Prescription Opioids and Heroin Epidemic in Georgia
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Prescription Opioids SARA Executive Committee Jim Langford – Chair, SARA; Executive Director, and Heroin Epidemic Georgia Prevention Project in Georgia Dr. Amanda Abraham – Assistant Professor, School of Public and International Affairs, University of Georgia - A White Paper Dr. Aaron Johnson – Associate Professor, Institute of Public and Preventive Health, Augusta University Dr. Merrill Norton – Clinical Associate Professor, College of Pharmacy, University of Georgia Dr. Glenda Wrenn – Associate Professor, Director of Behavioral Health, Satcher Health Leadership Institute, Director, Kennedy Center for Mental Health Policy, Morehouse School of Medicine 2017 ©2016 Georgia Prevention Project - All Rights Reserved.
TABLE OF Prescription Opioids and Heroin Epidemic in Georgia CONTENTS Contents Prescription Opioids and Heroin Epidemic in Georgia Executive Summary Findings and Policy Recommendations I. Opioids overview III. Proposed legislative agenda 1. What opioids are for Georgia 2. How opioids affect the human body 1. Increase access to Naloxone 3. The U.S. opioid epidemic 2. Improve access to opioid use disorder treatment, including medication assisted 4. Relationship between nonmedical use of treatment (MAT and recovery support prescription opioids and heroin use services) 5. Impact of opioid use 3. Increase state funding for substance abuse a. Overdose deaths in Georgia prevention education b. How Georgia compares to other states 4. Increase funding and improve and the nation mechanisms for addressing neonatal abstinence syndrome (NAS) 6. Economic costs of opioid misuse and abuse in Georgia and the United states 5. Strengthen the Prescription Drug Monitoring Program (PDMP) 6. Increase oversight of pain clinics II. Key Georgia issues 7. Create standards for physician education 1. Overdose reversal 8. Create a “blue ribbon” commission on 2. Medication assisted treatment & recovery substance use recovery supports and support services recovery-oriented systems of care 3. Prevention education 4. Neonatal abstinence syndrome IV. Appendix 5. Controlling access to opioids V. Resources a. Prescription Drug Monitoring Program b. Pain clinics c. Prescriber education ©2016 Georgia Prevention Project - All Rights Reserved. 2
EXECUTIVE Prescription Opioids and Heroin Epidemic in Georgia SUMMARY Introduction Substance Abuse Research Alliance (SARA) is a program of the Georgia Prevention Project, and it initiated this study in April of 2016 as the organization’s first collaborative project with a primary goal to assist the Georgia State Senate Study Committee on Opioids and Heroin in its work. With more than 60 participants, SARA includes researchers and practitioners with a wide spectrum of experience in substance misuse work. SARA participants represent the following organizations: • Applied Research Services, Inc. • Georgia State University – multiple • Augusta University departments and programs • Carter Center Mental Health Program • Lab Solutions, Inc. • Centers for Disease Control and Prevention • Mercer School of Medicine • Emory University – multiple departments • Morehouse School of Medicine – multiple and programs departments and programs • Georgia Council on Substance Abuse • Parkaire Consultants, Inc. • Georgia Department of Behavioral Health • Partnership for Drug-Free Kids and Developmental Disabilities (DBHDD) • Skyland Trail • Georgia Department of Public Health (DPH) • The Council on Alcohol and Drugs • Georgia Prevention Project • University of Georgia – multiple departments • Georgia Southern University and programs SARA believes that opioid and heroin use in Georgia seriously threatens the What you need to know now health, prosperity and general well- being of Georgians throughout the The U.S. state, across almost all sectors of life 200 percent prescription opioid overdose (OD) deaths and work. increase since 2000 Like Georgia, several other states struggle 125 million Americans who reported misusing prescription pain relievers in the past year over how to ameliorate the suffering and death rates associated with prescription 80 percent of heroin users reported using opioids and heroin, how to prevent prescription opioids for non-medical reasons before beginning to use heroin citizens from misusing these substances, and how to intervene effectively to treat Georgia opioid use disorder and promote long- term recovery. 549 opioid drug ODs in 2015 29 counties where drug OD rates outpace U.S. average SARA stands ready to assist the Georgia Legislature and the State Senate Study 11 Georgia ranks among top 11 states with most prescription opioid OD deaths Committee in any way that we can. ©2016 Georgia Prevention Project - All Rights Reserved. 3
EXECUTIVE Prescription Opioids and Heroin Epidemic in Georgia SUMMARY Executive Summary Georgia’s prescription opioid and heroin opioid receptors, most prominently the Mu (μ) problem threatens the well-being of every receptors. Mu receptors account for most of Georgian at every socio-economic level and in the effects of opioids and are primarily located every geographic region of the state. in the brain, spinal cord, peripheral nervous system, and intestinal tract. This study by the Substance Abuse Research Alliance (SARA) seeks to educate public By stimulating the Mu receptors, opioids officials and the general public about the opioid reduce the perception of pain by slowing epidemic that is devastating communities down and blocking pain signal transmission across the country and here in Georgia. We to the brain while also triggering the release answer key questions and also offer a proposed of dopamine, a neurotransmitter used in legislative agenda to consider as Georgia the brain’s pleasure or reward system. When legislators move to address this pervasive and activated, dopamine produces a pleasurable growing challenge in our lives and communities. and often euphoric feeling. What Are Opioids? How Do They Use of opioids for more than a short period Affect The Human Body? of time leads to tolerance and physical and psychological dependence. This means opioid Opioids are a class of drugs that act on the users must take larger doses of opioids over body’s opioid receptors including natural, time to achieve the same effect. Additionally, semi-synthetic and synthetic opioids. Natural opioid users must not stop taking these drugs opioids include drugs such as morphine, which abruptly, or they will experience withdrawal are derived from the resin of the opium poppy, symptoms such as agitation, anxiety, muscle semi-synthetic opioids such as hydrocodone and bone pain, insomnia, vomiting or diarrhea. and oxycodone, and synthetic opioids such as Withdrawal symptoms occur when the amount fentanyl and methadone. of opioids used decreases or stops. Opioids are often used medically to relieve moderate to severe pain, but can also be used How Did We Get To A U.S. for other conditions -- for example, to suppress Opioid Epidemic? cough, to treat diarrhea and even to treat Opioid overdoses - including prescription opioids opioid use disorder. Opioids are very effective and heroin - kill 78 people daily. This number has for treating severe pain such as that associated quadrupled since 1999. In 2015 alone, opioids with cancer, post-surgery, or accident-related were involved in over 28,470 deaths. injuries. While opioids provide pain relief, they Despite the staggering statistic, the number also cause physical dependence, respiratory of prescriptions written for opioid analgesics depression, euphoria, reduced intestinal motility continues to increase. and other desired and undesired effects. Since these pharmacologic effects focus on blocking Misuse of prescription opioids, and heroin use, pain, opioids have high potential for misuse. are also on the rise. In 2015, approximately 12.5 million Americans reported misusing pain Opioid drugs mimic the body’s natural relievers in the previous year and approximately response to pain by stimulating the body’s 914,000 Americans reported use of heroin. ©2016 Georgia Prevention Project - All Rights Reserved. 4
EXECUTIVE Prescription Opioids and Heroin Epidemic in Georgia SUMMARY And, the costs of this epidemic of prescription prescribing of prescription opioids (e.g., PDMPs) opioid overdose and misuse are high, estimated may be a driver of increased deaths from heroin at $78.5 billion in 2013 alone. overdose, there is little empirical evidence of a causal link. Who Is At Greatest Risk? Instead, the evidence suggests that market The highest rates of prescription opioid forces such as increased availability, reduced overdose deaths from 1999 to 2014 were price and increased purity of heroin could be among non-Hispanic whites and American more important drivers of increased heroin use Indian or Alaskan Natives, persons aged 25 to and heroin overdose deaths. 54, and men. Rates of prescription overdose deaths are on the rise for women (Centers for What Is The Impact Of Opioid Use Disease Control, CDC, 2016). Risk factors for In Georgia? prescription opioid misuse and overdose include doctor shopping (i.e., receiving overlapping Similar to national trends, deaths related to prescriptions from multiple providers and opioid overdose continue to rise in Georgia. pharmacies), taking high daily doses of Recent data from the Georgia Department of prescription pain relieves, having mental illness Public Health indicate that deaths related to or a history of substance misuse, being low- drug overdose are now almost equal to deaths income, and living in a rural area (CDC, 2016). due to motor vehicle crashes (Figure 1). According to Centers for Disease Control and Opioids, primarily prescription pain relievers and Prevention, people at highest risk for heroin heroin, are the main driver of drug overdose addiction are those addicted to prescription deaths. Of the 1,307 drug overdose deaths in opioid painkillers, cocaine, marijuana and 2015 in Georgia, 900 or 68 percent were due alcohol; people 18 to 25 years of age living in to opioid overdoses including heroin (Figure 2). large metropolitan areas, and people without Further, a statistically significant increase in the insurance or enrolled in Medicaid. drug overdose death rate occurred from 2013 to 2014, and overdose deaths tripled between What Is The Relationship Between 1999 and 2013 in Georgia. Non-Medical Use Of Prescription Prescription opioid overdose deaths in Georgia Opioids And Heroin Use? increased tenfold to 549 deaths, or a rate of 5.5 Several descriptive and observational studies per 100,000 age-adjusted deaths, between 1999 suggest a link between non-medical use of and 2014. Georgia: Among top 11 states with prescription opioids and heroin, particularly the most prescription opioid overdose deaths among people with frequent nonmedical use or (Figure 3). people with prescription-opioid use disorder. Recent data indicate that 55 of Georgia’s 159 Two recent national studies found that about counties had higher drug overdose rates 80 percent of heroin users reported using than the U.S. average in 2014. This marks a prescription opioids for non-medical reasons significant increase from 11 years ago, when just before beginning use of heroin. However, 26 Georgia counties exceeded the U.S. average. it is important to note that only a small Sixty percent of the 55 counties with drug percentage (less than 5 percent) of people overdose rates higher than the national average who use prescription opioids for non-medical in 2014 are located in rural areas with limited reasons begin using heroin. This small access to substance use disorder treatment percentage translates to several hundred and/or medication-assisted treatment. These thousand new heroin users per year and numbers suggest that two-thirds of all counties should not be minimized. in Georgia and 77 percent of rural counties While some argue that implementation of have limited or no access to an evidence-based policies to address misuse and inappropriate practice for opioid use disorder. ©2016 Georgia Prevention Project - All Rights Reserved. 5
EXECUTIVE Prescription Opioids and Heroin Epidemic in Georgia SUMMARY Figure 1: Deaths Related to Drug Overdose and Motor Vehicle Crashes, Georgia, 2001-2015 1,673 1,670 1,568 1,509 1,492 1,482 1,456 1,387 Source: 1,345 1,307 1,274 1,253 1,248 1,223 1,223 1,219 Georgia 1,177 1,125 1,070 1,059 1,074 Department 1,006 956 of Public 859 767 Health, 697 682 647 611 Office of 559 Health Indicators for 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 Planning, Drug Overdose Deaths Motor Vehicle Crash Deaths Death files. Figure 2: Number of Drug Overdose Deaths Related to Opioids including Heroin in Georgia, 2001-2015 1,274 1,307 1,074 1,070 1,059 1,125 1,006 956 859 900 767 795 647 697 682 Source: 611 600 622 633 606 559 554 Office of 467 Health 380 Indicators 265 277 294 243 246 242 for Planning 90 121 (OHIP), 3 2 3 1 6 20 16 3 25 31 48 1 5 Georgia Department 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 of Public All Drug Overdose Deaths Opioid Overdose Deaths, Including Heroin Heroin Overdose Deaths, Only Health. While prescription opioid deaths declined last year, users began shifting from prescription opioids to heroin. Hence, the spike in opioid deaths which include heroin. Figure 3: Number of Prescription Opioid Overdose Deaths in Georgia, 2001-2015 Source: Centers 588 549 for Disease Control and 498 488 464 Prevention 448 441 (CDC), National Center 362 for Health 348 308 Statistics. 270 Multiple Cause 221 of Death 171 186 1999-2014 on 152 CDC WONDER Online Database. Data 1 are from the Multiple Cause of Death Files, 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 1999-2015. ©2016 Georgia Prevention Project - All Rights Reserved. 6
EXECUTIVE Prescription Opioids and Heroin Epidemic in Georgia SUMMARY What Is The Cost Of Opioid Use And The Patient Protection and Affordable Care Misuse In Georgia And The U.S.? Act (ACA) of 2010 provides greater access to SUD treatment through major coverage The economic burden of prescription opioid expansions, regulatory changes requiring overdose, misuse and disorders in the U.S. is coverage of SUD treatments in existing estimated at $78.5 billion in 2013 with over one insurance plans, and requirements for SUD third of this amount coming from increased treatments to be offered on par with medical health care and substance use treatment and surgical procedures. The ACA enables costs ($28.9 billion). The health care costs states to address the opioid epidemic through associated with opioid misuse in Georgia four primary mechanisms: insurance coverage alone were estimated at $447 million in 2007 expansions, regulatory insurance reforms that with estimated per-capita costs at $44. Given require inclusion of SUD treatments, enhanced the increase in overdose deaths and misuse parity, and opportunities to integrate SUD of opioids in Georgia over 11 years, some treatment and mainstream healthcare. estimates indicate that health care costs associated with opioid misuse in Georgia have On July 22, 2016, President Obama signed increased by 80 percent since 2007. the Comprehensive Addiction and Recovery Act (CARA). This is the most comprehensive Hospitalizations related to opioid use and effort undertaken by Congress to address the misuse in Georgia also have skyrocketed, opioid epidemic. from about 302,000 in 2002 to about 520,000 in 2012. Similarly the cost of opioid related While it authorizes over $181 million each year inpatient care more than doubled during the in new funding to fight the opioid epidemic over same time period, rising to $15 billion in 2012. the next 10 years, monies must be distributed annually through the regular appropriations What Has Congress Done? process. CARA establishes a comprehensive, Three major pieces of federal legislation coordinated, and balanced strategy through addressed substance use disorders (SUD) in the enhanced grant programs that would expand past decade: prevention and education efforts, while also • Mental Health Parity and Equity promoting treatment and recovery. The bill Addictions Act of 2008 passed the U.S. Senate in March 2016, by a • Patient Protection and Affordable vote of 94-1. The bill passed the U.S. House of Care Act of 2010 Representatives in May 2016, by a vote of 400-5. • Comprehensive Addiction and CARA Six Pillars of Coordinated Response: Recovery Act of 2016. Solving the Opioid and Heroin Problem. The Mental Health Parity and Equity Addictions Act of 2008 requires private group Comprehensive health plans with 50 or more employees and Addiction and Recovery Act Medicaid managed care plans that cover SUD (CARA) treatment do so in a manner that is no more restrictive than coverage of other medical and Overdose Reversal Law Enforcement surgical procedures. Parity requirements have Criminal Justice Prevention not been extended to private plans in state Treatment Recovery Reform health insurance exchanges and Medicaid expansion plans. ©2016 Georgia Prevention Project - All Rights Reserved. 7
EXECUTIVE Prescription Opioids and Heroin Epidemic in Georgia SUMMARY Key Provisions of CARA • Expand prevention and educational efforts—particularly aimed at teens, parents and other caretakers, and aging populations—to prevent the use of methamphetamines, opioids and heroin, and to promote treatment and recovery • Expand the availability of naloxone to law enforcement agencies and other first responders to help in the reversal of overdoses to save lives • Expand resources to promptly identify and treat incarcerated individuals suffering from substance use disorders by collaborating with criminal justice stakeholders and by providing evidence-based treatment • Expand disposal sites for unwanted prescription medications to keep them out of the hands of our children and adolescents • Launch an evidence-based opioid and heroin treatment and intervention program to expand best practices throughout the country • Launch a medication assisted treatment (MAT) and intervention demonstration program • Strengthen prescription drug monitoring programs (PDMP) to help states monitor and track prescription drug diversion and to help at-risk individuals access services What should Georgia do? After a careful review of recent recommendations from the National Safety Council and the National Governors Association, SARA proposes a legislative agenda for Georgia as briefly outlined below. SARA provides detailed recommendations in the body of this study. In addition to the legislative agenda outline below, SARA recommends that the State conduct a comprehensive needs assessment specifically related to the opioid crisis and develop both a strategic plan and an implementation plan to guide the State’s response to this epidemic. Phase I – Georgia’s most urgent needs 1. Increase access to naloxone. More than 1,300 Georgians die each year from prescription opioid and heroin overdoses. Many of these deaths could be avoided with the use of naloxone, an opioid antagonist medication that reverses opioid overdose without significant negative side effects. First responders, parents, and educators should have easy access to naloxone and should have training in how to administer the drug. 2. Improve access to opioid use disorder treatment including medication-assisted treatment (MAT) and recovery support services. Anyone misusing prescription opioids or using heroin should have access to the full range of opioid use disorder treatment services including medically managed detoxification/withdrawal management, behavioral therapy, medications and recovery support services. These services should include support for 1) families who have members in recovery and 2) community organizations that focus on recovery. (continued next page) ©2016 Georgia Prevention Project - All Rights Reserved. 8
EXECUTIVE Prescription Opioids and Heroin Epidemic in Georgia SUMMARY 3. Increase funding for substance misuse prevention programs. The Georgia Legislature significantly reduced funding to DBHDD in 2010 for substance misuse prevention programs and administration. While DBHDD distributes and manages Federal substance misuse prevention funds, total State spending on substance misuse prevention within DBHDD currently is only $232,000 per year. Prescription drug education programs should target teens, young adults and parents. 4. Increase funding and improve mechanisms to address neonatal abstinence syndrome (NAS). Some hospitals in Georgia are overwhelmed with infants born with NAS. The problem is on the rise, and these hospitals need significant assistance in treating and managing the care of these infants. Moreover, health care providers need better education and training on how to deal with NAS. Our recommendations focus on three areas: 1) reducing incidence of NAS, 2) reducing NAS severity and optimizing health outcomes, and 3) leveraging resources and reducing costs of NAS. 5. Strengthen the Prescription Drug Monitoring Program (PDMP). While Georgia implemented important changes and enhancements to its PDMP during the 2016 legislative session, much work remains to be done. The PDMP helps track the writing and filling of prescriptions of controlled substances, particularly opioid-based painkillers. Phase II – Comprehensive and systematic approaches for Georgia 1. Increase oversight of pain clinics. Georgia passed the Pain Management Clinic Act in 2013. Consistent with the National Safety Council and the National Governor’s Association recommendations, Georgia should do two things: 1) require pain clinics to register with and use Georgia’s PDMP, and 2) conduct an evaluation of the legislation to determine if it is being enforced and what impact it has had on opioid prescribing and overdose deaths. 2. Create standards for prescriber education. The Georgia Composite Medical Board (CME) should mandate that a minimum of 5 hours of the 40 hours of required biannual credit hours focus specifically on the Georgia PDMP, pain management, and guidelines for prescribing opioid medications for chronic pain and/or substance use disorders. Longer term, Georgia should create a task force to address more detailed methods of educating all levels of health professionals on pain management and incorporating technology that integrates the PDMP more directly with patient electronic health records (EHR). 3. Create a recurring “blue-ribbon” commission on substance use and recovery. The Georgia Legislature, in collaboration with the Governor’s Office, should create a recurring commission that convenes every 5-7 years to establish strategy and statewide goals, recommend appropriations, and review progress on reducing substance misuse and expanding local systems of recovery supports and treatment services in Georgia. ©2016 Georgia Prevention Project - All Rights Reserved. 9
EXECUTIVE Prescription Opioids and Heroin Epidemic in Georgia SUMMARY The Georgia Prevention Project The Georgia Prevention Project - SARA’s host project ran more than 26,000 radio spots, organization - is a statewide not-for-profit effort placed 23,000 television ads, and placed more that focuses on reducing the use of dangerous than 588 billboards all over Georgia. This substances among teens and young adults. saturation effort significantly changed teens’ We accomplish our work through awareness perceptions of risk about the drug and produced campaigns, educational programming and results very similar to the Montana program. strategic partnerships with national and Riding the momentum of the successful “Not community based organizations. Even Once” Meth prevention campaign, the The Georgia Prevention Project evolved from Georgia Prevention Project launched in 2014 the Georgia Meth Project founded in 2009. capitalizing on the Meth Project techniques and Created by the Siebel Foundation, the national expanding its focus to include prescription drug Meth Project effort won more than 45 national misuse and heroin use. and international awards for its hard-hitting The Georgia Prevention Project partners with educational campaigns that helped reduce community members, schools and prevention first-time Meth use by more than 65 percent professionals to develop strategy, build coalitions in its first two years in Montana. Subsequent and provide drug education resources to bring launches in Idaho and Wyoming saw similar attention to the health and future of youth. results and led to the addition of Hawaii, Colorado and Georgia as part of the Meth Through its Teacher Substance Abuse Project family. Training Program, GPP has worked to ensure that large numbers of Georgia teens gain In Georgia, the campaign led to significant in-depth knowledge of the risks associated changes in teens’ perceptions of risk associated with the misuse of prescription drugs and with Meth. During the media portion of the the misuse of dangerous substances such as campaign of 2010-2012, the Georgia Meth methamphetamine and heroin. For more information, or Jim Langford to discuss this Executive Executive Director, Georgia Prevention Project; Chair, SARA Summary, please contact us. 3715 Northside Parkway Suite 1-320 Atlanta, GA 30327 404-831-1959 Email: info@georgiapreventionproject.org; jlangford@georgiapreventionproject.org Web sites: www.georgiamethproject.org; www.georgiapreventionproject.org ©2016 Georgia Prevention Project - All Rights Reserved. 10
Prescription Opioids and Heroin Epidemic in Georgia - Findings and Policy Recommendations 2017 ©2016 Georgia Prevention Project - All Rights Reserved.
FINDINGS & POLICY Prescription Opioids and Heroin Epidemic in Georgia RECOMMENDATIONS I. Opioid Overview 1. What opioids are Opioids are a class of drugs that act on the a neurotransmitter used in the brain’s pleasure body’s opioid receptors including natural, semi- or reward system. When activated, dopamine synthetic and synthetic opioids. Natural opioids produces a pleasurable, often euphoric feeling, include drugs such as which contributes to opioid misuse, as people seek to repeat these sensations. • morphine, derived from the resin of the opium poppy Use of opioids for more than a short period • semi-synthetic opioids such as of time leads to tolerance, physical and hydrocodone and oxycodone psychological dependence. This means opioid users must take larger doses of opioids over • synthetic opioids such as fentanyl and time to achieve the same effect. Additionally, methadone opioid users must not stop taking these drugs Opioids are often used medically to relieve abruptly or they will experience withdrawal moderate to severe pain, but can also be symptoms such as: agitation, anxiety, muscle used for example, to suppress cough, treat and bone pain, insomnia, vomiting or diarrhea. diarrhea, and even treat opioid use disorder. Withdrawal symptoms occur when the amount Opioids are very effective for treating severe of opioids decrease or are stopped. pain such as that associated with cancer, post- “Substance use disorders are a chronic medical surgery or accident-related injuries. While illness characterized by clinically significant opioids provide pain relief, they also cause impairments in health, social function and physical dependence, respiratory depression, voluntary control over substance use (not a moral euphoria, reduced intestinal motility and other failing or character flaw).” - Surgeon General’s desired and undesired effects. Since these Report, Facing Addiction in America, 2016. pharmacologic effects focus on blocking pain, opioids have high potential for misuse. 3. The U.S. Opioid epidemic 2. How opioids affect the human body In 2015, overdose deaths associated with prescription and illicit opioids increased to Opioid drugs mimic the body’s natural 33,091, from 28,647 in 2014 (CDC), suggesting response to pain by stimulating the body’s that 90 people die daily on average in the opioid receptors, most prominently the Mu (μ) U.S. from opioid overdoses. Over the past receptors. Mu receptors account for most of 15 years, overdose deaths related to opioids the effects of opioids and are primarily located have reached epidemic proportions (Rudd et in the brain, spinal cord, peripheral nervous al., 2015). The rate of opioid-related overdose system, and intestinal tract. deaths has increased over 200% since 2000. By stimulating the Mu receptors, opioids reduce Between 2011 and 2015, deaths related to the perception of pain by slowing down and heroin more than tripled to 12,990 (National blocking pain signal transmission to the brain, Center for Health Statistics). while also triggering the release of dopamine, ©2016 Georgia Prevention Project - All Rights Reserved. 12
FINDINGS & POLICY Prescription Opioids and Heroin Epidemic in Georgia RECOMMENDATIONS Despite these staggering increases in deaths Studies show a shift in the demographics of related to opioid overdose, the number of heroin users in recent years. In the 1960s, prescriptions written for opioid analgesics those initiating heroin use were predominantly continues to increase (Volkow et al. 2014). young men from minority groups living in urban The number of written prescriptions for opioid areas. Now those initiating heroin use tend medications rose from 75.5 to 209.5 million over to be somewhat older (mean age of first use the past decade (National Institutes of Health, is 22.9 years compared to 16.5 years), more 2014). According to a recent report, sales of concentrated in rural and suburban areas, and opioid analgesics quadrupled from 1999 to 2010 white (Cicero et al., 2014). (Frenk et al., 2015). According to the CDC, people at highest Misuse of prescription opioids and heroin risk for heroin addiction are those addicted use is also on the rise. In 2015, approximately to prescription opioid painkillers, cocaine, 12.5 million Americans reported misusing marijuana and alcohol, people 18 to 25 years pain relievers in the previous year and 2.0 of age living in large metropolitan areas, million Americans had a pain reliever drug use and people without insurance or enrolled in disorder (SAMHSA, 2016). In the same year, Medicaid (CDC, 2016 http://www.cdc.gov/ approximately 914,000 Americans reported vitalsigns/heroin/). use of heroin and 519,000 Americans met 4. Relationship between nonmedical use of diagnostic criteria for a heroin use disorder prescription opioids and heroin use (SAMHSA, 2016). The cost of prescription opioid misuse is high, estimated at $78.5 billion Studies found that about 80% of heroin in 2013 alone (Florence et al., 2016). Also see users reported using prescription opioids for opioids deaths by type of opioid: heroin: 2014 nonmedical reasons before beginning use of chart (Kaiser Family Foundation) in Appendix. heroin (Jones, 2013; Muhuri et al. 2013). The highest rates of prescription opioid Overall, these studies suggest a link between overdose deaths from 1999 to 2014 were nonmedical use of prescription opioids and among non-Hispanic whites and American heroin, particularly among people with frequent Indian or Alaskan Natives, persons aged 25 to nonmedical use, or people with prescription- 54, and men. The rates of prescription opioid opioid use disorder. However, it is important overdose deaths are on the rise for women to note that only a small percentage (less than (CDC, 2016). 5% of people who use prescription opioids for nonmedical reasons) begin using heroin. This small percentage translates to several hundred Risk factors for prescription opioid thousand new heroin users per year and should misuse and overdose: not be minimized (Compton et al., 2016). • doctor shopping (i.e., receiving overlapping prescriptions from multiple While some argue that implementation of providers and pharmacies) policies to address misuse and inappropriate prescribing of prescription opioids (e.g., • taking high daily doses of prescription pain relievers PDMPs) could be a driver of increased deaths from heroin overdose, there is little empirical • having mental illness or a history of evidence of a causal link. Instead, the evidence substance abuse suggests that market forces such as increased • being low-income availability, reduced price and increased purity • living in a rural area of heroin could be more important drivers (CDC, 2016). of increased heroin use and heroin overdose deaths (Compton et al., 2016). See Appendix for opioids overdose deaths by Public health efforts to address either Type of Opioid: Heroin, 2014. Kaiser Family prescription opioids or heroin use must consider Foundation State Health Facts. interrelationships between prescription opioid ©2016 Georgia Prevention Project - All Rights Reserved. 13
FINDINGS & POLICY Prescription Opioids and Heroin Epidemic in Georgia RECOMMENDATIONS and heroin use and focus on a comprehensive 100,000 persons in the U.S. occurred during the approach that includes all levels of prevention same time period. (i.e., primary, secondary, and tertiary), with However, the rate of increase in opioid deaths emphasis on harm reduction approaches as a in Georgia was much higher than the rate of principal tertiary prevention strategy (Kolodny et increase of opioid deaths in the U.S. Sales of al., 2015). opioids also quadrupled in the U.S. between 5. Impact of opioid use 1999 and 2014. a. Overdose deaths in Georgia Similar to national trends, deaths related to opioid overdose continue to rise in Georgia. Opioid overdose death rates including heroin in Even more alarming, recent data from the Georgia increased significantly - from 0.6 to 5.5 Georgia Department of Public Health indicate per 100,000 persons between 1999 and 2014 - that deaths related to drug overdose surpassed while a comparable increase from 1.4 to 5.9 per deaths due to motor vehicle crashes in 2014. Figure 1: Deaths Related to Drug Overdose and Motor Vehicle Crashes, Georgia, 2001-2015 1,673 1,670 1,568 1,509 1,492 1,482 1,456 1,387 Source: 1,345 1,307 1,274 1,253 1,248 1,223 1,223 1,219 Georgia 1,177 1,125 1,070 1,059 1,074 Department 1,006 956 of Public 859 767 Health, 697 682 647 611 Office of 559 Health Indicators for 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 Planning, Drug Overdose Deaths Motor Vehicle Crash Deaths Death files. Opioids, primarily prescription pain relievers and Further, the state experienced a statistically heroin, are the main driver of drug overdose significant 10.2% increase in the overdose death deaths. Of the 1,307 overdose deaths in 2015 rate from 2013 to 2014 (CDC, 2016), and a tripling in Georgia, 900, or 88% were due to opioids. of overdose deaths between 1999 and 2013. Figure 2: Number of Drug Overdose Deaths Related to Opioids including Heroin in Georgia, 2001-2015 1,274 1,307 1,074 1,070 1,059 1,125 1,006 956 859 900 767 795 697 682 Source: 647 622 633 611 600 606 Office of 559 554 467 Health 380 Indicators 265 277 294 243 246 242 for Planning 90 121 (OHIP), 3 2 3 1 6 20 16 3 25 31 48 1 5 Georgia Department 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 of Public All Drug Overdose Deaths Opioid Overdose Deaths, Including Heroin Heroin Overdose Deaths, Only Health. ©2016 Georgia Prevention Project - All Rights Reserved. 14
FINDINGS & POLICY Prescription Opioids and Heroin Epidemic in Georgia RECOMMENDATIONS Prescription opioid overdose deaths also significantly increased in Georgia, according to the CDC WONDER Online Database (see Figure 6, retrieved from http://wonder.cdc.gov/mcd-icd10.html). Figure 3: Number of Prescription Opioid Overdose Deaths in Georgia, 2001-2015 Source: Centers 588 for Disease 549 Control and 498 488 Prevention 464 (CDC), National 448 441 Center 362 for Health 348 308 Statistics. 270 Multiple Cause of Death 221 186 1999-2014 on 171 152 CDC WONDER Online Database. Data are from the Multiple Cause of Death Files, 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 1999-2015. While 50 prescription opioid overdose deaths It is important to note that 60% of the 55 occurred in 1999, resulting in a rate of 0.6 per counties with overdose rates that were higher 100,000 age-adjusted deaths, the most recent than the national average in 2014 are located in available data show a tenfold increase to rural areas. 588 deaths, or a rate of 5.8 per 100,000 age- 6. Economic costs of opioid misuse in Georgia adjusted deaths, in 2014. and the United States The economic burden of prescription opioid This puts Georgia in the overdose, misuse and dependence in the U.S. top 11 states nationwide with the was estimated at $78.5 billion in 2013 with over most prescription opioid one third of this amount coming from increased healthcare and substance use treatment costs overdose deaths. ($28.9 billion) (Florence et al., 2016). The healthcare costs associated with opioid misuse b. How Georgia compares to other states and in Georgia alone were estimated at $447 million the nation in 2007 and the estimated per-capita costs were $44 in Georgia. While Georgia has a lower rate of all drug overdose deaths (11.9 per 100,000) compared to Given the increase in overdose deaths and the U.S. average (14.7 per 100,000) (CDC, 2016), use of opioids in Georgia since 2007, some 55 of the 159 counties in the state had higher experts have estimated a rise in those costs of rates than the U.S. average in 2014 (CDC/NCHS, at least as 80% since that time. Those same National Vital Statistics System, mortality data experts agree that the state needs to monitor (see http://www.cdc.gov/nchs/deaths.htm); and the escalation. Hospitalizations related to Health Indicators Warehouse (see http://www. opioid use and dependence in Georgia also healthindicators.gov/Indicators/Drug-poisoning- have skyrocketed from about 302,000 in 2002 deaths-per-100000_10016/Profile). to about 520,000 in 2012. Similarly, the cost of opioid related inpatient care more than doubled This marks a significant increase from 11 years during the same time period, rising to $15 billion ago, when just 26 counties in Georgia had overdose death rates that were higher than the in 2012. 3 U.S. average. ©2016 Georgia Prevention Project - All Rights Reserved. 15
FINDINGS & POLICY Prescription Opioids and Heroin Epidemic in Georgia RECOMMENDATIONS II. Key Georgia Issues 1. Overdose reversal Naloxone, available since 1971, is an allowing pharmacists to dispense naloxone, opioid antagonist used to reverse opioid and passing Good Samaritan legislation. overdose through intravenous, intranasal The National Safety Council and Governors (NARCAN® Nasal Spray), and intramuscular Association submitted recommendations in formulations. Intramuscular delivery is available 2016 for increasing access to naloxone (NSC, by syringe in various generic forms or by auto- 2016; NGA, 2016). See Appendix. injector (EVZIO®). Georgia’s Naloxone Legislation Naloxone is highly effective and safe and quickly House Bill 965, the Georgia 911 Medical (within a few minutes) restores breathing. It Amnesty Law, signed on April 24, 2014, binds to opioid receptors, blocking the effects expanded access to naloxone. The law of opioids and endorphins. Side effects include authorizes administration of naloxone by withdrawal symptoms in most cases; while they trained first responders (law enforcement, are uncomfortable, they are not life threatening. firefighters, EMS personnel) for overdose It produces no effect in persons who do reversal. Additionally, the law allows for not have opioids present. Naloxone is not medical professionals to write naloxone designated as a controlled substance and does prescriptions, in good faith, to those at risk of not produce tolerance. opioid-related overdose. Because the nature and concentration of the This law also allows for administration of opioid causing the overdose is unknown, naloxone by lay people to persons suspected of treatment may require multiple doses of experiencing an opioid overdose and provides naloxone depending on the severity of protection from arrest and prosecution for respiratory depression. Fentanyl (50 to people who call 911 seeking medical assistance 100 times more potent than morphine) or for those experiencing alcohol or other drug- Carfentanil (10,000 times more potent than related overdose. morphine) may unknowingly be present in other substances (e.g., heroin, cocaine, Ultimately this means that neither the marijuana, counterfeit benzodiazepines, etc.), caller nor victim can be arrested, charged, significantly increasing overdose risk due to or prosecuted for small amounts of drugs, high concentration of opioids in undetectable alcohol, or drug paraphernalia if the evidence quantities (e.g., size of a grain of salt or smaller) was obtained as a result of seeking medical and require more doses to reverse overdose. assistance. This is important because the timely administration of naloxone has been proven to States can increase access to naloxone through reverse the effects of opioids such as heroin a number of mechanisms including allowing and opioids including hydrocodone, oxycodone, naloxone to be prescribed with standing orders, methadone and others drugs. ©2016 Georgia Prevention Project - All Rights Reserved. 16
FINDINGS & POLICY Prescription Opioids and Heroin Epidemic in Georgia RECOMMENDATIONS Victims of opioid overdose who Georgia Overdose Prevention. GOP receive naloxone in time are less likely to die or (georgiaoverdoseprevention.org) is suffer long-term brain or tissue damage than a grassroots organization of parents, those who do not. Removing barriers to health- healthcare professionals, harm reduction seeking behavior is a crucial step in the fight advocates and friends of those who have against opioid related deaths. lost loved ones to accidental drug overdose. GOP formed to create and advocate for the Naloxone Availability in Georgia passage of the Georgia 911 Medical Amnesty Pharmacies. Naloxone is available from some Law described above. The GOP provides pharmacies in Georgia. Individuals can ask overdose reversal training and a simple for naloxone without bringing in their own message based on the belief that when one is prescription at pharmacies because of standing breathing, there is still hope: Don’t run, call 911. orders that allow dispensing to individuals who First Responders. The extent to which police meet specified criteria. Georgia residents may departments, fire departments, and emergency obtain Narcan without a prescription from medical services have naloxone available across Georgia pharmacies. the state is unknown. Not all police precincts Adapt Pharma, a manufacturer of naloxone, have naloxone, and precincts differ in the provides a naloxone prescription request form availability of naloxone to officers. Cost and the with a National Drug Code (NDC) number to shelf life of naloxone are concerns. facilitate filling the prescription by pharmacies. Medical settings. Naloxone availability or However, no centralized information exists on distribution from various types of medical which pharmacies in Georgia carry naloxone. settings is unknown. Autoinjectors have Individuals need to contact pharmacies directly been distributed free of charge from EVZIO® to find out whether the pharmacy carries it and donations to opioid treatment provider clinics. how to obtain it. Schools. Because overdose may occur in The Georgia Pharmacy Association participated schools, naloxone availability in schools is in Project DAN (Deaths Avoided by Naloxone) to receiving increasing attention. The National help make naloxone available to pharmacies and School Nurses Association sees naloxone first responders. Georgia Pharmacy Foundation availability in schools as an element of a partnered with Medical Association of Georgia school’s emergency and response plan for safe (MAG) Foundation’s Think About It campaign to and effective reversal of opioid pain reliever distribute naloxone to pharmacies in 13 northeast overdose. counties in 2015. This effort included working to encourage pharmacies to carry naloxone. Adapt Pharma is offering NARCAN free to schools around the country. The Clinton Community organizations that legally can hand Foundation’s Health Matters Initiative is a out naloxone (syringe kits or Narcan) are those partner in this effort. (http://www.drugfree. with a standing order prescription on file from a org/news-service/naloxone-offered-free-high- medical director, and a pharmacy through which schools-around-country/) Pennsylvania was to order the prescription. the first state to make naloxone available in all Two organizations meet these criteria – the public schools through this program (http:// Georgia Overdose Prevention and the Davis fox43.com/2016/02/01/heroin-overdose-drug- Direction Foundation. Naloxone kits are naloxone-to-be-provided-free-to-all-pa-public- distributed through the Atlanta Harm Reduction schools/). States, such as Vermont, Delaware, Coalition by the Georgia Prevention Project. Illinois, and New York have made naloxone Availability is supported by grant funding from available in schools. DBHDD and donations. Home. Naloxone availability at home provides for rapid overdose reversal. Overdose may occur not only from heroin use and non- prescription use of opioid medications, but ©2016 Georgia Prevention Project - All Rights Reserved. 17
FINDINGS & POLICY Prescription Opioids and Heroin Epidemic in Georgia RECOMMENDATIONS also from prescription use. Errors in use, does not directly address reducing opioid sharing of medications, and use according misuse. There is no evidence that availability to prescription may result in overdose. Co- of life saving overdose reversal medication prescribing of naloxone with opioid medication increases opioid overdose risk. can reduce overdose. (Coffin et al., 2016; 2. Awareness, availability, and training on use. https://www.drugabuse.gov/news-events/ Limited awareness about the potential for news-releases/2016/06/co-prescribing- overdose and the availability of overdose naloxone-in-primary-care-settings-may-reduce- reversal medication is a concern among er-visits). H.R. 3680 - Co-Prescribing to Reduce those who may encounter opioid overdose Overdoses Act of 2016 was passed by the U.S. but who have not been properly trained on House of Representatives in May 2016 and administration procedures. is under review by the Senate. https://www. congress.gov/bill/114th-congress/house- 3. Cost of medication and medication bill/3680/text expiration. Escalating Naloxone Cost 4. Limited data on reversals. The ability to track overdose reversals is limited to Naloxone costs have increased substantially documentation by first responders and over the past decade, particularly since 2014. emergency rooms. Information from Naloxone increased from $.92 per dose in 2005 multiple sources needs to be collected and to $15 - $17 per dose by one manufacturer validated in a single system. in 2014 and up to $41 per dose in 2015 by When naloxone is administered by another. Narcan costs $63 per single dose, but individuals without the involvement of sells at about half that cost to government first responders or medical services, no agencies, community organizations and those information on use is available. A system without insurance. for centralized data collection from entities The cost of Evzio auto-injectors is substantially that distribute naloxone would provide more higher, having jumped in price from $287.50 accurate information. in July 2014 to $375 in November 2015, with 5. Linkage to services following reversal. further increases in 2016 to $2,250 per single Successful overdose reversals without linkage dose. Since scrutiny of these prices increases, to services to reduce or prevent future manufacturers have responded with discounts overdose of the same individual is a concern. and rebates. ADAPT makes Narcan available First responders report multiple reversals free of charge to schools and has donated on the same individual. Furthermore, 50,000 doses, and Kaleo has donated 150,000 subsequent overdoses may lead to autoinjectors to first responders and nonprofits. death because intervention with reversal Most insurance covers naloxone including medication did not occur in time. Evidence- Medicaid, and EVZIO promotes a zero based, effective systems are needed to link co-pay option. individuals experiencing an overdose reversal to services preferably via assertive case Naloxone Concerns management and warm hand-offs. Although Georgia has made progress in this At present, Georgia Department of Behavioral area, additional efforts to increase access to Health and Developmental Disabilities (DBHDD) naloxone are needed. General concerns about is developing business-card size materials to naloxone fall into the five areas: outline below. distribute. More effective measures for reducing 1. Possible perception as safety net for risk repeat overdose are needed, such as creating opioid use. Some groups and individuals linkage directly between individuals who can are concerned that availability of overdose provide direct, culturally congruent support and reversal medication may be perceived ongoing recovery services. These efforts have as a safety net by opioid users at risk of been put in place in other communities, and overdose, and that naloxone availability need exploration for their use in Georgia. ©2016 Georgia Prevention Project - All Rights Reserved. 18
FINDINGS & POLICY Prescription Opioids and Heroin Epidemic in Georgia RECOMMENDATIONS 2. Medication assisted treatment & recovery SARA Makes the Following support services Recommendations Regarding To meet the needs of patients with OUD, it is Medications important for patients to have access to the full 1. Increase awareness about overdose and range of SUD treatment services including: overdose reversal medication. • outpatient treatment 2. Increase access to naloxone and training • intensive outpatient treatment on use of the medication. • residential treatment 3. Develop a plan to address naloxone cost. • detoxification 4. Implement information technology • medications systems to improve tracking of • recovery support services naloxone use. (ASAM, 2016). 5. Establish immediate linkages to recovery services following overdose reversal to According to a National Safety Council report, Georgia does not meet the indicator for • reduce the potential for repeat “meets need for OUD treatment”, measured by overdose, and sufficient buprenorphine treatment capacity. • increase the likelihood of sustained Ongoing treatment and recovery support of recovery individuals affected by opioid use disorders 6. Mandate Insurance Coverage for involves addressing physical dependence Opioid Overdose-Reversal Medication: (including overdose risk) and the behavioral Naloxone revives an individual from a and psychosocial skills required for managing heroin or other opioid overdose and has recovery. Treatment decisions could depend saved thousands of Georgians’ lives. upon a range of factors including substance use history (e.g., duration, substances used, It has no psychoactive effects and prior recovery efforts), co-occurring disorders, concomitantly, no misuse potential. treatment availability, cost/payment options, To expand access to this life-saving family support, and legal requirements. medication, the new legislation requires Behavioral counseling, a key component of insurance companies to cover the costs Georgia’s recovery-oriented systems of care for of naloxone when prescribed to a person opioid addiction, generally follows the National who is addicted to opioids and/or to Institute on Drug Abuse (NIDA)’s Principles his/her family member/s on the same of drug addiction treatment: A research- insurance plan. based guide (2012; 3rd edition: drugabuse. gov/publications/principles-drug-addiction- treatment/evidence-based-approaches-to-drug- addiction-treatment/behavioral-therapies). How Georgia’s public behavioral health treatment system is managed currently The Department of Behavioral Health and Developmental Disabilities’ mission is to lead an accountable and effective continuum of care to support Georgians with behavioral health challenges, and intellectual and developmental disabilities in a dynamic healthcare environment. State funds and federal ©2016 Georgia Prevention Project - All Rights Reserved. 19
FINDINGS & POLICY Prescription Opioids and Heroin Epidemic in Georgia RECOMMENDATIONS block grants support a network of six regional opioid detoxification services and medication offices that administer each region’s hospital extremely limited in Georgia. and community resources. (Community Medications to manage withdrawal services are provided through contracts with symptoms during detoxification from private, for-profit, non-profit, and quasi-public opioids include methadone, buprenorphine agencies under contract with DBHDD through alone or with naloxone (Suboxone®), milder the regional offices. Services focus on addictive opioids, and clonidine. The length of the diseases, behavioral health, behavioral health detoxification process varies by individual prevention and other services. factors and goals. It may include use of Key Terms and Implications multiple medications concurrently or sequentially. Individual differences may Medication-assisted Treatment (MAT) include level of tolerance, substances used, Medication-assisted treatment (MAT) refers length of use, and medical complications. to multi-faceted individualized substance use In addition to becoming opioid free, goals disorder treatment models that employ both may include transition to methadone, medications and other services and supports for buprenorphine, or extended-release injectable recovery maintenance. naltrexone, each of which may affect length of The Georgia Department of Behavioral Health time required. Transition to extended-release and Developmental Disabilities (DBHDD) injectable naltrexone requires a 7-10 day opioid recognizes that MAT provides specific free period to avoid precipitating withdrawal. interventions for reducing and/or eliminating the Gaps in medication may make an individual use of illicit opioids and other drugs of misuse; vulnerable to using substances in their while developing the individual’s social support recovery process. Establishing systems for the network and necessary lifestyle changes; most effective implementation of treatment psychoeducational skills; pre-vocational skills protocols can lessen these vulnerabilities and leading to work activity (by reducing substance provide greater supports for recovery. use as a barrier to employment); social and interpersonal skills; improved family functioning; Management of tapers or transitions the understanding of addictive disease; and from the opioid agonists, methadone or the continued commitment to a recovery and buprenorphine, to extended-release injectable maintenance program. naltrexone could be affected by approved usage of transitional medications. Medically Managed Detoxification/Withdrawal Management Reduction in use of methadone and buprenorphine requires a long taper. The Opioid withdrawal, whether from prescription length of the taper can be reduced with use of medication or heroin, often produces extreme alternative medications, such as milder opioids, and extended discomfort. Symptoms include: which may not be approved for opioid tolerance sweating, shaking, chills, body aches, yawning, management. Longer tapers increase cost and large pupils, headache, drug craving, nausea, impact the viability of transitioning clients. vomiting, abdominal cramping, diarrhea, inability to sleep, confusion, agitation, Access to medically managed detoxification for depression, anxiety, … and other behavioral opioids and other substances differs broadly changes, and can last for days and weeks. across the country, from no availability to Fear of withdrawal symptoms is a significant free walk-in 24/7, for anyone, regardless of deterrent to discontinuing opioid use, and a insurance status. frequent reason for relapse. Outpatient and inpatient options might be Because opioid withdrawal is not considered appropriate for opioid detoxification. Insurance life threatening, detoxification is generally not coverage restrictions, as well as lack of available covered by Medicaid and private insurance, beds or outpatient services, limit access to making access to inpatient or outpatient detoxification for many individuals ready to ©2016 Georgia Prevention Project - All Rights Reserved. 20
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