BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection

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BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
WINTER 2012 • VOLUME 19 NUMBER 1

                                           THE OFFICIAL PUBLICATION OF
                                   THE ONTARIO COLLEGE OF PHARMACISTS

                                        BUPRENORPHINE
WORKING TOGETHER:                           GUIDELINES
PHARMACISTS AND
TECHNICIANS TEAMING
                                         THANK YOU TO
UP IN ONTARIO
                                       PRECEPTORS AND
COMMUNITIES
                                           EVALUATORS
BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
Council Members
                                             Council Members for Districts are listed below
                                             according to District number. PM indicates a public
                                             member appointed by the Lieutenant-Governor-
                                             in-Council. U of T indicates the Dean of the Leslie
                                             Dan Faculty of Pharmacy, University of Toronto.
                                             U of W indicates the Hallman Director, School of
                                             Pharmacy, University of Waterloo.

                                             H Doris Nessim              PM Margaret Irwin
                                             H Christine Donaldson       PM Javaid Khan
                                             K Mark Scanlon              PM Lewis Lederman
                                             K Esmail Merani             PM Aladdin Mohaghegh
                                             L Tracy Wiersema            PM Gitu Parikh
                                             L Farid Wassef              PM Lynn Peterson
MISSION STATEMENT
                                             L Saheed Rashid             PM Shahid Rashdi

The mission of the Ontario
                                             M Sherif Guorgui            PM Joy Sommerfreund
                                               (President)               U of T Henry Mann
                                             M Tracey Phillips           U of W David Edwards

College of Pharmacists is                    M Don Organ
                                             N Bonnie Hauser             Statutory Committees
                                             N Peter Gdyczynski          • Executive

to regulate the practice                     N Christopher Leung
                                               (Vice President)
                                                                         • Accreditation
                                                                         • Discipline

of pharmacy, through the
                                             P Rachelle Rocha            • Fitness to Practice
                                             P Jon MacDonald             • Inquiries Complaints &
                                             T Amber Walker                 Reports

participation of the public and              TH Tracy Wills              • Patient Relations
                                                                         • Quality Assurance
                                             PM   Thomas Baulke          • Registration

the profession, in accordance                PM
                                             PM
                                                  William Cornet
                                                  Corazon dela Cruz      Standing Committees

with standards of practice
                                             PM   Babek Ebrahimzadeh     • Communications
                                             PM   Jim Fyfe               • Finance
                                             PM   David Hoff             • Professional Practice

which ensure that our
                                             College Staff
members provide the public                   Office of the Registrar
                                             x 2243, urajdev@ocpinfo.com

with quality pharmaceutical                  Office of the Deputy Registrar,
                                             Director of Professional Development ,
service and care.                            Pharmacy Connection Editor
                                             x 2241, ltodd@ocpinfo.com

                                             Office of the Director of Professional Practice
                                             x 2241, ltodd@ocpinfo.com

                                             Office of the Director of Finance and Administration
                                             x 2241, ltodd@ocpinfo.com

                                             Registration Programs
                                             x 2250, jsantiago@ocpinfo.com

                                             Structured Practical Training Programs
                                             x 2297, vclayton-jones@ocpinfo.com

                                             Investigations and Resolutions
                                             x 2274, membry@ocpinfo.com

                                             Continuing Education Programs and
                                             Continuing Competency Programs
                                             x 2273, lsheppard@ocpinfo.com

                                             Pharmacy Openings/Closings, Pharmacy Sales/
Ontario College of Pharmacists               Relocation, ocpclientservices@ocpinfo.com
483 Huron Street                             Registration and Membership Information
Toronto, Ontario M5R 2R4                     ocpclientservices@ocpinfo.com

                                             Pharmacy Technician Programs
T 416-962-4861                               ocpclientservices@ocpinfo.com
F 416-847-8200                               Publications x 2229, dcross@ocpinfo.com
www.ocpinfo.com
PAGE 2 ~ WINTER 2012 ~ PHARMACY CONNECTION
BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
The objectives of Pharmacy Connection are
to communicate information about College
activities and policies as well as provincial and
federal initiatives affecting the profession; to
encourage dialogue and discuss issues of interest to
pharmacists, pharmacy technicians and applicants;
to promote interprofessional collaboration of
members with other allied health care professionals;
and to communicate our role to members and
stakeholders as regulator of the profession in the
public interest.

We publish four times a year, in the Fall, Winter,        On the Cover:
Spring and Summer.                                        Phillip Chiu and Stacy O’Neill from Keswick, ON
                                                          are just one of the many teams of pharmacists
We also invite you to share your comments,                and technicians teaming up to deliver patient
suggestions or criticisms by letter to the Editor.        care in Ontario communities.
Letters considered for reprinting must include the        Story on page 8.
author’s name, address and telephone number.
The opinions expressed in this publication do not
necessarily represent the views or official position of
the Ontario College of Pharmacists.

                                                                                WINTER 2012 • VOLUME 19 NUMBER 1

Sherif Guorgui, B.Sc.Phm., R.Ph.
President                                                                       CONTENTS
Marshall Moleschi, R.Ph., B.Sc. (Pharm), MHA
Registrar
                                                                                Editor’s Message                                               4
Della Croteau, R.Ph., B.S.P., M.C.Ed.
Editor, Deputy Registrar,                                                       Registrar’s Message                                            5
Director of Professional Development
dcroteau@ocpinfo.com                                                            Council Report                                                 6
Anjali Baichwal
                                                                                Pharmacists and Technicians Working Together                   8
Associate Editor
abaichwal@ocpinfo.com
                                                                                Integrating Technicians into the Workplace                   16
Agostino Porcellini
Production & Design / Webmaster                                                 Coroner's Geriatric & Long-Term Care Review                  18
aporcellini@ocpinfo.com
                                                                                Buprenorphine for Treatment of Opioid Dependence             21

                                                                                Privacy Enhances Patient Consultation                        30

                                                                                Accessible Customer Service Regulation                       33

                                                                                Member Survey results                                        34

                                                                                Discipline Decisions                                         36
ISSN 1198-354X                                                                  Focus on Error Prevention: Computer Alerts                   39
© 2012 Ontario College of Pharmacists
Canada Post Agreement #40069798                                                 Thank You Preceptors!                                        40
Undelivered copies should be returned to the
Ontario College of Pharmacists. Not to be                                       Evidence-based Information for Practitioners                 50
reproduced in whole or in part without the
permission of the Editor.                                                       Annual CE Coordinators Meeting                               53

                                                                                CE Resources                                                 54

                                                                                                       PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 3
BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
EDITOR'S MESSAGE

                                               If you are integrating
                                               technicians into your
                                               team, I’d like to hear what
                                               you have learned that
                                               could be shared with
                                               others.

Della Croteau, R.Ph., B.S.P., M.C.Ed.
Deputy Registrar/Director of
Professional Development

Last fall, OCP conducted a survey        you are looking for information on        our website and allows us to provide
over a period of three weeks to          practice-related issues. Columns          more timely information than what
help us improve our communica-           like “Focus on Error Prevention”          we publish in Pharmacy Connection.
tions with members, We were              and Q&As on practice are well-read
particularly interested in hearing       and valued. But you want even             Our regular e-blasts to members
your feedback on Pharmacy                more articles on practice and we will     received favourable comments.
Connection, both print and online.       work on delivering that to you. This      Members told us that these blasts
I want to take this time to thank all    issue’s cover story on technicians        provide valuable information on a
of the members who participated          being integrated into the workplace       timely basis.
in the survey. We had an excellent       is a good start. It contains real life
response, with some 30% of               examples of best practices for            Going back to the print vs
members providing their input. This      working together, profiling three         electronic format of Pharmacy
is considered to be great success in     practice settings, and addressing         Connection, we heard from many
terms of surveys so we thank you.        some of the major questions that          members on their preference.
                                         are occurring with this new model.        There is still a large number of
So what did we learn from all of                                                   you who prefer print, but there
this? We provide you a summary           If you are integrating technicians        are certainly significant numbers
on page 34 of some of our key            into your team, I’d like to hear what     who would now, or at some time
findings. Among them is the fact         you have learned that could be            in the near future, be satisfied
that you are in communication with       shared with others.                       with an online-only version of the
us. The response rate itself tells us                                              publication. As more and more of
you want to provide input, and assist    As well, our colleagues with exper-       you incorporate mobile devices
us in providing communications           tise in buprenorphine have provided       into your lives, you’ve expressed an
that you find valuable. So we will       an extensive update on its use and        interest in receiving information in
continue to ask for your input on a      place in practice, in relation to the     that format. We will work to deliver
regular basis to make sure that our      recently released clinical guidelines..   on these needs as we plan future
communications are reaching you in                                                 communications.
an effective manner.                     You also conveyed a need for more
                                         resources focusing on continuing
You also told us that Pharmacy           education. I want to remind you to go
Connection is an important vehicle       to our website where we continually
for information and that many            provide up to date information on
of you are enjoying the online           CE opportunities for all members. It
version. Responses revealed that         is one of the most popular areas of

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BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
REGISTRAR'S MESSAGE

                                                  The College continues to
                                                  meet with public health
                                                  and other stakeholders
                                                  to discuss how to best
                                                  collaborate and enhance
                                                  the current system.

Marshall Moleschi,
R.Ph., B.Sc. (Pharm), MHA
Registrar

As you’ll read in our Council Report,   fall. As you know, I spent much of        support and enable members to
last December, Council approved a       my first few months as Registrar, on      use their professional skills, knowl-
change to the previously submit-        the road, travelling to communities       edge and judgment in an integrated,
ted Bill 179 regulation, and as         across the province, delivering           evidence-based, patient-centered,
a result, the updated regulation        important messages about moving           outcome-focused health care
was re-circulated, along with an        our profession forward. The               system. Doing so will do wonders
expanded list of substances to          discussions we’ve had in large and        to improve the health of our
be administered by injection and        small group settings, the comments        population. Taking a more patient-
inhalation for routine purposes,        I’ve received – they are all very         focused approach, and building
including immunizations. Council        helpful to me and the team here at        our confidence as practitioners is a
made this change because it             OCP as we set forward to continue         mission all of us must undertake.
considered that it was in the public    our work regulating the profession
interest to permit pharmacists to       in the public interest. An important      If I didn’t get a chance to meet
exercise a broader scope in the         part of that is our new strategic         you last fall, I hope to do so at the
administration of drugs by injection    planning process which will begin in      earliest opportunity. As always, if
and inhalation.                         March and set the course for the          you have any thoughts or ideas you
                                        College over the next three years.        would like to share, I encourage you
By the time you read this, the                                                    to contact me so we can continue
consultation period will be             If you weren’t able to come out to        our dialogue on the important
complete. I hope that you had a         one of the district meetings, I hope      issues facing us this year.
chance to add your thoughts to          you were able to take a look at our
this important development. The         website where we’ve made the
College continues to meet with          presentation available to review at
public health and other stakehold-      you leisure.
ers to discuss how pharmacists
and pharmacy technicians can            “Navigating the Grey” continues to
best collaborate and enhance the        be a theme I’m incorporating into
current system. Thanks to all of you    all my work here as Registrar. To
who participated in this process.       every meeting, whether it be with
Providing your input is an important    council, our provincial and national
responsibility.                         counterparts, associations and
                                        government, I have been trying to
I want to thank those of you too        drive home the same message: that
who came out to meet with me last       the time is now for the college to

                                                                               PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 5
BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
COUNCIL report

DECEMBER 2011
Council Meeting

Proposed Amendments to the               Strategic Plan Update                    Council approves revocation
General Operating By-law #2                                                       of sections 41 and 42 of
Ratified                                 Progress continues towards               Ontario Regulation 58/11 to
                                         meeting the goals and objectives         the DPRA
As reported previously, amend-           set out in the Strategic Plan and
ments to the by-laws respecting a        Council received the progress            Council approved a motion to
revised fee structure for pharmacy       report of action taken by all            revoke sections 41 and 42 of the
related transactions were circulated     College areas since the September        Ontario Regulation 58/11 to the
to the membership for comment.           2011 Council Meeting. Activities         Drug and Pharmacies Regulation
These amendments were ratified           set in March 2009 are expected           Act (DPRA), at the time that the
by Council in December and will          to reach completion in 2012              Bill 179 Regulations under the
enable the College to better align       when Council will embark upon a          Pharmacy Act are proclaimed.
the fees with the activities associ-     new Strategic Plan. To this end, the
ated with the processing of a new        College has engaged the services         Refill authority is currently only
certificate of Accreditation. For the    of Dr. Wayne Taylor who will first       permitted in community pharma-
updated by-laws, please refer to the     conduct a governance review with         cies under the authority of the
College’s website www.ocpinfo.com        Council, and Ms. Anne Grant who          DPRA and the new provisions,
                                         will facilitate the strategic planning   upon proclamation, will broaden
                                         exercise.                                this scope to all members. This
Proposed amendment to Bill
                                                                                  motion is a simple housekeeping
179 Regulation – Approved
                                         Council also heard a presenta-           measure which Ministry officials
for Circulation
                                         tion from eHealth Ontario                requested the College approve.
                                         regarding their progress with the        It was acknowledged that upon
Council approved a change to the         development of the Medication            proclamation of these regulations,
previously submitted Bill 179 regu-      Management System, which they            comprehensive communication will
lation, and as a result, the updated     anticipate will be in place by 2013.     be forwarded to the membership to
regulation is being re-circulated,       Also noted for information was           help clarify the expectations.
along with an expanded list of           the recent release of a report
substances to be administered by         by Don Drummond on Canada’s
                                                                                  Model Standards of Practice
injection and inhalation for routine     healthcare system. These, together
                                                                                  for Canadian Pharmacy
purposes, including immunizations.       with other backgrounders, will
                                                                                  Technicians Adopted
In discussing this matter, Council       be used by Council during the
considered that it was in the public     strategic planning session to
interest to permit pharmacists to        develop a Vision Statement, define       College Council approved the
exercise a broader scope in the          values and develop broad strategic       adoption of the Model Standards of
administration of drugs by injection     priorities for this College for the      Practice for Pharmacy Technicians
and inhalation.                          next three years.                        as developed through NAPRA (the
                                                                                  National Association of Pharmacy
Updated copies of the proposed                                                    Regulatory Authorities). The format
regulation, the list of routine                                                   adopted for these standards was
injections and immunizations and                                                  drawn from that of the model
drugs for inhalation are available on                                             standards developed for Canadian
the OCP website.                                                                  pharmacists but adjusted to reflect

PAGE 6 ~ WINTER 2012 ~ PHARMACY CONNECTION
BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
COUNCIL report

the technician’s competencies. The      Government Relations                    align well with the College’s current
standards are available on the OCP                                              philosophy. Registrar Moleschi has
website.                                Effective November 1st, 2011, and       already met with several individuals
                                        following an evaluation of proposals    within the government, both at the
                                        from other GR advisors, the firm        bureaucratic and political levels, and
Registration Regulation
                                        of Leffler Consulting was selected      it is anticipated that these efforts
Resolutions approved
                                        to support the College in our           will continue so as to enable the
                                        government relations endeavors.         College to influence the develop-
Under the Registration Regulation,      Ms. Sandra Leffler has previously       ment of any new programs at an
there are references to require-        provided GR support to the College      early stage.
ments which are to be approved by       and her experience and background
Council. These requirements are
approved through resolutions and
allow the College to make changes
in these specific areas to keep the
regulation current, without having
to actually change the regulation.
The requirements in the regulation
will continue to be monitored by             Member Annual Renewal
the Registration Committee and
further recommendations for                   IS due March 10, 2012
change will be brought to Council
for approval as necessary. For a
complete chart of the requirements             The College’s online Member Annual Renewal is now available.
approved by Council and their                  NOTE: no form will be mailed to you, however email
reference in the regulations, please                  reminders will be sent.
refer to the College’s website at
www.ocpinfo.com                                Before you begin your online renewal you will need:
                                               • Credit Card or Interac (Debit Card) if paying online
                                               • User ID - This is your OCP number
New Council Members
                                               • Password - If you have forgotten your password,
Welcomed
                                                  click 'Forgot your Password or User ID?' and a new
                                                  password will be emailed to you.
Council welcomed Ms. Christine
Donaldson, who won the                         Once you’re ready:
by-election in District H (hospital            • Go to www.ocpinfo.com and click on 'Member Login'.
district) to the table. Also welcomed          • Enter your User ID (your OCP number) and your password.
was returning public appointee,                • Once you have successfully logged in, click on 'Member
Mr. Babek Ebrahimzadeh, who was                   Renewal' on the left hand side of the screen.
reappointed to serve on College
Council for a further three-year
term.

                                                                            PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 7
BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
WORKING
TOGETHER

8      Santosh Manjunath, R.Ph., and
       Andrea Ball, R.Ph.T of Zehrs
       Pharmacy in Brantford, Ontario
BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
Pharmacists and          It has been more than a year since phar-
                         macy technicians have become recognized
Technicians are          as regulated health professionals in Ontario.
teaming up in Ontario    To date, the College has registered more
                         than 500 individuals as technicians, and
communities to deliver   there are up to 5,000 individuals who are
patient care             on the road to regulation. Technicians
                         play a vital role in the pharmacy setting,
                         supporting the pharmacist in providing
                         more comprehensive patient care services.
                         By taking responsibility for the technical
                         components of dispensing within the
                         pharmacy, technicians allow pharmacists to
                         expand their services and scope of practice
                         to improve patient care.

                         With changes to pharmacists’ scope of
                         practice on the horizon, the role of the
                         technician in the pharmacy setting is
                         becoming more vital. And while there still
                         may be some barriers to full and effective
                         integration of technicians in the pharmacy,
                         there are some great examples where this
                         new model of professional collaboration
                         is working well – where technicians can
                         practice within their scope allowing the
                         pharmacist to take on more duties related
                         to direct patient care.

                         In this article, we showcase three of these
                         practice settings. Each of these pharmacies
                         took part in a pilot program organized by
                         their parent company, Loblaw. The aim of
                         the pilot was to fully integrate the registered
                         technician in the pharmacy, measuring
                         success as when the following takes place:

                         •   he registered technician spends most
                            T
                            of the day performing their duties, which
                            include accepting responsibility and
                            accountability for the technical aspects of
                            both new and refill prescriptions;
                         • The pharmacist spends most of the

                             PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 9
BUPRENORPHINE GUIDELINES - WORKING TOGETHER: PHARMACISTS AND TECHNICIANS TEAMING UP IN ONTARIO COMMUNITIES - Pharmacy Connection
working together

  day evaluating the therapeutic         Phillip Chiu, R.Ph., and                is the biggest benefit,” he says.
  relevance of each prescription         Stacy O’Neill, R.Ph.T                   “The technician frees up our time
  and talking to patients, providing     Zehrs Pharmacy, Keswick ON              so that we can spend it with our
  professional services and other                                                patients. Since we are not tied
  medication management func-                                                    down to the counter as much,
  tions (i.e. pharmaceutical opinions    Phillip is standing in the store        we can float around a lot more,
  and MedsChecks);                       of the Keswick, ON Pharmacy             going out to the floor, to approach
• The prescription-filling process      where he has worked for more            patients, to provide them counsel-
   does not slow down.                   than a decade. But he’s not in his      ling. There’s a lot more time to be
                                         usual spot – behind the counter.        proactive with the patients.”
Each of these pharmacies reflect         Rather, he is walking around the
on the pilot and how they have           store’s pharmacy area, approach-        Phillip works with Stacy O’Neill, a
been able to work in a model that        ing patients who look like they         registered pharmacy technician.
maximizes each professional’s work.      may need some assistance in             They have worked together for
These individuals also shed light on     making health-related choices.          more than ten years in this store,
some of the challenges of integrat-      “This is something that I’ve only       where Phillip is the designated
ing technicians – and how best to        been able to do because I have a        manager. When Stacy became
meet them.                               technician on staff – and it really     regulated last year, they integrated

           Loblaw Initiative to
             Integrate Technicians
       The three stores profiled in this article were all   presented. It sought to help staff understand
       part of a pilot program through Loblaw, which        the changes in the pharmacy industry that
       recognizes and supports the expanded role of         necessitated the integration of technicians
       the pharmacist and thus the expanded role of         and provided training on maximizing oppor-
       the technician in pharmacy practice. Loblaw          tunities for delivering professional services.
       recognized that integrating technicians would        Lynn Halliday, an in-house pharmacist for
       require a shift in the way every pharmacy            Loblaw (and non-Council committee member
       employee would think and behave and set out          for OCP), developed and presented training
       to provide support to pharmacies shifting to         strategies aimed at excelling in professional
       this new model. The three pharmacies were            services delivery.
       chosen for the pilot based on the following:
       • They are busy pharmacies with overlapping         Another live training session in June focused
          pharmacists                                       on assessing learning to date and further
       • They had pharmacist staff who were demon-         strategizing on best ways to deliver professional
          strating a good level of support for delivering   services. Further meetings took place last fall to
          professional services to their client base        continue to prepare pharmacy teams on how
       • They employed pharmacists who were willing        to best adapt to new changes in scope with
          to support the integration into the new roles     the technician playing a prominent role in the
                                                            process.
       Since February 2011, the pilot has involved
       regular conference calls with the pharmacies         Since the pilot program began, Loblaw reports
       to discuss the integration of the technicians.       that it more than tripled its prior year results
       In April, a four hour live training session for      with respect to the delivery of professional
       pharmacy managers and technicians was                services, including MedsChecks.

PAGE 10 ~ WINTER 2012 ~ PHARMACY CONNECTION
working together

her into the workflow in such a way
that she, as the technician, takes
care of the technical portion of the
prescription and the pharmacist
checks the prescription for thera-
peutic accuracy at the end of the
process.

It’s a process that pharmacies in the
Loblaw pilot have implemented and
to date it is proving effective.

“Sometimes, the flow gets inter-
rupted when, for example, a patient
may approach me with their
prescription in hand,” says Phillip,
who explains that this requires him
to take care of the therapeutic
portion of the prescription at the
front-end. In reality, the therapeutic
check can take place at any point
in the process, but Phillip prefers
it take place at the end. “There
is some advantage to doing the
therapeutics at the beginning of the
process, but we were finding that
we couldn’t spend as much time
with patients as we need to at the
end because we were simultane-
ously entering information into the
computer.” So Phillip is at the end of
the counter, or floating in the store
to best optimize his role.

As for Stacy’s role, along with
checking prescriptions, she is also
responsible for checking compli-
ance packs and taking telephone            day to day changes to our roles.”          satisfaction. “The new model has
prescriptions from physicians              She admits that adapting to the            allowed me and the other pharma-
and other prescribers. “As the             new model took some time. “There           cists working in the store, to expand
technician, Stacy has become this          was definitely a steep learning curve      the amount of time we have to
incredibly great filter for me. It frees   in getting the whole team on board         engage and interact with patients,
up my time to counsel patients,”           – to have all staff in the dispensary      going more in-depth to their health
says Phillip.                              understand their roles,” she says.         situation than ever before.”
                                           Stacy estimates that it took a good
While Phillip and Stacy have worked        two to three months for all staff          Both Phillip and Stacy agree that
together for some time, they both          in the pharmacy to get on board            the biggest challenge has been
have learned a great deal interact-        with the new model, to understand          changing old habits and creating
ing within this new model.                 Stacy’s role and how it would affect       new ones. Says Phillip: “I know
                                           them.                                      for myself, that when Stacy first
“We didn’t know what to expect                                                        became regulated, I couldn’t help
once I became regulated,” says             For Phillip, the end result couldn’t       but check for technical accuracy
Stacy. “We realized quickly though         have been better. Having a                 while I was doing the therapeutics.
that everyone on the team, not just        technician, in Phillip’s words has         I was so used to checking that part
the two of us had to be ready for          been a source of true professional         of the prescription. But the more

                                                                                  PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 11
working together

we work within this new model, the       Santosh Manjunath, R.Ph., and             of the prescription allows him
more comfortable we are with the         Andrea Ball, R.Ph.T                       and the other three pharmacists
technician’s ability.”                   Zehrs Pharmacy, Brantford ON              on his team to take on more of
                                                                                   the medication management
For Stacy, there were challenges                                                   issues facing patients. “Having the
inherent in learning a new skill and     In Brantford, confidence is the           technician on the team gives us
applying it to real-life situations as   name of the game as technician            more free time which has resulted
well as the challenges in helping        Andrea Ball works alongside               in us spending more time with our
staff to understand the new role of      pharmacist and manager Santosh            patients,” he says.
the technician. “The other clerks        Manjunath in a truly coordinated
had to understand what I was             effort. Having Andrea, a technician       That free time is spent, Santosh
doing – what my role was, and at         on the team, according to Santosh         says, performing MedsChecks, and
times there were some challenges         has made a significant difference.        counselling on a variety of issues
in making those clarifications. But                                                such as smoking cessation, weight
overall the acceptance level with        “I can say definitively that there is a   control and cholesterol monitoring.
them has been very good. Other           major benefit in having a registered
staff have certainly showed interest     technician on the team,” says             “Previously, patients always had to
in my role and in understanding          Santosh. Like his counterparts in         make appointments for this type
the duties that I took over from         Keswick, Santosh points to the            of counselling,” he says. “And while
the pharmacist. Overall, I think         fact that having the technician           appointments make it easier for us
everyone in our pharmacy would           handling the technical portion            to schedule seeing patients, they
agree that it’s been a very positive
situation.”

Do they have any advice for other
pharmacy practitioners that may
want to integrate technicians into
the workflow and don’t know where
to start?

Phillip says it’s all about having an
open mind. “Technicians can really
help you in your practice,” he says.
“And the results are really gratify-
ing – you can see them in terms
of the number of patients that you
can help counsel and to whom you
can provide extra care. It’s great to
have another professional on the
team that can help take away some
of the workload.”

Stacy adds that having support
from other stores involved in the
pilot has helped as has the support
from the management team. “It’s
certainly made the transition easier,”
she says. As for any advice for other
technicians who are integrating into
a new role, she says “Just go for it.
There’s no reason to be reluctant.
It’s a great profession and many
more opportunities to develop.
We’re just getting started.”

PAGE 12 ~ WINTER 2012 ~ PHARMACY CONNECTION
working together

can now walk in and often find me                Having the                            develop their own similar rapport
and my other pharmacist colleagues,                                                    with her and develop their own
available to do these important              technician on the                         relationship.”
procedures and checks. It helps the
patients, and the public at large in        team gives us more                         Andrea’s role in the pharmacy has
monitoring their health issues.”                                                       rubbed off on others: all five of their

Santosh says his role has changed
                                              free time which                          assistants are pursuing regulation.
                                                                                       “I’m so happy for them,” says
dramatically with the technician
on board. “I feel like an advisor/
                                             has resulted in us                        Andrea. “It’s a really good sign – it
                                                                                       shows that in this pharmacy, every-
coach who has directly helped my
patients towards achieving healthy
                                            spending more time                         one is on board and supportive of
                                                                                       the technician role. I think that my
outcomes. It’s very satisfying.”                                                       colleagues can definitely learn from
                                              with our patients                        me and watch with anticipation on
Andrea, a regulated technician who                                                     how they are going to work in their
also volunteers as a non-council                                                       new role.”
committee member with OCP has               says. “But we have been fortunate
worked in pharmacy with Loblaw              to have such a supportive team.            For Santosh, this is all good news
for 16 years –the past 10 with              From the beginning, the staff has          as he continues to build deeper
Santosh. She says that having her           all been very generous and patient         relationships with patients as he
take on more responsibility in the          with the shifts in responsibilities.”      counsels them. “When we spend
pharmacy has contributed to a               Santosh admits that it took him            more time with patients they get
growing bond between patients and           some time to get used to the               to know us by name. For me, that
the pharmacists. “I see a definite          idea of Andrea, as the technician,         means that they walk in and look
increase in the confidence level our        checking the technical aspects of          for me specifically. On a professional
patients have with the pharmacist,”         the prescription. “I couldn’t help it at   level, I feel very satisfied by this.”
she says. “In our pharmacy it’s             first – I was so used to checking the
great because everyone is ready             prescription from a technical basis,       Both Santosh and Andrea point to
to change and accept the different          that it was just natural to continue       the pilot program as an important
roles and responsibilities.”                to do so. But after a couple of            catalyst for establishing their
                                            weeks in the new model, that               workflow and determining the
Like their Keswick colleagues, in this      overlap stopped.”                          new roles in the pharmacy. “Other
setting, the workflow is one that puts                                                 pharmacists in town have been
the pharmacist at the end of the            “I’m very fortunate that Andrea is         asking me how it works and I’ve
process. The technician or assistant is     so capable in her work which gives         been speaking with them to share
responsible for inputting information       me the added confidence of her             the knowledge we’ve had the good
into the system to start the produc-        performing her role,” he says.             fortune to gain from our head
tion required to fill a prescription. The                                              office.”
technician performs the technical           Still, Santosh says, there were
aspect – making sure the right              some bumps along the road as
medication and dose is dispensed            other pharmacy staff became                Hemal Mamtora, R.Ph., Vipul
for the right patient. The pharmacist       accustomed to Andrea’s new role in         Patel, R.Ph., and Kim Lumsden,
comes in at the end of that process         the pharmacy. “In the beginning, the       R.Ph.T.
to provide the therapeutic check and        assistants would avoid consulting          Real Canadian Superstore,
to counsel.                                 with Andrea as a technician. They          Strathroy, ON
                                            were accustomed to coming to
Andrea admits that the process              me directly with questions,” says
wasn’t always smooth and it took            Santosh. “I made it clear that             Hemal Mamtora recalls a recent
some time for all members of the            Andrea was and will continue to be,        phone call he received from a
pharmacy team to be confident               as a regulated technician, respon-         patient. “This patient called me
in each other and the new roles             sible for doing the technical check        to say how grateful he was that I
brought about by regulation. “It            and made them go to her directly.          spent so much time with him to
was definitely a little hard in the         It’s a matter of sticking by those         help assess his diabetes risk,” says
beginning. Everyone’s a bit nervous         rules in order to help everyone’s          Hemal, the pharmacy manager
about taking on a new skill,” she           comfort level. It allowed them to          of the Real Canadian Superstore

                                                                                  PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 13
working together

in Strathroy, ON. “He said he was        technician working on his team –       can now spend time with patients
so surprised by the effort I made        that vital health professional who     and provide counsel to them. It’s
to help him understand his risk          can take responsibility for so many    important to so many different
profile, and how much he learned         duties in the pharmacy – allowing      kinds of patients – for the newly
about his own health as a result.”       Hemal to provide one-on-one            diagnosed diabetic, for example, I
The interaction with this patient,       counselling to patients. “The          can assist with their blood-glucose
says Hemal, was only possible            accessibility that patients now have   monitoring, and be available for
due to the fact that he had a            to me is so valuable,” he says. “I     follow up.”

  Hemal Mamtora, R.Ph.,
  Vipul Patel, R.Ph.,
  and Kim Lumsden, R.Ph.T.
  of Real Canadian Superstore
  in Strathroy, Ontario

PAGE 14 ~ WINTER 2012 ~ PHARMACY CONNECTION
working together

Kim Lumsden is the registered              As a pharmacist, if                     into the workflow and communicate
pharmacy technician in the phar-                                                   that with fellow staff members,”
macy. She has worked there for 13
years. In their pharmacy, Kim is also
                                           you want to move                        he says. “At the same time, the
                                                                                   pharmacist/manager should also be
situated at the point in the process
where the technical check of the
                                           forward and adapt                       able to determine what extended
                                                                                   services he or she is planning to
prescription is completed.
                                          to changes in scope,                     provide to patients.”

Hemal says that within a couple                                                    Vipul Patel, Pharmacy Director of
of months of Kim performing her           then this new model                      Operations for the store, agrees.
new role, he felt confident that he                                                He says it is vital that pharmacists
didn’t have to double check her                is fantastic.                       working with technicians are in a
work. “We have great confidence                                                    unique position to devote more
in her training and ability – she has                                              time to patients, and that they must
really added value to the team.” Kim      with a technician. “Like everything,     plan on how they are going to best
admits that when she first became         communication is critical. Not           use this time. “As a pharmacist,
a regulated technician, there were        all pharmacists may be used to           if you want to move forward and
some challenges in defining her           working with a regulated technician,     adapt to changes in scope, then
role among her colleagues. “The           so it is natural that there may be       this new model is fantastic. It allows
main challenge was to have other          some confusion as to why I’m doing       you to practice your counselling
staff understand my new role. I           what I’m doing. So it’s important to     and hands-on patient care skills.
would say that it took about a            let everyone know how the process        It gives you the time to deliver
month for everyone to understand          works and educating them on what         more patient care. In that, it allows
and be comfortable with who               the technician is responsible for.”      you to grow and change with the
was doing what and who was                                                         profession.” But you have to have
responsible for what,” she says. Still,   Hemal says that for pharmacies           a plan of action, he says. “You need
Kim recalls times when there have         who are thinking about integrating       to plan what you are going to do
been misunderstandings about              a technician into their practice, he     with all this extra time in place. It’s
her role, particularly, for example, if   says it’s important to plan. “You have   a perfect time to expand your role,
there is a relief pharmacist on duty,     to draw up a plan on how you are         your services and get to know your
who may not be used to working            going to integrate the technician        patients and their needs.”

                                                                              PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 15
working together

Integrating Technicians into the workplace

Tips and Reminders
                    Over the past several months, the College has visited
                    a number of pharmacies to understand how the role
                    of the pharmacy technician has been incorporated.

                                          Each visit provided the pharmacy team members
                                          with an opportunity to discuss their successes and
                                          challenges and also seek clarification and feedback
                                          from College staff about their understanding of the
                                          technician role. For College staff, the visits have been
                                          invaluable, allowing us to share collective learning,
                                          correct some misconceptions and encourage others
                                          to benefit from the integration of these new team
                                          members. Although the process and model for
                                          integration of the technician was unique to each
                                          workplace, the discussion and issues were consistently
                                          related to the new role of the pharmacy technician in
                                          the dispensing of a prescription.

                                          Responsibility:
                                          Every professional is responsible for meeting the
                                          standards of practice of their profession.

                                          Technicians are responsible and accountable for the
                                          technical aspects of all prescriptions that they check,
                                          both new and refill. (e.g. the correct patient, product
                                          and prescriber in accordance with the prescription).

                                          Pharmacists remain responsible and accountable for
                                          the therapeutic/clinical appropriateness of all prescrip-
                                          tions, both new and refill.

                                          Accepting Verbal Prescriptions:
                                          Pharmacy technicians are able to accept verbal
                                          prescriptions, with the exception of narcotics and
                                          controlled drug substances.

                                          Once legislative changes to the Food and Drug Act
                                          regulations are in place, pharmacy technicians will also
                                          be able to independently receive and provide prescrip-
                                          tion transfers.

PAGE 16 ~ WINTER 2012 ~ PHARMACY CONNECTION
working together

                                                              technician checks the technical aspects of the weekly
 Independent Double Check:
                                                              compliance packaging and signs for this activity. The
                                                              pharmacist continues to review the profile on a regular
  The requirement to have an “independent double              basis as well as with each new prescription and when
  check” may have been a barrier to the integration           changes are made to any existing prescriptions.
  of technicians in some practice settings. Standards
  of practice for technicians are now in place and
                                                              The common objective of all pharmacies we visited is to
  allow for more flexibility. Whenever possible, a
                                                              increase opportunities to deliver professional services
  final check should be performed by a pharmacy
                                                              such as MedsChecks, Pharmaceutical Opinion Program
  technician (or a pharmacist) who did not enter the
                                                              and Smoking Cessation and to improve the quality of
  prescription into the pharmacy software system or
  who did not select the drug from stock. However,            such interactions. All of the pharmacy teams agreed
  if another member of the team is not available, a           that the pharmacist generally had more time to spend
  final check can be completed by one professional            with patients and this had a very positive effect on the
  providing there are other systems in place to               patient-pharmacist relationship.
  ensure safe medication practices.

                                                              Creating Intra-professional
Work Flow and Processes                                       Relationships

There is no one model that fits all. While the objective      Every site the College visited reported that they began
is to optimize the role of the technician and pharmacist,     to integrate the technician role slowly and cautiously.
workflow will be dependent on physical layout,                Pharmacy technicians acknowledged that they wanted
resources/staffing, patient population/characteristics etc.   time to gain confidence and adjust to the new level of
The pharmacist may best be positioned at the beginning        accountability. They also realized that they needed to
of the workflow process and assess the appropriateness        demonstrate their ability so that the pharmacist could
of the prescription even before the data is entered into      feel confident in letting go of the technical functions.
the computer by the assistant or technician. Alternately
the pharmacist may perform this activity at any time          Pharmacists told us they had to rethink how to perform
during the process or at the end.                             their job and learn how to separate the technical
                                                              and therapeutic functions. For some pharmacists it
Note that the technician cannot release the product           was difficult to see the added value of making these
to the patient until the pharmacist has performed the         adjustments, particularly if the pharmacy technician
therapeutic check. It is important that the pharmacist’s      was not being utilized to their full capacity. Both team
signature is clearly visible on the prescription to allow     members described the importance of being able to
the team to establish that this has occurred. Some            openly discuss their roles and test out new approaches
pharmacies use a stamp to mark the place for the              collaboratively.
pharmacist’s signature.
                                                              The introduction of a pharmacy technician role on the
The pharmacy manager must establish a method of               team also resulted in new relationships with pharmacy
differentiating and preserving the identification of the      assistants. The pharmacy technicians acknowledged the
pharmacist and technician responsible for each prescrip-      challenge of accepting new responsibility for the work
tion. Although signatures are the traditional method of       of others particularly when managing errors. They also
accepting or declaring responsibility, pharmacy teams may     noted how fortunate they were to be in their new role,
wish to utilize other mechanisms within clearly defined       recognizing that the opportunities for these roles have
and understood protocols. Future electronic workflow          been limited. This realization added to the technician’s
processes should consider this requirement.                   sense of responsibility to represent their profes-
                                                              sion well and a desire that their success will lead to
An example of where a protocol could be utilized would        increased opportunities for other regulated pharmacy
be when dispensing within a compliance program. The           technicians.

                                                                            PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 17
Geriatric and
Long-Term Care

18
Report of the             The purpose of the Geriatric and Long-Term Care
                          Review Committee (GLTCRC) is to assist the Office
Coroner’s Geriatric and   of the Chief Coroner in the investigation, review
Long-Term Care Review     and development of recommendations towards the
                          prevention of future similar deaths relating to the
Committee provides        provision of services to elderly individuals and/or
                          individuals receiving geriatric and/or long-term care
recommendations for       within the province.
use of drugs in the
                          Established in 1989, the committee consists of
elderly                   members who are respected practitioners in the
                          fields of geriatrics, gerontology, family medicine,
                          emergency medicine and services to seniors. Elaine
                          Akers, a former OCP council member, is currently
                          the pharmacist representative on the committee.

                          In 2010, the GLTCRC reviewed 11 cases and
                          generated 22 recommendations directed toward
                          the prevention of future deaths. Common issues
                          that the GLTCRC dealt with were:

                          •   edical and nursing management;
                             M
                          •  Use of drugs in the elderly;
                          •   Communication between healthcare practitioners
                               regarding the elderly;
                          • The use of restraints in the elderly; and
                          • Medical/nursing documentation.

                          For the purpose of educating members, we have
                          reprinted one case and recommendations pertain-
                          ing to the use of drugs in the elderly. To read the full
                          report, go to www.mscs.jus.gov.on.ca

                          Case: 2010-01
                          OCC file: 2007-7779
                          Issue:

                          Concerns were identified relating to the care
                          provided in a retirement residence and an acute
                          care general hospital as well the use of narcotics
                          and other medications.

                                      PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 19
GERIATRIC report

Summary:                                                      in impaired drug metabolism, further increasing the
                                                              potential for the development of adverse drug effects.
This was the case of an 83-year-old woman whose
past medical history included: chronic lymphocytic            Records indicated that the decedent received four
leukemia, scoliosis, gastroesophageal reflux disease,         doses of dimenhydrinate over the last two days of her
osteoarthritis with bilateral knee replacements, toe and      life. It was noted by the Committee that dimenhydrinate
bunion surgery, hysterectomy, hernia repair, bilateral        is a drug that is rarely of benefit in the elderly and the
cataract surgeries and an elevated uric acid.                 use of this drug may have further contributed to the
                                                              adverse outcome in this case.
In December 2006, the woman experienced a fall that
resulted in a left wrist fracture, fractured ribs and a       The decedent also developed constipation during the
probable pelvic fracture. It was unclear if the fractured     terminal phase of her illness. While constipation may
wrist was treated with a splint or a cast. It appeared that   present as an overflow diarrhea in the elderly, it was
the fractured wrist remained a significant cause of pain      noted that loperamide hydrochloride should not be
for which her family physician prescribed increasing          prescribed for elderly patients taking opioids. It should
doses of oxycodone hydrochloride. She was also taking         only be given when the diagnosis of constipation has
two different benzodiazepines.                                been properly excluded.

Medical records and documentation relating to the
                                                              Recommendations:
woman’s fall and initial management of her multiple
fractures were not available for review. From the avail-
able medical records, the decedent was already taking         1. Health care professionals should be reminded that
a high dose of oxycodone when she was admitted to                 loperamide hydrochloride should not be prescribed
the retirement home in May, 2007. It could not be                 for elderly patients taking opioids who have diarrhea
determined if alternate management strategies had                 until the presence of constipation has been excluded.
been tried prior to starting the oxycodone (e.g. immo-        2. Health care professionals should be reminded that
bilization of the wrist, local blocks for the fractured           dimenhydrinate is a medication that is rarely indicated
ribs, and regular administration of acetaminophen may             for use in the institutionalized or hospitalized elderly.
have been helpful in decreasing the need for an opioid            The combination of dimenhydrinate with other
analgesic).                                                       psychoactive or anticholinergic medications can
                                                                  result in the development of potentially serious drug
The attending physician attempted to decrease the                 interactions resulting in adverse outcomes.
amount and dosages of medications being given to              3. Health care professionals should be reminded of
the woman. In early June, she developed abdominal                 the importance of using caution when prescribing
distention, nausea and diarrhea. She was treated with             opioids for elderly patients with chronic pain. The
loperamide, dimenhydrinate and a suppository. She                 use of non-pharmaceutical interventions and non-
was subsequently transferred to hospital where she                narcotic medications such as acetaminophen should
was found to be in heart failure. She was admitted and            be considered for use as a first intervention in an
treated with furosemide, dimenhydrinate, morphine,                attempt to minimize the dosage of an opioid required
scopolamine and a Fleet enema. She died in hospital               to control pain.
about 15 hours after arrival.                                 4. Health care professionals should be reminded that
                                                                  the potential toxicity of opioid medications can be
An autopsy found cardiomegaly, valvular heart                     increased by the concomitant use of other psycho-
disease and evidence of congestive heart failure.                 active medications.
Toxicologic analysis found supratherapeutic levels of
oxycodone and diphenhydramine and therapeutic
levels of morphine, lorazepam, acetaminophen and
chlorpheniramine.

It was noted by the Committee that research has
shown that there have been identified risks of using
oxycodone with other psychoactive medications,
including benzodiazepines and dimenhydrinate. It was
also noted that the development of heart failure results

PAGE 20 ~ WINTER 2012 ~ PHARMACY CONNECTION
buprenorphine

Buprenorphine for
the Treatment of
Opioid Dependence
UPDATE ON                                          Buprenorphine has been available as a prescription opioid
                                                   in Canada since 2008. It is marketed as Suboxone® by RB
BUPRENORPHINE FOR                                  Pharmaceuticals, Canada, in combination with naloxone
THE TREATMENT OF                                   in a sublingual tablet. This medication has been available
                                                   for several years in many parts of the world, including the
OPIOID DEPENDENCE                                  United States. In Canada it is indicated for substitution
                                                   treatment in opioid drug dependence in adults.
Laura Murphy, RPh, BScPhm, PharmD
Altum Health, University Health Network, Toronto   Buprenorphine treatment provides an alternative to
                                                   methadone maintenance treatment in Canada. As with
Pearl Isaac, RPh, BScPhm                           methadone treatment, patients prescribed buprenorphine
Centre for Addiction and Mental Health, Toronto    should be carefully monitored within a framework of
Leslie Dan Faculty of Pharmacy, University of
                                                   medical, social, and psychosocial support as part of a
Toronto
                                                   comprehensive opioid dependence treatment program.1
Eva Janecek, RPh, BScPhm
Centre for Addiction and Mental Health, Toronto    Pharmacist involvement in buprenorphine treatment can
Leslie Dan Faculty of Pharmacy, University of      include the supervision of drug administration, monitor-
Toronto
                                                   ing patients, communicating with the treatment team,
Anne Kalvik, RPh, BScPhm                           providing encouragement and support, and dispensing
Centre for Addiction and Mental Health, Toronto    take-home doses (‘carries’).
Leslie Dan Faculty of Pharmacy, University of
Toronto                                            Involvement in the treatment of opioid dependent patients
                                                   with buprenorphine has the potential for pharmacists to
Sarah Woodworth, RPh, BSc(Pharm)
Leslie Dan Faculty of Pharmacy, University of      expand their scope of practice and provide a satisfying
Toronto                                            professional opportunity to participate in the recovery
                                                   of individuals dependent on opioids. This area of practice
Beth Sproule, RPh, BScPhm, PharmD                  may be of particular interest to those pharmacists involved
Centre for Addiction and Mental Health, Toronto
                                                   in the provision of methadone maintenance treatment.
                                                   Opioid dependence is a complex disorder; therefore
                                                   pharmacists who take training specific to buprenorphine
                                                   therapy and other treatment options will be best able to
                                                   provide pharmacy services to these patients.

                                                   With buprenorphine maintenance treatment, as with
                                                   methadone maintenance treatment, patients benefit from
                                                   physicians and pharmacists working together effectively to
                                                   provide optimal treatment.

                                                   Recently, clinical practice guidelines were developed by
                                                   the Centre for Addiction and Mental Health (CAMH)
                                                   to provide clinical recommendations for the initiation,

                                                                     PHARMACY CONNECTION ~ WINTER 2012 ~ PAGE 21
buprenorphine

maintenance and discontinuation                  injecting, but does not eliminate   Narcotics Safety and Awareness Act,
of buprenorphine/naloxone                        the risk.                           2010, as part of Ontario’s Narcotic
maintenance treatment in the                  - c an be titrated to a stable        Strategy for monitored drugs.14
ambulatory treatment of adults and               dose within days, in contrast
adolescents with opioid depen-                   to methadone which typically        The new Guidelines highly
dence in Ontario.2 Information                   may take weeks to achieve the       recommend that pharmacists
in this article has been updated                 optimum dose.                       who provide buprenorphine
from its first appearance in OCP              -p  rescribed at maximal doses        services undertake training. These
Connection (Jan-Feb 2008) to                     may not be sufficient for all       pharmacists must be aware of the
reflect these new guidelines. The                patients. When the maximum          unique nature of buprenorphine
Guidelines are available from the                daily dose does not stabilize a     dispensing and specific issues that
CAMH, OCP or CPSO websites,                      patient, consideration should be    exist in dispensing medications
and should be reviewed before                    given to using methadone.           for the maintenance treatment of
dispensing buprenorphine.                     -m  ay induce withdrawal in           substance dependence. Training
                                                 patients dependent on opioids if    resources are included at the end
                                                 administered too soon after last    of the article.
Key Messages for                                 use of full opioid agonist.
Buprenorphine                                 -h  as also been successfully
                                                 used for medical withdrawal         How Buprenorphine
•   uboxone® is an opioid prescrip-
   S                                             treatment (detoxification) from     Works
   tion medication containing                    opioids7,12 and for the treatment
   buprenorphine 2 mg and 8 mg                   of pain13 (both are unapproved
   (in sublingual tablets) in fixed              indications in Canada).             Buprenorphine is a synthetic opioid
   combination with naloxone 0.5                                                     with a unique profile: it is a partial
   and 2 mg respectively (to deter                                                   mu-opioid receptor agonist.1
   injection drug use).                     Regulatory Framework                     Buprenorphine has a lower intrinsic
• Sublingual dissolution of                for Buprenorphine                        activity at the mu-opioid receptor
   Suboxone® sublingual tablets                                                      than a full agonist (e.g., methadone
   usually takes 2 to 10 minutes.           Buprenorphine/naloxone does              or oxycodone). This means that
• Buprenorphine:                           not require a special prescribing        there is a “ceiling effect” to its opioid
 - is efficacious as substitution         exemption, unlike methadone, so          agonist effects at higher doses15
      therapy in the treatment of           prescriptions may be written by any      making it safer in overdose and
      opioid dependence.3-5                 practitioner licensed to prescribe       reducing its potential for abuse.
   - is an alternative to, but not         narcotics. The College of Physicians     In addition, there is little increase
      a substitute for, methadone           and Surgeons of Ontario (CPSO)           in efficacy with doses above 16-32
      maintenance treatment.6               expects all physicians who wish          mg daily. Although it is a partial
   - acts primarily as a partial agonist   to use buprenorphine to treat            agonist, buprenorphine has a very
      at mu-opioid receptors.1              opioid-dependent patients to have        high affinity for (i.e., binds tightly
   - is considered safer in overdose       training/education on this drug,         to) the mu receptor. This tight
      than methadone, although              and addiction medicine generally,        binding means that buprenorphine
      if combined with other CNS            prior to initiating buprenorphine        can block the effects of other
      depressant drugs (e.g., benzodi-      treatment.                               opioid agonists (e.g., methadone
      azepines) respiratory depression                                               or oxycodone), and precipitate
      can occur.7 If clinical symptoms      Prescriptions for Suboxone® have         withdrawal in those physically
      of overdose occur, higher doses       the same requirements as other           dependent on opioids by displacing
      of naloxone or other measures         "straight narcotics", however, in        agonists from opioid receptors.1
      for treatment may be required.8       addition it would be good practice       The tight binding is also associated
   -m  ay have a lower potential           to also indicate:                        with a slow dissociation from the
      for abuse and dependence              • start and stop dates                  mu receptor resulting in a long
      than pure agonists such as            • days for supervised administration    duration of action.1 This is why
      morphine9-10, although abuse          • days for take home doses              buprenorphine is associated with
      does occur.9-11 The addition of                                                a milder withdrawal syndrome and
      naloxone to the Suboxone®             As with other opioids, dispensing        has been used to assist in detoxifi-
      product formulation is intended       procedures for buprenorphine/            cation from other opioids.7,12
      to further reduce the risk of         naloxone must comply with the

PAGE 22 ~ WINTER 2012 ~ PHARMACY CONNECTION
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