Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables June 10, 2021 - Ontario COVID-19 Science ...

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Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables June 10, 2021 - Ontario COVID-19 Science ...
Update on COVID-19 Projections
  Science Advisory and Modelling Consensus Tables
                    June 10, 2021
Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables June 10, 2021 - Ontario COVID-19 Science ...
Key Findings

• Cases, percent positivity, and hospitalizations have all dropped sharply
  thanks to the commitment of Ontarians.
• Cases should continue to decline for the next 10 days. As vaccination
  continues, it will be important to monitor carefully for new variants and
  continue assessing for signs of breakthrough and serious infection.
• The Delta variant is more transmissible and may be more dangerous. It will
  likely be the dominant form of the virus this summer. It is critical to control
  the spread of this variant.
• To avoid a fourth wave, we need to continue to ensure first and second
  doses in high-risk communities, continue tailoring vaccine clinics to
  community needs, and ensure strong testing and case and contact tracing.
                                                                                    2
Weekly new cases per 100,000 residents

                                                                                         100
                                                                                               150
                                                                                                     200
                                                                                                                 300

                                                                                                           250

                                                                                    50

                                                                                0

                                                Data source: CCM
                                                                       Porcupine
                                                                     Thunder Bay

                                                                             Peel
                                                                        Hamilton
                                                                           Brant
                                                                         Durham

Data note: Data for the most recent day have
been censored to account for reporting delays
                                                                        Waterloo
                                                                         Toronto
                                                                         Niagara
                                                                            York
Wellington-Dufferin-Guelph
                                                Middlesex-London
                                                                   Windsor-Essex
                                                                          Ottawa
                                                                   Haliburton KPR
                                                                                                                   May 24

                                                                          Halton
                                                         Simcoe Muskoka
                                                                        Lambton
                                                                     Huron Perth
                                                Haldimand-Norfolk
                                                                                                                            Average weekly cases on:

                                                                    Peterborough
                                                                                                                   June 6

                                                                    Southwestern
                                                                         Renfrew
                                                                   Chatham-Kent
                                                                          Eastern
                                                                      Grey Bruce
                                                                         Sudbury
                                 North Bay Parry Sound
                                                                            KFLA
                                                                   Hastings & PEC
                                                                    Northwestern
                                                                         Algoma
                                                                                                                                                       Cases have decreased sharply in almost all Public Health Units

                                                                     Timiskaming
                                   Leeds Grenville Lanark
        3
% positivity has declined sharply since the last briefing
                                                                                                                                             Dec 26                             Jan 18                     Apr 3                         Apr 17
                                                                                                                           Province-wide lockdown                               First dose         Province-wide                         Enhanced public health
% positivity of daily testing episodes

                                                                                                                            14-days for N. Ontario                              vaccination      emergency brake                         measures and enforcement
                                                                                                                             28-days for S. Ontario                             In LTC in
                                                        18                                                                                                                      prioritized PHUs

                                                        16

                                                        14
                                         (7-day avg.)

                                                        12

                                                        10
                                                                                                                                                                                                                                                                       Porcupine, 9.5%
                                                        8
                                                                                                                                                                                                                                                                       Peel, 6.3%
                                                        6                                                                                                                                                                                                              Hamilton, 6.1%
                                                                                                                                                                                                                                                                       Waterloo, 5.5%
                                                        4                                                                                                                                                                                                              Toronto, 4.0%
                                                                                                                                                                                                                                                                       Ontario, 3.2%
                                                        2

                                                        0

                                                                                                                                                                                                                                                           May 22
                                                                     Aug 15

                                                                              Aug 29

                                                                                                                                     Nov 21

                                                                                                                                                                                                              Mar 13

                                                                                                                                                                                                                       Mar 27

                                                                                                                                                                                                                                Apr 10

                                                                                                                                                                                                                                          Apr 24
                                                                                                         Oct 10

                                                                                                                  Oct 24

                                                                                                                                                                                                     Feb 27
                                                                                                                                                      Dec 19

                                                                                                                                                                                            Feb 13
                                                                                       Sep 12

                                                                                                Sep 26

                                                                                                                                                                       Jan 16

                                                                                                                                                                                   Jan 30

                                                                                                                                                                                                                                                   May 8
                                                             Aug 1

                                                                                                                             Nov 7

                                                                                                                                              Dec 5

                                                                                                                                                                                                                                                                    Jun 5
                                                                                                                                                               Jan 2

                                                                          Specimen Date                                                                                                                                                                                                  4
     Data source:Ontario Laboratory Information System (OLIS), data up to June 4
Testing has declined. Continued strong monitoring will be
                                               critical for control of the pandemic.
                                              700
Testing episodes per 100,000

                                              600

                                              500
                               (7-day avg.)

                                                                                                                                                                                                                                                        Porcupine, 442
                                              400

                                              300

                                              200
                                                                                                                                                                                                                                                        Ontario, 172

                                              100                                                                                                                                                                                                       Timiskaming, 107

                                               0

                                                                                                                                                                                                                                            May 22
                                                            Aug 15

                                                                     Aug 29

                                                                                                                          Nov 21

                                                                                                                                                                                                Mar 13

                                                                                                                                                                                                         Mar 27

                                                                                                                                                                                                                  Apr 10

                                                                                                                                                                                                                           Apr 24
                                                                                                Oct 10

                                                                                                         Oct 24

                                                                                                                                                                              Feb 13

                                                                                                                                                                                       Feb 27
                                                                                                                                           Dec 19
                                                                              Sep 12

                                                                                       Sep 26

                                                                                                                                                            Jan 16

                                                                                                                                                                     Jan 30

                                                                                                                                                                                                                                    May 8
                                                    Aug 1

                                                                                                                  Nov 7

                                                                                                                                   Dec 5

                                                                                                                                                                                                                                                     Jun 5
                                                                                                                                                    Jan 2

                                                                         Specimen Date
                                                                                                                                                                                                                                                                           5
 Data source:Ontario Laboratory Information System (OLIS), data up to June 4
COVID-19 hospitalizations and ICU occupancy have dropped
 2500

                 Patients in Inpatient Beds with COVID19

 2000            Patients in ICU with COVID-Related Critical
                 Illness

 1500

 1000

  500

    0

Data Sources: MOH COVID Inpatient Census and Critical Care Information System
                                                                                6
Continuing control of the pandemic will be key to reducing
                                the access-to-care deficit
                      150%

                      100%
                                                                           Most urgent surgeries
 Change vs Previous Year† (%)

                                                                                                         HOLIDAYS
                                50%

                                0%
                                                                           Semi urgent surgeries

                                                                                 Least urgent…
                           -50%

              -100%
                                      Apr 2020   May   Jun   Jul     Aug   Sep     Oct    Nov.     Dec     Jan. 2021   Feb   Mar   Apr   May

Data Source: Wait Times Information System                                                                                                     7
                                                                   2020                                     2021
Ontarians’ commitment to public health measures means we
are doing much better since the last briefing
                                         5,000
Figure shows
                                         4,500
predictions based on 4
                                         4,000
models.
                                         3,500
• Partial reopening June                 3,000

                           Daily Cases
  14                                     2,500                                                                    Range from
• Vaccinating 140k-                      2,000
                                                                                                                  last briefing

  180k/day                               1,500
• Delta VOC considered                   1,000
• Different levels of                     500
  disease spread after                      -
  Step 1 opening

                                                 03/05

                                                 04/23
                                                 01/01
                                                 01/08
                                                 01/15
                                                 01/22
                                                 01/29
                                                 02/05
                                                 02/12
                                                 02/19
                                                 02/26

                                                 03/12
                                                 03/19
                                                 03/26
                                                 04/02
                                                 04/09
                                                 04/16

                                                 04/30
                                                 05/07
                                                 05/14
                                                 05/21
                                                 05/28
                                                 06/04
                                                 06/11
                                                 06/18
                                                 06/25
                                                 07/02
                                                 07/09
                                                 07/16
                                                 07/23
                                                 07/30
                                                 08/06
                                                 08/13
                                                 ON - Daily         ON - 7-Day Average         High, 142k/day                  High, 180k/day
                                                 Medium, 142k/day   Medium, 180k/day           Low, 142k/day                   Low, 180k/day

                                                                                   Predictions informed by modeling from Fields Institute, McMasterU, PHO, YorkU
                                                                                                                       Data (Observed Cases): covid-19.ontario.ca   8
If we continue to control COVID-19, we can drop below 200 COVID-
19 patients in ICUs by mid-July and begin to resume normal hospital
operations
                                                                                                        ICU Occupancy
1,000
                                                                                                                                                                                        Range from
 900
                                                                                                                                                                                        last briefing
 800
 700
 600
 500
 400
 300
 200
 100
   -
                                                                                                03/18

                                                                                                                                                        05/06
        12/31

                01/07

                        01/14

                                01/21

                                        01/28

                                                02/04

                                                        02/11

                                                                02/18

                                                                        02/25

                                                                                03/04

                                                                                        03/11

                                                                                                        03/25

                                                                                                                04/01

                                                                                                                        04/08

                                                                                                                                04/15

                                                                                                                                        04/22

                                                                                                                                                04/29

                                                                                                                                                                05/13

                                                                                                                                                                        05/20

                                                                                                                                                                                05/27

                                                                                                                                                                                        06/03

                                                                                                                                                                                                06/10

                                                                                                                                                                                                        06/17

                                                                                                                                                                                                                06/24

                                                                                                                                                                                                                        07/01

                                                                                                                                                                                                                                07/08

                                                                                                                                                                                                                                        07/15
                            ON - Daily                             ON - 7-Day Average                      Predicted                               High, 142k/day                         High, 180k/day
                            Medium, 142k/day                       Medium, 180k/day                        Low, 142k/day                           Low, 180k/day

                                                                                                                                                                                                     Predictions: COVID-19 ModCollab.           9
                                                                                                                                                                                                 Data (Observed ICU Occupancy): CCSO
The 2nd vaccine dose is more than 2x as effective against the
Delta variant – it is key to get 2nd doses in arms
Delta variant (B.1.617.2)
• About 50% more transmissible
   than Alpha (B.1.1.7)
• Will likely be the dominant
   variant in the early summer
• Risk of hospitalization may be
   increased
• 1st dose of vaccine less effective
   against symptomatic disease
   but it may protect against
   severe disease

   Source: SARS-CoV-2 variants of concern and variants under   Source: Estimated from Bernal et al, BMJ 2021; Bernal et al, medRxiv 2021   10
   investigation in England Technical briefing 14
Continuing a strategy based on age and community risk will help
control the spread and impact of the Delta variant

Protect all regions with 1st doses, avoid         Protect regions at high-risk of Delta with
‘pockets’ with low coverage                       increased 1st and 2nd dose coverage
• Minimize risk of introduction and               • Control surges in Delta-high-risk areas
  propagation of Delta-variant
                                                  • Minimize risk of spillover into other areas
• Continue core public health functions of
                                                  • Continue core public health functions of
  case and contact tracing, testing
                                                    case and contact tracing, testing

Benefits of continuing a focus on high-risk communities
• Compared to a pure age-based allocation, continuing a high-risk community strategy
    reduces the overall case count by 39% (both with 2nd dose eligibility at 6 weeks)
• Much of the reduction in cases are in lower-risk communities; benefitting all communities
Technical Note: Modelling based on 2nd dose coverage of 45% in high-risk regions and 25% in
all other regions by the end of June, 70% 1st dose coverage for all regions
                                                                                                  11
Vaccination coverage continues to increase
Provincial progress
   (Age 18 or older)                                                                        72.8%                                                                                                27.2%

     2,500,000

     2,000,000
                                                                                                                                                                                            Population remaining

     1,500,000
                                                                                                                                                                                            Has made an appointment
                                                                                                                                                                                            for first dose*
     1,000,000

                                                                                                                                                                                            Number of individuals
       500,000                                                                                                                                                                              with at least one dose

              -
                         80+              70 to 79            60 to 69           50 to 59            40 to 49            30 to 39            18 to 29            12 to 17

   * Note that this is just Pending Appointments. Anyone who has made an appointment and received a vaccine will be counted under “Individuals with at least one dose”. Data for Appointments reflect 21 PHUs that are captured
   through the provincial booking system. Appointments made through other systems (e.g., local PHU booking systems, pharmacies, primary care) are not included.
   ^ Age is based on year of birth.

   Data Sources
   MOF 2020 Population Projections
   COVAX analytical file, extracted 8:00pm June 6 2021, CPAD, MOH
   COVAX Skedulo, extracted 6:00pm June 6 2021
                                                                                                                                                                                                                                  12
The high-risk community strategy has helped
Figure excludes long-term care vaccination – at least 1 dose as of June 7, 2021

                                                                              Source: ICES   13
Key Findings

• Cases, percent positivity, and hospitalizations have all dropped sharply
  thanks to the commitment of Ontarians.
• Cases should continue to decline for the next 10 days. As vaccination
  continues, it will be important to monitor carefully for new variants and
  continue assessing for signs of breakthrough and serious infection.
• The Delta variant is more transmissible and may be more dangerous. It will
  likely be the dominant form of the virus this summer. It is critical to control
  the spread of this variant.
• To avoid a fourth wave, we need to continue to ensure first and second
  doses in high-risk communities, continue tailoring vaccine clinics to
  community needs, and ensure strong testing and case and contact tracing.
                                                                                    14
Contributors
• COVID Vaccination Strategy Modeling Group: Sharmistha Mishra, Jesse Knight, Huiting Ma, Kevin Brown,
  Amir Ghasemi, Kamil Malikov, Michael Paterson, Hannah Chung, Andrew Calzavera, Kinwah Fung, Kristy Yiu,
  Sarah Buchan, Sarah Wilson, Leigh Hobbs, Linwei Wang, Stefan Baral, Rafal Kustra, Gary Moloney, Nathan
  Stall, Jeff Kwong, Peter Jüni & Beate Sander
• COVID-19 Modeling Collaborative: Kali Barrett, Stephen Mac, David Naimark, Aysegul Erman, Yasin Khan,
  Raphael Ximenes, Sharmistha Mishra, Beate Sander
• Fields Institute: Taha Jaffar, Kumar Murty
• ICES: Jeff Kwong, Hannah Chung, Kinwah Fung, Michael Paterson, Susan Bronskill, Laura Rosella, Astrid
  Guttmann, Charles Victor, Michael Schull, and Marian Vermeulen
• McMasterU: Irena Papst, Michael Li, Ben Bolker, Jonathan Dushoff, David Earn
• YorkU: Jianhong Wu, Yanyu Xiao, Zack McCarthy
• MOHLTC: Michael Hillmer, Kamil Malikov, Qing Huang, Jagadish Rangrej, Nam Bains, Jennifer Bridge
• OH: Erik Hellsten, Stephen Petersen, Anna Lambrinos, Chris Lau, Access to Care Team
• PHO: Kevin Brown
• Science Advisory Table: Peter Juni, Antonina Maltsev, Bruno da Costa

                                                                                                            15
Content provided by Modelling Consensus and Scientific
Advisory Table members and secretariat
Beate Sander,* Peter Juni, Brian Schwartz,* Kumar Murty,* Upton Allen, Vanessa Allen, Kali Barrett,
Nicholas Bodmer, Isaac Bogoch, Kevin Brown, Sarah Buchan, Yoojin Choi, Troy Day, Laura Desveaux,
David Earn, Gerald Evans, David Fisman, Jennifer Gibson, Anna Greenberg, Anne Hayes,* Michael
Hillmer, Jessica Hopkins, Jeff Kwong, Fiona Kouyoumdjian, Audrey Laporte, John Lavis, Gerald
Lebovic, Brian Lewis, Linda Mah, Kamil Malikov, Antonina Maltsev, Doug Manuel, Roisin McElroy,
Allison McGeer, David McKeown, John McLaughlin, Sharmistha Mishra, Justin Morgenstern, Andrew
Morris, Samira Mubareka, Laveena Munshi, Christopher Mushquash, Ayodele Odutayo, Shahla
Oskooei, Menaka Pai, Samir Patel, Anna Perkhun, Bill Praamsma, Justin Presseau, Fahad Razak, Rob
Reid,* Paula Rochon, Laura Rosella, Michael Schull, Arjumand Siddiqi, Chris Simpson, Arthur Slutsky,
Janet Smylie, Nathan Stall, Robert Steiner, Ashleigh Tuite, Jennifer Walker, Tania Watts, Ashini
Weerasinghe, Scott Weese, Xiaolin Wei, Jianhong Wu, Diana Yan, Emre Yurga

* Chairs of Scientific Advisory, Evidence Synthesis, and Modelling Consensus Tables
For table membership and profiles, please visit the About and Partners pages on the Science
Advisory Table website.

                                                                                                       16
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