The Good Fight - Nordic Semiconductor
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Issue 2, 2020 DAMAGE CONTROL: CELLULAR TRACKING IDENTIFIES WHO PAYS FOR MISHANDLED GOODS FULL STEAM AHEAD: EDUCATING THE CODERS OF THE FUTURE SPECIAL REPORT The Good Fight The vital wireless tech helping front line staff in the war against COVID-19 WIRELESS SURFING BUT CELLULAR CERTIFICATION A NEW LANGUAGE FOR NOT AS YOU KNOW IT GAINS MOMENTUM IoT PROGRAMMING
Contents News News Extra 3 7 Welcome Svenn-Tore Larsen CEO News The latest developments from Nordic Semiconductor Global certification Sports & Fitness M SPECIAL REPORT: COVID-19 Bluetooth LE electric y previous welcome column in Wireless Quarter Feature The Good Fight 8 recognized the despair coronavirus and the disease it causes, COVID-19, brought to the world. The pandemic is Customers board allows surfers Wireless tech is helping beat the spread of COVID-19 a once-in-a-lifetime event that is still far from over - but there are have taken some encouraging signs that we might be getting the upper hand. to ride above water CaseStudy 12 Nordic’s Smart thermometers And even at the lowest point there were some heartwarming detect virus symptoms things to raise spirits. For example, the world’s essential technology Analysis 15 workers— in healthcare, transport, the emergency services and and turned it A Melbourne, Australia-based technology company has designed a How wireless tech can benefit many others—showed remarkable courage to keep us safe, and into impressive remote-controlled electric board that allows watersport enthusiasts a post-pandemic world engineers and scientists from many countries have collaborated products at an to ride on any body of water with a depth of at least one meter up to fight coronavirus in a global effort the like of which we have to speeds of 45 kph. Feature unprecedented The Fliteboard system, designed by Tekt Industries, comprises a Tracking In, Privacy Out 16 rarely seen before. Contact tracing means trading pace to fight 6 kW brushless electric motor-powered hydrofoil (“eFoil”) board, as Early in the crisis it was suggested that electronics technology personal freedom for safety COVID-19 well as the Flite Controller remote handset. Both the board and might help in tackling and then controlling coronavirus. That has the handset integrate a Rigado Bluetooth LE module based on Fliteboard creates a similar feel to kite- or turned out to be true; the semiconductor industry in particular Nordic’s nRF52832 SoC. wind-surfing Full STEAM Ahead 18 has played a very significant role in this global endeavor, and The handset relays control data to the board via low latency Wireless educational tech electronics engineers have embraced wireless tech to accelerate Bluetooth LE connectivity, enabling the rider to wirelessly control the helps kids develop coding skills speed of the motor, even when both devices are submerged in water. The companion app can be used to download session data and provide the effort. I see evidence of this all around in the way our Bidirectional Bluetooth LE connectivity also allows the handset to a visual representation of the session using a map view and various Damage Control 22 customers have taken Nordic’s technology and turned it into receive key data from the board itself—such as telemetry and battery icons including tilt and roll angles, speed, and battery status. The Who pays for goods damaged in impressive products at an unprecedented pace. These wireless status—then display the information on the integrated screen. rider can also use the app to share the rides and upload the content transit is a billion dollar question products have particularly helped with tracking outbreaks, The board’s fully sealed subassembly is embedded directly into to the Cloud. monitoring the symptoms of patients and assisting healthcare the carbon fiber shell and provides GPS data recording, motion “The Fliteboard allows its rider to ‘surf’ on the water whether it Nordic Inside 26 measurement, telemetry transport and data transfer hardwired to be by the beach or on a lake without wind but creates a similar feel Carv ski trainer staff manage hygiene. Other applications include contact tracing the main eFoil module. As well as connecting the board to the handset, to kite- or wind-surfing,” says Matthew Adams, CEO of Tekt to inform people if anyone they’ve been near is later diagnosed the Bluetooth LE link enables the board to communicate with the Industries. “It’s easy to learn, even for the first time rider, and it’s fast, Tech Zone News 28 with COVID-19. And once coronavirus is under control we will need accompanying iOS-compatible Flite App on the user’s smartphone. quiet and emission free.” Tech Briefing 29 wireless tech to keep us safe ahead of any vaccination program. A new language for Cortex-M This edition’s special report brings you up-to-date on how programming Nordic’s technology is being used to fight today’s crisis and how it Sensor delivers Smart City Tech Perspective End-device certified 30 will help us tomorrow. Continue to stay safe. maintenance alerts Cellular IoT solution modems ease cellular IoT design IIoT company, Lynxemi, has launched its streamlines power Nordic Product Summary 32 Vibration and Temperature Sensor platform, which provides reliable sensor data for grid operations predictive maintenance of machines. The sensor integrates a MEMS U.S. design agency, Apricity, is helping power accelerometer as well as a temperature utilities avoid relying on polluting auxiliary sensor to capture data such as temperature power stations to meet prime time demand. and vibration performance of electrical The company’s Apricity Ara cellular IoT continues to be controlled by the utility. Wireless Quarter is published on behalf of Nordic Semiconductor by Ecritech motors. A Nordic nRF52840 SoC enables the and wireless mesh domestic water heater “In the U.S. tanked water heaters are often www.ecritech.tech device to relay periodic performance reports controller employs a Nordic nRF9160 SiP and installed as always-on devices with no user- Editor as well as anomalous measurement alerts to nRF52840 SoC and is attached inline with or demand-based control and as such Steven Keeping sk@ecritech.tech The Bluetooth ® word mark and logos are maintenance personnel via Bluetooth LE. the power supply of each water heater. This the units continually consume energy registered trademarks owned by the Bluetooth Assistant Editor SIG, Inc. and any use of such marks by Nordic Wireless connectivity is supported by allows the heater to be controlled remotely reheating the water,” explains Apricity COO, Semiconductor is under license. Chris Williams cw@ecritech.tech MQTT—a simple and lightweight network by the local power utility using the LTE-M Jacob C Betcher. © Nordic Semiconductor 2020 protocol, designed for constrained version of cellular IoT wireless technology. “During times of peak demand, asking Production Editor Andrew Woolls-King awk@ecritech.tech devices—running over Bluetooth LE. As some water heaters are in areas with dormant hot water heaters to temporarily Creative Director Complete data samples and system poor LTE-M coverage, Apricity also needed reduce their energy consumption is a very Sam Grimmer alerts are relayed from the to support the solution with a back up effective power load reducing method. With Image Editors sensor to a gateway for proprietary wireless mesh. some simple local monitoring, it is possible Nathan Sargent, Neale Hobday Subscribe @NordicTweets Like us Follow us Forum: devzone. nordicsemi.com additional processing, and The solution allows any Ara unit with no to allow water heaters in use to continue Print & Distribution then to the Cloud for later cellular service to communicate with any heating, while reducing standby heating of Printech Europe To subscribe to WQ visit www.nordicsemi.com/wqmag deeper analysis. other Ara that has good cellular reception and those water heaters not in use,” adds Betcher. 2 W Issue 2 2020 Issue 2 2020 W 3
News In Brief Logistics & Transport Wearables NORDIC JOINS UN COVID-19 CHALLENGE Smart home delivery box eliminates Wearable makes healthy food Nordic Semiconductor has joined forces with human contact in COVID-19 fight choices based on user’s DNA the United Nations Developer Program as well as Hackster.io to call on developers, product A smart home delivery box developed by U.K.-based DnaNudge has released a the device determine if the designers, scientists, hackers, makers and Homeboxx allows for safe a Norwegian startup of the same name, deliveries outside of peak new wristworn wearable dubbed the food is suitable for them innovators to come together and develop Homeboxx, could become a useful tool in the hours and in poor weather DnaBand, enabling users to make food based on their unique connected solutions to help slow or prevent battle against COVID-19. choices aligned with their DNA. genetic traits. For the spread of COVID-19 in developing Homeboxx employs a Nordic cellular IoT After a one-time cheek swab test example, if an individual countries. As part of the effort Nordic is nRF9160 SiP to allow confirmation of all that analyzes and maps the user’s has a high sensitivity giving away free development kits for its successful deliveries by NB-IoT with both genetic profile and key traits, the to sugar, saturated fat nRF52840 SoC to people registering online. the delivery company and consumer. It also results are loaded onto a capsule or salt, and scans the allows deliveries to be made without any that can be worn as “digital barcode on a product need for contact between the consumer and DNA” on the wrist, as part of the with high levels of these ENERGY HARVESTING FOR delivery driver, thus supporting overnight DnaBand wearable. ingredients, the DnaBand and SMART SENSORS deliveries at a time when the demand for The device is powered by Insight smartphone app will notify A team led by Penn State scientists have online grocery shopping far outstrips SiP’s ISP1507-AX RF module them, and steer them towards a developed a method of harvesting wasted supply in most countries due to social which employs Nordic’s nRF52832 healthier alternative. magnetic energy and converting it into distancing guidelines. Bluetooth LE SoC. The chip provides Once the barcode is scanned, the enough electricity to power next-generation “We’ve long recognized that the next the wireless connectivity to the device’s LED display will flash either green, to sensor networks for smart buildings and evolutionary step in online shopping required user’s smartphone. indicate a suitable food choice, or red, to indicate factories. The device is said to provide 400 percent higher power output compared to a much smarter ‘last mile’ delivery solution From the DnaNudge smartphone app, the a choice less well matched to their DNA profile. other technology when working with low- than relying on consumers to be home to user can scan the barcodes of approximately When the wearable is also used to monitor the level magnetic fields. The researchers said the receive their goods or taking the risk of home this can result in food being left on In operation, each delivery is assigned half a million food products and instantly have user’s activity, an amber LED indicates that a technology had implications for the design leaving items outside where they could doorsteps where it can spoil, especially in a unique code that is then used to both scanned product that might usually be suitable of smart buildings, which could benefit from be stolen or damaged by bad weather,” countries with extreme temperature climates track the item during shipping and to allow is not recommended because of the wearer’s self-powered wireless sensor networks. explains Karl-Einar Jensen, Founder & Board such as Norway.” the delivery driver to gain access to the level of activity. Director of Homeboxx. Homeboxx is claimed to eliminate these Homeboxx. Sensors within the Homeboxx From the app the user can also view their “This is hindering the growth of online problems by providing a thermally isolated detect the exact date and time its lid was genetic report, view their scan history and SOUTHEAST ASIA shopping because it forces delivery (basic battery-powered model) or climatically opened, as well as the ambient temperature lists of alternative product recommendations, EXPANSION FOR NORDIC companies to deliver only during the day controlled (advanced mains-powered model) in the box. This data is then sent to both the as well as nominate specific ingredients they A new sales, marketing at peak traffic periods,” says Jensen. “For environment to store deliveries that do not delivery company and consumer to confirm would like to avoid to assist the device in and customer support groceries in particular, if the consumer is not rely on consumers being home. successful delivery was made. improving product choices. office for Southeast Asia will allow Nordic to provide faster customer Internet of Things Plug and play NB-IoT platform By the Numbers support to the region’s rapidly expanding wireless design and Sensor-to-Cloud speeds product development $70.2 25 manufacturing sectors. The new office based billion in Sydney, will service Australia, New Zealand, IoT platform Singapore, Thailand, Vietnam, Indonesia, Malaysia and the Philippines. Wendell Boyd, Leading German IoT solution provider supports over-the- Regional Sales Manager for ASEAN and ANZ, million by 2025 Embedded design consultant, Signetik, has grandcentrix–now part of Vodafone– air updates and GPS unveiled a precertified, battery powered cellular IoT module platform called SigCell. The platform offers basic and big data AI has released the low cost Cellular Twin NB-IoT platform, which enables product manufacturers to transfer telemetry and functionality. Four digital inputs, four analog inputs (0-10 V) and two digital outputs IoT connections will head up the office, while Engineering support for Nordic’s ASEAN and ANZ customers will continue to be serviced from Nordic’s established Asian HQ in Hong Kong. analysis and machine learning capabilities. usage data to the Cloud. are available on the interface to cover most The company says the SigCell platform offers a range of environmental sensing and image processing capabilities including temperature, humidity, movement, sound, The hardware of Cellular Twin is a compact, standardized mainboard with optional expansion modules. The product turns almost any existing product into a smart IoT device common industrial applications. Simple analog sensors and digital buttons as well as more complex interfaces such as TTL-UART can also be connected. in revenue IoT connections will reach almost 25 billion globally by 2025, up from 12 billion in 2019, according to a DISTRIBUTION AGREEMENT OPENS UP TURKEY Nordic Semiconductor has reported Q1 2020 new report by the GSMA. Enterprise IoT connections Nordic Semiconductor has signed a light, rain, gun shot and visual tracking. by adding it to a network. This includes all “We designed Cellular Twin to be simple revenue of $70.2 million, representing growth of will overtake those in the consumer sector in 2024, distribution agreement with Özdisan Typical battery life is quoted at two to five required IT, hardware and built in connectivity and secure while supporting low cost, high 33.5 percent over Q1 2019. The result comes on and will almost triple between 2019 and 2025 to Elektronik, an Istanbul, Turkey-based years depending on duty cycle. all the way up to native Microsoft Azure IoT volume adoption in the widest range of the back of a continued strong market position reach 13.3 billion. This will account for just over components distributor specializing in The platform uses Nordic’s nRF9160 SiP’s support and compatibility with all other products and applications,” says Fabian in Bluetooth LE, which represented 73 percent half of all IoT connections in 2025, according to electronics hardware and software design, 64MHz Arm Cortex-M33 processor to major IoT Cloud platforms via secure https and Kochem, the Cellular Twin Product Manager of total revenue during the quarter. Cellular IoT is the GSMA study. Consumer IoT connections will and RF technical support for IoT developers. perform sensor data MQTT communications. at grandcentrix. “Most of our customers will still in the early stages of commercialization with almost double to 11.4 billion in the same time frame. The deal covers distribution and design acquisition and edge The mainboard is connected to a product have working prototypes within a few weeks reported revenue of $1.1 million in Q1 2020. This was According to the report, IoT is forecast to generate support for Nordic’s entire portfolio of low computing to avoid the controller via a 15-pin interface and to test and assess, and can expect to go into an increase from $0.1 million on Q1 2019 and $0.2 revenues of $1.1 trillion in 2025, compared to $3.43 power cellular IoT and short range wireless cost of sending large establishes a secure connection to Vodafone’s volume production at anywhere between 100 million from last quarter, reflecting a shift in sales billion in 2019. The report says that smart buildings solutions. Özdisan Elektronik employs 205 amounts of data to global NB-IoT cellular network via the thousand and tens of millions of units in as from mainly development kits to initial sales for will be the largest growth sector, in particular members of staff across the country. the Cloud. integrated Nordic nRF9160 SiP, which also little as six to nine months.” end user products. lighting, HVAC systems, security and automation. 4 W Issue 2 2020 Issue 2 2020 W 5
News Smart Health News Extra Home testing wearable helps doctors diagnose sleep apnea Global Belgian medical technology startup, stops temporarily while asleep. As this forces certification maintains Ectosense, has launched a battery powered them to wake up, it prevents sufferers from home sleep testing wearable dubbed getting a good night’s sleep. NightOwl. Following the closure of sleep The optical sensor is supported by an labs around the world due to COVID-19, the company claims the sleep monitor is providing doctors with results just as accurate, but at a accelerometer that can be used to pause monitoring to conserve battery power if the wearer wakes up and starts moving momentum fraction of the inpatient costs. about during a typical eight-to-ten Australia’s 4G operator Telstra joins The NightOwl comes in two versions—either hour night analysis period. an advanced rechargeable device or a ten- Collected data is continuously Deutsche Telekom, Verizon and Vodafone night disposable version—that both take streamed to a user’s in granting the nRF9160 access to its network Completed regulatory certifications the form of a small, wearable finger sensor. smartphone via Bluetooth The device records photoplethysmography LE using a Nordic SoC and (PPG) readings using a 50 Hz optical reflective then processed in the Cloud Cellular IoT (LTE-M and NB-IoT) brings many advantages Countries that have granted regulatory certification for Nordic’s nRF9160 SiP sensor. This shines light onto the finger and using what is claimed to give the over other LPWANs. Key to these advantages is that from the intensity of reflections determines, NightOwl its professional sleep lab cellular operates in licensed bands. By controlling access to among other parameters, the oxygen accuracy: An advanced sensor data algorithm these bands, the owners can guarantee the performance saturation level of the blood (SpO2). developed by Ectosense CTO, Frederik Massie, and reliability of communication and interference between certification, an end-product would be barred from Sudden changes in this blood oxygen level that looks for sleep apnea events. Collected The NightOwl takes the form devices is kept to a minimum. As a result, cellular offers cellular access. Separate certification is needed for are the most accurate indicator of sleep apnea results are displayed on an online dashboard of a small, wearable very high Quality-of-Service (QoS). Tight control of the LTE-M and NB-IoT network access. (Not all operators - a condition where an individual’s breathing available to doctors. finger sensor spectrum also brings unrivaled security. Since its volume have certification schemes.) To maintain such high QoS and security, network production companies operate a highly regulated environment and in July 2019, The nRF9160 down under Smart Agriculture Internet of Things demand that before a wireless device can connect it meets The latest company to grant certification for the Nazek El-Atab various levels of certification. For cellular IoT products Nordic’s nRF9160 SiP is Telstra, Australia’s premier network Water quality with the team’s multisensory system © 2020 KAUST Cross tech IoT info the first level of certification is governed by the Global Certification Forum (GCF) and PTCRB, and once achieved nRF9160 low operator. The certification is for the company’s LTE-M network which covers approximately three million square power SiP has sensor keeps fish exchange now possible demonstrates the product is compatible with the LTE 3GPP specifications for LTE-M and NB-IoT. been moving kilometers of the country. “Telstra is one of the leading technology companies swimming Researchers at Graz University of Technology in Austria have developed a Hurdles to clear rapidly through in the region and is recognized throughout the world,” says Bjørn Åge “Bob” Brandal, Nordic’s Director of Sales the certification & Marketing – APAC. “With LTE-M certification in place system that enables information exchange Additional certification is then required from regional Solar powered Bluetooth LE water quality between commercially available devices bodies to allow the sale of radio equipment into a process we expect to soon follow with certification for Telstra’s sensors developed at the King Abdullah that use different RF protocols but the geographical area. Such testing ensures an RF device NB-IoT network.” University of Science and Technology same frequencies. The generic framework, works properly and does not interfere unduly with “What this certification means for Nordic customers is (KAUST) in Saudi Arabia, could help fish called X-Burst, enables IoT devices using other equipment. There are a host of regional that if they are a Telstra partner, or want to use the Telstra farmers protect their aquatic assets and help different protocols such as Bluetooth regulatory bodies across the globe including FCC (U.S.), network, they can use the nRF9160 SiP with confidence,” safeguard the future of food. LE and Zigbee to communicate with one CE (Europe) and SRRC (China). explains Wendell Boyd, Nordic’s Regional Sales Manager Aquaculture currently supplies more than that each face serves a different purpose.” The another without the need for a gateway. LTE-M and NB-IoT operate within designated bands for ASEAN, Australia and New Zealand. half the world’s seafood and in the last 10 connected chips then act as one device. The researchers make use of time- across the cellular spectrum allocation ranging from B1 to “For projects that require extremely low power, battery years, the profits from global fish farming have The cube is designed to float with the sensors controlled energy pulses in the radio B85. Separate certification is required from the global and operation and a small form factor, the nRF9160 really is quadrupled to more than $230 billion annually. for pH, temperature, salinity and ammonia channel, which can be generated by any regional authorities although only a subset of the bands is the only choice. Nordic customers already have volume However, pollution from industrial activities is levels on the downward facing side. The casing smart device and detected by most of applicable to each region. projects under development using the nRF9160 that seeping into commercial ponds and killing off is weighted to ensure it remains that way, them: “We send data packets of varying Since its volume production in July 2019, Nordic’s nRF9160 we should see operating on the Telstra network millions of dollars’ worth of fish. According to even when disturbed by fish. “We wanted to lengths,” explain Rainer Hofmann and low power SiP with integrated LTE-M/NB-IoT modem and during H2 2020.” Electrical engineer Muhammed Hussain, most create something small and light weight,” says Hannah Brunner, who were in charge of GPS has been moving rapidly through the certification Telstra’s certification follows that of Deutsche Telekom existing commercial sensors only monitor El-Atab. “The farmer can simply throw the the project. “The information is stored in process. At the time of writing the cellular IoT solution— (for its LTE-M network in Germany and NB-IoT networks one thing at a time, such as acidity or oxygen device into the water, and it rotates itself into the duration of the packets. The receivers available in a single version capable of operating in most in Austria, Czech Republic, Germany, Croatia, Netherlands, levels, on individual devices that the farmer the right position.” monitor the energy level ... and can thus of the LTE frequencies used across the globe—has been Tech Check Poland and Slovakia), Verizon (LTE-M network in the must check manually. However, Hussain and The other outer faces include sensors that detect the packets, determine their certified as meeting the LTE 3GPP specifications by GCF The nRF9160 SiP’s U.S.) and Vodafone (NB-IoT networks in Australia, Czech his team have created a small self powered monitor air pollution, solar cells to charge the duration and extract the information.” and PTCRB and no less than 13 regional regulatory bodies integrated modem Republic, Germany, Greece, Hungary, Ireland, Italy, sensor that monitors multiple water quality battery sealed within the cube, and an antenna The invention also enables the system on every continent bar Antarctica. (See map.) supports both LTE-M Malta, New Zealand, Portugal, Spain, South Africa, The and NB-IoT. With 700 characteristics and transmits the data for transmitting data via Bluetooth LE to clocks of the various devices to be Once the global specification and regional compatibility Netherlands, Turkey, U.K. and Ukraine). to 2200 MHz LTE band via Bluetooth LE. a smartphone. synchronized, which allows them, for certification is acquired, there is potentially another In addition to operational certification, the nRF9160 support the product can “Integrating different functions on to one The researchers are now working on example, to perform certain actions hurdle to overcome - that of the network operator. This operate across the globe has also been certified by the Arm Platform Security computer chip is complex and expensive,” improving the device’s self cooling technology simultaneously. X-Burst also allows for certification demonstrates that the network operator is removing the need for Architecture (PSA) scheme and meets PSA Certified explains lead author Nazek El-Atab. “But we to stop it from overheating and the next step intelligent use of frequencies by allowing happy that the cellular IoT solution connects and operates regional variants Level 1. PSA certification aims to improve IoT protection have combined several chips into a cube so will be to test it in the field. all devices to communicate. according to the strict rules for its network. Without this assurances and accelerate IoT device deployment. 6 W Issue 2 2020 Issue 2 2020 W 7
Special Report: COVID-19 Special Report: COVID-19 The why this novel coronavirus has gripped the world is that its initial R value was around 2.5. That is frighteningly high compared to the other coronaviruses and is primarily due Good Fight to four things: First, the virus is highly contagious; second, carriers are infectious without showing any symptoms; third, apart from seniors or those with co-morbidities such as heart disease or diabetes, this coronavirus generally doesn’t kill - allowing the host to spread the disease to people such as healthcare workers who have to come into contact with them; and finally, even in the decade or two since SARS and MERS broke out, international travel has become far more routine - making it easier for the virus to COVID-19 is wreaking havoc on health and the global economy. radiate quickly from its source. But the world is rising to the challenge and arming itself with technology to beat novel coronavirus FIRST LINE OF DEFENSE While viruses are unrelenting in their attack (see sidebar Life, but not as we know it: Anatomy of a virus) the human immune system is well designed to engage in a vicious T battle to repel the invaders. The struggle goes one of two In Short he smart money is on SARS-CoV-2 originating KNOW THE ENEMY ways: The immune system wins and the patient lives (but SARS-CoV-2 is in bats. That’s because the ‘novel’ coronavirus SARS-CoV-2 was first identified in a 55-year-old in Wuhan, the damage to organs can leave the victim with long term believed to have currently terrorizing the world is 96 percent the capital of the central Chinese province of Hubei, in health problems) or the virus does. And victory for the originated in bats genetically identical to another coronavirus that mid-November 2019. Appearing without fanfare, the virus means the end of the host. before chance scientists had already identified in the flying mammals. coronavirus gripped the population of Wuhan with such Survival from an infectious disease sometimes bestows mutations enabled And SARS-CoV-1, the virus which caused and is named for speed that the authorities had little time to react. But when the victim with immunity because the original illness the virus to ultimately the severe acute respiratory syndrome (SARS) outbreak it came time to draw up plans to combat the virus it became ‘primes’ the system against further attack. Should jump to humans in 2002-3, and MERS-CoV, the one that caused the later clear it was similar to the versions that caused SARS and the virus reappear at a later date, the immune system The virus has spread outbreak of Middle East respiratory syndrome (MERS), MERS yet more far more infectious and with subtle twists. recognizes it immediately and launches a powerful assault rapidly because it is were also traced back to bats. SARS and MERS might be harder to catch but they before the virus can replicate in large numbers. Immunity highly infectious, and The next animal to be infected with coronavirus was likely are deadlier, killing a greater percentage of victims. But is not assured though, because even a minor mutation carriers don’t always not a human, but something that lives near bat caves such while outbreaks of the disease were nasty, they were can disguise a largely unchanged virus such that it can slip show symptoms, as a pangolin. (The SARS virus infected humans via civet much easier to contain because victims only became beyond the body’s defenses. rarely die, and traveled cats and MERS did the same via camels. “It’s likely that this infectious when showing symptoms. That meant patients A vaccine is the ultimate man-made weapon in the widely, making it new SARS virus has a similar route,” evolutionary biologist could be shunted hastily into quarantine, limiting contact battle against a virus. For example, Smallpox, a easy for COVID-19 to propagate Dr Jemma Geoghegan of the University of Otago, NZ, told with others. SARS-CoV-2 is much sneakier; victims are disease caused by the variola virus and which Australian broadcaster ABC.) infectious for up to a week before symptoms show, and killed an estimated 300 million people in the 20th The high infection From there, chance mutations that enabled the virus to often sufferers exhibit no outward signs of illness even century, became the first infectious disease to rate and lack of a jump to humans and a potent cocktail of live wild creatures, as the disease runs its course. As many asymptomatic be eradicated, largely by vaccination, in 1980. vaccine has led to domestic animals and humans living cheek-by-jowl carriers jumped on planes and flew to destinations across But a vaccine can take years to develop and the rapid adoption of technology to help triggered coronavirus disease 2019 (COVID-19). According the planet, they unknowingly became perfect vectors test, so is far from a quick fix. Or even a fix at all; fight further spread of to U.S. magazine National Geographic, a wet market in for COVID-19, sowing the seeds of major outbreaks in despite considerable research, there is still no the virus Wuhan, China, is believed to be the original epicenter of Iran, Italy, Germany, the U.K. and the U.S. and dozens of vaccine for SARS-CoV-1 or MERS-CoV or indeed COVID-19. This wet market had a wild animal section where other countries besides. any other coronavirus. Wearables, wireless pulse oximeters, live snakes, beavers, porcupines and baby crocodiles were Every cough, sneeze or touch from a carrier spreads If enough people gain immunity—whether through Bluetooth LE-powered for sale. And, according to The Economist magazine, while hundreds of millions of viruses far and wide. For example, surviving the full-blown disease or vaccination—the handwashing and hand officially off limits because they are an endangered species, recent research, published in the Journal of the American virus fails to find enough hosts and the outbreaks stops sanitization solutions pangolins have also been known to make it from wet Medical Association and originating from a study by MIT in its tracks. The effect is known as ‘herd immunity’ and have all been rapidly markets to Chinese menus. associate professor Lydia Bourouiba, warned that virus- requires perhaps 60 to 90 percent of the population to be deployed by tech While SARS and MERS quickly ran their course and deaths laden droplets from a sneeze can travel up to eight meters exposed to the disease to be effective. companies were limited to under a thousand in each case, today’s and remain suspended in the air for up to ten minutes. Some governments were keen to establish herd coronavirus has become a pandemic, with fatalities running Other research shows the pathogen can live in droplets immunity by letting coronavirus rip through the population. to hundreds of thousands. that land on hard surfaces certainly for hours and perhaps But they soon changed tack when it was realized that This is a challenge the like of which hasn’t been seen even days. A person who breathes in the suspended while most victims might not die, many would get very before by virtually anyone alive today. But when backed droplets will become infected, and others that get droplets sick and need hospital treatment—often expensive into a corner, the world rises to the task. Now a global on their hands from the surfaces on which they land will and comparatively rare intensive care—overwhelming cohort of scientists, engineers and medical professionals transfer it to eyes, nose or mouth by touching their face – healthcare services and exposing medical staff to the brunt are pooling their skills and resources to fight back against something we all do about 15 to 20 times an hour. of the viral attack. And second, a lot of vulnerable people SARS-CoV-2. And wireless connectivity is proving to be The infection rate of SARS-CoV-2 (called R or R0) would succumb quickly. “Eventually, we [will] achieve one of the most useful weapons enabling them to fight determines how rapidly things develop by quantifying herd immunity, but we don’t want that to happen quickly,” this global threat in a way that’s never been done before. how many people each virus carrier will infect. The reason Gypsyamber D’Souza, a professor of epidemiology at 8 W Issue 2 2020 Issue 2 2020 W 9
Special Report: COVID-19 Special Report: COVID-19 is a key early symptom of COVID-19, the country combined CCTV, facial recognition and temperature-sensing robots to feed machine-learning programs that then identified Life, but not as we know it: Anatomy of a virus potential victims early. Taiwan used an existing household registration system, cell phone data, a national health Viruses have been on this planet for 1.5 billion years. spikes act as ‘keys’ locking onto to the host’s cell and insurance database and immigration records to build an According to 2015 research published in Science opening a door in the cell membrane. Particular spikes AI algorithm that tracked individuals based on their travel Advances, cellular life came first with bacteria and only unlock particular cells which is why viruses can and medical history. This identified vulnerable individuals then multicellular forms taking that basic unit of thrive only inside a ‘compatible’ host. Inside the cell the and made it much easier to inform people who had been in life and becoming more complex. Viruses took the virus does the one and only thing it has evolved to do – contact with a potentially infected person so they could opposite path, getting rid of all but the most essential replicate. It does this by hijacking the cell’s machinery then volunteer for testing. genes in an evolutionary track toward simplicity to make copies of itself – millions of copies. Eventually In the U.S. connected health specialist, Kinsa Health, for (although recent French research has unearthed a the cell succumbs to the workload and dies. Meanwhile example, used data from millions of Nordic Semiconductor virus with 1000 genes, not far short of that found in the newly-hatched viruses flood into the bloodstream Bluetooth LE smart thermometers to gather anonymized a bacteria). Some even suggest they represent the to repeat the process by hijacking cells elsewhere. data then forwarded this information from smartphone pinnacle of evolution – fine-tuned to perfection. Because viruses contain only a few genes (the long as five decades of mutations to occur. apps to build a patient-temperature ‘heat map’ of But perhaps not quite, because viruses are not alive influenza virus, for example, comprises 14 active Only comparatively few viruses are deadly to the country that could be used to quickly identify in the sense a cell is because they lack the fundamental genes) random mutations can have a significant effect. humans and even fewer run riot. But when they do it potential COVID-19 hotspots and help agencies precisely machinery—such as a nucleus, organelles and And genes can even be swapped between viruses. can get very bad. The last pandemic was caused by target scarce resources. (See Case Study pg12.) mitochondria—that humans define as being necessary This could mean, for example, that a coronavirus from ‘Spanish Flu’, and it killed up to 100 million people in The main method of lowering the infection rate and for life. And they now have so few genes that they a bat infecting a pangolin swaps genetic material 1918-19. But that was caused by an influenza virus bringing an outbreak under control is to keep people apart can’t reproduce (or ‘replicate’ as virologists prefer) on with another virus in the animal’s cells resulting in a rather than a coronavirus. The latter has proved Johns Hopkins University told Time magazine. “There would so that the virus runs out of hosts. Governments around their own. Unfortunately, that’s where the problems new coronavirus with protein spikes that can open relatively benign and we have lived alongside be so many deaths.” Perhaps as many as 35,000 for every the world have implemented strict ‘lockdown’ regimes and start for multicellular creatures like mammals. up human cells. That’s not something that happens coronaviruses for thousands of years with no harm million infected. That is too high a price to bear. Technology then social distancing for the occasions when people do Streamlined virus architecture comprises little overnight; according to The Economist magazine, the done beyond a few sniffles due to the four types that have to leave the safety of their homes. But even when more than DNA (or its precursor, RNA), a protein shell, four percent genetic difference between the related cause 25 percent of common colds. Coronaviruses TECHNOLOGY FIGHTS BACK is needed to everyone tries hard to abide by the rules, slip ups happen, an outer envelope and protein spikes. Once the virus coronavirus identified in bats and that currently have never before been responsible for a pandemic. Considering the high infection rate, lack of a vaccine enforce social and people pass close enough for the virus to take its gets inside a host such as a mammal, the protein infecting humans took at least 20 years and maybe as That’s why SARS-CoV-2 has caught us napping. and the political untenability of gaining herd immunity distancing. chance. Bluetooth LE is at the heart of one technology by natural means, SARS-CoV-2 presents a challenging being used to advise people if they’ve been unfortunate opponent. That has encouraged the use of technology to Bluetooth LE enough to pass close to someone who’s later tested bring the virus to heel. wearables positive for COVID-19 so they can arrange for their own In Australia, for example, after a big publicity campaign only By the Numbers 76 Testing for the virus is critical to managing the infection are emerging test. The system is based on a cooperation between tech- four million people had downloaded the contact tracing app rate because so many carriers are asymptomatic. If giants Apple and Google and uses a Bluetooth LE service several weeks after its launch. The Australian government apparently well people know that have the disease, they as one of the together with an app for detecting smartphone proximity. said at least ten million (40 percent of the population) need can stay away from others until it runs its course (typically most promising Such technology is valuable but does have a drawback: to download the app for contact tracing to work. 14 days). But it is impossible to rapidly check the whole While the virus doesn’t discriminate, the technology Companies are aware of the privacy concerns and have population—even a country with the resources of the U.S. workplace requires the services of an expensive smartphone, which is issued statements to reassure the public. Apple and SARS-CoV-2 took several months to test just 10 million people out of a solutions beyond much of the world’s population. An alternative that Google say “user privacy and security [are] central to the vaccines under population of 328 million—so testing has to be targeted still takes advantage of proximity measurement through design” of their technology and Accent Systems CEO, Jordi development at high-risk individuals. Bluetooth LE, but costs a lot less than a smartphone, is a Casamada noted: “Only authorized authorities can access 14 Early efforts in China used machine learning, a form of AI, wearable. One example has been developed by Spanish the [wristband] data, and only when required. Otherwise to zero in on those who should be tested. Because a fever engineering company, Accent Systems; the Covid-19 BLE the whole system is completely anonymous and collected wristband is uniquely identifiable and uses Bluetooth LE data [is] automatically deleted after 15 to 30 days.” (See to detect and record the user ID of every other wristband pg16 for more about contact tracing privacy issues.) that it comes near over a 30-day period. If a wearer later SARS-CoV-2 State of Play develops COVID-19 symptoms, their data is automatically LIFE ON THE FRONT LINE antiviral Unholy trinity: Killer coronaviruses downloaded at a medical center so everyone they have Suffering from COVID-19 is no fun for anyone, but for come into contact with can be advised. some the suffering is easier to bear. SARS-CoV-2 seems drugs under Researchers have identified hundreds of coronaviruses—so-called because One challenge with contact tracing devices is that some to hit the elderly the hardest followed by those of any development under the microscope the pathogens look like they’re wearing crowns—since perceive them to be an infringement on civil liberties. age who are unfortunate enough to suffer from co- Source: WHO they were first identified in chickens in the 1930s. Seven infect humans of which This perhaps explains the reticence of many to use morbidities. Meanwhile, younger, healthy people seem According to National Geographic magazine, one nasty four cause little more than the common cold. The other three are deadly, with the government-mandated smartphone contact tracing apps. only to be troubled by little more than a raised temperature. aspect of SARS-CoV-2 is that it while it causes the one causing MERS the worst, but SARS-CoV-2 is by far the most contagious. But it’s not always true that mild symptoms at the oxygen saturation of the blood to dive, patients don’t feel beginning of the illness will signal the same throughout. breathless. That’s different to other respiratory diseases. British Prime Minister Boris Johnson, for example, a healthy As an example, the magazine reported that one COVID-19 Coronavirus Outbreak Countries infected Infections Deaths Fatality rate 55-year-old, contracted COVID-19 and spent ten days at patient in Oslo, Norway was talking and smiling, but his blue SARS-CoV-1 2002-3 29 8,100 774 9.5% home with few problems, before his condition deteriorated lips told another story, an oxygen saturation of 66 percent MERS-CoV 2013-20 27 2,519 866 34.3% rapidly, and he was admitted to a hospital intensive care (compared with a normal level of 96 percent or greater) a unit requiring specialist treatment including oxygen. And level that causes major organ damage. SARS-CoV-2 2019-mid 20 216 7.3 million 415,000 3.4% (est.) what happened to Johnson has affected others. This gradual worsening of COVID-19 can get missed Source: CDC, WHO, The Lancet 10 W Issue 2 2020 Issue 2 2020 W 11
Special Report: COVID-19 Special Report: COVID-19 until a sudden collapse which then requires expensive and while handling patients must be immediately discarded could see even the world’s sixth largest economy in trouble restricted hospital care. If the decline could be picked up after the examination to avoid cross-contaminating unless restrictions are eased. And the U.K. is far from alone. earlier, less intensive therapy could be sufficient to arrest anyone else. While industry has responded to shortages by In the absence of a vaccine but with restrictions eased, the disease and take pressure off hospital resources. repurposing machines to manufacture desperately needed technology will become even more important. “Even Pulse oximeters are one solution. These devices monitor PPE (see sidebar Retooling: From monocoques to masks), as lockdowns are eased and workers return, COVID-19 the blood oxygen level such that the tell-tale signs of there is still pressure on stocks. Nordic customer Cleanbox will remain a risk factor for some time,” explains Geir COVID-19 getting on top of a patient are indicated early. The Masimo Radius PPG Technology has taken repurposing a step further to save Langeland, Nordic’s Director of Sales & Marketing. Nordic customer Masimo’s Radius PPG pulse oximeter is pulse oximeter wirelessly precious supplies. The company has adapted its VR headset “Technology is needed to enforce social distancing reports blood oxygen a wireless device renowned for its accuracy, and, according levels to a Cloud server cleaner to sterilize worn masks so they can be reused. As even when workers are distracted, along with rapid to the company, is the preferred choice in nine out of the part of the process the company’s CX1 system employs UV contact tracing should someone contract the virus. top ten hospitals in the U.S. The pulse oximeter is wirelessly light and super-hydrophobic nanotech coatings that repel Bluetooth LE wearables are emerging as one of the connected to a patient’s smartphone which reports blood fluids and prevent them from seeping into masks, as well most promising workplace solutions.” oxygen levels to a Cloud server. In this way medical staff as an air system that removes detritus and any wetness Nordic customer Estimote has introduced a range Sani nudge uses staff- can manage large numbers of patients remotely. remaining at the surface of the mask. The 60-second worn Bluetooth LE tags of workplace safety contract tracing wearables. The “We didn’t originally develop Radius PPG to combat cleaning and drying cycle eliminates bacteria, viruses and and sensors attached to healthcare company. “Now in the eye of the hurricane hand wearables are worn by everyone within a specific work COVID-19,” says Bilal Muhsin, Chief Operating Officer of fungi. Nordic Bluetooth LE connectivity makes it easy for hand sanitizer dispensers hygiene compliance is at the top of the quality list.” location, and if one worker is unfortunate enough to to track hand hygiene Masimo. “But it turns out that in the current crisis this technicians to configure the machine for extended cleaning compliance The company has developed Bluetooth LE sensors which develop COVID-19, this data can be used to identify which wireless capability, when paired with a secure, cycles or longer air bursts, for example. are attached to sanitizer dispensers to detect when staff employees may have been exposed to the virus and— Cloud-based telehealth platform … can provide a Cleanbox Technology “[The machine enables] continuous cleaning throughout use them. In addition, staff wear a tag which determines crucially—the exposure time and thus the risk of infection. valuable way to manage COVID-19 patients who do has re-engineered its the day … without the use of chemicals,” explains Amy how often they use a sanitizer or other handwashing While contact tracing wearables for public use trigger not require hospitalization.” VR headset cleaner Hedrick, CEO of Cleanbox Technology. facilities. Sensors are also fitted above patient beds so notification but can’t determine positional information, an to sterilize multiple Home monitoring with pulse oximeters and smart medical masks for reuse Discarding PPE to avoid cross-contamination means that staff contact with them can be precisely monitored. A employer using the Estimote system can add reference- thermometers relieves pressure on health services, there are times when medical staff are without gloves. It smartphone app summarizes the data so users can quickly location Bluetooth beacons around the premises to allowing them to focus on the thousands who are only takes the droplets from a patient’s sneeze to alight on see if their hygiene regime is satisfactory. determine where the infected person had been working hospitalized, but that means doctors, nurses and support a door handle, a light switch or a pen and the virus ends up and target that area for extra cleaning. staff must put their own safety at risk to help the sick. on medical staff’s hands, just a touch of the face away from LEAVING THE TRENCHES PHYTEC, a German technology company is generating Social distancing is not an option when tending a patient infection. The solution is systematic handwashing - soap or The problem with lockdowns is that while they help ‘flatten positional information in a different way by combining and faith is put in personal protection equipment (PPE) the alcohol in hand sanitizer breaks down the protein coat the curve’ of outbreaks they put people out of work and Nordic Bluetooth LE with ultra wideband (UWB), a short such as gloves, masks, gowns and goggles. of the virus, rendering it harmless. pull the rug from under economies. During the course of range wireless technology. Bluetooth LE is used to The supply of PPE has been compromised by high Doctors and nurses can be so busy coping with the PHYTEC’s social the pandemic, the U.S.’s unemployment rate is set to peak determine proximity while UWB determines exactly how demand, not just from hospitals but also from the public number of patients that handwashing can be forgotten. distancing tracker at a staggering 25 percent. Elsewhere, the U.K.’s economic close people have approached. keen to protect themselves. Yet medical staff need PPE “Before COVID-19 … healthcare workers saw [hand enables face-to- output has contracted by a crippling 35 percent so far; Such precision allows an alarm to sound if a person moves face separation more than others because when treating victims, the virus hygiene] more as a task that ‘just had to be done’,” says Dr. measurements within added to the costs of supporting workers and tax cuts into the 1.5 meter danger zone where the risk of infection is ever-present. The gloves and masks offering protection Marco Bo Hansen, Medical Director of Sani nudge, a Danish 5-10 cm accuracy for business to help them stay afloat, such a contraction dramatically escalates. Precise distance information is also Case Study: A high fever is considered Low power processing The nRF52810 has the lowest Smart thermometers detect virus symptoms one of the key symptoms of Both the QuickCare and Smart Ear devices are battery powered. power consumption in Nordic’s proven nRF52 Series yet COVID-19 so being able to track early to identify COVID-19 clusters this health data is an extremely Because replacing batteries frequently on the front line is not retains the 64 MHz, 32-bit Arm Cortex M4 processor for the an option, Kinsa Health required an performance demands of secure N ow more than ever, early detection of the Two such devices are smart thermometers. measuring human body temperature, but also powerful way to quickly identify ultra low power Bluetooth LE solution Bluetooth LE connectivity and symptoms of contagious illness is vital The first is the low cost Kinsa QuickCare oral providing anonymized data through the Kinsa any new outbreaks” that also provided sufficient onboard fast data processing. to protect individual patients and entire thermometer that can provide a temperature App to produce a temperature heat map of the processing power and memory allocation Moreover, Nordic’s SoftDevice communities. An early response to confirmed reading in around eight seconds and the other U.S. known as the ‘U.S. HealthWeather map’. By to essentially run the complete smart (RF protocol ‘stack’) provided a major symptoms is equally important. For example, is the Kinsa Smart Ear aural thermometer that following this map, government agencies and help predict and curb the spread of medical applications from a single chip. advantage for Kinsa Health throughout being able to rapidly and accurately identify can supply a temperature reading in as little as healthcare organizations are able to identify disease outbreaks.” Nordic’s nRF52810 SoC fit the bill. the development process. “The clusters of people with high temperatures—and a second. Both devices connect via Bluetooth potential virus hotspots immediately. According to the company, these solutions The reliability of the Bluetooth LE SoftDevice is unquestionably one of the thus potential COVID-19 outbreaks—could help LE to the Kinsa App, which keeps a log of “On the back end we anonymize and are capable of making a difference in a crisis connectivity and the ultra low power most compelling reasons to use Nordic,” combat the spread of coronavirus. Thanks to readings and serves as a ‘nurse in the pocket’ aggregate temperature and symptom inputs such as COVID-19. “A high fever is considered consumption, particularly in sleep mode, says Gal. “It lets us focus on application U.S. connected health specialist, Kinsa Health, by providing users with information including to [generate] an illness signal, which tells us one of the key symptoms of COVID-19 so allow the Kinsa smart thermometers to development knowing that we have a this is now possible. guidance on the illness severity and when to what percentage of a population is ill in any being able to track this health data is an transmit data relatively infrequently and robust and well implemented Bluetooth LE For a number of years, Kinsa Health has seek further medical advice. given U.S. geography be that county, state or extremely powerful way to quickly identify extend battery life. solution we can rely on.” been dedicated to developing affordable yet In the midst of the current pandemic or region,” says David Gal, Kinsa Health CTO and any new outbreaks,” says Gal. “If testing and “For the most part our devices live in a Given Kinsa Health made nine in ten of highly effective wireless medical devices at any time in the future, Kinsa Health’s VP of Engineering. “Additionally, using machine containment resources can then be focused medicine cabinet, but when a user pulls out the smart thermometers sold in the U.S. in to track and curb the spread of infectious network of millions of Bluetooth LE-enabled learning and AI, we [extrapolate] these illness on these areas the spread of the virus could be the device in the middle of flu season, the the 12 months up to March 2020, it seems diseases, including influenza-like illnesses. smart thermometers are capable of not only signals. We use these signals and forecasts to significantly slowed down and lives saved.” product needs to work,” says Gal. most consumers agree. 12 W Issue 2 2020 Issue 2 2020 W 13
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