BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION

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BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
BOSTON | FEBRUARY 2020

        BUILDING
        BLOCKS
                         THE DNA OF LAB
                         CONSTRUCTION
BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
TABLE OF
CONTENTS
THE DNA OF BOSTON’S LAB CONSTRUCTION  .  .  .  .  .  .  . 1-2

LIFE SCIENCE DEVELOPMENT LANDSCAPE .  .  .  .  .  .  .  . 3-4

2020 – 2021 DEVELOPMENTS  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  . 5-9

2022 - 2023 DEVELOPMENTS  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  . 10-14

2024 - BEYOND DEVELOPMENTS  .  .  .  .  .  .  .  .  .  .  .  .  .  .  .  . 15-18

5 FACTS OF LIFE SCIENCE DEVELOPMENT  .  .  .  .  .  . 19-20
BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
THE DNA OF BOSTON’S                                                                                                                                  NEW LABORATORY DELIVERIES IN GREATER BOSTON

          LAB CONSTRUCTION
                                                                                                                                                                            6.0

                                                                                                                                                                            5.0

                                                                                                                                                                            4.0

                                                                                                                                                              SF MILLIONS
                                                                                                                                                                            3.0

          The narrative surrounding Boston’s lab market has been characterized with outsized demand, limited supply and swelling                                            2.0
          rental rates. Conditions have been ripe for construction activity and developers are responding with new projects to take                                         1.0
          advantage of such tight market fundamentals. With an ever-expanding planning pipeline, this market could see several                                              0.0
          million square feet of lab space come on line over the next 5+ years. While Cambridge remains the epicenter of life science
                                                                                                                                                                                  2010    2011     2012    2013   2014   2015      2016   2017    2018    2019      2020    2021     2022     2023     2024+
          activity, dwindling developable sites and non-existent vacancies have tenants, landlords and everyone in-between gravitating
          toward alternative markets to meet their needs. As a result, new and emerging life science clusters are sprouting up in areas                                                                              CAMBRIDGE                   BOSTON & SUBURBS
          like the Seaport District, Fenway, Allston-Brighton, Somerville, South Boston, and Watertown.
                                                                                                                                                                             NOTE: FUTURE SUPPLY INCLUDES ALL RENTABLE BUILDING AREA WITHIN MIXED-USE PROJECTS WHERE LABORATORY SPACE CAN BE DELIVERED
                                                                                                                                                                                                                                                                                            Source: NKF Research

          NEW DEVELOPMENTS                                                                       15.8 million square feet — representing 74% of current        Avenue in Mid Cambridge totaling 542,000 square feet,                       The overall cost to build in this market, particularly in
                                                                                                 rentable building area. It is unlikely all of the proposed    Vertex’s one million-square-foot build-to-suit in the Seaport               urban areas like Boston and Cambridge, is especially high.
          RESPOND TO DEMAND                                                                      projects will move forward or include only life science       and Alexandria Real Estate’s 521,489-square-foot 50-60                      Moreover, construction costs on lab product tend to
          The depth of future lab demand remains uncertain as                                    uses, but the pipeline should be monitored closely.           Binney Street in Kendall Square. Several major projects are                 outstrip traditional office space due to necessary base
          a wave of new supply looms. As we continue to move                                                                                                   also actively under construction. Related Beal has moved                    building infrastructure and specialty installations. Looking
          through the late-stage growth phase of this current                                    Developers were rather active this past cycle, with nearly    forward on the 250,000-square-foot second phase of iSQ                      at average tenant improvement allowances (TI) over the
          expansion cycle, tenants may take a “wait-and-see”                                     6.2 million square feet of new lab supply delivering from     on Northern Avenue in the Seaport, while MIT, Bulfinch and                  last ten years, it’s clear that fit outs for life science users
          approach when considering their real estate needs and                                  2010-2019 throughout the Boston metro area. The               DivcoWest are adding nearly two million square feet in East                 have become especially costly. As of 2019, average TIs
          weigh on the market’s recent rapid growth patterns. If                                 Cambridge markets accounted for more than 60% of this         and West Cambridge. Looking ahead, developers appear                        reached a peak of more than $139/SF on lab deals across
          every project with the potential for lab space were to                                 new space. Some of the largest developments to date           to have set their sights on Boston and the Suburbs, which                   the metro area with select transactions in Cambridge
          deliver, Greater Boston’s inventory would increase by another                          include a build-to-suit by Novartis at 181 Massachusetts      account for 60% of forecasted lab deliveries.                               reaching $275/SF.

    LEXINGTON                                                                                                                      LIFE SCIENCE                             AVERAGE TENANT
                                                                                                                                   CLUSTERS                                 IMPROVEMENT
                                                                                                                                                                            ALLOWANCES
                                                                                                                                        EMERGING
                                                                                                                                        BURGEONING                                                                                                                                               2019
                                                                  SOMERVILLE
                                                                                                                                        ESTABLISHED
WALTHAM
                                                 WEST
                                               CAMBRIDGE
                                                                                                                                                                                                                                2014                                               2018
                                                                                                                                                                                                    2012
                        WATERTOWN                              MID      EAST
                                                                                                                                                                                                                  2013                    2015                      2017
                                                            CAMBRIDGE CAMBRIDGE
                                                                                                                                                                                   2010
                                                  ALLSTON                                                                                                                                   2011                                                      2016
          2020 – 2021                                                                                                                                                                                                                                                                       Source: NKF Research
                                    BRIGHTON                                           SEAPORT
                                                                  FENWAY
                                                                               SOUTH
                                                                                END

                                                            LMA

                                                                                                                                                                                                                                                                 © NEWMARK KNIGHT FRANK | RESEARCH | 2020          2
BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
LEXINGTON

                                                                                                        MALDEN

                   V
                   U 2                          ARLINGTON
                                                                                  MEDFORD

                                                                            ¨                                    ¤
                                                                                                                 £                         ¨
     WALTHAM
                                     BELMONT
                                                                            ¦
                                                                            §93
                                                                                                                  1

                                                                                                                                           ¦
                                                                                                                                           § 90

               LIFE SCIENCE                                                   SOMERVILLE

               DEVELOPMENT
               LANDSCAPE                                             CAMBRIDGE
                                          WATERTOWN
                                                                                                                               LOGAN
                                                                                                      BOSTON
¨
¦
§
95
                                               ¨
                                               ¦
                                               §90
                                                                                                                               INTERNATIONAL
                                                                                                                               AIRPORT

                                                      ALLSTON
                YEAR OF DELIVERY

                     2020 — 2021
                                                                                                                                                     Boston Harbor
                     2022 — 2023
                                                                BROOKLINE                              SOUTH BOSTON
                     2024 — Beyond

                                               V
                                               U 9
                                                                      JAMAICA PLAIN
                                                                                       ROXBURY

                                                                                                 ¨
                                                                                                 ¦
                                                                                                 §
                                                                                                 93

                                                                                                                      Dorchester Bay

                                                                                                                       © NEWMARK KNIGHT FRANK | RESEARCH | 2020      4
BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
4

                 2                                                                                               Cambridge Discovery Park Bldg 400/500, West Cambridge
8                                                                                                            2   DEVELOPER: The Bulfinch Companies
                                                                                                                 RENTABLE BUILDING AREA: 270,000 SF
                     11
                           19 10
                                                                                                                 ESTIMATED DELIVERY: 1Q 2020
                                                                                                                 PRE-LEASED: 88%
            12                                                                                                   TENANTS: Fog Pharmaceuticals, Kintai Therapeutics, Simcere Innovation and Arbor
                                                                                                                 Biotechnologies
                                                                                                                 DETAILS: Speculative building within Bulfinch’s three-building laboratory and office
                           6             7         5                                                             development at Cambridge Discovery Park in Alewife.

                                                 13
                                             3                                                                   The BEAT, Boston - Dorchester
                                                                                                             3   DEVELOPER: Nordblom Company and Alcion Ventures
                                                                                                                 RENTABLE BUILDING AREA: 693,900 SF (lab & office)
                                                                                                                 ESTIMATED DELIVERY: 2Q 2020
                                                                                                                 PRE-LEASED: 0%
                                                                                                                 TENANTS: N/A
                                                                                                                 DETAILS: Fully renovated former headquarters of The Boston Globe. Fully-amenitized,
                                                                                                                 three-story building for creative laboratory and office use located minutes from the
                                                                                                                 MBTA Red Line.

                                                                                                                 75 Hayden Ave, Lexington
            2020 - 2021                                                                                      4   DEVELOPER: King Street Properties
                                                                                                                 RENTABLE BUILDING AREA: 213,900 SF

            DEVELOPMENTS
                                                                                                                 ESTIMATED DELIVERY: 3Q 2020
                                                                                                                 PRE-LEASED: 57%
                                                                                                                 TENANTS: Dicerna Pharmaceuticals and Frequency Therapeutics
                                                                                                                 DETAILS: Fourth building within the Hayden Research Campus that will total more
                                                                                                                 than 600,000 SF upon the building’s completion. Neighboring tenants include Takeda
                                                                                                                 Pharmaceuticals, Concert Pharmaceuticals, and Kaleido Biosciences. Premier
                                                                                                                 suburban location with convenient access to Route 2 and I-95.

                      222 Jacobs St - Cambridge Crossing, East Cambridge
        1             DEVELOPER: DivcoWest
                      RENTABLE BUILDING AREA: 430,000 SF (lab & office)
                      ESTIMATED DELIVERY: 1Q 2020
                      PRE-LEASED: 100%
                      TENANTS: Philips and Cerevel Therapeutics
                      DETAILS: First building to deliver within the +2.2 MSF laboratory and office
                      development. Philips has leased 80% of the building and will relocate its operations
                      from Andover in early 2020.

                                                                                                                                                       © NEWMARK KNIGHT FRANK | RESEARCH | 2020         6
BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
iSQ Phase II, Boston - Seaport District                                                    250 Water St - Cambridge Crossing, East Cambridge
5   DEVELOPER: Related Beal and Kavanagh Advisory Group
                                                                                          9    DEVELOPER: DivcoWest
    RENTABLE BUILDING AREA: 250,000 SF                                                         RENTABLE BUILDING AREA: 504,000 SF (lab & office)
    ESTIMATED DELIVERY: 2Q 2021                                                                ESTIMATED DELIVERY: 4Q 2021
    PRE-LEASED: 100%                                                                           PRE-LEASED: 0%
    TENANTS: Vertex Pharmaceuticals
                                                                                               TENANTS: N/A
    DETAILS: Second phase of a 375,000 SF laboratory development located in the
    Raymond L. Flynn Marine Park and recently leased to Vertex, which occupies                 DETAILS: Construction of a nine-story building on Parcel EF at Cambridge Crossing.
    an additional 1.1 MSF in the Seaport. Phase I tenants include SmartLabs and                The building will feature 56,000 SF floor plates and include approximately 2,600 SF
    PureTech Health.                                                                           of retail space, 379 underground parking spaces, and 100 bicycle storage spaces.

    238 Main St, East Cambridge                                                                350 & 450 Water St - Cambridge Crossing, East Cambridge
6   DEVELOPER: MIT Investment Management Co.                                              10   DEVELOPER: DivcoWest
    RENTABLE BUILDING AREA: 308,800 SF                                                         RENTABLE BUILDING AREA: 915,000 SF
    ESTIMATED DELIVERY: 3Q 2021                                                                ESTIMATED DELIVERY: 4Q 2021
    PRE-LEASED: 100%                                                                           PRE-LEASED: 100%
    TENANTS: Beam Therapeutics, LabCentral and Bayer                                           TENANTS: Sanofi
    DETAILS: Part of the MIT Kendall Square Initiative. New construction of a 12-story         DETAILS: Build-to-suit for Sanofi. 350 Water Street (Parcel G) is a 12-story building
    tower that will connect to an existing, renovated building on the first six floors.        comprised of 500,000 SF of laboratory space, while 450 Water Street (Parcel H) is a
    Adjacent to 314 Main Street, a 355,000 SF office building also underway.                   nine-story building comprised of 415,000 SF of office space. Both buildings will have
                                                                                               ground floor retail and a total of 850 parking spaces.

    The 105 by Breakthrough, Boston - Seaport District                                         101 South St - Boynton Yards Phase I, Somerville
7   DEVELOPER: Breakthrough Properties (Bellco Capital and Tishman Speyer JV)
                                                                                          11   DEVELOPER: DLJ Real Estate Capital Partners and Leggat McCall Properties
    RENTABLE BUILDING AREA: 248,000 SF                                                         RENTABLE BUILDING AREA: 275,100 SF (lab & office)
    ESTIMATED DELIVERY: 4Q 2021                                                                ESTIMATED DELIVERY: 4Q 2021
    PRE-LEASED: 0%                                                                             PRE-LEASED: 0%
    TENANTS: N/A                                                                               TENANTS: N/A
    DETAILS: Speculative redevelopment of the former RCN building where South
                                                                                               DETAILS: Part of a two-phase mixed-use development that will span more than
    Boston meets the Seaport District. First life science development for Breakthrough
                                                                                               1.0 MSF. A nine-story speculative laboratory and office building is currently
    Properties in Boston.
                                                                                               underway, with delivery coinciding with the planned completion of the MBTA Green
                                                                                               Line extension to Union Square.

    300 Third Ave, Waltham
8   DEVELOPER: Lincoln Property Company
    RENTABLE BUILDING AREA: 139,600 SF
    ESTIMATED DELIVERY: 4Q 2021
    PRE-LEASED: 0%
    TENANTS: N/A
    DETAILS: The redevelopment of a two-story office building into a new four-story
    laboratory and office building overlooking Route 128 in Waltham. The project will
    feature 35,000 SF floor plates and 443 parking spaces.

                                                                                                                                     © NEWMARK KNIGHT FRANK | RESEARCH | 2020          8
BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
481 Arsenal St, Watertown
                                                                                                 9
12   DEVELOPER: Boylston Properties                                                                       15 10                    12
     RENTABLE BUILDING AREA: 155,000 SF
                                                                                                                           7            6
     ESTIMATED DELIVERY: 4Q 2021
     PRE-LEASED: 0%                                                                                                                14
     TENANTS: N/A                                                                                                 11           8
     DETAILS: Building G within the redevelopment and expansion of Arsenal Yards. Initially
     slated for residential use, the developer is now targeting life science tenants after not                                                  34
     receiving desired height approvals and the successful lease up of 480 Arsenal Street.                             1                    2        13
                                                                                                                                        5

     1 Harbor St, Boston – Seaport District
13   DEVELOPER: Millennium Partners and Cargo Ventures
     RENTABLE BUILDING AREA: 130,000 SF
     ESTIMATED DELIVERY: 4Q 2021
     PRE-LEASED: 0%
     TENANTS: N/A
     DETAILS: Former warehouse that will be redeveloped into a two-story laboratory and
     R&D building. Situated at the intersection of Harbor Street and Northern Avenue, the
     project is adjacent to the joint developers’ scaled back innovation campus at 329
     Northern Avenue, which is still slated to include 381,000 SF.

                                                                                                         2022 - 2023
                                                                                                         DEVELOPMENTS

                                                                                                                       201 Brookline Ave, Boston - Fenway
                                                                                                     1                 DEVELOPER: Samuels & Associates
                                                                                                                       RENTABLE BUILDING AREA: 500,000 SF
                                                                                                                       ESTIMATED DELIVERY: 2022
                                                                                                                       PRE-LEASED: 18%
                                                                                                                       TENANTS: Tango Therapeutics and Third Rock Ventures
                                                                                                                       DETAILS: Construction of a 14-story laboratory and office building located at the
                                                                                                                       southwest corner of Brookline Avenue and Fullerton Street. Part of the approved
                                                                                                                       expansion of the existing 401 Park Dr in the Fenway neighborhood.

                                                                                                                                                             © NEWMARK KNIGHT FRANK | RESEARCH | 2020      10
BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
10 Stack St - Hood Park, Charlestown
                                                                                                        6   DEVELOPER: Catamount Management
                                                                                                            RENTABLE BUILDING AREA: 350,000 SF
    99 A St, Boston - Seaport District
2   DEVELOPER: Alexandria Real Estate Equities and Anchor Line Partners
                                                                                                            ESTIMATED DELIVERY: 2022
                                                                                                            PRE-LEASED: 0%
    RENTABLE BUILDING AREA: 210,000 SF
                                                                                                            TENANTS: N/A
    ESTIMATED DELIVERY: 2022
                                                                                                            DETAILS: First planned building within the approved redevelopment at Hood Park
    PRE-LEASED: 0%                                                                                          which encompasses 20 acres and 1.8 MSF of mixed-use space. 10 Stack Street will
    TENANTS: N/A                                                                                            include 149 below-ground parking spaces and outdoor terraces at the second and
    DETAILS: Located across the street from Breakthrough Properties’ laboratory building                    top floors.
    at 105 W First Street, this six-story building is in the final permitting stage with
    construction set to begin in early 2021. The property is roughly a five-minute walk
    from the MBTA Red Line Broadway Station in South Boston.

                                                                                                            30 Prospect St - USQ Phase I, Somerville
                                                                                                        7   DEVELOPER: US2
    15 Necco St (GE site) & 10 Necco St (Garage), Boston - Seaport District
3   DEVELOPER: Alexandria Real Estate Equities and National Development
                                                                                                            RENTABLE BUILDING AREA: 178,000 SF
                                                                                                            ESTIMATED DELIVERY: 2022
    RENTABLE BUILDING AREA: 316,000 SF & 160,000 SF
                                                                                                            PRE-LEASED: 0%
    ESTIMATED DELIVERY: 2022
                                                                                                            TENANTS: N/A
    PRE-LEASED: 0%
                                                                                                            DETAILS: Part of the first phase of the planned 2.4 MSF mixed-use development in
    TENANTS: N/A
                                                                                                            Somerville that will span 15.7 acres and feature lab, office, residential, and retail
    DETAILS: After abandoning plans to develop a new headquarters building at 15 Necco                      space. Approximately 60% of the development will be commercial use, with 40% for
    Street, General Electric sold the site to Alexandria and National Development in                        residential use and 3.5 acres of open space.
    mid-2019. Plans for a 316,000 SF building are currently under review. 10 Necco Street
    is a six-story parking structure that was acquired by the same group last year and is
    expected to undergo renovation that will include four additional floors of lab-ready use.

                                                                                                            325 Binney St, East Cambridge
    350 Summer St, Boston - Seaport District                                                            8
4   DEVELOPER: WS Development
                                                                                                            DEVELOPER: Alexandria Real Estate Equities
                                                                                                            RENTABLE BUILDING AREA: 228,000 SF
    RENTABLE BUILDING AREA: 384,000 SF
                                                                                                            ESTIMATED DELIVERY: 2022
    ESTIMATED DELIVERY: 2022
                                                                                                            PRE-LEASED: 0%
    PRE-LEASED: 0%
                                                                                                            TENANTS: N/A
    TENANTS: N/A
                                                                                                            DETAILS: A 3.6-acre site located adjacent to Alexandria’s One Kendall Square
    DETAILS: Also known as Seaport Square Block N, this parcel recently underwent a                         complex. The building may be expandable in the future.
    notice of project change from residential to laboratory and office use. Located next
    to the future home of Foundation Medicine, which commissioned a 581,000 SF
    build-to-suit office building on Block P in mid-2019.

    Exchange South End Phase I, Boston - South End                                                          225 Wyman St, Waltham
5   DEVELOPER: The Abbey Group
                                                                                                        9   DEVELOPER: Hobbs Brook Management
    RENTABLE BUILDING AREA: 690,000 SF (lab & office)                                                       RENTABLE BUILDING AREA: 507,600 SF
    ESTIMATED DELIVERY: 2022                                                                                ESTIMATED DELIVERY: 2022
    PRE-LEASED: 0%                                                                                          PRE-LEASED: 0%
                                                                                                            TENANTS: N/A
    TENANTS: N/A
                                                                                                            DETAILS: The largest laboratory and office building currently underway along
    DETAILS: Initial phase of the Boston Flower Exchange redevelopment, which will span a                   Route 128. The building is situated among the suburbs’ largest cluster of life
    total of 1.6 MSF across 5.6 acres. The first phase will see the development of two buildings            science properties in Waltham.
    spanning 240,000 SF and 450,000 SF of laboratory and office use. Once completed, the
    project will also include 42,500 SF of retail space and 1,145 parking spaces.

                                       © NEWMARK KNIGHT FRANK | RESEARCH | 2020                    12                                             © NEWMARK KNIGHT FRANK | RESEARCH | 2020          12
BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
101 CambridgePark Dr, West Cambridge                                                         441 Morgan Ave - Cambridge Crossing, East Cambridge
10   DEVELOPER: Healthpeak Properties                                                        14   DEVELOPER: DivcoWest
     RENTABLE BUILDING AREA: 165,000 SF                                                           RENTABLE BUILDING AREA: 360,000 SF
     ESTIMATED DELIVERY: 2022                                                                     ESTIMATED DELIVERY: 2023
     PRE-LEASED: 0%                                                                               PRE-LEASED: 0%
     TENANTS: N/A                                                                                 TENANTS: N/A
     DETAILS: Proposed building situated next to the recently completed laboratory
     building at 35 CambridgePark Drive in Alewife. The building is steps from the MBTA           DETAILS: Also known as Parcel U, this is the final large-scale laboratory and office
     Alewife Redline station.                                                                     building planned at Cambridge Crossing. Construction and leasing efforts are currently
                                                                                                  focused on the development’s other three laboratory and office buildings underway.

     Nexus Phase I, Boston - Allston                                                              101 Smith Pl - The Quad, West Cambridge
11   DEVELOPER: King Street Properties
                                                                                             15   DEVELOPER: The Davis Companies
     RENTABLE BUILDING AREA: 340,000 SF                                                           RENTABLE BUILDING AREA: 100,000 SF
     ESTIMATED DELIVERY: 2022                                                                     ESTIMATED DELIVERY: 2023
     PRE-LEASED: 0%                                                                               PRE-LEASED: 0%
     TENANTS: N/A                                                                                 TENANTS: N/A
     DETAILS: First of two laboratory buildings to be constructed on several parcels along        DETAILS: Part of “The Quad” life science redevelopment underway in Alewife, which
     Western Avenue. At 340,000 SF, this building is the larger of the two and will rise          includes four new and redeveloped laboratory buildings. Two buildings have already
     seven stories. The building will include a small ground floor retail component along         undergone renovation at 75 Moulton Street and 10 Wilson Road, with new construction
     with 146 below-grade parking spaces.                                                         set to commence next at 101 Smith Place. 40 Smith Place will follow with roughly
                                                                                                  250,000 SF of new construction.

     XMBLY, Somerville
12   DEVELOPER: BioMed Realty
     RENTABLE BUILDING AREA: 976,000 SF (lab & office)
     ESTIMATED DELIVERY: 2023
     PRE-LEASED: 0%
     TENANTS: N/A
     DETAILS: Laboratory and office component of an approved 1.5 MSF mixed-use
     development next to Assembly Row. Includes an existing 162,000 SF office
     building and three planned laboratory, office and R&D buildings between 10 and
     19 stories in height.

     329 Northern Ave, Boston - Seaport District
13   DEVELOPER: Millennium Partners and Cargo Ventures
     RENTABLE BUILDING AREA: 381,000 SF
     ESTIMATED DELIVERY: 2023
     PRE-LEASED: 0%
     TENANTS: N/A
     DETAILS: Planned construction of a 10-story, 381,000 SF laboratory and office
     building at Raymond Flynn Marine Industrial Park. The development team had earlier
     last year proposed an innovation campus totaling 900,000 SF, but opted to scale
     back the project in favor of a shorter construction timeline.

                                                                                                                                        © NEWMARK KNIGHT FRANK | RESEARCH | 2020           14
BLOCKS BUILDING THE DNA OF LAB CONSTRUCTION
Nexus Phase II, Boston - Allston
                                                                                                   2
            8                                                                                          DEVELOPER: King Street Properties
                                                                                                       RENTABLE BUILDING AREA: 240,000 SF
                                                                                                       ESTIMATED DELIVERY: 2024
                         9
      2 1           64                                                                                 PRE-LEASED: 0%
                                                                                                       TENANTS: N/A
                                                                                                       DETAILS: Second of two laboratory buildings to be constructed on several parcels
                5                  3                                                                   along Western Avenue. At 240,000 SF, this building is the smaller of the two and will
                    7                                                                                  rise six stories at 305 Western Avenue. A six-story residential building with 40 units
                                                                                                       is also planned for the development and will provide 557 parking spaces for both
                                                                                                       residents and tenants.

                                                                                                       244-284 A St (P&G site), Boston - Seaport District
                                                                                                   3   DEVELOPER: Related Beal
                                                                                                       RENTABLE BUILDING AREA: 400,000 SF
                                                                                                       ESTIMATED DELIVERY: 2024
                                                                                                       PRE-LEASED: 0%
                                                                                                       TENANTS: N/A
                                                                                                       DETAILS: Laboratory component of a proposed 1.1 MSF mixed-use development along
                                                                                                       the Fort Point Channel. Formerly a surface parking lot owned by Procter & Gamble,
                                                                                                       the 6.5-acre site recently acquired by Related Beal will also include a 334,000 SF
                                                                                                       office building and a 366,000 SF residential building.

    2024 - BEYOND                                                                                  4
                                                                                                       585 Third St, East Cambridge
                                                                                                       DEVELOPER: BioMed Realty

    DEVELOPMENTS
                                                                                                       RENTABLE BUILDING AREA: TBD
                                                                                                       ESTIMATED DELIVERY: 2024
                                                                                                       PRE-LEASED: 0%
                                                                                                       TENANTS: N/A
                                                                                                       DETAILS: Proposed development of a .82-acre site located in the heart of Kendall
                                                                                                       Square. The project is proposed to include a mixed-use building including laboratory,
                                                                                                       office, residential, and performing arts space.

                Enterprise Research Campus, Boston - Allston
1               DEVELOPER: Breakthrough Properties
                RENTABLE BUILDING AREA: 400,000 SF (lab & office)
                ESTIMATED DELIVERY: 2024
                PRE-LEASED: 0%
                TENANTS: N/A
                DETAILS: Laboratory and office component of a 900,000 SF mixed-use development
                across 14.1 acres in Allston Landing. The development includes 400,000 SF of
                laboratory office space, 250,000 SF of hotel/conference center space, 250,000 SF
                of residential space, two public spaces, and 800 to 900 parking spaces.

                                                                                                                                             © NEWMARK KNIGHT FRANK | RESEARCH | 2020           16
Fenway Center Phase II, Boston - Fenway                                                           CambridgeSide Galleria Redevelopment, East Cambridge
5   DEVELOPER: Meredith Management and TH Real Estate
                                                                                                  9   DEVELOPER: New England Development
    RENTABLE BUILDING AREA: 720,000 SF                                                                RENTABLE BUILDING AREA: 1.0 MSF (est.)
    ESTIMATED DELIVERY: 2024                                                                          ESTIMATED DELIVERY: 2024+
    PRE-LEASED: 0%                                                                                    PRE-LEASED: 0%
    TENANTS: N/A                                                                                      TENANTS: N/A
    DETAILS: The second phase of Fenway Center will be constructed above the Mass Pike                DETAILS: Full-scale redevelopment of the CambridgeSide Galleria mall that will
    and Landsdowne Commuter Rail station and is expected to commence construction                     introduce office, laboratory, and residential uses. The project is approved for
    by the end of 2020 on a speculative basis. The project includes two laboratory and                575,000 SF of net new floor area, including 400,000 SF for commercial use.
    office buildings that will rise 10 and 20 stories each.

    Volpe Redevelopment, East Cambridge
6   DEVELOPER: MIT Investment Management Co.
    RENTABLE BUILDING AREA: 1.7 MSF
    ESTIMATED DELIVERY: 2024+
    PRE-LEASED: 0%
    TENANTS: N/A
    DETAILS: Redevelopment of the Volpe Transportation Center that recently commenced
    construction. MIT is first constructing a 400,000 SF office building for the USDOT and
    upon completion in late 2022, will begin developing roughly 1.7 MSF of commercial
    space including laboratory, office, retail and 1,400 housing units.

    200 Main St, East Cambridge
7   DEVELOPER: MIT Investment Management Co.
    RENTABLE BUILDING AREA: 400,000 SF
    ESTIMATED DELIVERY: 2024+
    PRE-LEASED: 0%
    TENANTS: N/A
    DETAILS: Part of MIT’s Kendall Square Initiative and located adjacent to the new
    laboratory building underway at 238 Main Street that is due for completion in
    mid-2021. A 13-story office and laboratory building is planned for the site, which is
    now home to a MIT student dormitory.

    1 Earle St - Boynton Yards Phase II, Somerville
8   DEVELOPER: DLJ Real Estate Capital Partners and Leggat McCall Properties
    RENTABLE BUILDING AREA: 600,000 SF (est.)
    ESTIMATED DELIVERY: 2024+
    PRE-LEASED: 0%
    TENANTS: N/A
    DETAILS: Second phase of the Boynton Yards development that will span more than
    1.0 MSF upon completion. The developer acquired an adjacent 3-acre parcel in 2019
    to expand the laboratory and office component of the development’s second phase,
    which initially proposed a building spanning 181,000 SF.

                                     © NEWMARK KNIGHT FRANK | RESEARCH | 2020                14                                             © NEWMARK KNIGHT FRANK | RESEARCH | 2020    18
5 FACTS OF LIFE
SCIENCE DEVELOPMENT                                                                       FIVE
                                                                                        LARGEST PLANNED          VOLPE CENTER
                                                                                         PROJECTS IN THE        REDEVELOPMENT
                                                                                            PIPELINE:             1,700,000 SF

                              1
                                                                                                                CAMBRIDGESIDE

                                        10.3       MSF
                                     OF LABORATORY SPACE
                                                                                4                           GALLERIA REDEVELOPMENT
                                                                                                                  1,000,000 SF
                                                                                                               XMBLY, SOMERVILLE
                                      WILL DELIVER IN THE                                                         976,000 SF
                                        NEXT FIVE YEARS           AN
                                                              ADDITIONAL                                   BOYNTON YARDS, SOMERVILLE
                                                            5.5 MSF COULD                                         875,000 SF
                                                              ENTER THE
                                                                                                             FENWAY CENTER PHASE II
                                                             PIPELINE BY
                                                                                                                  720,000 SF
                                                                 2025

              2           $275          /SF                                          TOP
                         AVERAGE LABORATORY                                      EMERGING
                            BUILD OUT COST                                      LIFE SCIENCE

                                                                            5     CLUSTER:

                                                                  3
                  URBAN
                FIT-OUT VS.
              CONSTRUCTION
                                                                                SEAPORT
*E XCLUDES
 LAND
                   COSTS
                                               17%
$1,000
                     *
                                                                                                 CURRENT
                     /SF                                                                        INVENTORY:
  LABORATORY                                               OF EAST                                1.1 MSF
   GROUND UP                                           CAMBRIDGE LAB
 CONSTRUCTION                                           INVENTORY IS                               2025
     COST                                             CURRENTLY UNDER                           INVENTORY:
                                                                                                  3.6 MSF
                                                       CONSTRUCTION

                                                                                                                   © NEWMARK KNIGHT FRANK | RESEARCH | 2020   20
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