Zoetis Equine Deworming Portfolio Overview for Veterinarians - 2020 Zoetis Equine Dental Wellness Survey
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2020 Zoetis Equine
Dental Wellness Survey
Zoetis Equine Deworming Portfolio
Overview for Veterinarians
20201 Campaign Kick-Off
January 24, 2020
2021
AAEP Parasite Control Guidelines
2
Source: https://aaep.org/sites/default/files/Documents/InternalParasiteGuidelinesFinal5.23.19.pdf
Key Take-Aways: ADULT HORSES • Baseline recommendation for ALL adult horses is 1-2 dewormings/year: – Early Grazing Season: target small strongyles – End of Grazing Season: target small strongyles + tapeworms – Effective treatment of encysted small strongyles is imperative • FEC testing recommended to identify high shedders which may need 1-2 additional small strongyle treatments during peak grazing season • There is clear loss of larvicidal efficacy against small strongyles in five-day double- dose fenbendazole (Panacur® Powerpac) • AAEP says moxidectin is the treatment of choice against small strongyles 3
QUEST® VS. PANACUR® POWERPAC
RESEARCH CONFIRMS:
• One tube of QUEST Gel controls small
strongyles in a single dose (99.5% FECRT)
vs. five double-doses of fenbendazole
(Panacur® Powerpac) (42% FECT)1
• Resistance to fenbendazole (Panacur
PowerPac) in the U.S. is widespread1
• QUEST (moxidectin) remains effective for
controlling the most common equine
parasites1
4
1 Mason ME, Voris ND, Ortis HA, Geeding AA, Kaplan RM. Comparison of a single dose of moxidectin and a five-day course of fenbendazole
to reduce and suppress cyathostomin fecal egg counts
in a herd of embryo transfer-recipient mares. J Am Vet Med Assoc 2014;245.
MOXIDECTIN AND IVERMECTIN ARE NOT THE SAME
• Moxidectin – the primary active ingredient in QUEST® Gel and QUEST® PLUS Gel – treats the
dangerous encysted form of small strongyles. Ivermectin does not.1
• There is NO GENERIC form of QUEST Gel or QUEST PLUS Gel
≠
5 QUEST Gel or QUEST PLUS Gel in foals less than 6 months of age or in sick, debilitated and underweight horses.
Do not use
These products should not be used in other animal species, as severe adverse reactions, including fatalities in dogs, may result.
Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.
1 AAEP Parasite Control Guidelines 2019, p.3
Key Take-Aways: FOALS & YOUNG HORSES • Foals need 4-5 deworming treatments within their first 12 months of life. • Ascarids are still the parasite of primary concern in foals, especially through weaning/approximately 6 months of age. • FEC testing should be conducted at weaning to monitor when the foal’s primary target parasite shifts from ascarids to strongyles. • 1–2-year-old horses should be treated like high-shedding adult horses: – Early Grazing Season: target small strongyles – Mid/Peak Grazing Season: target small strongyles – End of Grazing Season: target small strongyles + tapeworms 6 – Effective treatment of encysted small strongyles is imperative
UPDATED ZOETIS EQUINE DEWORMER POSITIONING 7
Updated Zoetis Equine Dewormer Positioning Our Goal: • Prioritize what’s best for the health of horses • Update our dewormer guidance to reflect the current reality of parasite resistance • Do our part to mitigate additional parasite resistance to dewormers, for the long- term health of all horses 8
Key Reminders
• For adult horses, the AAEP Guidelines recommend a baseline treatment of
1-2 deworming administrations per year, regardless of FEC status
• Parasites of focus in adult horses are small strongyles and tapeworms
• Moxidectin is the “treatment of choice” for small strongyles and is the only
anthelmintic to address encysted small strongyles in a single dose
• Timing recommended for adult horses: beginning of grazing season and end
of grazing season (when there is peak parasite exposure)
• Parasite of focus in young foals is ascarids (roundworms)
• Foals
9
need 4-5 deworming treatments during their first 12 months of life
(transitioning to a focus on strongyle treatment around weaning)
Updated Focus: Horse Life Stage 10
Adult Horses: Baseline Treatments for All
The AAEP Parasite
Control Guidelines1
recommend treating
all adult horses 1-2
times per year
11
1 https://aaep.org/sites/default/files/Documents/InternalParasiteGuidelinesFinal5.23.19.pdfAdult Horses: Identifying High Shedders
Utilize FEC testing
to identify those
high shedders that
need more than the
2x year baseline
treatment for small
strongyles
12Adult Horses 13
1–2-Year-Olds
The AAEP Parasite
Control Guidelines1
recommend treating
1–2-year-old horses
like adult high
shedders
14
1 https://aaep.org/sites/default/files/Documents/InternalParasiteGuidelinesFinal5.23.19.pdfFoals 15
APPENDIX
QUEST® Gel
(moxidectin)
• Treats adult and encysted larval stages of small strongyles, the key parasite of
concern in adult horses
• Also treats large strongyles (adult and migrating larvae), bots, pinworms,
hairworms, and habronema (stomach worms)
• Recommended for adult horses in early grazing season and for targeting
strongyles in young horses above 7 months of age
• Demonstrated safe for use in a variety of horses
• Approved for breeding mares and stallions
• One syringe treats up to 1,500 lb
• Unique gel formula dissolves quickly on the tongue for easy administration
17
Do not use QUEST Gel or QUEST PLUS Gel in foals less than 6 months of age or in sick, debilitated and underweight horses.
These products should not be used in other animal species, as severe adverse reactions, including fatalities in dogs, may result.
Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.QUEST® PLUS Gel
(moxidectin + praziquantel)
• Treats adult and encysted larval stages of small strongyles, the key parasite of
concern in adult horses
• Also treats tapeworms, large strongyles (adult and migrating larvae), bots,
pinworms, hairworms, and habronema (stomach worms)
• Recommended for adult horses in end of grazing season and for targeting
strongyles and tapeworms in young horses above 7 months of age
• One syringe treats up to 1,500 lb
• Unique gel formula dissolves quickly on the tongue for easy administration
18
Do not use QUEST Gel or QUEST PLUS Gel in foals less than 6 months of age or in sick, debilitated and underweight horses.
These products should not be used in other animal species, as severe adverse reactions, including fatalities in dogs, may result.
Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.ANTHELCIDE® EQ Paste (oxibendazole)
• Ideal for targeting ascarids (roundworms) in young foals
• Also approved to treat large strongyles, pinworms, and threadworms
• Only use to target small strongyles if verified still effective through Fecal Egg
Count Reduction Test (FECRT) on individual farms
• One syringes treats up to 1,200 lbs
19
Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.STRONGID® Paste (pyrantel pamoate)
• Ideal for targeting ascarids (roundworms) in young foals
• Also approved to treat large strongyles, and pinworms
• Only use to target small strongyles if verified still effective through Fecal Egg
Count Reduction Test (FECRT) on individual farms
• One syringes treats up to 1,200 lbs
20
Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.STRONGID C 2X (pyrantel tartrate)
How it Works
• Helps prevent large strongyle bloodworm larval infestations and control adult
large strongyles, as well as adult and fourth-stage larvae of small strongyles,
pinworms and roundworms
• Palatable pellets for easy daily administration
Target Horses
• High shedders and horses at high risk for parasite infections
• High-risk age groups such as foals, weanlings and geriatric horses
Reminders
• “Purge” treat with appropriate paste/gel dewormer targeting small strongyles
prior to starting daily dewormer
• Target tapeworms with a praziquantel treatment at the end of grazing season
21
Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.AAEP Parasite Control Guidelines – Key Points
• No fundamental changes
– FEC surveillance continues to be core recommendation
– Small Strongyles (cyathostomins) and tapeworms continue to be parasites of concern
“…all adult horses should benefit from a basic foundation of one or two treatments
per year. Low strongyle egg shedding hoses with naturally strong immunity to
cyathostomins will need no other treatments because the two treatments have Consider Quest Gel
covered the needs of the other parasites and these horses are generally protected or Quest Plus Gel
naturally from disease caused by cyathostomins by their immune state. In traditional
deworming programs, repeated treatment of low shedder horses every 2-3 months
accomplishes little to improve their health, but it does promote drug resistance.
Moderate and high shedders will need a third and sometimes a fourth treatment for
cyathostomins…”
“Any additional treatments would be given on an ‘as needed’ basis depending on
whether a specific parasite infection or disease is diagnosed…”
22
Source: https://aaep.org/sites/default/files/Documents/InternalParasiteGuidelinesFinal5.23.19.pdfAAEP Parasite Control Guidelines – Key Points
• Consider treating most adult horses for 2 key parasites of concern 2x/year:
➢ Small strongyles (Spring)
➢ Small strongyles + tapeworms (Fall)
• Treating encysted small strongyles is another important consideration
“Considerations for mature horses: Focus on control of
cyathostomins [small strongyles]. Depending on climatic Consider Quest Gel
conditions, one or two yearly treatments are sufficient to or Quest Plus Gel
prevent occurrence of large strongyles. Consider including a
treatment effective against encysted cyathostomins at a time
when the mucosal burden is at its peak. Typically, this is more
likely to occur towards the end of the grazing season, i.e., fall
in northern climates, and spring in the more tropical and
subtropical climates.” Consider Quest Plus Gel
“Include
23 a cestocide at least annually if they are a problem in
your region.”
Source: https://aaep.org/sites/default/files/Documents/InternalParasiteGuidelinesFinal5.23.19.pdfAAEP Parasite Control Guidelines – Key Points
• Small Strongyles
– Moxidectin = treatment of choice vs. 5-day double-dose fenbendazole
– Moxidectin treats encysted form
“Two recent blinded anthelmintic efficacy studies performed in the U.S. with
two different equine populations have documented a clear loss of larvicidal
efficacy and the five-day double-dose fenbendazole regimen, whereas
moxidectin had intact larvicidal efficacy in both studies… Given the
widespread occurrence of benzimidazole resistance in cyathostomin
parasites across the world moxidectin would be the treatment of choice in a
large majority of locations.”
24 Consider Quest Gel or Quest Plus Gel
Source: https://aaep.org/sites/default/files/Documents/InternalParasiteGuidelinesFinal5.23.19.pdfAAEP Parasite Control Guidelines – Key Points
• Tapeworm treatment recommendation
“Because tapeworms are relatively common and widely distributed, have a strong
seasonality of transmission, have potential to cause disease, and are difficult to
diagnose, it is likely that a properly timed single annual tapeworm treatment would be
beneficial for most horses. Even if this treatment is not needed for the health of an
individual horse, a properly timed annual treatment given to all horses on a property
should diminish transmission the following grazing season. However, there is no
evidence that frequent tapeworm treatments throughout the year would provide any
additional health benefit. Drug choices for treatment of tapeworms include
praziquantel (licensed in the US for horses only in combination with ivermectin or
moxidectin), or a cestocidal (double the nematode dose) of pyrantel pamoate. In most
areas, this treatment should be given in the late fall or early winter after tapeworm
transmission ends due to cold weather…”
25
Consider Quest Plus Gel
Source: https://aaep.org/sites/default/files/Documents/InternalParasiteGuidelinesFinal5.23.19.pdfAAEP Parasite Control Guidelines – Key Points
Consider
• Treatment considerations for foals/weanlings/yearlings Anthelcide EQ and
Strongid Paste for
“During the first year of life foals should receive a minimum of four ascarid treatments
anthelmintic treatments. First deworming should be carried out at about 2-3 in young foals
months of age, and a benzimidazole drug is recommended to ensure efficacy
against ascarids. Second deworming is recommended just before weaning
(approximately 4-6 months of age). An extra treatment can be justified before
weaning if the time period between the two treatments exceeds 3 months. At
weaning, FECs are recommended to determine whether worm burdens are
primarily strongyles or ascarids, to facilitate the right choice of drug class.
Third and fourth treatments should be considered at about 9 and 12 months
of age, respectively, and treatment should primarily be targeting strongyles.
In areas, where tapeworms are present, a tapeworm-directed treatment
should be included in the 9-month treatment, or before the end of the first
calendar
26 year.”
Consider Quest Plus Gel for 9 month treatment
Source: https://aaep.org/sites/default/files/Documents/InternalParasiteGuidelinesFinal5.23.19.pdfConsult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. Panacur is a registered trademark of Merck Animal Health. ©2021 Zoetis Services LLC. All rights reserved. QST-00176
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