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For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 Feb 8 COVID-19 Situation Report 375 Centre for Infectious Disease Epidemiology and Research (CIDER)
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 i. Background In December, China notified the World Health Organization (WHO) of several cases of human respiratory illness, which appeared to be linked to an open seafood and livestock market in the city of Wuhan. The infecting agent has since been identified as a novel coronavirus, previously known as 2019-nCoV and now called SAR-CoV-2; The new name of the disease has also been termed COVID-19, as of 11th February 2020. Although the virus is presumed zoonotic in origin, person-to-person spread is evident. Screening of travellers, travel bans and quarantine measures are being implemented in many countries. Despite these precautions, it is anticipated that more cases will be seen both inside China and internationally. The WHO declared the outbreak of COVID-19 constitutes a Public Health Emergency of International Concern on 30 January. On 11 March, 2020, WHO declared the coronavirus outbreak a pandemic as the global death toll rose above 4,600 and the number of confirmed cases topped 125,000. This report aims to update Global Risk Assessment, Global Epidemiology, Quarantine Orders, Travel Ban/Advisory by countries, WHO’s and CDC’s Guidance and Protocols and Scientific publication on a daily basis. New updates in the tables are bolded. 1|Page Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 ii. Global Risk Assessment Table 1. Risk assessment of COVID-19 by WHO regions (Updated as of 8 Feb 2021, 1500H SGT) Transmissibilit Severity of Availability of Treatment/ Overall Environmental Risk y Disease Vaccination# Risk Global (n=197 countries) High Moderate High Limited Globally, 188 (95.4%) countries (excluding Based on CDC Case The number of countries that have territories*) have reported the outbreak. data, median fatality rate commenced mass vaccination in each R0 is estimated is currently region are as follows: Combined WPRO Using an incidence >20 cases/100,000 to be 5.8 (95% at 2.18% and SEARO (9 countries), EURO (37 people over the past 14-days as cut-off for CI 4.4–7.7), globally. countries), EMRO (7 countries), a surge in cases, the number of countries but the Most cases Americas (10 countries), and Africa (2 reporting a surge in cases in each region estimated present as countries).& are as follows: Combined WPRO and effective flu-like SEARO (6 countries), reproduction illness. International clinical trials published on EURO (48 countries), number in 171 2 September confirm that cheap, widely EMRO (13 countries), Americas (29 countries available steroid drugs can help countries), and Africa (16 countries). ranged from seriously ill patients survive Covid-19. 0.021 to 2.9.$ The World Health Organization issued Only 4 (2%) countries/territories have no new treatment guidance, strongly reported restrictions on inbound arrivals, recommending steroids to treat while 144 (78%) countries/territories have severely and critically ill patients, but High partially reopened their borders – require not to those with mild disease. [4] arrivals to produce a negative COVID-19 test result and/or undergo self-quarantine Researchers have found all regimens of upon arrival. 53 (29%) anticoagulants to be far superior to no countries/territories are totally closed to anticoagulants in COVID-19 patients. international arrivals. [1] More specifically, patients on both a “therapeutic” or full dose and those on On October 7, the Centers for Disease a “prophylactic” or lower dose, showed Control and Prevention (CDC) confirmed about a 50% higher chance of survival airborne transmission of SARS-CoV-2. [2] and roughly a 30% lower chance of intubation, than those not on The U.S. CDC has revised its guidance on anticoagulants. It was observed that COVID-19 quarantine period from 14 days therapeutic and prophylactic to 7-10 days, based one's test results and subcutaneous low-molecular weight symptoms. Individuals without symptoms heparin and therapeutic oral apixaban only need quarantine for 10 days without may lead to better results. [3] testing; those tested negative can quarantine for 7 days. [14] Western Pacific Region and South-East Asia Region (n=41 countries) Moderate Moderate Moderate High 33 (80.5%) countries have reported As of February Case Vaccine coverage information was outbreaks; but only 6 (14.6%) are 3, the fatality rate available for 4 countries as of 6 reporting a surge in cases. estimated is 1.56%. February 2021. Coverage for: i) at least 1 dose was at
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 Highest incidence over the past 14 days ranged from were reported from Indonesia, Japan, 0.15-2.9.$ Malaysia, Maldives and Sri Lanka and highest case numbers were reported from India, Indonesia, Japan, Malaysia and Philippines. At least 20 countries have closed their borders, 22 countries have opened their borders partially conditionally, and none are allowing free travel. European Region (n=53 countries) High Moderate High High 52 (98.1%) countries have reported with As of February Case Vaccine coverage information was outbreaks; 48 (90.6%) countries are 3, the fatality rate available for 31 countries as of 6 reporting a surge in cases. estimated is 2.20%. February 2021. Coverage for i) at least 1 effective dose was at
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 Region of the Americas (n=35 countries) High Moderate High High 35 (100%) countries have reported with As of February Case Vaccine coverage information was outbreak; 29 (82.9%) countries are 3, the fatality rate available for 8 countries as of 6 reporting a surge in cases. estimated is 2.32%. February 2021. Coverage for: i) at least effective 1 dose was at
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 ranged from Ethiopia has approved the use of Highest incidence over the past 14 days 0.021-2.1.$ Dexamethasone treatment for seriously were reported from Botswana, Cabo ill COVID-19 patients. [13] Verde, Nambia, Seychelles and South Africa and highest case numbers were reported from Ghana, Mozambique, Nigeria, South Africa and Zambia. At least 9 countries have closed their borders, 38 countries have opened their borders partially conditionally, and no country is allowing free travel. *Only WHO member states are included. 30 territories that have reported cases (with the exception of Palestine) are excluded from the tabulation of total countries affected/imported/local cases and case fatality rate. Refer to WHO situation reports or table 4 for information. # Ongoing clinical trials of vaccines and treatment are summarised in section X % This is by no means an exhaustive list of lockdowns imposed globally. Tally is subjected to publication bias whereby certain countries may receive less media attention and hence, coverage on their travel bans implemented. $ https://epiforecasts.io/covid/posts/global/ ^ Differences between R0 and effective R can be found here https://www.coronavirustoday.com/r-number-refers- either-basic-or-effective-reproduction-number & https://ourworldindata.org/covid-vaccinations; High vaccine coverage defined as >70% population with full vaccination € https://covid19.trackvaccines.org/vaccines/ 5|Page Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 iii. Global Epidemiology Table 2. Summary of COVID-19 cases & fatalities globally (Updated as of 8 Feb 2021, 1500H SGT) Case- No. of Total Cases Case- Fatality Countries/ Total Global Outside Total Fatality Rate (%) R0 Territories Cases Mainland Deaths Rate (%) [outside with Cases China [overall] China] 5.8 (95% CI 4.4– 219 106,712,241 106,622,535 2,327,942 2.18% 2.18% 7.7)^ ^Based on early release as of 10th April, 2020: https://wwwnc.cdc.gov/eid/article/26/7/20-0282_article Table 3. Comparison with other viruses Virus Incubation Period (Days) Case Fatality Rate (%) R0 Median = 5.1$ SARS-CoV-2 2.18 5.8 (95% CI 4.4–7.7) ^ (2-14) or up to 24* SARS-CoV 2-7 9.6 2.0
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 Figure 2. Growth Factor excluding mainland China Figure 3. Growth Factor of Novel Coronavirus Daily Deaths (Mainland China + Other Countries) Growth Factor = every day’s cases/cases on previous day. A growth factor above 1 indicates an increase, whereas one between 0 and 1 is a sign of decline, with the quantity eventually becoming zero. A growth factor below 1 (or above 1 but trending downward) is a positive sign, whereas a growth factor constantly above 1 is the sign of exponential growth. Source: https://www.worldometers.info/coronavirus/coronavirus-cases/ 7|Page Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 Case Breakdown by Countries Live update of COVID-19 global cases can be found at https://storymaps.arcgis.com/stories/a1746ada9bff48c09ef76e5a788b5910 Table 4. Breakdown of COVID-19 confirmed cases and deaths (Updated as of 8 Feb 2021, 1500 SGT) Total Country Total Cases Change Change Total Recovered Region Deaths 1 USA 27,611,403 +91767 474,933 +1405 17,354,388 Americas 2 India 10,838,843 +11673 155,114 +86 10,533,076 SEARO 3 Brazil 9,524,640 +26845 231,561 +492 8,397,187 Americas 4 Russia 3,983,197 +31964 77,068 +839 3,472,091 EURO 5 UK 3,945,680 +15845 112,465 +373 1,915,629 EURO 6 France 3,337,048 +19715 78,965 +171 232,977 EURO 7 Spain 2,971,914 0 61,386 0 N/A EURO 8 Italy 2,636,738 +11640 91,273 +270 2,118,441 EURO 9 Turkey 2,531,456 +6670 26,797 +112 2,420,706 EURO 10 Germany 2,291,441 +6442 62,128 +130 2,041,300 EURO 11 Colombia 2,157,216 +6009 55,993 +300 2,027,333 Americas 12 Argentina 1,980,347 +3658 49,171 +61 1,778,965 Americas 13 Mexico 1,932,145 +6065 166,200 +414 1,490,077 Americas 14 Poland 1,550,255 +4725 39,087 +93 1,307,161 EURO 15 South Africa 1,476,135 +2435 46,290 +110 1,360,204 Africa 16 Iran 1,466,435 +7065 58,469 +57 1,253,554 EMRO 17 Ukraine 1,246,990 +5511 23,644 +128 1,075,743 EURO 18 Peru 1,186,698 +6220 42,308 +187 1,094,573 Americas 19 Indonesia 1,157,837 +10827 31,556 +163 949,990 SEARO 20 Czechia 1,037,405 +7293 17,333 +204 922,223 EURO 21 Netherlands 1,005,760 +3934 14,403 +48 N/A EURO 22 Canada 804,260 +3203 20,767 +65 738,766 Americas 23 Portugal 765,414 +3508 14,158 +204 606,166 EURO 24 Chile 751,886 +3804 18,974 +79 710,029 Americas 25 Romania 745,318 +1975 18,881 +72 691,377 EURO 26 Belgium 725,610 +4178 21,389 +94 49,911 EURO 27 Israel 692,101 +6518 5,121 +50 619,329 EURO 28 Iraq 628,550 +1134 13,120 +9 600,193 EMRO 29 Sweden 588,062 0 12,115 0 N/A EURO 30 Pakistan 555,511 +2383 12,026 +112 511,502 EMRO 31 Bangladesh 538,062 +292 8,205 +15 483,372 SEARO 32 Philippines 537,310 +1789 11,179 +69 499,798 WPRO 33 Switzerland 531,873 0 9,613 +7 317,600 EURO 34 Morocco 475,355 +389 8,394 +13 454,504 EMRO 35 Austria 423,839 +1317 8,012 +18 402,053 EURO 36 Serbia 407,881 +1529 4,126 +14 31,536 EURO 37 Japan 403,435 +2080 6,338 +95 362,231 WPRO 8|Page Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 38 Hungary 376,495 +1370 13,090 +64 279,763 EURO 39 Saudi Arabia 370,278 +317 6,402 +5 361,515 EMRO 40 Jordan 335,154 +1299 4,379 +10 320,335 EMRO 41 Panama 327,091 +627 5,480 +25 292,302 Americas 42 UAE 326,495 +3093 921 +7 305,759 EMRO 43 Lebanon 319,917 +2081 3,616 +54 206,523 EMRO 44 Nepal 271,925 +119 2,038 +3 268,072 SEARO 45 Slovakia 263,326 +1552 5,199 +64 241,686 EURO 46 Georgia 262,228 +608 3,298 +29 254,350 EURO 47 Belarus 258,691 +1732 1,783 +10 247,177 EURO 48 Ecuador 258,282 +1167 15,012 +8 220,398 Americas 49 Malaysia 242,452 +3731 872 +15 190,339 WPRO 50 Croatia 235,402 +276 5,169 +25 227,485 EURO 51 Azerbaijan 231,154 +132 3,158 +2 225,246 EURO 52 Bolivia 227,967 +839 10,796 +43 168,040 Americas 53 Bulgaria 223,734 +182 9,331 +20 193,251 EURO 54 Dominican Republic 223,398 +1250 2,831 +30 167,214 Americas 55 Tunisia 217,086 +910 7,214 +52 173,862 EMRO 56 Ireland 203,568 +1020 3,686 +12 23,364 EURO 57 Denmark 201,621 +435 2,216 +1 192,695 EURO 58 Costa Rica 196,438 0 2,672 0 156,181 Americas 59 Kazakhstan 196,115 +2149 2,540 0 176,744 EURO 60 Lithuania 186,770 +492 2,937 +10 138,108 EURO 61 Slovenia 173,702 +501 3,623 +11 154,321 EURO 62 Kuwait 170,998 +962 966 +2 161,538 EMRO 63 Egypt 169,640 +534 9,651 +47 132,375 EMRO 64 Armenia 168,177 +240 3,123 +9 159,876 EURO 65 Moldova 164,569 +326 3,543 +13 153,785 EURO 66 Greece 163,946 +733 5,972 +21 147,254 EURO 67 Guatemala 163,137 +200 5,884 +30 149,342 Americas 68 Palestine 162,601 +572 1,881 +11 152,579 EMRO 69 Honduras 154,568 +1315 3,721 +27 61,817 Americas 70 Qatar 154,098 +408 250 0 146,910 EMRO 71 Ethiopia 142,338 +885 2,148 +3 125,619 Africa 72 Myanmar 141,304 0 3,168 0 127,229 SEARO 73 Nigeria 139,748 +506 1,667 +20 113,525 Africa 74 Paraguay 138,118 +515 2,826 +19 114,258 Americas 75 Oman 135,674 +633 1,534 +2 127,698 EMRO 76 Venezuela 130,116 +473 1,233 +5 122,081 Americas 77 Libya 124,026 +1132 1,953 +17 104,539 EMRO 78 Bosnia and Herzegovina 123,434 0 4,775 0 97,128 EURO 79 Algeria 109,088 +459 2,914 +5 74,692 Africa 80 Bahrain 107,329 +616 380 +1 101,168 EMRO 81 Kenya 101,819 +129 1,779 +3 84,361 Africa 9|Page Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 82 North Macedonia 94,798 +199 2,924 +8 83,999 EURO 83 China 89,706 +14 4,636 0 83,952 WPRO 84 Albania 85,336 +1124 1,460 +14 51,444 EURO 85 Kyrgyzstan 85,113 +121 1,431 +8 81,714 EURO 86 S. Korea 81,185 +289 1,474 +3 71,218 WPRO 87 Uzbekistan 79,162 +117 621 0 77,564 EURO 88 Latvia 71,800 +480 1,339 +12 59,897 EURO 89 Ghana 70,768 +722 457 +8 63,959 Africa 90 Sri Lanka 69,348 +772 356 +5 63,401 SEARO 91 Montenegro 65,227 +488 838 +2 56,731 EURO 92 Norway 64,772 +119 582 0 57,004 EURO 93 Zambia 62,633 +1206 853 +14 54,835 Africa 94 Singapore 59,699 +24 29 0 59,433 WPRO 95 El Salvador 56,237 0 1,692 +19 50,431 Americas 96 Afghanistan 55,359 +24 2,413 +3 48,041 EMRO 97 Luxembourg 51,848 +159 593 +1 48,421 EURO 98 Estonia 47,928 +416 461 +5 37,785 EURO 99 Finland 47,616 +354 688 0 31,000 EURO 100 Uruguay 45,311 +499 490 +9 38,976 Americas 101 Mozambique 44,600 +488 460 +9 27,162 Africa 102 Uganda 39,848 +27 327 0 14,349 Africa 103 Namibia 34,973 +129 375 +4 33,454 Africa 104 Zimbabwe 34,552 +65 1,326 +10 28,551 Africa 105 Cuba 32,831 +820 238 +5 26,739 Americas 106 Cyprus 31,759 +115 212 +1 2,057 EURO 107 Cameroon 31,394 0 474 0 29,501 Africa 108 Ivory Coast 29,825 +258 162 0 27,981 Africa 109 Australia 28,857 +7 909 0 26,089 WPRO 110 Senegal 28,760 +271 682 +7 23,559 Africa 111 Sudan 27,631 +131 1,835 +4 21,986 EMRO 112 Malawi 27,195 +320 856 +19 11,596 Africa 113 DRC 23,599 +114 681 +2 15,113 Africa 114 Thailand 23,557 +423 79 0 17,410 SEARO 115 Botswana 23,503 0 163 0 19,574 Africa 116 Angola 20,086 +24 475 0 18,540 Africa 117 Madagascar 19,360 +295 285 +4 18,490 Africa 118 Malta 18,676 +100 282 +3 16,053 EURO 119 French Polynesia 18,185 0 133 0 4,842 Non 120 Jamaica 17,085 +244 358 +1 12,271 Americas 121 Mauritania 16,807 +15 426 +1 16,005 Africa 122 Maldives 16,783 +127 55 +1 14,604 SEARO 123 Rwanda 16,451 +114 220 +3 12,342 Africa 124 French Guiana 16,296 0 79 0 9,995 Non 125 Eswatini 16,204 +23 604 0 11,614 Non 10 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 126 Guinea 14,687 +22 84 0 14,345 Africa 127 Syria 14,477 +69 952 +5 8,134 EMRO 128 Cabo Verde 14,423 +43 135 0 13,723 Africa 129 Tajikistan 13,308 0 90 0 13,218 EURO 130 Belize 12,037 0 306 0 11,479 Americas 131 Haiti 11,806 0 246 0 9,156 Americas 132 Gabon 11,457 0 71 0 10,797 Africa 133 Burkina Faso 11,285 +58 134 0 10,129 Africa 134 Hong Kong 10,636 +27 186 0 9,887 WPRO 135 Réunion 10,507 0 47 0 9,769 Non 136 Andorra 10,251 +45 106 +1 9,533 EURO 137 Mayotte 9,546 0 63 0 2,964 Non 138 Lesotho 9,380 0 183 0 2,706 Africa 139 Guadeloupe 9,226 0 155 0 2,242 Non 140 Suriname 8,671 +21 161 +1 8,020 Americas 141 Bahamas 8,256 0 176 0 6,819 Americas 142 Mali 8,176 +16 338 0 6,066 Africa 143 Congo 8,060 0 122 0 5,846 Africa 144 Guyana 7,982 +43 180 0 6,966 Americas 145 Trinidad and Tobago 7,616 +4 135 0 7,266 Americas 146 Aruba 7,223 +21 62 0 6,834 Non 147 Martinique 6,484 0 45 0 98 Non 148 Nicaragua 6,299 0 170 0 4,225 Americas 149 Iceland 6,021 0 29 0 5,959 EURO 150 Djibouti 5,947 +6 63 0 5,852 EMRO 151 Equatorial Guinea 5,578 0 86 0 5,358 Africa 152 Togo 5,483 +47 80 +1 4,550 Africa 153 CAR 4,989 0 63 0 4,885 Africa 154 Somalia 4,862 +8 134 0 3,720 EMRO 155 Curaçao 4,613 +8 21 0 4,535 Non 156 Niger 4,612 +14 165 0 3,970 Africa 157 South Sudan 4,355 0 66 0 3,663 Africa 158 Gambia 4,237 0 134 0 3,886 Africa 159 Benin 4,193 0 55 0 3,563 Africa 160 Gibraltar 4,182 +5 83 +3 3,944 Non 161 Channel Islands 3,896 +11 83 0 3,405 Non 162 Sierra Leone 3,785 +13 79 0 2,466 Africa 163 Chad 3,497 +24 125 0 2,895 Africa 164 San Marino 3,127 0 69 0 2,795 EURO 165 Comoros 3,086 0 108 0 2,334 Africa 166 Guinea-Bissau 2,780 +8 46 0 2,427 Africa 167 Liechtenstein 2,523 +5 52 0 2,424 Non 168 Eritrea 2,326 0 7 0 1,719 Africa 169 New Zealand 2,320 0 25 0 2,229 WPRO 11 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 170 Yemen 2,127 0 615 0 1,428 EMRO 171 Mongolia 2,073 +50 2 0 1,493 WPRO 172 Vietnam 2,001 +16 35 0 1,472 WPRO 173 Liberia 1,956 0 84 0 1,770 Africa 174 Sint Maarten 1,928 0 27 0 1,780 Non 175 Saint Lucia 1,813 0 18 0 875 Americas 176 Burundi 1,723 +6 3 0 773 Africa 177 Barbados 1,709 +33 18 0 1,400 Americas 178 Turks and Caicos 1,695 +41 9 0 1,319 Non 179 Monaco 1,655 +8 19 0 1,380 EURO 180 Seychelles 1,513 +9 7 +1 1,158 Africa 181 Sao Tome and Principe 1,351 0 18 0 1,060 Africa 182 St. Vincent Grenadines 1,269 +67 4 +1 409 Americas 183 Saint Martin 1,234 0 12 0 1,050 Non 184 Taiwan 927 +3 9 0 844 WPRO 185 Papua New Guinea 895 +4 9 0 846 WPRO 186 Bhutan 861 0 1 0 854 SEARO 187 Diamond Princess 712 0 13 0 699 NA 188 Bermuda 692 0 12 0 670 Non 189 Faeroe Islands 656 +1 1 0 652 Non 190 Mauritius 584 0 10 0 540 Africa 191 Tanzania 509 0 21 0 183 Africa 192 Cambodia 474 0 0 0 454 WPRO 193 Isle of Man 434 0 25 0 405 Non 194 Cayman Islands 405 0 2 0 368 Non 195 Caribbean Netherlands 360 0 3 0 244 Non 196 St. Barth 360 0 1 0 247 Non 197 Antigua and Barbuda 299 +11 7 0 187 Americas 198 Brunei 181 0 3 0 173 WPRO 199 Grenada 148 0 1 0 146 Americas 200 Dominica 121 0 0 0 110 Americas 201 British Virgin Islands 114 0 1 0 95 Non 202 Timor-Leste 80 0 0 0 61 SEARO 203 Fiji 56 0 2 0 53 WPRO 204 New Caledonia 49 0 0 0 47 Non 205 Macao 48 0 0 0 46 WPRO 206 Falkland Islands 45 0 0 0 36 Non 207 Laos 45 0 0 0 41 WPRO 208 Saint Kitts and Nevis 40 0 0 0 36 Americas 209 Greenland 30 0 0 0 30 Non 210 Vatican City 27 0 0 0 15 Non 211 Saint Pierre Miquelon 24 0 0 0 16 Non 212 Montserrat 17 +2 1 0 13 Non 213 Anguilla 17 0 0 0 15 Non 12 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 214 Solomon Islands 17 0 0 0 10 WPRO 215 Western Sahara 10 0 1 0 8 Non 216 MS Zaandam 9 0 2 0 7 NA 217 Wallis and Futuna 5 0 0 0 4 Non 218 Marshall Islands 4 0 0 0 4 WPRO 219 Samoa 2 0 0 0 2 WPRO 220 Micronesia 1 0 0 0 1 WPRO 221 Vanuatu 1 0 0 0 1 WPRO Total 106,712,241 +368928 2,327,942 +7492 78,328,502 Figure 4. Areas with reported confirmed cases of COVID-19 (25 January – 31 January 2021) Source: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports 13 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 Table 5. COVID-19 cases and deaths reported by provinces in China (Updated as of 8 Feb 2021, 1500H SGT) Existing Change from Total Change from Area Active previous day Diagnosed Deaths previous day Recovered Cases (Active cases) Cases (Deaths) Heilongjiang 350 -37 1,609 13 0 1,246 Jilin 234 -13 573 3 0 336 Hebei 192 0 1,316 7 0 1,117 Shanghai 125 -3 1,739 7 0 1,607 Beijing 49 -2 1,046 9 0 988 Guangdong 48 +4 2,144 8 0 2,088 Shaanxi 22 -1 542 3 0 517 Fujian 15 0 545 1 0 529 Tianjin 15 0 346 3 0 328 Jiangsu 14 0 701 0 0 687 Hunan 11 0 1,033 4 0 1,018 Zhejiang 10 0 1,316 1 0 1,305 Sichuan 10 0 873 3 0 860 Shanxi 10 -1 239 0 0 229 Liaoning 7 -2 402 2 0 393 Inner Mongolia 5 -2 366 1 0 360 Shandong 1 0 866 7 0 858 Guangxi 1 0 267 2 0 264 Yunnan 1 0 231 2 0 228 Hubei 0 0 68,150 4,512 0 63,638 Henan 0 -1 1,303 22 -1 1,281 Anhui 0 0 994 6 0 988 Xinjiang 0 0 980 3 0 977 Jiangxi 0 0 935 1 0 934 Chongqing 0 0 591 6 0 585 Gansu 0 0 187 2 0 185 Hainan 0 0 171 6 0 165 Guizhou 0 0 147 2 0 145 Ningxia 0 0 75 0 0 75 Qinghai 0 0 18 0 0 18 Tibet 0 0 1 0 0 1 Source: https://ncov.dxy.cn/ncovh5/view/pneumonia 14 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 iv. Travel Bans/Advisories & Quarantine Orders [1] Austria- Borders control with all neighbouring countries will be tightened and non-essential travel should be avoided. [2] Greece- Travel restriction will be extended until 22 Feb. Travelers will continue to submit passenger locator form and negative covid-19 test result taken within 72 hours before arrival and undergo a 7-days quarantine. UK arrivals will be required to take PCR on the 7th day of the quarantine. Non-EU residents except for 10 countries will be banned from entering the country. Flights from Turkey will remain banned. v. Lockdowns [1] Cyprus- On 8 Feb, Cyprus will move to the second phase of the COVID-19 measures relaxation. Elementary schools and third grade of high schools will reopen. All shops, shopping centers and malls will also reopen. Museums and other archaeological sites will reopen with measures in place. Churches and other religious site will reopen with a limit of 50 churchgoers. Home visits will be allowed for four people. Some sports activities will resume and training of 5 athletes will be allowed. All employees returning to work are required to have negative rapid test which will be performed weekly. Theatres and cinemas will reopen but limited to 50 people. [2] Greece- Non-essential travel restriction for domestic flights have been extended until 15 Feb. Essential travel for health and business reason, family reunification and returning of permanent resident will be allowed. [3] Malaysia- Restrictions for Chinese New Year reunion dinner will be eased. Limit of 15 family members from different household living within 10km from each other will be allowed to dine together. Family members will not be allowed to travel across state or district boundaries. Religious activities within house of worship will be allowed on 11, 12 and 19 Feb but limited to 30 people and with measures in place. Prayers will be limited to 30 min followed by 30 minute of cleaning and sanitation before the next session. [4] UAE- From 7 Feb, Abu Dhabi will ban parties and gathering and close cinema. Marriage ceremonies and family gathering will be limited to 10 people while funerals and mourning services will allow 20 people. Capacity limit of 40% for malls, 50% for gyms, private beaches and swimming pools. 60% for restaurants, coffee shops, hotels, public beaches and parks, 45% for taxi and 75% for buses will be imposed. vi. Military Surveillance COVID-19 in British Troops in Kenya [1] The British Army has reported four new cases in the British troop who are in Nanyuki, Kenya for Exercise Askari Storm. The cases were identified while undergoing 6 days isolation upon arrival. 320 military personnel have been placed under isolation rules with half being quarantine in tents. More than 1,000 troops were being fed on rations as orders were issued for cookhouse to close and local staff not to report to work until the outbreak is under control. 15 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 vii. WHO Guidance & Other Protocols No update was published by the WHO on 7 February 2021. viii. CDC Guidance & Protocols US CDC The following updates were published by the US CDC on 7 February 2021. Large Gatherings Available at: https://www.cdc.gov/coronavirus/2019-ncov/your-health/large-gatherings.html Small Gatherings Available at: https://www.cdc.gov/coronavirus/2019-ncov/daily-life-coping/holidays/small- gatherings.html EU CDC No update was published by the EU CDC on 7 February 2021. ix. Vaccines/Therapeutics Development Noteworthy reports are included to inform main developments of COVID-19 pharmaceutics. Past updates are available from situation report 211 onwards. A global map and registry of trials is also visualised & accessible at: https://www.covid-nma.com/dataviz/ and trial results are available at: https://covid- nma.com/living_data/index.php. A living systematic review of vaccine trials is also accessable at https://covid-nma.com/vaccines/ or https://covid-nma.com/ . Vaccines [1] Indonesia- Indonesia has approved the use of Sinovac Biotech vaccine for elderly. [2] Iran- A second locally manufacture vaccine, Razi COV-Pars, made by Razi Vaccine and Serum Research Institute will begin its human trials in Iran with about 130 volunteers for its first phase. Therapeutics No new updates were reported on 8 February 2021. 16 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 Vaccine Approval Status Table 6: Number of approving countries per vaccine Vaccine Number of countries approving FBRI EpiVacCorona 1 BioNTech/Pfizer BNT162b2 55 Moderna mRNA-1273 37 CanSino Ad5-nCoV 1 Gamaleya Sputnik V 16 Oxford/AstraZeneca AZD1222 43 Serum Institute of India Covishield 8 Bharat Biotech Covaxin 1 Sinopharm BBIBP-CorV 11 Sinopharm Inactivated 2 Sinovac CoronaVac 5 Source: https://covid19.trackvaccines.org/vaccines/ Adverse Reactions & Effects The following table documents adverse reactions reported from approved vaccines and therapeutics. New updates are bolded. Table 7: Compilation of reports & guidance on adverse reactions Vaccine Report/Guidance Reference [Canada; Report] One person in Manitoba reportedly had an adverse reaction after receiving the first dose on December 23. There were 490 [1] more individuals vaccinated. [United Kingdom; Report] Two British healthcare workers suffered [2] anaphylactic shock after receiving the vaccine. [United States; Report] A healthcare worker in New York City suffered anaphylaxis after receiving Pfizer BioNTech’s vaccine. The worker is [3] currently in a stable condition. 30,000 people have been vaccinated so Pfizer BioNTech far. [United States; Report] Two healthcare workers in northern Idaho and the Treasure Valley, experienced severe allergic reactions after receiving [4] the vaccine. As of the time of reporting, one has fully recovered while the other is expected to be discharged soon. [United States; Report] There have been two cases of severe allergic reaction in Alaska after receiving the COVID-19 vaccine. Symptoms of [5] the latest case include tongue swelling, hoarse voice and difficulty breathing, which kicked in about 10 mins after receving the vaccine. 17 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 [United States; Report] An individual at Decatur Morgan hospital, Alabama, experienced severe allergic reaction several minutes after [6] getting the vaccine. The patient is currently in a stable condition. [United States; Report] Two healthcare workers from Essentia Health, Minnesota had non-severe allergic reactions to the vaccine. About 2,500 [7] doses of the vaccines have been administered to frontline workers at Essentia Health. [United States; Report] According to Pfizer’s data submitted to the FDA, the most common side effects were swelling and redness at the vaccine injection site. Other noted common side effects in the trial included [8] fatigue, headache and muscle pain, which had a greater chance of occurring after the second dose than the first dose. [United States; Guidance] The Centers for Disease Control and Prevention (CDC) has issued new guidance on 21 December regarding allergies and coronavirus vaccines after reports of severe allergic [9] reactions to the jab. In the new guidance, the CDC recommends that those who have a severe reaction to the first shot of the vaccine should not receive the second jab. [United States; Guidance] Health experts have said that the side effects of COVID-19 vaccines by Pfizer BioNTech (and Moderna) are short-term and manageable. The American College of Allergy, Asthma & Immunology recently released a guideline on the risk of allergic [10] reactions to Pfizer BioNTech’s vaccine. The guideline is available at https://acaai.org/news/american-college-allergy-asthma-and- immunology-updates-guidance-risk-allergic-reactions-mrna. [Canada; Report] Of 11,930 doses of Pfizer BioNTech’s vaccine administered in British Columbia so far there have been 2 cases of [11] allergic reaction. [Israel; Report] On December 28, a 46-year-old man in Jerusalem suffered severe anaphylactic shock one hour after receiving a COVID-19 vaccination. He is the first in Israel to have such a reaction, and is reportedly allergic to penicillin. His condition has since stabilized. [12] Separately, a 75-year old man died of heart failure at home some hours after receiving Pfizer BioNTech’s vaccine. The man was reported to have heart disease and cancer, and had suffered a number of previous heart attacks. While investigations are still ongoing, preliminary findings indicated that the death did not appear to be connected to the shot. [Finland; Report] On January 2, the first adverse reaction against the [13] vaccine was reported. No further details were released. [Mexico; Report] A 32-year-old doctor in Mexico has been admitted to intensive care unit with seizures, breathing difficulties and possible encephalomyelitis. While the cause of the adverse reaction is still under investigation, preliminary diagnosis indicates encephalomyelitis. The patient condition has been stablized and is receiving treatment to [14] reduce inflammation. [15] [Update] The doctor was allergic to sulfa drugs and has a family history of allergies. After developing allergic reaction, medication was administered to recover from the symptoms. However, she had subsequently suffered from convulsion. Diagnosis at that time was 18 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 allergic reaction to the vaccine but the cause for convulsion and reduction of muscle strength is still being studied. [Bulgaria; Report] As of January 4, Bulgaria’s Medicines Agency had received four reports of adverse reactions. One case of dizziness after administration, two cases of local pain at the vaccinated site, and one [16] case of a slight temperature increase. These side effects had passed off in less than a day. [Portugal; Report] A portugese health worker had suffered a sudden death 2 days after being vaccinated on 30 Dec. She did not suffer from any adverse side-effect after vaccinated and did not has any health problem. An autopsy is expected to be conducted soon. [17] [18] [Update] In a 5 January 2020 press release, the Portuguese Ministry of Justice informed that preliminary data from the autopsy showed “no evidence of a causal relationship between the death and the vaccine that was received.” [Mexico; Report] By January 5, more than 44,000 people have received the first shot. As of January 4, about 110 people had reported allergic reaction to the vaccine but 80% were mild and only 5 people require hospitalization. Only one person was severely affected and remain in hospital. [Update] As of 16 January 2021, 753 adverse events (729 mild and 24 [19] serious) allegedly caused by vaccination and immunization were [20] reported since 24 December 2020. The 24 serious events were reported from Coahuila (7 reports), Mexico City (4 cases), Chihuahua, State of Mexico, Guanajuato, Oaxaca and Yucatan (2 reports each) and Baja California, Hidalgo and Jalisco (1 report each). Of the 24 serious events reports, 6 remain hospitalized while the remaining have been discharged. [United States; Publication] Centre of Disease Control and Prevention (CDC) has reviewed on the allergric reaction to the first dose of vaccine during 14 to 23 December. Among the 1,893,360 first doses administered, 4,393 (0.2%) adverse events were reported. 21 cases of anaphylaxis (11.1 cases per million doses) were detected and 17 of them had history of allergies or allergy reaction. Of the 21 cases, 4 of them were hospitalized including 3 in intensive care and 20 of them had discharged or recovered by 23 December. There were no death [21] reported. [22] [23] [Update] The total number of cases of anaphylaxis has been updated to 29 as on 6 January. [Update] CDC has roughly estimated that one in a hundred thousand people who received the Pfizer vaccine had severe allergic reactions. An average rate of 11.1 anaphylaxis cases per one million doses administered was estimated. [United States; Report] A Florida doctor had died several weeks after receiving the vaccine on 18 Dec. He had suffered from hemorrhagic [24] stroke due to a lack of platelets. It is unclear if his death was related to [25] the vaccine while his death is being investigated. It was reported that he 19 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 had dots on the skin indicating internal bleeding 3 days after the injection. Pfizer and BioNTech had not received any prior indication of possible connection to thrombocytopenia. [Update] As of 12 Jan, no evidence was obtained to suggest a connection between the vaccine and the death. [Canada; Report] Nine reports of adverse medical reactions which include a total of 65 symptoms, eight of which were considered severe, have been reported as of Jan. 1 but none were considered to be unexpected side effects. [Update] Fifteen new reports of adverse medical reactions, five of which were considered severe, have been reported as between January 1 and January 8. As of January 8, 24 reports of adverse effects were reported, [26] consisting of 10 serious and 14-nonserious reports. All reports were [27] considered to be expected side effects. [28] [Update] Sixty-six new reports of adverse medical reactions, 17 of which were considered severe, have been reported as between January 9 and January 15. As of January 15, 90 reports of adverse effects were reported, consisting of 27 serious and 63-nonserious reports. Most frequently reported adverse events were vaccination site reactions, paraesthesia, pruritis, urticaria, headache, hypoaesthesia, nausea and anaphylaxis. [France; Report] Six reports of serious adverse effects with a favourable outcome were reported in France during the 3rd week of vaccination: 4 [29] cases of allergic reactions and 2 cases of tachycardia. Around 30 cases of non-serious adverse effects have been reported since 12 Jan 2021 [Norway; Report] As of 14 Jan 2021, 29 reports of side effects were reported in Norway. The 29 reports consisted of 13 deaths, 9 serious side effects and 7 less serious side effects. The deaths were all amongst frail and elderly patients in nursing homes, aged at least 80 years. [30] Serious side effects reported included allergic reactions, strong malaise and severe fever. Less serious side effects include severe pain at injection site. [United States; Report] A healthcare worker in Alaksa experienced an allergic reaction to the Moderna COVID-19 vaccine, 10 minutes within [31] receiving it on January 12. There was no information on allergy history of the healthcare worker. [Israel, Report] At least 13 cases of mild facial paralysis have been [32] reported upon receiving the vaccine. [United Kingdom, Report] A severe adverse medical reaction was reported from a medical councillor aged 42 years within minutes after receiving his vaccine on 8 January 2021. The councilor experienced [33] breathing difficulties, fever and muscle aches, and was hospitalized for 1 day before his condition stabilized and eventually recovered. [Ireland, Report] As of 11 January 2021, 81 adverse events from [34] vaccination were reported, all involving expected mild side effects. [Singapore, Report] As of 27 January 2021, a total of 432 AEFIs were [35] reported amongst the 113,000 people who received the vaccine. All [36] reports were mild and reported expected side effects arising from 20 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 vaccination, except for 3 cases of anaphylaxis (SAE) reported. The cases were in their 20s and 30s, had a history of allergies, but no history of anaphylaxis which would have precluded them from receiving the vaccine. All 3 cases have recovered and were discharged from the hospital after a day’s observation or treatment. [Update] As of February 1, 2021 all four cases of anaphylaxis following vaccination have recovered, with none requiring intensive care unit support. [Belgium, Report] As of January 26, 2021 a total of 262 AEFIs were reported out of 243,412 vaccines administered, of which 37 were [37] serious AEFIs. Of the serious AEFIs reported, 14 were deaths amongst those aged over 70 years (9 deaths) or 90 years (5 years). [Croatia, Report] As of February 1, 2021 a total of 430 AEFIs were reported, of which 26 were allergic reactions and the rest were mild side [38] effects. The allergic reactions included 2 serious reactions, and 24 milder reactions. [United Kingdom; Report] A study conducted by Zoe, a British health science company had found that 37% of about 40,000 vaccinees in UK who were mostly healthcare workers had reported local side effects (e.g. swelling or pain near injection site) after first dose and 45% after [39] second dose. Systemic side effects (e.g. fatigue) were rare with 14% after first dose and 22% after second dose. The side effect reported were lower as compared to FDA trials. [Romania; Report] A doctor from Valcea county had experienced temporary facial paralysis after receiving the second dose and has since fully recovered. This is the first rare and major side effect reported in [40] Romania. Since 27 Dec, there has been more than 2,100 common and minor side effects reported with a total of 629,279 people vaccinated by 4 Feb. [United Kingdom; Report] The Medicines and Healthcare products Regulatory Agency (MHRA) had reported on the side effects of 7 million vaccine doses (5.4 million Pfizer/BioNTech & 1.5 million of the AstraZeneca) administered by 24 Jan. Yellow card system was used for vaccinated people to report side effect. There was an average of 3 yellow cards per 1,000 doses administered. There were 16,756 yellow [41] card for the Pfizer-BioNTech vaccine; 6,014 for the Oxford University- AstraZeneca vaccine and 50 for unspecified brand of the vaccine. Most reports were related to injection site or otherwise generalized symptoms (e.g. flu-like illness). These symptoms had occured shortly after vaccination and were not associated with more serious or lasting illness. [United States; Report] The FDA advisory committee has noted a special side effect of the vaccine from the clinical trials involving several patients with cosmetic facial fillers. The patients who experienced side [42] effect all had swelling and inflammation in the area that was given the Moderna filler. All reactions were resolved following treatment with steroids and antihistamines. [United States; Report] A Boston doctor experienced severe allergic reactions after receiving the Moderna COVID-19 vaccine on December [43] 24. The doctor has a history of shellfish allergy. 21 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 [Canada; Report] On December 17, the US FDA reported two cases of adverse reactions in individuals who had received the Moderna vaccine. Both patients previously had dermal fillers and experienced some [44] swelling following the vaccination. The cases were likely to have occurred in Toronto, Canada. [United States; Report] A frontline worker in Robstown had experienced immediate numbness on the face after receiving the vaccine a week ago [45] but continues to have soreness and redness to her arms. [United States; Publication] Phase 3 clinical trial involving 30,420 volunteers had observed higher frequency of moderate, transient reactogenicity after vaccination in the vaccine group. Serious adverse events were rare and the incidence was similar between the placebo and vaccine groups. Hence there were no safety concern, apart from the [46] transient local and systemic reactions. [47] [Update] The vaccine showed a 94.1% efficacy rate in its phase 3 trial, and serious adverse events occurred in just 0.6% of patients. A total of 2 deaths were reported in the vaccine group, one was due to cardiopulmonary arrest and the other was a suicide. [United States; Report] On 31 December, the Oregon Health Authority reported a case of anaphylaxis after a healthcare worker had taken the [48] vaccine this week and is recovering in the hospital. [Guidance] A new guidance from the American Society for Dermatologic Surgery (ASDS) has been released regarding side effects from the SARS- CoV-2 mRNA vaccine on dermal fillers. FDA data reports show three [49] participants out of 15,184 who received at least one dose of Moderna’s mRNA-1273 vaccine have developed lip for facial swelling in areas of dermal filler placement. [United States; Report] A Missouri healthcare worker experienced severe allergic reaction after receiving the Moderna COVID-19 vaccine [50] on December 29. The healthcare worker has a history of severe allergy reaction to MRI contrast dye. [United States, Report] Six reports of allergy reactions requiring medical attention 24 hours from vaccination, were reported amongst healthcare workers on 14 January 2021. The healthcare workers were vaccinated with lot 41L20A from the same vaccination site in San Diego. The site is [51] temporarily closed for now and using other vaccines. California health officials recommend suspending the use of lot 41L20A, until investigation are complete. [United States, Report] A fatality was reported in a resident from a retirement home, after receiving the vaccine. Investigation on whether [52] the fatality was linked to receiving the vaccine is underway. [United States, Report] As of January 29, 2021 a total of 287 AEFIs were reported amongst 250,000 vaccines administered in Texas, of which 11 were serious AEFIs. The 11 AEFI reports included the death of an 84 years-old woman, permanent disability in another patient, and the [53] remaining spent at most 4 days hospitalized. [54] [Update] As of 5 Feb, 2021, the The Centers for Disease Control had reported that 619,452 second doses have been administered in Texas 22 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 with 15 significant reports of side effect. Only 4 of them required hospital stay that had lasted less than 5 days. [Croatia, Report] As of February 1, 2021 a total of 13 AEFIs were [55] reported, all of which were mild side effects. [Argentina; Report] Of the total 32,013 patients who had received the Sputnik V vaccine, 1% (317 patients) had reported mild adverse reaction (fever [56] and headache). [India, Report] Ninety-three reports of adverse events following immunization with Astrazeneca & Oxford Uni. ( and Bharat Biotech) vaccines were reported from Delhi (51 mild and 1 serious report), Haryana (13 mild reports), Maharashtra (14 mild reports) and Kolkata (13 mild and 1 serious report). No fatalities have been reported. [Update] Between 16 January and 17 January, 447 reports of adverse events following immunization have been reported across India. Only 3 of the reports involved serious adverse events requiring hospitalization, of which only 1 remains hospitalized. [Update] 82 AEFIs were reported across India on 20 January 2021. All AEFIs reported were mild cases. [Update] On the 22 Jan, Day 4 of the coronavirus vaccination drive in Delhi, 5,942 people were reportedly administered the shots and adverse events following immunisation (AEFI) was reported in 24 persons. [57] [58] [Update] On 24 Jan, the fifth day of India’s Covid-19 vaccination drive, [59] the city of Gurugram reported 3 cases of AEFI amongst 3,055 shots [60] Astrazeneca & administed. [61] Oxford Uni. [62] [Update] The Union Ministry of Health and Family Welfare in India [63] announced 23 January that over 10 lakh people had already been [64] immunised in the first six days (up to 21 January), but the total number [65] of AEFIs reported by the ministry in its daily press releases so far adds up [66] to 1,239 out of 15,37,190 inoculations, or 0.08 per cent. Just 11 people have had to be hospitalised (0.0007 per cent), while seven deaths have been reported — six of which are “not causally linked” to the vaccine, while in the seventh case, the post mortem report is awaited. [Update] A total of 19,50,183 beneficiaries were inoculated in 35,785 sessions till 7.10 pm on Monday 25 Jan, including 3,34,679 in 7,171 sessions during the day, the ministry said. A total of 348 adverse events following immunisation (AEFIs) were reported till 7.10 pm on 25 Jan, the 10th day of the vaccination drive. [Update] A total of 213 ARFIs were reported up till 7 pm on January 29, 2021 across India, of the 33,68,734 vaccines administered [Update] The Minstry of Health and Family Welfare had reported more than 40 lakh healthcare and frontline workers have been vaccinated. A total of 8,563 AEFIs (0.18%) and 34 hospitalized cases (0.0007%) have 23 | P a g e Centre for infectious disease epidemiology and research
For citation: Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 375. 8 February 2021 been reported. There were 19 deaths of vaccinated people but there has been no evidence on the link between vaccination and the death. [India, Report] A female volunteer from a village in Andhra Pradesh had died 2 days after administered with the vaccine on 5 Feb. She was Unspecified normal and there was no symptoms of fever or adverse effect after the [67] vaccination. Post-mortem will be conducted to identify the cause of death. Therapeutic/Drug Report/Guidance Reference NIL NIL NIL x. Scientific Publications with Epidemiology and Clinical Focus Clinical Stratification of Pregnant COVID-19 Patients based on Severity: A Single Academic Center Experience [1] Objective: The aim of this study was to describe baseline characteristics of a cohort of pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and determine if these correlate with disease severity and perinatal outcomes. Study design: This was a retrospective cohort trial conducted at the University of Texas Medical Branch Galveston, Texas. All pregnant women presented to our medical center, who were screened and tested positive for SARS-CoV-2 virus, were included. We stratified our study population in three groups: asymptomatic, symptomatic not requiring oxygen therapy, and patients requiring oxygen support to maintain oxygen saturation >94%. Relevant population characteristics, laboratory data, and maternal and neonatal outcomes were abstracted. A p-value
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