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NEWS OF THE TEXAS MEDICAL CENTER — VOL. 6 / NO. 1 — FEBRUARY 2019 Saving Officer Barnes John Barnes confronted the shooter at Santa Fe High School, p. 20 DATING APP TAPS GENETICS AND SOCIAL MEDIA, p. 7 THE FUTURE OF HEART HEALTH, pp. 28–33
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President’s Perspective treatment at the Texas Medical Center are often facing TMC | PULSE a difficult time. A simple act of kindness means a great Mark Mulligan/© Houston Chronicle. Used with permission. Vol. 6 No. 1 deal to a family receiving care. February 2019 As president and CEO of the Texas Medical Center, I am often asked: “What keeps you up at night?” My President and Chief Executive Officer answer is always: “The safety of everyone that comes William F. McKeon to the medical center each day.” In our ever-changing Communications Director social landscape, sadly, this concern is elevated. Ryan Holeywell Over the last year, we increased the presence of TMC Police considerably across the campus to Pulse Editor maintain and enhance the safety of our employees and Maggie Galehouse mgalehouse@tmc.edu WILLIAM F. McKEON visitors. This spring, we will open a new TMC Police President and Chief Executive Officer station at the center of the campus at the intersec- Assistant Editor Texas Medical Center tion of Holcombe and Bertner. This will enhance our Cindy George visibility, capabilities and the speed at which we can cgeorge@tmc.edu respond to events that warrant police attention. Staff Writers E very morning, I wake up very early and read the TMC Police report that covers all of the activities from the previous day and evening. It is fascinating to The TMC Police work very closely with the police and security departments of our member institutions, as well as the Houston Police Department, county Alexandra Becker Britni R. McAshan Shanley Pierce see, in one document, all that transpires in 24 hours sheriff’s offices, FBI and CIA. Each of these entities Photojournalist across the 1,400 acres of the largest and busiest plays a critical role in protecting and supporting the Cody Duty medical city in the world. medical center. I will never fully rest easy, as potential Members of the TMC Police and Security team threats are ever-present. I do, however, find more NEWSROOM are recruited and trained to protect and serve the comfort as we enhance our collaboration and 713-791-8812 110,000 employees of the medical center and the communications across this amazing medical city. news@tmc.edu millions of patients and their families we care for each ADVERTISING year. They do so with great pride, recognizing that the Felicia Zbranek-Zeitman people who come from around the world to receive 713-791-8829 newsads@tmc.edu DISTRIBUTION Wallace Middleton distribution@tmc.edu READ US ONLINE tmc.edu/news FOLLOW US @TXMedCenter @texasmedcenter @thetexasmedicalcenter TMC Pulse is an award-winning monthly publication of the Texas Medical Center in Houston, Texas. Permission from the editor is required to reprint any material. The exterior of the TMC Police station, left, is reflected in a glass barrier wall. 2 tmc » p u l s e | f e b r u a r y 2 01 9
Table of Contents 4 14 34 36 Juul Ad Campaign New HQ for Visit to Dentist Leads How Are We Targets Adult Smokers TMC Police to Heart Diagnosis Most Likely to Die? 6 Curated: The First Time, The Heart (A Portrait of Life 1854-1913) 10 Spotlight: Todd Rosengart, M.D. 15 Vitals: 2019 Predictions 19 Next Med: Mending a Hole in the Heart 38 Field Notes 40 Calendar on the cover: John Barnes was on duty as a school resource officer at Santa Fe High School when a shooter opened fire. on this page:Cool Acres, the family ranch of cardiovascular pioneer Denton A. Cooley, M.D., was home to the St. Luke’s family picnic, p. 16.
Juul Ad Campaign Targets Adult Smokers Medical experts remain concerned about the adolescent vaping epidemic By Shanley Pierce A lthough popular e-cigarette manufacturer Juul has launched a new ad campaign aimed “There is no doubt that, if you have to choose between smoking a combustible cigarette and using at adult smokers, medical experts an e-cigarette, using a regulated remain skeptical of the company’s e-cigarette is actually safer. intended audience and concerned There’s no doubt it has harm- about the spike in adolescent reduction potential,” said U.S. vaping. Surgeon General Jerome Adams, Earlier this year, Juul released M.D., during a recent visit to The a series of 60-second television University of Texas MD Anderson commercials featuring testimonials Cancer Center. “I’m not against from adult smokers who “made the preserving e-cigarettes and vaping switch” to Juul. Ads have also been as an option for adults who want to released online, on the radio and quit smoking, but I absolutely in print. want people to understand that “Our success ultimately depends for young people, this presents a on our ability to get our product in very unique danger.” the hands of the adult smokers and It took decades to change out of the hands of youth,” the com- U.S. Surgeon General Jerome Adams, M.D., displays a Juul device during a recent young Americans’ minds about pany said in a press release. “When visit to The University of Texas MD Anderson Cancer Center. combustible cigarettes, Adams adult smokers try it, it works. And, said, and e-cigarettes have clouded the impact is life-changing.” parties. The ads are playing up this company for deliberately targeting that success. E-cigarettes were initially New York City lifestyle and they’re its products to minors by luring “It took us a long time to deal introduced to the market to offer super fun,” Morain said. “Now you them with a variety of whimsical with advertising and marketing adult smokers a safer alternative to see their Twitter campaign and it flavors, including cool mint, crème to help turn the tide so youth no combustible cigarettes and to wean reminds me of a tombstone ad … brûlée and cool cucumber. longer thought [combustible them off of their tobacco addiction, with very stark, black and white Juul spent approximately cigarettes] were cool. We’re now to but adolescents jumped on the vap- text. What they’re saying is more $10 million on television ads, which a point where, if you talk to most ing bandwagon. The rise in adoles- politically palatable and signaling air on cable channels after 10 p.m., kids, they’ll tell you it’s not cool to cent vaping from 2017 to 2018 was an olive branch, but it doesn’t seem according to Juul spokesman Ted smoke,” Adams said. “Unfortunately, the largest recorded in the past like they’re bringing the same mar- Kwong. The company is flush with with e-cigarettes, kids—like my 43 years for any adolescent sub- keting power to those types of ads, cash after major tobacco producer own son who thought that these stance use outcome in the United which makes me a little skeptical Altria, which manufacturers just contain flavored water—think States, according to the National about how genuine this effort is.” Marlboro, acquired a 35 percent they’re safe and cool. They’re being Institutes of Health’s annual Juul’s about-face comes on the stake—worth nearly $13 billion—in marketed to them through YouTube, Monitoring the Future survey. heels of a difficult year. Throughout the e-cigarette startup at the end of video games, music videos that kids Stephanie Morain, Ph.D., an 2018, Juul came under intense fire 2018. According to Altria, the invest- watch. It shows that some of these assistant professor at the Center for from public health experts and ment places Juul’s market value at companies are, in fact, directing Medical Ethics and Health Policy federal regulators, who criticized the $38 billion. their marketing toward children.” at Baylor College of Medicine, com- pared Juul’s original ads with the The challenge for regulation is that we’re really trying to thread somber, no-nonsense ads of the new campaign. the needle and ensure youth aren’t getting access to these products, “If you look back to 2015, you while adult smokers who would use them to transition or ideally to quit see these beautiful ads with bright altogether would still have access. colors and individuals who look like they’re maybe 18 to 24 at these — STEPHANIE MORAIN, PH.D. Assistant professor at the Center for Medical Ethics and Health Policy at Baylor College of Medicine 4 tmc » p u l s e | f e b r u a r y 2 01 9
Juul claimed that its flavors, raising the tobacco-buying age to processes for online purchases. adolescents. E-cigarette use, in con- social media marketing and original 21 and invest $30 million over the “I think this is overdue,” Morain trast, surged to staggering propor- ads from 2015 weren’t intentionally next three years to fund indepen- said. “The challenge for regulation tions. The percentage of American designed to attract teenagers; how- dent research, education and com- is that we’re really trying to thread high school seniors who said they ever, beginning in April 2018, the munity outreach initiatives. the needle and ensure youth aren’t vaped in the past year jumped from U.S. Food and Drug Administration In November 2018, the FDA getting access to these products, 27.8 percent in 2017 to 37.3 percent (FDA) turned up the heat by placing announced new steps in response while adult smokers who would use in 2018. The percentage of high Juul under federal investigation. to the astronomical surge of them to transition or ideally to quit school seniors who vaped nicotine Later that month, FDA e-cigarette use among teens. altogether would still have access.” within a month before the survey Commissioner Scott Gottlieb Stopping short of a full ban on At the end of 2018, Adams issued nearly doubled, soaring from 11 per- announced that the agency had most flavored e-cigarette sales in the Surgeon General’s Advisory cent in 2017 to 20.9 percent in 2018. uncovered a litany of violations in retail stores and gas stations across on E-Cigarette Use Among Youth, “The meteoric rise in the use of e-cigarette sales to underage teen- the country—an idea many health only the fourth Surgeon General’s e-cigarettes among our young peo- agers and requested that Juul sub- experts and parents supported— Advisory in the past 13 years. ple,” Adams said, “rose to the level mit company materials, including the agency decided instead to issue His announcement drew data that I felt that I had no choice but to marketing documents and research new rules that limit sales to age- from the Monitoring the Future declare it an epidemic. targeting different age groups. In restricted locations and require survey, which reported a decrease response, Juul said it would support more robust age-verification in opioid and alcohol use among tmc » p u l s e | f e b r u a r y 2 01 9 5
To create the images, Robleto essentially The Intersection of ARTS and MEDICINE designed a new form of printing. He put By Britni R. McAshan high-resolution scans of the images onto an uncoated machine-finished paperboard. The photo- lithographs were then transferred with transpar- ent base ink onto hand- flamed and sooted paper, brushed with lithotine and fused in a mild solution of shellac and denatured alcohol. “The heart is the only organ in our bodies that we can actually feel and, as a cultural metaphor, it will not budge,” Robleto said. “Even though science Credit: Courtesy of Inman Gallery moved on to the brain a long time ago, culturally, it doesn’t matter. We still give our hearts to one another. The brain isn’t the symbol on Valentine’s Day … it’s the heart.” But as science moves forward, the cultural impli- I n 1977, NASA launched Voyager 1 and 2 into the far reaches of outer space. Secured on the side of each space probe was a copy of the Golden He found the first pulse tracing of a heartbeat, completed in the 1850s—half a century before the birth of electrocardiography. A German doctor cations of heart transplants, regenerative medi- cine and technology must be considered. Robleto has spent time with the Texas Heart Record—an interstellar message-in-a-bottle filled used soot from a candle flame gathered on a piece Institute’s Doris Taylor, Ph.D., who is working on with greetings in multiple languages, along with of paper and human hair to trace the beat of his stripping a pig heart and re-cellularizing it with images and sounds of nature to communicate own heart. human DNA. He also has consulted with William with other life forms in the galaxy. The black and white images on display at “Billy” Cohn, M.D., and the Texas Heart Institute’s But it was the final message in the Golden Inman Gallery are recreations of original tracings O.H. “Bud” Frazier, M.D., who are working with Record that transfixed young Dario Robleto, a produced between 1854 and 1913. They document Daniel Timms, Ph.D., to develop the BiVacor, a local artist and citizen scientist. Decades later, it the heart’s reaction to everything from riding a total artificial heart with no pulse. inspired his work, The First Time, The Heart (A bike to smelling lavender to feeling scared. “Can we assume our hearts will always sound Portrait of Life 1854–1913), photolithographs on “There was a quest to image the invisible—the the same?” Robleto asks. “In all of human history, permanent display at Houston’s Inman Gallery. invisible being the most complicated organ in the no one has ever proposed that you don’t need a Ann Druyan, creative director of the Golden body—and to use hair and soot to image it for the pulsatile heart to be a human, and it is a game Record project, was in love with Carl Sagan, the first time is so beautiful to me,” Robleto said. “It changer. There is a cultural dynamic to the idea late astronomer and author who was leading the is a history of materials as much as it is a history of letting go of our heartbeats and I think that is a group at NASA. Druyan’s final message on the of cardiology.” fascinating question to pursue.” Golden Record was a one-minute recording of her brainwaves as she thought about her love for Sagan, whom she later married. “Her heart is the only heart that has actually exited our solar system,” Robleto said. “I love that both her heart and her brain are represented, The First Time, The Heart (A Portrait of Life 1854–1913) because she’s arguing: Is love in there and can it is part of the permanent collection at Inman Gallery, be deciphered at a later date?” 3901 Main St. Information: 713-526-7800. Robleto realized that to honor Druyan’s story and fully understand the cultural, physical, his- Above: Dario Robleto’s photolithograph of torical and scientific significance of the heart, he First Pulse, 1854, retraced the original image using needed to take a retrospective look at the origins ink, hand-flamed and sooted paper, lithotine, shellac of the first heartbeat recorded in history. and alcohol. Left: Robleto holds one of his prints at Inman Gallery. 6 tmc » p u l s e | f e b r u a r y 2 01 9
Dating App Taps Genetics and Social Media Scientists offer a new recipe for love By Britni R. McAshan physical chemistry and social compared to our own because that rapport. “It’s nothing like designer means that we are not related, so we babies or anything like that. It is, will have a decreased risk of genetic essentially, how do your genes affect disease in our progeny and our who you are attracted to and who progeny will have a more diverse set you jive with the best? How is that of immune system genes and there- inscribed in your genome?” fore be immune to more pathogens,” Nearly a decade and a Ph.D. Barreto explained. from Baylor College of Medicine Animals also prefer mates with later, Barreto set her plan into complementary immune systems action. While attending a workshop and communicate this information hosted by Enventure—a grassroots through olfactory cues. The genes life science startup community in associated with their immune sys- Houston—she met Bin Huang, Ph.D., tems are tethered to pheromones, who became the co-founder and chemicals animals produce and chief technological officer emit that influence all sort of behav- of Pheramor. ior among others in their species— “I pitched the idea at their including sexual attraction. accelerator program and Bin, who But there is no hard science on was a doctoral candidate at Rice humans releasing or picking up University at the time, also pitched on pheromones, in part because an idea, but then at the end, when we animals use the vomeronasal organ had to make teams, he came up to (VNO)—a gathering of sensory cells me and said, ‘Forget my idea, I want in the nasal cavity above the roof of to do your idea,’” Barreto recalled. the mouth—to detect pheromones, “I know the genetics behind attrac- and humans do not have a function- tion and Bin knows the techy side ing VNO. ➟ and he is on the back end writing the algorithm that is literally matching people.” Pheramor brings couples together after analyzing a seg- ment of each candidate’s human leukocyte antigen (HLA) gene Brittany Barreto, Ph.D., is the CEO and co-founder of Pheramor, a dating app. complex—proteins that regulate the immune system—and social media history. It is one of a Y ears before she became a genetic scientist, Brittany Barreto dreamed of creating a handful of companies launched over the past decade that uses genetics to determine romantic way for people to find love compatibility. through DNA. The HLA complex helps the “I just thought it would be so immune system distinguish cool to connect people on a roman- the body’s own proteins from pro- tic level using their DNA,” said teins made by foreign invaders, Barreto, co-founder and CEO of such as viruses and bacteria. Pheramor, a dating app that aims “We are seeking a partner that to measure compatibility using has a different immune system tmc » p u l s e | f e b r u a r y 2 01 9
It’s nothing like designer babies or any- thing like that. It is, essentially, how do your genes affect who you are attracted to and who you jive with the best? How is that inscribed in your genome? — BRITTANY BARRETO, PH.D. CEO and co-founder of Pheramor That’s why Pheramor takes a Pennsylvania, told Wired magazine: cheek swab from clients for DNA “The notion that there are these sequencing, rather than try to magical genes that are somehow link human attraction to smell. associated with smells that perme- (Confusingly, though, the compa- ate the environment and dictate ny’s name merges “pheromone” our attraction to people is total with “amor,” the Spanish word nonsense. If human pheromones for love.) As the company notes actually elicited the kinds of behav- on its website, pheramor.com: iors we see in other mammals, the “Pheramor fully appreciates that subways of New York City would be the science of pheromones requires in a constant state of mayhem with more research.” people hopping all over each other.” Rapid Response Pheramor also recognizes Barreto and Huang launched that humans are highly social. To the Pheramor app officially in account for this in the matchmak- September 2018. Wound Care. ing process, the team at Pheramor “We have thousands of active analyzes candidates’ social media users and have grown 50 percent histories before they are matched month over month,” Barreto said, with potential suitors. but declined to disclose the compa- Whether it’s a severe wound to the lower extremities or “Humans are a more compli- ny’s revenue. a small sore or blister that just won’t heal, Doctor Randal cated animal,” Huang explains. Once users download the app, “Fifty percent is genetics, but the they receive a DNA kit, do a cheek Lepow has the solution. He is Board Certified in Wound other 50 percent is what do you swab, return the kit and wait for their Care and knows the importance of fast intervention and like to do? What are your common sequencing to be done. treatment. He is available to consult with in-hospital interests? We try to extract this “The app is free, but we charge patients or on an outpatient basis. information from your social $30 for the DNA testing,” Huang media data because we don’t explained. “The processing time want people to answer everything for the kits takes 21 business days, Don’t let a small wound turn into a big problem. themselves.” but the processing for us can take Antibiotics alone usually aren’t the answer. Contact our Some research supports around one month.” office today to arrange a consultation. Pheramor’s DNA matchmaking. The DNA kits are processed at a A 2016 study published in Scientific lab and then returned to Pheramor. Reports found that the HLA com- Once the data has been collected, plex mediates mate behavior in users gain access to six profiles humans and that subjects were per day on the app. The profiles generally most satisfied with are weighted based on physical their relationship if their partner proximity of clients first, then on the exhibited a dissimilar HLA type. gender and age each client speci- Researchers found that HLA dissim- fied. If two people like each other’s ilarity correlates with partnership, profiles, they can begin messaging sexuality and enhances the desire one another. to procreate. In the four months the Pheramor But among scientists, the idea app has been live, more than 40+ years of experience of human pheromones remains a 5,000 messages have been shared Board Certified, American Board of Foot and Ankle Surgery hard sell. In 2018, Richard Doty, a between users and 20 couples have professor of otorhinolaryngology deactivated their accounts because they have met a solid match, Barreto lepowfoot.com and director of The Smell and Taste Center at the University of and Huang said. 713.790.0530 713.951.5000 Texas Medical Center Downtown 8 tmc » p u l s e | f e b r u a r y 2 01 9
Barreto even found her own romantic partner with a cheek swab. “As the CEO of a dating app, it would be unethical for me to meet someone on the app, but occasion- ally I do market research on other dating apps so I have 20 of them on my phone,” she said. “I opened one of the dating apps and I had a message from a lovely man, but the message was about a month old and it was actually a really sweet mes- sage, but he was a redhead. … I’ve never dated a redhead. I like dark features, or so I thought.” The two ended up going on a date and hitting it off, at which point, Barreto asked the redhead if she could swab his cheek to see if they were a match. Barreto and Bin Huang, Ph.D., co-founder and chief technological officer of Pheramor, share a laugh. It turns out they were in the top 10 percentile of compatibility. but it’s in your DNA. I thought I through DNA. They hope to launch the get-go by decreasing the num- “This is why we are changing needed someone with an MBA who it this summer. ber of bad first dates they have to dating by using data,” Barreto said. owned their own company, as well, And to those think Barreto’s go on so they can find compan- “I never thought I wanted a redhead and James is an elementary music work sounds superficial, she has this ionship and be happy. … We are because I thought I didn’t like them, school teacher and we jive so well.” to say: “Instead of working on some- humanizing dating using data. We but I do. I had all of these social con- Barreto and Huang are working thing for a patient who is already are making people give humans a structs in my mind of what I thought on another website for existing in the hospital and super sick, let’s second chance.” I should be looking for in a person, couples to test their compatibility make people’s lives better from Advance your career with the Master of Health Administration Degree from Texas A&M University The Executive Track of the Texas A&M University Master of Health Administration (MHA) Program is tailored for mid-career health professionals ready for their next step. Our 12-course, 48-credit hour master's degree takes 24 months to complete; spans both fundamental and contemporary topics in health administration; and emphasizes the leadership skills and practices required to address the range of issues currently facing health organizations and their leaders. Our MHA Program matches the lifestyle of busy health professionals: Format: Face-to-face class sessions meet one weekend each month Convenience: Courses are taught at the Texas Medical Center in Houston Focus: One 4-credit hour course at a time Expertise: Learn from nationally recognized faculty For more information: https://sph.tamhsc.edu/degrees/mha/emha/ (979) 436-9483 MHA_info@tamhsc.edu tmc » p u l s e | f e b r u a r y 2 01 9 9
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Spotlight Cardiothoracic surgeon. Serial entrepreneur. Inventor. All of these titles apply to TODD ROSENGART, M.D. In 1997, he was part of the team that performed the world’s first viral-based cardiac gene transfer procedure. Later, Rosengart co-founded Vitals.com, a website that allows patients to find and rate doctors, and then XyloCor Therapeutics, a startup that aims to use cardiac gene therapy to treat patients with end-stage coronary artery disease. A professor and chair of the Michael E. DeBakey Department of Surgery at Baylor College of Medicine and a professor of heart and vascular disease at the Texas Heart Institute, Rosengart also holds 12 United States patents. Q | What motivates you to create? Q | Is this why you chose to become a Q | How did your interest in fixing things A | I’m definitely a ‘let’s fix it’ type of person heart specialist? lead to entrepreneurship? and I want to make a difference. The work that A | Subconsciously, because he died of heart A | Operating is phenomenal, but being able to I do on behalf of the department or the college— disease, I thought I was going to be a cardiolo- do something that helps many, many people with from fixing someone’s heart or helping other gist. I’m a big believer in serendipity. My mentor the same effort is really cool, too. When I was at surgeons—is very important. at Northwestern was the chief of cardiology— Northwestern, one day I got a phone call—this is Michael Lesch, M.D., who co-discovered Lesch- before Facebook and before cell phones—from an Q | Why do you think you became a Nyhan syndrome [juvenile gout]—and he said: uncle who needed a cardiologist. I gave my uncle medical problem solver? ‘You’re going to be a great cardiologist. I want you a name and I thought: ‘This is so crazy. If my uncle A | My dad passed away doing exercises when to spend the summer at NYU.’ It was all a mistake had not called me, he would not have had access I was 16—from a heart attack. I came home from because I did this as a second-year student and, to good information about a good doctor. Why high school one day and there were ambulances typically, you don’t do a clerkship until you’re a is this?’ I helped start this company called in front of my house on Long Island. This is 1976. third-year student. It took about a month before Vitals.com. We created this website that had infor- Bypass surgery is still relatively new. Even though they figured out that I didn’t belong there, at mation on physicians all over the country to bet- my dad was a recently educated physician, an which point I’d really become a member of the ter communicate with people. It’s very frustrating obstetrician, the news had not gotten to him— team. By the end of the summer, I said: ‘I love when people are forced to make decisions without or at least in a way he understood—that he prob- these surgeons. They’re so cool. They do great information that should be readily available to ably could have had surgery and be alive today. things.’ I went back to Northwestern and told them. So many bad things happen because we Somehow, that was a disconnect. Subliminally, Dr. Lesch I was going to be a heart surgeon don’t communicate well. It’s been a very signifi- that concept of making sure people are well- rather than a cardiologist. I ended up going to cant element of what I’ve tried to do, though I’m informed has been very important to me. NYU and starting my career there. not really involved in Vitals anymore. ➟ tmc » p u l s e | f e b r u a r y 2 01 9 11
Q | How did you decide to focus your a little bit of temerity to go beyond where you I think we are at an inflec- website on the patient perspective? should be and persevere to do it. If you feel like tion point on how we take A | When we were doing Vitals, my partner— you’re doing the right thing and you’ve done your care of each other and how who is a business guy—said we were going to homework, don’t be shy about persevering on it. get the patient perspective. I said: ‘The patients We are now ready to start a new trial here in the we take care of our patients. don’t understand; we need the doctors’ perspec- Texas Medical Center—same work, taking it to the Between artificial intelligence tive.’ I allowed my partner to convince me I was next level 20 years later. and genetic engineering, I wrong and it turns out the patient perspective, in think we are going to live many ways, was more valuable than the doctors’ Q | What’s the advantage to the body perspective and that’s the way we ended up doing growing its own bypasses? decades longer. I think we are it. At its peak, Vitals.com was getting about 15 mil- A | For some patients who have advanced dis- going to live healthier. I think lion visitors a month. The value was the patient ease, typically because they are diabetics, there is we’re going to look back on perspective. We were early to the online reviews. nothing we can offer them [to restore blood flow to the heart]. They are literally incapacitated with how we take care of patients Q | Can you describe your work with gene angina or chest pain. And when we do bypass or in 10 years and say: ‘What therapy and heart disease? angioplasty, often we can’t revascularize or get were we thinking?’ A | I was a junior faculty member at Cornell good blood flow to the whole heart. We know [New York-Presbyterian Hospital and Weill statistically that patients who don’t get adequate Cornell Medical Center] and we were doing this blood flow to the entire heart won’t do as well. work with gene therapy and having the heart grow This gene therapy can be used as an adjunct to its own bypasses. We had no business thinking standard therapies like bypass or angioplasties. about injecting a virus into the human heart or About two years ago, I was at a Texas Heart doing cardiac gene therapy. No one had ever done Institute transplant review board and these it before. But we said: ‘Why not?’ We were the first patients had such incapacitating angina that they ones ever to treat someone with gene therapy for were candidates for heart transplants. They were heart disease. I was 38 at the time. It’s something going to take this poor person’s heart out with I talk to my residents and students and junior perfectly good function. This is an alternative. faculty about. Believe in what you’re doing; have Aging together is a gift. Couples who call Belmont Village home celebrate every day in a luxurious setting alive with engaging activities, spirited friendships and award-winning wellness programs. Our licensure ensures that couples can continue to live together, even with differing care needs. Together. Like always. Distinctive Residential Settings | Chef-Prepared Dining and Bistro | Pool Premier Health and Wellness Programs | Award-Winning Memory Care Professionally Supervised Therapy and Rehabilitation Services “We haven't missed our house The Community Built for Life.® or car since we got here!” belmontvillage.com HUNTERS CREEK | 713-781-1505 - Voices of Belmont Village WEST UNIVERSITY | 713-592-9200 © 2019 Belmont Village, L.P. | ALF 106016, 030197 12 tmc » p u l s e | f e b r u a r y 2 01 9 HC_WU_TMCPulse_CouplesAlt_GPTW_2_2019.indd 1 1/3/19 2:16 PM
Q | What’s the latest on XyloCor? tremendously rich time with my wife, Debbie. We A | In a couple of months, we will be treating golf together. We have two dogs that we love and patients with end-stage coronary disease. that we walk. Truly, my comfort zone is work, but we travel and see friends and family. Q | Is the clinical trial for patients to grow their own bypasses ready to go? Q | You turned 59 in January and have A | Yes. We are finalizing approvals. We have a trim physique. What is your personal FDA approval. We have independent review board health regimen? approval. We are hoping to do our first patient A | I was never a big believer in training until I here at Baylor St. Luke’s before the summer. started doing it. Now I realize: How could you not? I do an hour in the gym two or three times a week Q | You lead hundreds of people at Baylor. and eat well. My dad died of a heart attack, so I How do you approach running one of the am careful on that. One of my other hats is that nation’s largest surgery departments? I am president of the Society of Surgical Chairs. A | We have 150 faculty, 130 trainees and staff. We have a major national initiative to ensure the What I love about being the chairman of the well-being of physicians as we get older in terms department with so many wonderful people is of our cognitive function. We are actually going to that everyone becomes a force multiplier. To try to launch a national campaign to teach physi- Believe in what you’re help everyone become successful really brings cians how to take care of our cognitive aging. The doing; have a little bit of me joy. I give out the book Team of Teams by physician workforce is growing older and there is temerity to go beyond where General Stanley McChrystal all the time. I love a shortage of physicians. We want to make sure what he said: He is an enabler. He is there to make we train those physicians in their cognitive health you should be and persevere it possible for everyone else to do what is within when they are 50 or 60 so that they can continue to do it. If you feel like you’re their ability as a servant-leader. It’s the first book to contribute. I also play backgammon to take care doing the right thing and I underlined in 30 years. He talks about empow- of my mind. ering people, disseminating information, giving you’ve done your homework, everyone a voice and giving people the ability Q | What’s on the medical horizon that don’t be shy about persever- to get done what they want to get done. What I excites you? ing on it. love about the TMC—and it’s the first thing I talk A | I think we are at an inflection point on how about when we are trying to recruit someone— we take care of each other and how we take care is that everyone supports each other here. If Jim of our patients. Between artificial intelligence Allison wins the Nobel Prize at MD Anderson, I and genetic engineering, I think we are going to am proud of that. That’s rare. You don’t see that in live decades longer. I think we are going to live New York and Chicago. It’s a zero-sum game in healthier. I think we’re going to look back on how many places, unfortunately. we take care of patients in 10 years and say: ‘What were we thinking?’ It’s just very primitive. I think Q | Was there any moment that crystallized artificial intelligence will play a major role in diag- your view of Houston? nosis and picking treatments. We now have com- A | I had not experienced anything like puters that can give us an early warning of sepsis Hurricane Harvey. I did not fully appreciate what that is completely changing the mortality risk happens. When I heard over that weekend that of critically ill patients. That is very simple and the department and everyone else had already yet it’s been a game changer. I think in the next established ‘go’ teams, I said: ‘What?’ People five years we will expand that to 80 or 90 percent took it upon themselves to say: ‘I am here for the of diagnoses and treatment. It’s both scary and duration.’ They did it without being asked and wonderful, which means the role of the physician they did it without being expected to be thanked is going to change dramatically. It is impossible or recognized, which is amazing to me. In the next for physicians now to really keep up with all the thought, I said: ‘Well, of course. That’s what this guidelines in evidence-based medicine and the place is all about.’ That’s what you have to love computers are going to do that. But, just like the about Houston and the Texas Medical Center. pilot monitoring autopilot’s takeoff and landing, We’ve recruited 120 faculty and that sense of we’re going to be there to make sure that it all collaboration and collegiality comes through. fits and that our patients, as human beings, are comforted and supported and helped in the Q | November marked six years since you decision-making—which a computer is never arrived in Houston. You’re an empty nester. going to be able to do. What do you do for fun or outside of your Todd Rosengart, M.D., was interviewed by Pulse assistant various professional pursuits? editor Cindy George. The interview has been edited for A | My son, Eric, is 25. He is in New York—in real clarity and length. estate. Michael is 27 and he’s a clerk for a fed- eral district court judge in Tampa, Florida. It’s a tmc » p u l s e | f e b r u a r y 2 01 9 13
New HQ for TMC Police The station will be located in the heart of the campus B y R ya n H o l e y w e l l The new TMC Police station sits at the corner of Bertner Avenue and Holcombe Boulevard. T he Texas Medical Center Police will relocate to a new, centrally located headquarters this spring in order to better serve the growing “It was important to us to have a police station located in the heart of our campus,” said TMC President and CEO William “Bill” McKeon. “This during emergencies. The project also includes improvements that make Bertner Avenue—which passes under a TMC community. facility will allow our police and security officers garage—more inviting to pedestrians. The side The new facility, located at the corner of to continue serving the hundreds of thousands of of the police station is outfitted with LED lights, Bertner Avenue and Holcombe Boulevard, brings people who visit our campus every day.” and additional lighting is planned for the ceiling the TMC Police into the core of the medical The move coincides with TMC’s continued above the sidewalk. A right-hand turning lane center. The department was previously headquar- investment in strengthening the police depart- was removed from Bertner Avenue, allowing for tered about a mile ment to provide a an expansion of the pedestrian area outside the away at TMC’s Hermann Park more secure campus. police station. John P. McGovern UN IVE The station includes “This is a major corridor, not just for automo- R SI campus, near the T YB LV D Houston briefing and training bile traffic, but for pedestrians and bicyclists, as . Zoo Brays Bayou eastern edge of rooms, modern dis- well,” McKeon said. “These changes will make the the medical center. patch equipment and 288 street safer and more comfortable for everyone . ST . ST The new head- space for police and who uses it.” N IN AI NN M quarters is located Texas Medical Center security officers to FA Police Headquarters in a renovated write reports. Backup space that was HOLCOMBE BLVD. generators will V E. The Texas Medical Center Police can be reached BERTNE R A previously used as allow the station to ST. at 713-795-0000. a parking office. continue to function GE RID R D. . VD GR BL MB E DA EE D SW O O CA N S. BRAE ALM BR IA R DR . IL TRA ISH SPAN OLD 14 t m c » p u l s e | f e b r u a r y 2 01 9
Trending topics in health, science and medicine By Shanley Pierce E-CIGARETTES ASK THE EXPERTS: PREDICTIONS FOR 2019 REGENERATIVE AND YOUTH MEDICINE “The FDA is focused on regu- “Biologics are no lation. The CDC is focused on longer new tech- surveillance. NIH and NIDA nologies. Both GYNECOLOGIC ONCOLOGY (National Institute on Drug cell therapies “We are at the forefront of incorporating immunotherapy into our treat- Abuse) are focused on more and scaffold ment portfolio and have recently launched a broad range of research. But the reality is, technology are cutting-edge clinical trials in many gynecological cancers. we can’t solve this problem, now established In addition, there will be an increasing focus on personal- this crisis, this epidemic from as effective therapeutic tools. In ized treatments. Genetic testing for ovarian and endome- Washington, D.C. We need states 2019, multiple consortia com- trial cancer patients is key, as there are new drugs that are who control a lot of the retail envi- prised of industry, not-for-profit particularly effective in women with inherited mutations.” ronment to look at the policies, organizations and academia are the parents and teachers who actively engaged in, and com- — KAREN LU, M.D. see use on a day-to-day basis to Professor and Chair in the Department of Gynecologic Oncology and Reproductive mitted to, solving the greatest become aware of these products Medicine at The University of Texas MD Anderson Cancer Center needs to enable manufacturing of and to understand organs and tissues—illustrating the steps they that the field has come of age and can take to is worth the investment.” help us turn around this POPULATION HEALTH — DORIS TAYLOR, PH.D. HEALTH POLICY epidemic.” Director of Regenerative Medicine “In health care, I expect the polit- “This is an Research at Texas Heart Institute ical debate will go in one of two exciting time in — JEROME ADAMS, M.D. terms of both directions. One direction will be U.S. Surgeon General unprecedented around modifications, expansions TECHNOLOGY and improvements in Medicare vaccine access “Operations performed in the as a vehicle for ensuring access to and the introduc- abdomen, pelvis, chest, cardiovas- GENETICS health care and with a particular tion of new vaccines. cular and neurological systems “Genomic technologies, like recipe for handling costs. … The Unfortunately, opposing these will continue to become more gene editing and low-cost DNA second touchstone is around the exciting trends is a growing and targeted with the expanded sequencing, will continue to Affordable Care Act, its promise ominous anti-vaccine movement, use of ever more sophisticated transform the fields of human and potentially its now well established in North intraoperative image guidance genetics and medicine. In the new substitution. The America and Europe, but working and pre-procedural planning with year, we will see continued exam- ACA is still its way into … Africa, Asia and enhanced functional and struc- ples of clinical successes of gene functioning, Latin America. … The anti-vaccine tural imaging platforms, from CT therapy and gene editing in the but it’s going to movement successfully blocked to MRI to PET. Gloved surgeons’ treatment of somatic tissues or undergo some vaccination programs for measles, hands will increasingly rarely feel organs, especially in rare genetic challenges.” influenza, and other childhood the warmth of the patient’s body diseases and cancer. In contrast, vaccines, as well as the introduc- as technologies and the scientific and ethical opposi- — STEPHEN LINDER, PH.D. tion of new HPV vaccines for cer- devices … fill tion to germline gene editing will Associate Director of the vical cancer, so we must continue the interface raise society’s awareness to guard Texas Medical Center our efforts to debunk vaccine between the against rogue exper- Health Policy Institute myths in the years to come.” surgeon and iments while also supporting con- patient’s body.” — PETER HOTEZ, M.D., PH.D. tinued thought- Dean of the National School — BARBARA BASS, M.D. ful debate on of Tropical Medicine at Executive Director of the Houston this topic.” Baylor College of Medicine and Methodist Institute for Technology, Director of the Texas Children’s Innovation & Education (MITIE) — BRENDAN LEE, M.D., PH.D. Center for Vaccine Development Chair of Molecular and Human Genetics at Baylor College of Medicine tmc » p u l s e | f e b r u a r y 2 01 9 15
Chilling at Cool Acres The Brazos River retreat owned by the late Denton A. Cooley, M.D., was home to the annual St. Luke’s family picnic By Britni R. McAshan I n 1958, pioneering cardiovascular surgeon Denton A. Cooley, M.D., purchased a Brazos River retreat for his family that was not too as many friends as we could pile in, and go out to what we would call ‘the farm.’” Located in Orchard, Texas—about 30 miles transplant in the United States—a bold act that famously fractured his relationship with his mentor, Michael E. DeBakey, M.D.—and became far from their Houston home or from Cooley’s south of Houston—the 406-acre compound the first heart surgeon to implant a total artificial patients in the burgeoning Texas Medical Center. spreads across nearly one mile of riverfront heart in a human. He christened the ranch Cool Acres. property. The ranch sits on a bluff 115 feet above He was 96 when he died in 2016. And today, “My father worked seven days a week,” said the Brazos River and includes five homes built Cool Acres is for sale, with an asking price of Susan Cooley, Ph.D., a nurse and former profes- between 1960 and 1982. In addition to a pond $7.3 million. sor at The University of Texas Health Science named Lake Louise—after the surgeon’s wife— For decades, though, Cool Acres was more than Center at Houston, who is one of the physician’s the property holds two tennis courts, a pool, a a place for the Cooley family to play and relax. five daughters. “He worked Saturdays until 2 p.m. roller skating rink and party pavilion, stables The property also served as the site of the annual and then had to be back on Sunday afternoon. for horses and even Orchard’s original post St. Luke’s family picnic for many years. Starting He would come home after Grand Rounds on office building. in 1960, Cooley and his family welcomed staff Saturday, honk the horn and we would all jump Denton A. Cooley was a busy heart surgeon from what was then St. Luke’s Episcopal Hospital. in the car with my mother, the fried chicken and who performed the first successful human heart Doctors, surgeons, nurses, residents and their 16 t m c » p u l s e | f e b r u a r y 2 01 9
Far left: House No. 4 at Cool Acres appeared in Architectural Digest. Top row, this page: Denton A. Cooley, M.D., left, with O.H. “Bud” Frazier, M.D., center; James “Red” Duke Jr., M.D., with his first wife, Betty. Bottom row, this page: The original Orchard, Texas, post office sits on Cool Acres; The swimming pool on the property was built by one of Cooley’s patients. families all dropped by. kind of a tradition to go out there,” Todd Frazier Susan Cooley said her parents stopped host- “It was always a funny cast of characters, but recalled. “Those are some of my earliest memories ing the picnic when her dad reached his eighties; there would be volleyball games, softball games, of playing baseball and skeet shooting. It was fun her mother also died in 2016, at the age of 92. barbecue and fireworks—just an afternoon of because the health care professionals from St. But relatives have continued to enjoy Cool everybody relaxing, drinking beer and Cokes and Luke’s who were from all over the world and had Acres for everything from weddings to holiday just having fun,” Susan Cooley said. “Dad always never experienced the Texas countryside could all gatherings. Between the five houses on the thought that people who worked together ought come together.” property—pragmatically referred to as House to know each other personally and play together.” Every year at the picnic, Denton and Louise No. 1, House No. 2, House No. 3, House No. 4 and Guests at the annual picnic included Texas Cooley took all the children on a hayride. the pool house—there are 18 bedrooms, 10 full Heart Institute surgeon O.H. “Bud” Frazier, M.D., “It was an older, historic fire truck and they bathrooms and three half bathrooms. ➟ who trained as a resident under Cooley. would do a hayride at night when all of the fire- Frazier’s son, Todd, who directs the Center for flies were coming out,” Frazier said. “It was just Performing Arts Medicine at Houston Methodist really informal and relaxing and I think he just Hospital, remembers the picnic well. wanted to make everyone feel welcome and show “I went every year when I was a kid; it was them a good time.” tmc » p u l s e | f e b r u a r y 2 01 9 17
My father worked seven days a week. He worked Saturdays until 2 p.m. and then had to be back on Sunday afternoon. He would come home after Grand Rounds on Saturday, honk the horn and we would all jump in the car with my mother, the fried chicken and as many friends as we could pile in, and go out to what we would call ‘the farm.’ — SUSAN COOLEY, PH.D. Daughter of Denton A. Cooley, M.D. Each structure differs vastly in architectural photographs of Cooley family members with style and interior aesthetics, but all were designed everyone from trauma surgeon James “Red” Duke by Denton A. Cooley. Many of the furnishings of Jr., M.D., the founder of Memorial Hermann Life House No. 4 are originally from the historic Hotel Flight, to Princess Anne, the British royal and only Galvez in Galveston, one of the surgeon’s many daughter of Queen Elizabeth II. business ventures. That house was also featured “Going through their stuff, there are so many Cooley prepares to pitch at the annual picnic’s in Architectural Digest. A former patient was so questions,” Susan Cooley said. “You know, why softball game. (All picnic photos courtesy of inspired by the home, he painted a rendering were we in Italy with Bing Crosby? Why were we Susan Cooley.) for Cooley. visiting the Pope at his summer palace?” “He was a very famous Russian artist and he Her eldest sister, Mary Cooley Craddock, More than two years after the passing of their wanted to paint a picture of the ranch, so he came explained why the family was in Italy that parents, the sisters are eager for another family to out, drew it and then took it back to Russia,” Susan summer. make memories at Cool Acres. Cooley said. “He shipped back this painting of “A very generous patient from Florence “My parents were always here,” Susan Cooley Cool Acres in the snow. It doesn’t snow out here, arranged the whole thing because Dad really said. “I don’t even know what it’s like being here but we still kept it.” wanted to get the Pope’s blessing about the without them.” At the moment, each of the homes on the heart transplant,” Craddock said. “He did property is filled with letters, mementos and give Dad his blessing.” 18 tmc » p u l s e | f e b r u a r y 2 01 9
New technology and techniques By Shanley Pierce Mending a hole in the heart B efore birth, babies rely on their mothers for oxygen. A mother’s oxygen-rich blood travels from the right atrium to the left atrium of a baby’s developing heart through a small, open flap called the foramen ovale. All babies are born with this tiny hole in their hearts, but in most cases the hole closes within six months. For a quarter of the population, though, the hole never closes, a condition known as patent foramen ovale (PFO). This opens the door for recurring strokes. Enter Richard Smalling, M.D., director of interventional cardiology with McGovern Medical School at UTHealth and the Memorial Hermann Heart & Vascular Institute-Texas Medical Center. Smalling led an eight-year nationwide clinical trial to study the safety and efficacy of the Amplatzer PFO Occluder, a device that can patch up this congenital heart defect in less than an hour. The trial ended in late 2011 and follow-up data from nearly six years later shows the device reduces the risk of recurrent stroke by 45 to 62 percent. “The beauty of it is: It’s delivered via a catheter that we insert through a vein in the leg,” Smalling explained. The PFO Occluder is outfitted with two discs made of woven nickel titanium mesh, one the size of a nickel and the other the size of a quarter. Before the device is inserted in the catheter, it is stretched to assume the shape of the tube. Once the catheter enters the left atrium through the hole in the heart, the smaller mesh disc expands and tugs against the wall between the heart’s two upper chambers to col- lapse the flap. The second, larger disc springs open as the catheter is retracted in the right atrium. With the flap securely sandwiched between both discs, heart tissue heals over the device within six months, creating a new wall between the two upper chambers of the heart. According to Smalling, the device, which has been approved by the U.S. Food and Drug Administration, provides a simple, yet elegant, solution for many patients. “With the device, we can at least eliminate one cause of recurrent stroke,” he said. tmc » p u l s e | f e b r u a r y 2 01 9 19
John Barnes confronted the shooter at Santa Fe High School By Alexandra Becker O N the morning of May 18, 2018, Officer John a fire alarm pierced the hallway and a rush of students Barnes arrived at work hungry. It was the Friday of poured out of the gymnasium. Gun by his side, he pushed National Police Week, and Santa Fe High School through the crowd, craning his neck as he listened for had planned an omelet breakfast for its school resource gunshots and scanning every square inch of his sight line officers—a gesture of thanks and appreciation for keeping for someone with a weapon. students and faculty safe throughout the year. Then, he said, it all went to hell. Barnes can remember the omelets, that they were sup- “People are getting shot in front of me,” Barnes posed to be served that morning. But his memory grows recalled. “And very quickly, everybody either exits out foggy when he tries to recall why he first stepped into the the door or goes past me.” hallway, where a woman approached him to report sounds Barnes was left standing in the hallway, blood smeared of gunfire. Just one month earlier, Santa Fe High, located on the ground in front of him and glass shattering behind about 36 miles southeast of Houston, had ordered a lock- him. Another Santa Fe Independent School District (ISD) down after rumors of an active shooter circulated; Barnes officer, Gary Forward, was close behind. Could there be assumed that this morning’s report, too, would turn out to more than one shooter? One behind and one in front? be a misunderstanding. Never, not once, did Barnes think his confusion would be But then the sting of gunpowder hit his nostrils. The explained away by the wide spray of small metallic spheres smell was unmistakable. from the shell of a shotgun, a weapon worshiped by hunt- Barnes quickly removed his pistol from his belt as ers for its deference to destruction above precision. ➟
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Credit: Steve Gonzales/Houston Chronicle via AP Law enforcement responds to Santa Fe High School on May 18, 2018, after an active shooter was reported on campus. Barnes barked into his radio, then focused his attention an addition Barnes had initially dismissed as frivolous. down the hallway. Slowly, carefully, and with his gun drawn, “It was like somebody stuck a hose in it and it was just he slid his body along the left side of the wall, using draining out,” Barnes would later say of his wound. He it, and the corner, as a shield. He was going to can remember looking down at the large hole in sneak up on the shooter. With his pistol out his arm and feeling sick. front, he hugged the corner of the wall and The two officers kept their eyes fixed on drew himself out. the hallway, waiting for the shooter to swing The assailant—Dimitrios Pagourtzis, at back around the corner at any second. Barnes the time a 17-year-old student, is accused of the kept telling Forward to leave; the thought of shooting rampage at the school—was standing a colleague taking a bullet while tending to his there with his father’s shotgun, waiting. The teen- arm was unbearable. ager allegedly pulled the trigger as soon as he saw the But Forward refused, and once the tourniquet was officer’s right arm. secure, he held open the door to a nearby dance classroom Only 60 seconds had passed since Barnes first stepped so that Barnes could crawl inside. Then Forward left— out of his office. back to the hallway, to the corner and to the shooter. Soon, a group of officers found Barnes and helped him to his ** feet. He only made it about 10 yards before collapsing to the ground. Shotguns are not loaded with the same slick, ogival- “Drag me, just drag me, just drag me,” he remembers nosed bullets found inside handguns or assault rifles. pleading. With the threat of the shooter looming, one of Instead, they use shells packed with tiny metallic projec- the officers, unthinking, grabbed Barnes’ right arm. Pain tiles known as shot. Once fired, the shot sprays the target, stunned his whole body. creating multiple entry points; if a shooter’s aim is off, he or Ultimately, Barnes was dragged out of Santa Fe High she may still hit a target’s periphery. by his duty belt, leaving a trail of blood behind him. Every shotgun shell holds a certain number of pellets. Paramedics lifted him onto a stretcher as close friend and In Barnes’ case, at least three pellets tore through his right fellow Santa Fe ISD officer Elizabeth “Cibby” Moore rushed arm, shredding his brachial artery, a main thoroughfare to to his side. They could still hear the roar of gunfire inside the heart. Barnes, a husband and father of two, would have the school. bled to death within minutes had it not been for Officer Barnes felt faint, his head somehow both airy and Forward, who pulled a tourniquet from his vest and swiftly weighted, like he was floating under a lead blanket. His wrapped it around his friend’s arm. The team had only blood was everywhere but inside his body. Amid his haze, begun to carry the military-grade devices a month earlier, he could make out that he was riding in an ambulance. 22 t m c » p u l s e | f e b r u a r y 2 01 9
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