FCF Fox Corporate Finance GmbH - FCF Life Science Venture Capital Monitor May 2019 05/2019
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FCF Fox Corporate Finance GmbH FCF Life Science Venture Capital Monitor May 2019 Antibody Part of FCF Life Science Research Series „Thinking Strategic Finance in Life Science”
Agenda F C F L i f e S c i e nc e O v e r v i ew 2
FCF Life Sciences Life Science Overview Advisory Services Facts and Figures Focus on Biotechnology, MedTech and HealthTech Over Over Life Science Life Science Management Team of 100 years EUR 2bn FCF advises innovative companies on arranging, structuring and placing Advisory in aggregated Life Science Presentation ~10 equity and debt transactions in a holistic financing strategy approach. Board Life Science transaction Integrated based in Munich Together with its FCF Life Science Advisory Board, FCF Life Science experience volume1 Financial provides valuable support on the strategic positioning of its clients Modeling Post- Over 4 Access to Strategic Financing Advisory Transaction 80 Leading regularly Support > 1000 completed Life EIB advisor published Life international FCF advises with its dedicated Life Science team on the following Investor Science in Europe Science investors transaction types: Screening transactions1 reports 1 comprising Professionals and Advisory Board Investor / IB Venture Venture Roadshow Life Science Research Series Capital Debt Due Diligence FCF Life Science FCF Life Science Support Venture Capital Monitor Public Equity Monitor Equity & Debt is a monthly is the most detailed Life Science Team Fundraising published overview analysis of Financing of venture capital European publicly Strategy listed companies, transactions of Life Advisory Science companies from the Life Closing Science sectors Assistance Arno Fuchs Dr. Mathias Schott Sebastian Sommer Colin Saß CEO Director Analyst Analyst Term Sheet FCF Life Science FCF Life Science Negotiation Venture Capital Report IPO Report analyses the latest examines recent IPO Execution Venture Capital IPO trends in the Support funding activities in Life Science sector, Life Science the Life Science with a strong focus Dr. Alexandra Goll Prof. Dr. Claus Schalper Dr. Holger Bengs Advisory Former Horst Domdey Co-Founder & former Founder & CEO sector in Europe on the comparison Board (extract from General Partner Co-Founder of Medigene AG CFO Pieris Pharma BCNP Consultants and the US of European and US TVM Capital service portfolio) board member of BioM AG characteristics 3
Executive Summary The FCF Life Science Venture Capital FCF Life Science Venture Capital Monitor Recipients Monitor is a monthly is a monthly published overview of biotechnology, pharmaceutical, The FCF Life Science Venture Capital Monitor targets the following published overview medical technology and healthcare technology companies, recipients: focusing on the displaying venture capital financing trends in the European life ▪ Corporates / Executives ▪ Venture capital investors venture capital science industry ▪ Institutional investors ▪ Family Offices / High- financing environment ▪ Private equity investors net-worth individuals in the biotechnology, ▪ Advisors Scope pharmaceutical, medical technology The selection of companies is based on the following criteria: Availability and healthcare technology segments, ▪ Sole focus on transactions with obtainable deal volume and The FCF Life Science Venture Capital Monitor is available on FCF’s and can be used as a involving European headquartered life science companies website at “https://www.fcf.de/de/research/life-science-research“ quick reference for ▪ Companies operating in the biotechnology, pharmaceutical, investors, corporates medical technology, healthcare technology, services or other life Data and professionals science related sectors All input data is provided by Pitchbook or GlobalData and is not ▪ The therapeutics sector is further divided into the following independently verified by FCF. Ratio and multiple calculations are indications: Oncology, Cardiovascular, Central Nervous System, More advanced, driven based on the input data available. For additional information Gastrointestinal, Hematological, Infectious Diseases, and disclaimer, please refer to the last page detailed and / or Immunology, Metabolic, Ophthalmology, Rare Diseases, customized reports Respiratory, Diversified and Others. are available upon request To recommend colleagues or fellow investors to be added to the If you have questions, comments or ideas, please do not hesitate mailing list, kindly send an email with the respective contact to contact us information 4
Agenda V e n t ur e C a p i t a l T r a n s a c t i ons May 2019 5
European Venture Capital Transactions in Life Sciences May 2019 Vertical - Deal Total Indication / Volume Raised Overview (YTD) # Date Company HQ Subsector Stage Company Description Series (EURm) (EURm) Investors Deal Synopsis Cumulative Financing Volume (EURm) Central Developer of medical therapeutics The company raised $3.9 million of venture funding from Seventure 5,000 Nervous intended for the treatment of 4,156 1 28/05/2019 Biotech - 3 35 Seventure Partners Partners on May 28, 2019. The funds will be used to accelerate the System / Central Nervous System (CNS) 4,000 company's next growth phase. Phase II diseases and cancer. 3,000 1,737 2,000 The company raised GBP 500,000 of venture funding in a deal led by 1,000 Manufacturer of medical devices Maven Capital Partners on May 28, 2019. GMC Fund and Chinese 2019 Back Care / GMC Fund, Maven Capital 2018 2 28/05/2019 MedTech designed to offer back care -
European Venture Capital Transactions in Life Sciences May 2019 Vertical - Deal Total Indication / Volume Raised Overview (YTD) # Date Company HQ Subsector Stage Company Description Series (EURm) (EURm) Investors Deal Synopsis Cumulative Financing Volume (EURm) Developer a fish-skin Wound The company raised $1.61 million of venture funding from undisclosed 5,000 transplantation technology 4,156 9 17/05/2019 MedTech Treatment / - 1 4 na investors on May 23, 2018. The amount was originally raised in the form designed to facilitate healing 4,000 On market of convertible debt and subsequently converted to equity. through tissue regeneration. 3,000 1,737 Bpifrance, Idinvest The company raised $38.5 million of Series B venture funding in a deal 2,000 Partners, Illumina led by Life Sciences Partners on May 16, 2019. Merck Ventures, 1,000 Developer of enzymatic DNA Ventures, Kurma Partners, Idinvest Partners, Sofinnova Partners, Kurma Partners, Illumina 2019 Immunology / 2018 10 16/05/2019 Biotech synthesis platform intended to B 33 47 Life Sciences Partners, Ventures, M Ventures and Bpifrance also participated in the round. The On market 0 facilitate genome scale synthesis. Merck Ventures, funds will be used to accelerate the development of the company's first Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec MVentures, Sofinnova products based on its industry-leading enzymatic technology for de novo Financing Volume (May 2019): EUR 357m Partners synthesis of nucleic acids. Subsectors Indications1 The company raised $4.5 million of Series B venture funding from Innovation Fund, SambrInvest and Jean-Pierre Delwart on May 16, Healthcare Patient Developer of patient Innovation Fund, Jean 2019. Jean Stephenne also participated in the round. The company Services Central Nervous 11 16/05/2019 HealthTech Analysis / characterization tools intended to B 4 4 Stephenne, Jean-Pierre Pharmaceuticals Systems intends to use the funds to advance commercialization of Placebell©™, Developing improve patients condition. Delwart, SambrInvest its product that limits the effect of the placebo response on clinical trials, 3% Biotechnology Others and to expand its product portfolio. 12% 20% EUR 42% 40% EUR 17% 1,737m 1,067m 16% Oncology Developer of coupling fluid Cofounders Capital, Sarsia The company raised NOK 10 million of venture funding from Sintef MedTech Diagnostic / Seed, Sintef 12 16/05/2019 MedTech technology designed to identify - 1 2 Energiforskning, Cofounders Capital and Sarsia Seed on May 16, 2019. 4% 7% 13% Developing Energiforskning, 26% tumor remnants. Sparebank 1 Smn Invest also participated in the round. Sparebank 1 Smn Invest HealthTech Metabolic Immunology Disorders Infectious Diseases The company raised EUR 80 million of Series E venture funding in a Developer of an medical Enern, Goldman Sachs deal led by One Peak Partners and Goldman Sachs Private Capital appointment scheduling platform Top Company Origins Top Investor Origins 13 14/05/2019 HealthTech Platform / designed to improve patient flow E 80 128 Private Capital Investing Investing Group on May 14, 2019. Piton Capital, Enern and other On market Group, One Peak Partners, undisclosed investors also participated in the round. The funds will be and help digitise healthcare Piton Capital used continue the company's push in core European and Latin Others practices. Others American markets, purse R&D activities and expand their team. 24% 23% 22% 27% EUR EUR The company raised $18 million of Series B venture funding in a deal 5% 1,737m 6% 1,737m Imaging / Provider of imaging software Capricorn Venture led by Forestay Capital on May 14, 2019. Optum Ventures and 7% 21% 14 14/05/2019 HealthTech platform intended to be used for B 15 18 Partners, Forestay Capital, 23% 6% On market Capricorn Venture Partners also participated in the round. The funds will multiple sclerosis (MS). Optum Ventures 18% 18% be used by the company to continue to develop its technology. The company raised EUR 7.1 million of Series A venture funding on Top 5 Deals Top 5 Investors Developer of stem cells intended Aquitaine Science Central May 13, 2019. The funds will be used by the company to proceeds its to secure cell production and Transfert, AQUITI Gestion, Deal Deal # of Nervous transition for their technology to cGMP standards by 2021 and to # Company HQ Volume Series # Investor HQ Volume2 Deals 15 13/05/2019 Biotech quality, fasten clinical A 7 8 Galia Gestion, Irdi Soridec System / develop proprietary and collaborative cell therapy research programs in Arvelle development and facilitate market Gestion, XAnge Private 1 155 A 1 Bpifrance 63 9 Pre-clinic a wide array of indications with the objective of a first-in-man clinical trial Therapeutics access. Equity in 2024. Life Sciences 2 Doctolib 150 - 2 50 4 Partners The company raised GBP 2.4 million of Series A venture funding from Andera 3 Ynsect 110 C 3 48 4 Care Developer of an integrated Cambridge Angels, IQ IQ Capital Partners, Longwall Ventures and Cambridge Angels on May Partners Tracking healthcare technology intended to Capital Partners, Longwall 9, 2019, putting the pre-money valuation at GBP 2.8 million. Martlet, Idinvest 16 09/05/2019 HealthTech A 3 4 4 ZnanyLekarz 80 E 4 39 4 platform / improve patient outcomes and Ventures, Martlet, Peter Sherry Coutu and Peter Cowley also participated in the round. The Partners Developing health system performance. Cowley, Sherry Coutu funds will be used by the company to support the development of a drug Sophia BRV Capital + digital approach and to treat and manage major health conditions. 5 66 E 5 31 1 Genetics Management Source: PitchBook as of 04.06.2019; FCF Equity Research; GlobalData 7 Note: All volumes in EURm; financing rounds without deal values are excluded 1Only includes biotechnology and pharmaceutical deals; 2 Proportional attribution of deal values to investors participating in a transaction (transaction volume / # investors by financing round)
European Venture Capital Transactions in Life Sciences May 2019 Vertical - Deal Total Indication / Volume Raised Overview (YTD) # Date Company HQ Subsector Stage Company Description Series (EURm) (EURm) Investors Deal Synopsis Cumulative Financing Volume (EURm) Provider of e-medicine platform The company raised EUR 2 million of venture funding in a deal led by Communicati 5,000 intended to serve medico-social Crédit Mutuel Arkéa on May 9, 2019. Other undisclosed investors also 4,156 17 09/05/2019 HealthTech on / - 2 2 Crédit Mutuel Arkéa establishments and home care participated in this round. The funds will be used by the company to 4,000 On market services. expand its business. 3,000 1,737 2,000 The company raised $12 million of Series A venture funding in a deal Provider of a medical health led by Optum Ventures and Qiming Venture Partners on March 28, 1,000 testing platform designed to 2019 Diagnostic / Optum Ventures, Qiming 2018. Other undisclosed investors also participated in the round. The 2018 18 08/05/2019 HealthTech connect customers and global A 10 11 On market Venture Partners funds will be used to continue expanding to the U.S., grow the full 0 laboratories for personal health clinical support team and further invest in the company's technology Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec testing. platform that links customers to laboratories. Financing Volume (May 2019): EUR 357m Beyond Next Ventures, CI:Z Subsectors Indications1 Holdings, CMBCC Co-High Medical Investment Fund, Cyril Janssen, The company raised EUR 39.7 million of Series D venture funding on Healthcare Genetic Developer of stem cell therapy Itochu, Korea Investment Partners, May 7, 2019. The funds will be used by the company for its Services Central Nervous 19 07/05/2019 Biotech Disorders / intended to treat liver diseases D 40 104 Marc Speeckaert, Medipal Holdings, Pharmaceuticals Systems Mirae Asset Capital, Mitsui Global manufacturing scale-up, preclinical programs and overall operations of Phase II easily. Investment, Olivier van der Rest, the company and the group. 3% Shibuya, Shinsei Capital Partners, 12% Biotechnology Others 20% Six Snow, Sosei EUR 42% 40% EUR BioGeneration Ventures, 17% Capricorn Venture Partners, The company raised EUR 30 million of Series A venture funding on May 1,737m 1,067m 16% Oncology Musculoskele Developer of a drug discovery Fund+, Perceptive Advisors, 7, 2019. The funds will be used by the company to accelerate its MedTech 20 07/05/2019 Biotech tal Disorders / technology designed to address A 30 37 PMV, Qbic Fund, University ConfoBodyTM-enabled drug discovery activities and to develop its 26% 4% 7% 13% Discovery unmet medical needs. of Michigan Endowment, V- pipeline of GPCR modulating compounds to produce drug candidates Bio Ventures, VIB, for clinical trials. HealthTech Metabolic Immunology Wellington Partners Disorders Infectious Diseases The company raised EUR 8 million of venture funding in a deal led by Banco de Sabadell, Caixa Caixa Capital Risc and Sabadell Asabys Health Innovation Investments Developer of a virtual reality Capital Risc, Carlos on May 7, 2019. Banco de Sabadell and Carlos Gallardo also Top Company Origins Top Investor Origins 21 07/05/2019 HealthTech VR / platform designed to bring value - 8 9 Gallardo, Sabadell Asabys participated in the round. The funds will be used to complete the VR On market to mental health treatment. Health Innovation platform that can be used to treat anxiety disorders, stress management, Others Investments depression, attention problems such as ADHD, autistic spectrum and Others psychotic disorders. 24% 23% 22% 27% The company raised CHF 9.5 million of Series A venture funding in a EUR EUR deal led by Panakes Partners on May 6, 2019. btov Partners, Brabantse Brabantse Ontwikkelings 5% 1,737m 6% 1,737m Imaging / Developer of medical imaging Maatschappij, btov Ontwikkelings Maatschappij, Sioux Group and other undisclosed 7% 21% 22 06/05/2019 MedTech devices intended to improve A 8 13 existing investors also participated in the round. The funds will be used 23% 6% On market Partners, Panakes cancer treatment care. to commercialize the patented Histolog system, notably the recently CE 18% 18% Partners, Sioux Group mark Histolog Scanner v2, for enabling precise tumor removal at first surgery. Top 5 Deals Top 5 Investors Manufacturer of high quality growth factors designed to use in The company graduated from Babraham Bioscience Technologies on Deal Deal # of Immunology / Babraham Bioscience # Company HQ Volume Series # Investor HQ Volume2 Deals 23 01/05/2019 Biotech stem cell science and -
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