Cognitive Focus New opportunities in functional beverage markets - Prinova
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Cognitive Focus New opportunities in functional beverage markets ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
01 of 14 COGNITIVE COGNITIVE FOCUS FOCUS. .NEW NEWOPPORTUNITIES OPPORTUNITIESININ FUNCTIONAL BEVERAGE MARKETS FUNCTIONAL BEVERAGE MARKETS Contents 02 Consumers increasingly have cognitive focus on the mind 02 Nootropic drinks ready to make a splash 03 Gaming set to power-up the market 04 New opportunities for nootropics across different formats 05 Natural nootropic ingredients on trend 06 Vital Vitamins and Minerals 07 Overcoming flavour challenges 08 Prinova: Branded ingredients with proven benefits 09 Prinova: Perfection in premixes 12 Prinova Europe: Your ideal partner for nootropics 13 References
02 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Consumers Nootropic drinks increasingly have ready to make a cognitive focus on splash the mind The percentage of global beverage launches featuring brain or nervous system claims has been steadily increasing over the last decade.3 More and more shoppers are seeking out ways to boost the brain. FMCG Gurus research carried With the market still very much in the early development out in 2021 shows that 66% of consumers phase, nootropic drinks are being tipped for substantial globally are now interested in cognitive health growth. Mintel describes beverages as “the obvious conduit” products, up from 53% three years earlier.1 for nootropics due to their ability to be digested more quickly than food, allowing them to boost the brain more rapidly.4 As a result, there is growing demand for nootropics among a wide range of demographic groups. Nootropics are Demand for nootropic beverages comes from a broad cognitive enhancers that can be incorporated into food, range of demographic groups, including busy professionals, drink and supplements to help improve functions such as students, athletes and gamers. Research also shows that focus and memory. They usually combine ingredients that many parents – and fathers in particular – are keen to work in synergy to enhance cognitive performance, reduce purchase energy drinks that can boost mood, concentration stress and fatigue, and deliver improvements in mood and and mental wellness.5 productivity. With Euromonitor’s 2020 Health and Nutrition Survey finding Demand for products with nootropic benefits has been rising that cognition and memory are widespread concerns for sharply: between 2015 and 2019, the number of nootropic consumers across all age groups6, it is clear that the nootropic product launches increased by an average of 70% per year beverage market has significant scope for expansion. globally.2 This white paper focuses on the huge potential for nootropic beverages as well as exploring the most effective ways to tap into the demand, looking at on-trend ingredients and exciting product concepts. ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
03 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Gaming set to power-up the market Gaming and eSports are shaping up to be a key The figures indicate that the nootropic beverage market has driver behind the nootropic beverage trend. the potential to reach the next level as gamers seek new Studies have found that nootropic products ways to feed brain function and health. can help gamers by increasing energy, reducing anger and decreasing errors while playing.7 % Who said these factors are important to them Many gamers are already purchasing drinks that can boost Easy to eat Easy58% to eat performance. For example, research carried out by the market Flavour 50% research firm Newzoo found that 15% of gamers in Western Europe regularly consume energy drinks while playing.8 Value for money 43% Easy to open 40% A survey conducted by Harris Interactive, meanwhile, shows that 35% of UK gamers buy food and drink specifically for Not messy 36% playing video games. Convenience is these gamers’ top Not sticky 29% priority, with 58% looking for easy-to-consume products. Gives me energy 25% A significant proportion are also seeking out the benefits Filling 25% provided by nootropic beverages: 25% said they look for Makes me alert food and drink that can give them energy and 18% search for 18% /helps me focus products that keep them alert and focused. Gives me energy 16% ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
04 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS New opportunities At present, most nootropics are sold as capsules, tablets and soft gels. As the trend gathers pace, for nootropics across though, there are growing opportunities to add brain- boosting benefits to functional drinks and tap into different formats the growing consumer demand for convenience.10 Energy Drinks Juices Between April 2019 and March 2020, 14% of all energy drink launches Juice drinks accounted for 14% of European beverage launches in Europe featured a functional claim around the brain and nervous featuring brain and nervous system claims between June 2019 and system. Caffeine is currently the most widely used nootropic June 2021. There may be opportunities for more nootropic launches across all beverages. Mintel suggests these drinks’ appeal could in this category, too, with 66% of European shoppers saying they are be increased by combining small doses of caffeine with additional interested in juice drinks that have been customized to meet their nootropic ingredients for a ‘360 degree’ brain boost. 12 individual nutrition needs.15 Gamer Drinks Gummies Gamer drinks form part of the wider gaming nutrition market, with Gummies represent a highly convenient format for supplements and an array of canned and powdered products available. Specifically are proving hugely popular among consumers. In fact, chewable developed for video game and eSports players, they are designed to vitamins are now the most common way for American adults aged 35 help maintain peak performance by boosting cognition and mental and younger to consume supplements.16 As such, they can provide a focus. A report on the gaming nutrition market published by the data good alternative to beverages within the nootropics market. insights company Nutrition Integrated found that there is scope for greater innovation in gamer drinks, going beyond caffeine to explore further cognitive benefits.13 Prinova offers a range of value- added capabilities, including: Full product development support for beverages, RTM powders, gummies, and capsules/tablets ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
05 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Natural nootropic Guarana (Paullinia Cupana) An Amazonian plant that contains the highest concentration ingredients on trend of caffeine of any wild plant.22 The active ingredient is extracted from the seeds and can help to enhance athletic performance, reduce mental and physical fatigue, and support cognitive performance including focus and mental alertness. Moreover, thanks to its tannin content, the Today’s consumers consider natural ingredients caffeine from guarana is released slowly and in a sustained increasingly appealing. For instance, nearly half manner, avoiding a spike and sudden crash. of all consumers worldwide now say natural Ginseng claims are important across carbonates, cordials, A root used for centuries in Chinese traditional medicine, chilled juices, and energy drinks.17 which has become one of the world’s most popular Here is a selection of some of the most popular natural medicinal herbs for its energy-boosting properties.23 Ginseng nootropic ingredients that offer scientifically backed brain may help stimulate physical and mental activity and reduce benefits. stress. Its ginsenoside content provides antioxidant and anti-inflammatory properties and could help improve brain functions. Yerba Mate Ashwagandha Sourced from the dried leaves and twigs of the Ilex The ashwagandha plant (Withania Somnifera) is a Paraguariensis plant and used to make a traditional South small shrub with yellow flowers and is one of the most American beverage that is said to have the strength of ancient herbs in Ayurvedic medicine. Its benefits include coffee, the health benefits of tea, and the joy of chocolate.18,19 improvements to memory and cognitive functions.24 Yerba mate is also widely used in supplements and, due to its caffeine content, it can help increase mental focus and Curcumin energy levels. In 2018, curcumin was officially established as a nootropic following the publication of a University of California (UCLA) Ginkgo Biloba study that showed significant improvements in memory An ancient Chinese tree that has long been cultivated for subjects who took supplements for 18 months.25 Brain for its health-promoting properties.20 Its main bioactive imaging in study participants revealed that curcumin had constituents are flavonoid glycosides and terpene lowered levels of amyloid and tau – the two proteins involved trilactones (ginkgolides and bilobalide). The presence of in Alzheimer’s disease. these active compounds increases the blood flow to various parts of the body, especially to the brain, supporting the Bacopa improvement of memory. A herb that is widely known for its natural memory enhancing effects. Used in Ayurvedic medicine, bacopa Rhodiola Rosea promotes nerve impulse transmission in the brain, facilitating A herb that grows in the cold regions of Europe and Asia. enhanced attention, memory and cognitive processing.26 Its main active compounds – rosavins and salidrosides – are found in its roots and are believed to provide anti- inflammatory and adaptogen benefits.21 As a result, the extract is commonly used to help the body adapt to stress Prinova can supply all these botanical and promote physical and mental performance. extracts and many more to boost energy, cognition and other functions ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
06 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Vital Vitamins & Minerals Nootropic drinks can benefit from a wide range of vitamins & minerals to boost the brain and more. Selenium Involved in various brain functions, including motor performance, coordination, memory and cognition. In neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and epilepsy, selenium metabolism seems to be altered – possibly due to pro-oxidative events accompanying these states. Zinc Deficiency is associated with neurological and psychological impairments.28 Calcium Regulates neurotransmission and controls nerve excitability.29 Magnesium A study found that administration of magnesium supplements to aged rats improved working and long- term memory.30 The magnesium in cell membranes is also important for the transmission of impulses. Furthermore, magnesium and calcium need to be present in ideal amounts in the body to prevent excitability of the nervous system. A deficiency of either one can lead to neurological problems. B Vitamins Considered particularly important for good brain health.31 Thiamin (B1) is one of the many B vitamins that is found abundantly in the brain and nerve tissue. It plays a role in the conduction of nerve impulses. Ascorbic Acid (Vitamin C) Important in the synthesis of the neurotransmitter dopamine as well as protecting the brain against oxidative stress.32 With the world’s largest inventory of food- grade single vitamins, Prinova can give you the ingredients you need, when you need them ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
07 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Overcoming flavour While sugar content is only the fourth priority, reductions can significantly add to products’ appeal. In Spain, for example, challenges nearly half (47%) of adults say they would drink, or drink more, energy drinks if they had less sugar. 34 Consumers’ desire to avoid both sugar and artificial ingredients can create challenges for manufacturers. As a When creating nootropic beverages, combining result, brands have been exploring new ways to mask bitter brain-boosting benefits with appealing flavours flavours or add sweetness. is crucial to product success. Most consumers For instance, flavours such as ginger and rhubarb can globally consider flavour to be their top priority offset the absence of sugar by shifting the focus away from when purchasing food and drink, followed by sweetness. Alternatively, botanicals including stevia and price, natural formulation, and no sugar. 33 vanilla extract can be used to make drinks naturally sweet. What do you prioritise when choosing which food and drink products to purchase? Prinova can provide formulation expertise with a wide selection of high Taste/flavour 16% and low-intensity sweeteners to create Price 14% the ideal taste profile Product is naturally formulated 11% Product is sugar-free 7% ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
08 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Prinova: Branded ingredients with proven benefits Prinova offers a wide range of branded ingredients as the result of exclusive partnerships and best-in-class scientific research. Here, we highlight Sabinsa’s wide range of premium botanical brain health ingredients, which are available in Europe through Prinova. Bacopin® is obtained from the leaves of the bacopa plant (Bacopa monnieri). The major constituents of bacopa are bacosides, which have been found to improve cognitive function. Bacopin® promotes nerve impulse transmission in the brain by helping to repair damaged neurons and inhibiting acetylcholinesterase (AChE). This facilitates enhanced attention, memory and cognitive processing, resulting in enhanced working memory. Containing a minimum of 40% elemental selenium, Selenium SeLECT® is a bioavailable and safe form of selenium for supplements.35 Selenium is an antioxidant trace mineral associated with reducing mental fatigue. Unlike other ® forms of the mineral, Selenium SeLECT® is a unique single chemical entity containing integrated selenium in place of sulphur in the amino acid methionine. It is directly incorporated into proteins in the body. Curcumin C3 Complex® is an extract derived from rhizomes (roots) of the turmeric plant (Curcuma longa).36 A study with Curcumin C3 Complex®, combined with a black pepper absorption booster BioPerine®, showed a reduction in an important inflammatory cytokine in traumatic brain injury patients. Shagandha™ is an ashwagandha root extract that meets the U.S. Pharmacopoeia-National Formulary (USP-NF) monograph and is verified by prominent botanical testing labs. It is ideal for nootropic products due to its ability to offer a wide range of cognitive health benefits.37, 38 For gamers and those who work with computers, eye health is an important concern. ZeaLutein® is a natural phytocomplex of 1% zeaxanthin, 5% lutein, and 2% piperine, blended in a ratio optimized to provide maximum benefits for eye health. Lutein and zeaxanthin can filter harmful high-energy blue wavelengths of light and help protect and maintain healthy cells in the eyes. Several studies have suggested that dietary supplementation with lutein and zeaxanthin could protect the retina and delay the progression of age-related macular degeneration. 39 Prinova’s vast range of innovative branded ingredients can help you stay ahead of consumer trends and create products that stand out ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
09 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Prinova: Perfection in premixes Prinova can deliver bespoke premixes that make it easy to create winning nootropic supplements for gamers and other key target groups. Here, we showcase a selection of concepts with a variety of cognitive benefits and exciting flavours. Herbal Energy Drink Revitalize Energy Strawberry and yuzu-flavoured energy drink containing all- Peach tea-flavoured energy drink with vitamins. natural ingredients including yerba mate. • 100mg of natural caffeine per can • Vitamin B1, B2, B6 and B12 contribute to normal energy yielding • Mixture of extracts including metabolism trending yerba mate • Vitamin C, B2, B3, B6 and B12 • Primary natural caffeine coming contribute to the reduction of from green coffee extract tiredness and fatigue Nutritional info per 330ml can Nutritional info per 330ml can Energy KJ / Kcal 200kJ / 48Kcal Energy KJ / Kcal 126kJ / 30Kcal Protein (g) 0 Protein (g) 0 Carbohydrates (g) 10 Carbohydrates (g) 7 Of which sugars (g) 9 Of which sugars (g) 6 Fats (g) 0 Fats (g) 0 Of which saturates (g) 0 Of which saturates (g) 0 Salt (g) 0 Salt (g) 0 Natural Caffeine 100mg Vitamin C 8mg (10% NRV) Vitamin B1 0.11mg (10% NRV) Ingredients: Purified Sparkling Water, Beet Sugar, Lemon Juice form Riboflavin B2 0.14mg (10% NRV) concentrate (4%), Herbal Extracts (Green Tea, Guarana, Green Coffee, Yerba Mate), Natural Flavourings. Niacin B3 1.6mg (10% NRV) Vitamin B6 0.14mg (10% NRV) Vitamin B12 0.25mg (10% NRV) Ingredients: Fruit Juice from Concentrate (Peach 38%, Apple 15%), Carbonated Water, Natural Flavourings, Acid (Citric Acid), Vitamins (C, Niacin, Thiamin, B6, Riboflavin, B12), Preservative (Potassium Sorbate). ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
10 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Gamer Energy Drink Gamer Cognition Powder Rainbow sherbet-flavoured nootropic energy drink Strawberry kiwi-flavoured nootropic energy powder containing caffeine, amino acids and Bacopin™ for eSports containing caffeine, amino acids, Bacopin™ and ZeaLutein™ enthusiasts • Includes an electrolyte blend to aid hydration and help gamers maintain peak performance • Includes amino acids Tyrosine, • Incorporates an eye support blend, Theanine and Taurine, which have ZeaLutein™, which helps protect the been shown to help concentration eyes from harmful blue light • Bacopin™ improves memory and • Added Bacopin™ shown to improve cognition memory and cognition • Panax ginseng and natural caffeine provide increased stamina Nutritional info per 330ml can NRV Cognition & Focus Blend N-Acetly L-Tyrosine 1000 mg Nutritional info per 550ml can Taurine 1000 mg - Acetyl L-Carnitine 500 mg - Energy KJ / Kcal 25kJ / 5Kcal Alpha GPC 300 mg - Protein (g) 0 Bacopin® (20% Bacosides) 250 mg - Carbohydrates (g) 0 Green Tea Extract 98% L-Theanine 200 mg - Of which sugars (g) 0 Natural Caffeine Anhydrous 100 mg - Fats (g) 0 Ginseng Extract (20% Ginsenosides) 100 mg - Of which saturates (g) 0 Eye Health Complex Salt (g) 0.15 ZeaLutein™ (1% Zeaxanthin, 5% Lutein, 2% Piperine) 100 mg - N-Acetly L-Tyrosine 1000mg Taurine 1000mg Vitamin E (as dl-a-Tocopheryl Acetate) 12 mg TE 100% Bacopin™ (20% Bacosides) 250mg Zinc (as Zinc Citrate) 10 mg 100% Green Tea Extract 98% L-Theanine 200mg Hydration Blend Panax Ginseng Extract 100mg Coconut Water Powder 250 mg - Natural Caffeine Anhydrous 100mg Sodium (as Sodium Chloride) 150 mg - Ingredients: Purified Sparkling Water, N-Acetyl L-Tyrosine, Taurine, Bacopin™ Potassium (as Potassium Chloride) 100 mg 5% (Bacopa Monnieri Extract), Green Tea Extract 98% L-Theanine, Ginseng Magnesium (as Tri-Magnesium Citrate) 56.25 mg 15% Extract, Natural Caffeine Anhydrous, Vitamin C (as Ascorbic Acid), Vitamin B3 (as Niacinamide), Vitamin B5 (as Calcium D-Pantothenate), Vitamin D3 (as Calcium (as Calcium Carbonate) 50 mg 6% Cholecalciferol), Vitamin B12 (as Cyanocobalamin), Vitamin B6 (as Pyridoxine Energy Support Blend Hydrochloride). Flavourings. Vitamin C (as Ascorbic Acid) 100 mg 125% Vitamin B3 (as Niacinamide) 16 mg 100% Vitamin B5 (as Calcium D-Pantothenate 6 mg 100% Vitamin B6 (as Pyridoxine Hydrochloride) 1.4 mg 100% Vitamin D3 (as Cholecalciferol) 10 mcg 200% Vitamin B12 (as Cyanocobalamin) 2.5 mcg 100% Ingredients: N-Acetyl L-Tyrosine, Taurine, Acetyl L-Carnitine, Sodium Chloride, Tri-Magnesium Citrate, L-Alphaglycerylphosphorylcholine, Bacopin® (Bacopa Monnieri Extract), Coconut Water Powder, Green Tea Extract 98% L-Theanine, Ginseng Extract, Potassium Chloride, Calcium Carbonate, Natural Caffeine Anhydrous, ZeaLutein™, Vitamin C (as Ascorbic Acid), Zinc (as Zinc Oxide), Vitamin E (as dl-a-Tocopheryl Acetate), Vitamin B3 (as Niacinamide), Vitamin B5 (as Calcium D-Pantothenate), Vitamin D3 (as Cholecalciferol), Vitamin B12 (as Cyanocobalamin), Vitamin B6 (as Pyridoxine Hydrochloride) ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
11 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Energize Juice Focus Gummies A blend of five fruit juices, purees and extracts with added Tropical fruit-flavoured gummies with vitamins, minerals and magnesium and vitamins. extracts to improve mental focus without added stimulants. • Includes an electrolyte blend to aid • Aquamin™ Magnesium from pure Irish hydration and help gamers maintain sea water peak performance • B vitamins and magnesium contribute • Incorporates Aquamin™ magnesium to a reduction in tiredness to support the reduction of tiredness and fatigue • Added ginseng and ginger for energy and stamina • Added Bacopin™ shown to improve memory and cognition Nutrient (Ingredient Requested Nutrient %DV/ Nutritional info per 150ml serving Form Used) Level (300mg) %RDI Energy KJ / Kcal 281kJ / 66kcal Iodine (as Potassium Iodide) 22.5 mcg 15% Protein (g) 0.2 Niacin (as Niacinamide) 2.4 mg 15% Carbohydrates (g) 16 Pantothenic Acid (as D-Calcium Pantothenate) 0.9 mg 15% Of which sugars (g) 13 Vitamin B12 (as Cyanocobalamin) 0.375 mcg 15% Fats (g) 0 Of which saturates (g) 0 Vitamin C (as Ascorbic Acid) 12 mg 15% Salt (g) 0 Zinc (as Zinc Sulfate 1H2O) 1.5 mg 15% Magnesium 56mg (15% NRV) Magnesium (as AQUAMIN™ 56.25 mg 15% MG SOLUBLE) Thiamin B1 (Thiamin) 0.42 mg (38% NRV) Riboflavin B2 (Riboflavin) 0.48 mg (34% NRV) Bacopin® 50 mg - Vitamin B6 0.6 mg (43% NRV) Maltodextrin, Non-GMO Q.S. - Ingredients: Fruit Juices and Purees (94%) [Apple Juice (62%), Orange Juice (15%), Carrot (5%), Banana Puree (12%)], Lemon Juice, Aquamin™ (a Natural Magnesium Source [Magnesium Citrate]), Ginseng Root Extract, Ginger Root Extract, Vitamins (B1, B2, B6) ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
12 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS Prinova Europe: Your ideal partner for nootropics Prinova’s branded ingredients and on-trend formulations can set your products apart. We will work with you from start to finish to bring your ideas to life with our full range of product development services. From initial concept to final delivery, you have complete control — giving you the power get to market quickly. Prinova’s expansive product and service offering is underpinned by the highest quality standards, while we can also help you through regulatory challenges. * Please note that nutrition and health claims are regulated in many markets so the specific wording used needs to be reviewed on an individual product basis’ Contact us now and we can help you to create the innovative nootropics products that today’s consumers want to see: info@prinovaglobal.com ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
13 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS References 1 FMCG Gurus 'The Growing Importance of Cognitive Health' 19 Heck, C.I. & de Mejia, E.G. 'Yerba Mate Tea (Ilex (2021) paraguariensis): a comprehensive review on chemistry, health implications, and technological considerations' 2 Nutrition Insight 'Brain Boosters: The Rise of Natural Journal of Food Science (2007) Nootropics in the Emerging E-gamers Segment' (2020) 20 Silberstein, R.B. et al. 'Examining brain-cognition effects of 3 Mintel GNPD (2021) ginkgo biloba extract: brain activation in the left temporal 4 Mintel 'Nootropics are the future of functional drinks' and left prefrontal cortex in an object working memory (2020) task' Evidence-Based Complementary and Alternative Medicine (2011) 5 Mintel 'Dads are a vital audience for sports and energy drinks' (2021) 21 Pu, W.L. et al. 'Anti-inflammatory effects of Rhodiola rosea L.: A review' Biomedicine & Pharmacotherapy (2020) 6 Euromonitor 'Cognitive Performance Remains Top Of Mind For Consumers' (2020) 22 del Giglio, A. & del Giglio, A. 'Using Paullinia cupana (Guarana) to Treat Fatigue and Other Symptoms of Cancer 7 Tartar, J.L., Kalman, D. & Hewlings, S. 'A Prospective and Cancer Treatment' Bioactive Nutraceuticals and Study Evaluating the Effects of a Nutritional Supplement Dietary Supplements in Neurological and Brain Disease Intervention on Cognition, Mood States, and Mental (2015) Performance in Video Gamers' Nutrients (2019) 23 Im, D.S. & Nah, S.Y. 'Yin and Yang of ginseng pharmacology: 8 Newzoo '80% of Gamers Regularly Eat or Drink While ginsenosides vs gintonin' Acta Pharmaceutica Sinica B Playing: Gamer Consumption Habits in North America, (2013) Western Europe & APAC' (2020) 24 Choudhary, D., Bhattacharyya, S. & Bose, S. 'Efficacy 9 The Grocer 'Game on: Why FMCG is making a serious play and Safety of Ashwagandha (Withania somnifera (L.) for gaming and eSports' (2019) Dunal) Root Extract in Improving Memory and Cognitive 10 FMCG Gurus 'Convenience & Simplicity – Global' (2020) Functions' Journal of Dietary Supplements (2017) 11 Mintel GNPD (2021) 25 Small, G.W. et al. 'Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non- 12 Mintel 'Nootropics are the future of functional drinks' Demented Adults: A Double-Blind, Placebo-Controlled (2020) 18-Month Trial' The American Journal of Geriatric Psychiatry (2018) 13 Nutrition Integrated 'Gaming Nutrition – A Leap Into The Virtual World' (2021) 26 Aguiar, S. & Borowski, T. 'Neuropharmacological review of the nootropic herb Bacopa monnieri' Rejuvenation 14 Mintel GNPD (2021) Research (2013) 15 FMCG Gurus 'Beverage Trends in 2021' (2021) 27 Solovyev, N.D. 'Importance of selenium and selenoprotein 16 Business Insider 'The weird science behind stuffing a for brain function: From antioxidant protection to neuronal sugary gummy treat full of vitamins' (2020) signalling' Journal of Inorganic Biochemistry (2015) 17 FMCG Gurus 'Three Key Beverage Trends in 2021' (2021) 28 Szewczyk, B. 'Zinc homeostasis and neurodegenerative disorders' Frontiers in Aging Neuroscience (2013) 18 Healthline.com '8 Health Benefits of Yerba Mate (Backed by Science)' (2018) 29 Lu, B. et al. 'Extracellular calcium controls background ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
14 of 14 COGNITIVE FOCUS . NEW OPPORTUNITIES IN FUNCTIONAL BEVERAGE MARKETS current and neuronal excitability via an UNC79-UNC80- NALCN cation channel complex' Neuron (2010) 30 Slutsky, I. et al. 'Enhancement of learning and memory by elevating brain magnesium' Neuron (2010) 31 Kennedy, D.O. 'B Vitamins and the Brain: Mechanisms, Dose and Efficacy – A Review' Nutrients (2016) 32 Harrison, F.E. & May, J.M. 'Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2.” Free Radical Biology & Medicine (2009) 33 FMCG Gurus 'The Future of Naturalness 2020' (2020) 34 Mintel 'A year of innovation in sports and energy drinks' (2020) 35 Sabinsa: https://seleniumselect.com/ 36 Sabinsa: https://sabinsa.com/newsroom/sabinsa- productsfaq/curcumin-c3-complex-faq 37 Chandrasekhar, K., Kapoor, J. & Anishetty S. 'A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults' Indian Journal of Psychological Medicine (2012) 38 Choudhary, D. et al. 'Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions' Journal of Dietary Supplements (2017) 39 Sabinsa: https://zealutein.com/research.html ©2021 Prinova Europe Ltd. All rights reserved. prinovaglobal.com/eu
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