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                   Front Matter: Volume 6447

                                  , "Front Matter: Volume 6447," Proc. SPIE 6447, Nanoscale Imaging,
                                  Spectroscopy, Sensing, and Actuation for Biomedical Applications IV, 644701
                                  (20 February 2007); doi: 10.1117/12.728824

                                  Event: SPIE BiOS, 2007, San Jose, California, United States

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PROGRESS IN BIOMEDICAL OPTICS AND IMAGING
                                                                                                                                      Vol. 8, No. 24

                   Nanoscale Imaging, Spectroscopy,
                   Sensing, and Actuation for
                   Biomedical Applications IV

                   Alexander N. Cartwright
                   Dan V. Nicolau
                   Chairs/Editors

                   23–24 January 2007
                   San Jose, California, USA

                   Sponsored and Published by
                   SPIE—The International Society for Optical Engineering

                                                                                                                    Volume 6447
                                                                                                                    The International Society
                                                                                                                    for Optical Engineering

                                 Proceedings of SPIE—The International Society for Optical Engineering, 9780819465603, v. 6447

                                       SPIE is an international technical society dedicated to advancing engineering and scientific
                                         applications of optical, photonic, imaging, electronic, and optoelectronic technologies.

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The papers included in this volume were part of the technical conference cited on the cover and title
                                    page. Papers were selected and subject to review by the editors and conference program
                                    committee. Some conference presentations may not be available for publication. The papers
                                    published in these proceedings reflect the work and thoughts of the authors and are published herein
                                    as submitted. The publisher is not responsible for the validity of the information or for any outcomes
                                    resulting from reliance thereon.

                                    Please use the following format to cite material from this book:
                                       Author(s), "Title of Paper," in Nanoscale Imaging, Spectroscopy, Sensing, and Actuation for
                                    Biomedical Applications IV, edited by Alexander N. Cartwright, Dan V. Nicolau, Proceedings of SPIE
                                    Vol. 6447 (SPIE, Bellingham, WA, 2007) Article CID Number.

                                    ISSN 1605-7422
                                    ISBN 9780819465603

                                    Published by
                                    SPIE—The International Society for Optical Engineering
                                    P.O. Box 10, Bellingham, Washington 98227-0010 USA
                                    Telephone 1 360/676-3290 (Pacific Time)· Fax 1 360/647-1445
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                                    Copyright © 2007, The Society of Photo-Optical Instrumentation Engineers

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Contents

                           vii      Conference Committee

                 SESSION 1          MICRO- AND NANOSENSORS I

                     644703         Methods for monitoring and imaging nanoparticles in cells [6447-02]
                                    D. O. Lapotko, E. Y. Lukianova, S. A. Chizhik, Lykov Heat and Mass Transfer Institute (Belarus)

                     644706         Photon number-resolved detectors: prospects and applications (Invited Paper) [6447-05]
                                    A. Verevkin, Univ. at Buffalo (USA)

                     644707         From optical tweezers to optical forced oscillation: principles and potential biomedical
                                    applications [6447-06]
                                    M.-T. Wei, S.-L. Liu, T.-Y. Tseng, A. Karmenyan, A. Chiou, National Yang-Ming Univ. (Taiwan)

                     644709         A full-field heterodyne surface plasmon resonance dynamic bio-imaging system [6447-08]
                                    C.-H. Lin, Y.-D. Su, C.-H. Huang, K.-C. Cho, S.-J. Chen, National Cheng Kung Univ. (Taiwan)

                 SESSION 2          MICRO- AND NANOSENSORS II

                     64470B         The in-line-quadrature bioCD [6447-10]
                                    M. Zhao, X. Wang, D. Nolte, Purdue Univ. (USA)

                    64470C          Genomic signal analysis of Mycobacterium tuberculosis [6447-27]
                                    P. D. Cristea, Politehnica Univ. of Bucharest (Romania); D. Banica, Marius Nasta Institute of
                                    Physiology (Romania); R. Tuduce, Politehnica Univ. of Bucharest (Romania)

                    64470D          Imaging of cooperative motion on a simulated energy landscape [6447-12]
                                    V. V. Yakovlev, Univ. of Wisconsin, Milwaukee (USA); S. Nishikawa, JST, ICORP (Japan);
                                    T. Yanagida, Osaka Univ. (Japan)

             Pagination: Proceedings of SPIE follow an e-First publication model, with papers published first online and then in print and on
             CD-ROM. Papers are published as they are submitted and meet publication criteria. A unique, consistent, permanent citation
             identifier (CID) number is assigned to each article at the time of the first publication. Utilization of CIDs allows articles to be fully
             citable as soon they are published online, and connects the same identifier to all online, print, and electronic versions of the
             publication.

             SPIE uses a six-digit CID article numbering system in which:
             • The first four digits correspond to the SPIE volume number.
             • The last two digits indicate publication order within the volume using a Base 36 numbering system employing both numerals
             and letters. These two-number sets start with 00, 01, 02, 03, 04, 05, 06, 07, 08, 09, 0A, 0B … 0Z, followed by 10-1Z, 20-2Z, etc.

             The CID number appears on each page of the manuscript. The complete citation is used on the first page, and an
             abbreviated version on subsequent pages.

                                                                                                                                                         iii

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SESSION 3          NANOPARTICLE-BASED IMAGING I

                     64470E         Multifunctional nanoparticles for drug/gene delivery in nanomedicine (Invited Paper)
                                    [6447-13]
                                    M.-M. Seale, D. Zemlyanov, C. L. Cooper, E. Haglund, Purdue Univ. (USA); T. W. Prow, Johns
                                    Hopkins Univ. (USA); L. M. Reece, J. F. Leary, Purdue Univ. (USA)

                     64470H         Enhanced gold nanoshell scattering contrast in cervical tissue using angled fiber probes
                                    [6447-16]
                                    V. Nammalvar, A. Wang, R. Drezek, Rice Univ. (USA)

                      64470I        NAOMI: nanoparticle-assisted optical molecular imaging [6447-17]
                                    D. J. Faber, M. de Bruin, M. C. G. Aalders, F. D. Verbraak, Academic Medical Ctr.
                                    (Netherlands); T. G. van Leeuwen, Academic Medical Ctr. (Netherlands) and Univ. of
                                    Twente (Netherlands)

                 SESSION 4          NANOPARTICLE-BASED IMAGING II

                     64470J         In-plane photonic transduction for microcantilever sensor arrays (Invited Paper) [6447-18]
                                    G. P. Nordin, J. W. Noh, S. Kim, Brigham Young Univ. (USA)

                     64470K         Optical biosensor based on silicon-on-insulator microring cavities for specific protein
                                    binding detection [6447-19]
                                    K. M. De Vos, I. Bartolozzi, P. Bienstman, R. Baets, E. Schacht, Univ. Gent (Belgium)

                     64470L         Four-channel optical detection on protein-patterned bioCD [6447-20]
                                    X. Wang, M. Zhao, D. D. Nolte, Purdue Univ. (USA)

                     64470M         Investigation of the operating mechanism of a diffraction-based biosensor [6447-22]
                                    J. Valiani, M. F. Paige, Univ. of Saskatchewan (Canada)

                     64470O         Nanostructured porous polymeric photonic bandgap structures for sensing (Invited Paper)
                                    [6447-24]
                                    S. J. Kim, Univ. at Buffalo, The State Univ. of New York (USA); V. P. Chodavarapu, McGill
                                    Univ. (Canada); R. Bukowski, A. H. Titus, A. N. Cartwright, M. T. Swihart, F. Bright, Univ. at
                                    Buffalo, The State Univ. of New York (USA); T. J. Bunning, Air Force Research Lab. (USA)

                     64470P         Sensitivity analysis of a photonic crystal structure for index-of-refraction sensing [6447-25]
                                    O. Levi, M. M. Lee, Stanford Univ. (USA); J. Zhang, Ctr. for High Technology Materials, Univ.
                                    of New Mexico (USA); V. Lousse, Stanford Univ. (USA); S. R. J. Brueck, Center for High
                                    Technology Materials, Univ. of New Mexico (USA); S. Fan, J. S. Harris, Stanford Univ. (USA)

                                    POSTER SESSION

                     64470Q         The investigation of the subwavelength focusing spot resulting from modified surface
                                    plasmon wave at planar interface [6447-11]
                                    J.-N. Yih, National Kaohsiung Univ. of Applied Sciences (Taiwan); S.-J. Chen, S.-T. Hong,
                                    National Cheng Kung Univ. (Taiwan); H.-F. Yau, National Central Univ. (Taiwan)

                iv

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64470R         Sensitivity enhancement of fiber optic biosensor by localized surface plasmon-coupled
                                    emission with gold nanoparticles [6447-21]
                                    Y.-F. Chang, National Central Univ. (Taiwan); B.-Y. Hsieh, H.-Y. Chen, National Yang Ming
                                    Univ. (Taiwan); M.-Y. Ng, W.-C. Liu, National Taiwan Normal Univ. (Taiwan); Y.-C. Chung,
                                    H.-T. Wu, National Yang Ming Univ. (Taiwan); C. Chou, National Central Univ. (Taiwan) and
                                    National Yang Ming Univ. (Taiwan)

                     64470S         Colloid-gold nanoparticle enhanced detection sensitivity of paired surface plasma waves
                                    biosensor [6447-26]
                                    H.-T. Wu, Y.-L. Chen, Y.-C. Huang, National Yang Ming Univ. (Taiwan); W.-C. Liu, M.-Y. Ng,
                                    National Taiwan Normal Univ. (Taiwan); Y.-F. Chang, National Central Univ. (Taiwan);
                                    B.-Y. Hsieh, National Yang Ming Univ. (Taiwan); C. Chou, National Yang Ming Univ. (Taiwan)
                                    and National Central Univ. (Taiwan)

                                    Author Index

                                                                                                                                 v

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Conference Committee

                              Symposium Chairs
                                                James G. Fujimoto, Massachusetts Institute of Technology (USA)
                                                Richard R. Anderson, Wellman Center for Photomedicine (USA),
                                                  Massachusetts General Hospital (USA), and Harvard School of Medicine
                                                  (USA)

                              Program Track Chairs
                                                Paras N. Prasad, University at Buffalo, State University of New York (USA)
                                                Dan V. Nicolau, The University of Liverpool (United Kingdom)

                              Conference Chairs
                                                Alexander N. Cartwright, University at Buffalo, State University of New York
                                                  (USA)
                                                Dan V. Nicolau, The University of Liverpool (United Kingdom)

                              Cochair
                                                Paul L. Gourley, Sandia National Laboratories (USA)

                              Program Committee
                                                Igal Brener, Sandia National Laboratories (USA)
                                                Philippe M. Fauchet, University of Rochester (USA)
                                                Piotr Grodzinski, Los Alamos National Laboratory (USA)
                                                Brian McGraith, Dublin City University (Ireland)
                                                Igor L. Medintz, Naval Research Laboratory (USA)
                                                Ammasi Periasamy, University of Virginia (USA)
                                                Paras N. Prasad, University at Buffalo, State University of New York (USA)
                                                Weihong Tan, University of Florida (USA)

                              Session Chairs
                                       1        Micro- and Nanosensors I
                                                Alexander N. Cartwright, University at Buffalo, State University of New York
                                                 (USA)

                                       2        Micro- and Nanosensors II
                                                Alexander N. Cartwright, University at Buffalo, State University of New York
                                                 (USA)

                                                                                                                               vii

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3        Nanoparticle-based Imaging I
                                                Paul Dan A. Cristea, University Politehnica Bucharest (Romania)

                                       4        Nanoparticle-based Imaging II
                                                Dan V. Nicolau, The University of Liverpool (United Kingdom)

                viii

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