ITALY'S COVID CONUNDRUM - ARCA SGR SPA

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ITALY'S COVID CONUNDRUM - ARCA SGR SPA
Marzo 2020

                                                                    ITALY’S COVID CONUNDRUM

                                                                 Europe has, for the time being, become the focal point of coronavirus
                                                                 contagion. Its epicentre is Italy (Figure 1), which now accounts for a
                                                                 quarter of the world’s active cases.

                                                                 Italy’s mortality rate has risen to double the global average. While
                                                                 country-to-country discrepancies can easily arise in the early stages
                                                                 of a pandemic, this gap doesn’t make intuitive sense. Over time the
                                                                 disease should have a similar effect on all populations.

                                                                 To square the arithmetic, twice the mortality rate would suggest Italy’s
                                                                 infections are understated by half. But in fact, it turns out that its infection
                                                                 rate (per million of population) is also close to double that of any other
                                                                 major country (Figure 2). Something else is going on.

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ITALY'S COVID CONUNDRUM - ARCA SGR SPA
Other countries’ experience might provide some clues.

                        China began to report a steady increase in case
                        resolution (deaths plus recoveries, as a share of
                        reported infections) from end-January. By 18th
                        February its remaining active cases had peaked
                        (Figure 3).

                        Italy’s epidemiological progression started around three
                        weeks later. Lagging the Chinese data by 23 days, we
                        can see that Italy’s resolution rate matched China’s for
                        the first couple of weeks of its epidemic. But over the
                        most recent 10 days Italian resolutions have slipped
                        behind that pace, improving only marginally, with new
                        infections rising far faster than recoveries (Figure 4).

                        Now, it may be that the difference in recovery rates is
                        partly definitional. Across the board, richer countries
                        seem to have exhibited lower recovery rates — or
                        more extended recovery times — than poorer ones.
                        It may well be the case that in poorer countries, which
                        generally have less hospital capacity available per
                        capita, a patient being discharged from hospital to
                        convalesce at home — because they are no longer
                        considered to be in mortal danger — is classified as a
                        “recovery”. In a richer country that patient may remain
                        under hospital supervision for quite a while longer.

                        The age test

                       Another country which appears to have got a grip on the
                       virus is South Korea (see Figure 1). It took a different
                       approach to China, avoided draconian restrictions on
                       the population’s movement. Of course there were
    some special factors in Korea — including a concentrated cluster of early
    infections — but their approach was based more on widespread testing
    for the disease with quarantining of those infected. To date Korea has
    performed 287,000 tests, eight times as many as the US and Japan
    combined, despite a population one-ninth the size. Italy has taken that
    message on board, with more than 100,000 tests performed.

    But the Korea paradigm is pertinent in another way. We know that
    coronavirus is most dangerous for the elderly, with at least half of all
    fatalities globally occurring in the over-70s. So an obvious analytical
    starting point is to look at the weight of this cohort in each country. Korea

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is at the younger end of the spectrum and has a low
                        mortality rate of around 1% while Italy is at the older
                        end with a mortality rate of closer to 8%. So far, so
                        intuitive.

                        But looking at a wider spread of countries shows
                        that population age explains little of the variation in
                        observed rates of mortality (Figure 5).

                        We need to dig deeper. Unsurprisingly, Korea has
                        also seen infections biased towards the younger end
                        of the population. Only 9% of Korea’s infections have
                        been among the over-70s, broadly in line with this
                        cohort’s 10.6% share of the overall population.

                        This is where the contrast with Italy could not be
                        starker. While over-70s account for 17.5% of Italy’s
                        population, a staggering 38.5% of infections have
                        been among this cohort (Figure 6).

                        If the prevalence of infections in the over- 70s goes
                        a long way in explaining why Italy’s mortality rate is
                        so high, it begs the question as to why so many of
                        the elderly are getting infected. A cultural of tactile
                        social greetings, coupled with a tendency to live
                        in multigenerational dwellings, may be admirable
                        hallmarks of Mediterranean conviviality in normal
                        times. But in current circumstances going home to
                        hug Nonna is a no-no.

                        Health system needs acute care

                        If Italians are becoming infected faster than almost
                        anyone else, and within the overall population the
                        elderly are succumbing disproportionately, it stands to
                        reason that the country’s hospital services are under
                        intense pressure.

    In China, around a fifth of the first 45,000 coronavirus infections were
    graded either “serious” or “critical”. While, given the age bias, this
    fraction is likely to be higher in Italy, as a rich country it should also have
    a stronger healthcare system.

    What counts in these circumstances is the availability of intensive care
    unit (ICU) beds. Normal occupancy of standard hospital beds varies by
    country from 65-85%, varying by season, with higher occupancy during

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ITALY'S COVID CONUNDRUM - ARCA SGR SPA
the winter months. Occupancy of ICU beds is a
                                                                                             fairly stable 80% in the UK all year round whereas in
                                                                                             the US, where there are many more beds per 100K
                                                                                             population, it averages 68%.

                                                                                             This means there’s 20-30% “spare capacity” to meet
                                                                                             Covid-19 related admissions. While the situation can
                                                                                             change rapidly, for most countries that’s sufficient at
                                                                                             the moment (Figure 7).

                                                                                             The exception, unsurprisingly, is Italy. Assuming 79%
                                                                                             normal occupancy, its current level of 1,800+ serious/
                                                                                             critical coronavirus cases has used up almost all the
                                                                                             spare ICU beds available. Anecdotal reports confirm
                                                                                             that the health system there is close to overload.

                                                               Once those in a serious condition are turned away from brim-full hospitals
                                                               and left to be treated at home, it is likely that fatalities will be exacerbated.
                                                               Indeed, given Italy’s exceptionally-high mortality rate of 7.7%, this may
                                                               already be happening.

                                                               For whom the bells tolls

                                                               Most conclusions about coronavirus are necessarily speculative at this
                                                               stage. All we know is that the disease spreads rapidly and kills the
                                                               vulnerable fast.

                                                               Italy’s grim experience is a warning to all other countries to test
                                                               aggressively, to implement quarantine measures, to shore up our health
                                                               systems, and to protect the elderly. A vaccine may ultimately be found,
                                                               but this will likely take more time than we have.

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ITALY'S COVID CONUNDRUM - ARCA SGR SPA
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