Statin pretreatment and presentation patterns in patients with acute coronary syndromes
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Brief Report
Page 1 of 5
Statin pretreatment and presentation patterns in patients with
acute coronary syndromes
Marcelo Trivi, Ruth Henquin, Juan Costabel, Diego Conde
Cardiovascular Institute of Buenos Aires, Buenos Aires, Argentina
Correspondence to: Marcelo Trivi. Blanco Encalada 1543, Buenos Aires 1428, Argentina. Email: mstrivi@icba.com.ar.
Abstract: Statin therapy stabilizes coronary plaque, and it could be associated with less ST elevation
myocardial infarction (STEMI) and acute myocardial infarction (AMI) [which includes, STEMI + non-
STEMI (NSTEMI)], among patients presenting acute coronary syndromes (ACS). The aim of this study was
to determine any association between prior use of statins and presentation patterns in 1,322 ACS patients
admitted between 2014 and 2016: STEMI [247], NSTEMI [461] or unstable angina (UA) [614]. Coronary
risk factors, history and chronic use of statins, aspirin and beta blockers were collected. Uni, multivariable
and propensity score analysis were performed. About half (46%) of the patients received statins but only
14% high doses. UA patients received more statins and higher doses =335 (54%)/117 (19%) compared to
NSTEMI =189 (40%)/49 (11%), and STEMI =77 (31%)/21 (9%), PPage 2 of 5 Journal of Xiangya Medicine, 2017 Table 1 Clinical characteristics and presentation of ACS Variable STEMI [247] NSTEMI [461] UA [614] P Age 64±11 68±13 68±11 0.0001 Female 48 (20%) 105 (23%) 168 (27%) 0.0032 Hypertension 142 (57%) 297 (64%) 439 (71%) 0.0001 Hypercholesterolemia 161 (64%) 369 (80%) 475 (77%)
Journal of Xiangya Medicine, 2017 Page 3 of 5 Table 2 Clinical characteristics and use of statins prior to admission Discussion Variable Statins [601] Statins naive [721] P A C S usually occurs as a result of a rupture of an Age 68±11 66±12
Page 4 of 5 Journal of Xiangya Medicine, 2017
Table 3 Multivariable predictors for STEMI and AMI
STEMI AMI
Parameter
Odds ratio 95% CI P (>|Z|) Odds ratio 95% CI P (>|Z|)
Age 0.986 0.973–0.999 0.0364 1.002 0.992–1.013 0.627
Gender (male) 1.515 1.055–2.176 0.0246 1.617 1.234–2.120 0.0005
Hypertension 0.672 0.486–0.927 0.0156 0.764 0.578–1.010 0.0583
Hypercholesterolemia 0.852 0.612–1.185 0.3417 0.810 0.613–1.069 0.1371
Smoking 1.474 1.079–2.015 0.0149 1.035 0.814–1.315 0.7785
Diabetes mellitus 0.860 0.581–1.273 0.4525 1.002 0.756–1.328 0.9901
Family history 0.818 0.572–1.171 0.2729 0.743 0.565–0.978 0.0342
Prior MI 0.921 0.612–1.385 0.6914 1.032 0.775–1.375 0.8283
Prior angioplasty 0.487 0.317–0.746 0.001 0.567 0.426–0.754Journal of Xiangya Medicine, 2017 Page 5 of 5
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doi: 10.21037/jxym.2017.08.01
Cite this article as: Trivi M, Henquin R, Costabel J, Conde D.
Statin pretreatment and presentation patterns in patients with
acute coronary syndromes. J Xiangya Med 2017;2:65.
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