COVID, Cancer Care, and Cancer Research - National Coalition for Cancer Survivorship Cancer Policy Roundtable
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COVID, Cancer Care, and
Cancer Research
National Coalition for Cancer Survivorship
Cancer Policy Roundtable
Norman E. Sharpless, M.D.
April 22, 2021 @NCIDirector
@TheNCI
Today
• 50th Anniversary of the National Cancer Act
• Cancer Moonshot
• NCI Appropriations & Paylines
• COVID-19 Impacts and Activities
• NCI Activities in Cancer Survivorship
• Equity and Inclusion
2
“The President and I stand with you. This
is the fight of our lives, and we will never
stop working to end this disease. And
together, I know that we're going to go
farther than ever before.”
Dr. Jill Biden
Virtual Visit to NCI
February 3, 2021
I’d love to be the President to preside
over the end of cancer as we know it.
These are the folks in the House and
Senate who would love to preside over
cancer —the end of cancer as we know it.
President Joe Biden
Bipartisan Meeting on
Cancer, Oval Office
March 3, 2021
3
What would it mean to end
cancer as we know it?
What would it take?
4
National Cancer Act of 1971 50th Anniversary 1971- 2021
Cancer MoonshotSM
6
Select Cancer Moonshot efforts in survivorship
Initiative Grants / Projects Principal Investigator
Improving the Management of A Randomized Trial of a Mobile Health and Nina S. Kadan-Lottick,
symPtoms during and Social Media Physical Activity Intervention Jason A. Mendoza
following Cancer Treatment Among Adolescent and Young Adult
(IMPACT) Childhood Cancer Survivors
Improving Outcomes for Self-Management to Optimize Survivorship Virginia Chih-Yi Sun
Pediatric, Adolescent and Care and Outcomes in Lung and Colorectal
Young Adult (AYA) Cancer Cancer
Survivors
Optimizing the Management The EPICS (Engaging Primary Care In Erin Elizabeth Hahn
and Outcomes for Cancer Cancer Survivorship) Study: A Randomized
Survivors Transitioning to Trial of Novel Models of Care for Cancer
Follow-up Care Survivors
Optimizing Functional Outcomes of Older Supriya G. Mohile, Michelle
Survivors After Chemotherapy C. Janelsins, Karen M.
Mustian
7
NCI Appropriations 21st Century Cures Act - orange
FY 2015 – 2021 (in millions) Childhood Cancer Initiative - green
$6,560
$7,000 $6,440
$5,965 $6,144 $195
$195
$50 $50
$6,000 $5,689 $400
$300 $6,195 $6,315
$300
$5,665 $5,744
$5,000 $5,389
$5,215
$4,950
$4,000
+ $306M
COVID-19
$3,000 serology
(April 2020)
$2,000
$1,000
$0
FY 2015 FY 2016 FY 2017 FY 2018 FY 2019 FY 2020 FY 2021
8
NCI Paylines for FY 2021
GRANT TYPE PAYLINE
R01 Grants for 15 by 25
Established and New 11th Percentile
Investigators goal
R01 Grants for Early-
Stage Investigators (ESIs)
16th Percentile 15th
percentile
R21 Exploratory Grants 9th Percentile
R01 payline
Non-competing grants will be funded at 100%.
by 2025
9
NCI COVID-19 activities
F O U N D AT I O N A L CLINICAL & SUPPORT FOR CANCER
SEROLOGY T R A N S L AT I O N A L RESEARCH AND CARE
A M I D T H E PA N D E M I C
SEROLOGY
Serological Sciences NCI COVID-19 in Cancer
Sero-protection Studies:
Network (SeroNet) • Mount Sinai, University of Arizona Patients Study (NCCAPS)
• NIH All of Us Flexibilities for grantees
• 8 Centers of • NCI SEER + Health Verity
Excellence Clinical trials adaptations
COVID-19 Seroprevalence Studies Modeling to predict long-term
• 13 Research Projects
Hub (SeroHub) cancer outcomes
• 4 Capacity Building
Centers Antibody test performance
evaluation, with FDA ADDITIONAL COVID-19
• FNL Serology Lab &
Network Coordinating Standard reference serum RESEARCH
Center • Excess Mortality Study
Clinical trials for COVID-19
therapeutics • Digital Health
• Tocilizumab Solutions (with NIBIB)
• CD24Fc • ACTIV (trans-NIH)
10NCI COVID-19 in Cancer Patients Study (NCCAPS)
900+ Special emphasis on
minority,
Enrolled
patients will
TRIAL SITES underserved and be followed
ACTIVATED
IN
rural communities for 2 years
1051
50 Now open to pediatric
patients Aims to enroll
PATIENTS
ENROLLED
STATES 2,000 patients
+ DC, PUERTO Launched May 21 across 1,000
RICO, AND Conception to Launch in sites in U.S.
CANADA 6 weeks
As of April 19, 2021. 11COVID-19 & Cancer
time.com AUGUST 28, 2020 12Impact of COVID-19 Pandemic on Cancer Screening in the US
Colorectal Cancer Screening Lung Cancer Screening
(Colonoscopy and FIT) (LDCT)
Cancer Screening During the Coronavirus Disease-2019 Pandemic: A
Perspective From the National Cancer Institute’s PROSPR Consortium.
Gastroenterology, Volume 160, Issue 4, 999 - 1002 13Impact of COVID-19 Pandemic on Cancer Screening in the US
Cervical Cancer Screening Breast Cancer Screening
(Pap Smear) (Mammography)
Cancer Screening During the Coronavirus Disease-2019 Pandemic: A
Perspective From the National Cancer Institute’s PROSPR
Consortium. Gastroenterology, Volume 160, Issue 4, 999 - 1002 14Centers on Telehealth Research for Cancer-Related
Care – Goals:
Leverage the P50 mechanism to:
1. Create national centers for advancing
RFA cancer-related telehealth research in a
CA-21-029 rapidly changing environment
2. Establish a robust evidence base for
patient-centered, sustainable telehealth
models of cancer care delivery
3. Foster the development, evaluation, and
dissemination of evidence-based models of
cancer-focused telehealth
15Emily S. Tonorezos, MD, MPH
Director
Office of Cancer Survivorship
Division of Cancer Control and
Population Sciences
16STAR Act Implementation
Identifying best
New survivorship New biobanking
practices in
research opportunities projects
survivorship care
• Improving Outcomes for • Several Children’s • Partnership with the Agency
Pediatric, Adolescent and Oncology Group projects, for Healthcare Research and
Young Adult Cancer including the Rare Tumor Quality (AHRQ)
Survivors: 7 U01 awards Populations Biobank
• 1st of 3 evidence reviews
• Research to Reduce
• Projects in collaboration with published in March 2021
Morbidity and Improve Care
the Childhood Cancer focused on Disparities and
for Pediatric, and Adolescent
Survivor Study Barriers to Pediatric Cancer
and Young Adult (AYA)
Survivorship Care
Cancer Survivors
• Specimen collection efforts in
• 2 reviews in progress, to be
collaboration with the published later this year,
Childhood Cancer Data
focusing on models of care
Initiative and transitions in care
174/23/21
NCI Equity and Inclusion Program
EQUITY Chair Mark Alexander Montse Garcia- Donna Siegle
Ned Sharpless Andrea Apolo Closas Dinah Singer
COUNCIL
Nelvis Castro Anne Lubenow Sanya Springfield
Vice Chair Bob Croyle Ji Luo
Paulette Gray
WORKING GROUP 1 WORKING GROUP 2 WORKING GROUP 3 WORKING GROUP 4 WORKING GROUP 5
Enhancing Ensuring Diversity of Promoting an Systematic Tracking Communications
Research to Thought and Inclusive and and Evaluation of and Outreach for
Address Cancer Background in the Equitable Community Equity Activities Equity Activities
Health Disparities Cancer Research at NCI
Workforce
CO-CHAIRS CO-CHAIRS CO-CHAIRS CO-CHAIRS CO-CHAIRS
Jim Doroshow LeeAnn Bailey Shannon Bell Michelle Bennett Peter Garrett
Worta McCaskill- Susan McCarthy Paige Green Doug Lowy Angela Jones
Stevens Glenn Merlino Satish Gopal Anita Linde
Tiffany Wallace
19Discussion
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