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67 | 1 | 21 Gerontology International Journal of Experimental, Clinical, Behavioral and Technological Gerontology
The international Journal of Translational Research
on the Nervous System
The International Journal
o f Tr a n s l a t i o n a l R e s e a r c h
on the Nervous System
Editor-in-Chief
P.G. Unschuld, Zurich
Neurodegenerative Diseases is a bimonthly, multidisciplinary journal for Selected contributions
the publication of advances in the understanding of neurodegenerative • Education-Adjusted Normality Thresholds for FDG-PET in the Diagnosis
diseases, including Alzheimer’s disease, Parkinson’s disease, amyotropic of Alzheimer Disease: Mainta, I.C.; Trombella, S. (Geneva); Morbelli, S. (Genoa);
lateral sclerosis, Huntington’s disease and related neurological and psy- Frisoni, G.B.; Garibotto, V. (Geneva); Alzheimer Disease Neuroimaging
Initiative (ADNI)
chiatric disorders.
• Gene co-expression network analysis implicates microRNA processing in
Neurodegenerative Diseases accepts high-quality papers in the form of
Parkinson’s disease pathogenesis: Jason Chen (Los Angeles, CA)
either short reports (less than 5 pages) or articles (6–12 pages) from a • Phenotypic Variability in Autosomal Dominant Familial Alzheimer
broad spectrum of scientific research areas ranging from molecular and Disease due to the S170F Mutation of Presenilin-1: Tiedt, H.O.;
cell biology to neuroscience, pharmacology, genetics and clinical sci- Benjamin, B.; Niedeggen, M.; Lueschow, A. (Berlin)
ences. • Cognitive Reserve Hypothesis in Frontotemporal Dementia: Evidence
from a Brain SPECT Study in a Series of Greek Frontotemporal Dementia
Patients: Maiovis, P.; Ioannidis, P.; Gerasimou, G.; Gotzamani- Psarrakou, A.;
Karacostas, D. (Thessaloniki)
• Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients
Correlate with Tau but Not with Amyloid Pathology: An Immunohisto-
chemical Study: Merlini, M.; Kirabali, T.; Kulic, L.; Nitsch, R.M.; Ferretti, M.T.
(Zurich)
Neurodegenerative Diseases • Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and
Founded: 2004 hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis:
Category: Clinical Research/Basic Research Fifita, J.A.; Zhang, K.Y.; Galper, J.; Williams, K.L.; McCann, E.P.; Hogan, A.L.;
Fields of Interest: Neurology, Psychiatry, Gerontology/Geriatrics Saunders, N.; Bauer, D.; Tarr, I.S.; Pamphlett, R.; Nicholson, G.A.; Rowe, D.;
Yang, S.; Blair, I.P. (Sydney, NSW)
Listed in bibliographic services, including: • Patterns of Eye Movement Impairment Correlate with Regional Brain
PubMed/MEDLINE, Web of Science, Google Scholar, Atrophy in Neurodegenerative Parkinsonism: Vintonyak, O.; Gorges, M.;
Scopus, Embase Müller, H.-P.; Pinkhardt, E.H.; Ludolph, A.C. (Ulm); Huppertz, H.-J. (Zurich);
Kassubek, J. (Ulm)
2019: Volume 19 • Novel Blood Biomarkers Are Associated with White Matter Lesions in
6 issues per volume Fragile X-Associated Tremor/Ataxia Syndrome: Loesch, D.Z.;
Language: English Annesley, S.J.; Trost, N.; Bui, M.Q.; Lay, S.T.; Storey, E.; De Piazza, S.W.;
ISSN 1660–2854 Sanislav, O.; Francione, L.M.; Hammersley, E.M. (Melbourne, VIC);
e-ISSN1660–2862 Tassone, F. (Sacramento, CA); Francis, D.; Fisher, P.R. (Melbourne, VIC)
KF19080
Impact Factor: 2.785
More information at w w w. karger.com/nddOrgan of the International Association of Gerontology and Geriatrics (IAGG)
Gerontology
International Journal of Experimental, Clinical, Behavioral, Regenerative and
Technological Gerontology
Founded 1957 by F. Verzár as “Gerontologia”
Merged 1975 with “Gerontologia Clinica”, founded 1959 by E. Woodford-Williams and
A.N. Exton-Smith
Continued by F. Bourlière (1971–1983), H.P. von Hahn (1984–1990), M. Ermini (1991–1994),
W. Meier-Ruge (1995–2007), G. Wick (2008–2019)
Editor-in-Chief
Tamas Fülöp – University of Sherbrooke, Sherbrooke, QC, Canada
Managing Editor
G. Lepperdinger – Salzburg, Austria
Section Editors
Clinical Section
Christophe J. Büla – University of Lausanne Medical Center, Lausanne, Switzerland
Monika Lechleitner – A.ö. Landeskrankenhaus Hochzirl, Zirl, Austria
Peter Pietschmann – Medical University of Vienna, Vienna, Austria
Experimental Section
Andrzej Bartke – Southern Illinois University School of Medicine, Springfield, IL, USA
Björn Schumacher – University of Cologne, Cologne, Germany
Nektarios Tavernarakis – University of Crete, Heraklion, Greece
Jan Vijg – Albert Einstein College of Medicine, Bronx, NY, USA
Behavioral Science Section
Denis Gerstorf – Humboldt-University, Berlin, Germany
Julie D. Henry – University of Queensland, St. Lucia, QLD, Australia
Thomas M. Hess – North Carolina State University, Raleigh, NC, USA
Tim Windsor – Flinders University, Adelaide, SA, Australia
Regenerative Section
David M. Gardiner – University of California at Irvine, Irvine, CA, USA
Günter Lepperdinger – Universität Salzburg, Salzburg, Austria
(Continued on next page)
Printed in Germany on acid-free and non-aging paper
(ISO 9706) by Stückle Druck, Ettenheim(Continued)
Technological Section
Bijan Najafi – Baylor College of Medicine, Houston, TX, USA
Michael Schwenk – Universität Heidelberg, Heidelberg, Germany
Editorial Board
Clinical Section
Johannes Attems – Newcastle University, Newcastle upon Tyne, UK
Michael D. Beach – University of Pittsburgh School of Nursing, Pittsburgh, PA, USA
Joel Belmin – Sorbonne University, Paris, France
Martin Burtscher – Universität Innsbruck, Innsbruck, Austria
Giuseppe Del Giudice – Novartis Vaccines and Diagnostics, Siena, Italy
Vincent C. Emery – University of Senate, Guildford, UK
Jorge D. Erusalimsky – University of Wales, Cardiff, UK
Timothy W. Farrell – University of Utah, Salt Lake City, UT, USA
Luigi Fontana – The University of Sydney, Sydney, NSW, Australia
M. Eric Gershwin – University of California at Davis, Davis, CA, USA
Jorg Goronzy – Stanford University School of Medicine, Stanford, CA, USA
Urs Granacher – University of Postdam, Potsdam, Germany
Stefan Gravenstein – Brown University, Providence, RI, USA
Erin R. Hascup – SIU School of Medicine, Springfield, IL, USA
Klaus Hauer – Bethanien Krankenhaus, Heidelberg, Germany
Dae Hyun Kim – Harvard Medical School, Boston, MA, USA
Florian Kronenberg – Medizinische Universität Innsbruck, Innsbruck, Austria
Tom F. Lue – University of California at San Francisco, San Francisco, CA, USA
Andrea B. Maier – The University of Melbourne, Melbourne, VIC, Australia
S. Jay Olshansky – University of Illinois at Chicago, Chicago, IL, USA
Marwan N. Sabbagh – Cleveland Clinic, Las Vegas, NV, USA
René Schwendimann – Universität Basel, Basel, Switzerland
Klaus Seppi – Medizinische Universität Innsruck, Innsbruck, Austria
Thomas M. Stulnig – Medical University of Vienna, Vienna, Austria
Donald Craig Willcox – Okinawa International University, Ginowan, Japan
Experimental Section
Ai-Min Bao – Zhejiang University, Hangzhou, China
Holly M. Brown-Borg – University of North Dakota, Grand Forks, ND, USA
Collin Y. Ewald – ETH Zurich, Zurich, Switzerland
Björn Falkenburger – University Medical Centre Carl Gustav Carus, Dresden, Germany
Daniela Frasca – University of Miami, Miami, FL, USA
Leonid Gavrilov – NORC and the University of Chicago, Chicago, IL, USA
Efstathios S. Gonos – National Hellenic Research Foundation, Athens, Greece
Marcia C. Haigis – Harvard Medical School, Boston, MA, USA
Laura Haynes – University of Connecticut Health Center, Farmington, CT, USA
(Continued on next page)
© 2021 S. Karger AG, Basel
www.karger.com
karger@karger.com(Continued)
Susan E. Howlett – Dalhousie University, Halifax, NS, Canada
S. Michal Jazwinski – Tulane Center for Aging, New Orleans, LA, USA
Guido Kroemer – Inserm U848, Villejuif, France
Guang-Hui Liu – Chinese Academy of Sciences, Beijing, China
Antonello Lorenzini – University of Bologna, Bologna, Italy
Arnold Mitnitski – Dalhousie University, Halifax, NS, Canada
Alexey Moskalev – Komi Science Center of RAS, Syktyvkar, Russian Federation
Janko Nikolich-Zugich – University of Arizona College of Medicine, Tucson, AZ, USA
Wilson Savino – Oswaldo Cruz Institute, Rio de Janeiro, Brazil
Yaron Tomer – Albert Einstein College of Medicine, Bronx, NY, USA
Natascia Ventura – Heinrich Heine University, Düsseldorf, Germany
Andrus Viidik – Aarhus, Denmark
Georg Wick – Innsbruck Medical University, Biocenter,
Division for Experimental Pathology and Immunology, Innsbruck, Austria
Jacek M. Witkowski – Medical University of Gdańsk, Gdańsk, Poland
Johannes Zuber – Institute of Molecular Pathology, Vienna, Austria
Behavioral Science Section
Kaarin J. Anstey – University of New South Wales, Sydney, NSW, Australia
Kira S. Birditt – University of Michigan, Ann Arbor, MI, USA
Linda Clare – University of Exeter, Exeter, UK
Dale Dannefer – Case Western Reserve University, Cleveland, OH, USA
Xin-Qi Dong – Rutgers University, New Brunswick, NJ, USA
Katherine L. Fiori – Adelphi University, Garden City, NY, USA
Alan J. Gow – Heriot-Watt University, Edinburgh, UK
Daniel Grühn – North Carolina State University, Raleigh, NC, USA
Denise Park – University of Texas at Dallas Center for Brain Health, Dallas, TX, USA
Christina Röcke – University of Zurich, Zurich, Switzerland
Brent J. Small – University of South Florida, Tampa, FL, USA
Regenerative Section
James Adjaye – Heinrich Heine University, Düsseldorf, Germany
Ilaria Bellantuono – The University of Sheffield, Sheffield, UK
Umberto Galderisi – Università della Campania “Luigi Vanvitelli”, Naples, Italy
Johannes Grillari – University of Natural Resources and Life Sciences, Vienna, Austria
Heinrich Jasper – Genentech, Inc., South San Francisco, CA, USA
Kyung-Sun Kang – Seoul National University, Seoul, Republic of Korea
Armand Keating – Princess Margaret Hospital, Toronto, ON, Canada
James R. Mitchell – Harvard University, Boston, MA, USA
Patrick Vermette – University of Sherbrooke, Sherbrooke, QC, Canada
Qingbo Xu – King’s College London, London, UK
(Continued on next page)
© 2021 S. Karger AG, Basel
www.karger.com
karger@karger.com(Continued)
Technological Section
Sumi Helal – Lancaster University, Lancaster, UK
Jorunn L. Helbostad – Norwegian University of Science and Technology, Trondheim,
Norway
Hylton B. Menz – La Trobe University, Bundoora, VIC, Australia
Prudence Plummer – MGH Institute of Health Professions, Boston, MA, USA
Neil D. Reeves – Manchester Metropolitan University, Manchester, UK
Wolfgang Zagler – Vienna, Austria
Statistical Consultant
Christopher Ryne Estabrook – University of Illinois at Chicago, Chicago, IL, USA
Editor for the IAGG
Monica Rodriguez Perracini – City University of São Paulo, São Paulo, Brazil
© 2021 S. Karger AG, Basel
www.karger.com
karger@karger.comJournal Information
Aims and Scope
In view of the ever-increasing fraction of elderly people, understanding the mechanisms of
aging and age-related diseases has become a matter of urgent necessity. Gerontology, the
oldest journal in the field, is also the only journal that responds to this need by drawing
topical contributions from multiple disciplines to support the fundamental goals of extend-
Guidelines for Authors ing active life and enhancing its quality. The range of papers is classified into five sections.
We strongly encourage authors to read In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of age-related
the Guidelines for Authors at diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experi-
www.karger.com/ger_guidelines prior to mental Section contains up-to-date contributions from basic gerontological research. Pa-
submitting an article.
pers dealing with behavioural development and related topics are placed in the Behavioural
Science Section. Basic aspects of regeneration in different experimental biological systems
as well as in the context of medical applications are dealt with in the Regenerative Section
whereas the Technological Section contains important information on major technological
advances for the elderly. Providing a primary source of high-quality papers covering all as-
pects of aging in humans and animals, Gerontology serves as an ideal information tool for all
Journal Contact readers interested in the topic of aging from a broad perspective.
For questions or comments, please contact
the persons responsible who can be found at
http://www.karger.com/Journal/Contact/224091.
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karger@karger.comVol. 67, No. 1, 2021
Contents
Clinical Section: Research Articles
1 Comparison between Two Inspiratory Muscle Training Protocols, Low Loads
versus High Loads, in Institutionalized Elderly Women: A Double-Blind Randomized
Controlled Trial
Martin-Sanchez, C.; Barbero-Iglesias, F.J.; Amor-Esteban, V.; Martin-Nogueras, A.M. (Salamanca)
9 Efficacy of an Oxycodone-Propofol Combination versus a Fentanyl-Propofol
Combination in Conscious Sedation during Therapeutic Endoscopic Retrograde
Cholangiopancreatography in Elderly Patients
Guo, P.; Wu, H.; Liu, L.; Zhao, Q.; Jin, Z. (Wuhan)
17 Gait Disorder among Elderly People, Psychomotor Disadaptation Syndrome:
Post-Fall Syndrome, Risk Factors and Follow-Up – A Cohort Study of 70 Patients
Meyer, M. (Strasbourg); Constancias, F. (Zurich); Vogel, T.; Kaltenbach, G.; Schmitt, E. (Strasbourg)
25 The Effectiveness of an Active Learning Program in Promoting a Healthy Lifestyle
among Older Adults with Low Health Literacy: A Randomized Controlled Trial
Uemura, K. (Imizu); Yamada, M. (Tokyo); Okamoto, H. (Imizu)
36 Risk Factors and Long-Term Survival of Octogenarians and Nonagenarians
Undergoing Transvenous Lead Extraction Procedures
Jacheć, W. (Katowice); Polewczyk, A. (Kielce); Segreti, L.; Bongiorni, M.G. (Pisa); Kutarski, A. (Lublin)
49 Developing an Alternative Version of the Epworth Sleepiness Scale to Assess
Daytime Sleepiness in Adults with Physical or Mental Disabilities
Gronewold, J.; Lenuck, M.C.I.; Gülderen, I.; Scharf, A.-C. (Essen); Penzel, T. (Berlin); Johns, M.W.
(East Melbourne, VIC); Frohnhofen, H. (Witten); Hermann, D.M. (Essen)
60 The Association between Antidiabetic Agents and Leukocyte Telomere Length in
the Novel Classification of Type 2 Diabetes Mellitus
Huang, J.; Peng, X.; Dong, K.; Tao, J.; Yang, Y. (Wuhan)
69 Predictors of Frailty and Vitality in Older Adults Aged 75 years and Over:
Results from the Longitudinal Aging Study Amsterdam
de Breij, S.; van Hout, H.P.J. (Amsterdam); de Bruin, S.R. (Bilthoven); Schuster, N.A.; Deeg, D.J.H.;
Huisman, M.; Hoogendijk, E.O. (Amsterdam)
78 Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus
Disease Pneumonia in Elderly Patients: A Pivotal Study
Recinella, G.; Marasco, G.; Tufoni, M.; Brizi, M.; Evangelisti, E.; Maestri, L.; Fusconi, M.; Calogero, P.;
Magalotti, D.; Zoli, M. (Bologna)
87 Elevation of Urate in Saliva and Serum of Patients with Knee Osteoarthritis
Mirzaii-Dizgah, M.-R.; Mirzaii-Dizgah, M.-H.; Mirzaii-Dizgah, I. (Tehran)
Cover illustration
© S. Karger AG, 123rf.com
© 2021 S. Karger AG, Basel
Access to full text and tables of contents,
including tentative ones for forthcoming issues:
www.karger.com/gerExperimental Section: Systematic Analysis
91 The Role of Nrf2 in D-Galactose-Induced Cardiac Aging in Mice: Involvement of
Oxidative Stress
Yang, X.; Jia, J.; Ding, L.; Yu, Z.; Qu, C. (Nanjing)
Behavioral Science Section: Research Articles
101 Empathy and Coping: Older Adults’ Interpersonal Tensions and Mood throughout the
Day
Huo, M. (Davis, CA); Ng, Y.T. (Austin, TX); Birditt, K.S. (Ann Arbor, MI); Fingerman, K.L. (Austin, TX)
112 Event-Based but Not Time-Based Prospective Memory Is Related to Oral Health in
Late Adulthood
Manchery, N.; Nangle, M.R.; Grainger, S.A. (Brisbane, QLD); Haines, S. (Melbourne, VIC); Pradhan, A.
(Brisbane, QLD); Rendell, P.G. (Melbourne, VIC); Henry, J.D. (Brisbane, QLD)
Technological Section: Commentary
121 Social Isolation and Loneliness of Older Adults in Times of the COVID-19 Pandemic:
Can Use of Online Social Media Sites and Video Chats Assist in Mitigating Social
Isolation and Loneliness?
Hajek, A.; König, H.-H. (Hamburg)
© 2021 S. Karger AG, Basel
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