Erio Barale-Thomas - Beltox
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Erio Barale-Thomas
Birth: 26 February 1963 Senior principal scientist, pathology
Non-Clinical Safety
Private address Janssen R&D
Blijkerijstraat 15A Turnhoutseweg 30
2390 Oostmalle 2340 Beerse
België België
+33-769 46 63 95 +32-14 60 72 77
erio.batho@icloud.com ebarale@its.jnj.com
LinkedIn ID – ORCID ID
Date of update: 09 April 2021
BIOSKETCH
Erio Barale-Thomas graduated from the Veterinary School of Lyon, France, in 1989 and holds
a national degree in toxicologic pathology. He then joined the CRO branch of CRL close to
Lyon, and later Bayer CropScience near to Nice, France. Since 2003 he works for Janssen
Pharmaceutica in Beerse, Belgium.
Throughout his career he was interested in special stains (especially immunohistochem-
istry, immunofluorescence and electron microscopy) and special techniques, and in mentor-
ing young colleagues undergoing their veterinary pathology residency.
He currently leads the digital pathology efforts in the pathology department, for both the
infrastructure/platform and the scientific applications; he also liaises with IT (for optimizing
platform design) and other scientific departments/therapeutic areas (for synergy in bringing
tools on the platform).
He is also a strong advocate of cooperation among international toxicologic pathology
societies and is very involved in the interaction with regulatory bodies. He is a former presi-
dent of the French Society of Toxicologic Pathology and an active member of the European
and North American STP.
ORCID IDENTIFIER
https://orcid.org/0000-0002-3799-5692
PROFESSIONAL EXPERIENCE
2003–present: Senior principal pathologist at Janssen R&D
Nonclinical development and safety of pharmaceutical compounds in various therapeutic
areas: CNS, infectious diseases, immunology/immunotherapeutics, cancer, metabolic dis-
eases
Role: senior toxicologic pathologist (study pathologist, peer review pathologist for internal
and subcontracted studies); pathology expert for internal development teams; expert for
digital pathology, imaging and image analysis and for computer applications
Selected achievements (apart compound development & expert teams):Erio Barale-Thomas Page 2 • Business owner of a worldwide (4 locations) global digital pathology system and promo- tion of advanced uses of digital images. Leading role in the choice (business case, user requirements) and selection (organization of a test and discussion with the suppliers) • Leading role in the choice (business case, user requirements) and selection (comparison of and discussion with the suppliers) of a histology automate stainer • Validation team of pathology LIMS Ascentos • Business owner (validation, management) of pathology LIMS PathData6 • Close interaction with histoteam for quality control, training in advanced techniques (ex- amples: 7-level brain sectioning, H&E autostainer, slide scanner) • Support of the histoteam to develop various IHC/fluo markers (among others, kidney biomarkers like α2u-globulin, KIM-1, Clusterin; brain: FJB, GFAP…; muscle spindles; testis: Sertoli cells cytoskeleton…) • Mentoring pathology residents for short (2 months) and long (6 months) traineeships who, after their residency, very often choose toxicologic pathology as a career • Ethical use of experimental animals 1998–2003: Pathologist at Bayer CropScience Role: confirmed toxicologic pathologist for preclinical development and safety of agrochem- ical compounds Achievements: image analysis applied to the detection of hepatotoxic effects (hypertrophy, proliferation, cell degeneration). Development of several immunohistochemistry methods. Management of the training and certification of technicians for necropsy. Business owner (validation, management) of pathology LIMS 1992–1998: Junior pathologist at Chrysalis Preclinical Services (now CRL Lyon) Role: junior toxicologic pathologist in a contract research organization Achievements: necropsy and pathology of toxicology studies (pharmaceutical, chemical or agrochemical compounds). Development of immunohistochemical techniques and of image analysis applied to morphometry and to quantification in pathology. Designated (site) veterinarian, participation to the Ethical Committee 1990–1991: Military period, Centre d’études du Bouchet, Vert-le-Petit, France Necropsy and pathology (histology and immunohistology). Veterinary care Involvement in the study protocols and pathology assessment, in the Ethical Committee of the site, in the implementation of Good Laboratory Practice (GLP) 1988–1990: Veterinary practice Several months of replacement, in several clinics EUROPEAN GRANTS 2021-02–2027-01: BigPicture Part of GRANT_NUMBER: H2020-JTI-IMI2-2019-18-two-stage https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/myarea/project/945358/ program/31045243/details 2018-11–2021-03: Path-Tox Part of GRANT_NUMBER: H2020-EIC-FTI-2018-2020
Erio Barale-Thomas Page 3
https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/myarea/project/820588/
program/31045243/details
EDUCATION
2002: National certification for Experimentation on Animals, National Veterinary School of
Alfort
1993-1995: National Degree in Toxicologic Pathology, National Veterinary School of Tou-
louse and Synthélabo
1992-1993: University Degree in Experimental Toxicology, Faculty of Pharmacy of Lyon
1989-1992: Participant of the French National Degree in Veterinary Pathology, National Vet-
erinary Schools
1989: Diploma of Veterinary Studies, National Veterinary School of Lyon
CONTINUING EDUCATION
Regular participation to ESTP and Cutting Edge Pathology congresses, Europe
Regular participation to SFPT scientific meetings, France
Regular participation to Digital Pathology congresses (since 4 years), London, England
Irregular participation to STP symposiums, North America
200?-??: Seminar: Olympus AnalySIS, München??, Germany
Extensive training
2000-11: Continuing Professional Development scheme of the University of Surrey, England
(Module attended: Principles of Experimental Toxicology and Risk Assessment)
1999-09: Seminar: Ecole des Mines-CMM, Fontainebleau, France
Mathematical morphology and image analysis
1996-06: Seminar: Pfizer, Amboise, France
Histological and histopathological evaluation of the testis
1994–1999: Continuing Professional Development scheme of the BSTP, England
(Modules attended: General and Cellular Pathology, Techniques in Toxicological Patholo-
gy, Cardiovascular System, Endocrine System, Digestive Tract, Reproductive System and
Mammary Gland, Liver, Lymphoid and Hematopoietic System, Carcinogenesis, Lung and
Respiratory System, Urinary System)
1993-09: Seminar of the ILSI, Hannover, Germany
Respiratory system of laboratory animals
PROFESSIONAL CERTIFICATION
2011-03-01–present: European Registered Toxicologist
AWARDS AND RECOGNITIONS
External awards and recognitions
2018-02: external award by Thomas Nolte, Florian Kobaltzky & al – Recognition of contribu-
tions by Classical Examples in Toxicologic Pathology organizers; 3rd place (after Florian
Kolbatzky and Klaus Weber)
Janssen R&D was also recognized for it sponsorship of the Classical Examples over the
last decade through the contributions of its scientistsErio Barale-Thomas Page 4 2018-02: thank you letter by Thomas Nolte, Florian Kobaltzky & al – Participation to Classi- cal Examples in Toxicologic Pathology XXV 2017-02: thank you letter by Thomas Nolte, Florian Kobaltzky & al – Participation to Classi- cal Examples in Toxicologic Pathology XXIV 2013-09: thank you letter by Wanda Haschek-Hock – Participation to the STP Recommenda- tions for pathology Peer Review Working group 2013-09: SFPT award for Best poster at ESTP Congress, Ghent Non-invasive monitoring of hepatic stellate cell activation and potential proliferation. Ashwini Ketkar-Atre, Marjolein van Heerden, Anja Kimpe, Erio Barale, Ann Van Santvoort, Uwe Himmelreich, An Vynckier 2013-06: letter by Professeur Parodi Internal Janssen awards 2020 2018-05: Encore Platinum award by Koen Demoen – Connect, shape, lead: automation of H&E histological staining (business case for HE600 stainer) 2016-06: Encore Gold award by Maarten Vergauwen – Connect, shape, deliver: continuous effort and commitment for Ascentos project 2015-09: Encore Platinum award by Sandra De Jonghe – Lead: driving PDS-project and identifying challenges 2013-11: Encore Silver award by An Vynckier – for SFPT Best poster award at ESTP 2013 2010-04: Standards of Leadership award by An Vynckier – Lead: global digital pathology project 2008-04: thank you letter by Greet Teuns – Principal Investigator working group: construc- tive and good collaboration PROFESSIONAL AFFILIATIONS 2015–present: Digital Pathology Association 2006–present: Charles Louis Davis and Samuel Wesley Thompson DVM Foundation 2004–present: European Society of Toxicologic Pathology (ESTP) 2004–present: Society of Toxicologic Pathology (STP) 1996–present: Histochemical Society 1996–present: Société Française de Pathologie Toxicologique (SFPT) 1994–2014: British Society of Toxicologic Pathologists (BSTP) 1992–2003: Association Française d’Histotechnologie PAST AND PRESENT COMMUNITY ACTIVITIES DICOM 2019–present: Member of the Annotation ad-hoc Sub-Group of Working Group 26“Whole Slide Image” ESTP 2018–present: Member of the Working Group “Young Generation” 2018–present: Councilor for international collaboration (with participation to the Global Toxicologic Pathology Presidents Group Meeting) 2007–2014: Chair, Committee for Scientific Standards, ESTP
Erio Barale-Thomas Page 5 SFPT 2018–present: Auditor of the treasurer activities 2012–2018: Representative at the Global Toxicologic Pathology Presidents Group Meeting 2012–2018: Representative at the ESTP executive council 2012–2018: President 2008–2012: Vice-president STP 2018–present: Member of the Special Interest Group “Digital Pathology and Image Analysis” Mentoring pathology residents from French and Belgian veterinary schools during traineeships (excerpt) 2018, 2019: Sophie Nélissen (entering pathology training) 2015: Lucile Sautier (passed the ECVP board exam 2018) 2014: Lucie Charpentier (now Professor, Alfort vet school) 2011, 2012 : Virginie Piccicuto (now Pathologist, CRL) 2009: Ève Laloy (now Professor, Alfort vet school) 2007: Céline Thuilliez (now Head of Pathology, Pierre Fabre) 2001: Armelle Grevot (now Pathologist, Novartis, Basel) 2000: Xavier Palazzi (now Global Head, Pathology, Pfizer) Developing digital pathology in European veterinary schools Motivator (with Thierry Marchal from Lyon Vet School) for the creation of a European VetPath Digital Slides Network: preliminary phase (gathering team of interested institutions; pre- paring a European grant) ORGANIZATION OF SCIENTIFIC MEETINGS 2019: Member of Scientific Organizing Committee for ESTP Congress, Cologne, 2019-09 2019: Member of Organizing Committee of 7th ESTP International Expert Workshop “To- wards Regulatory Acceptance of Digital Toxicologic Pathology”, Cologne, 2019-09 2018: Member of Scientific Organizing Committee for ESTP Congress, Copenhagen, 2018-09 2017: Member of Scientific and Local Organizing Committees for Cutting Edge Pathology, Lyon, 2017-08 2008: Scientific organizer (Digital pathology workflow applied to toxicologic pathology) of SFPT scientific meeting, Sophia Antipolis, 2008-03 2005: Local organizer and host of SFPT scientific meeting and annual general meeting, Beerse, 2005-03 Member of Scientific and Local Organizing Committees for several SFPT scientific meetings (2006–) INVITED LECTURES Around animal experimentation (recurring yearly lectures) 2005–present: Lectures (in French & English): continuing education program in animal ex- perimentation compliant with French, FELASA and European (Directive 2010/63) regula- tions, University of Grenoble and Polytech
Erio Barale-Thomas Page 6 Animal protection and ethics; Euthanasia; Necropsy-histology-pathology; Drug develop- ment; Big data in pathology 2002-10: Lectures (in French): continuing education program in animal experimentation compliant with French regulations, Alfort Veterinary School Animal protection and ethics, euthanasia, necropsy, pathology PUBLICATIONS (PAPERS) As major contributor 2021: Jogile Kuklyte, Jenny Fitzgerald, Sophie Nelissen, Haolin Wei, Aoife Whelan, Adam Power, Ajaz Ahmad, Martyna Miarka, Mark Gregson, Michael Maxwell, Ruka Raji, Joseph Lenihan, Eve Finn-Moloney, Mairin Rafferty, Maurice Cary, Erio Barale-Thomas, Donal O’Shea. Evaluation of the Use of Single- and Multi-Magnification Convolutional Neural Networks for the Determination and Quantitation of Lesions in Nonclinical Pathology Studies. Toxicologic Pathology. https://dx.doi.org/10.1177/0192623320986423 2021: Erio Barale-Thomas. Considerations for building a digital imaging platform for the tox- icologic pathologist: a personal perspective [Internet]. January 2021. Available from: https://osf.io/tqjyd/files/ 2021: Pierre Moulin, Katrien Grünberg, Erio Barale-Thomas, Jeroen van der Laak. IMI—Big- picture: A Central Repository for Digital Pathology. Toxicol Pathol. February 2021. https://dx.doi.org/10.1177/0192623321989644 2020: Vanessa Schumacher, Famke Aeffner, Erio Barale-Thomas, et al. The Application, Chal- lenges, and Advancement Toward Regulatory Acceptance of Digital Toxicologic Patholo- gy: Results of the 7th ESTP International Expert Workshop (September 20-21, 2019). Toxi- cologic Pathology. December 2020. https://dx.doi.org/10.1177/0192623320975841 2020: Sophie Nelissen, Joost Lensen, Erio Barale-Thomas. Unusual Incidence and Location of Renaut Bodies in Beagle Dogs in a Nonclinical Study. Toxicologic Pathology 48(3), 524-8. https://dx.doi.org/10.1177/0192623319896256 2015: Martijn P. Lolkema, Hilde H. Bohets, Hendrik-Tobias Arkenau, Ann Lampo, Erio Bar- ale, Maja J.A. de Jonge, Leni van Doorn, Peter Hellemans, Johann S. de Bono & Ferry A.L.M. Eskens. The c-Met tyrosine kinase inhibitor JNJ-38877605 causes renal toxicity through species-specific insoluble metabolite formation. Clinical Cancer Research, 21(10), 2297-304 http://dx.doi.org/10.1158/1078-0432.CCR-14-3258 2013: Erio Barale-Thomas (as president of SFPT). Letter to the Editor: Serious inadequacies regarding the pathology data presented in the paper by Seralini et al. (2012). Food and Chemical Toxicology 53, 473-474 http://dx.doi.org/10.1016/j.fct.2012.10.041 2012: Petra Vinken, Sofie Starckx, Erio Barale-Thomas, Adriana Looszova, Manisha Sonee, Nick Goeminne, Loes Versmissen, Kristel Buyens & Ann Lampo. Tissue Kim-1 and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats. Toxicologic Pathology 40(7), 1049-62 https://doi.org/10.1177/0192623312444765 2003: Philippe Kennel, Catherine Pallen, Erio Barale-Thomas, Gemma Espuña & Rémi Bars. Tamoxifen: 28-day oral toxicity study in the rat based on the Enhanced OECD Test Guide- line 407 to detect endocrine effects. Archives of Toxicology 77(9), 487-99. https://dx.doi.org/10.1007/s00204-003-0476-5 As contributor 2021: Jonathan Janssens; Bart Hermans; Marc Vandermeeren; Erio Barale-Thomas; Marianne Borgers; Roland Willems; Greet Meulders; Cindy Wintmolders; Dries Van den Bulck; Astrid Bottelbergs; Luc Ver Donck; Peter Larsen; Dieder Moechars; Wilson Edwards; Marc
Erio Barale-Thomas Page 7 Mercken. Passive immunotherapy with a novel antibody against 3pE-modified Aβ demon- strates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice. Neurobiology of Disease Corresponding Author: Dr. Bianca Van Broeck (in press) 2019: Kyung-Jin Jang, Monicah A. Otieno, Janey Ronxhi, Heng-Keang Lim, Lorna Ewart, Konstantia R. Kodella, Debora B. Petropolis, Gauri Kulkarni, Jonathan E. Rubins, David Conegliano, Janna Nawroth, Damir Simic, Wing Lam, Monica Singer, Erio Barale, Bhanu Singh, Manisha Sonee, Anthony J. Streeter, Carl Manthey, Barry Jones, Abhishek Srivasta- va, Linda C. Andersson, Dominic Williams, Hyoungshin Park, Riccardo Barrile, Josiah Sliz, Anna Herland, Suzette Haney, Katia Karalis, Donald E. Ingber, Geraldine A. Hamil- ton. Reproducing human and cross-species drug toxicities using a Liver-Chip. Science Translational Medicine 11(517), eaax5516 (1-12). https://dx.doi.org/10.1126/scitranslmed.aax5516 2010–2011: Jennifer S. McKay, Erio Barale-Thomas, Brad Bolon, Catherine George, Jerry Hardisty, Sunao Manabe, Frédéric Schorsch, Munehiro Teranishi & Klaus Weber. A com- mentary on the process of peer review and pathology data locking. → Experimental and Toxicologic Pathology,2011, 63(1-2), 197-198 https://doi.org/10.1016/j.etp.2010.07.008 → Toxicologic Pathology, 2010, 38(3): 508-510 https://doi.org/10.1177/0192623310364024 2010–2011: Brad Bolon, Erio Barale-Thomas, Alys Bradley, Robert A. Ettlin, Carla A.S. Franchi, Catherine George, Anna Maria Giusti, Robert Hall, Matthew Jacobsen, Yoichi Konishi, David Ledieu, Daniel Morton, Jae-Hak Park, Cheryl L. Scudamore, Hiroyuki Tsu- da, S.K. Vijayasarathi & Marcel V.W. Wijnands. International recommendations for train- ing future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies. → Experimental and Toxicologic Pathology, 2011, 63(1-2), 187-195 https://doi.org/10.1016/j.etp.2010.07.006 → Journal of Toxicologic Pathology, 2010, 23(3), 171-181 https://doi.org/10.1293/tox.23.171 → Toxicologic Pathology, 2010, 38(6), 984-992 https://doi.org/10.1177/0192623310378137 2010: Daniel Morton, Rani S. Sellers, Erio Barale-Thomas, Brad Bolon, Catherine George, Jerry F. Hardisty, Armando Irizarry, Jennifer S. McKay, Marielle Odin & Munehiro Teran- ishi. Recommendations for Pathology Peer Review. Toxicologic Pathology, 38(7), 1118-1127 https://doi.org/10.1177/0192623310383991 2008: Ken A. Schafer, Rani Sellers & Erio Barale-Thomas. Letter to the Editor: Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: ap- proaches to dose selection (author reply 897-8). → Critical Reviews in Toxicology, 38(10), 895-6 http://dx.doi.org/10.1080/10408440802116504 → Toxicologic pathology 36(7), 1018-9 http://dx.doi.org/10.1177/0192623308327335 1997: Roger Burnett, Yves Guichard & Erio Barale. Immunohistochemistry for light mi- croscopy in safety evaluation of therapeutic agents: an overview. Toxicology 119(1), 83-93 https://doi.org/10.1016/S0300-483X(96)03600-1
Erio Barale-Thomas Page 8 DISSERTATIONS 1998: Human tissue bank: setting and application to the investigation of the cross reactivity of an anti-CD11a antibody (in French: Mise en place d’une banque de tissus humains : application à l’étude de la réactivité croisée d’un anticorps anti-CD11a). National Degree in Toxicological Pathology, Toulouse 1993: Pathology and target organs in toxicology (in French: Anatomopathologie et organes cibles en toxicologie). University Degree in Experimental Toxicology, Lyon PRESENTATIONS, COMMUNICATIONS Around pathology peer review 2015-06: Symposium SOFAQ, Paris: oral communication Peer Review of Histopathology data: Review of the OECD Guidance and Application. Annette Romeike & Erio Barale-Thomas 2014-06: STP Career Development Session – STP Symposium, Washington Communication with Regulators: OECD Draft peer Review Guideline as A Case Example. Annette Romeike & Erio Barale-Thomas: oral communication 2010–2014-12: Participant to the Working Group of Tox Path Societies who commented the OECD Principles of GLP 16 Advisory Document of the Working Group on Good Labora- tory Practice – Guidance on the GLP Requirements for Peer Review of Histopathology 2010-11-30: Meeting (face to face) about concepts of pathology peer review for the toxicol- ogist pathologist, with AFSSAPS-France (Dominique Abdon); organized by Erio Barale- Thomas 2010-10-26: Information session (TC) about OECD guidance on pathology peer review with professional societies (BSTP – SFPT – STP) and regulators AFSSAPS-France (Dominique Abdon) – EPA (Liem Francisca) – FDA (CT Viswanathan) – MHRA-UK (Andrew Gray); or- ganized by Erio Barale-Thomas 2010-06: STP symposium, Chicago: oral communication Peer review paper: thoughts from Europe; ESTP Executive Committee represented by Erio Barale-Thomas for the Town Hall meeting held on 21 June 2010 2009-09: Meeting of the European Society of Toxicologic Pathology, The Hague, The Nether- lands: poster Results of the “Peer review survey”: the report is open for comments. Erio Barale-Thomas & Alys Bradley Panel member 2019-04: World Toxicologic Pathology, São Paulo, Brazil Discussion on training on toxicologic pathology 2017-12: Digital Pathology Congress, London, UK Digital Pathology for Pharmaceutical Research. Will Howat (Chair), Erio Barale-Thomas, Richard Haworth & Ingrid Sjögren Session chair during a congress 2019-09: Digital Pathology Congress, London, UK Computational pathology & AI. Chair: Erio Barale-Thomas 2019-09: ESTP congress, Cologne, Germany Regulatory session. Co-chairs & session organizers: Erio Barale-Thomas, Jonathan Carter
Erio Barale-Thomas Page 9 Scientific presentation 2019-12: Digital Pathology & AI Congress, London, UK Digitalization of Toxicologic Pathology: Some Reflections on Validation and Regulatory Acceptance. Erio Barale-Thomas 2019-09: Digitalization meets pathology, ESTP congress, Cologne, Germany “Dry lab” – the digital pathology platform. Erio Barale-Thomas 2018-06: SIG Digital pathology and Image analysis at STP Symposium, Indianapolis, USA Considerations on the Use of Artificial Intelligence to Augment Toxicological Pathology: Deciphex, transforming pathology workflows. Donal O'Shea, Erio Barale-Thomas 2018-06: Mystery cases session at STP Symposium, Indianapolis, USA It's crystal clear. Erio Barale-Thomas 2018-04: World Toxicologic Pathology Congress, São Paulo, Brazil Neurotoxicity of dizocilpine with a focus on neuroanatomy. Erio Barale-Thomas 2018-02: Classic Examples in Toxicologic Pathology XXV, University of Veterinary Medicine, Hannover, Germany Routine, special and innovative techniques in neuropathology. Erio Barale-Thomas 2017-02: Classic Examples in Toxicologic Pathology XXIV, University of Veterinary Medicine, Hannover, Germany Neurotoxicity of dizocilpine (MK-801). Erio Barale-Thomas & David Abbott 2015-12: Digital Pathology Congress, London, UK Peer review with digital slides in toxicologic pathology. Erio Barale-Thomas 2015-02: Classic Examples in Toxicologic Pathology XXII, University of Veterinary Medicine, Hannover, Germany Pathology related to BACE1 or BACE2 inhibition in preclinical studies. Erio Barale (author) & Marjolein Van Heerden (presenter) 2014-10: BWGAP/Belgian Week of Pathology, Ghent, Belgium Digital pathology empowering the pathologist. Erio Barale-Thomas 2014-08: Cutting Edge Pathology / ESTP Congress, Berlin, Germany Leica Biosystems: Peer Review through digital pathology: the future is now? Erio Barale- Thomas 2013-05: DESV-APV, journée de formation SFPT, Riom, France Review on Séralini et al. Food and Chem. Toxicol. (2012). Flavia Pasello Dos Santos & Erio Barale-Thomas 2012-06: Definiens symposium, Munich, Germany 3D Ovary Reconstruction: A Test-Case Scenario for Computer Aided Histopathology. Erio Barale-Thomas 2012-04: BWGAP/Belgian Week of Pathology, Ghent, Belgium Digital pathology in preclinical sciences. Erio Barale-Thomas 1996-12: Pharmakon Research International symposium, Lyon, France Automated sperm analysis in laboratory animals with histological correlates. Roger Bur- nett, Erio Barale, Geneviève Brain & Françoise Roche 1996-04: meeting of the SFPT, Lyon, France Image analysis of atheroma plaques in a model of transgenic mouse developing ath- erosclerosis (in French). Erio Barale 1994-09: meeting of the SFPT, Paris, France Immunohistological staining and image analysis of Langerhans’ cells during type IV hy- persensitivity (in French). Erio Barale
Erio Barale-Thomas Page 10 Oral communication 2016-09: ESVP-ECVP congress, Bologna & ESTP congress, Barcelona, Spain Presentation of the 3rd joint European Congress of the ESTP, ESVP and ECVP, August 2017, Lyon, France. Pierluigi Fant, Erio Barale, Catherine Botteron & Franck Chanut 2016-09: ESTP congress, Barcelona, Spain Results of a digital pathology survey and needs of the pathology community in term of digital pathology. Jan Klapwijck & Erio Barale-Thomas 2016-09: ESTP congress, Barcelona, Spain Results of a demographic and salary survey and anticipation of needs in pathologists in the next decade. Lars Mecklenburg, Erio Barale-Thomas & John Fry 2016-04: Barco Workshop, Kortrijk, Belgium Image quality in digital pathology from slide acquisition to visualization. Erio Barale- Thomas 2011-10: Barco Workshop, Kortrijk, Belgium Digital pathology: Personal views and future of the field from a demanding user. Erio Bar- ale-Thomas 2010-06: Hamamatsu-Nanozoomer Workshop, Paris, France Pourquoi & comment Johnson & Johnson PRD est venu à l’anatomo-pathologie numérique (French). Erio Barale-Thomas Poster 2019-09: ESTP congress, Cologne, Germany Towards Predicting Drug-Induced Liver Injury with a Machine-Learning Model – Review of the TG-GATEs Database and Translation to INHAND Nomenclature. Sophie Nelissen, Ronnie Chamanza, Dozie Amuzie, Natalie Mesens (Erio Barale-Thomas: scientific advice) 2019-09: ESTP congress, Cologne, Germany Development and Validation of an Optimal Digital Pathology Workflow for Toxicologic Pathology. Mark Gregson, Erio Barale-Thomas, Matt Jacobsen, Alys Bradley, Sophie Nelis- sen, Maurice Cary, Martyna Miarka, Colin Doolan & Donal O’Shea 2019-09: ESTP congress, Cologne, Germany Development and validation of ai-based abnormality detection in rat studies. Mark Greg- son, Erio Barale-Thomas, Jogile Kuklyte, Stephanie White, Martyna Miarka, Sophie Nelis- sen, Maurice Cary & Donal O’Shea 2018-09: ESTP congress, Copenhagen, Denmark Automated artificial intelligence (AI) whole slide image analysis of Wistar rat livers as a support tool for toxicology pathologists. Martyna Miarka, Mark Gregson, Máirin Rafferty, Donal O’Shea, Erio Barale-Thomas 2014-08: Cutting Edge Pathology, Berlin, Germany Implementation of the INHAND nomenclature: the Janssen R&D experience. Virginie Piccicuto & Erio Barale-Thomas 2013-09: ESTP Congress, Ghent, Belgium Non-invasive monitoring of hepatic stellate cell activation and potential proliferation. Ashwini Ketkar-Atre, Marjolein van Heerden, Anja Kimpe, Erio Barale, Ann Van Santvoort, Uwe Himmelreich & An Vynckier. Received the best SFPT award 2013-08: Pathology Visions conference, San Antonio, USA A Novel Automated Histopathological Method for Kidney Compartmentalisation: A Toxi- cological Pathology Perspective. Ryan A Hutchinson, Erio Barale-Thomas, An Vynckier & Peter W Hamilton 2008-06: Meeting of the Society of Toxicologic Pathologists, San Francisco, USA KIM-1: Mechanistic Marker of Acute Nephrotoxicity in Male Rats following 2-Week d-
Erio Barale-Thomas Page 11 Limonene Administration. Eric McDuffie, Panneerselvam K, Manisha Sonee, Ma J-Y, Gao J, Bittner A, Erio Barale-Thomas & Sandra Snook 2008-06: Meeting of the Society of Toxicologic Pathologists, San Francisco, USA Renal Alpha 2u-Globulin Expression in Male Sprague-Dawley Rats. Eric McDuffie, Pan- neerselvam K, Wu J, Bittner A, Gao J, Morton M, Erio Barale-Thomas & Sandra Snook 2006-06: STP symposium, Vancouver, Canada IHC detection of α2u-globulin in hyaline droplets from male rat kidneys. Erio Barale- Thomas, Sandra Snook, An Vynckier, Lieve Lammens & Wendy Roosen 2002-03: Society of Toxicology meeting, Nashville, USA Detection of endocrine effects: an enhanced OECD test guideline 407. Study with Tamox- ifen. F. Chuzel, G. Espuna, Erio Barale-Thomas, C. Pallen & Rémi Bars 1998-04: British Toxicological Society meeting, Guilford, UK Initial histopathological investigation into the accumulation of pulmonary intravascular macrophages (PIMs) following bile duct ligation in the rat. Yves Guichard, Erio Barale- Thomas, Roger Burnett, E. Miot-Noirault & A. Le Pape 1997-06: BSTP meeting, Warwick, UK Observation of some unusual pathological features of the Cotton Rat. R. Burnett, E. Bar- ale, L.J. Ackerman & C.B. Spainhour 1996-09: Eurotox 96, Alicante, Spain A transgenic mouse model for atherosclerosis with appropriate cholesterol profiles and histopathology. Roger Burnett, Erio Barale, V. Ciofalo, J. Chapdelaine, U. Saini, M. Swan- son & D. Grass Case presentation 2018-04: Belgian Working Group in Anatomic Pathology meeting, Ghent, Belgium Gavage/formulation-related reflux in a tolerability study in the rat with compound X. Erio Barale-Thomas 2007-04: Belgian Working Group in Anatomic Pathology meeting, Uccle, Belgium On two cases of nephroblastoma in the laboratory rat 1997-07: Continuing professional development module, British Society of Toxicological Pathologists, Cambridge, UK On a case of colitis cystica profunda associated to a rectal prolapsus in the mouse. Erio Barale 1997-04: Continuing professional development module, British Society of Toxicological Pathologists, Edinburgh, UK On a case of pituitary adenocarcinoma with pulmonary metastases immunostained with an anti-PRL antibody in a female rat. Erio Barale Training presentation 2016-05: Formation DESV-APV, session Anatomo-pathologie et évaluation préclinique des produits de santé et des produits chimiques, Musée des Impressionnismes, Giverny, France Recherche pharmaceutique : rôle de l’anatomo-pathologiste – Recherche pharmaceu- tique : le développement du médicament. Erio Barale-Thomas 2011-05: Formation DESV-APV, session Anatomo-pathologie et évaluation préclinique des produits de santé et des produits chimiques, IPSEN, Paris, France Recherche pharmaceutique : le développement du médicament. Erio Barale-Thomas 2008-02, 2008-03: Visit of general practitioners, Janssen R&D, Beerse, Belgium Topic: Presentation of preclinical studies in the context of drug development
Erio Barale-Thomas Page 12 INTERACTION WITH SUPPLIERS 2011-10: participant, Barco Brain Storming, Kortrijk, Belgium (oral presentation, discussion) 2010-06: participant, Hamamatsu symposium, Paris, France (oral presentation, discussion) 2001-06: moderator, Xybion User Group, Special interest group in pathology, Chicago, USA LANGUAGES French (mother tongue); English (good); Italian, Dutch (basic knowledge)
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