Prescription Opioids and Heroin Epidemic in Georgia

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Prescription Opioids and Heroin Epidemic in Georgia
Prescription Opioids                    SARA Executive Committee
                       Jim Langford – Chair, SARA; Executive Director,
and Heroin Epidemic    Georgia Prevention Project

in Georgia             Dr. Amanda Abraham – Assistant Professor, School of
                       Public and International Affairs, University of Georgia
- A White Paper        Dr. Aaron Johnson – Associate Professor, Institute of
                       Public and Preventive Health, Augusta University

                       Dr. Merrill Norton – Clinical Associate Professor,
                       College of Pharmacy, University of Georgia

                       Dr. Glenda Wrenn – Associate Professor, Director
                       of Behavioral Health, Satcher Health Leadership
                       Institute, Director, Kennedy Center for Mental Health
                       Policy, Morehouse School of Medicine
2017
                               ©2016 Georgia Prevention Project - All Rights Reserved.
Prescription Opioids and Heroin Epidemic in Georgia
TABLE OF
Prescription Opioids and Heroin Epidemic in Georgia                                             CONTENTS

 Contents
 Prescription Opioids and Heroin Epidemic in Georgia

 Executive Summary

 Findings and Policy
 Recommendations
 I. Opioids overview                             III. Proposed legislative agenda
   1. What opioids are                                for Georgia
   2. How opioids affect the human body            1. Increase access to Naloxone

   3. The U.S. opioid epidemic                     2. Improve access to opioid use disorder
                                                      treatment, including medication assisted
   4. Relationship between nonmedical use of          treatment (MAT and recovery support
      prescription opioids and heroin use             services)
   5. Impact of opioid use                         3. Increase state funding for substance abuse
     a. Overdose deaths in Georgia                    prevention education

     b. How Georgia compares to other states       4. Increase funding and improve
        and the nation                                mechanisms for addressing neonatal
                                                      abstinence syndrome (NAS)
   6. Economic costs of opioid misuse and
      abuse in Georgia and the United states       5. Strengthen the Prescription Drug
                                                      Monitoring Program (PDMP)
                                                   6. Increase oversight of pain clinics
 II. Key Georgia issues
                                                   7. Create standards for physician education
   1. Overdose reversal
                                                   8. Create a “blue ribbon” commission on
   2. Medication assisted treatment & recovery        substance use recovery supports and
      support services                                recovery-oriented systems of care
   3. Prevention education
   4. Neonatal abstinence syndrome               IV. Appendix
   5. Controlling access to opioids              V. Resources
     a. Prescription Drug Monitoring Program
     b. Pain clinics
     c. Prescriber education

                                                  ©2016 Georgia Prevention Project - All Rights Reserved.   2
Prescription Opioids and Heroin Epidemic in Georgia
EXECUTIVE
Prescription Opioids and Heroin Epidemic in Georgia                                                        SUMMARY

 Introduction
 Substance Abuse Research Alliance (SARA) is a program of the Georgia Prevention Project, and it
 initiated this study in April of 2016 as the organization’s first collaborative project with a primary goal to
 assist the Georgia State Senate Study Committee on Opioids and Heroin in its work.
 With more than 60 participants, SARA includes researchers and practitioners with a wide spectrum of
 experience in substance misuse work. SARA participants represent the following organizations:

   •   Applied Research Services, Inc.                      • Georgia State University – multiple
   •   Augusta University                                     departments and programs
   •   Carter Center Mental Health Program                  • Lab Solutions, Inc.
   •   Centers for Disease Control and Prevention           • Mercer School of Medicine
   •   Emory University – multiple departments              • Morehouse School of Medicine – multiple
       and programs                                           departments and programs
   •   Georgia Council on Substance Abuse                   • Parkaire Consultants, Inc.
   •   Georgia Department of Behavioral Health              • Partnership for Drug-Free Kids
       and Developmental Disabilities (DBHDD)               • Skyland Trail
   •   Georgia Department of Public Health (DPH)            • The Council on Alcohol and Drugs
   •   Georgia Prevention Project                           • University of Georgia – multiple departments
   •   Georgia Southern University                            and programs

 SARA believes that opioid and heroin
 use in Georgia seriously threatens the         What you need to know now
 health, prosperity and general well-
 being of Georgians throughout the              The U.S.
 state, across almost all sectors of life       200 percent prescription opioid overdose (OD) deaths
 and work.                                                  increase since 2000
 Like Georgia, several other states struggle    125 million Americans who reported misusing
                                                            prescription pain relievers in the past year
 over how to ameliorate the suffering and
 death rates associated with prescription       80 percent of heroin users reported using
 opioids and heroin, how to prevent                         prescription opioids for non-medical
                                                            reasons before beginning to use heroin
 citizens from misusing these substances,
 and how to intervene effectively to treat
                                                Georgia
 opioid use disorder and promote long-
 term recovery.                                 549 opioid drug ODs in 2015
                                                29 counties where drug OD rates outpace U.S. average
 SARA stands ready to assist the Georgia
 Legislature and the State Senate Study         11   Georgia ranks among top 11 states with most
                                                     prescription opioid OD deaths
 Committee in any way that we can.

                                                             ©2016 Georgia Prevention Project - All Rights Reserved.   3
Prescription Opioids and Heroin Epidemic in Georgia
EXECUTIVE
Prescription Opioids and Heroin Epidemic in Georgia                                                  SUMMARY

 Executive Summary
 Georgia’s prescription opioid and heroin            opioid receptors, most prominently the Mu (μ)
 problem threatens the well-being of every           receptors. Mu receptors account for most of
 Georgian at every socio-economic level and in       the effects of opioids and are primarily located
 every geographic region of the state.               in the brain, spinal cord, peripheral nervous
                                                     system, and intestinal tract.
 This study by the Substance Abuse Research
 Alliance (SARA) seeks to educate public             By stimulating the Mu receptors, opioids
 officials and the general public about the opioid   reduce the perception of pain by slowing
 epidemic that is devastating communities            down and blocking pain signal transmission
 across the country and here in Georgia. We          to the brain while also triggering the release
 answer key questions and also offer a proposed      of dopamine, a neurotransmitter used in
 legislative agenda to consider as Georgia           the brain’s pleasure or reward system. When
 legislators move to address this pervasive and      activated, dopamine produces a pleasurable
 growing challenge in our lives and communities.     and often euphoric feeling.
 What Are Opioids? How Do They                       Use of opioids for more than a short period
 Affect The Human Body?                              of time leads to tolerance and physical and
                                                     psychological dependence. This means opioid
 Opioids are a class of drugs that act on the        users must take larger doses of opioids over
 body’s opioid receptors including natural,          time to achieve the same effect. Additionally,
 semi-synthetic and synthetic opioids. Natural       opioid users must not stop taking these drugs
 opioids include drugs such as morphine, which       abruptly, or they will experience withdrawal
 are derived from the resin of the opium poppy,      symptoms such as agitation, anxiety, muscle
 semi-synthetic opioids such as hydrocodone          and bone pain, insomnia, vomiting or diarrhea.
 and oxycodone, and synthetic opioids such as        Withdrawal symptoms occur when the amount
 fentanyl and methadone.                             of opioids used decreases or stops.
 Opioids are often used medically to relieve
 moderate to severe pain, but can also be used
                                                     How Did We Get To A U.S.
 for other conditions -- for example, to suppress    Opioid Epidemic?
 cough, to treat diarrhea and even to treat          Opioid overdoses - including prescription opioids
 opioid use disorder. Opioids are very effective     and heroin - kill 78 people daily. This number has
 for treating severe pain such as that associated    quadrupled since 1999. In 2015 alone, opioids
 with cancer, post-surgery, or accident-related      were involved in over 28,470 deaths.
 injuries. While opioids provide pain relief, they
                                                     Despite the staggering statistic, the number
 also cause physical dependence, respiratory
                                                     of prescriptions written for opioid analgesics
 depression, euphoria, reduced intestinal motility
                                                     continues to increase.
 and other desired and undesired effects. Since
 these pharmacologic effects focus on blocking       Misuse of prescription opioids, and heroin use,
 pain, opioids have high potential for misuse.       are also on the rise. In 2015, approximately
                                                     12.5 million Americans reported misusing pain
 Opioid drugs mimic the body’s natural
                                                     relievers in the previous year and approximately
 response to pain by stimulating the body’s
                                                     914,000 Americans reported use of heroin.

                                                       ©2016 Georgia Prevention Project - All Rights Reserved.   4
Prescription Opioids and Heroin Epidemic in Georgia
EXECUTIVE
Prescription Opioids and Heroin Epidemic in Georgia                                                  SUMMARY

 And, the costs of this epidemic of prescription     prescribing of prescription opioids (e.g., PDMPs)
 opioid overdose and misuse are high, estimated      may be a driver of increased deaths from heroin
 at $78.5 billion in 2013 alone.                     overdose, there is little empirical evidence of a
                                                     causal link.
 Who Is At Greatest Risk?
                                                     Instead, the evidence suggests that market
 The highest rates of prescription opioid
                                                     forces such as increased availability, reduced
 overdose deaths from 1999 to 2014 were
                                                     price and increased purity of heroin could be
 among non-Hispanic whites and American
                                                     more important drivers of increased heroin use
 Indian or Alaskan Natives, persons aged 25 to
                                                     and heroin overdose deaths.
 54, and men. Rates of prescription overdose
 deaths are on the rise for women (Centers for       What Is The Impact Of Opioid Use
 Disease Control, CDC, 2016). Risk factors for       In Georgia?
 prescription opioid misuse and overdose include
 doctor shopping (i.e., receiving overlapping        Similar to national trends, deaths related to
 prescriptions from multiple providers and           opioid overdose continue to rise in Georgia.
 pharmacies), taking high daily doses of             Recent data from the Georgia Department of
 prescription pain relieves, having mental illness   Public Health indicate that deaths related to
 or a history of substance misuse, being low-        drug overdose are now almost equal to deaths
 income, and living in a rural area (CDC, 2016).     due to motor vehicle crashes (Figure 1).

 According to Centers for Disease Control and        Opioids, primarily prescription pain relievers and
 Prevention, people at highest risk for heroin       heroin, are the main driver of drug overdose
 addiction are those addicted to prescription        deaths. Of the 1,307 drug overdose deaths in
 opioid painkillers, cocaine, marijuana and          2015 in Georgia, 900 or 68 percent were due
 alcohol; people 18 to 25 years of age living in     to opioid overdoses including heroin (Figure 2).
 large metropolitan areas, and people without        Further, a statistically significant increase in the
 insurance or enrolled in Medicaid.                  drug overdose death rate occurred from 2013
                                                     to 2014, and overdose deaths tripled between
 What Is The Relationship Between                    1999 and 2013 in Georgia.
 Non-Medical Use Of Prescription                     Prescription opioid overdose deaths in Georgia
 Opioids And Heroin Use?                             increased tenfold to 549 deaths, or a rate of 5.5
 Several descriptive and observational studies       per 100,000 age-adjusted deaths, between 1999
 suggest a link between non-medical use of           and 2014. Georgia: Among top 11 states with
 prescription opioids and heroin, particularly       the most prescription opioid overdose deaths
 among people with frequent nonmedical use or        (Figure 3).
 people with prescription-opioid use disorder.       Recent data indicate that 55 of Georgia’s 159
 Two recent national studies found that about        counties had higher drug overdose rates
 80 percent of heroin users reported using           than the U.S. average in 2014. This marks a
 prescription opioids for non-medical reasons        significant increase from 11 years ago, when just
 before beginning use of heroin. However,            26 Georgia counties exceeded the U.S. average.
 it is important to note that only a small           Sixty percent of the 55 counties with drug
 percentage (less than 5 percent) of people          overdose rates higher than the national average
 who use prescription opioids for non-medical        in 2014 are located in rural areas with limited
 reasons begin using heroin. This small              access to substance use disorder treatment
 percentage translates to several hundred            and/or medication-assisted treatment. These
 thousand new heroin users per year and              numbers suggest that two-thirds of all counties
 should not be minimized.                            in Georgia and 77 percent of rural counties
 While some argue that implementation of             have limited or no access to an evidence-based
 policies to address misuse and inappropriate        practice for opioid use disorder.

                                                       ©2016 Georgia Prevention Project - All Rights Reserved.   5
Prescription Opioids and Heroin Epidemic in Georgia
EXECUTIVE
Prescription Opioids and Heroin Epidemic in Georgia                                                                                                                                              SUMMARY

 Figure 1:
        Deaths Related to Drug Overdose and Motor Vehicle Crashes, Georgia, 2001-2015

                                                                                               1,673
                                                                                1,670
                                                                 1,568
        1,509

                       1,492

                                                   1,482

                                                                                                              1,456
                                     1,387                                                                                                                                                       Source:

                                                                                                                                                                                         1,345
                                                                                                                                                                                        1,307
                                                                                                                                                                               1,274
                                                                                                                           1,253

                                                                                                                                                 1,248
                                                                                                                                      1,223

                                                                                                                                                                      1,223

                                                                                                                                                                              1,219
                                                                                                                                                                                                 Georgia

                                                                                                                                                            1,177

                                                                                                                                                                    1,125
                                                                                                                                              1,070

                                                                                                                                                          1,059
                                                                                                                                   1,074
                                                                                                                                                                                                 Department

                                                                                                                       1,006
                                                                                                        956
                                                                                                                                                                                                 of Public

                                                                                         859
                                                                          767
                                                                                                                                                                                                 Health,
                                             697

                                                           682
                               647
                 611

                                                                                                                                                                                                 Office of
  559

                                                                                                                                                                                                 Health
                                                                                                                                                                                                 Indicators
                                                                                                                                                                                                 for
   2001          2002           2003         2004           2005          2006           2007           2008           2009        2010       2011        2012      2013      2014      2015
                                                                                                                                                                                                 Planning,
                                                                                                         Drug Overdose Deaths                            Motor Vehicle Crash Deaths              Death files.

 Figure 2:
   Number of Drug Overdose Deaths Related to Opioids
   including Heroin in Georgia, 2001-2015                                                                                                                                       1,274
                                                                                                                                                                                         1,307

                                                                                                                                   1,074       1,070       1,059      1,125
                                                                                                                       1,006
                                                                                                         956
                                                                                         859                                                                                             900
                                                                          767                                                                                                   795
                               647           697           682                                                                                                                    Source:
                611                                                                                                                 600         622         633       606
  559                                                                                                                   554                                                       Office of
                                                                                                         467                                                                      Health
                                                                                         380                                                                                      Indicators
                               265           277           294
   243          246                                                       242                                                                                                     for Planning
                                                                                                                                                                      90 121      (OHIP),
   3                                          2             3              1               6             20               16          3         25      31     48
                 1              5                                                                                                                                                 Georgia
                                                                                                                                                                                  Department
 2001           2002           2003          2004          2005          2006            2007           2008           2009         2010       2011    2012   2013 2014      2015
                                                                                                                                                                                  of Public
        All Drug Overdose Deaths                                 Opioid Overdose Deaths, Including Heroin                                          Heroin Overdose Deaths, Only   Health.

 While prescription opioid deaths declined last year, users began shifting from prescription opioids to
 heroin. Hence, the spike in opioid deaths which include heroin.
 Figure 3:
                  Number of Prescription Opioid Overdose Deaths in Georgia, 2001-2015
                                                                                                                                                                                            Source: Centers
                                                                                                                                                                         588
                                                                                                                                                                                   549
                                                                                                                                                                                            for Disease
                                                                                                                                                                                            Control and
                                                                                                                                          498       488
                                                                                                                               464                                                          Prevention
                                                                                                                      448                                      441                          (CDC), National
                                                                                                                                                                                            Center
                                                                                                       362                                                                                  for Health
                                                                                        348
                                                                         308                                                                                                                Statistics.
                                                           270                                                                                                                              Multiple Cause
                                             221                                                                                                                                            of Death
                  171           186                                                                                                                                                         1999-2014 on
   152                                                                                                                                                                                      CDC WONDER
                                                                                                                                                                                            Online
                                                                                                                                                                                            Database. Data

                                                                                                                                                                                       1
                                                                                                                                                                                            are from the
                                                                                                                                                                                            Multiple Cause
                                                                                                                                                                                            of Death Files,
   2001          2002          2003          2004          2005          2006           2007           2008       2009         2010       2011      2012       2013      2014     2015
                                                                                                                                                                                            1999-2015.

                                                                                                                                    ©2016 Georgia Prevention Project - All Rights Reserved.                     6
Prescription Opioids and Heroin Epidemic in Georgia
EXECUTIVE
Prescription Opioids and Heroin Epidemic in Georgia                                                                             SUMMARY

 What Is The Cost Of Opioid Use And                 The Patient Protection and Affordable Care
 Misuse In Georgia And The U.S.?                    Act (ACA) of 2010 provides greater access
                                                    to SUD treatment through major coverage
 The economic burden of prescription opioid         expansions, regulatory changes requiring
 overdose, misuse and disorders in the U.S. is      coverage of SUD treatments in existing
 estimated at $78.5 billion in 2013 with over one   insurance plans, and requirements for SUD
 third of this amount coming from increased         treatments to be offered on par with medical
 health care and substance use treatment            and surgical procedures. The ACA enables
 costs ($28.9 billion). The health care costs       states to address the opioid epidemic through
 associated with opioid misuse in Georgia           four primary mechanisms: insurance coverage
 alone were estimated at $447 million in 2007       expansions, regulatory insurance reforms that
 with estimated per-capita costs at $44. Given      require inclusion of SUD treatments, enhanced
 the increase in overdose deaths and misuse         parity, and opportunities to integrate SUD
 of opioids in Georgia over 11 years, some          treatment and mainstream healthcare.
 estimates indicate that health care costs
 associated with opioid misuse in Georgia have      On July 22, 2016, President Obama signed
 increased by 80 percent since 2007.                the Comprehensive Addiction and Recovery
                                                    Act (CARA). This is the most comprehensive
 Hospitalizations related to opioid use and         effort undertaken by Congress to address the
 misuse in Georgia also have skyrocketed,           opioid epidemic.
 from about 302,000 in 2002 to about 520,000
 in 2012. Similarly the cost of opioid related      While it authorizes over $181 million each year
 inpatient care more than doubled during the        in new funding to fight the opioid epidemic over
 same time period, rising to $15 billion in 2012.   the next 10 years, monies must be distributed
                                                    annually through the regular appropriations
 What Has Congress Done?
                                                    process. CARA establishes a comprehensive,
 Three major pieces of federal legislation          coordinated, and balanced strategy through
 addressed substance use disorders (SUD) in the     enhanced grant programs that would expand
 past decade:                                       prevention and education efforts, while also
   • Mental Health Parity and Equity                promoting treatment and recovery. The bill
     Addictions Act of 2008                         passed the U.S. Senate in March 2016, by a
   • Patient Protection and Affordable              vote of 94-1. The bill passed the U.S. House of
     Care Act of 2010                               Representatives in May 2016, by a vote of 400-5.
   • Comprehensive Addiction and                    CARA Six Pillars of Coordinated Response:
     Recovery Act of 2016.                          Solving the Opioid and Heroin Problem.
 The Mental Health Parity and Equity
 Addictions Act of 2008 requires private group
                                                                         Comprehensive
 health plans with 50 or more employees and
                                                                    Addiction and Recovery Act
 Medicaid managed care plans that cover SUD                                  (CARA)
 treatment do so in a manner that is no more
 restrictive than coverage of other medical and
                                                                                                                                  Overdose Reversal
                                                                                           Law Enforcement

 surgical procedures. Parity requirements have
                                                                                                             Criminal Justice
                                                       Prevention

 not been extended to private plans in state
                                                                    Treatment

                                                                                Recovery

                                                                                                                 Reform

 health insurance exchanges and Medicaid
 expansion plans.

                                                      ©2016 Georgia Prevention Project - All Rights Reserved.                                         7
Prescription Opioids and Heroin Epidemic in Georgia
EXECUTIVE
Prescription Opioids and Heroin Epidemic in Georgia                                                   SUMMARY

    Key Provisions of CARA
     • Expand prevention and educational efforts—particularly aimed at teens, parents and
       other caretakers, and aging populations—to prevent the use of methamphetamines,
       opioids and heroin, and to promote treatment and recovery
     • Expand the availability of naloxone to law enforcement agencies and other first
       responders to help in the reversal of overdoses to save lives
     • Expand resources to promptly identify and treat incarcerated individuals suffering
       from substance use disorders by collaborating with criminal justice stakeholders and
       by providing evidence-based treatment
     • Expand disposal sites for unwanted prescription medications to keep them out of
       the hands of our children and adolescents
     • Launch an evidence-based opioid and heroin treatment and intervention program to
       expand best practices throughout the country
     • Launch a medication assisted treatment (MAT) and intervention demonstration
       program
     • Strengthen prescription drug monitoring programs (PDMP) to help states monitor
       and track prescription drug diversion and to help at-risk individuals access services

 What should Georgia do?
 After a careful review of recent recommendations from the National Safety Council and the National
 Governors Association, SARA proposes a legislative agenda for Georgia as briefly outlined below.
 SARA provides detailed recommendations in the body of this study.
 In addition to the legislative agenda outline below, SARA recommends that the State conduct a
 comprehensive needs assessment specifically related to the opioid crisis and develop both a strategic
 plan and an implementation plan to guide the State’s response to this epidemic.

    Phase I – Georgia’s most urgent needs
    1. Increase access to naloxone.
    More than 1,300 Georgians die each year from prescription opioid and heroin overdoses. Many
    of these deaths could be avoided with the use of naloxone, an opioid antagonist medication
    that reverses opioid overdose without significant negative side effects. First responders,
    parents, and educators should have easy access to naloxone and should have training in how to
    administer the drug.
    2. Improve access to opioid use disorder treatment including medication-assisted
    treatment (MAT) and recovery support services.
    Anyone misusing prescription opioids or using heroin should have access to the full range of
    opioid use disorder treatment services including medically managed detoxification/withdrawal
    management, behavioral therapy, medications and recovery support services. These services
    should include support for 1) families who have members in recovery and 2) community
    organizations that focus on recovery.
                                                                                          (continued next page)

                                                        ©2016 Georgia Prevention Project - All Rights Reserved.   8
EXECUTIVE
Prescription Opioids and Heroin Epidemic in Georgia                                                      SUMMARY

    3. Increase funding for substance misuse prevention programs.
    The Georgia Legislature significantly reduced funding to DBHDD in 2010 for substance misuse
    prevention programs and administration. While DBHDD distributes and manages Federal
    substance misuse prevention funds, total State spending on substance misuse prevention
    within DBHDD currently is only $232,000 per year. Prescription drug education programs should
    target teens, young adults and parents.
    4. Increase funding and improve mechanisms to address neonatal abstinence
    syndrome (NAS).
    Some hospitals in Georgia are overwhelmed with infants born with NAS. The problem is on
    the rise, and these hospitals need significant assistance in treating and managing the care of
    these infants.
    Moreover, health care providers need better education and training on how to deal with NAS. Our
    recommendations focus on three areas: 1) reducing incidence of NAS, 2) reducing NAS severity
    and optimizing health outcomes, and 3) leveraging resources and reducing costs of NAS.
    5. Strengthen the Prescription Drug Monitoring Program (PDMP).
    While Georgia implemented important changes and enhancements to its PDMP during the 2016
    legislative session, much work remains to be done. The PDMP helps track the writing and filling
    of prescriptions of controlled substances, particularly opioid-based painkillers.

    Phase II – Comprehensive and systematic approaches for Georgia
    1. Increase oversight of pain clinics.
    Georgia passed the Pain Management Clinic Act in 2013. Consistent with the National Safety
    Council and the National Governor’s Association recommendations, Georgia should do two
    things: 1) require pain clinics to register with and use Georgia’s PDMP, and 2) conduct an
    evaluation of the legislation to determine if it is being enforced and what impact it has had on
    opioid prescribing and overdose deaths.
    2. Create standards for prescriber education.
    The Georgia Composite Medical Board (CME) should mandate that a minimum of 5 hours
    of the 40 hours of required biannual credit hours focus specifically on the Georgia PDMP,
    pain management, and guidelines for prescribing opioid medications for chronic pain and/or
    substance use disorders.
    Longer term, Georgia should create a task force to address more detailed methods of educating
    all levels of health professionals on pain management and incorporating technology that
    integrates the PDMP more directly with patient electronic health records (EHR).
    3. Create a recurring “blue-ribbon” commission on substance use and recovery.
    The Georgia Legislature, in collaboration with the Governor’s Office, should create a recurring
    commission that convenes every 5-7 years to establish strategy and statewide goals,
    recommend appropriations, and review progress on reducing substance misuse and expanding
    local systems of recovery supports and treatment services in Georgia.

                                                           ©2016 Georgia Prevention Project - All Rights Reserved.   9
EXECUTIVE
Prescription Opioids and Heroin Epidemic in Georgia                                                       SUMMARY

 The Georgia Prevention Project
 The Georgia Prevention Project - SARA’s host             project ran more than 26,000 radio spots,
 organization - is a statewide not-for-profit effort      placed 23,000 television ads, and placed more
 that focuses on reducing the use of dangerous            than 588 billboards all over Georgia. This
 substances among teens and young adults.                 saturation effort significantly changed teens’
 We accomplish our work through awareness                 perceptions of risk about the drug and produced
 campaigns, educational programming and                   results very similar to the Montana program.
 strategic partnerships with national and                 Riding the momentum of the successful “Not
 community based organizations.                           Even Once” Meth prevention campaign, the
 The Georgia Prevention Project evolved from              Georgia Prevention Project launched in 2014
 the Georgia Meth Project founded in 2009.                capitalizing on the Meth Project techniques and
 Created by the Siebel Foundation, the national           expanding its focus to include prescription drug
 Meth Project effort won more than 45 national            misuse and heroin use.
 and international awards for its hard-hitting            The Georgia Prevention Project partners with
 educational campaigns that helped reduce                 community members, schools and prevention
 first-time Meth use by more than 65 percent              professionals to develop strategy, build coalitions
 in its first two years in Montana. Subsequent            and provide drug education resources to bring
 launches in Idaho and Wyoming saw similar                attention to the health and future of youth.
 results and led to the addition of Hawaii,
 Colorado and Georgia as part of the Meth                 Through its Teacher Substance Abuse
 Project family.                                          Training Program, GPP has worked to ensure
                                                          that large numbers of Georgia teens gain
 In Georgia, the campaign led to significant              in-depth knowledge of the risks associated
 changes in teens’ perceptions of risk associated         with the misuse of prescription drugs and
 with Meth. During the media portion of the               the misuse of dangerous substances such as
 campaign of 2010-2012, the Georgia Meth                  methamphetamine and heroin.

 For more information, or                  Jim Langford
 to discuss this Executive                 Executive Director, Georgia Prevention Project; Chair, SARA
 Summary, please contact us.               3715 Northside Parkway
                                           Suite 1-320
                                           Atlanta, GA 30327
                                           404-831-1959
                                           Email: info@georgiapreventionproject.org;
                                                   jlangford@georgiapreventionproject.org
                                           Web sites:     www.georgiamethproject.org;
                                           		www.georgiapreventionproject.org

                                                            ©2016 Georgia Prevention Project - All Rights Reserved.   10
Prescription Opioids and Heroin
Epidemic in Georgia

- Findings and Policy Recommendations

2017
                                        ©2016 Georgia Prevention Project - All Rights Reserved.
FINDINGS & POLICY
Prescription Opioids and Heroin Epidemic in Georgia                                          RECOMMENDATIONS

 I. Opioid Overview

 1. What opioids are
 Opioids are a class of drugs that act on the       a neurotransmitter used in the brain’s pleasure
 body’s opioid receptors including natural, semi-   or reward system. When activated, dopamine
 synthetic and synthetic opioids. Natural opioids   produces a pleasurable, often euphoric feeling,
 include drugs such as                              which contributes to opioid misuse, as people
                                                    seek to repeat these sensations.
   • morphine, derived from the resin of the
     opium poppy                                    Use of opioids for more than a short period
   • semi-synthetic opioids such as                 of time leads to tolerance, physical and
     hydrocodone and oxycodone                      psychological dependence. This means opioid
                                                    users must take larger doses of opioids over
   • synthetic opioids such as fentanyl and         time to achieve the same effect. Additionally,
     methadone                                      opioid users must not stop taking these drugs
 Opioids are often used medically to relieve        abruptly or they will experience withdrawal
 moderate to severe pain, but can also be           symptoms such as: agitation, anxiety, muscle
 used for example, to suppress cough, treat         and bone pain, insomnia, vomiting or diarrhea.
 diarrhea, and even treat opioid use disorder.      Withdrawal symptoms occur when the amount
 Opioids are very effective for treating severe     of opioids decrease or are stopped.
 pain such as that associated with cancer, post-    “Substance use disorders are a chronic medical
 surgery or accident-related injuries. While        illness characterized by clinically significant
 opioids provide pain relief, they also cause       impairments in health, social function and
 physical dependence, respiratory depression,       voluntary control over substance use (not a moral
 euphoria, reduced intestinal motility and other    failing or character flaw).” - Surgeon General’s
 desired and undesired effects. Since these         Report, Facing Addiction in America, 2016.
 pharmacologic effects focus on blocking pain,
 opioids have high potential for misuse.            3. The U.S. Opioid epidemic
 2. How opioids affect the human body               In 2015, overdose deaths associated with
                                                    prescription and illicit opioids increased to
 Opioid drugs mimic the body’s natural              33,091, from 28,647 in 2014 (CDC), suggesting
 response to pain by stimulating the body’s         that 90 people die daily on average in the
 opioid receptors, most prominently the Mu (μ)      U.S. from opioid overdoses. Over the past
 receptors. Mu receptors account for most of        15 years, overdose deaths related to opioids
 the effects of opioids and are primarily located   have reached epidemic proportions (Rudd et
 in the brain, spinal cord, peripheral nervous      al., 2015). The rate of opioid-related overdose
 system, and intestinal tract.                      deaths has increased over 200% since 2000.
 By stimulating the Mu receptors, opioids reduce    Between 2011 and 2015, deaths related to
 the perception of pain by slowing down and         heroin more than tripled to 12,990 (National
 blocking pain signal transmission to the brain,    Center for Health Statistics).
 while also triggering the release of dopamine,

                                                      ©2016 Georgia Prevention Project - All Rights Reserved.   12
FINDINGS & POLICY
Prescription Opioids and Heroin Epidemic in Georgia                                           RECOMMENDATIONS

 Despite these staggering increases in deaths        Studies show a shift in the demographics of
 related to opioid overdose, the number of           heroin users in recent years. In the 1960s,
 prescriptions written for opioid analgesics         those initiating heroin use were predominantly
 continues to increase (Volkow et al. 2014).         young men from minority groups living in urban
 The number of written prescriptions for opioid      areas. Now those initiating heroin use tend
 medications rose from 75.5 to 209.5 million over    to be somewhat older (mean age of first use
 the past decade (National Institutes of Health,     is 22.9 years compared to 16.5 years), more
 2014). According to a recent report, sales of       concentrated in rural and suburban areas, and
 opioid analgesics quadrupled from 1999 to 2010      white (Cicero et al., 2014).
 (Frenk et al., 2015).
                                                      According to the CDC, people at highest
 Misuse of prescription opioids and heroin           risk for heroin addiction are those addicted
 use is also on the rise. In 2015, approximately     to prescription opioid painkillers, cocaine,
 12.5 million Americans reported misusing            marijuana and alcohol, people 18 to 25 years
 pain relievers in the previous year and 2.0         of age living in large metropolitan areas,
 million Americans had a pain reliever drug use      and people without insurance or enrolled in
 disorder (SAMHSA, 2016). In the same year,          Medicaid (CDC, 2016 http://www.cdc.gov/
 approximately 914,000 Americans reported            vitalsigns/heroin/).
 use of heroin and 519,000 Americans met
                                                     4. Relationship between nonmedical use of
 diagnostic criteria for a heroin use disorder
                                                     prescription opioids and heroin use
 (SAMHSA, 2016). The cost of prescription
 opioid misuse is high, estimated at $78.5 billion   Studies found that about 80% of heroin
 in 2013 alone (Florence et al., 2016). Also see     users reported using prescription opioids for
 opioids deaths by type of opioid: heroin: 2014      nonmedical reasons before beginning use of
 chart (Kaiser Family Foundation) in Appendix.       heroin (Jones, 2013; Muhuri et al. 2013).
 The highest rates of prescription opioid            Overall, these studies suggest a link between
 overdose deaths from 1999 to 2014 were              nonmedical use of prescription opioids and
 among non-Hispanic whites and American              heroin, particularly among people with frequent
 Indian or Alaskan Natives, persons aged 25 to       nonmedical use, or people with prescription-
 54, and men. The rates of prescription opioid       opioid use disorder. However, it is important
 overdose deaths are on the rise for women           to note that only a small percentage (less than
 (CDC, 2016).                                        5% of people who use prescription opioids for
                                                     nonmedical reasons) begin using heroin. This
                                                     small percentage translates to several hundred
   Risk factors for prescription opioid
                                                     thousand new heroin users per year and should
   misuse and overdose:
                                                     not be minimized (Compton et al., 2016).
    • doctor shopping (i.e., receiving
      overlapping prescriptions from multiple        While some argue that implementation of
      providers and pharmacies)                      policies to address misuse and inappropriate
                                                     prescribing of prescription opioids (e.g.,
    • taking high daily doses of prescription
      pain relievers                                 PDMPs) could be a driver of increased deaths
                                                     from heroin overdose, there is little empirical
    • having mental illness or a history of
                                                     evidence of a causal link. Instead, the evidence
      substance abuse
                                                     suggests that market forces such as increased
    • being low-income                               availability, reduced price and increased purity
    • living in a rural area                         of heroin could be more important drivers
                                      (CDC, 2016).   of increased heroin use and heroin overdose
                                                     deaths (Compton et al., 2016).
 See Appendix for opioids overdose deaths by         Public health efforts to address either
 Type of Opioid: Heroin, 2014. Kaiser Family         prescription opioids or heroin use must consider
 Foundation State Health Facts.                      interrelationships between prescription opioid

                                                       ©2016 Georgia Prevention Project - All Rights Reserved.   13
FINDINGS & POLICY
Prescription Opioids and Heroin Epidemic in Georgia                                                                                                                                   RECOMMENDATIONS

 and heroin use and focus on a comprehensive                                                                               100,000 persons in the U.S. occurred during the
 approach that includes all levels of prevention                                                                           same time period.
 (i.e., primary, secondary, and tertiary), with
                                                                                                                           However, the rate of increase in opioid deaths
 emphasis on harm reduction approaches as a
                                                                                                                           in Georgia was much higher than the rate of
 principal tertiary prevention strategy (Kolodny et
                                                                                                                           increase of opioid deaths in the U.S. Sales of
 al., 2015).
                                                                                                                           opioids also quadrupled in the U.S. between
 5. Impact of opioid use                                                                                                   1999 and 2014.
   a. Overdose deaths in Georgia                                                                                           Similar to national trends, deaths related to
                                                                                                                           opioid overdose continue to rise in Georgia.
 Opioid overdose death rates including heroin in
                                                                                                                           Even more alarming, recent data from the
 Georgia increased significantly - from 0.6 to 5.5
                                                                                                                           Georgia Department of Public Health indicate
 per 100,000 persons between 1999 and 2014 -
                                                                                                                           that deaths related to drug overdose surpassed
 while a comparable increase from 1.4 to 5.9 per
                                                                                                                           deaths due to motor vehicle crashes in 2014.

 Figure 1:
        Deaths Related to Drug Overdose and Motor Vehicle Crashes, Georgia, 2001-2015
                                                                                             1,673
                                                                               1,670
                                                                 1,568
        1,509

                       1,492

                                                   1,482

                                                                                                           1,456
                                     1,387

                                                                                                                                                                                            Source:

                                                                                                                                                                                    1,345
                                                                                                                                                                                   1,307
                                                                                                                                                                           1,274
                                                                                                                       1,253

                                                                                                                                             1,248
                                                                                                                                  1,223

                                                                                                                                                                  1,223

                                                                                                                                                                          1,219
                                                                                                                                                                                            Georgia

                                                                                                                                                        1,177

                                                                                                                                                                1,125
                                                                                                                                          1,070

                                                                                                                                                      1,059
                                                                                                                               1,074

                                                                                                                                                                                            Department
                                                                                                                   1,006
                                                                                                     956

                                                                                                                                                                                            of Public
                                                                                       859
                                                                         767

                                                                                                                                                                                            Health,
                                             697

                                                           682
                               647
                 611

                                                                                                                                                                                            Office of
  559

                                                                                                                                                                                            Health
                                                                                                                                                                                            Indicators
                                                                                                                                                                                            for
   2001          2002           2003         2004          2005          2006          2007          2008          2009        2010       2011        2012      2013      2014     2015
                                                                                                                                                                                            Planning,
                                                                                                      Drug Overdose Deaths                           Motor Vehicle Crash Deaths             Death files.

 Opioids, primarily prescription pain relievers and                                                                        Further, the state experienced a statistically
 heroin, are the main driver of drug overdose                                                                              significant 10.2% increase in the overdose death
 deaths. Of the 1,307 overdose deaths in 2015                                                                              rate from 2013 to 2014 (CDC, 2016), and a tripling
 in Georgia, 900, or 88% were due to opioids.                                                                              of overdose deaths between 1999 and 2013.

 Figure 2:
   Number of Drug Overdose Deaths Related to Opioids
   including Heroin in Georgia, 2001-2015                                                                                                                                  1,274
                                                                                                                                                                                    1,307

                                                                                                                               1,074       1,070       1,059     1,125
                                                                                                                   1,006
                                                                                                      956
                                                                                       859                                                                                          900
                                                                         767                                                                                                795
                                             697           682                                                                                                                Source:
                               647                                                                                                          622         633
                611                                                                                                             600                               606         Office of
  559                                                                                                               554
                                                                                                     467                                                                      Health
                                                                                       380                                                                                    Indicators
                               265           277           294
   243          246                                                      242                                                                                                  for Planning
                                                                                                                                                                  90 121      (OHIP),
   3                                          2             3             1              6            20              16          3         25      31     48
                 1              5                                                                                                                                             Georgia
                                                                                                                                                                              Department
 2001           2002           2003          2004          2005          2006          2007          2008          2009         2010       2011    2012   2013 2014      2015
                                                                                                                                                                              of Public
        All Drug Overdose Deaths                                 Opioid Overdose Deaths, Including Heroin                                      Heroin Overdose Deaths, Only   Health.

                                                                                                                                ©2016 Georgia Prevention Project - All Rights Reserved.                    14
FINDINGS & POLICY
Prescription Opioids and Heroin Epidemic in Georgia                                                         RECOMMENDATIONS

 Prescription opioid overdose deaths also significantly increased in Georgia, according to the CDC
 WONDER Online Database (see Figure 6, retrieved from http://wonder.cdc.gov/mcd-icd10.html).

 Figure 3:

           Number of Prescription Opioid Overdose Deaths in Georgia, 2001-2015                               Source: Centers
                                                                                              588            for Disease
                                                                                                      549    Control and
                                                                         498    488                          Prevention
                                                                  464                                        (CDC), National
                                                           448                         441
                                                                                                             Center
                                                    362                                                      for Health
                                             348
                                      308
                                                                                                             Statistics.
                               270                                                                           Multiple Cause
                                                                                                             of Death
                        221
                 186                                                                                         1999-2014 on
          171
   152                                                                                                       CDC WONDER
                                                                                                             Online
                                                                                                             Database. Data
                                                                                                             are from the
                                                                                                             Multiple Cause
                                                                                                             of Death Files,
   2001   2002   2003   2004   2005   2006   2007   2008   2009   2010   2011   2012   2013   2014   2015    1999-2015.

 While 50 prescription opioid overdose deaths                     It is important to note that 60% of the 55
 occurred in 1999, resulting in a rate of 0.6 per                 counties with overdose rates that were higher
 100,000 age-adjusted deaths, the most recent                     than the national average in 2014 are located in
 available data show a tenfold increase to                        rural areas.
 588 deaths, or a rate of 5.8 per 100,000 age-
                                                                  6. Economic costs of opioid misuse in Georgia
 adjusted deaths, in 2014.
                                                                  and the United States
                                                                  The economic burden of prescription opioid
         This puts Georgia in the                                 overdose, misuse and dependence in the U.S.
    top 11 states nationwide with the                             was estimated at $78.5 billion in 2013 with over
        most prescription opioid                                  one third of this amount coming from increased
                                                                  healthcare and substance use treatment costs
            overdose deaths.                                      ($28.9 billion) (Florence et al., 2016). The
                                                                  healthcare costs associated with opioid misuse
   b. How Georgia compares to other states and                    in Georgia alone were estimated at $447 million
   the nation                                                     in 2007 and the estimated per-capita costs were
                                                                  $44 in Georgia.
 While Georgia has a lower rate of all drug
 overdose deaths (11.9 per 100,000) compared to                   Given the increase in overdose deaths and
 the U.S. average (14.7 per 100,000) (CDC, 2016),                 use of opioids in Georgia since 2007, some
 55 of the 159 counties in the state had higher                   experts have estimated a rise in those costs of
 rates than the U.S. average in 2014 (CDC/NCHS,                   at least as 80% since that time. Those same
 National Vital Statistics System, mortality data                 experts agree that the state needs to monitor
 (see http://www.cdc.gov/nchs/deaths.htm); and                    the escalation. Hospitalizations related to
 Health Indicators Warehouse (see http://www.                     opioid use and dependence in Georgia also
 healthindicators.gov/Indicators/Drug-poisoning-                  have skyrocketed from about 302,000 in 2002
 deaths-per-100000_10016/Profile).                                to about 520,000 in 2012. Similarly, the cost of
                                                                  opioid related inpatient care more than doubled
 This marks a significant increase from 11 years
                                                                  during the same time period, rising to $15 billion
 ago, when just 26 counties in Georgia had
 overdose death rates that were higher than the
                                                                  in 2012.                           3
 U.S. average.

                                                                     ©2016 Georgia Prevention Project - All Rights Reserved.   15
FINDINGS & POLICY
Prescription Opioids and Heroin Epidemic in Georgia                                               RECOMMENDATIONS

 II. Key Georgia
     Issues

 1. Overdose reversal
 Naloxone, available since 1971, is an                   allowing pharmacists to dispense naloxone,
 opioid antagonist used to reverse opioid                and passing Good Samaritan legislation.
 overdose through intravenous, intranasal                The National Safety Council and Governors
 (NARCAN® Nasal Spray), and intramuscular                Association submitted recommendations in
 formulations. Intramuscular delivery is available       2016 for increasing access to naloxone (NSC,
 by syringe in various generic forms or by auto-         2016; NGA, 2016). See Appendix.
 injector (EVZIO®).
                                                         Georgia’s Naloxone Legislation
 Naloxone is highly effective and safe and quickly
                                                         House Bill 965, the Georgia 911 Medical
 (within a few minutes) restores breathing. It
                                                         Amnesty Law, signed on April 24, 2014,
 binds to opioid receptors, blocking the effects
                                                         expanded access to naloxone. The law
 of opioids and endorphins. Side effects include
                                                         authorizes administration of naloxone by
 withdrawal symptoms in most cases; while they
                                                         trained first responders (law enforcement,
 are uncomfortable, they are not life threatening.
                                                         firefighters, EMS personnel) for overdose
 It produces no effect in persons who do
                                                         reversal. Additionally, the law allows for
 not have opioids present. Naloxone is not
                                                         medical professionals to write naloxone
 designated as a controlled substance and does
                                                         prescriptions, in good faith, to those at risk of
 not produce tolerance.
                                                         opioid-related overdose.
 Because the nature and concentration of the
                                                         This law also allows for administration of
 opioid causing the overdose is unknown,
                                                         naloxone by lay people to persons suspected of
 treatment may require multiple doses of
                                                         experiencing an opioid overdose and provides
 naloxone depending on the severity of
                                                         protection from arrest and prosecution for
 respiratory depression. Fentanyl (50 to
                                                         people who call 911 seeking medical assistance
 100 times more potent than morphine) or
                                                         for those experiencing alcohol or other drug-
 Carfentanil (10,000 times more potent than
                                                         related overdose.
 morphine) may unknowingly be present
 in other substances (e.g., heroin, cocaine,             Ultimately this means that neither the
 marijuana, counterfeit benzodiazepines, etc.),          caller nor victim can be arrested, charged,
 significantly increasing overdose risk due to           or prosecuted for small amounts of drugs,
 high concentration of opioids in undetectable           alcohol, or drug paraphernalia if the evidence
 quantities (e.g., size of a grain of salt or smaller)   was obtained as a result of seeking medical
 and require more doses to reverse overdose.             assistance. This is important because the timely
                                                         administration of naloxone has been proven to
 States can increase access to naloxone through
                                                         reverse the effects of opioids such as heroin
 a number of mechanisms including allowing
                                                         and opioids including hydrocodone, oxycodone,
 naloxone to be prescribed with standing orders,
                                                         methadone and others drugs.

                                                           ©2016 Georgia Prevention Project - All Rights Reserved.   16
FINDINGS & POLICY
Prescription Opioids and Heroin Epidemic in Georgia                                            RECOMMENDATIONS

 Victims of opioid overdose who                       Georgia Overdose Prevention. GOP
 receive naloxone in time are less likely to die or   (georgiaoverdoseprevention.org) is
 suffer long-term brain or tissue damage than         a grassroots organization of parents,
 those who do not. Removing barriers to health-       healthcare professionals, harm reduction
 seeking behavior is a crucial step in the fight      advocates and friends of those who have
 against opioid related deaths.                       lost loved ones to accidental drug overdose.
                                                      GOP formed to create and advocate for the
 Naloxone Availability in Georgia
                                                      passage of the Georgia 911 Medical Amnesty
 Pharmacies. Naloxone is available from some          Law described above. The GOP provides
 pharmacies in Georgia. Individuals can ask           overdose reversal training and a simple
 for naloxone without bringing in their own           message based on the belief that when one is
 prescription at pharmacies because of standing       breathing, there is still hope: Don’t run, call 911.
 orders that allow dispensing to individuals who
                                                      First Responders. The extent to which police
 meet specified criteria. Georgia residents may
                                                      departments, fire departments, and emergency
 obtain Narcan without a prescription from
                                                      medical services have naloxone available across
 Georgia pharmacies.
                                                      the state is unknown. Not all police precincts
 Adapt Pharma, a manufacturer of naloxone,            have naloxone, and precincts differ in the
 provides a naloxone prescription request form        availability of naloxone to officers. Cost and the
 with a National Drug Code (NDC) number to            shelf life of naloxone are concerns.
 facilitate filling the prescription by pharmacies.
                                                      Medical settings. Naloxone availability or
 However, no centralized information exists on
                                                      distribution from various types of medical
 which pharmacies in Georgia carry naloxone.
                                                      settings is unknown. Autoinjectors have
 Individuals need to contact pharmacies directly
                                                      been distributed free of charge from EVZIO®
 to find out whether the pharmacy carries it and
                                                      donations to opioid treatment provider clinics.
 how to obtain it.
                                                      Schools. Because overdose may occur in
 The Georgia Pharmacy Association participated
                                                      schools, naloxone availability in schools is
 in Project DAN (Deaths Avoided by Naloxone) to
                                                      receiving increasing attention. The National
 help make naloxone available to pharmacies and
                                                      School Nurses Association sees naloxone
 first responders. Georgia Pharmacy Foundation
                                                      availability in schools as an element of a
 partnered with Medical Association of Georgia
                                                      school’s emergency and response plan for safe
 (MAG) Foundation’s Think About It campaign to
                                                      and effective reversal of opioid pain reliever
 distribute naloxone to pharmacies in 13 northeast
                                                      overdose.
 counties in 2015. This effort included working to
 encourage pharmacies to carry naloxone.              Adapt Pharma is offering NARCAN free to
                                                      schools around the country. The Clinton
 Community organizations that legally can hand
                                                      Foundation’s Health Matters Initiative is a
 out naloxone (syringe kits or Narcan) are those
                                                      partner in this effort. (http://www.drugfree.
 with a standing order prescription on file from a
                                                      org/news-service/naloxone-offered-free-high-
 medical director, and a pharmacy through which
                                                      schools-around-country/) Pennsylvania was
 to order the prescription.
                                                      the first state to make naloxone available in all
 Two organizations meet these criteria – the          public schools through this program (http://
 Georgia Overdose Prevention and the Davis            fox43.com/2016/02/01/heroin-overdose-drug-
 Direction Foundation. Naloxone kits are              naloxone-to-be-provided-free-to-all-pa-public-
 distributed through the Atlanta Harm Reduction       schools/). States, such as Vermont, Delaware,
 Coalition by the Georgia Prevention Project.         Illinois, and New York have made naloxone
 Availability is supported by grant funding from      available in schools.
 DBHDD and donations.
                                                      Home. Naloxone availability at home provides
                                                      for rapid overdose reversal. Overdose may
                                                      occur not only from heroin use and non-
                                                      prescription use of opioid medications, but

                                                        ©2016 Georgia Prevention Project - All Rights Reserved.   17
FINDINGS & POLICY
Prescription Opioids and Heroin Epidemic in Georgia                                           RECOMMENDATIONS

 also from prescription use. Errors in use,             does not directly address reducing opioid
 sharing of medications, and use according              misuse. There is no evidence that availability
 to prescription may result in overdose. Co-            of life saving overdose reversal medication
 prescribing of naloxone with opioid medication         increases opioid overdose risk.
 can reduce overdose. (Coffin et al., 2016;
                                                     2. Awareness, availability, and training on use.
 https://www.drugabuse.gov/news-events/
                                                        Limited awareness about the potential for
 news-releases/2016/06/co-prescribing-
                                                        overdose and the availability of overdose
 naloxone-in-primary-care-settings-may-reduce-
                                                        reversal medication is a concern among
 er-visits). H.R. 3680 - Co-Prescribing to Reduce
                                                        those who may encounter opioid overdose
 Overdoses Act of 2016 was passed by the U.S.
                                                        but who have not been properly trained on
 House of Representatives in May 2016 and
                                                        administration procedures.
 is under review by the Senate. https://www.
 congress.gov/bill/114th-congress/house-             3. Cost of medication and medication
 bill/3680/text                                         expiration.
 Escalating Naloxone Cost                            4. Limited data on reversals. The ability
                                                        to track overdose reversals is limited to
 Naloxone costs have increased substantially
                                                        documentation by first responders and
 over the past decade, particularly since 2014.
                                                        emergency rooms. Information from
 Naloxone increased from $.92 per dose in 2005
                                                        multiple sources needs to be collected and
 to $15 - $17 per dose by one manufacturer
                                                        validated in a single system.
 in 2014 and up to $41 per dose in 2015 by
                                                        When naloxone is administered by
 another. Narcan costs $63 per single dose, but
                                                        individuals without the involvement of
 sells at about half that cost to government
                                                        first responders or medical services, no
 agencies, community organizations and those
                                                        information on use is available. A system
 without insurance.
                                                        for centralized data collection from entities
 The cost of Evzio auto-injectors is substantially      that distribute naloxone would provide more
 higher, having jumped in price from $287.50            accurate information.
 in July 2014 to $375 in November 2015, with
                                                     5. Linkage to services following reversal.
 further increases in 2016 to $2,250 per single
                                                        Successful overdose reversals without linkage
 dose. Since scrutiny of these prices increases,
                                                        to services to reduce or prevent future
 manufacturers have responded with discounts
                                                        overdose of the same individual is a concern.
 and rebates. ADAPT makes Narcan available
                                                        First responders report multiple reversals
 free of charge to schools and has donated
                                                        on the same individual. Furthermore,
 50,000 doses, and Kaleo has donated 150,000
                                                        subsequent overdoses may lead to
 autoinjectors to first responders and nonprofits.
                                                        death because intervention with reversal
 Most insurance covers naloxone including               medication did not occur in time. Evidence-
 Medicaid, and EVZIO promotes a zero                    based, effective systems are needed to link
 co-pay option.                                         individuals experiencing an overdose reversal
                                                        to services preferably via assertive case
 Naloxone Concerns
                                                        management and warm hand-offs.
 Although Georgia has made progress in this
                                                     At present, Georgia Department of Behavioral
 area, additional efforts to increase access to
                                                     Health and Developmental Disabilities (DBHDD)
 naloxone are needed. General concerns about
                                                     is developing business-card size materials to
 naloxone fall into the five areas: outline below.
                                                     distribute. More effective measures for reducing
 1. Possible perception as safety net for risk       repeat overdose are needed, such as creating
    opioid use. Some groups and individuals          linkage directly between individuals who can
    are concerned that availability of overdose      provide direct, culturally congruent support and
    reversal medication may be perceived             ongoing recovery services. These efforts have
    as a safety net by opioid users at risk of       been put in place in other communities, and
    overdose, and that naloxone availability         need exploration for their use in Georgia.

                                                       ©2016 Georgia Prevention Project - All Rights Reserved.   18
FINDINGS & POLICY
Prescription Opioids and Heroin Epidemic in Georgia                                       RECOMMENDATIONS

                                                 2. Medication assisted treatment & recovery
   SARA Makes the Following                      support services
   Recommendations Regarding
                                                 To meet the needs of patients with OUD, it is
   Medications
                                                 important for patients to have access to the full
   1. Increase awareness about overdose and      range of SUD treatment services including:
      overdose reversal medication.
                                                      • outpatient treatment
   2. Increase access to naloxone and training
                                                      • intensive outpatient treatment
      on use of the medication.
                                                      • residential treatment
   3. Develop a plan to address
      naloxone cost.                                  • detoxification
   4. Implement information technology                • medications
      systems to improve tracking of                  • recovery support services
      naloxone use.
                                                                                              (ASAM, 2016).
   5. Establish immediate linkages to recovery
      services following overdose reversal to    According to a National Safety Council report,
                                                 Georgia does not meet the indicator for
      • reduce the potential for repeat          “meets need for OUD treatment”, measured by
        overdose, and                            sufficient buprenorphine treatment capacity.
      • increase the likelihood of sustained     Ongoing treatment and recovery support of
        recovery                                 individuals affected by opioid use disorders
   6. Mandate Insurance Coverage for             involves addressing physical dependence
      Opioid Overdose-Reversal Medication:       (including overdose risk) and the behavioral
      Naloxone revives an individual from a      and psychosocial skills required for managing
      heroin or other opioid overdose and has    recovery. Treatment decisions could depend
      saved thousands of Georgians’ lives.       upon a range of factors including substance
                                                 use history (e.g., duration, substances used,
      It has no psychoactive effects and         prior recovery efforts), co-occurring disorders,
      concomitantly, no misuse potential.        treatment availability, cost/payment options,
      To expand access to this life-saving       family support, and legal requirements.
      medication, the new legislation requires   Behavioral counseling, a key component of
      insurance companies to cover the costs     Georgia’s recovery-oriented systems of care for
      of naloxone when prescribed to a person    opioid addiction, generally follows the National
      who is addicted to opioids and/or to       Institute on Drug Abuse (NIDA)’s Principles
      his/her family member/s on the same        of drug addiction treatment: A research-
      insurance plan.                            based guide (2012; 3rd edition: drugabuse.
                                                 gov/publications/principles-drug-addiction-
                                                 treatment/evidence-based-approaches-to-drug-
                                                 addiction-treatment/behavioral-therapies).
                                                 How Georgia’s public behavioral health
                                                 treatment system is managed currently
                                                 The Department of Behavioral Health and
                                                 Developmental Disabilities’ mission is to lead
                                                 an accountable and effective continuum of
                                                 care to support Georgians with behavioral
                                                 health challenges, and intellectual and
                                                 developmental disabilities in a dynamic
                                                 healthcare environment. State funds and federal

                                                   ©2016 Georgia Prevention Project - All Rights Reserved.    19
FINDINGS & POLICY
Prescription Opioids and Heroin Epidemic in Georgia                                            RECOMMENDATIONS

 block grants support a network of six regional       opioid detoxification services and medication
 offices that administer each region’s hospital       extremely limited in Georgia.
 and community resources. (Community
                                                      Medications to manage withdrawal
 services are provided through contracts with
                                                      symptoms during detoxification from
 private, for-profit, non-profit, and quasi-public
                                                      opioids include methadone, buprenorphine
 agencies under contract with DBHDD through
                                                      alone or with naloxone (Suboxone®), milder
 the regional offices. Services focus on addictive
                                                      opioids, and clonidine. The length of the
 diseases, behavioral health, behavioral health
                                                      detoxification process varies by individual
 prevention and other services.
                                                      factors and goals. It may include use of
 Key Terms and Implications                           multiple medications concurrently or
                                                      sequentially. Individual differences may
 Medication-assisted Treatment (MAT)
                                                      include level of tolerance, substances used,
 Medication-assisted treatment (MAT) refers           length of use, and medical complications.
 to multi-faceted individualized substance use
                                                       In addition to becoming opioid free, goals
 disorder treatment models that employ both
                                                      may include transition to methadone,
 medications and other services and supports for
                                                      buprenorphine, or extended-release injectable
 recovery maintenance.
                                                      naltrexone, each of which may affect length of
 The Georgia Department of Behavioral Health          time required. Transition to extended-release
 and Developmental Disabilities (DBHDD)               injectable naltrexone requires a 7-10 day opioid
 recognizes that MAT provides specific                free period to avoid precipitating withdrawal.
 interventions for reducing and/or eliminating the
                                                      Gaps in medication may make an individual
 use of illicit opioids and other drugs of misuse;
                                                      vulnerable to using substances in their
 while developing the individual’s social support
                                                      recovery process. Establishing systems for the
 network and necessary lifestyle changes;
                                                      most effective implementation of treatment
 psychoeducational skills; pre-vocational skills
                                                      protocols can lessen these vulnerabilities and
 leading to work activity (by reducing substance
                                                      provide greater supports for recovery.
 use as a barrier to employment); social and
 interpersonal skills; improved family functioning;   Management of tapers or transitions
 the understanding of addictive disease; and          from the opioid agonists, methadone or
 the continued commitment to a recovery and           buprenorphine, to extended-release injectable
 maintenance program.                                 naltrexone could be affected by approved
                                                      usage of transitional medications.
 Medically Managed Detoxification/Withdrawal
 Management                                           Reduction in use of methadone and
                                                      buprenorphine requires a long taper. The
 Opioid withdrawal, whether from prescription
                                                      length of the taper can be reduced with use of
 medication or heroin, often produces extreme
                                                      alternative medications, such as milder opioids,
 and extended discomfort. Symptoms include:
                                                      which may not be approved for opioid tolerance
 sweating, shaking, chills, body aches, yawning,
                                                      management. Longer tapers increase cost and
 large pupils, headache, drug craving, nausea,
                                                      impact the viability of transitioning clients.
 vomiting, abdominal cramping, diarrhea,
 inability to sleep, confusion, agitation,            Access to medically managed detoxification for
 depression, anxiety, … and other behavioral          opioids and other substances differs broadly
 changes, and can last for days and weeks.            across the country, from no availability to
 Fear of withdrawal symptoms is a significant         free walk-in 24/7, for anyone, regardless of
 deterrent to discontinuing opioid use, and a         insurance status.
 frequent reason for relapse.
                                                      Outpatient and inpatient options might be
 Because opioid withdrawal is not considered          appropriate for opioid detoxification. Insurance
 life threatening, detoxification is generally not    coverage restrictions, as well as lack of available
 covered by Medicaid and private insurance,           beds or outpatient services, limit access to
 making access to inpatient or outpatient             detoxification for many individuals ready to

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