Update on COVID-19 Projections - Science Advisory and Modelling Consensus Tables September 28, 2021
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Key Findings • New cases, hospitalisations and ICU occupancy are not increasing. There is a wide range for case projections, reflecting the fragile situation and high degree of instability as colder weather approaches with more time indoors. • Continued control over case growth requires high vaccination rates in the eligible population, continued public health measures, and a flattening of growth in mobility. • The risk of contracting COVID-19, being hospitalized for COVID-19, and entering the ICU is several times higher for unvaccinated individuals. • Vaccination coverage is increasing slowly. • Post COVID-19 Condition – or Long COVID – will substantially impact the health of thousands of Ontarians 2
Weekly new cases per 100,000 residents 100 110 10 20 30 40 50 60 70 80 90 0 Data source: CCM Chatham-Kent Wellington-Dufferin-Guelph Eastern Ottawa Southwestern Lambton Waterloo Halton Peterborough Haldimand-Norfolk Huron Perth Sudbury 14-day increases Haliburton KPR Leeds Grenville Lanark KFLA Algoma September 7 Grey Bruce Northwestern Renfrew Data note: Data for the most recent day have been censored to account for reporting delays Windsor-Essex Average weekly cases on: Brant Hamilton September 20 Niagara Peel York Cases are increasing in 19 of 34 public health units Toronto Middlesex-London Durham Simcoe Muskoka Hastings & PEC North Bay Parry Sound 14-day decreases Porcupine Thunder Bay Timiskaming
Testing episodes per 1,000 (7-day avg.) 0 1 2 3 4 5 6 7 Aug 1 Aug 15 Aug 29 Sep 12 Sep 26 Oct 10 Oct 24 Nov 7 Data source:OLIS via SAS VA, data up to September 17 Nov 21 Dec 5 Dec 19 Jan 2 Jan 16 Jan 30 Feb 13 Feb 27 Mar 13 Specimen Date Mar 27 Apr 10 Apr 24 May 8 May 22 Jun 5 Jun 19 Jul 3 Jul 17 Jul 31 Aug 14 Aug 28 Sep 11 With the start of school, testing rates are up across Ontario Ontario, 2 Timiskaming, 1 Chatham-Kent, 3
Test positivity appears to be declining 18 % positivity of daily testing episodes 16 14 12 (7-day avg.) 10 8 6 Chatham-Kent, 4.9% 4 Windsor, 4.2% Brant, 4.0% Ontario, 2.7% 2 0 Aug 15 Aug 29 Aug 14 Aug 28 Oct 10 Oct 24 Jun 19 Jun 5 Nov 21 Nov 7 Apr 10 Apr 24 Jan 16 Jan 30 Jul 17 Jul 31 Aug 1 Jul 3 Feb 13 Feb 27 Dec 19 Sep 12 Sep 26 Mar 13 Mar 27 Sep 11 May 22 Jan 2 May 8 Dec 5 Specimen Date Data source:OLIS via SAS VA, data up to September 17 The most recent 3 days have been removed to account for incomplete data.
Vaccination coverage is increasing slowly Analysis: Secretariat of the Science Advisory Table (https://covid19-sciencetable.ca/ontario-dashboard/) 6 Data: https://data.ontario.ca/
Vaccination continues to be highly effective Unvaccinated people have a 7-fold higher risk of symptomatic COVID-19 disease, a 25-fold higher risk of being in the hospital and 60-fold higher risk of being in the ICU compared to the fully vaccinated Analysis: Secretariat of the Science Advisory Table (https://covid19-sciencetable.ca/ontario-dashboard/) 7 Data: https://data.ontario.ca/ and CCM plus; estimates of patients in hospital and ICU are age standardized
Our 4th wave has flattened due to continued public health measures and vaccination but cases in children are increasing MOBILITY - Analysis: Secretariat of the Science Advisory Table (https://covid19-sciencetable.ca/ontario-dashboard/) Data: 8 https://data.ontario.ca/ & https://ourworldindata.org/explorers/coronavirus-data-explorer CASES BY AGE - Analysis: PHO, Data: CCM
There is a wide range for case projections, reflecting the fragile situation and high degree of instability as colder weather approaches. Figure shows predictions PREDICTED 6,000 based on a consensus across 5,000 models from 5 scientific teams. 4,000 Range from High uncertainty in estimates last briefing Daily Cases because: 3,000 • Uncertainty in vaccine effectiveness against 2,000 infection • Too early to see impact of 1,000 increased contacts with return to school and - 2021-04-01 2021-05-01 2021-06-01 2021-07-01 2021-08-01 2021-09-01 2021-10-01 2021-11-01 workplaces ON - Daily ON - 7-Day Average • Seasonality and time spent High Trajectory (25%↑ in Transmission) Status Quo (no change in behaviour or policy) indoors vs. outdoors Low Trajectory (25%↓ in Transmission) Predictions informed by modeling from Fields Institute, McMasterU, PHO, WesternU, YorkU 9 Data (Observed Cases): covid-19.ontario.ca
ICU Occupancy estimates vary from under 200 beds to over 300 beds by the end of October PREDICTED 1,000 900 800 700 ICU Occupancy 600 500 Range from 400 last briefing 300 200 100 - 21 1 21 8 21 5 21 2 21 9 21 6 21 3 21 0 21 7 21 3 21 0 21 7 21 4 21 1 21 8 21 5 21 2 21 9 21 5 21 2 21 9 21 6 21 2 21 9 21 6 21 3 21 0 21 7 21 4 21 1 28 0 0 1 2 2 0 1 2 2 0 1 1 2 0 0 1 2 2 0 1 1 2 0 0 1 2 3 0 1 2 4- 4- 4- 4- 4- 5- 5- 5- 5- 6- 6- 6- 6- 7- 7- 7- 7- 7- 8- 8- 8- 8- 9- 9- 9- 9- 9- 0- 0- 0- 0- -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -0 -1 -1 -1 -1 21 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 ON - Daily ON - 7-Day Average High Trajectory (25%↑ in Transmission) Status Quo (no change in behaviour or policy) Low Trajectory (25%↓ in Transmission) Predictions: COVID-19 ModCollab based on case predictions in previous slide.. 10 Data (Observed ICU Occupancy): CCSO
The 4th wave continues to put pressure on hospital capacity in a number of jurisdictions COVID-19 Patients in Hospital Analysis: Secretariat of the Science Advisory Table 11 Data: https://data.ontario.ca/, https://resources-covid19canada.hub.arcgis.com and https://ourworldindata.org/explorers/coronavirus-data-explorer
However, in Ontario hospital and ICU occupancy have been stable for several weeks 2,500 Patients in ICU with COVID-related critical illness 2,000 Patients in inpatient beds (incl. ICU) with active COVID19 COVID inpatient and ICU total census 1,500 1,000 500 0 01-Sep-20 01-Oct-20 01-Nov-20 01-Dec-20 01-Jan-21 01-Feb-21 01-Mar-21 01-Apr-21 01-May-21 01-Jun-21 01-Jul-21 01-Aug-21 01-Sep-21 12
Long-term predictions: High risk of rapid increase in ICU occupancy can be reduced with a cautious approach and early contact reductions. 40 Example: London-Middlesex, predicted ICU occupancy for a population of 500,000. 35 30 25 ICU Occupancy 20 15 10 5 0 2021-04-01 2021-05-01 2021-06-01 2021-07-01 2021-08-01 2021-09-01 2021-10-01 2021-11-01 2021-12-01 2022-01-01 Actual (Local demand only) 80% of pre-pandemic contacts 70% of pre-pandemic contacts Modelled to Sept 15 • Scenarios shown assume that as ICU occupancy and deaths increase, contacts will decrease due to behaviour change and implementation of public health measures • Summer (Step 3) contacts approx. 82.5% compared to pre-pandemic contacts • If scaling up to Ontario population, ICU occupancy predictions for Ontario would be expected to be higher and the peak to occur earlier, especially in large urban areas. Predictions: WesternU 13
Patients in ICU are expected to be younger compared to earlier waves. Example: London-Middlesex, predicted ICU occupancy for a population of 500,000. 40 Scenario: 80% of pre-pandemic contacts + behaviour change as ICU occupancy and deaths increase + 35 current estimates of vaccine effectiveness. 30 25 ICU Occupancy 20 15 10 5 0 Sep-01 Oct-01 Nov-01 Dec-01 Jan-01 Feb-01 Mar-01 Apr-01 May-01 Jun-01 Jul-01 Aug-01 Sep-01 Oct-01 Nov-01 Dec-01 Jan-01 Under 12 years 12-17 years 50-59 years • Summer (Step 3) contact level approx. 82.5% 18-24 years 60-69 years • If scaling up to Ontario population, ICU occupancy predictions for Ontario would be 25-49 years Over 70 years expected to be higher and the peak to occur earlier, especially in large urban areas. Predictions: WesternU 14
Post COVID-19 Condition – or Long COVID – will substantially impact the health of thousands of Ontarians • About 1 in 10 individuals with COVID-19 infection will continue to have symptoms lasting more than 12 weeks (estimated 57,000 to 78,000 individuals in Ontario based on data up to August 2021) • Most common symptoms: fatigue, shortness of breath, pain, anxiety and depression, trouble thinking/concentrating (“brain fog”) • Can impact individuals of any age or baseline health, and can occur even if minimal to no symptoms during initial infection • Vaccines are strongly protective: • Reduce the chance of getting infected by about 85% • Reduce the chance of developing Long COVID-19 in breakthrough infections by about 50%
Post COVID-19 Condition may substantially impact the health system Post COVID-19 Condition may result in significant burden on individuals, healthcare system and society: • Increased incidence of new chronic disease (e.g., diabetes or cardiovascular disease) • Higher healthcare utilization (physician visits, hospitalization) • Severe impairment of home-life and day to day activities for some individuals • Longest follow-up study (12 months after infection): • 12% of all infected individuals had not returned to work • Among the 88% who returned, 24% had not returned to their pre-COVID-19 level of work
Key Findings • New cases, hospitalisations and ICU occupancy are not increasing. There is a wide range for case projections, reflecting the fragile situation and high degree of instability as colder weather approaches with more time indoors. • Continued control over case growth requires high vaccination rates in the eligible population, continued public health measures, and a flattening of growth in mobility. • The risk of contracting COVID-19, being hospitalized for COVID-19, and entering the ICU is several times higher for unvaccinated individuals. • Vaccination coverage is increasing slowly. • Post COVID-19 Condition – or Long COVID – will substantially impact the health of thousands of Ontarians 17
Contributors • COVID-19 Modeling Collaborative: Kali Barrett, Stephen Mac, David Naimark, Aysegul Erman, Yasin Khan, Raphael Ximenes, Sharmistha Mishra, Beate Sander • Fields Institute: Taha Jaffar, Kumar Murty • McMasterU: Irena Papst, Michael Li, Ben Bolker, Jonathan Dushoff, David Earn • Modeling Consensus Table: Isha Berry • PHO: Kevin Brown, Sarah Buchan, Alyssa Parpia • Science Advisory Table: Peter Juni, Kali Barrett, Karen Born, Nicolas Bodmer, Shujun Yan • Western University/London Health Sciences Centre : Lauren Cipriano, Wael Haddara • YorkU: Jianhong Wu, Yanyu Xiao, Zack McCarthy 18
Content and review by Modelling Consensus and Scientific Advisory Table members and secretariat Beate Sander,* Peter Juni, Brian Schwartz,* Kumar Murty,* Upton Allen, Vanessa Allen, Kali Barrett, Nicolas Bodmer, Isaac Bogoch, Karen Born, Kevin Brown, Sarah Buchan, Yoojin Choi, Troy Day, Laura Desveaux, David Earn, Gerald Evans, Jennifer Gibson, Anna Greenberg, Anne Hayes,* Michael Hillmer, Jessica Hopkins, Jeff Kwong, Fiona Kouyoumdjian, Audrey Laporte, John Lavis, Gerald Lebovic, Brian Lewis, Linda Mah, Kamil Malikov, Doug Manuel, Roisin McElroy, Allison McGeer, David McKeown, John McLaughlin, Sharmistha Mishra, Andrew Morris, Samira Mubareka, Laveena Munshi, Christopher Mushquash, Ayodele Odutayo, Shahla Oskooei, Menaka Pai, Alyssa Parpia, Samir Patel, Anna Perkhun, Bill Praamsma, Justin Presseau, Fahad Razak, Rob Reid,* Paula Rochon, Laura Rosella, Michael Schull, Arjumand Siddiqi, Chris Simpson, Arthur Slutsky, Janet Smylie, Robert Steiner, Ashleigh Tuite, Jennifer Walker, Tania Watts, Ashini Weerasinghe, Scott Weese, Xiaolin Wei, Jianhong Wu, Diana Yan, Emre Yurga * Chairs of Scientific Advisory, Evidence Synthesis, and Modelling Consensus Tables For table membership and profiles, please visit the About and Partners pages on the Science Advisory Table website. 19
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