The 2020/1 Blended Learning Journey on Metastatic Renal Cell Carcinoma (mRCC) LIVE WEBINAR for APAC - Saturday, 24 April 2021
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The 2020/1 Blended Learning Journey on Metastatic Renal Cell Carcinoma (mRCC) LIVE WEBINAR for APAC Saturday, 24 April 2021 from 11:00 to 12:00 CEST
OVERVIEW Renal Cell Carcinoma (RCC) is a common tumor of the elderly, which has consistently increased in incidence over the past decade. While operative techniques have advanced in recent years and now offer renal preservation and minimal operative trauma where possible, adjuvant measures are not established. Medical treatment remains mostly confined to those with relapsed or metastatic disease, when local therapies are not suitable. The first wave of medical treatments for RCC consisted of cytokines, which had some impact on patient prognosis (overall survival increased to a median of 13 months), but clearly lacked efficacy. Unraveling the molecular carcinogenesis of clear cell RCC spurred the development of targeted therapies, tyrosine kinase inhibitors (TKI), which inhibit the tumor vasculature and have noticeably improved the efficacy of RCC medical treatment. More recently, check point inhibitors (CPI) have entered the therapeutic arena - the latest milestone of clinical development. These tools allow further optimization of treatment by permitting combinations of different therapies. Today, first-line therapies are composed of CPI- based combinations, which have shifted median overall survival expectation to >40 months. This live webinar brings together a panel of international experts, who will discuss the rapid development of medical treatments with a particular focus on contemporary medical treatment in advanced or metastatic RCC. LEARNING OBJECTIVES By attending this live educational webinar learners will be able to: • Diagnose RCC and categorize the disease into stages • Use the stages of disease to help inform therapy decisions • Know the latest guideline recommendations for patients with RCC • Understand the science/trials behind the latest guideline updates • Be more confident about prescribing choices for patients at all stages of RCC TARGET AUDIENCE This webinar is designed for Oncologists, Urologists and specialists from the APAC Region, involved in the diagnosis and management of patients with metastatic renal cell carcinoma (mRCC). LANGUAGE The official language of this live educational webinar is English. Simultaneous translation into Japanese will be provided. CME ACCREDITATION The 2020/1 Blended Learning Journey on Metastatic Renal Cell Carcinoma (mRCC) - LIVE WEBINAR for APAC, 24/04/2021 - 24/04/2021 has been submitted for CME accreditation to the European Accreditation Council for Continuing Medical Education (EACCME®). 2
CME PROVIDER Scientific Seminars International Foundation CME Manager: Flaminia Masprone T +39 380 1504116 - F +39 06 4827169 info@scientificseminars.com PRE-REGISTRATION AND SURVEY To access the live webinar, please register by clicking on the below link: https://www.elearning.scientificseminars.com/the-2020-21-blended- learning-journey-on-metastatic-renal-cell-carcinoma-mrcc/live-webinar- for-apac/ and complete a very short survey covering your current knowledge of the subject matter prior to attending the webinar. 3
FACULTY Viktor Grünwald Jens Bedke Professor for interdisciplinary Department of Urology genitourinary oncology Eberhard Karls University Tübingen University Hospital Essen (AöR) Tübingen, Germany West-German Cancer Center Essen Clinic for Medical Oncology and Clinic for Urology Essen, Germany Eto Masatoshi Professor and Chairman Department of Urology Graduate School of Medical Sciences Kyushu University Fukuoka, Japan 4
SATURDAY, 24 APRIL 2021 from 11:00 to 12:00 CEST 11:00 Welcome and introduction V. Grünwald (Germany) 11:05 L1 Background and drug development in mRCC V. Grünwald (Germany) 11:15 L2 Current clinical data Eto Masatoshi (Japan) Abstract: The rapidly evolving treatment landscape of mRCC has led to the latest development of check point inhibitor (CPI)-based drug combinations in first line treatment. Although these combinations offer broad clinical activity and their use is associated with a median overall survival >40 months, the next generation of CPI-based combinations appeared. These later combinations combine CPIs with 3rd generation tyrosine kinase inhibitors (TKI) to broaden the clinical activity. We will discuss the latest data and their implication for the treatment landscape in mRCC. In details: • Javelin-101 renal • KN-426 • Checkmate 214 • Cheeckmate 9ER • CLEAR 11:30 L3 Clinical case - Individualizing therapy for a treatment naïve patient just diagnosed with mRCC: treatment options, and their progress on therapy J. Bedke (Germany) Abstract: We will present a case scenario of a patient with mRCC, who is rendered treatment-naïve. The interpretation of clinical data will be discussed, waying pros and cons of different treatment options in order to individualize therapeutic choices. 11:45 P Panel discussion 11:55 Summary and closing remarks V. Grünwald (Germany) 12.00 End of the live webinar LEGEND 5 L: Lecture; P: Panel discussion
All Scientific Seminars International Foundation programs are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. There may be presentations discussing investigational uses of various products. These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of Scientific Seminars International Foundation. This independent educational program is made possible thanks to an educational grant received from Merck Healthcare KGaA Darmstadt, Germany. 6
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