cumulative Financing Volume (EURm)                                                                                                                                                                  Developer of monolithic
7,000                                                             6,104                                                                                                                             detectors and x-ray technology
                                                                                                                                                                       Monolithic Detectors /
                                                                                                                     1 31-08-20   G-ray              CHE MedTech                                    intended to make medical             A     26      26   The company raised CHF 28 million of Series A venture on August 31, 2020.
6,000                                                                                                                                                                  On market
                                                                                                                                                                                                    imaging solutions more precise
5,000                                                                                                                                                                                               and secure.
4,000
3,000
2,000                                                                                                                                                                                               Operator of a biotech company
                                                                                                2020                                                                                                                                                        The company raised EUR 4.5 million of Series A venture funding on August 31, 2020.
1,000                                                                                                                             Biodol                   Biotech /   Central Nervous System /     intended to develop an
                                                                                                2019                 2 31-08-20                      FRA                                                                                 A      5      5    The funds will be used to develop FLT3 inhibitors for the treatment of chronic and
     0                                                                                                                            Therapeutics             Pharma      Pre-clinic                   innovative treatment for chronic
                                                                                                                                                                                                                                                            neuropathic pain.
               Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec                                                                                                                                      pain.
                      Financing Volume (August 2020): EUR 300m

Subsectors                                               Indications1
                    Healthcare                                                                                                                                                                                                                              The company raised EUR 4.3 million of Series A venture funding on August 31, 2020,
                                                                                                                                                                       AI-based Real-World          Developer of an AI-based real-
                     Services                                                                                                                                                                                                                               putting the company's pre-money valuation at an estimated EUR 6.38 million. The
                                                                                                                     3 31-08-20   Semalytix          DEU HealthTech    Evidence Generation Tool /   world evidence generation tool       A      4      4
                                                                                                                                                                                                                                                            funds will be used to expand its business development with pharma companies and
                                                                                                                                                                       On market                    designed to ingest data.
HealthTech                                                                                              Immunology                                                                                                                                          the wider healthcare market.
                         3%
                                                         Others
                20%                                                    29%                 29%
                         EUR                                                     EUR

                      6,104m      55%       Biotech /                          3,348m                                                                                                               Manufacturer of on-demand
                                            Pharma                    4%                                                                                               Customized Prosthetic        customized prosthetic products                          The company raised EUR 430,000 of venture funding on August 31, 2020. The funds
                22%                                     Gastro-        5%                                            4 31-08-20   Anatomic Studios   SWE MedTech       Products /                   intended to empower and inspire      -
European Venture Capital Transactions in Life Sciences
                                                               August 2020

                                                                                                                                                                                                                                                 Deal  Total
                                                                                                                                                                                                                                               Volume Raised
Overview (YTD)                                                                                                       #   Date      Company        HQ Subsector       Vertical - Indication / Stage Company Description                  Series (EURm) (EURm) Deal Synopsis

Cumulative Financing Volume (EURm)                                                                                                                                                                                                                           The company raised GBP 9.73 million of Series A venture funding on August 20, 2020,
                                                                                                                                                                                                   Developer of a novel molecular
7,000                                                             6,104                                                                                                                                                                                      putting the company's pre-money valuation at GBP 16.06 million. The funding will be
                                                                                                                                                        Biotech /    Diagnostics /                 assay intended to broaden
6,000                                                                                                                9 20-08-20    Biofidelity    GBR                                                                                     A     11      12   used to accelerate the development and clinical validation of oncology panels for
                                                                                                                                                        Pharma       Developing                    access to the highest precision
                                                                                                                                                                                                                                                             treatment selection and patient monitoring in oncology, and to bring these assays
5,000                                                                                                                                                                                              testing to all patients.
                                                                                                                                                                                                                                                             rapidly to market through direct sale, partnering and collaboration.
4,000
3,000
2,000                                                                                                                                                                                              Provider of a medical research
                                                                                                2020                                                                 Medical Research Data                                                                   The company raised $12 million of Series A venture on August 19, 2020. The funding
1,000                                                                                                                                                                                              data platform intended to
                                                                                                2019                 10 19-08-20   Castor         NLD HealthTech     Platform /                                                           A     10      16   will be used by the company to build out its patient-facing technology, which includes
     0                                                                                                                                                                                             facilitate electronic data capture
                                                                                                                                                                     On market                                                                               video-enabled consent to remotely enroll patients in clinical trials.
               Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec                                                                                                                                     for medical research.
                      Financing Volume (August 2020): EUR 300m

Subsectors                                               Indications1
                    Healthcare                                                                                                                                                                     Developer of novel technology                             The company raised GBP 250,000 of venture funding on August 19, 2020. The funding
                     Services                                                                                                      Magnitude            Healthcare   Diagnostics /
                                                                                                                     11 19-08-20                  GBR                                              intended to discover and develop       -
European Venture Capital Transactions in Life Sciences
                                                               August 2020

                                                                                                                                                                                                                                                      Deal  Total
                                                                                                                                                                                                                                                    Volume Raised
Overview (YTD)                                                                                                       #   Date      Company              HQ Subsector       Vertical - Indication / Stage Company Description                 Series (EURm) (EURm) Deal Synopsis

Cumulative Financing Volume (EURm)
                                                                                                                                                                                                        Developer of a healthcare                                 The company raised EUR 8.2 million of venture funding on August 11, 2020. In
7,000                                                             6,104                                                                                                    Online Doctor Consultation
                                                                                                                                                              Healthcare                                platform intended to serve                                support of the transaction, the firm received debt financing in the form of a loan. The
6,000                                                                                                                17 11-08-20   Practio              GBR                Platform /                                                          -      8      8
                                                                                                                                                              Services                                  patients with the help of local                           funds will be used to accelerate the deployment in the UK and to enter the German
                                                                                                                                                                           On market
5,000                                                                                                                                                                                                   pharmacies.                                               market later this year with other countries to follow from 2021 onwards.
4,000
3,000
2,000
                                                                                                2020                                                                       Implant for Heart Valve      Developer of an implant                                   The company raised EUR 20 million of Series B venture funding on August 7, 2020.
1,000
                                                                                                2019                 18 07-08-20   InnovHeart           ITA MedTech        Dysfunction /                technology intended to minimally       B     20      20   The funds will be used to complete the first in human clinical evaluation of the
     0                                                                                                                                                                     On market                    replace the invasive mitral valve.                        company's unique system using a trans-apical approach.
               Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
                      Financing Volume (August 2020): EUR 300m

Subsectors                                               Indications1
                    Healthcare                                                                                                                                                                          Owner and operator of a                                   The company raised $13 million of Series A venture on August 7, 2020. The proceeds
                     Services                                                                                                                                 Biotech /    Infectious Diseases /        biotechnology company intended                            will support the development of the HTI immunogen as a therapeutic vaccine against
                                                                                                                     19 07-08-20   Aelix Therapeutics   ESP                                                                                    A     11      11
                                                                                                                                                              Pharma       Phase II                     to develop a therapeutic vaccine                          HIV infection up to the completion of a Phase 2 proof-of-concept efficacy trial in HIV-
HealthTech                                                                                              Immunology                                                                                      to help people with HIV.                                  infected individuals.
                         3%
                                                         Others
                20%                                                    29%                 29%
                         EUR                                                     EUR

                      6,104m      55%       Biotech /                          3,348m
                                            Pharma                    4%                                                                                                                                Developer of an e-healthcare
                22%                                                                                                                                                                                                                                               The company raised EUR 6.1 million of Series A venture funding on August 6, 2020.
                                                        Gastro-        5%                                                                                                  E-Healthcare Application /   application intended to provide
MedTech                                                 intestinal                        21%                        20 06-08-20   Elma                 ESP HealthTech                                                                         A      6      7    The funding raised will be used to boost product development, the business growth
                                                                               12%                                                                                         On market                    quicker doctor-patient
                                                         Infectious                                                                                                                                                                                               and expansion of the team to put to the service user.
                                                                                                  Oncology                                                                                              communication in Spain.
                                                         Diseases
                                                                      Central
                                                                      Nervous
                                                                      System

                                                                                                                                                                                                                                                                  The company raised EUR 66 million of Series A venture funding on August 6, 2020,
Top Company Origins                                      Top Investor Origins                                                                                 Biotech /    Oncology /
                                                                                                                                                                                                        Developer of T cell receptors                             putting the company's pre-money valuation at an estimated EUR 2.53 billion. The
                                                                                                                     21 06-08-20   T-Knife              DEU                                             intended for T cell therapy of         A     66     132   funds will be used by the company to advance at least four programs into the clinic,
                                                                                                                                                              Pharma       Pre-clinic
                                                                                                                                                                                                        cancer.                                                   ramping-up preclinical work for additional selected proprietary pipeline candidates and
      Others                                                                                                                                                                                                                                                      discovering TCRs against novel targets.
                                                          Others
                 24%             27%                                  31%                  29%
                         EUR                                                     EUR

               9%
                      6,104m                                                   6,104m
                                                                                                                                                                                                      Developer of a genome-analysis                              The company raised EUR 2.4 million of Pre-Series A venture funding on August 6,
                                 15%                                                       11%                                                                             Genome-Analysis Platform /
                 12%
                                                                          9%                                         22 06-08-20   Made of Genes        ESP HealthTech                                platform designed to understand          A      2      3    2020. The funds will be used to launch and promote its VITAL and HEALTH lines, as
                                                                                                                                                                           On market
                         13%                                                   10% 10%                                                                                                                human genomes.                                              well as the a new product.

Top 5 Deals                                             Top 5 Investors
                                  Deal                                                           # of      Deal                                                                                         Developer of a portable
 # Company               HQ      Volume   Series         # Investor                  HQ         Deals     Volume2
                                                                                                                                                                           Portable Wheelchair
                                                                                                                                                                                                        wheelchair technology intended
                                                                                                                     23 06-08-20   Mooevo               ESP MedTech        Technology /                                                        -
European Venture Capital Transactions in Life Sciences
                                                               August 2020

                                                                                                                                                                                                                                     Deal  Total
                                                                                                                                                                                                                                   Volume Raised
Overview (YTD)                                                                                                       #   Date      Company    HQ Subsector   Vertical - Indication / Stage Company Description              Series (EURm) (EURm) Deal Synopsis

Cumulative Financing Volume (EURm)
7,000                                                             6,104                                                                                                                 Developer of a health tech
                                                                                                                                                             Audio Gadget /                                                                      The company raised GBP 1.32 million of venture funding on August 5, 2020, putting
6,000                                                                                                                25 05-08-20   Kokoon     GBR MedTech                               gadget designed to offer sleep        -      1      6
                                                                                                                                                             On market                                                                           the company's pre-money valuation at GBP 9.17 million.
                                                                                                                                                                                        and relaxation using audio.
5,000
4,000
3,000
2,000                                                                                                                                                                                   Developer of real-time and
                                                                                                2020                                                                                    accurate intra-uterine monitoring                        The company raised GBP 3.9 million of Series A venture on August 3, 2020. The funds
1,000                                                                                                                                                        Monitoring Device /
                                                                                                2019                 26 03-08-20   VivoPlex   GBR MedTech                               device built for optimization of      A      4      6    will be used for a clinical feasibility study and to gain a European CE mark for its first
     0                                                                                                                                                       Developing
                                                                                                                                                                                        fertility treatment and uterine                          product, which will enable them to sell their product in the market.
               Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec                                                                                                                          health.
                      Financing Volume (August 2020): EUR 300m

Subsectors                                               Indications1
                    Healthcare
                     Services

HealthTech                                                                                              Immunology
                         3%
                                                         Others
                20%                                                    29%                 29%
                         EUR                                                     EUR

                      6,104m      55%       Biotech /                          3,348m
                                            Pharma                    4%
                22%                                     Gastro-        5%
MedTech                                                 intestinal                        21%
                                                                               12%
                                                         Infectious
                                                                                                  Oncology
                                                         Diseases
                                                                      Central
                                                                      Nervous
                                                                      System

Top Company Origins                                      Top Investor Origins

      Others
                                                          Others
                 24%             27%                                  31%                  29%
                         EUR                                                     EUR

               9%
                      6,104m                                                   6,104m
                                 15%                                      9%               11%
                 12%
                         13%                                                   10% 10%

Top 5 Deals                                             Top 5 Investors
                                  Deal                                                           # of      Deal
 # Company               HQ      Volume   Series         # Investor                  HQ         Deals     Volume2

 1 2Eyes Vision                   600       B            1 Bpifrance                             24          71
     CureVac
 2                                560       G            2 Venture Kick                          20          2
     (NAS: CVAC)
 3 LumiraDx                       278       C                Mercia Asset
                                                         3                                       11          7
                                                             Management
   Arvelle
 4                                205       A              High-Tech
   Therapeutics                                          4                                       10          13
                                                           Gründerfonds
   Oxford
 5 Nanopore                       186       -            5 Novo Holdings                         9           66
   Technologies

Source: PitchBook as of 15.09.2020; FCF Equity Research; GlobalData
Note: All volumes in EURm; financing rounds without deal values are excluded                                                                                                                                                                                                                                                             9
1Only includes biotechnology and pharmaceutical deals; 2 Proportional attribution of deal values to investors participating in a transaction (transaction volume / # investors by financing round)
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