Gall Bladder Mucocele in Dogs Diagnosis and Medical Management - JULIE STEGEMAN, DVM, DACVIM SOUTHERN CALIFORNIA VETERINARY SPECIALTY HOSPITAL
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Gall Bladder Mucocele in Dogs Diagnosis and Medical Management JULIE STEGEMAN, DVM, DACVIM SOUTHERN CALIFORNIA VETERINARY SPECIALTY HOSPITAL
Mucocele Definition Mucocele= distension of a cavity due to accumulation of mucus. Biliary mucocele= gall bladder full of thick green- black bile-laden semisolid to immobile mucoid mass AKA: Inspissated bile Mucinous hyperplasia Cystic mucinous hypertrophy Mucinous cholecystitis Cystic glandular cholecystitis
History 1965 first description as a finding in older dogs on necropsy 1984 Case report in JAVMA- ruptured mucocele 1989 described in Ettinger, 1993 Pathology Text 1995 Newell et al JAAHA reported on two non- ruptured mucoceles Mucocele was thought to develop from extrahepatic bilary obstruction Scintigraphy used to determine obstruction Icterus and vomiting recurred several months post- cholecystectomy in both dogs
History Gall bladder mucocele is now very commonly reported Increased use of ultrasound versus increased awareness??? Spike in literature reports since early 1990s Possible that necrotizing cholecystitis cases were mucoceles 50% of biliary rupture cases now seen are mucocele Crews et. al. JAVMA 2009
Etiology Ligation of CBD does NOT induce mucocele. Cystic hyperplasia of mucus-secreting cells lining the gall bladder to protect from bile salt damage Increased bile salt exposure with cholestasis Gall bladder hypomotility Increased water absorption from gall bladder lumen Sludge= cholesterol crystals + precipitated pigments + bile salts SEDIMENTS during the ultrasound exam May be a risk factor for some dogs
Etiology Accumulation of mucinous material in gall bladder with limited outflow induces pressure necrosis on biliary wall May be asymptomatic until time of rupture Important effects on the liver as well Biliary stasis and hyperplasia Suppurative cholangitis Periportal mixed cell hepatitis Periportal fibrosis
Risk Factors Breed association- Shelties, Cockers, Miniature Schnauzers, (Beagles, Miniature Poodle, Maltese,Bichon Frise) Hyperlipidemia, hypercholesterolemia High fat diets Hyperadrenocorticism Steroidogenic medications Hypothyroidism +/- NOT associated w/ diabetes
Steroids and Mucoceles 23% of Mucocele patients had Cushing’s Disease Pike et al JAVMA 2004 Dogs with hyperadrenocorticism have 29 times the risk of developing mucocele versus dogs without it Mosich et al JSAP 2009 Effect of steroids on gall bladder motility and/or bile salt composition? Effect of hyperlipidemia? ALL dogs with mucocele should be screened in some way for hyperadrenocorticism and hypothyroidism
Clinical Presentation Median age 9 years, either sex Any breed, but predispositions as listed previously May be completely asymptomatic, just elevated liver enzymes Symptoms Anorexia Abdominal pain Vomiting, possible diarrhea Possible fever Possibly polydipsic
Clinical Pathology Elevated ALKP (11-15X) Elevated GGT (2-8X) Elevated ALT (4-6X) Elevated Cholesterol (approx 75% of cases) Elevated T bili +/- (approx 50%) Leukocytosis +/- Hypoalbuminemia +/- Pancreatitis is not uncommon comorbid condition
Differential Diagnosis Pancreatitis with extrahepatic biliary obstruction Cholecystitis Acute hepatitis Leptospirosis Biliary mucocele
Sonographic diagnosis Classic “kiwi” appearance
Other ultrasound variations
Biliary Rupture Ultrasound is 86% sensitive to detect rupture Abdominal fluid bili > serum bili Cytology of Abdominal fluid- basophilic laminated, fibrillar strands of material JAVMA July 1,2011
Biliary rupture
Treatment Cholecystectomy is primary treatment Cholecystotomy and lavage NOT advised (recurs) +/- Prognosis worse if ruptured +/- Prognosis worse if infected CULTURE!! Enterobacter, E coli, Enterococcus, Staph Fluoroquinolone + Metronidazole vs Clavamox alone Older age and leukocytosis also may be negative prognostic factors
Postoperative care Antibiotics for several weeks afterward if culture + Ursodiol long term 10-15 mg/kg SID with food to ensure choleresis Low Fat diet CBD may remain dilated in about 30% Monitor liver enzymes- periportal hepatitis may continue and require therapy Postoperative or concurrent pancreatitis needs to be managed
5 months postop cholecystectomy 7 yr F/S Cocker Spaniel
Medical Therapy Only advisable if patient is asymptomatic and surgery is either high risk or declined by owner Ursodiol 20-25 mg/kg/day (high dose) Antibiotics +/- (Clavamox , or Fluoroquinolone + Metronidazole) S-adenosyl methionine 40 mg/kg/day (high dose) Low Fat Diet Identify and treat endocrinopathies! Walter et al JAVMA ‘08, 2 cases resolved with above. MUST FOLLOW CLOSELY!
Medical Therapy- an example “After” 2 months on “Before” medical Tx
Medical Therapy “Before” “After”- 5 months later 12 yr Miniature Schnauzer ( Walter et al JAVMA June 2008)
Mucocele and inflammatory hepatopathy I am seeing more cases of granulomatous hepatitis and other inflammatory hepatitis that resolve on immune suppressive medications, only to relapse with fever and icterus, and the gall bladder is the source. Some have early mucocele changes- from the steroids used to treat the disease? Should we take out gall bladders in our chronic hepatitis cases??? Which ones??
Mucocele –Hepatitis connection?
Early Detection/ Genetics Bile viscosity determined by concentration of mucin and phospholipids Phosphatidlycholine forms a micell with bile salts to solubilize and mobilize them. Low PC levels can lead to increased bile salt damage to biliary epithelium. ABCB4= translocates PC from hepatocyte to biliary canalicular lumen There is a mutation in ABCB4 in Shelties Dominant w/ incomplete penetrance.
Surgical Management Doctor Gassel………
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