2020 Annual Review - Alzheimer's Research UK

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2020 Annual Review - Alzheimer's Research UK
2020
Annual Review
2020 Annual Review - Alzheimer's Research UK
Alzheimer’s Research UK is
the UK’s leading dementia
                                      we
                                           £25.9                               we                                   we                                      we
research charity.
                                             million
We’re committed to
investigating the causes of
                                invested                                  enabled                             launched                                 brought
dementia and developing                in our charitable activities             scientists to publish a              our Early Detection of                  together 263 scientists
ways to prevent, diagnose,             including £21.1m in our                  record 268 research                  Neurodegenerative diseases              from across the world for
treat and, ultimately, cure            pioneering research                      papers, sharing important            (EDoN) initiative, aiming to            our very first virtual research
all forms of the condition.            programmes, over £1m                     discoveries with the global          pick up the diseases that cause         conference.
                                       more than in the previous                research community.                  dementia 10-15 years before
                                       12 months.                                                                    symptoms affect someone’s
Our year                                                                                                             day-to-day life.

in numbers                                                                                                                                                                                     Contents
Thanks to our incredible
                                                                                                                                                                                               04   Introduction
supporters, in 2019/20…                                                                                                                                                                        05   We fund
                                      we                                    we                                      we                                                                         07   We work collaboratively
                               partnered                              launched                                welcomed                                                                         08   We challenge
                                       with Alzheimer’s Society                 the third chapter of                 the government’s pledge to                                                10   You make it possible
                                       to deliver the Dementia                  our award-winning                    double funding for dementia
                                       Revolution campaign                      #ShareTheOrange                      research to £160m a year,                                                 14   Looking to the future
                                       through our Charity of the Year          campaign. Our film,                  publishing our ‘Delivering
                                       partnership for the Virgin Money         fronted by Hollywood                 the Dementia Moonshot’                                                    16   Our finances
                                       London Marathon. Reaching                superstar Samuel L.                  report to highlight the
                                       an incredible £4m, it was                Jackson, was watched                 research avenues that need                                                18   Our thanks
                                       the most successful Charity              6.5m times.                          urgent investment.
                                       of the Year partnership in the
                                       marathon’s 39-year history.

02   Alzheimer’s Research UK                                                                                                                                                                           Make Breakthroughs Possible   03
2020 Annual Review - Alzheimer's Research UK
Introduction from our Chairman and Chief Executive                                                                                                                                               We fund and deliver
With your support, we invested £25.9m in our charitable activities, including
£21.1m in our pioneering research programmes - more than ever before.
                                                                                                                                                                                                 pioneering research
This translated into more important discoveries, with Alzheimer’s Research UK funded             Many of our labs and study sites were closed for several months from March 2020,                Between April 2019 and March 2020 our supporters enabled
scientists publishing 268 research papers in 2019, sharing important new findings with
the research community around the world.
                                                                                                 meaning important projects were paused. But progress didn’t stop, with scientists
                                                                                                 focusing on the aspects of their roles that form the building blocks of successful research -
                                                                                                                                                                                                 us to commit £25.9m to our charitable activities. This
And this growing momentum was consistent with UK and global trends indicating the
                                                                                                 analysing data, designing experiments and writing up their findings.                            included investing £21.1m in groundbreaking research,
vitality of the dementia research sector before the COVID-19 outbreak. In 2019, there            Like most charities, our income for 20/21 has been significantly impacted and it’s right        supporting projects across all forms of dementia.
were more researchers tackling the condition than ever, and crucially, more cutting-edge         that we’re open about this impact. But you’ll also find plenty of reasons to be hopeful in
treatments in trial for the diseases that cause it too.                                          these pages. Thanks to the strong foundations you helped us build in 19/20, we are in the       Our scientists made more than                                And after analysing how 27,000 people played our
                                                                                                                                                                                                                                                              smartphone game Sea Hero Quest, scientists at the
These are heartening statistics that reflect the collective strength of will to end this awful
                                                                                                 best place to respond to the challenges COVID-19 has presented us as a charity.                 250 important discoveries, paving                            University of East Anglia discovered that adults who
condition once and for all.                                                                      From the launch of EDoN, our ambitious initiative focusing on the early detection               the way for new diagnostic tests,                            have an Alzheimer’s risk gene called APOE4 performed
                                                                                                                                                                                                                                                              worse on spatial navigation tasks than those without the
But we’re under no illusion – the months between the end of the 2020 financial year and
                                                                                                 of dementia-causing diseases, to the appointment of Prof Jonathan Schott as the                 preventions and treatments.                                  gene.
                                                                                                 charity’s first ever Chief Medical Officer and the third chapter of our award-winning
publishing this report have looked very different for everyone working to improve the lives                                                                                                      One highlight was the discovery that high or rising blood
                                                                                                 #ShareTheOrange campaign - there’s a great deal to celebrate.                                                                                                These are important findings as normal memory and
of people affected by dementia and for those living with the condition.                                                                                                                          pressure in midlife is linked to increased damage to
                                                                                                 The incredible support that made all this possible means we know we’ll come back                                                                             thinking tests could not distinguish between the two
                                                                                                                                                                                                 blood vessels in the brain, and smaller brain volumes at
Every walk of life has been touched by COVID-19, with people living with dementia and                                                                                                                                                                         groups, pointing to a role for technology like Sea Hero
                                                                                                 stronger than ever.                                                                             the age of 70 – both indicators of declining brain health.
their families one of the groups most acutely impacted. Barriers to families visiting loved                                                                                                                                                                   Quest in improving the way we diagnose dementia.
                                                                                                                                                                                                 This study has advanced our understanding of how risk
ones in care have caused immense heartache and potentially exacerbated symptoms,                 Thanks to you, no matter what the world throws at us, research will find a way.                 factors for heart health, including smoking and high
while vulnerabilities of people with dementia have meant that they are much more likely                                                                                                          blood pressure, affect the brain.
to experience serious complications or die from the virus.

                                                                                                  Hilary Evans		                David Mayhew CBE
                                                                                                  CHIEF EXECUTIVE 		            CHAIRMAN

                                                                                                                                                                                                 Sea Hero Quest gameplay
04   Alzheimer’s Research UK                                                                                                                                                                                                                                                               Make Breakthroughs Possible   05
2020 Annual Review - Alzheimer's Research UK
We work collaboratively
                                                                                                                                                                                                                                  to accelerate scientific progress
                                                                                                                                                                                                                                  We work with governments, funders, charities, the
                                                                                                                                                                                                                                  pharmaceutical industry, and people affected by
                                                                                                                                                                                                                                  dementia to bring about life-changing
                                                                                                                                                                                                                                  treatments as soon as possible.
                                                                                                                                                                                                                                  We’re making the case for                               We’re shaping future treatments.
                                                                                                                                                                                                                                  increased government funding.                           As we work towards the first life-changing dementia
                                                                                                                                                                                                                                  Dementia costs the UK economy £26bn a year, but         treatments, it’s essential that we fully understand the
                                                                                                                                                                                                                                  in 2017/18, government investment in dementia           aspects of daily life people would most want a new
                                                                                                                                                                                                                                  research was just £82.5m: 0.3% of the condition’s       treatment to preserve.
                                                                                                                                                                                                                                  enormous cost to society.                               We’re extremely grateful to the 5,800 people who
                                                                                                                                                                                                                                                                                          shared their views as part of our Shaping Future
                                                                                                                                                                                                                                  With the help of 1,200 of our supporters who wrote to   Treatments survey, developed with Prof Craig Ritchie
                                                                                                                                                                                                                                  their MPs, we’ve been calling for increased funding,    at the University of Edinburgh. The results will
We launched our Early Detection of Neurodegenerative                                      We held our first entirely virtual research conference.                                                                                 and we were delighted that in the 2019 election,
                                                                                                                                                                                                                                  the government pledged to launch a ‘Dementia
                                                                                                                                                                                                                                                                                          be used to help inform regulators and healthcare
diseases (EDoN) initiative to revolutionise the detection                                 As the COVID-19 pandemic took hold, we made the difficult decision to cancel our                                                        Moonshot’ to find a cure for dementia - doubling
                                                                                                                                                                                                                                                                                          decision makers who must assess the next generation
                                                                                                                                                                                                                                                                                          of dementia treatments.
of the diseases that cause dementia.                                                      annual Research Conference. Instead, we quickly adapted to host our very first virtual                                                  research funding and speeding up trials for new
Our ultimate ambition is to develop a cost-effective and non-invasive digital toolkit –
                                                                                          conference on Twitter to ensure vital new discoveries and projects were shared and
                                                                                          discussed, despite the strict lockdown. Over 260 scientists contributed to the event,
                                                                                                                                                                                                                                  treatments. In response, we published ‘Delivering the
                                                                                                                                                                                                                                  Dementia Moonshot’, identifying the most ambitious
                                                                                                                                                                                                                                                                                          We continue to learn from people
likely a combination of wearables and smartphone apps – to detect these changes. This     from those self-isolating in Boston Massachusetts, to those working from their homes                                                    and promising research where urgent investment is       affected by dementia.
would transform research efforts today, helping scientists to make faster breakthroughs   in Sheffield.                                                                                                                           needed. With your help, we’re continuing to hold the
in understanding these diseases and test potential new treatments far earlier, before                                                                                                                                                                                                     This year we formed a Policy Involvement Panel to
                                                                                                                                                                                                                                  government to account on this important promise.        bring people living with dementia, their carers, and
irreversible damage has been done.                                                        We pledged up to £36m to support our Drug Discovery                                                                                                                                             their loved ones much closer to our work to inform
We’re supporting the development of cutting-edge new                                      Alliance for a further five years.                                                                                                                                                              and influence government’s action on dementia.
medicines for Alzheimer’s disease.                                                        The Alliance links Drug Discovery Institutes at the Universities of Cambridge and Oxford
                                                                                                                                                                                                                                                                                          Panel members have already contributed to 10
                                                                                                                                                                                                                                                                                          different projects, including feeding into the
Though our investment in the Dementia Discovery Fund (DDF), we’re supporting              and University College London, with the goal of translating new findings from academic                                                                                                          development of the year’s key policy report -
AstronautX Ltd, a new UK-based biotech company, as it studies the role of brain cells     research into potential treatments as quickly as possible. Our support now enables the
                                                                                                                                                                                                                                                                                          ‘Delivering the Dementia Moonshot’.
called astrocytes. These cells play an essential role in keeping nerve cells working      Alliance to press on with critical drug discovery projects – with 16 ongoing projects
properly, but in Alzheimer’s disease, become harmful. The goal - to develop new           focusing on emerging new biological processes linked to dementia.
medicines designed to reset the damaging behaviour of these cells. We’re proud that                                                                                                  Rachel Riley presenting our ‘Just 1%’
four potential new drugs developed by companies receiving funding from the DDF                                                                                                       petition in May 2019. The petition,
are now in clinical trials, targeting Alzheimer’s disease, frontotemporal dementia and                                                                                               signed by nearly 35,000 people, called for
Parkinson’s disease.                                                                                                                                                                 government to increase annual funding for
                                                                                                                                                                                     dementia research to just 1% of the UK’s
                                                                                                                                                                                     yearly economic cost of dementia.
06   Alzheimer’s Research UK                                                                                                                                                                                                                                                                                              Make Breakthroughs Possible   07
2020 Annual Review - Alzheimer's Research UK
We challenge
the way people
think about
dementia

                                                                                         We’re providing accurate and                                  Our #ShareTheOrange campaign                                   We’re engaging the public with
                                                                                         accessible information about                                  is encouraging people to think                                 dementia research.
                                                                                         dementia to anyone who needs it.                              differently.                                                   Between April 2019 and March 2020, we met with
                                                                                         Through our Dementia Research Infoline, we offered            The third chapter of #ShareTheOrange, this time featuring      thousands of people at events of all types - from New
                                                                                         information and reassurance to more than 3,700 people         Hollywood superstar Samuel L. Jackson, showed how              Scientist Live to Green Man Festival - showcasing research
                                                                                         wanting to improve their understanding of dementia and        connections in the brain are threatened when dementia          and helping to change attitudes towards dementia.
                                                                                         research efforts to overcome it.                              takes hold, shining a light on the role research can play in
                                                                                                                                                       saving those vital connections.                                And we opened a brand new grant scheme called the
                                                                                         We distributed 195,000 free health information booklets                                                                      Inspire Fund, designed to bring new perspectives and
                                                                                         to households and communities across the UK, and              Chapter three was our most successful yet, with the            expertise to bear on our work to build understanding of
                                                                                         helped more than 1,800 people to register their interest in   campaign film watched 6.5m times across 105 different          dementia. Funded projects include an analysis of attitudes
                                                                                         taking part in research studies through the national Join     countries. And in an exciting first for the campaign, five     to dementia on social media using machine learning and
                                                                                         Dementia Research service.                                    landmarks across the UK, including the Blackpool Tower         a series of events supporting Chinese communities,
                                                                                                                                                       and Ely Cathedral were illuminated orange to mark World        aiming to tackle stigma and share information about
                                                                                                                                                       Alzheimer’s Day.                                               reducing risk.

                                                                                                 We’re expanding our reach in the media and online.
                                                                                                 Our work was featured in the news more than 8,000 times during the year, an increase of over 2,000
                                                                                                 mentions on the previous 12 months. The stories that attracted the greatest attention included:
                               Stigma and misunderstanding are still getting in the              The Dementia Revolution: Our collaboration with Alzheimer’s Society built
                                                                                                 around the 2019 Virgin Money London Marathon. Together, we generated 4,548
                                                                                                                                                                                      Good heart health in 20s linked to better brain health decades later:
                                                                                                                                                                                      After US scientists showed that better heart health in a person’s 20s leads to
                               way of progress. To reach our goal of a world free from           pieces of media coverage including slots on BBC Breakfast, Good Morning
                                                                                                 Britain and BBC Radio1. Polling found that one third of UK adults were aware of
                                                                                                                                                                                      better memory and thinking skills decades later, our Head of Research Dr Sara
                                                                                                                                                                                      Imarisio went on record to explain the link between the heart and the brain, and
                               the fear and heartache of dementia, we must first                 the campaign, with 46% of those saying it made them feel hopeful and 40%
                                                                                                 saying it made them feel positive about progress being made.
                                                                                                                                                                                      the steps we can take to keep both healthy.

                               change the conversation.
08   Alzheimer’s Research UK                                                                                                                                                                                                                         Make Breakthroughs Possible   09
2020 Annual Review - Alzheimer's Research UK
53,000 people now make monthly donations to support
                               our work, an increase of 10,000 people in just
                               12 months.
                               These amazing, committed supporters contribute a vital source of predictable income to
                               the charity.

You make
                               And we’re so grateful to the incredible 287 donors who left gifts in their Wills to support
                               dementia research. Legacy gifts totalled £13m in 2019/20 and made one in three of our
                               research projects possible.

it possible                    We have, once again, received astonishing levels of
                               support from our Corporate Partners.
We rely on the generosity      Our extraordinary Corporate Partners, including the Iceland Foods Charitable Foundation,
                               The Perfume Shop, Dyson and Ubisoft raised a fantastic £3.3m during the year.
of our supporters to carry     These generous companies and their employees also support our cause by contributing
                               vital skills and using their networks to amplify our awareness campaigns.
out our work and in
2019/20 we received            Our passionate supporters remain the backbone of
                               the charity.
an incredible £38m             More than 15,000 people chose to fundraise and volunteer for us in 2019/20, and did so
in donations.                  with the creativity, passion and sense of fun that defines our supporters.
                               A real highlight came on 28 April 2019, when 2,000 runners took on the Virgin Money
                               London Marathon in support of the Dementia Revolution – our joint campaign with
                               Alzheimer’s Society. Our Revolutionaries raised an incredible £4m to power projects at
                               the UK Dementia Research Institute, making this the most successful Charity of the
                               Year partnership in the marathon’s 39-year history.
                               And we celebrated a major milestone in our partnership with parkrun UK: a staggering
                               £1.5m raised. We’re delighted that so many parkrunners have got behind our cause,
                               taking part in campaigns including our award-winning virtual event, Running
                               Down Dementia.

                               We continue to be inspired by the generous support we
                               receive from philanthropists, trusts and foundations.
                               We were delighted to receive two seven-figure donations during the year, as well as a
                               crucial pledge from Bill Gates in support of our Early Detection of Neurodegenerative
                               diseases (EDoN) initiative.
                               And we established The Accelerate Club to bring together philanthropists interested in
                               supporting our Drug Discovery Institute at University College London. Six months in,
                               we’ve recruited 12 members to support the pioneering work taking place at the Institute.

10   Alzheimer’s Research UK                                                                                                 Make Breakthroughs Possible   11
2020 Annual Review - Alzheimer's Research UK
Anna Law is determined to play
                                her part in ending dementia once
 Protecting future              and for all, after witnessing the
                                impact of Alzheimer’s disease on                       “You can do far
 generations from               two generations of her family –
                                her grandfather and her mother.                        more than you
 the heartbreak                 She took on the 2019 Virgin Money London
                                Marathon as part of the Dementia Revolution and
                                                                                       think you can”
 of dementia                    has since pledged to leave a gift in her Will.

                                “It’s such a difficult thing to go through. You lose
                                the person that you love. Though the changes
                                to my mum’s memory have been slow, it’s still
                                been hard. She forgets things we take for granted
                                like turning the oven off when she has finished
                                cooking and remembering where she is – she
                                often gets lost.

                                Last year, I ran the London Marathon to raise
                                money for dementia research, and I’m thrilled
                                that more than £4m was raised!

                                I firmly believe that we will advance our
                                knowledge of dementia through research. In my
                                own lifetime, I have seen how science can change
                                lives and I take hope for the future.                  Andrew Ross, a 60-year-old occasional                         The climb was really tough but the beautiful scenery
                                                                                                                                                     helped.
                                                 That’s why I’m leaving a gift to      cyclist, planned his epic fundraising                         There was an enormous feeling of satisfaction on
                                                   Alzheimer’s Research UK in my       challenge after witnessing the                                completing our toughest days, and of course when
                                                    Will - so other families won’t
                                                      have to go through what
                                                                                       devastating impact of dementia on his                         crossing the finishing line in Corfu.
                                                      mine has been through.”          wife’s mother in the final years of her                       We raised over £300,000 which was double our initial
                                                                                                                                                     target and incredibly satisfying for us. We monitored our
                                                                                       life and on her family and loved ones                         fundraising as we rode and it was a real inspiration for
                                                                                       around her.                                                   everyone to keep going.
                                                                                                                                                     If there’s one thing I think we’ve proved, it’s that if you
                                                                                       “Last year, we put together an event called ‘Cycle2Corfu’,    put your mind to it, you can do far more than you think
                                                                                       which saw us cycling almost 2,000km from the UK to            you can.”
                                                                                       Greece to raise funds for dementia research. There were
                                                                                       a lot of highs but the biggest of all was probably crossing
                                                                                       the Alps.

012
 12   Alzheimer’s Research UK                                                                                                                                                                                      Make Breakthroughs Possible   013
                                                                                                                                                                                                                                                  13
2020 Annual Review - Alzheimer's Research UK
Our Early Detection of Neurodegenerative diseases
                                                                                                                                     (EDoN) initiative will be a priority. We look forward to
                                                                                                                                     working with research volunteers as we start to collect
                                                                                                                                     data, and with our partners to develop cutting-edge
                                                                                                                                     digital approaches to spot the early warning signs of the
                                                                                                                                     diseases that cause dementia.
                                                                                                                                     We will work to ensure that the urgently-needed injection
                                                                                                                                     of funding pledged by government is delivered, and that
                                                                                                                                     funds are directed to the research that will make the
                                                                                                                                     greatest difference.
                                                                                                                                     In response to evidence suggesting that up to 40% of
                                                                                                                                     cases of dementia are linked to risk factors that we may

                               Looking to                                                                                            be able to influence, we will launch a new campaign to
                                                                                                                                     celebrate everything our brains do for us and empower
                                                                                                                                     people to take positive steps to protect their brain health.

                               the future
                               We made important progress in
                               2019/20, funding more vital research     We expect a sharp drop in income and, with it, a
                               than ever before. But there’s a great    reduction in the amount we can invest in research.
                                                                        Although we have already postponed some planned
                               deal left to do, and the enormous        projects, we’re safeguarding crucial areas of our work and
                               impact of the COVID-19 pandemic          we remain committed to our mission.
                               means the months between the             There’s still a great deal to look forward to and we take
                               end of the 2020 financial year and       inspiration from the development of the COVID-19
                                                                        vaccines, which demonstrate what we can achieve
                               publishing this report have looked       through research.
                               very different for us and for everyone
                                                                        In the coming year, we will continue our long-term
                               working to end dementia.                 support for four major research initiatives designed         As virtual fundraising events will be more important
                                                                        to accelerate progress towards new treatments - the          than ever, we will find new and exciting ways to connect
                                                                        Dementia Consortium, our Drug Discovery Alliance,            supporters online. The Mighty Quiz will enable anyone to
                                                                        the Dementia Discovery Fund and the UK Dementia              challenge their friends and family, and power dementia
                                                                        Research Institute. And we will continue to fund more        research from the comfort of their own living room. And
                                                                        than 110 ongoing research grants directed by leading         our new virtual triathlon, The Treble Challenge, will give
                                                                        researchers across the UK, from Pilot Projects to Research   supporters the freedom to run, cycle and swim at a time
                                                                        Fellowships.                                                 and place of their choosing.

14   Alzheimer’s Research UK                                                                                                                                                                        Make Breakthroughs Possible   15
2020 Annual Review - Alzheimer's Research UK
Thanks to our amazing supporters, we invested £25.9m in our charitable
                                activities in 2019/20, including £21.1m in our research programmes.                                                                                                                                                                                  Our promise to you
  Our finances                  This is over £1m more than in the previous 12 months.
                                                                                                                                                                                                                                                                                     We depend on the generosity of you, our supporters, to fund our pioneering research programmes.
                                How do we use your donations?                                                                                                                                                                                                                        In return, we promise to:

                                        For every £1 donated
                                                                                                                                                                                                                                                                                         Spend your money wisely                                             Treat you fairly                                                Protect your information
                                        • 72p powered our research and helped people to understand and take                                                                                                                                                                              Only investing in the highest quality research and                  Keeping you informed by demonstrating the                       Taking all necessary steps to keep your data safe.
                                         action on dementia.                                                                                                                                                                                                                             continually looking for ways to reduce costs and                    progress that your donations are helping to fuel.               We’ll never sell, rent or share your information with
                                                                                                                                                                                                                                                                                         run the charity more efficiently, including the use                 And we won’t present anything in a way that could               external organisations for their benefit.
                                        • 28p helped to raise the next £1 and fund essential running costs.                                                                                                                                                                              of volunteers wherever possible.                                    be misinterpreted, whether in reports like this one,            More information at
                                                                                                                                                                                                                                                                                                                                                             on our website or on the phone.                                 alzheimersresearchuk.org/privacy-policy
                                        These figures differ from the 2019 figures (77p and 23p) as a result of fewer fundraising
                                        events taking place towards the end of the financial year and the uncertainty in our operating
                                        environment caused by the onset of the COVID-19 pandemic.
                                        In response to this uncertainty, we made the tough decision not to take on new research
                                        commitments, to ensure we could continue to fund existing research programmes.
                                                                                                                                                                                                                                                                                     Find out more
                                                                                                                                                                                                                                                                                     The following resources provide further information about dementia and the activity covered in this Annual Review.

                                Our income

                                                                                                                                                                                                                                                    2020 Annual Report
                                 Income from                                                                                             Amount
                                Voluntary donations                                                                                 £37,979,783
                                                                                                                                             Visit www.alzheimersresearchuk.org to find out more.

                                                                                                                                             Alzheimer’s Research UK
                                Income from charitable activities

                                                                                                                                                                                                                                                      www.alzheimersresearchuk.org
                                                                                                                                         £989,753
                                                                                                                                            is the UK’s leading dementia
                                                                                                                                             research charity.
                                                                                                                                                                                                                                                                                                   Annual Report
                                Other trading and income generating activities                                                           £454,029                                                                                                                                                    and Financial Statements

                                Investment income                                                                                        £868,844

                                Net income in joint venture operations                                                                   £534,056
                                                                                                                                             3 Riverside, Granta Park, Cambridge. CB21 6AD T: 0300 111 5333 E: enquiries@alzheimersresearchuk.org

                                Total                                                                                              £40,826,465
                                                                                                                                             Registered charity numbers: 1077089 and SC042474

                                                                                                                                                                                                                                                                                     Full 2019/20 Annual                        Early Detection of                   Delivering the Dementia              #ShareTheOrange                       An introduction to
                                Our expenditure                                                                                                                                                                                                                                      Report                                     Neurodegenerative                    Moonshot                               Too many people still think         dementia
                                                                                                                                                                                                                                                                                     For a more detailed picture of our         diseases (EDoN)                      We’ve called on government to          dementia is a natural part of       Our ‘Quick guide to dementia’,
                                 Our expenditure                                                                                         Amount                                                                                                                                      work and progress made during the          With a wealth of digital data at     invest in six priority research areas, ageing. To help change that, and    available in English and seven
                                                                                                                                                                                                                                                                                     last financial year, please read our       our fingertips, now is the time to   which will help to deliver a life-     to improve understanding of the     other languages, provides the
                                Charitable activities                                                                               £25,872,641                                                                                                                                      Annual Report:                             transform the early detection of     changing treatment for dementia. diseases that cause dementia,             basic facts about dementia in
                                                                                                                                                                                                                                                                                     alzres.uk/annual-reports                   the diseases that cause dementia.    Here’s our delivery plan:              please share our film about         easy-to-understand terms:
                                Cost of generating funds                                                                            £13,898,126
                                                                                                                                                                                                                                                                                                                                Learn more about our game-           alzres.uk/moonshot-report              an orange:                          alzres.uk/quick-guides
                                                                                                                                                                                                                                                                                                                                changing EDoN initiative:                                                   alzres.uk/orange
                                Total                                                                                              £39,770,767
                                                                                                                                                                                                                                                                                                                                edon-initiative.org
016
 16   Alzheimer’s Research UK                                                                                                                                                                                                                                                                                                                                                                                                                           Make Breakthroughs Possible   017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       17
2020 Annual Review - Alzheimer's Research UK
Thank you                                                                           George and Alison Cornwall-Legh -
                                                                                     Indian Summer Ball
                                                                                                                         Neil Berkett
                                                                                                                         Odgers Berndtson
                                                                                                                                                              The Harebell Centenary Fund
                                                                                                                                                              The Ingram Trust
                                                                                                                                                              The James Dyson Foundation
                                                                                                                                                                                                     Donald Weedon, in memory of Jean
                                                                                                                                                                                                     Weedon
                                                                                                                                                                                                     Doreen Cairns
                                                                                     George and Martha Back                                                                                          Dr Sheila Mitchell
 We would like to thank every one of the                                                                                 Peacock Charitable Trust             The Jordan Charitable Foundation
                                                                                     Guy & Anne Morton                   Peter Dixon Charitable Trust                                                Dr Michael P Reece
 thousands of people across the country                                              Hidden Hearing
                                                                                                                                                              The Laurence Misener Charitable
                                                                                                                         PF Charitable Trust                  Trust                                  Eileen Barritt-Smith
 who have supported us in 2019/20.                                                   Houghton Dunn Charitable Trust      Philip King Charitable Trust         The Lyons Charitable Trust             Eileen Worthington
 Your donations, however big or small, are driving                                   J Macdonald Menzies Charitable                                           The Murdoch Forrest Charitable Trust   Eleanor James
 research that will transform the lives of people
                                                                                                                         Rahul Moodgal
                                                                                     Trust                                                                    The Nielsen Family, in memory of       Elizabeth Brie
 with dementia. Thank you for believing in the                                                                           Reed Smith LLP
                                                                                     John Lebus, in memory of Penelope                                        David Hague                            Evelyn Romans
 power of research. These people and
                                                                                     Lebus                               Royal Cromer Golf Club
 organisations have made an exceptional                                                                                  Saffron Barker & Ross Scrivener      The Nigel Scott Will Trust             Geoffrey Clarke                    Thank you to our Pioneers’             Thank you to our Accelerate
 contribution to our work:                                                           Julian & Jenny Cazalet                                                                                                                                                                    Club members:
                                               Carol Franklin-Adams                                                      Schroders Personal Wealth            The Olsher family                      Helen Boslem                       Circle members:
                                                                                     Karen Penny                                                              The Park Family Charitable Trust
                                               Caroline van den Brul, in memory of                                       Scott Mitchell & Dame Barbara                                               Isobel Fleming Hamilton            David Barnett                          Andrew Balls & Erica Wax
                                                                                     Ken Sunter                                                               The R S Macdonald Charitable Trust
                                               David Hague                                                               Windsor                                                                     Jeanette Lovecchio                                                        Andrew Shilston
                                                                                     Kiltwalk, Sir Tom Hunter & The                                                                                                                     David Mayhew CBE
 Andrew Ross & Cycle2Corfu                     CarTakeBack.com                                                           Simmons & Simmons LLP                The Revere Charitable Trust            Joan Gell
                                                                                     Hunter Foundation                                                                                                                                  Denise Coates Foundation               David A Lewis & Susan J Lewis
 Annabel Drabble and Louise Willis             Christopher Carter                                                        Sir Arnold Burgen, FRS               The Saintbury Trust                    Joy Raison
                                                                                     Kohler Mira                                                                                                                                        Financial Times                        David Barnett
 ARUK Aberdeen Fundraising Group               Clive Watson and Mary Hayes                                               Sir David Ord                        The Samworth Foundation                Judith Frattini
                                                                                     Lavenham Trust                                                                                                                                     Goldman Sachs                          Edward & Lesley Lambourne
 ARUK Huddersfield Fundraising                 CMS                                                                       Stella Donoghue & Jim O’Donovan      The Sinclair Charity                   June Broadbridge
                                                                                     Lazard                                                                                                                                             Iceland Foods Charitable Foundation    Jan Hall OBE
 Group                                         Convex Insurance UK                                                       Team Fox: Adrian Spieler, Cindy      The Steel Charitable Trust             Kenneth Godfrey
                                                                                     Legal & General Group plc                                                                                                                          parkrun UK                             Robert and Jill Le Blanc Charitable
 ARUK Shropshire Fundraising Group             David & Ruth Lewis Family                                                 Henderson, Adrienne Rossouw and      The Symondson Family Charitable        Leo Summers                                                               Trust
                                                                                     Lewis Silkin LLP                    Tania Creavalle                      Trust                                                                     Pat and Jimmy Hamilton
 Augusta Charitable Trust                      Charitable Trust                                                                                                                                      Lilian Kaziu                                                              Stephen Catlin
                                                                                     Liz McGill                          The Bliss Family Charity             The Zochonis Charitable Trust                                             Race Against Dementia
 BigHand                                       David Roper                                                                                                                                           Margaret Bland                                                            Tim Oliver
                                                                                     Lord & Lady Fink                    The Bradley and Katherine Wickens    Tom Attwood                                                               Ricoh Europe Plc
 Bloomberg LP                                  Development Bank of Wales & FW                                                                                                                        Marion McKernan
                                               Capital                               Lord Dolar Popat                    Foundation                           Ubisoft                                                                   Sir KS Li - Li Ka Shing Foundation
 Briggs Equipment                                                                    Margaret Giffen Charitable Trust    The Cadogan Charity                                                         Meriel Hancock
                                               Diligenta Limited                                                                                              Veolia UK                                                                 The ALBORADA Trust
                                                                                     Masonic Charitable Foundation       The Carr-Gregory Trust                                                      Molly Thorne                       The Joseph and Lilian Sully
                                               Dilys Linstead, in memory of Roger                                                                             Withers LLP
                                               Linstead                              Mattioli Woods plc                  The Classic, Silverstone                                                    Paddy Dewey                        Foundation
                                               Dirk & Thea Lievens-Chiarini          Mayfair Capital                     The Connolly Foundation (UK)                                                Paul Dolan                         The Lyndal Tree Foundation
                                                                                                                                                              Thank you to everyone who
                                               Enid Lymer, in memory of Alan Gray    Mike Macdonald and Jonathan         Limited                                                                     Peggy & Paul Walker                The Michael Bishop Foundation
                                                                                                                                                              remembered us through a gift
                                               ERA Total Security                    Lamley                              The Constance Travis Charitable      in their Will, including:              Peter & Mary Glen                  The Mike Gooley Trailfinders Charity
                                                                                     Miss Bridget Catherine Johnson      Trust                                                                       Richard Longfield                  The Perfume Shop
                                               Fred Walker
                                                                                     Charitable Trust                    The Cowies                           Albert Edward Anderton                 Ron Smith                          The Rainwater Charitable Foundation
                                                                                     Mr and Mrs Alan Howard              The de Laszlo Foundation             Andrew Burt                            Sheila Savage                      The Rt Hon David Cameron
                                                                                     Mr Daniel E Pinto                   The Eric and Margaret Kinder         Andy Watson                            Stanley Busby                      The Syncona Foundation
                                                                                                                         Charitable Trust                     Barbara Johnson                        Violet Lovatt                      Virgin Money
                                                                                                                         The Fieldrose Charitable Trust       Barbara Partridge
 We would like to thank all those who have                                                                                                                                                           Walter Harwoood                    Wickes
                                                                                                                         The Fordham Family Charitable Fund   Brenda Anthony
 donated and chosen to remain anonymous.                                                                                                                                                             William Prince
                                                                                                                                                              David Greenwood

018
 18   Alzheimer’s Research UK                                                                                                                                                                                                                                                               Make Breakthroughs Possible   019
                                                                                                                                                                                                                                                                                                                           19
Alzheimer’s Research UK is
the UK’s leading dementia
research charity.
Visit www.alzheimersresearchuk.org to find out more.

                          3 Riverside, Granta Park, Cambridge. CB21 6AD
                          T: 0300 111 5333 E: enquiries@alzheimersresearchuk.org
                          Registered charity numbers: 1077089 and SC042474
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