COVID-19 VACCINATION IN MANITOBA TECHNICAL BRIEFING - March 3, 2021
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VACCINE DELIVERY MODEL UPDATES Winnipeg Brandon Thompson SUPERSITES In larger centres, supersites 6,945 1,473 350 allow for rapid and large-scale DOSES ADMINISTERED DOSES ADMINISTERED DOSES ADMINISTERED IN LAST WEEK vaccination for increased IN LAST WEEK IN LAST WEEK speed and efficiency. 39,649 5,279 350 TOTAL DOSES TOTAL DOSES TOTAL DOSES ADMINISTERED ADMINISTERED ADMINISTERED 777 165 116 AVG. DAILY DOSES AVG. DAILY DOSES AVG. DAILY DOSES 55 27 14 3 EST. DAILY STAFF (FTE) EST. DAILY STAFF (FTE) EST. DAILY STAFF (FTE)
VACCINE DELIVERY MODEL UPDATES FOCUSED • FITs will visit 120 congregate living facilities this week and administer about 4,800 residents IMMUNIZATION • More than 7,800 second-doses in personal care home immunization TEAMS (FITs) campaign FITs visit facilities to deliver vaccines where people live. • All regional health authorities have scheduled prioritized congregate living sites this week. 4
WORKFORCE RECRUITMENT DAILY OPERATIONAL SCHEDULE Overall, staffing is down due to lack of vaccine RBC CONVENTION CENTRE KEYSTONE CENTRE FIT TEAM - Winnipeg 1060 Doses 256 Doses 535 Doses 71 31 12 TOTAL STAFF (FTE) TOTAL STAFF (FTE) TOTAL STAFF (FTE) 31 Immunizers (FTE) 12 Immunizers (FTE) 12 Immunizers (FTE) CURRENT WORKFORCE 2,224 165 • • 1,647 immunizers 20 clinic managers STAFF • 27 clinical leads As of March 1, 2021 this week • 426 navigators • 104 observers 5
COVID-19 DOSE DELIVERY SCHEDULE Doses Received & Projected 60.0 K 50.0 K 40.0 K 30.0 K 20.0 K 10.0 K 0.0 K 14-Dec- 21-Dec- 28-Dec- 15-Mar- 22-Mar- 29-Mar- 4-Jan-21 11-Jan-21 18-Jan-21 25-Jan-21 1-Feb-21 8-Feb-21 15-Feb-21 22-Feb-21 1-Mar-21 8-Mar-21 5-Apr-21 12-Apr-21 19-Apr-21 26-Apr-21 20 20 20 21 21 21 Moderna Doses 0.0 K 7.3 K 0.0 K 0.0 K 7.4 K 0.0 K 0.0 K 8.1 K 0.0 K 0.0 K 6.1 K 0.0 K 20.5 K 0.0 K 40.6 K 0.0 K 0.0 K 0.0 K 0.0 K 0.0 K Pfizer Doses 2.3 K 11.7 K 1.2 K 7.0 K 9.4 K 9.4 K 0.0 K 2.3 K 3.5 K 15.2 K 17.6 K 16.4 K 16.4 K 14.0 K 14.0 K 14.0 K 0.0 K 0.0 K 0.0 K 0.0 K Total 2.3 K 19.0 K 1.2 K 7.0 K 16.8 K 9.4 K 0.0 K 10.4 K 3.5 K 15.2 K 23.7 K 16.4 K 36.9 K 14.0 K 54.6 K 14.0 K 0.0 K 0.0 K 0.0 K 0.0 K As of March 2, 2021
SUPERSITE Closing Stock Balance - Supersites INVENTORY 12,000 16,000 MANAGEMENT 14,000 10,000 12,000 8,000 10,000 Projected for the next 30 days 6,000 8,000 6,000 4,000 4,000 2,000 2,000 0 - 2021-02-28 2021-03-01 2021-03-02 2021-03-03 2021-03-04 2021-03-05 2021-03-06 2021-03-07 2021-03-08 2021-03-09 2021-03-10 2021-03-11 2021-03-12 2021-03-13 2021-03-14 2021-03-15 2021-03-16 2021-03-17 2021-03-18 2021-03-19 2021-03-20 2021-03-21 2021-03-22 2021-03-23 2021-03-24 2021-03-25 2021-03-26 2021-03-27 2021-03-28 RBC Supersite Keystone Supersite Thompson Supersite Total Projections as of March 2. Each rise in doses represents a scheduled delivery. 7
DOSE ADMINISTRATION PROJECTION • Based on current Daily Doses Administered - Projection Does not include doses allocated to First Nations supply projections, 4,000 140,000 we estimate an 3,500 120,000 3,000 average of 2,277 2,500 100,000 injections per day in 2,000 80,000 March, subject to 60,000 1,500 current vaccine 40,000 1,000 supply forecasts. 500 20,000 - - Supersites FIT (Pfizer for WRHA, Moderna for other RHAs) Total Cumulative Projected as of March 2 8
LOW-RANGE SCENARIO Based on Pfizer and Moderna vaccines. Allocation details on AstraZeneca have not been provided to Manitoba yet. Projected as of March 2 9
HIGH-RANGE SCENARIO Based on Pfizer, Moderna, AstraZeneca and other vaccines that have not yet been approved Projected as of March 2 10
DELIVERING 1.5 MILLION DOSES
SECOND Daily • Manitoba continues to report Site / Approach Maximum QUARTER Capacity Daily Maximum Capacity Supersites EXPANSION • This shows how many doses (RBC, Backup Site, Keystone, Thompson, Vaxport) 6,499 Building from Manitoba's could be delivered on any small, deliberate and safe given day in Manitoba if we Distributed Model 5,000 starting point to deliver the had adequate supply. largest immunization Focused 500 campaign in provincial Immunization Teams • This will be updated as history new facilities and staff are Pop-up Clinics 500 added to increase capacity. Current Daily Maximum Capacity 12,499 TARGET CAPACITY Q2 20,000 12
CONTINUED Protecting Manitobans, Building Capacity PROGRESS • First general • Morden supersite to open mid- population immunizations on March March 1 • PCH 2nd dose campaign complete • Regular expansions of eligibility criteria • Congregate living facility 1st dose campaign underway • Vaxport pilot project underway • Selkirk supersite opens March 8, appointments being booked now 13
VACCINE TECHNOLOGY
COVID-19 Vaccines Approved vaccines: More vaccines expected to be approved Q2+: Multiple vaccines in various stages • Pfizer-BioNTech approved Dec. 9, 2020 • Johnson & Johnson* Each approved vaccine, • Moderna approved Dec. • Novavax particularly those using different 23, 2020 • Sanofi and GSK technologies, will have different • AstraZeneca/Covishield • Medicago indications for use approved Feb. 26, 2021 *FDA approved Johnson & Johnson one-shot vaccine, Janssen, on Feb. 27, 2021. 15
Vaccine Supply Supply to Canada is Expected to Increase • Supply is expected to increase • Over 70,000 doses of mRNA exponentially in Q2 as more vaccine (Pfizer and Moderna) vaccines are approved and administered in Manitoba to date currently-approved vaccines ramp up production • Supply of AstraZeneca expected by mid-March 16
COVID-19 Vaccine Agreements in Canada Supplier / Vaccine Technology Platform Doses Status AstraZeneca Viral vector 20 million Approved Feb. 2021 Moderna mRNA 44 million Approved Dec. 2020 Pifzer-BioNTech mRNA Up to 76 million Approved Dec. 2020 Johnson & Johnson Viral vector Up to 38 million Under review; submitted to Health Canada Nov. 11, 2020 Medicago Plant-based Up to 76 million Phase III; anticipated to seek licensure Q3, 2021. Novavax Subunit protein Up to 76 million Under review; submitted to Health Canada Jan. 29, 2021 Sanofi and GlaxoSmithKline Subunit protein Up to 72 million Phase II; anticipated to seek licensure Q4, 2021. Does not include provincially-procured vaccines 17
Vaccinology • The three vaccines currently • The COVID-19 vaccines use RNA authorized for use in Canada or DNA that provide the (Pfizer –Biontech mRNA, Moderna instructions for our immune mRNA, and Astra Zeneca DNA) system to manufacture the protein protect us from COVID-19 that causes our immune system to infection using a different produce protective antibodies and approach than other, more familiar immune cells. vaccines. • For example: The measles vaccine fuses a weakened live virus that causes our immune system to produce protective antibodies and immune system cells. Flu vaccines use inactivated virus to do the same. 18
mRNA Vaccines Pfizer-BioNTech and Moderna • Storage: ultra-frozen (70˚C) for Pfizer and frozen (-20˚C) for Moderna • Authorized ages: 16+ for Pfizer and 18+ for Moderna • Schedule: 2 doses, 3-4 weeks apart. 19
mRNA Vaccine Effectiveness •Both mRNA vaccines were shown to •Emerging ‘real world’ evidence from be safe and effective in preventing lab the UK, Scotland and Israel suggests Pfizer-BioNTech and Moderna confirmed COVID-19 infection after that one dose of mRNA vaccine is 70- two doses (with effectiveness around 80% effective in preventing lab 94-95%). confirmed COVID-19 infection and also significantly reduced •However, significant protection hospitalization and death. started about 12-14 days after the first dose and may be above 90% in the •Effectiveness against variants of clinical trials. concern is evolving. 20
Viral Vector (DNA) Vaccines • Storage: Routine at 2˚C to 8˚C AstraZeneca • Authorized age: 18+ • Schedule: 2 doses, 4-12 weeks apart (12 weeks preferred) 21
Viral Vector (DNA) Vaccine •Although the initial clinical trial results •Real world data from the United showed the AstraZeneca vaccine to Kingdom in those 70+ are showing Effectiveness be moderately effective (around 60%), single dose effectiveness >70% and a subsequent analysis of the data significant reduction in hospitalization AstraZeneca shows that longer intervals between and death. dose 1 and dose 2 (12 weeks) resulted in effectiveness >80%. •Data on effectiveness against variants of concern is evolving. 22
Ongoing Evaluation • Ongoing clinical trials • Provincial table reviews any reports of AEFI and collaborates All vaccines continue to be • Ongoing real-world effectiveness with national tables monitored for safety and studies effectiveness after they are • Vaccine safety is monitored more authorized for use • Federal adverse events following closely than any other medical immunization (AEFI) system intervention 23
Which Vaccine Should I Get? • If you are eligible to be immunized, • Being immunized with one type of the answer is simple: The first vaccine now will not prevent you vaccine available to you. from getting another type of COVID-19 vaccine in the future, • Locations where you can get when supplies are greater vaccines will expand, and there will be more types of vaccines • Get the facts on COVID-19 vaccine available over time. from reliable sources • But this is key: All vaccines • Vaccines are safe, effective and approved for use are effective in are a life-saving intervention preventing you from getting COVID-19, and in reducing the seriousness of your symptoms 24
COVID-19 VACCINATION IN MANITOBA QUESTIONS? Media are invited to provide feedback on future tech briefings or specific areas of interest to lenore.kowalchuk@gov.mb.ca
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