German Perspective on TB Prevention and Control in the SDG Era - Nita Perumal, RKI High-level event on the occasion of World Tuberculosis Day ...

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German Perspective on TB Prevention and Control in the SDG Era - Nita Perumal, RKI High-level event on the occasion of World Tuberculosis Day ...
German Perspective on TB
Prevention and Control in the
SDG Era
Nita Perumal, RKI

High-level event on the occasion of World
Tuberculosis Day, 20th March 2018
German Perspective on TB Prevention and Control in the SDG Era - Nita Perumal, RKI High-level event on the occasion of World Tuberculosis Day ...
Tuberculosis - one of the oldest diseases in the
   history of mankind

“Visiting the poor“
Source: Illustration von Karl Giradet aus “La Magasin Pittoresque“, Paris, 1844.

                                                                                   “Capital and Labour”
                                                                                   Source: Karikatur aus der englischen Zeitschrift “Punch”, 1843.

      20/03/2018                                                                                                                                     2
German Perspective on TB Prevention and Control in the SDG Era - Nita Perumal, RKI High-level event on the occasion of World Tuberculosis Day ...
Robert Koch discovered Mycobacterium
tuberculosis on March 24th, 1882

                                                                                                                                        Source: Wikimedia Commons. “Robert Koch in seinem
                                                                                                                                        Laboratorium“.

Source: Title page of Robert Koch's publication in the "Berliner Klinischen Wochenschrift" on April 10th, 1882, following his lecture
on March 24th, 1882, titled "The aetiology of tuberculosis".

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German Perspective on TB Prevention and Control in the SDG Era - Nita Perumal, RKI High-level event on the occasion of World Tuberculosis Day ...
DIAGNOSTIC Progress: TB is now
relatively easy to diagnose

                                                                                                        Source: Wikimedia Commons. GeneXpert™

                                                     Source: CDC/George P. Kubica (1979). CDC-PHIL ID
                                                     #5789. http://phil.cdc.gov/

   Source: Carl Mydans (1935). Library of Congress
   Prints and Photographs LC-DIG-fsa-8a00473

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German Perspective on TB Prevention and Control in the SDG Era - Nita Perumal, RKI High-level event on the occasion of World Tuberculosis Day ...
THERAPEUTIC Progress: TB can be
cured a large majority of the time
when the right combination of medications is made
available and the full course is taken by the patient

                                                                                                       Source: Pixabay

                                                       Source: Artificial pneuothorax at Stannington
                                                       Sanatorium. Wellcome Images.

    Source: Children in a TB sanatorium. The Finnish
    Museum of Photography. Wikimedia Commons.

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German Perspective on TB Prevention and Control in the SDG Era - Nita Perumal, RKI High-level event on the occasion of World Tuberculosis Day ...
Surveillance is key
                                                            TB mortality in Prussia, 1875 – 1910
                                                               Deaths per 10,000 population

      Dramatic fall in TB mortality, even
       during Robert Koch’s time

      Improved living conditions and
       nutrition through social and
       economic advancements

                                             Source: Robert Koch, Epidemiologie der Tuberkulose; Vortrag an der Akademie der Wissenschaften
                                             zu Berlin am 7. April 1910

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German Perspective on TB Prevention and Control in the SDG Era - Nita Perumal, RKI High-level event on the occasion of World Tuberculosis Day ...
TB Epidemiology in Germany, 2002-2017
                All Cases           Children only
                2017:       5,486   2017:           238
                2016:       5,949   2016:           228
                2015:       5,834   2015:           192

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German Perspective on TB Prevention and Control in the SDG Era - Nita Perumal, RKI High-level event on the occasion of World Tuberculosis Day ...
TB Treatment Outcomes in Germany, 2016

                                          90%
                                         WHO Goal

                                           81%
                                         Germany

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Reaching the End TB Strategy’s Pre-Elimination Goals

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What is Germany currently doing nationally?

          • Diagnosis,           • Contact tracing      • Electronic, case-
            treatment, and       • Targeted screening     based mandatory
            care in accordance                            reporting
            with TB standards
            of care

          Case                   Active case-
                                                        Surveillance
          Management             finding

          • Evidence-based,      • TB patients and      • National TB
            current guidelines     their families         meeting organized
          • Expert advice for    • General                every year for
            complicated cases      population             World TB Day

          Technical
                                 Information            Exchange
          Guidance

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What are Germany’s priorities?

                   Think TB!         Molecular Surveillance                                         United Effort

      Increasing awareness           Using the latest                                     Considerably greater
      and expertise among            technologies, establish                              and intensified collective
      medical professionals          nationwide integrated                                efforts to improve TB
      and other care givers to       molecular surveillance                               surveillance and control
      decrease diagnostic            to detect spread of TB                               and eventually reach the
      delay, secure adequate         early and conduct                                    goal of elimination.
      treatment, and prevent         systematic drug
      further disease.               resistance surveillance.
    Source: CDC. Think TB Poster.   Cole et al. Nature. 1998 Jun 11;393(6685):537-44.   Source: Pixabay

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Priorities for a global improvement in the
TB situation

      Development of new diagnostic methods and therapeutic agents, as well as a
       vaccine, necessary for worldwide TB control and elimination

      However, crucial to keep in mind the following :
         Barrier-free access to medical services that conform to international
          standards of care
         Optimal and best practice usage of recommended tools and measures
         Integrated and coordinated patient-centered approach

      Surveillance, including treatment outcome monitoring and resistance monitoring

    20/03/2018                                                                      12
Germany stands behind the goal of eliminating TB

      Germany recognizes and is cognizant of the global TB situation and the urgent
       need for action for its improvement. We have shown this through
         support and co-writing of the Berlin Declaration in 2007
         support for the inclusion of TB within the theme of antimicrobial resistance,
          which was one of the priorities during Germany’s G20 presidency in 2017
         participation in StopTB Partnership Board Meetings
         support for the Moscow Declaration following the Health Ministers’
          conference in 2017
         support and preparation for the UNGA high-level meetings, such as the
          upcoming meeting in New York in 2018, etc.

    It is urgent to use the current momentum to accelerate the TB elimination efforts!

    20/03/2018                                                                       13
Conclusion
             We do well, but could do even better.

                                But the strength of a small number of
                                medical men was inadequate to the
                                conflict with a disease so deeply
                                rooted in our habits and customs.
                                Such a conflict requires the co-
                                operation of many, if possible of all,
                                medical men, shoulder to shoulder
                                with the State and the whole
                                population.

                                - An address on the fight against tuberculosis in
                                the light of the experience that has been gained in
               © Foto RKI
                                the successful combat of other infectious
                                diseases. Robert Koch. London, 1901

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Thank you

                                                                       © Foto RKI

             TB-Team: Nita Perumal, Barbara Hauer, Bonita Brodhun, Stefan Kröger, Tanja Charles
             Unit Head: Walter Haas

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