Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.

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Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
Toward the Next Growth Phase

Shigeo Taniuchi
President and CEO
Santen Pharmaceutical Co., Ltd.

J.P. Morgan Healthcare Conference
January 11, 2021

Copyright© 2021 Santen All rights reserved.   1
Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
Forward-Looking Statements
     Information given in this presentation contains certain forward-looking statements concerning forecasts, projections and
      plans whose realization is subject to risk and uncertainty from a variety of sources. Actual results may differ significantly
      from forecasts.
     Business performance and financial condition are subject to the effects of medical regulatory changes made by the
      governments of Japan and other nations concerning medical insurance, drug pricing and other systems, and to fluctuations
      in market variables such as interest rates and foreign exchange rates.
     The process of drug research and development from discovery to final approval and sales is long, complex and uncertain.
      Individual compounds are subject to a multitude of uncertainties, including the termination of clinical development at
      various stages and the non-approval of products after a regulatory filing has been submitted. Forecasts and projections
      concerning new products take into account assumptions concerning the development pipelines of other companies and
      any co-promotion agreements, existing or planned. The success or failure of such agreements could affect business
      performance and financial condition significantly.
     Business performance and financial conditions could be affected significantly by a substantial drop in sales of a major drug,
      either currently marketed or expected to be launched, due to termination of sales as a result of factors such as patent
      expiry and complications, product defects or unforeseen side effects. Santen also sells numerous products under sales and
      / or manufacturing license from other companies. Business performance could be affected significantly by changes in the
      terms and conditions of agreements and/or the non-renewal of agreements.
     Santen is reliant on specific companies for supplies of certain raw materials used in production. Business performance
      could be affected significantly by the suspension or termination of supplies of such raw materials if such an event were to
      adversely affect supply capabilities for related final products.

Copyright© 2021 Santen All rights reserved.                                                                                     2
Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
The World is Built on the Ability to See

Copyright© 2021 Santen All rights reserved.   3
Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
CORE PRINCIPLE and WORLD VISION

    CORE
  PRINCIPLE
                                               “Exploring the secrets and mechanisms of nature in order to contribute to
                                               people’s health” *

      WORLD                                    Happiness with Vision
      VISION                                   The Happiest Life for every individual, through the Best Vision Experience

   * Santen’s original interpretation of a passage from the Zhongyong (The Doctrine of the Mean) by Confucius.

 Copyright© 2021 Santen All rights reserved.                                                                        4
Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
Strategy Framework: Toward 2030
Aim to resolve social issues through
expansion of solutions in ophthalmology

                                               Ophthalmology
                                                    Wellness

                                                        Inclusion

 Copyright© 2021 Santen All rights reserved.               5
Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
Challenge of Diversification in Ophthalmology
Expanding business scope for further growth as a specialized company

         Geography coverage                                                                        Technology
                                               Americas
                                                      EMEA                                    New modality
                                                         Asia                           Small molecules
                                                             China                   Device
                                                                  Japan        Digital

                        Inclusion                                    Diagnosis

                                                                     Treatment
                                                                  (reimbursement)

                                                                     Treatment
                                                                   (out of pocket)

                                                                     Wellness
                                                Value Offerings
 Copyright© 2021 Santen All rights reserved.                                                                    6
Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
Challenge of Diversification in Ophthalmology
Expanding business scope for further growth as a specialized company

         Geography coverage                                                                 Technology
                                               Americas
                                                     EMEA                              New modality
                                                        Asia                        Small molecules
                                                          China                  Device
                                                             Japan         Digital

                                                                                 Business
                        Inclusion                                  Diagnosis
                                                                                  domain
                                                                Treatment
                                                             (reimbursement)
                                                                 Treatment
                                                               (out of pocket)

                                                                   Wellness
                                                 Value Offerings
 Copyright© 2021 Santen All rights reserved.                                                             7
Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
Expanding Solutions in Ophthalmology
   Enter new modality, device and digital domains while also enhancing core expertise

                                    Digital          Device   Small Molecules     New Modality

Check-up
Diagnosis
Follow-up

                                  Device                       Enhancement        Expansion of
Treatment
(Reimbursement)               commercialization               of core business   pharmaceutical
                                                                                    business

Treatment
(Out of Pocket)

Wellness

       Copyright© 2021 Santen All rights reserved.                                         8
Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
Expanding Solutions in Ophthalmology
   Expansion of portfolio through active partnerships

                                    Digital          Device                  Small Molecules                         New Modality

Check-up                                                     Support                           Glaucoma
                                                         ophthalmologists’
Diagnosis                           Digital                  training                      treatment support
Follow-up                           device
                                                                                                                  Gene therapy

                                  Device                                     Enhancement                           Expansion of
Treatment
(Reimbursement)               commercialization                             of core business                      pharmaceutical
                                Glaucoma device                               ROCK
                                                                                                                     business
                                                                             inhibitor                            Cell therapy
                                          IOL

Treatment                              Approach to                                        Myopia progression
(Out of Pocket)                          myopia                    Ptosis                reduction for children

Wellness

       Copyright© 2021 Santen All rights reserved.                                                                               9
Toward the Next Growth Phase - Shigeo Taniuchi President and CEO Santen Pharmaceutical Co., Ltd.
Santen’s Global Presence
Robust revenue driven by business expansions outside Japan

                                                     Overseas
                                                    CAGR*1:17%                       Japan                                             China
                                         China                      Exceed market growth                                Double-digit growth
                                          9% Asia
                                                                    Market share of approx.                             Market share No.1*2
                                               7%
                               FY2019
                             Consolidated
                                                                                 50%         *2

                               Revenue          EMEA
                                                 15%
                             241.6             Americas
                Japan        Billion yen                                               Asia                                           EMEA
                                                 0%
                68%                                                     Double-digit growth                          Exceed market growth
                                                                        Market share No.2*2                         Securing top 5 position*2,3

   Japan                                                   *1: FY2010-2019 CAGR
                                                           *2: Copyright © 2020 IQVIA. JPM 2019.10–2020.9 and
 CAGR*1:7%                                                     IQVIA MIDAS 2019; Santen analysis based on IQVIA data. Reprinted with permission
                                                           *3: Excluding anti-VEGF

 Copyright© 2021 Santen All rights reserved.                                                                                                      10
Unleashing Our Strengths
Contributing to the development of ophthalmology by combining our specialized
knowledge with external expertise and technology
        Partnership/                                              Product
    Product development                                           supply

                  Global                                    Communication with
                 platform                                ophthalmology stakeholders

 Copyright© 2021 Santen All rights reserved.                                11
Our Plan to Enter the United States
Eyevance acquisition and DE-128 aimed at developing a future revenue pillar

  Pipeline in the US                                   As of October 2020
                                                                              Acquisition of
                                                                            commercial platform
                                               DE-128
                                               (Application filed)

 Glaucoma                                      DE-117 (P3)
                                                                              45+               5+
                                               DE-126 (P2b)                 Field forces   Unique FOTE
                                                                                            products
 Vernal                                        Verkazia
 keratoconjunctivitis                          (Application filed)
                                                                             Exclusive US sales partner
 Uveitis                                       DE-109 (P3)                        for MicroShunt

 Copyright© 2021 Santen All rights reserved.                                                          12
Our Vision for Future Growth
Aim to increase corporate value by further strengthening existing geographies,
entering the US market, and new business

                                                                   New business

                                                                         US

                                                     Existing business in
                                                     Japan, China, Asia, EMEA

                                                                        2030
 Copyright© 2021 Santen All rights reserved.                                  13
Our Diversity and Inclusion
Promoting D&I to enhance corporate value over the mid-to-long term

 Diversification of talented
                                                                    “Blind Experience”
     human resources

                                                  The global movement putting disability on
                                                  the business leadership agenda.

 Copyright© 2021 Santen All rights reserved.                                           14
Happiness with Vision

Copyright© 2021 Santen All rights reserved.    15
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