MINDS AT WORK Special Research Issue - GAINING ON CANCER - Emory University
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WINTER 2018 MAGAZINE VO L . 9 3 N O. 3 MINDS AT WORK Special Research Issue G A I N I NG ON C A NC E R H A LT I NG H A BI TAT DE ST RUCT ION T R AV E L I NG I N T I M E E XT E N DI NG BRA I N H E A LT H SUSTA I N I NG GR E AT SCHOLA R SH I P
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C O N T E N TS Emory Magazine Vol. 93 No. 3 RESEARCH ISSUE 22 All In the Mind An unexpected discovery leads Emory scientists to new understanding of the pathology behind Alzheimer’s and Parkinson’s diseases. 22 By Gary Goettling 44 28 Fabulous Five 44 Meet a few of the Emory faculty members who just can’t stop asking questions—and won’t stop until they find the answers. 38 38 Hanging by a Thread As the world’s primate populations dwindle, so do the chances for a healthy planet where humans can thrive. By Tony Rehagen 32 32 28 Outpacing Cancer Our Own Indiana Jones PHOTOGRAPHY ML AB, WINSHIP: STEPHEN NOWL AND; PA P E R S : K AY H I N TO N ; G I L L E S P I E : K AY H I N TO N Winship Cancer Institute How an undergraduate student scientists and physicians are turned a seminar class into a in a tight race with the second- research project that traces the highest cause of death in the US— post-WWI path of an Emory and they mean to win. professor-turned-adventurer. By Sylvia Wrobel By Scott Henry
C O N T E N TS 10 49 POINTS OF INTEREST 11 Editor Director Paige P. Parvin 96G of Creative Services 6 TWENTIETH Alex Bundrick RHODES SCHOLAR Associate Editor Maria M. Lameiras Design Gordon Boice 8 SHORT LIST Executive Director Stanis Kodman of Communication Susan Carini 04G Photography 9 BOARD OF TRUSTEES Ann Borden LEADERSHIP Contributors Kay Hinton Carol Clark Stephen Nowland Elizabeth Cobb Durel 10 SHAPE-SHIFTING Quinn Eastman Production Manager PARTICLES EMORY EVERYWHERE Gary Goettling Stuart Turner Scott Henry April Hunt Interim Senior 12 TWITTER, MEET BIG DATA 49 ALUMNI HONORED Tony Rehagen Vice President, EMORY MEDALISTS 2018 Kimber Williams Communications 14 AN ETHNOBOTANIST Sylvia Wrobel and Public Affairs Vincent Dollard PLUMBS PLANT POWER 52 CLASS NOTES Copy Editor Jane Howell University President 16 GUIDING GLOBAL 56 ALUMNI IN RESEARCH Claire E. Sterk HEALTH ETHICS 59 CODA 18 NEW PROJECT TO STUDY EPIDEMIC DILEMMA P H O T O G R A P H Y B U R TO N : E M O R Y P H OTO/ V I D E O ; S T U D E N T: K AY H I N TO N : N U R S E S : J A C K K E A R S E VEHICLE SAFETY EMORY MAGAZINE (ISSN 00136727) is published quarterly by Emory’s Division of Communications and Public Affairs. Non- profit postage paid at 3900 Crown Rd. SE, Atlanta, Georgia, 20 HELPING ADDICTS 30304; and additional mailing offices. POSTMASTER: Send address changes to OFFICE OF ALUMNI AND DEVELOPMENT KICK THE HABIT RECORDS, 1762 Clifton Road, Suite 1400, Atlanta, Georgia 30322. Emory Magazine is distributed free to alumni and friends of the university. Address changes may be emailed to eurec@ emory.edu or sent to the Office of Alumni and Development Records, 1762 Clifton Road, Suite 1400, Atlanta, Georgia MORE ONLINE AT EMORY.EDU/MAGAZINE 30322. If you are an individual with a disability and wish to acquire this publication in an alternative format, please contact Paige Parvin (address above) or call 404.727.7873. V I D EO : L I F E L E SS PA RT I C L E S B EC O M E “L I F E- L I K E” No. 18-EU-EMAG-0040 ©2018, a publication of the Division Watch how particles collectively switch back and forth between of Communications and Public Affairs. states—even when the environment remains stable. The comments and opinions expressed in this magazine do not necessarily represent those of Emory University or the V I D EO : W H AT N C I C O M P R E H E N S I V E D E S I G N AT I O N M E A N S PHOTOGRAPHY STEPHEN NOWL AND staff of Emory Magazine. Winship is changing the way cancer is treated. V I D EO : A L Z H E I M E R’S STO RY A unique program reaches at-risk populations. ON THE COVER Illustration by Carlos Coelho at Infomen. 2 EMORY MAGAZINE WINTER 2018
a P R E LU D E As I drive onto the Emory campus each The faculty and students featured in breaking work in Madagascar has built morning, I can’t help but marvel a little. this magazine are here because they are new awareness around the urgent need This is an impressive place. Its build- relentlessly curious, instinctive think- for conservation, since it seems humans ings are beautiful, its resources plen- ers, compelled to question and driven and animals swap germs a lot more easily tiful, its setting lovely and well kept, its to pursue answers. And they don’t hesitate and often than we previously thought. facilities state of the art. And it’s forever to cross the lines of academic disci- There’s David Katz, a cell biologist busy; its streets and sidewalks are literally plines to put their heads together with who accidentally discovered a gene func- never still, and at night, its windows are fellow scholars. tion that could help ward off diseases a constantly changing constellation of There’s Andrew Hoover 20C, an like Alzheimer’s before they start. lights. Within a thousand walls, it buzzes undergraduate premed major who was There’s Joseph Crespino, a history and clicks, whirs and sputters and hums, so intrigued by the 1920s-era diaries of professor who mined thousands of pages a million circuits aglow with signals. Emory professor and traveler William of newspapers and letters in his deep re- Of course, somebody has to keep all Shelton that he took a detour from his search for a fictional biography of Atticus those lights on, and Emory is fortunate neuroscience and behavioral biology Finch; and Erin Tarver, an assistant pro- to attract its share of funding—including classes to explore, creating an interactive fessor at Oxford who brings the weight many generous gifts and grants that sup- website that traces Shelton’s steps. of classical philosophy to her analysis of port both the university’s infrastructure There’s Rafi Ahmed, a renowned im- professional sports. and the work being done within it. munologist who was parsing out how As far as I know, there is no formula This issue of Emory Magazine is filled T cells respond to chronic infection for calculating the worth of individual, with examples. when it became clear that his research original thought. But the mysterious pro- Every element of this framework is had major implications for cancer cesses and connections that spark and valuable and important to the univer- treatments, too. He’s now collaborating catch fire every day, quietly and invisibly, sity’s mission. But in this special issue with Winship researchers and making inside the heads of Emory’s faculty and devoted to research, the spotlight shines progress toward a clinical trial. students are the truest natural resource brightest on another, less tangible, more There’s Thomas Gillespie, an environ- that universities have. That’s what really vital resource: minds at work. mental scientist whose gritty, ground- keeps the lights on.—Paige Parvin 96G P H O T O G R A P H Y B U R TO N : E M O R Y P H OTO/ V I D E O ; S T U D E N T: K AY H I N TO N : N U R S E S : J A C K K E A R S E 1 RO O M TO T H I N K The Stuart A. Rose Manuscript, Archives, and Rare Book Library In this special research issue, we visit a series of spaces where learning, discovery, and inspiration take place every day. PHOTOGRAPHY STEPHEN NOWL AND The Rose Library’s wide-ranging collections are open to anyone pursing scholarly or personal research. WINTER 2018 EMORY MAGAZINE 3
L E T T E RS AU T U M N 2 0 17 MAGAZINE VO L . 9 3 N O. 2 Written e? In Bone An Emory anthropologist made history when she unearthed the oldest-known DNA from Africa NOW WE’RE COOKING Atlanta Chef Linton Hopkins 92C ...makes his own butter INNOVATIONS IN UNDERGRADUATE EDUCATION THE ARTICLE “THIS ACTION IS Inevitable” (summer 2017) about women at Emory reminded me of the story of Marjorie Gates, my mother. She had completed two years at Agnes Scott and applied to transfer to Emory in 1939. When she was interviewed by the university president, he asked her if she wanted to come to Emory to get her “MRS” degree (that is, find a husband). She said Emory had a better chemistry depart- ment than Agnes Scott, it had a payment plan, and she could ride to school with her brother, an Emory student. From Emory, she received a bachelor’s degree in 1940, a master’s degree in 1943, and (finally) an “MRS” in 1943, by marrying Dr. R. A. Day Jr., an Emory professor. Together, they raised four children, all of whom received degrees from Emory. Footnote: She did her graduate research under the direction of Dr. Evange- line Papageorge, mentioned in the article. Michael A. Day 69C Pine Lake What do you think? The editors of Emory Magazine welcome letters from our readers. Write to us at paige.parvin@emory.edu, or 1762 Clifton Rd., Suite 1000, Atlanta, Georgia, 30322. We reserve the right to edit letters for length and to correct style as needed. The views expressed by the writers do not nec- essarily reflect the views of the editors or the PHOTOGRAPHY STEPHEN NOWL AND administration of Emory University. 4 EMORY MAGAZINE WINTER 2018
2 RO O M TO T H I N K Parsons Conservation Laboratory Located in the basement of the Michael C. Carlos Museum, this is where conservators examine, document, and repair objects such as this Egyptian funerary mask and Hittite house model in preparation for exhibition or loan. PHOTOGRAPHY STEPHEN NOWL AND WINTER 2018 EMORY MAGAZINE 5
P O I N TS O F I N T E R E ST Turning Ideas to Ideals EMORY’S TWENTIETH RHODES SCHOLAR INTENDS TO IMPROVE THE CRIMINAL JUSTICE SYSTEM Chelsea Jackson 18C is one of thirty-two American college students selected as a 2018 Rhodes Scholar. Jackson, a political science and African Ameri- can studies double major in Emory College of Arts and Sciences, is the universi- ty’s twentieth student to be selected for the prestigious scholarship, which supports two to three years of study at the University of Oxford in England. She also is the fourth woman and the first African American student from Emory to receive the scholarship. “I am immediately blessed to be selected,” says Jackson, who is from Lithonia, Georgia. “Just the resources available and the opportunity to live outside ACTIVIST HEART Rhodes Scholar Chelsea Jackson will study criminology at Oxford University, which has a research the US and interact and center focused on the sociology of criminal justice. She wants to examine ways to reform the criminal justice system by, learn from scholars through- for instance, reducing the use of solitary confinement and expanding maternal rights for incarcerated women. out the world is immense.” Jackson has focused her undergraduate research and her community leadership Jackson has been heavily involved with the Emory chapter on efforts to create a more equitable campus and Atlanta of the NAACP and cofounded the Atlanta Black Students Unit- community. ed (ATLBSU), a group with black student representatives from “Chelsea is a passionate and committed student who uses every school in metro Atlanta. The ATLBSU serves as a vital her intellectual talents and commitment to social justice to support system for students and a resource for allies. PHOTOGRAPHY ANN BORDEN P H O T O G R A P H Y K AY H I N TO N better our world,” says President Claire E. Sterk. “She will be a Last year, she shifted from working as the group’s media wonderful ambassador for the United States and Emory as she representative to putting additional energy into her academic continues her work at Oxford University.” commitments. 6 EMORY MAGAZINE WINTER 2018
She presented a conference paper with an abundance of brain power last year with her adviser, Andra and the willingness to do the work to Gillespie, associate professor of polit- develop her skills. Her keen intellect ical science and director of Emory’s CHELSEA’S KEEN and commitment to public service and James Weldon Johnson Institute for INTELLECT AND social justice make her the student you the Study of Race and Difference. The COMMITMENT TO dream of having the honor to teach.” project explores how different back- PUBLIC SERVICE AND Jackson plans to earn a master’s stories influence public opinion when SOCIAL JUSTICE MAKE degree in criminology at Oxford, home it comes to police shootings. She also HER THE STUDENT YOU to a cutting-edge research center that was named Emory’s first Truman DREAM OF HAVING THE focuses on the sociology of criminal Scholar since 2011. HONOR TO TEACH. justice. She hopes to examine how the “Chelsea truly embodies the ideals law can be used to reform the criminal of liberal arts and sciences education. justice system by—for example—re- Her pursuit of knowledge and inquiry ducing the use of solitary confinement informs her activism and her dedica- and expanding the maternal rights of tion to making our society a more just incarcerated women. one for all,” says Michael Elliott, dean “I want to learn how race and poli- of Emory College and Charles Howard tics play out in other countries’ crimi- Candler Professor of English. “We are extremely proud of her, nal justice systems to see how that shapes their worldview, and and I am looking forward to watching her career unfold as she to consider new ideas and ways to solve problems that I have leaves our campus to have an impact on the world beyond it.” not thought of yet,” Jackson says. This year, Jackson is focused on her master’s thesis as After completing her Oxford degree, she plans to return to Emory’s sole BA/MA candidate in political science. Her topic: the US to attend law school to become a civil rights attorney, examining whether the race of the prosecutor can affect racial either with the Department of Justice or a broad-reaching discrepancies in the criminal justice system when looking at nonprofit focused on social justice. matters of discretion, such as whether to charge the accused “The more empirical ideas I can learn, the more I can see with a felony or misdemeanor. how things are done elsewhere, the more I can be a better ac- “Chelsea is brilliant,” Gillespie says. “She came to Emory tivist and propose better solutions,” Jackson says.—April Hunt City Life annexation, we will pursue our shared mission of serving Emory’s annexation into Atlanta approved the common good in the greater metropolitan area and well beyond.” The City of Atlanta and Emory announced in early Decem- Emory and the City of Atlanta have built alliances over ber that the annexation of Emory had been approved by the many years. In addition to Emory University Hospital Mid- City Council, effective January 1, 2018. town and Emory’s historical affiliations with Grady Hospital “Working together, Emory and the City of Atlanta will and the Morehouse School of Medicine, Georgia Tech and continue building a stronger future for neighborhoods Georgia State, Emory’s stewardship of and investments in across the metropolitan area,” says President Claire E. key business, arts, culture, and scholarship resources drive Sterk. “We enter this new stage of our relationship with economic activity to the region. enthusiasm and great optimism for what lies ahead. “Emory and the city are entering an exciting new phase “Emory is not leaving DeKalb County,” adds Sterk. in their shared history and development,” says Robert God- “We remain steadfastly committed to our colleagues and dard, chair of the Emory Board of Trustees. “Our collabora- neighbors in county leadership and beyond. Alongside tive partnership will help Emory strengthen its commitment the Centers for Disease Control and Prevention, Children’s as a leading liberal arts research university to improving Healthcare of Atlanta, and the other entities involved in society on a local, national, and international scale.” PHOTOGRAPHY ANN BORDEN P H O T O G R A P H Y K AY H I N TO N
SHORT LIST Georgia research universites to share space All eight universities in the Georgia Research Alliance (GRA) will now $73.5M share the use of core research facilities at each of their institutions. The aim of the partnership agreement is to create a greater availability of research support services for faculty at all Georgia research universities, minimize duplication of resources, and maximize collaborative research opportu- Emory Healthcare helps the nities. GRA institutions include Emory, UGA, Morehouse patients who need it most School of Medicine, Mercer, Georgia State, Georgia Tech, Emory Healthcare provided $73.5 million in charity Clark Atlanta University, and Augusta University. care in fiscal year 2017, reaching patients with no health insurance, including Medicare or Medicaid, Emory leaders named as influencers and no resources of their own. The term also includes Emory President Claire E. Sterk and Emory Health- catastrophic care for patients who may have some care chair, president, and CEO Jonathan Lewin were coverage but for whom health care bills are among Georgia Trend magazine’s one hundred “Most devastating. During this same time, Emory Influential Georgians,” made up of leaders “who have medical faculty also provided $24.6 exhibited the character necessary to inspire, chal- million in unreimbursed care at lenge, lead, and influence us.” Doug Shipman 95C, Grady Memorial Hospital. president and CEO of the Woodruff Arts Center, also made the 2018 list. Emory Professor wins Justice at Emory Law Japan Prize Sonia Sotomayor, associate justice of Emory Professor Max D. the US Supreme Court, visited the Cooper was named a laureate of School of Law on February 6, partic- the 2018 Japan Prize for the discov- ipating in a Q&A with Professor Fred ery of the dual nature of adaptive Smith Jr., who clerked for her during immunity, which identified the the October 2013 term. Sotomayor cellular building blocks of the advised the rapt audience to engage immune system as we understand fully in civic life. “Otherwise, we will be it today. The annual awards recog- nothing but bystanders,” she warned. nize pioneers in medicinal science “Every one of us is here to make a contribu- and resources, energy, and envi- tion, but you have to have the heart to do it.” ronment and social infrastructure. Cooper is one of three scientists recognized this Emory nursing graduates get a pass year for achievements Recent graduates of the Nell Hodgson Woodruff School of Nursing contributing to the advancement of science Accelerated Bachelor of Science in Nursing (ABSN) program and technology and promoting peace and achieved a 100 percent pass rate on the NCLEX national prosperity for all mankind. licensure exam, making it one of the top-performing ABSN programs in the nation. The school was ranked No. 4 nationally in the US News and World Report Best Graduate Schools guide and No. 1 in NIH funding among nursing schools. Give stroke patients more time Although current guidelines suggest clot removal only within six hours of stroke onset, PHOTOGR APHY ELLMAN N: STEPH EN NOWL AN D; GOD DARD: AN N BORD EN a study published in the New England Journal of Medicine shows that clot removal up to twenty-four hours after a stroke led to significantly reduced disability for some patients. Of 206 Emory stroke patients who randomly received experiment to board either endovascular clot removal therapy International Space Station or standard therapy of clot-busting Researchers at Emory School of medication, almost half of those who Medicine and Children’s Healthcare of had clot removal showed a considerable Atlanta have been awarded a two-year grant from the Center for the decrease in disability, compared to Advancement of Science in Space supporting their work enhancing the abil- 13 percent of the medication group. ity of pluripotent stem cells to turn into cardiac muscle cells. Now the cells they’ve carefully cultured will be tested on the International Space Station. Stem cell–derived cardiac muscle cells have been used to treat heart failure in animal models and to study inherited cardiac diseases separately from the heart of the source patient. 8 EMORY MAGAZINE WINTER 2018
P O I N TS O F I N T E R E ST ‘Twisted New Board Roots and of Trustees Branches’ Chair ELLMANN LECTURES TRACE FAMILY TIES Robert Goddard T Emory’s Board of Trustees has elected busi- he 2017 Ellmann Lectures, given by acclaimed Irish author Colm ness executive Robert Goddard III to serve Tóibín in November, turned on the subject of familial inher- as its new chair. The resolution passed at the itance—or what Geraldine Higgins, codirector of the lecture full board’s annual meeting in November. series, calls “all the twisted roots and branches of the family tree.” Goddard, who has served as a trustee Tóibín’s subject was also personal, for he lost his own father when since 2008 and as vice chair of the board he was twelve and told a Guardian reporter in 2014, “Every writer has since 2016, succeeds John Morgan 67OX something in their childhood that nurtures them while seeming to be 69B, who is retiring as chair after serving in very damaging at the time.” the role since 2013 and as an Emory trustee During the course of three lectures, Tóibín examined the lives and since 1996. Morgan will remain active as an relationships of Oscar Wilde, James Joyce, and W. B. Yeats with their emeritus trustee. fathers. He began with the scandalous libel suit Oscar Wilde brought “Bob Goddard is a dynamic, thoughtful, against John Douglas, the Ninth Marquess of Queensberry, after the and creative leader who understands the latter—enraged over the affair between Wilde and his son, Lord Alfred breadth and depth of Emory’s strengths and “Boisie” Douglas—left an accusing card in plain view at Wilde’s club. responsibilities as a leading research univer- After a libel suit against his mother when Wilde was a child, the sity,” says Emory President Claire E. Sterk. family maintained its social status. Based on this experience, Tóibín “His collaborative approach and his commit- observed, Wilde “seriously misjudged how the judge, jury, and public ment to our faculty, students, patients, and would view him.” Despite being the toast of London in 1895, when The alumni make him a compelling leader of, and Importance of Being Earnest was entertaining audiences, Wilde would advocate for, Emory University.” lose his trial, be sentenced to two years of hard labor, and fall out of Goddard is chairman and CEO of God- favor with the public. dard Investment Group, a privately held firm Tóibín took on the father of poet W. B. Yeats, John Butler Yeats, who investing in commercial real estate, primarily abandoned his family to pursue life as a painter, only to have his success in Atlanta, Dallas, Denver, Houston, Miami, eclipsed by his sons, W. B. as a poet and Jack as a painter. Says Tóibín, and Washington, D.C. “the father’s exile was enabling and inspiring for the son’s work.” “One of the qualities that sets Emory In the final lecture, Tóibín characterized James Joyce’s father apart is our commitment to working togeth- PHOTOGR APHY ELLMAN N: STEPH EN NOWL AN D; GOD DARD: AN N BORD EN as incapable of managing the family finances and was, according to er to transform society on a local, national, James’s brother Stanislaus, “a man of absolutely unreliable temper.” and international scale,” says Goddard. “I see Despite this, the elder Joyce would inspire his son’s work. “Hun- that commitment across the university, from dreds of pages, and scores of characters in my books, came from him. our colleges and graduate and professional I got from him his portraits, a waistcoat, a good tenor voice, and an schools, to our research and health care en- extravagant, licentious disposition, out of which, however, the great- terprises, each of which draws people from er part of any talent I may have springs,” Joyce wrote to his mentor, all over the world.” T. S. Eliot. Goddard, who holds a bachelor’s degree Tóibín concluded, “instead of openly killing his father, James Joyce in economics from Mercer University, grad- sought not only to memorialize him but . . . use what he needed from uated from Harvard University’s Owners and his father’s life to nourish his own art.”—Susan Carini 04G Presidents Management program. WINTER 2018 EMORY MAGAZINE 9
P O I N TS O F I N T E R E ST Many living systems—from fireflies to over time if I set the parameters of the neurons—switch behaviors collectively, chamber at a low gas pressure, enabling firing on and then shutting off. But the them to move freely,” Gogia says. “After current paper involved a nonliving sys- a few minutes I could see with my naked tem: Plastic particles, tiny as dust specks, eye that they were acting strangely.” that have no “on” or “off” switches. From anywhere between tens of “The individual particles cannot seconds to minutes, the particles would change between crystalline and fluid switch from moving in lockstep, or a Particles states,” Burton says. “The switching emerges when there are collections of rigid structure, to being in a melted gas-like state. It was surprising because Gone Wild these particles—in fact, as few as forty. the particles were not just melting and Our findings suggest that the ability for a recrystallizing but going back and forth system to switch behaviors over any time between the two states. scale is more universal than previously “Imagine if you left a tray of ice out WATCHING HOW PARTICLES thought.” on your counter at room temperature,” SWITCH STATES COULD REALLY Burton’s lab studies the tiny, plastic Gogia says. “You wouldn’t be surprised SHAKE PHYSICS UP particles as a model for more complex if it melted. But if you kept the ice on the systems. They can mimic the properties counter, you would be shocked if it kept A system of lifeless particles can become of real phenomena, such as the melt- turning back to ice and melting again.” “lifelike” by collectively switching back ing of a solid, and reveal how a system Gogia conducted experiments to con- and forth between crystalline and fluid changes when it is driven by forces. firm and quantify the phenomenon. The states—even when the environment The particles are suspended in a vacu- findings could serve as a simple model remains stable. um chamber filled with a plasma-ionized for the study of emerging properties in Particles may be small, but in the argon gas. By altering the gas pressure nonequilibrium systems. field of physics, this is huge. inside the chamber, the lab members can “Switching is a ubiquitous part of our Physical Review Letters recently pub- study how the particles behave as they physical world,” Burton says. “Nothing lished the findings by Emory physicists, move between an excited, free-flowing stays in a steady state for long—from the first experimental realization of such state into a jammed, stable position. the earth’s climate to the neurons in a dynamics. “We’ve discovered perhaps The current discovery occurred after human brain. Understanding how sys- the simplest physical system that can Emory graduate student Guram “Guga” tems switch is a fundamental question consistently keep changing behavior Gogia 22PhD tapped a shaker and slowly in physics. Our model strips away the over time in a fixed environment,” says “salted” the particles into the vacuum complexity of this behavior, providing Justin Burton, assistant professor of chamber filled with the plasma, creat- the minimum ingredients necessary. physics. “In fact, the system is so simple ing a single layer of particles levitating That provides a base, a starting point, to we never expected to see such a complex above a charged electrode. “I was just help understand more complex systems.” property emerge from it.” curious how the particles would behave —Carol Clark Nothing stays in a steady state for long—from the earth’s climate to the neurons in a human brain. P H O T O G R A P H Y E M O R Y P H OTO/ V I D E O P H O T O G R A P H Y K AY H I N TO N Justin Burton 10 EMORY MAGAZINE WINTER 2018
A MAT TER OF DEGREE The Mellon Mays Undergraduate Fellowship program puts doctorates within reach for minority students A n Emory program that expands opportunities for under- pipeline has a profound impact on knowledge production, the represented minorities to earn doctorates and faculty retention of a diverse student body, and the intellectual strength positions has received renewed funding from the Andrew that diversity brings to academic communities, Anderson says. W. Mellon Foundation. “This is why we do this work. Because of the initial leadership of Emory’s Mellon Mays Undergraduate Fellowship (MMUF) pro- the late professor Rudolph Byrd and then professor Dianne Stewart, gram will receive $131,000 for the current year. Emory selects its the MMUF program at Emory is, without question, first rate,” Ander- own fellows, rising juniors in Emory College with demonstrated son says. “Our fellows are completing their doctorates at Harvard, academic excellence and serious intent to pursue a doctoral Northwestern, Michigan, Brown, Rutgers, and more. They are the degree in selected humanities and social sciences. recipients of major fellowships, including the Fulbright.” “As we prepare our diverse student body to contribute as scholars and thought leaders in the academy and beyond, we are committed to sustaining an environment at Emory that promotes full participation and inclusivity. The MMUF program provides an ideal platform to advance this objective and to support our students as they pursue their education and devel- opment as thought leaders with diverse intellectual interests and perspectives,” says Dwight McBride, provost and executive vice president for academic affairs. The latest grant will pay stipends and research support to ten junior and senior fellows during the academic year. The Mellon Foundation also provides funding to culti- vate the kind of social capital— SERIOUS STUFF The Mellon Mays program pre- mentoring, pares the next generation of college professors, helped grant writing, by leaders like Cynthia Neal Spence (left), UNCF/Mellon programs director at Spelman College. conference presentations, how-to-publish workshops— Since the 1990s, Emory also has served as that often makes the formal launching point annually for 106 the critical differ- fellows by hosting the UNCF/Mellon Summer ence in gradu- Institute, which introduces the newly selected ate school and students to life as an academic. In addition to faculty success. Emory, they come from colleges across the “MMUF is essential,” says Carol Anderson, Charles Howard country as well as two universities in South Africa. Candler Professor and chair of the Department of African Amer- Fellows in the four-week immersion institute attend lectures ican Studies, who leads the Emory program. “The glaring lack of on topics such as research, work-life balance, and the art and diversity in the professoriate is evident across the United States, philosophy of teaching, as well as engage in weekly writing where, for example, Hispanic males comprise only 2 percent of exercises to hone their critical thinking and analysis abilities. all tenure-track faculty. The numbers are nearly as low or lower They also create a prospectus that forms the foundation for a for African American and Native American men and women, as two-year research project with faculty mentors. well as Hispanic women.” The summer program prepares fellows for the MMUF, which, Since it was established in 1988, MMUF has supported 762 in addition to stipends, provides each cohort with ongoing P H O T O G R A P H Y E M O R Y P H OTO/ V I D E O PhD graduates. Emory, which joined the program in 2000, has mentoring, research support, and professional guidance from launched seven so far, many of whom are now in tenure-track faculty, coordinators, and graduate students. P H O T O G R A P H Y K AY H I N TO N positions, along with several former students currently in gradu- Fellows enrolled in PhD programs up to thirty-nine months ate programs pursuing doctorates. after earning a bachelor’s degree are also eligible for up to Bringing more underrepresented students into the doctoral $10,000 in loan forgiveness.—April Hunt WINTER 2018 EMORY MAGAZINE 11
P O I N TS O F I N T E R E ST # I See the Future Using Twitter and big data tools to read minds—many, many minds People who think farther into the future are more likely to invest money and to avoid risks, accord- ing to new findings by Emory psychologists. While that conclusion may not seem reve- latory, previous findings on the subject have been inconsistent—possibly due to factors such as observer son is that prior studies explicitly asked individuals how far bias in a lab setting and small sample sizes. What’s notable they thought into the future, while the PNAS paper used the about this research, published by the Proceedings of the implicit measure of previous tweets. National Academy of Sciences (PNAS), is that it tapped big The researchers used a suite of methods to automatical- data tools to conduct text analyses of nearly forty thousand ly analyze Twitter text trails previously left by individual Twitter users and to run online experiments of behavior of subjects. Experimental data was gathered using the Ama- people who provided their Twitter handles. zon crowdsourcing tool Mechanical Turk, a website where “Twitter is like a microscope for psychologists,” says individuals can complete psychology experiments and other coauthor Phillip Wolff, associate professor of psychology. internet-based tasks. “Naturalistic data mined from tweets ap- In one experiment, Mechanical Turk par- pears to give insights not just into tweet- ticipants answered a classic delay discount- ers’ thoughts at a particular time, but into ing question, such as: Would you prefer $60 a relatively stable cognitive process. Using today or $100 in six months? social media and big-data analytical tools Twitter is like a The participants’ tweets were also opens up a new paradigm in the way we study human behavior.” microscope for analyzed. Future orientation was measured by the tendency of participants to tweet Coauthor Robert Thorstad 16G 22PhD, psychologists.” about the future compared to the past. a grad student in the Wolff lab, came up Future-sightedness was measured based on with the idea for the research, worked on how often tweets referred to the future, and the design and analyses, and conducted the how far into the future. experiments. The results showed that future orientation was not asso- “I’m fascinated by how peoples’ everyday behavior can ciated with investment behavior, but that individuals with give away a lot of information about their psychology,” far-future-sightedness were more likely to choose to wait Thorstad says. “Much of our work was automated, so we for future rewards than those with near-future-sightedness. were able to analyze millions of tweets from thousands of That indicates that investment behavior depends on how far individuals’ day-to-day lives.” individuals think into the future, rather than their tendency The future-sightedness found in individuals’ tweets was to think about the future in general. PHOTOGRAPHY STEPHEN NOWL AND short—usually just a few days—which differs from prior re- “Twitter can provide a much broader participant pool search suggesting future-sightedness may stretch years. than many psychology experiments that primarily use under- “One possible interpretation is that the difference is due graduates as subjects,” Thorstad says. “Big data methods may to a feature of social media,” Wolff says. Another possible rea- ultimately improve generalizability for psychology results.” 12 EMORY MAGAZINE WINTER 2018
CHEMISTS UNITE EMORY’S CCHF CONNECTS UNIVERSITIES AND INDUSTRIES TO ADVANCE INNOVATION IN ORGANIC CHEMISTRY T he National Science Foundation making it faster and more efficient. has awarded another $20 million The CCHF is not only transforming to Emory’s Center for Selective WE’VE GOT THIS INCREDIBLE organic synthesis—it’s also creating new C-H Functionalization (CCHF) to fund the models for the way organic chemistry is COLLABORATIVE ENVIRON- next phase of a global effort to revolution- taught and how labs conduct research. ize the field of organic synthesis. MENT WHERE ORGANIC Where previously individual labs tended “Our center is at the forefront of a ma- CHEMISTS AREN’T to work in isolation to tackle problems, jor shift in the way that we do chemistry,” JUST SHARING RESULTS, the CCHF has broken down walls across says Huw Davies, professor of chemistry specialties, institutions, and even countries THEY’RE SHARING IDEAS. and the director of the CCHF. “This shift to collectively take on the remaining chal- holds great promise for creating new THAT’S RARE. lenges of selective C-H functionalization. pathways for drug discovery and the “We’ve got this incredible collaborative production of new materials to benefit ev- tionalization flips this model on its head. environment where organic chemists aren’t erything from agriculture to electronics.” “We’ve devised ways to make C-H just sharing results—they’re sharing ideas,” The CCHF began in 2009 as an NSF bonds react so that they become func- Davies says. “That’s rare. And we’ve expand- Center for Chemical Innovation, with a tional,” Davies says. “And we’ve reached ed beyond our network of universities to seed grant of $1.5 million and four col- the stage where it is no longer the molecule also engage the pharmaceutical industry.” laborating universities. In 2012, the NSF awarded the CCHF its first $20 million, Huw Davies enabling it to grow to encompass sixteen US institutions and seven industrial affili- ates, including six major pharmaceutical companies and one of the largest US chemical suppliers. The center also built global connections with major players in C-H functionalization in Japan, South Korea, and the UK. The CCHF has led the way for explosive growth in the field of C-H functionalization, publishing more than two hundred papers on the topic through its collaborators. It has developed dozens of new catalysts for C-H functionalization, including four major classes from the Huw Davies group. “During the past five years, we’ve developed the fundamentals for C-H functionalization and documented that the concept is viable,” Davies says. “Now itself that determines the process of the In 2015, the CCHF launched online sym- we’re ideally positioned to maximize the reaction—we’ve developed advanced posia on recent advances in C-H function- further development of this chemistry and catalysts that allow us to control which alization. Graduate students and chemistry move forward to apply it.” carbon-hydrogen bond within a molecule faculty from up to forty-five countries join Traditionally, organic chemistry has will react and when.” the symposia, held about four times a year. focused on the division between reactive, C-H functionalization opens unex- “We have leading voices in the field or functional, molecular bonds and the plored chemical space by taking petro- give these free talks that are easy to join inert, or nonfunctional bonds carbon-car- leum byproducts, which have a lot of live and participate in,” Davies says. “The PHOTOGRAPHY STEPHEN NOWL AND bon (C-C) and carbon-hydrogen (C-H). carbon-hydrogen bonds, and transform- aim is to further expand the field of C-H The inert bonds provide a strong, stable ing them from waste into useful materials. functionalization by introducing it to grad- scaffold for performing chemical synthe- It also strips out steps from the linear uate students and other chemists around sis with the reactive groups. C-H func- process of traditional organic synthesis, the world.”—Carol Clark WINTER 2018 EMORY MAGAZINE 13
P O I N TS O F I N T E R E ST IF YOU LOOK AT THE SCIENCE, YOU CAN SEE THERE IS A LOT OF POTENTIAL IN PLANTS. The Power of Plants GROWING NEW CURES Cassandra Quave leads antibiotic drug discovery research focused on identification and analysis of botanical remedies used in the traditional treatment of infectious disease. C assandra Quave, an ethnobotanist With a patent on a compound she pH of the vinegar can balance the alkaline with Emory College’s Center for the teased from the roots of an elmleaf black- pH that comes from such infections, effec- Study of Human Health, elicits a berry that helps battle antibiotic-resistant tively slowing the growth of the fungus. handful of nods when she asks whether her staph, Quave is a sought-after instructor. “Homeopathy has given botanicals a students have seen or grabbed a bottle of She starts with the ancient history and bad rap, I think. But if you look at the sci- aloe juice at a high-end grocery checkout. cultural interactions of botanical medicine ence, you can see there is a lot of potential So-called green juices are restorative, before zipping through the plants that in plants. It’s good science,” says Pintas, according to ads propped up by the bottles. form the basis of drugs for everything who is further exploring her research in Good for the skin, one student murmurs. from infectious diseases to cancer and Quave’s lab as part of her honor’s thesis. But today Quave is talking to her med- the safety and ethical issues in ongoing Such knowledge is important not just ical botany class about plants used for research. for would-be physicians but also for any- gastrointestinal needs. She explains that “Once they understand the Latin one who wants to think more deeply about an Egyptian medical papyrus of herbal names of the plants and see how related their own health care. knowledge, dating to 1550 BC, first iden- species share chemistry, they can con- First-year student Kat Bagger 21C de- tified aloe vera as a treatment that still nect the dots to see how it all works,” veloped an understanding of the fine line works today: the stimulant from the family Quave says. “That’s when it is really great, between toxicity and treatment that comes of flowering plants solves constipation by because so many of them say they think with plant-based medicines. quickly speeding up the colon muscles. about the world and their health in a Digitalis, for instance, comes from the “It always makes me laugh, because whole new way.” poisonous foxglove plant, but controlled it’s basically a jug of laxative that people A course that details the plant com- use of the plant’s shouldn’t be chugging, but will, right as pounds and the underlying mechanisms cardiac glyco- they stand in line,” Quave says of the neon of action of botanical drugs is also a prime sides helps with green aloe juices. “It makes me wonder if example of the human health program, a congestive heart they make it home without stopping.” pioneering effort that highlights Emo- failure. From aspirin to the chemotherapy drug ry’s diverse efforts in health education, “I was one of Taxol, some of the world’s most common research, and the liberal arts. those people who and important medicines come from plants. Stephanie Pintas 18C, a human health thought natu- P H O T O G R A P H Y C O U R T E S Y O F M I R KO PA I A R D I N I Quave’s Botanical Medicine and Health major, says the course has reinforced her ral meant safe, course combines botany, chemistry, plans to focus on integrative medicine— but it’s so much anthropology, and pharmacology to give with its approach to preventive, holistic more complex students the practical ability to suss out care—after medical school. than that,” says P H O T O G R A P H Y K AY H I N TO N what is marketing and what is science Pintas had her own success in Bagger. “It’s so when it comes to plant-based “cures” researching apple cider vinegar as a treat- eye-opening.”— such as the aloe juice. ment for skin fungal infections. The acidic April Hunt 14 EMORY MAGAZINE WINTER 2018
SEEKING THE CELLS WHERE HIV HIDES Yerkes experts have identified new targets in HIV-infected patients already on antiviral treaments Scientists at Yerkes National Primate and bone marrow, and contain replica- HIV-positive individuals who had been Research Center have identified an addi- tion-competent and infectious virus.” on antiviral drugs for an average of three tional part of the HIV reservoir, immune Guido Silvestri, division chief of years. cells that survive and harbor the virus de- microbiology and immunology at Yerkes Based on the team’s findings, Paiar- spite long-term treatment with antiviral and a Georgia Research Eminent Schol- dini says, CTLA4 should be considered drugs. The findings are published online ar, is a coauthor of the study. The Yerkes as an additional target when designing in the journal Immunity. team worked with researchers at NCI/ immunotherapies aimed at purging the The cells display a molecule called Leidos Frederick, led by Jacob Estes, viral reservoir. CTLA4, the target of an FDA-approved using a technique called “DNAscope,” to cancer immunotherapy drug, ipilimum- visualize latently infected cells in lymph ab. This information should help those nodes. Previous research had shown trying to eradicate HIV from the body. HIV-infected cells persist in regions of Researchers led by Mirko Paiardini, the lymph nodes called B cell follicles. associate professor of pathology and The newly identified group of infected laboratory medicine at the School of cells is found outside the B cell follicles. Medicine and Yerkes and part of the Em- Working in collaboration with Rafick ory Vaccine Center, infected macaques Sekaly at Case Western Reserve Univer- with HIV’s relative SIV and treated sity, the research team also showed the them with standard antiviral drugs sim- CTLA4-positive PD1-negative cells have ilar to what humans receive for HIV. At the characteristics of regulatory T cells, the time of analysis, eight out of nine of whose job is to put a brake on the im- the animals showed undetectable SIV in mune system and prevent it from getting their blood. The team probed for CD4+ too excited. memory T cells, which are known to “It provides a strong rationale for shelter persistent virus. targeting these cells,” Paiardini says. “De- “We found that a certain group pleting latently infected T-regs can not of memory CD4+ T cells displaying only reduce the reservoir, but also induce CTLA4, but not another co-inhibitor a stronger antiviral immune response.” receptor called PD1, harbor viral DNA The researchers also worked with at higher frequencies than other groups Vincent Marconi, a physician treating of memory CD4+ T cells,” Paiardini says. HIV in Atlanta, to confirm similar cells LET’S BE SPECIFIC Mirko Paiardini has “These cells can be found in multiple were present in human lymph nodes. identified particular cells that harbor latent HIV. tissues, such as lymph node, spleen, gut, The human samples came from six The Biggest Gift Yet For decades, the Woodruff Foundation has served as the university’s advocate and partner, supporting education and mak- The Robert W. Woodruff Foundation has pledged $400 million to ing greater quality of life possible for Emory’s patients. In 1979, find new cures for disease, develop innovative patient care models, Robert W. Woodruff, the late leader of The Coca-Cola Company, and improve lives while enhancing the health of individuals in need. and his brother, George Woodruff, gave Emory the then-record P H O T O G R A P H Y C O U R T E S Y O F M I R KO PA I A R D I N I The transformational gift, the largest ever received by Emory sum of $105 million, the first nine-figure gift to an institution of University, will change the lives of patients and their families. higher education. Through a new Winship Cancer Institute Tower in Midtown and The recent gift “will allow us to accelerate the scientific dis- a new Health Sciences Research Building on Emory’s Druid Hills coveries needed for breakthroughs in patient care and to extend P H O T O G R A P H Y K AY H I N TO N campus, the gift will help advance new solutions for some of our reach in reducing the burden of disease for patients and their medicine’s most challenging diagnoses and improve the out- families,” says Jonathan Lewin, Emory executive vice president for comes for future generations. health affairs. WINTER 2018 EMORY MAGAZINE 15
P O I N TS O F I N T E R E ST In Global Health, Context Is Critical JAMES LAVERY IS THE FIRST CONRAD N. HILTON PROFESSOR IN GLOBAL HEALTH ETHICS G lobal biomedical and public health research—whether introducing genetically modified mosquitoes to fight dengue fever or testing new medicines to prevent HIV transmission from mother to child—is aimed at finding and implementing solutions to some of the world’s most pressing health problems. That’s obviously a fundamen- tally ethical pursuit. Isn’t it? Yes, says James Lavery, recently named the first Conrad N. Hilton Professor in Global Health Ethics. But failure to understand the social and political context in which the work is being done, or to know and address how stakeholders perceive a project’s implications, has the potential to sink even the most well-intentioned, well-funded, otherwise well-designed research study. Lavery, who also is a faculty member in the Emory Center for Ethics, likens what he does to be- ing an architect. He works with people who may be designing lovely and functional structures to make sure they don’t build upon unstable foundations or in unsuitable locations. Consider the mosquito net program that died because the white color of the net represented death in the country where it was being tested. Or the HIV pre-exposure study that was abruptly shut down after the sex workers involved in the study, who felt their concerns had not been taken seriously, staged a protest at an international AIDS meeting. Both projects likely looked great on the blueprint but fell apart in the construction phase. I L L U S T R AT I O N S T E P H E N N O W L A N D Global research is especially tricky, says Lavery, since the majority of programs are conducted in low- and middle-income countries by research- James Lavery ers and funding from high-income countries. 16 EMORY MAGAZINE WINTER 2018
5 NURSING SCHOOL I’M NOT TRYING IN TOP FIVE TO INTRODUCE ADDITIONAL FOR NIH OBSTACLES FOR SCIENTISTS. FUNDING The Nell Hodgson Woodruff School of Nursing is again among the top five nursing schools in the US for funding from the Na- tional Institutes of Health (NIH). In 2017, the school received $7.8 million in NIH funding as part of a total portfolio of $14.9 million. This includes twenty NIH Researchers face different cultures, different languages, an imbalance research awards, among which six were of power and knowledge, and, sometimes, lingering distrust and fear training and/or career development awards. of exploitation. The School of Nursing’s leading research Lavery works to ensure that the core commitments and ethical inten- is reflected in several current projects. This tions of global health research are translated into action and preserved trend marks a notable uptick in NIH funding through relationships with stakeholders, beginning with the scientists in less than a decade; the school was No. 38 and people who fund them, and extending throughout the communities in funding in 2009. touched by studies. He’s most interested in what he calls the human infrastructure of 3 global health ethics, and community engagement is how this infrastruc- ture comes about—how researchers identify and manage non-obvious stakeholder interests, demonstrate respect and trustworthiness, and build legitimacy by creating opportunities for dialogue and deliberation. “I’m not trying to introduce additional obstacles for scientists,” says Lavery. Instead, he consults with them—and the people who fund THREE them—to help plan, design, manage, and evaluate strategies for engaging with stakeholders in order to make their research more successful and IN GOOD ethically robust. Creating a community engagement strategy is like imagining and COMPANY creating a building, Lavery says. He sits with the scientists, discussing their vision, what they hope their “building” will accomplish and for Three Emory professors are among only whom. Who are the stakeholders? What are constraints of space, budget, seventeen researchers around the country regulations? Will it fit? Be appropriate? Accepted? to receive Distinguished Investigator grants “Our work has been to figure out analogous elements, such as terms from the Brain and Behavior Research of research partnerships, ethical commitments, and guiding principles— Foundation. The $100,000, one-year grant methods for integrating community engagement activities with program is the foundation’s largest award, designed management,” Lavery says. “We then help researchers and funders to support innovative projects that seek integrate these elements to develop blueprints and project management new potential targets for understanding strategies.” and treating a wide range of mental health Based on years of investigating such “buildings,” including many that disorders. No other university had more than never got off the ground, Lavery and his team are constructing a “Learn- two researchers earn the award. ing Platform” to facilitate the process for funders and researchers. Each Emory College psychology professor Pa- I L L U S T R AT I O N S T E P H E N N O W L A N D new building, or project, is completely different and customized. tricia Brennan, and J. Douglas Bremner and James Curran, dean of the Rollins School of Public Health, believes Andrew H. Miller, both physicians and pro- Lavery will “provide leadership in public health ethics across the university fessors in the School of Medicine, received and serve as a resource to Emory’s global ethics partners.”—Sylvia Wrobel the 2017 awards, announced in December. WINTER 2018 EMORY MAGAZINE 17
P O I N TS O F I N T E R E ST SALVAGING “Data from CIREN centers help drive rulemaking to make vehicles safer for pas- CIREN centers are awarded funding for research for either a medical center WRECK AGE sengers,” says Jonathan Rupp, associate professor of emergency medicine and arm or an engineering center arm. The Emory/Grady collaboration is one of two W principal investigator of the newly formed programs in the country that have been ith more than three hundred CIREN center at Emory and Grady. “CIREN awarded both a medical center and an thousand motor vehicle deaths relies on high-volume trauma centers like engineering center designation. in the US each year, and more Grady’s Marcus Trauma Center to conduct “This is an incredible honor that re- than one thousand in Georgia alone, most research on injuries following car crashes. flects the national prominence of Grady’s of us either have been directly affected by This CIREN award would not have been Marcus Trauma Center and the expertise a car accident or worry that we will be. of the engineering and medical teams A new research project could steer brought together for this project,” says those statistics in a better direction. David Wright, professor of emergency Emory’s Injury Prevention Research Cen- medicine at Emory and coprincipal inves- ter, along with Grady Memorial Hospital Data from CIREN tigator of the CIREN award. “Collaborators and collaborators at the University of will spend the next five years collecting Michigan, have been awarded almost $4 centers help drive and analyzing data to better understand million for a five-year project to study motor vehicle crashes in the metro- rulemaking to make the mechanisms of injuries from modern automobiles.” Atlanta area that result in injuries treated vehicles safer for Researchers expect to investigate six- at Grady. The project is funded by the ty to sixty-five metro-Atlanta automobile National Highway Traffic Safety Admin- passengers. crashes per year that result in injury. At istration (NHTSA) and will create a Crash the completion of the study, the investiga- Injury Research and Engineering Network tors hope to have data on more than three (CIREN) center for research. hundred patients injured in crashes. With a goal to improve vehicle safety “Motor vehicle accidents are the No. 1 and support injury prevention, CIREN possible without the strong, collaborative trauma we see at Grady, resulting in thou- centers collect data on the performance relationship between Emory and Grady.” sands of crash victims each year,” says of vehicles in crashes and the resulting Participants will be enrolled in the Peter Rhee, chief of acute care surgery at injuries. CIREN is one of the NHTSA’s study when brought by ambulance or Grady Health System. “We are excited to major data collection systems for motor helicopter to Grady, Georgia’s busiest continue contributing to the work in the vehicle crashes. Following an extensive Level 1 trauma center, following a crash. new CIREN center, in hopes of better un- quality-control process, CIREN case data The Emory/Grady center is one of seven derstanding how to continually improve are then made available to the public. designated CIREN centers in the US. the safety of our drivers and passengers.” P H O T O G R A P H Y B R A I N I L L U S T R AT I O N : B O N A K I M 18 EMORY MAGAZINE WINTER 2018
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