Individualisierte Nierenersatztherapie beim kritisch Kranken - Dialyseseminar Dezember 2020 Berlin
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Dialyseseminar Dezember 2020 Berlin Individualisierte Nierenersatztherapie beim kritisch Kranken 06.12.20 Dr. Mariam Abu-Tair 1
Dialyseseminar Dezember 2020 Berlin KLINISCHER FALL Übernahme eines anamnestisch 160 kg schweren 53 jährigen Patienten Terminale Niereninsuffizienz unklarer Genese; V.a. hepatorenales Syndrom Vordiagnosen: Leberzirrhose V.a. NASH; Ausschluss KHK bei leichtgradig eingeschränkter Pumpfunktion; Diabetes mellitus Typ 2 ED 1995 (HbA1c aktuell 4,7%) Auswärts tägliche UF bei nicht traktablen Ödemen, Pleuraergüssen, Aszites Direkte Verlegung auf die Intensivstation bei respiratorischer Insuffizienz und schwerer Hypotonie Versuch Volumenentzug mittels CiCaCVVHD ohne Erfolg bei steigendem Katecholaminbedarf Implantation eines gecufften Tesiokatheters in den Bauch zur Durchführung einer PD; danach kontinuierliche Negativbilanzierung möglich; nach Stabilisierung der Vitalparameter, Ausschleichen der Katecholamine und Extubation Implantation eines Tenckhoff Katheters durch die Klinik für Viszeralchirurgie Entlassung des Patienten nach 2 Monaten und 60 kg Gewichtsverlust in die Häuslichkeit mit fortgesetzter CAPD 06.12.20 Dr. Mariam Abu-Tair 3
Dialyseseminar Berlin 2020 06.12.20 Dr. Mariam Abu-Tair 4
Search results Save Review Dialyseseminar Berlin 2020 Blood Purif Received: April 28, 2020 Accepted: September 5, 2020 Published online:Review Perit Dial Int. 2020 Sep;40(5):496-498. doi: 10.1177/0896860820953050. DOI: 10.1159/000511390 October 5, 2020 Successfully treating three patients with acute kidney injury secondary to COVID-19 by peritoneal Peritoneal Dialysis Is an Option for Acute dialysis: Case report and literature review Kidney Injury Management in Patients with COVID-19 Abdullah K Al-Hwiesh 1 , Abdelgalil Moaz Mohammed 1 , Mahmoud Elnokeety 1 , 2, 3, Amani Al-Hwiesh Nadia Al-Audah Syed Esam 1 , Ibrahiem Saeed Abdul-Rahman 1 José M. Rodríguez-Chagolla a Enzo Vásquez Jiménez b Leticia Herrera Arellano a Affiliations expand Alberto Villa Torres a Nayeli Acosta García a Dolores Aleman Quimbiulco a PMID: 32998645 DOI: 10.1177/0896860820953050 Sergio Armeaga Aguilar a Magdalena Madero b aNephrology Department, Centro Médico Issemym Toluca, Toluca de Lerdo, Mexico; bNephrology Department, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, Mexico Abstract Coronavirus Disease 2019 (COVID-19) is a pandemic disease that increased the burden on heal care system. In the Kingdom of Saudi Arabia, 74,795 cases have been reported until 26 May 20 and the number of cases is rapidly increasing. The mortality rate of COVID-19 worldwide is 6.37 Keywords Here wesyn- nally shown to be caused by “severe acute respiratory report three cases of acute kidney injury (AKI) secondary to pneumonia of severe COV COVID-19 disease · Peritoneal dialysis · Acute kidney injury drome coronavirus 2” (SARS-CoV-2) [3].19; Thethey were treated with automated peritoneal dialysis (PD) with full recovery. To the best of o World Health Organization recognized this disease as a pan- few reports in the literature have discussed the use of PD in AKI secondary to COVI knowledge, demic, and by April 2020, cases have been reported in 211 19. Abstract countries, with more than 1.9 million confirmed cases In December 2019, cases of acute respiratory illness of un- [4]. In Mexico, about 256,848 cases have been diagnosedAKI; COVID-19; automated peritoneal dialysis. Keywords: known origin were reported in Wuhan, China. The disease is in all of the states [5]. Since the beginning of the epidem- caused by “severe acute respiratory syndrome coronavirus ic, kidney injury associated with COVID-19 disease has 2”. After identifying severe lung damage, injury to other or- been documented, in percentages as high as 15% [6]. gans, such as the kidney, has been identified. Peritoneal di- However, the available data suggest that Similar the preva-articles alysis is a renal replacement therapy (RRT) and is at least as lence of acute kidney injury (AKI) in patients with CO- effective as other extracorporeal therapy options, with sig- Acute peritoneal dialysis in COVID-19. VID-19 is variable. In another cohort study (n = 1,099), nificant06.12.20 cost-effective advantages. However, this strategy is Dr. Mariam 5.3% of patients required admission to theAbu-Tair Parapiboon intensive careW, Ponce D, Cullis B. 5 rarely used for the management of acute kidney injury in unit (ICU) and only 0.5% of patients had AKI [7]. Perit Dial Int. 2020 Jul;40(4):359-362. doi: 10.1177/0896860820931235. Epub 2020 Jun 19.
Dialyseseminar Berlin 2020 Perit Dial Int. 2015 Jul-Aug; 35(4): 397–405 Peritoneal dialysis modalities used in acute kidney injury. Adapted from Ponce et al. (28). IPD = intermittent peritoneal dialysis (PD); CEPD = chronic equilibrated PD; HVPD = high-volume PD; TPD = tidal PD; CFPD = continuous-flow PD. 06.12.20 Dr. Mariam Abu-Tair 6
Therapeutic Apheresis and Dialysis 2018 doi: 10.1111/1744-9987.12660 © 2018 The Authors. Therapeutic Apheresis and Dialysis published by John Wiley & Sons Australia, Ltd on behalf of International Society for Apheresis, Dialyseseminar Berlin 2020 Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy Acute Kidney Injury in Critically Ill Patients: A Prospective Randomized Study of Tidal Peritoneal Dialysis Versus Continuous Renal Replacement Therapy Abdullah Al-Hwiesh,1 Ibrahiem Abdul-Rahman,1 Fredric Finkelstein,2 Jose Divino-Filho,3 Hatem Qutub,1 Nadia Al-Audah,1 Abdalla Abdelrahman,4 Nazeeh El-Fakhrany,1 Mohammed Nasr El-Din,1 Tamer El-Salamony,1 Abdulsalam Noor,1 4 A Al-Hwiesh Mohammed Al-Shahrani 1 , andetKhalid al. Al-Otaibi1 1 Nephrology Division, King Fahd Hospital of the University, Al-Khobar, Imam Abdulrahman Bin Faisal 2 University, Saudi Arabia;2.andOutcome TABLE Yale University, of renalNewreplacement Haven, CT, USA; and 3in therapy Karolinska Institutet, CLINTEC, the two groups 4 Division of Renal Medicine, Stockholm, Sweden; and Department of Electrical Engineering, Queens University, Kingston,Group ON, Canada A Group B Outcome N = 62 N = 63 P-value Infectious complications related to dialysis, N (%) 11 (17.7) 6 (9.5) 0.0084 Time to prepare dialysis access and initiate dialysis, 0.2010 Abstract: Few studies have discussed the role of perito- (min), median (IQR) between 35 (30–37)groups in regard to patients’ 38 characteristics. (32–40) The neal function, Recovery of kidney dialysis (PD) in managing acute kidney injury (AKI) N (%) survival 22 (35.5)at 28 days was significantly38 better in the patients (60.3) 0.0056 in critically ill patients. The present study compares the treated with TPD when compared to CVVHDF (69.8% Resolution of AKI (days), outcome median of AKI (IQR) care unit (ICU) patients ran- in intensive vs.8 46.8%, (7–10)P < 0.01). Infectious complications 5 (4–6) were signifi- 0.0044 ICU stay (days),domized medianto(IQR)treatment with tidal PD (TPD) or continuous cantly less (P < 0.01) in the TPD 9 19 (13–20) (7–11) group (9.5%) when 0.0031 Need of chronic venovenous dialysis, N hemodiafiltration (%) (CVVHDF). One hundred 7 (11.3) to the CVVHDF group (17.7%). compared 6 (9.5) Recovery of 0.3112 Mortality, N (%)and twenty-five ICU patients with AKI were randomly kidney function (60.3% vs. 35.5%), median 33 (53.2) time to resolu- 19 (30.2) 0.0028 allotted to CVVHDF, (Group A, N = 62) or TPD, tion of AKI and the median duration of ICU stay of (group B, N = 63). Cause and severity of renal injury were 9 days (7–11) vs. 19 days (13–20) were all in favor of TPD AKI, acute kidney injury; ICU, intensive care unit; IQR, interquartile(P assessed at the time of initiating dialysis. The primary out- range. < 0.01). This study suggests that there are better out- come was hospital mortality at 28 days, and secondary comes with TPD compared to CRRT in the treatment of outcomes were time to recovery of renal function, dura- critically ill patients with AKI. Key Words: Acute kidney Therapeutic Apheresis and Dialysis 2018 tion of stay in the ICU, metabolic and fluid control, and injury, Acute tubular necrosis, Continuous venovenous doi: 10.1111/1744-9987.12660 and acidosis improvement were deemed to have of sensorial been achieved, and hemodynamic parameters. CVVHDF (Group hemodiafiltration, A, N =therapy, Renal replacement 62) orSepsis, TPD ©(Group B, 2018 The Authors. Therapeutic Apheresis and Dialysis pu No statistically significant differences were observed Tidal peritoneal dialysis. Japanese Society for Apheresis, and Japanese Society for Dia or when urine output had improved, or both. End- N = 63) (Fig. 2). Patient’s demographic and clinical points included cessation of dialysis after improve- characteristics are shown in Table 1. There was no 06.12.20 ment and a minimum period of 3 days of not requiring dialysis was necessary for the patients to Acute kidney injury (AKI) is a common Dr. Mariam compli- statistically significant difference in age, gender, the Abu-Tair Hyman et al.(IQR) (2) havesystolic reported aand transition of dialy- Acute Kidney Injury in median diastolic blood pressure, 7 cation in patients treated in the intensive be classified as successfully withdrawn from dialysis, care unit sis methods prescribed for AKI from 1994–1995 median (IQR) baseline eGFR and the initial median to Randomized Study o
DISCUSSION hemodialysis, CVVHD, CVVHDF or PD. Such a BUN, blood urea nitrogen; Cr, serum creatinine; CVVHDF, continuous venovenous hemodiafiltration; HCO3, serum bicarbonate; IQR, interquartile range; K,The serum potassium; TPD, tidal peritoneal dialysis;requires, decision is not always easy, taking into consider- UF, net ultrafiltration. management of AKI in ICU setting ation the hemodynamic instability of the ICU in addition to conservative treatment, a decision patients and the feasibility of implementing the dif- Dialyseseminar Berlin 2020concerning when to start RRT. Once RRT DISCUSSION is hemodialysis, CVVHD, ferent CVVHDF modalities. or PD. For the last Such a PD has two decades, needed, the treating physician should choose decision is been not always easy, taking class into treatment consider- for ICU considered a second The management of AKI between in ICU setting its different requires, modalities, i.e. intermittent ation the patients who develop hemodynamic AKI and instability it hasICU of the been rarely in addition to conservative treatment, a decision patients and the feasibility of implementing the dif-might be used in the developed world (2). This concerning when to 4. TABLE start RRT. Adverse Once events RRTto treatment according is becauseFor group modalities. ferent of lack the of lastPDtwo experience, decades,and/or PD has knowledge needed, the treating physician should choose by intensivists and nephrologists working in ICU set- CVVHDF TPD been P-valueconsidered a second class treatment for ICU between its different modalities, i.e. intermittent patients who tings, the limitations develop AKI and attributed to PD,rarely it has been and/or a lack † Hypotension 27 (43.5) 10 (15.9) 0.0016 Infections 11 (17.7) 6 (9.5) used 0.0036 in the developed world (2). This might be ‡ Catheter change TABLE 4. Adverse events according 14 (22.6) to treatment 5 (7.9) group 0.0007 because of lack of PD experience, TABLE 5. Causes ofand/or knowledge death in the two groups Bleeding events§ 17 (27.4) 4 (6.3) 0.0008 Arrhythmias ¶ CVVHDF 13 TPD(21.0) 5 (7.9) P-value by intensivists and nephrologists working 0.0023 in ICU Group A set- Group B Hypoglycemia 5 (8.1) 3 (4.8) tings, 0.0488 the limitations attributed Cause of death to PD, and/or N (%) a lack N (%) P Hypotension† Hypomagnesemia 27 (43.5) 106(15.9) (9.7) 7 (11.1) 0.0016 0.3212 Infections Hypocalcemia 11 (17.7) 6 (9.7) 6 (9.5) 6 (9.5) 0.0036 — Sepsis 13 (20.9) 8 (12.7) 0.0232 Catheter change‡ Hypophosphatemia 14 (22.6) †† 5 5(7.9) (8.1) 7 (11.1) 0.0007 0.1121 ARDS 5 (8.1) 2 (3.2) 0.0361 Bleeding events§ Thrombocytopenia 17 (27.4) 410 (16.1) (6.3) 3 (4.8) 0.0008 0.0046TABLE DIC5. Causes of death in the5two (8.1)groups1 (1.6) 0.0066 ¶ Hepatic failure 7 (11.3) 6 (9.5) 0.2344 Arrhythmias 13 (21.0) 5 (7.9) 0.0023 Group A 1Group (1.6) B † All hypotensive episodes were recorded from initiation until Acute infective endocarditis 0 (0) 0.5454 Hypoglycemia end of RRT.5 (8.1) Hypotension3 means (4.8) at least0.0488 Cause one hypotensive of deathMethanol toxicity N (%) epi- 2N (%) (3.2) P 2 (3.2) — Hypomagnesemia sode during 6 (9.7) 7 (11.1) RRT. ‡Catheter change due0.3212 to infection or mal- Total 33 (53.2) 19 (30.2) 0.0021 Hypocalcemia function. 6 (9.7) § 6 (9.5)reported when Bleeding events — Sepsis is transfusion 13 (20.9) 8 (12.7) 0.0232 Hypophosphatemiarequired. 5 (8.1) ¶ Arrhythmia 7means (11.1) supraventricular 0.1121 ARDS or ventricu- 5 (8.1) distress2 syndrome; ARDS, acute respiratory (3.2) 0.0361 DIC, disseminated †† Thrombocytopenialar. †† 10 (16.1) Thrombocytopenia3related (4.8) to the procedure. 0.0046 DIC 5 (8.1) intravascular coagulopathy. 1 (1.6) 0.0066 Hepatic failure 7 (11.3) 6 (9.5) 0.2344 † All hypotensive episodes were recorded from initiation until Acute infective endocarditis 1 (1.6) 0 (0) 0.5454 end of RRT. Hypotension means at least one hypotensive epi- © 2018 The Authors. Therapeutic Apheresis and Dialysis published by John Methanol toxicity 2 (3.2) 2 (3.2) — Wiley & Sons Australia, Ltd on behalf of International Society for Apheresis, sode during RRT. ‡Catheter change due to infection or mal- Total 33 (53.2) 19 (30.2) 0.0021 § Ther Apher Dial, Vol. ••, No. ••, 2018 Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy function. Bleeding events reported when transfusion is ¶ required. Arrhythmia means supraventricular or ventricu- ARDS, acute respiratory distress syndrome; DIC, disseminated Therapeutic Apheresis and Dialysis 2018 lar. ††Thrombocytopenia related to the procedure. intravascular coagulopathy. doi: 10.1111/1744-9987.12660 © 2018 The Authors. Therapeutic Apheresis and Dialysis publ Japanese Society for Apheresis, and Japanese Society for Dialy © 2018 The Authors. Therapeutic Apheresis and Dialysis published by John Wiley & Sons Australia, Ltd on behalf of International Society for Apheresis, Ther Apher Dial, Vol. ••, No. ••, 2018 Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy Acute Kidney Injury in Randomized Study o 06.12.20 Dr. Mariam Abu-Tair Continuous Re 8
Clinical and Experimental Nephrology https://doi.org/10.1007/s10157-018-1598-7 Dialyseseminar Berlin 2020 ORIGINAL ARTICLE Effect of peritoneal dialysis vs. haemodialysis on respiratory mechanics in acute kidney injury patients Clinical and Experimental Nephrology https://doi.org/10.1007/s10157-018-1598-7 Cibele Puato Almeida1 · André Luís Balbi1 · Daniela Ponce1 ORIGINAL ARTICLE Kein Unterschied zwischen beiden Gruppen bezügl. Ventilation, Weaning, Received: 23 January 2018 / Accepted: 1 June 2018 © Japanese Society of Nephrology 2018 Oxygenierung Abstract Effect of peritoneal dialysis vs. haemodialysis on respirator mechanics in acute kidney injury patients Background Peritoneal dialysis (PD) and hemodialysis (HD) are options for the treatment of acute kidney injury (AKI) patients. The aim of this study was to compare the effects of PD and daily HD on respiratory mechanics of AKI patients Zur Bauchlagerung undergoing bei Peritonealdialyse invasive mechanical ventilation (IMV). wenig Daten: mögliche Lösung multiple kleinvolumige 1 1 1 Zyklen unter intraabdomineller Druckmessung (18 – 20 cm H2O) Methods A prospective cohort study evaluated 154 patients, 37 on continuous Cibele PD Puato and Almeida 94 on HD. · André Luís RespiratoryBalbi · Daniela Ponce mechanics parameters such as pulmonary static compliance (Psc) and resistance of the respiratory system (Rsr) and oxygenation index (OI) were assessed for 3 days. Patients were evaluated at moments 1, 2 and 3 (pre- and Received: post-dialysis). 23 January 2018 / Accepted: 1 June 2018 Results The initial clinical parameters were similar in the two groups, except© the age Japanese that Society was higher of Nephrology 2018 in continuous PD group (70.8 ± 11.6 vs. 60 ± 15.8; p < 0.0001). In both groups, Psc increased significantly, with no difference between the two groups—pre-dialysis (continuous PD 40 ± 17.4, 42.8 ± 17.2, 48 ± 19; HD 39.1 ± 21.3, 39. 5 ± 18.9, 45.2 ± 21) and post- Abstract dialysis (continuous PD 42.8 ± 7.2, 48 ± 19, 57.1 ± 18.3; HD 42 ± 19, 45 ± 18.5, 56 ± 24.8). Rsr remained stable among Background Peritoneal dialysis (PD) and hemodialysis (HD) are options for the treatment patients on continuous PD (pre-dialysis 10.4 ± 5.1, 13.3 ± 7.7, 13.5 ± 10.3, post-dialysis 13.3 ± 7.7, 13.5 ± 10.3, 11.1 ± 5.9) 06.12.20 Dr. Mariam Abu-Tair patients. The aim of this study was to compare the effects of PD and daily HD on respirator 9 and decreased among HD patients (pre-dialysis 10.4 ± 5.1, 10.4 ± 5.1, 10.4 ± 5, 1, post-dialysis 10.5 ± 6.8, 10 ± 4.9, 8.9 ± 4.2). undergoing invasive mechanical ventilation (IMV).
Dialyseseminar Berlin 2020 European Review for Medical and Pharmacological Sciences 2018; 22: 2432-2438 Peritoneal dialysis effectively removes toxic substances and improves liver functions of liver failure patients W.-X. Zhao, X.-M. Liu, C.-M. Yu, H. Xu, J.-R. Dai, H.-Y. Chen, L. Li, F. Chen, Y.-L. Ou, Z.-K. Zhao W.-X. ZHAO, X.-M. LIU, C.-M. YU, H. XU, J.-R. DAI, H.-Y. CHEN, L. LI, F. CHEN, Y.-L. OU, Z.-K. ZHAO EurRevMedPharmacolSci 2018; 22:2432-2438 Table III. Nephrology Department, People’s Hospital of Chuxiong Yi Autonomous Prefecture, Fourth AffiliatedGroup TNF- (pg/ml) Hospital of Dali University, Chuxiong, China IL-6 (pg/ml) PCT (ng/ml) Abstract. – OBJECTIVE: Liver failure (LF) is Key Words: a clinically complex disorder that characterizes Liver failure, Peritoneal dialysis, Plasma exchange, with hepatic dysfunction. This study aimed at Toxic substances, Liver functions. observing the therapeutic effects of peritoneal dialysis on liver function in LF patients. PATIENTS AND METHODS: This study in- p < 0.01 vsIntroduction volves 62 patients diagnosed as LF hospital- conservative treatment.2005 ized from February p
Dialyseseminar Berlin 2020 PD Katheter Implantation Laparoskopisch: unter Sicht weniger Risiko einer Verletzung des Darms Katheter liegt an gewünschter Stelle Verwachsungen können ggfs. gelöst werden Perkutan: einfach und schnell, bettseitig Nutzung unmittelbar 06.12.20 Dr. Mariam Abu-Tair 11
Dialyseseminar Berlin 2020 adapted from ISPD guidelines 06.12.20 Dr. Mariam Abu-Tair 12
Dialyseseminar Berlin 2020 adapted from ISPD guidelines 06.12.20 Dr. Mariam Abu-Tair 13
Dialyseseminar Berlin 2020 adapted from ISPD guidelines 06.12.20 Dr. Mariam Abu-Tair 14
Dialyseseminar Berlin 2020 Ggfs. zu ergänzen Antibiotika Insulin adapted from ISPD guidelines 06.12.20 Dr. Mariam Abu-Tair 15
Dialyseseminar Berlin 2020 Peritoneal Dialysis International: Journal of the International 1.768 Society for Peritoneal Dialysis Journal In Peritoneal dialysis for acute kidney injury: Equations for dosing in pandemics, disasters, and beyond Chang Yin Chionh , Fredric O Finkelstein , Claudio Ronco First Published November 11, 2020 Research Article https://doi.org/10.1177/0896860820970066 Article information Abstract Background: Peritoneal dialysis (PD) is a viable option for renal replacement therapy in acute kidney injury (AKI), especially in challenging times during disasters and pandemics when resources are limited. While PD techniques are well described, there is uncertainty about how to determine the amount of PD to be prescribed toward a target dose. The aim of this study is to derive practical equations to assist with the prescription of PD for AKI. 06.12.20 Dr. Mariam Abu-Tair 16
Dialyseseminar Berlin 2020 Komplikationen bei Peritonealdialyse: • Peritonitis/ intraabdominelle Abzedierungen • Inadäquate Dialyse • Exit- oder Tunnelinfekte • Hernien und Leckagen • Malnutrition durch Eiweissverluste 06.12.20 Dr. Mariam Abu-Tair 17
Dialyseseminar Berlin 2020 Peritonealdialyse bei akutem Nierenversagen Vorteile Nachteile • techn. einfach • Bauchhöhle mit intakter • kostengünstig Membranfunktion • kein Gefäßzugang notwendig • nicht adäquat bei schwerem • keine Blutverluste Lungenödem und • biokompatibel lebensbedrohlicher • schnellere renale Erholung Hyperkaliämie • mehr kardiovask. Stabilität • UF kann nicht exakt bestimmt • nicht nur für spezielle werden Patientengruppen wie • mögliche Proteinverluste Kinder, Pat. mit • mögliche Hyperglykämie und Herzinsuffizienz, Hypernatriämie Leberzirrhose, hämorrhagischer Diathese aus Seminars in Nephrology, Vol 37, NO1, Jan 2017, pp103-112 06.12.20 Dr. Mariam Abu-Tair 18
Dialyseseminar Berlin 2020 Peritonealdialyse ist - einfach - sicher und - effizient, um metabolische Störungen, Elektrolytstörungen und Störungen des Säure Basen und Volumen Haushalts zu beseitigen In Kliniken mit PD Erfahrung sinken Mortalität und Komplikationsraten stetig. Personalressourcen und Behandlungskosten sind geringer. 06.12.20 Dr. Mariam Abu-Tair 19
Dialyseseminar Berlin 2020 PD als Alternative und sinnvolle Ergänzung auf der Intensivstation Größer angelegte Studien zur Qualitätssicherung notwendig und damit Eintrittskarte für die Nephrologie auf alle Intensivstationen Vielen Dank für Ihre Aufmerksamkeit! 06.12.20 Dr. Mariam Abu-Tair 20
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