Blood donors and donations in Italy at the time of COVID-19 - Vincenzo de Angelis MD
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Blood donors and donations in Italy at the time of COVID-19 Vincenzo de Angelis MD Transfusion Medicine Dept University Hospital "S. Maria della Misericordia" Udine - Italy
As to April 18th, the infected people in Italy rose to 175,825 (+3,491 compared to 17th, + 2%), including 44,927 people recovered (+ 2,200 compared to 17 th + 5%) and 23,227 died (+482 compared to 17th + 2%). The currently positive people are therefore 107,771 (+809 compared to 17th + 0.8%). Globally, Lombardy, Veneto and Emilia-Romagna represent ¾ of the cases (Official data from MOH).
Consequence of SARS-CoV-2 spread 1) The Italian Health System had a high percentage (9-11%) of infected patients being admitted to Intensive Care Units (ICUs) rapidly saturated 2) Government Decrees on limitation measures produced an initial DECREASE in blood donations 3) Hospitals have responded by drastically reducing the non-urgent surgical and medical admittance 4) This was responsible for a DECREASE of blood utilization
Blood donation is included in the list of “urgent and essential activities” allowing the people to leave their houses
Red Blood Cells Production / Distribution in Italy March 2- April 12 A national media campaign (media, MoH, donors’ Associations…) on the importance 7 and safety of blood donation, call for donations 6 59032 53539 5 46183 45117 44297 4 39745 40332 36251 37221 34930 32906 3 30673 Reorganization of hospital 2 activity 22871 13793 1 0 2-8-1866 9-15... 16-22... -2291 23-30... 31 mar 5... 6-12... -7426 -1 -14444 -2 RBC Collected RBC distributed difference Data from CNS
Consequences - Measures 1) excess in blood inventory, common to many past disasters 2)overcrowding observed in donor centres difficult to guarantee a safe social distance Pressure to implement better planning Moving donors to schedule donations A more organized flux of people (for donor and staff safety) A more rational management of the blood inventory .
RBC Collection and Distribution during the period March 2- April 12 (per Region) 10000 9000 9000 8000 8000 COLLECTION DISTRIBUTION 7000 7000 6000 6000 5000 5000 4000 4000 3000 3000 2000 2000 1000 1000 0 0 ta te ia ia to no lia to na na ia he io na zo i a s e lia ta ia lia ta te ia ia to no lia to na na ia he io na i a s e l ia os on igur ard ren lza Giu ene ag sca mbr arc Laz eg ruz pan oli ug lica labr Sici zo ta ia l ia A rd Ab m P si os on igur ard ren lza Giu ene ag sca mbr arc Laz eg ruz pan oli ug lica labr Sici d' iem L mb di T i Bo i V. V om To U M M Ca A d' iem L m b i T B o V. rd Ab m M P i lle P Lo PA R Sa Ca Ba V om To U M Sa s Ca a d iul i a lle P Lo PA d di iuli R Ca Ba V PA Fr il V a PA Fr il i a Em Em 2 - 8 marzo 2020 9- 15 marzo 2020 16- 22 marzo 2020 2 - 8 marzo 2020 9- 15 marzo 2020 16- 22 marzo 2020 23- 29 marzo 2020 30 marzo- 5 aprile 2020 6 aprile -12 aprile 23- 29 marzo 2020 30 marzo- 5 aprile 2020 6 aprile -12 aprile Data from CNS
Emergency COVID-19 – Emilia Romagna • 1° week: decrease by 5% blood donations; then call for donations (National and Regional MoH, Donors’Associations, social media...) increase and also surplus of blood donations. Recommendations to Blood Centres by Regional Authority (March 13th) • Plan measures (only scheduled donations) to allow regular/constant access of donors to the collection sites, and to respect social distancing. • Plan activities aimed at ensuring collection of blood also in forthcoming weeks (shortage expected on April/May after the huge collection of March) • Safety measures (common, see later) • Appropriate use of blood (PBM, restrictive transfusion triggers, early recall of untransfused units after surgery – not later than 12 hr) • First time retested donor common practice in Emilia Romagna: Donors’ Association asked to plan the recruitment of candidate donors in the next months (courtesy Blood Coordinating Authority, dr. V. Randi, Bologna)
Emergency COVID-19 – Lombardia (the most affected Italian Region: half of the deaths recorded here) Collection: weekly decrease by 20% (February 24 to March 15), decrease by 14% in the following weeks (after call for donation) from March 16 to 22 and huge decrease (40% ) from March 23 on Distribution: progressive decrease from February 22 on (higher decrease > 30%, average 25 %); now up-turn (last week) in distribution (to be confirmed) Emergency inventory of the region (II + III level emergency) in normal conditions: 500 units; doubled from February 25th to March 6th and stable till march 16; then increased (unwilling) up to 6 times, stable on these high levels till the first week of April, then progressively decreasing and coming to normal levels now. ACTIONS Plan blood collection sessions and Schedule donations; share the inventories among regional Blood Centers (=computerized regional unique inventory) Decrease, in the short term, regional blood collection program by 30 % as compared to the plan pre-COVID-19. (courtesy Blood Coordinating Authority, dr. R. Chianese, Milan)
Emergency COVID-19 - Veneto The first Italian region (together with Lombardia) where the SARS-CoV-2 spread has been recorded (February 22). Dramatic decrease in blood donations and then rapid increase due to a big pressure on public opinion (by national and Regional MoH, Civil Protection, Blood Donor Associations, National Health Institute…). Increase of blood distribution during last week (increased hospital activity) and expected shortage in the forthcoming months, when hospitals will rise activities at a regular level ACTIONS • Daily monitoring of collection/distribution in the region by the regional blood coordinating authority and information to all Transfusion Depts (to share the inventories among regional Blood Centers) • Fixed amount of donors allowed by each session of blood collection, reservations required; planning reduction of activity in some collection sites on weekends (measures to prevent the spread of the infection) • All these measures reduced the elimination of outdated units to a minimum; the situation requires a reorganization of the relationships between transfusion facilities and donor associations for a better dynamism and a faster adaptation of collection programmes. Weeks March 2- March 9- March 16- March 22- March 30 April 6 - 8 15 22 29 Apr 5 12 RBC 4299 4769 5716 3673 3222 2842 Collected RBC 4369 4000 3628 3812 3980 4478 Distributed (courtesy Blood Coordinating Authority, dr. G. Roveroni, Padova)
Emergency COVID-19 - Piemonte 1) Shortage at the beginning (March 3 to 9), due to restrictions in people’s movement; in some instances Health Authorities did not allow blood sessions on mobile units 2) Then call for donations (National and Regional MoH, Donors’Associations, social media...) increase and also surplus of blood donations, also due to drastic reduction of hospital elective activities (surgical and medical) 3) Now situation back to normal, as a consequence of regular organization of planned donor sessions with scheduled donations 4) A maintenance of regional self-sufficiency and a regular supply of blood to other regions (Sardinia) is expected in the next weeks/months. (courtesy Blood Coordinating Authority, dr. F. Ripa, Torino)
Post Donation Information: How to deal with Post Donation +ve Onset of close Total Informations / swabs symptoms contact PDI Region * (February 22- April 12) Veneto 10 69 20 99 Friuli-VG 4 10 8 22 Emilia 9 104 35 148 Romagna Lombardia 23 286 58 367 Piemonte 3 9 23 35 Total 49 478 144 671 *following ECDC definition
GENERAL RECOMMENDATIONS TO PREVENT SARS-COV-2 DIFFUSION
1. Schedule donations and do “triage” when scheduling 2. Limit the number of donors in waiting rooms 3. Sanitize hands of donors before donation 4. Surgical mask to donors 5. Distancing of chairs and beds 6. Surgical mask, protective visor to staff 7. Contact limited in time (close contact staff/donor < 15 ‘) 8. Staff change gloves after every donation (also before SARS-CoV-2) 9. If possible, put a screen in Front-office conditions (open environments) 10. Sanitize rooms/mobile units after use SPECIFIC RECOMMENDATIONS FOR BLOOD SESSIONS
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