PHD PROGRAM IN CLINICAL AND MOLECULAR MEDICINE XXXVII CYCLE ACADEMIC YEAR 2021/2022

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Università degli Studi di Perugia
Dipartimento di Medicina e Chirurgia
Piazza Lucio Severi 1/8 - 06132 Perugia

         PhD Program in Clinical and Molecular Medicine
                          XXXVII Cycle
                   Academic Year 2021/2022
                                     under accreditation process

    •   1. Brief presentation of the doctorate
    •   2. Available Curricula
    •   3. General aims
    •   4. Training program
    •   5. Educational activities in iter training
    •   6. Description of the training activities
    •   7. Verification of educational obligations
    •   8. Career opportunities
    •   9. Disciplinary and interdisciplinary didactic activity
    •   10. Activities of PhD students
    •   11. Operational and scientific structures
    •   12. Members of the Academic Board
    •   13. International collaborations
    •   14. Admission requirements
    •   15. Admission procedures

Contacts:

Coordinator:
Prof. Cristina Mecucci MD, PhD
Section of Hematology, University of Perugia, Department of Medicine and Surgery
Ph. +39 075-5783808/3289
Fax. +39 075-5783691
e-mail: cristina.mecucci@unipg.it

For information:
Doctoral Office, University of Perugia
Tel. 075 585 6692 – 075 585 6687
e-mail: ufficio.dottorati@unipg.it
1. Brief presentation of the doctorate:

The PhD in Clinical and Molecular Medicine is established at the Department of Medicine and
Surgery of the University of Perugia. It lasts three years. The doctorate provides five training
curricula: Pathology and Clinical Studies of Atherosclerosis and Aging; Neurosciences; Surgical
Sciences; Biotechnologies in Human Bone Marrow Transplantation; Radiotherapy in Oncology.

The aim of the PhD course is training for high quality researchers in order to improve their
scientific knowledge and research autonomy in diseases with a high social impact which occupy
the first places for diffusion and cause of death. The PhD program is providing skills in strategic
research areas at a European level for the prevention of cardiovascular diseases, the development
of neuroscience, the application and development of innovative surgical methodologies, and the
precise diagnosis and innovative treatments of leukemias. The PhD students are stimulated to
become protagonists themselves. They may propose and conduct scientific research after careful
examination of international literature.

Job opportunities for PhDs in this fields are likely increasing in public or private research
institutions.

Career opportunities can be found in academia, health services, private research centers and
national and international pharmaceutical industries. Calls for temporary or permanent positions
published by scientific associations, scientific journals, pharmaceutical industries and universities
are regularly announced to PhD students. The implementation of a system for monitoring the
career opportunities of doctoral students is being planned.

2. Curricula available

1. "Pathology and Clinical Studies of Atherosclerosis and Aging", includes the study of lipid
metabolism, methods for the study of hepatic steatosis and research on the regulation and
modulation of immune-mediated IDO tolerance (indolamine 2,3 dioxygenase-1) in plasma and
adipose tissue of people with obesity, sepsis and inflammation;

2. "Neurosciences", aims at improving the knowledge of the pathogenetic mechanisms and
preclinical aspects of neurodegenerative, vascular, inflammatory diseases of the nervous system,
underlying headache and epilepsy as well as aspects concerning the transmission and synaptic
plasticity both physiological and in experimental models of diseases with particular regard to
neurodegenerative diseases;

3. “Surgical Sciences", is dedicated to improving the surgical methodology of experimental
research, particular in oncology, with potential application and translation in the clinical setting,
and the development of new diagnostic tools and therapeutic strategies applied to diseases of
different organs or systems ( stomach and intestines, respiratory and urinary tracts, ear, nose and
throat);

4. "Biotechnologies in Bone Marrow Transplantation”, Perugia is an internationally recognized
Centre in haplo-identical transplantation. The Course aims at genome analysis and at the use of
monoclonal antibodies in precision diagnosis and personalized therapy, including cell therapy and
CAR-T cells. Animal models are applied to study leukemia origin and immunological reconstitution
post-transplant.
5. “Radiotherapy in Oncology”, integration of radiotherapy with biomolecular markers and new
treatments. Development of radiomics tools to predict the response to radiation treatments.
Clinical research in the use of special radiotherapy techniques.

The coordinator, Prof. Cristina Mecucci, is one of the main worldwide experts in cytogenetics and
molecular genetics of tumors. She has produced more than 350 publications on preclinical and
clinical aspects which significantly contributed to diagnostic and prognostic classifications of
leukemias and lymphomas.

The Academic Board includes 47 researchers and professors, of whom 37 belonging to the Perugia
University, with consolidated experience in the doctoral curricula.

The research doctorate benefits from the collaboration of numerous international research
Institutes in which doctoral students are hosted to improve their training and to develop shared
research projects. The doctorate also avails himself of the support of European consortia (Marie
Curie 2020-2023). During the PhD program, stays abroad are foreseen for all students.

DESCRIPTION AND AIMS OF THE COURSE

3. General aims

The general aim of the Doctoral Course in Clinical and Molecular Medicine is to provide PhD
students with a thorough theoretical and practical preparation in different aspects of basic and
preclinical, and clinical research.

Basic research is mainly focused at discovering the pathogenetic mechanisms of diseases.
Preclinical research aims to transfer the results of basic research into clinical work. Clinical
research is enriched by promotion and participation to multicentric studies and clinical trials,
including fase 1 studies.

Research activities can be described as follows:

1) investigations on the biology of human disorders to provide the scientific basis for the
development or improvement of new therapies;

2) pre-clinical or animal model studies conducted with the aim of improving knowledge on
pathogenesis and therapies;

3) basic scientific studies defining the biological effects of treatments in humans;

4) studies aimed at allowing adequate development of a treatment and of its clinical use.

This applies both to medical and surgical disciplines.

4. Training program

The course is divided into five curricula and a progression of theoretical and practical learning is
distributed over the three years of the course, which also includes a staying abroad.
The first year is dedicated to theoretical knowledge and basic experimental laboratory / surgical
techniques, through a program of lectures, seminars, journal clubs, and attendance at the
laboratories and surgical theater under tutoring. Lectures include formal teachings, seminar
cycles, webinars, journal clubs.

•   Pathology and Clinical Studies of Atherosclerosis and Aging: pathophysiological basis of lipid
    and glycidic metabolism. Identification and use of laboratory markers.

•   Neurosciences: introduction to the pathogenetic models of neurodegenerative diseases.
    Approaches to laboratory experimentation in biomarker evaluations.

•   Surgical Sciences: principles of surgery in oncology and hematology. Applications in the
    diagnostic and therapeutic field.

•   Biotechnologies in Human Bone Marrow Transplantation: training on genome methodologies:
    conventional cytogenetics - FISH - Next Generation Sequencing - use and interpretations.
    Target terapy: current principles and application.

• Radiotherapy in Oncology: principles of radiobiology; integration between systemic therapies
  and radiotherapy in onco-hematology; radiotherapy equipment and techniques

Common fields: enhancement and management of research. English and scientific writing.
Computer technology. Bioinformatics. Laboratory approaches for molecular medicine. Animal
models. Emerging infections: Coronavirus - clinical impact and experimental models.

The second year is aimed at the development of research projects through an intense research
and laboratory activity by a continuous updating of the topics of interest through the study of
literature, participation in congresses and participation in teaching and training of students.

• Pathology and Clinical Studies of Atherosclerosis and Aging: hepatic steatosis, classification,
  etiopathogenesis and animal models. Inflammation, inflammasome and immunity.

• Neurosciences: diagnostic framework of neurodegenerative diseases. Pre-clinical and animal
  models for the study of headache and epilepsy.

• Surgical Sciences: thoracic surgery in solid tumors, surgery in malignant haemopathies. Invasive
  methods for diagnosis in oncology.

• Biotechnology in Human Bone Marrow Transplantation: hematopoietic stem cells:
  identification, separation, enrichment. CAR-T cells: principles, production and technologies of
  genetic engineering.

• Radiotherapy in Oncology: stereotaxic radiotherapy; radiotherapy in conditioning for
  hematopoietic stem cell transplantation (Total Body Irradiation and Total Marrow / Lymphoid
  Irradiation); radiotherapy as a bridge treatment in patients who will receive CAR T therapy

The third year includes the preparation of the final experimental thesis, in addition to research
and continuous updating related to the individual research project of each student,
• Pathology and Clinical Studies of Atherosclerosis and Aging: Innate immunity and tolerance.
   Immuno-modulatory mechanisms of IDO. The role in obesity, sepsis and inflammatory
   processes.

 • Neurosciences: biomarkers of neurodegenerative diseases. Cerebrospinal fluid biomarkers.
   Introduction of new laboratory methods.

 • Surgical Sciences: surgical techniques and biomarkers in oncology.

 • Biotechnology in Human Bone Marrow Transplantation: mono-clonal antibodies; production
   methods and application tests. Extensive use of mono-clonal antibodies: from diagnosis to
   therapy.

 • Radiotherapy in Oncology: clinical, dosimetric and biomolecular parameters predicting
   outcome in patients treated with Total Marrow / Lymphoid Irradiation; quantitative analysis of
   data extracted from diagnostic imaging methods for the development of predictive outcome
   models in patients undergoing radiation treatment; translational research on the role of the
   microbiota in radiotherapy.

 Lessons for the academic year 2021-2022 are planned at CREO, Hemato-Oncological Research
 Center, Aula Rita Levi Montalcini, Piazzale G. Menghini, 9, 06132 Perugia. Alternatively online
 lectures will use The Teams platform through the University of Perugia facilities.

 The dates and times will be updated on the site and emailed to students and faculty.

 5. Educational activity iter training

      Calendar                                Description                          HOURS   ECTS

                      COVID19. First Module.                                        12      2
                      Clinical and Molecular Medicine facing a new challenge.
                      Speaker:
                      Prof. Antonella Mencacci
           2021       University of Perugia
November   2022
           2023       COVID19. Second Module.                                       12      2
                      Clinical impact in affected and unaffected patients.
                      Speakers:
                      Prof. Patrizia Mecocci
                      Prof. Alfonso Tortorella
                      University of Perugia

                      Pathophysiology of neoplastic diseases and molecular          12      3
            2022      diagnosis.
January     2023      Speakers:
            2024      Prof. Cristina Mecucci
                      Prof. Enrico Tiacci
                      Prof. Giovanni Cochetti
                      University of Perugia

                      Pathophysiology of neoplastic diseases and target therapy.    12      3
                      Speakers:
            2022      Prof. Maria Paola Martelli
Calendar                                Description                            HOURS             ECTS

February       2023   Prof. Paolo Sportoletti
               2024   Prof. Cynthia Aristei
                      University of Perugia

                      Biomarkers: definition, identification and validation.             12               3
                      Speakers:
               2022   Prof. Lucilla Parnetti
March          2023   Prof. Matteo Pirro
               2024   Prof. Ettore Mearini
                      Prof. Lucio Cagini
                      University of Perugia

                      The multiple faces of immunology in the pathophysiology of         12               3
               2022   neoplastic and non-neoplastic diseases.
April          2023   Speakers:
               2024   Prof. Massimiliano Di Filippo
                      Prof. Luca Stingeni
                      Prof. Guido Bellezza
                      University of Perugia

                       “Target” Surgery                                                  12               2
               2022   Speakers:
May            2023   Prof. Francesco Puma
               2024   Prof. Lucio Cagini
                      University of Perugia

               2022   Cell Therapy                                                       12               3
June           2023   Speaker:
               2024   Prof. Cristina Mecucci
                      Prof. Enrico Tiacci
                      University of Perugia

                                                                                         12               3
                      Pathophysiological bases of targeted therapies in non -
               2022   neoplastic pathologies
July           2023   Speakers:
               2024   Prof. Paola Sarchielli
                      Prof. Carmelinda Ruggiero
                      Prof. Gabrio Bassotti
                      Prof. Matteo Pirro
                      Prof. Alessandro Tozzi
                      University of Perugia

 Topics may undergo updates and even variations in step with scientific discoveries and
 international literature relating to the curriculum of the Course.

 6. Description of the training activities
               Type                                                Description

 Linguistics               Participation at foreign language courses held at the University Language Center (CLA).
                           The level of language courses offered at the CLA refer to the Common European
                           Framework of Reference (CEFR). Language courses can last six months (10 ECTS) or one
                           year (13 ECTS). At the end of the course, the level achieved in the individual language
                           skills will be assessed.
Type                                                    Description

Informatics                    Possibility to participate in computer laboratories already offered in other University
                               courses. Specific courses will also be organized in modules of 1 ECTS (use of software for
                               data analysis, word processing programs, programs for archiving and importing
                               bibliographic data; in-depth study of databases and their consultation). For these
                               courses, a verification of the level of knowledge acquired will be provided.

Management of research,        Possibility to participate in 1 ECTS courses on research management, knowledge of
knowledge of research          research systems and funding systems. The courses will deal in particular with: research
systems and funding            design and development techniques; drafting and management of financial plans for
systems                        research projects; project management by stages of work progress and their reporting;
                               management of relations with sponsors. The courses include a final exam.

Enhancement of research        The PhD course offers the opportunity to participate in 6 courses of 1 ECTS on the
results and intellectual       enhancement of research and intellectual property. The 6 courses will deal with: the
property                       transition from basic research to applied research; research enhancement techniques;
                               funding of applied research; the protection of intellectual property; the intervention of
                               universities in favor of patents; business creation and research spin-offs. The courses
                               include a final exam.

Animal Models                  As part of the PhD course there are courses for the use of animal models at the
                               University with final exam.

Other active courses for all   - Biostatistics and Data Analysis;
curricula
                               - Scientific Writing Course with final exam;

 7. Verification of educational obligations
At the end of each year, PhD students are required to submit an individual annual report regarding
the research activity carried out and the results achieved, any participation in seminars,
congresses and other scientific initiatives, together with any publications produced. The progress
of the activities scheduled at the beginning of the year must emerge from the final report. The
coordinator will submit the reports to the Academic Board for approval by October 31 of each
year.

The Academic Board may at any time request an extraordinary verification of the activities carried
out by a PhD student and order the forfeiture of the course in the event of a negative judgment.

8. Career opportunities
The PhD in Clinical and Molecular Medicine represents a post-graduate advanced training course
on wide-ranging research topics with a high social impact concerning diseases that, in
epidemiological terms, occupy the first places in terms of diffusion, according to WHO
perspectives. Therefore, job opportunities in public or private research institutions are set to
increase. Career opportunities can be found in academia, in research centers and private
laboratories and in pharmaceutical industries, both national and international, and within the
national health service. Calls for temporary or permanent positions published by scientific
associations, scientific journals, pharmaceutical industries and universities will be made known to
PhDs. The implementation of a system for monitoring the career opportunities that the doctoral
students will be able to achieve is being planned.
9. Disciplinary and interdisciplinary didactic activity

                                            Tot ECTS:   n. teachings: 36                                with final exam: 36
   Ad hoc courses in the training process   72

   Mutual courses with master's degree      Yes         n.: 20                                          with final exam : 20
   curricula

                                            No
   Mutual courses with other degree
   courses (first level)

                                            Yes
   Seminars

   Research Opportunities                   Yes         Italy- outside the institutions involved        expected period (in months per
                                                        Abroad - inside the institutions involved       student): 12
                                                        Abroad - outside the institutions involved

   10. Activities of PhD students

   It is expected that PhD students can carry out tutoring activities of supplementary teaching
   activities for a maximum of 20 hours.

   11. Operational and scientific structures

                          Type                                                               Brief description

                                                        Molecular pathology haemopathies, cytogenetics and molecular genetics,
Equipment and / or Laboratories                         next generation sequencing (NGS), transplant immunology flow cytometry,
                                                        molecular biology, laser microscopy, GMP manipulating stem cells and other
                                                        cell populations, including CAR-T. Positive press chambers. Non-invasive
                                                        vascular diagnostics, functional / morphological macro / microcirculation,
                                                        echocardiography, lipid metabolism. Early diagnosis of neurodegenerative
                                                        diseases: Cerebrospinal fluid biomarkers dosage specific markers. Elekta
                                                        Brachytherapy, 2008.

Library            consistency in volumes and           Centralized Library Faculty of Medicine
heritage           coverage of the topics of the
                   course

                   Journal subscriptions (number,       Centralized Library Faculty of Medicine
                   years owned, coverage of the
                   course topics)

E-resources        Databases (access to the             University newspaper library
                   content of sets of journal and /
                   or editorial series)

                   Software specifically related to     Office (Excel, power point, word), SPSS, SAS, Fastqc, BWA-MEM, GATK,
                   the research areas provided          Bistmark, Botwie (1/2), STAR, TopHat, HTseq, Cutadapt, Trimmomatic,
                                                        Flexbar, Picard, Methclone, Hypergeometric Optimization of Motif
                                                        EnRichment (HOMER), SAMTools, BEDTools, MethylKit, Methylsig, EdgeR,
                                                        DESeq2, DexSeq, Limma, ChipEnrich, CEQer2, MuTect, Annovar, Varscan,
Type                                                            Brief description

                                                  LRpath, GSEA, ConsensusPathDB e Fusion Analyser. MIM Software Inc. for
                                                  multi-modal imaging management. Oncentra Brachy treatment planning
                                                  system by Elekta.

                Spaces and resources for PhD      n. 40 computer stations with related software
                students and for electronic
                computing

12. Members of the Academic Board:

Internal Members

 n.   Surname         Name           University   Department / Structure   Title                              Academic
                                                                                                          Recruitment Field

  1. PIRRO            Matteo         PERUGIA      MEDICINE AND SURGERY     Associate Professor           06/B1

  2. BELLEZZA         Guido          PERUGIA      MEDICINE AND SURGERY     Confirmed Researcher          06/A4

  3. MANNARINO        Massimo        PERUGIA      MEDICINE AND SURGERY     Confirmed Researcher          06/B1
                      Raffaele

  4. BISCARINI        Andrea         PERUGIA      MEDICINE AND SURGERY     Associate Professor           02/D1

  5. PARNETTI         Lucilla        PERUGIA      MEDICINE AND SURGERY     Associate Professor           06/D6

  6. SARCHIELLI       Paola          PERUGIA      MEDICINE AND SURGERY     Confirmed Researcher          06/D6

  7. COSTA            Cinzia         PERUGIA      MEDICINE AND SURGERY     Confirmed Researcher          06/D6

  8. DI FILIPPO       Massimiliano   PERUGIA      MEDICINE AND SURGERY     Associate Professor           06/D6

  9. PUMA             Francesco      PERUGIA      MEDICINE AND SURGERY     Full Professor                06/E1

 10. MEARINI          Ettore         PERUGIA      MEDICINE AND SURGERY     Full Professor                06/E2

 11. RICCI            Giampietro     PERUGIA      MEDICINE AND SURGERY     Associate Professor           06/F3

 12. SCIALPI          Michele        PERUGIA      MEDICINE AND SURGERY     Full Professor                06/I1

 13. ASCANI           Stefano        PERUGIA      MEDICINE AND SURGERY     Associate Professor           06/A4

 14. MECUCCI          Cristina       PERUGIA      MEDICINE AND SURGERY     Full Professor                06/D3

 15. MARTELLI         Maria Paola    PERUGIA      MEDICINE AND SURGERY     Associate Professor           06/D3

 16. ARISTEI          Cynthia        PERUGIA      MEDICINE AND SURGERY     Full Professor                06/I1

 17. BASSOTTI         Gabrio         PERUGIA      MEDICINE AND SURGERY     Associate Professor           06/D4

 18. CAGINI           Lucio          PERUGIA      MEDICINE AND SURGERY     Associate Professor           06/E1
n.   Surname        Name               University   Department / Structure   Title                                      Academic
                                                                                                                     Recruitment Field

 19. STINGENI        Luca               PERUGIA      MEDICINE AND SURGERY     Associate Professor                   06/D4

 20. BOSELLI         Carlo              PERUGIA      MEDICINE AND SURGERY     Confirmed Researcher                  06/C1

 21. MECOCCI         Patrizia           PERUGIA      MEDICINE AND SURGERY     Full Professor                        06/B1

 22. TOZZI           Alessandro         PERUGIA      MEDICINE AND SURGERY     Associate Professor                   05/D1

 23. MENCACCI        Antonella          PERUGIA      MEDICINE AND SURGERY     Full Professor                        06/A3

 24. RUGGIERO        Carmelinda         PERUGIA      MEDICINE AND SURGERY     Associate Professor                   06/B1

 25. TORTORELLA      Alfonso Antonio PERUGIA         MEDICINE AND SURGERY     Full Professor                        06/D5
                     Vincenzo

 26. HANSEL          Katharina          PERUGIA      MEDICINE AND SURGERY     Associate Professor                   06/D4

 27. RABALLO         Andrea             PERUGIA      MEDICINE AND SURGERY     Associate Professor                   06/D5

 28. SPORTOLETTI     Paolo              PERUGIA      MEDICINE AND SURGERY     Associate Professor                   06/N1

 29. TIACCI          Enrico             PERUGIA      MEDICINE AND SURGERY     Associate Professor                   06/D3

 30. COCHETTI        Giovanni           PERUGIA      MEDICINE AND SURGERY     Fixed-Term Researcher                 06/E2

 31. COSTARELLI      Danilo             PERUGIA      MATHEMATICS AND          Fixed-Term Researcher                 01/A3
                                                     COMPUTER SCIENCE

 32. PALUMBO         Isabella           PERUGIA      MEDICINE AND SURGERY     Confirmed Researcher                  06/I1

 33. FILIPPI         Andrea             PAVIA        CLINICAL-SURGICAL,       Full Professor “Straordinario”        06/I1
                     Riccardo                        DIAGNOSTIC AND
                                                     PEDIATRIC SCIENCES

 34. CIANETTI        Stefano            PERUGIA      MEDICINE AND SURGERY     Full Professor                        06/F1

 35. FIORE           Tito               PERUGIA      MEDICINE AND SURGERY     Confirmed Researcher                  06/F2

 36. LA STARZA       Roberta            PERUGIA      MEDICINE AND SURGERY     Confirmed Researcher                  06/D3

 37. VAUDO           Gaetano            PERUGIA      MEDICINE AND SURGERY     Associate Professor                   06/B1

External and Foreign Members

 n. Surname        Name           Ateneo/Ente di         Department / Structure       Title         SSD        CUN-VQR      Curriculum
                                  appartenenza                                                                 area         affiliation
                                                                                                               assigned

 1. BIERSMA        LIESBETH       MAASTRICHT             FAC. HEALTH, MEDICINE AND Professor        MED/36     06           RADIOTHERAPY IN
                                  UNIVERSITY             LIFE
                                                         SCIENCES,RADIOTHERAPIE
n. Surname       Name         Ateneo/Ente di             Department / Structure            Title        SSD      CUN-VQR      Curriculum
                                   appartenenza                                                                       area         affiliation
                                                                                                                      assigned

                                                                                                                                   ONCOLOGY

     2. COLLAMATI     FRANCESCO    Istituto Nazionale di Fisica INFN - Sezione di Roma          Researcher FIS/07     02           RADIOTHERAPY IN
                                   Nucleare                                                                                        ONCOLOGY

     3. COOLS         JAN          UNIVERSITY OF LEUVEN       CENTRE FOR HUMAN                  Professor    MED/15   06           BIOTECHNOLOGY IN
                                                              GENETICS                                                             BONE MARROW
                                                                                                                                   TRANSPLANTATION

     4. DAL CIN       PAOLA        HARVARD UNIVERSITY         DEPARTMENT OF                     Professor    MED/15   06           BIOTECHNOLOGY IN
                                   BOSTON                     PATHOLOGY                                                            BONE MARROW
                                                                                                                                   TRANSPLANTATION

     5. FIGUEROA      MARIA        UNIVERSITY OF MIAMI -      DEPARTMENT OF HUMAN               Professor    MED/15   06           BIOTECHNOLOGY IN
                                   MILLER SCHOOL OF           GENETICS/ SYLVESTER                                                  BONE MARROW
                                   MEDICINE                   COMPREHENSIVE CANCER                                                 TRANSPLANTATION
                                                              CENTER

     6. HUI           SUSANTA      UNIVERSITY OF              CITY OF HOPE NATIONAL             Professor    MED/36   06           RADIOTHERAPY IN
                                   MINNESOTA                  MED CENTER, DEP. OF                                                  ONCOLOGY
                                                              RADIATION ONCOLOGY

     7. LANCIA        ANDREA       Fondazione IRCCS           Radioterapia Oncologica           Researcher MED/36     06           RADIOTHERAPY IN
                                   Policlinico San Matteo                                                                          ONCOLOGY

     8. OFFERSEN      BIRGITTE     AARHUS                     DEPARTMENT OF CLINICAL            Professor    MED/36   06           RADIOTHERAPY IN
                                   UNIVERSITETSHOSPITAL       MEDICINE                                                             ONCOLOGY

     9. POORTMANS     PHILIP       UNIVERSITY OF              Department of                     Professor    MED/36   06           RADIOTHERAPY IN
                                   ANTWERP                    Radiotherapy                                                         ONCOLOGY

 10.    STEGMAIER      KIMBERLEY   HARVARD UNIVERSITY         DANA FARBER CANCER                Professor    MED/15   06           BIOTECHNOLOGY IN
                                   BOSTON                     INSTITUTE                                                            BONE MARROW
                                                                                                                                   TRANSPLANTATION

13. International collaborations:

Main universities and international research centers with which the college maintains research
collaborations:

n.                  Name              Country                                            Type of collaboration

1. NEUROCHEMISTRY, DEPT.              Sweden    Collaboration on projects aimed at the development of molecular markers for early diagnosis for
   CLINICAL NEUROSCIENCE,                       neurodegenerative diseases with dementia
   GOTEBORG

2. MOVEMENT DISORDER CENTRE,          Canada    Implementation and monitoring of deep brain stimulation methods in stereotaxic neurosurgery
   TORONTO WESTERN HOSPITAL,                    of Parkinson's disease
   UNIVERSITY OF TORONTO,
   ONTARIO

3. INSTITUTE FOR CANCER               USA       Use of whole genome sequencing, RNA sequencing, exome sequencing techniques in research on
   GENETICS, COLUMBIA                           lymphoproliferative diseases This approach has identified genetic alterations in orphan
   UNIVERSITY                                   pathologies, i.e. not characterized from a molecular point of view, new disease markers to aid in
n.            Name                Country                                         Type of collaboration

                                            the diagnosis and prognostic stratification of patients and that can represent targets of
                                            molecular therapies

4. DANA FARBER CANCER             USA       Use of Gene Expression-based High-Throughput Screening (GE-HTS) to identify small molecules
   INSTITUTE, HARVARD                       capable of modulating gene expression profiles (GEP) induced by the ectopic expression of
   UNIVERSITY, BOSTON                       transcription factors that unfortunately do not yet represent effective therapeutic targets. The
                                            GE-HTS approach studies the GEP of cell lines derived from acute leukemia in basal conditions
                                            and after the use of small molecules in order to identify a modulation action on deregulated
                                            pathhawys

5. AGING RESEARCH CENTER (ARC)    Sweden    Evaluation of risk factors and protective factors in brain aging and dementia related to nutrition,
   KAROLINSKA INSTITUTET,                   oxidative stress and inflammation (Kungholmen Project, Snac-K project in collaboration with
   STOCCOLMA                                Prof. Laura Fratiglioni; CAIDE and FINGER Projects in collaboration with Prof. Miia Kivipelto)

6. SYLVESTER COMPREHENSIVE        USA       Epigenetic mechanisms in the pathogenesis of the leukemic process; projects in collaboration
   CANCER CENTER, UNIVERSITY OF             with Prof. Maria E. Figueroa
   MIAMI MILLER SCHOOL OF
   MEDICINE

14. Admission requirements

All master's degrees obtained in Italy and equivalent, if obtained abroad, are able to apply for the
selection.

15. Admission procedures

Evaluation of CV.
Individual Research Project.
Oral Examination.
Language test.
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