Taking stock: An assessment of 2020 for the EU5 pharma market, and the lessons for 2021 - Iqvia
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Taking stock: An assessment of 2020 for the EU5 pharma market, and the lessons for 2021 Sarah Rickwood & Natalie Harb Webinar: September 29, 2020 © 2020. All rights reserved. IQVIA® is a registered trademark of IQVIA Inc. in the United States, the European Union, and various other countries.
IQVIA speakers for today’s session Sarah Rickwood, Natalie Harb Vice President, Senior Principal, European Marketing and Thought Leadership Global Analytics Solutions © 2020. All rights reserved. IQVIA® is a registered trademark of IQVIA Inc. in the United States, the European Union, and various other countries. 1
Agenda 1 Taking stock: An assessment of 2020 for the EU5 pharma market 2 Latest Sales Trends & HCP engagement across the EU5 Countries 3 Lessons for 2021 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 2
Where is the world in the COVID-19 pandemic? Over 40% of the global population lives in countries past the initial peak Not yet peaked Peaked but not yet at < Less than Experiencing second wave 20% of peak 20% of peak or signs of a rebound Countries: 34 Countries: 51 Population: Countries: 52 Countries: 42 Population: 2.3bn 2.0bn. Population: 2.5bn Population: 0.8bn • Most South American • Joint most African • Most Central • Joint most African • Most European and Oceania countries countries countries American, Eastern countries • Canada, Australia, UK, Japan • India, Syria, Peru European, and • Most Asian and Middle Eastern Caribbean countries countries • Italy, Portugal, Thailand • US, Brazil, Iran, Mexico 30% 27% 33% 10% population population population population Source: IQVIA European Thought Leadership estimations based on World Bank population data, John Hopkins University ("Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Inf Dis. 20(5):533-534. doi: 10.1016/S1473-3099(20)30120-1“) COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 3
COVID-19 has induced a significant fluctuation in pharma sales across the globe with varying impact across drug classes Global Pharma Sales in Standard Units – Retail + Hospital market Global Pharma sales (Bn SU/day) Global MoM growth baselined vs. Change in YTD sales 2019 vs. 2020 (%) average MoM growth 2015-2020 -1.3% 6.5 1,054 6.0 5.5 1,040 5.0 0.0 Jan-15 Jan-16 Jan-17 Jan-18 Jan-19 Jan-20 Jun-20 Jul-15 Jul-16 Jul-17 Jul-18 Jul-19 Jul-20 Jan-15 Jan-16 Jan-17 Jan-18 Jan-19 Jan-20 2019 2020 • Increased use of generic medicines during the COVID-19 • Biologic medicines and branded drug sales have seen pandemic could reflect a shift in healthcare priorities reduced use during the COVID-19 pandemic • COVID-19 occurred in the same period as a shift towards • Impact of COVID-19 is most pronounced in primary care biosimilars but it may be a coincidence medicine usage Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 4
In terms of overall pharma sales, both the US and EU5 have experienced similar peaks mid-pandemic Pharma Sales in Standard Units – Retail + Hospital market US Pharma sales (Mn SU/day) EU5 Pharma sales (Mn SU/day) 1,000 1,000 800 800 600 600 400 400 200 200 0 0 Jan-19 Mar-19 May-19 Jul-19 Sep-19 Nov-19 Jan-20 Mar-20 May-20 Jul-20 Jan-19 Mar-19 May-19 Jul-19 Sep-19 Nov-19 Jan-20 Mar-20 May-20 Jul-20 US quarterly peak magnitude baselined vs. Avg 2015-2020 EU5 MoM baselined vs. Avg MoM 2015-2020 Jan- Jan- Jan- Jan- Jan- Jan- Q1 Q1 Q1 Q1 Q1 Q1 15 16 17 18 19 20 2015 2016 2017 2018 2019 2020 Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 5
There was a proportional increase in specialty and small molecule spend which was highest in the UK Absolute difference (Jan-Jun 2020 v/s Jan-Jun 2019) in LCEuros Mn Specialty Traditional Biologics Small Molecules €650Mn -€98Mn €487Mn €65Mn €1,170Mn €376Mn €903Mn €644Mn €90Mn -€219Mn €136Mn -€265Mn €451Mn €109Mn €249Mn €310Mn €758Mn €110Mn €339Mn €529Mn France Germany Italy Spain UK Period on Period growth % LCEuro Period on Period growth % LCEuro (Jan-Jun 2020 v/s Jan-Jun 2019) (Jan-Jun 2020 v/s Jan-Jun 2019) FRA GER ITA SPA UK FRA GER ITA SPA UK Max. growth Specialty 9% 11% 1% 9% 14% Biologics 10% 11% 3% 8% 10% Min. Growth Traditional -1% 4% -3% 2% 2% Small Mol. 1% 6% -3% 4% 7% Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 6
Hospital and retail have shown different responses to COVID crisis; hospital value growth despite volume falls Hospital Retail Value: Difference in YTD sales 2020-2019 (Mn LCEuro Jan-Jun, Abs) Value: Difference in YTD sales 2020-2019 (Mn LCEuro Jan-Jun, Abs) 679 1,389 443 368 158 184 116 189 49 -178 France Germany Italy Spain UK France Germany Italy Spain UK Volume: Difference in YTD sales 2020-2019 (Mn SU Jan-Jun, Abs) Volume: Difference in YTD sales 2020-2019 (Mn SU Jan-Jun, Abs) 853 209 -157 -142 -168 -193 -22 -203 -279 -407 France Germany Italy Spain UK France Germany Italy Spain UK Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 7
Preliminary data shows recovery across Hospital and Retail in June Hospital Retail Value: EU5 Hospital 2020 vs. same period 2019 (LCEuro %) Value: EU5 Retail 2020 vs. same period 2019 (LCEuro %) 30 30 20 20 10 10 0 0 -10 -10 -20 -20 -30 Jan Feb Mar Apr May Jun Jan Feb Mar Apr May Jun Volume: EU5 Hospital 2020 vs. same period 2019 (Standard Units %) Volume: EU5 Retail 2020 vs. same period 2019 (Standard Units %) 20 30 0 20 10 -20 0 -40 -10 -60 -20 Jan Feb Mar Apr May Jun Jan Feb Mar Apr May Jun Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 France Germany Italy Spain UK COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 8
The UK leads the EU5 in proportional value increase and volume decrease during the pandemic Hospital Retail Value: Difference in YTD sales 2020-2019 (LCEuro Jan-Jun, %) Value: Difference in YTD sales 2020-2019 (LCEuro Jan-Jun, %) 11.3% 8.3% 7.9% 4.2% 6.9% 5.3% 2.1% 2.4% 0.5% -3.9% France Germany Italy Spain UK France Germany Italy Spain UK Volume: Difference in YTD sales 2020-2019 (SU Jan-Jun, %) Volume: Difference in YTD sales 2020-2019 (SU Jan-Jun, %) 3.0% -5.2% 0.7% -8.9% -0.1% -11.0% -13.1% -1.0% -14.7% -1.7% France Germany Italy Spain UK France Germany Italy Spain UK Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 9
For most primary care pattern across countries is similar; more divergence in specialty Value: EU5 Oncology 2020 vs. same period Value: EU5 Immunology 2020 vs. same period Value: EU5 Anticoagulants 2020 vs. same 2019 (LCEuro %) 2019 (LCEuro %) period 2019 (LCEuro %) 40 40 40 30 30 30 20 20 20 10 10 10 0 0 -10 -10 0 -20 -20 -10 Jan Feb Mar Apr May Jun Jan Feb Mar Apr May Jun Jan Feb Mar Apr May Jun Value: EU5 Antidiabetics 2020 vs. same period Value: EU5 Pain 2020 vs. same period 2019 2019 (LCEuro %) (LCEuro %) 40 30 30 20 20 10 10 0 0 -10 -10 -20 -20 -30 Jan Feb Mar Apr May Jun Jan Feb Mar Apr May Jun France Germany Italy Spain UK Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 10
Looking specifically at the anti-coagulant market – in the US, NOACs grew significantly vs. warfarin while in the EU5 both categories grew strongly NOAC (Novel Oral Anti-Coagulants) and Warfarin Sales in Standard Units – Retail + Hospital market US NOAC quarterly difference EU5 MoM NOAC growth • US use of NOACs has increased baselined 2015-2020 baselined 2015-2020 during the COVID-19 pandemic, likely due to demand for self-administered anti-coagulants • EU5 anti-coagulant use has not been impacted by COVID-19 in a way which favours self-administration US Warfarin quarterly difference baselined EU5 MoM Warfarin growth baselined 2015-2020 2015-2020 • Both NOACs and warfarin growth peaked in March 2020 Warfarin requires regular blood monitoring unlike NOACs, leading to varying preference towards NOACs during COVID-19 period across countries Sep-15 Dec-15 Sep-16 Dec-16 Sep-17 Dec-17 Sep-18 Dec-18 Sep-19 Dec-19 Sep-15 Dec-15 Sep-16 Dec-16 Sep-17 Dec-17 Sep-18 Dec-18 Sep-19 Dec-19 Jun-15 Jun-16 Jun-17 Jun-18 Jun-19 Jun-20 Jun-15 Jun-16 Jun-17 Jun-18 Jun-19 Jun-20 Mar-15 Mar-16 Mar-17 Mar-18 Mar-19 Mar-20 Mar-15 Mar-16 Mar-17 Mar-18 Mar-19 Mar-20 Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 11
While within the EU5, local country policies appear to have created a varying impact on anti-coagulant use during the pandemic NOAC (Novel Oral Anti-Coagulants) and Warfarin Sales in Standard Units – Retail + Hospital market Anti-coagulant usage in Italy Anti-coagulant usage in Germany Anti-coagulant usage in Spain (Mn SU/day) (Mn SU/day) (Mn SU/day) 1.5 4.5 0.8 4.0 0.6 1.0 3.5 3.0 0.4 0.5 2.5 0.2 0.0 0.0 0.0 Mar-18 Sep-18 Mar-19 Sep-19 Mar-20 Mar-18 Sep-18 Mar-19 Sep-19 Mar-20 Mar-18 Sep-18 Mar-19 Sep-19 Mar-20 Nov-18 Nov-19 Nov-18 Nov-19 Nov-18 Nov-19 May-18 Jul-18 May-19 Jul-19 May-20 Jul-20 May-18 Jul-18 May-19 Jul-19 May-20 Jul-20 May-18 Jul-18 May-19 Jul-19 May-20 Jul-20 Jan-18 Jan-19 Jan-20 Jan-18 Jan-19 Jan-20 Jan-18 Jan-19 Jan-20 Anti-coagulant usage in France Anti-coagulant usage in UK (Mn SU/day) (Mn SU/day) 2.5 2.0 2.0 1.5 1.5 1.0 0.5 0.5 0.0 0.0 Mar-18 Mar-19 Mar-20 Mar-18 Mar-19 Mar-20 Sep-18 Nov-18 Sep-19 Nov-19 Sep-18 Nov-18 Sep-19 Nov-19 Jul-18 Jul-19 Jul-20 Jul-18 Jul-19 Jul-20 Jan-18 May-18 Jan-19 May-19 Jan-20 May-20 Jan-18 May-18 Jan-19 May-19 Jan-20 May-20 NOAC Warfarin Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 12
IQVIA’s MIDAS data has tracked very different New Active Substance launch activity across major countries in 2020 Lockdown* announced – 21/Mar Lockdown* announced – 20/Mar Lockdown* announced – 14/Mar 50 US 50 Germany 50 Spain 45 40 40 33 40 32 30 30 30 22 20 20 13 20 15 Number of NAS launches 16 10 10 10 9 12 0 0 0 May May May Nov Nov Nov Feb Feb Feb Aug Sep Aug Sep Aug Sep Jul Jul Jul Jan Mar Jun Oct Jan Mar Jun Oct Jan Mar Jun Oct Apr Dec Apr Dec Apr Dec 2015-19 avg 2020 2015-19 avg 2020 2015-19 avg 2020 Lockdown* announced – 16/Mar Lockdown* announced – 21/Feb Lockdown* announced – 23/Mar 50 France 50 Italy 50 UK 40 40 40 32 30 30 30 27 32 15 18 20 20 20 14 10 14 10 14 10 6 0 0 0 May May May Nov Nov Nov Feb Aug Sep Feb Aug Sep Feb Aug Sep Jul Jul Jul Jan Mar Jun Jan Mar Oct Jan Mar Jun Oct Jun Oct Dec Dec Dec Apr Apr Apr 2015-19 avg 2020 2015-19 avg 2020 2015-19 avg 2020 Source: MIDAS monthly May 2020, secondary research; Note: *California first state in the US to announce lockdown, Bavaria and Saarland are the first two states in Germany to impose lockdowns, at least ten towns in the Lombardy and Veneto regions of Italy were first to announce lockdown COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 13
Agenda 1 Taking stock: An assessment of 2020 for the EU5 pharma market 2 Latest Sales Trends & HCP engagement across the EU5 Countries 3 Lessons for 2021 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 14
Unfortunately it seems like the second wave of COVID-19 is emerging across Europe Number of Reported COVID-19 Infections in EU5 Total confirmed COVID-19 cases 7-day moving total of new COVID-19 cases 700 80 600 60 500 400 Thousands Thousands 40 300 200 20 100 0 0 15-Sep 11-Aug 18-Aug 25-Aug 2-Jun 9-Jun 7-Jul 5-May 3-Mar 14-Apr 21-Apr 28-Apr 8-Sep 25-Feb 7-Apr 16-Jun 23-Jun 30-Jun 14-Jul 21-Jul 28-Jul 4-Aug 1-Sep 12-May 19-May 26-May 10-Mar 17-Mar 24-Mar 31-Mar 7-Jul 2-Jun 9-Jun 3-Mar 5-May 11-Aug 18-Aug 25-Aug 15-Sep 7-Apr 14-Apr 21-Apr 28-Apr 4-Aug 1-Sep 8-Sep 25-Feb 16-Jun 23-Jun 30-Jun 14-Jul 21-Jul 28-Jul 31-Mar 10-Mar 17-Mar 24-Mar 12-May 19-May 26-May Italy Germany Spain France UK Italy Germany Spain France UK ^CFR (Case Fatality Rate) is the ratio of the number of COVID-19 reported deaths to the total number of reported confirmed cases. However, this largely varies with the diagnosis rate and the testing performed by each country; *As of 25th August, **As of 27th August, Data last 30 days; Sources provided in Appendix section COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 15
The younger age cohort are getting infected now during the 2nd wave compared to the older population at the start of the pandemic COVID-19 reported infections in Italy COVID-19 reported infections in Germany Split by age Split by age Till 15th June 24th Aug – 6th Sept Till 16th June 7th Sept - 13th Sept 2% 7% 13% 7% 6% 19% 19% 29% 21% 18% 38% 43% 31% 31% 60% 57% 0-18 years 19-50 years 51-70 years >70 years 0-19 years 20-49 years 50-69 years >=70 years COVID-19 reported infections in Spain COVID-19 reported infections in France Split by age Split by age Till 14th May 31st Aug - 6th Sept As of 16th June As of 15th Sept 1% 0.4% 1% 11% 13% 25% 30% 30% 37% 22% 47% 53% 21% 54% 23% 32% 0-14 years 15-49 years 50-69 years >=70 years 0-14 years 15-64 years 65-74 years >75 years Sources provided in Appendix section COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 16
EU5 Summary Data Facts COVID-19 Reported Numbers* EU5 Total YTD sales and market overview (v. PY) +4.9% • Rx Market: Antineoplastic and Immunomodulating Highest volume growth in Total Cases 1,944,759 agents (ATC L class) and Cardiovascular system (ATC ATC L class in Germany C Class) show an increase in volume sales in most New Cases 23,357 countries • Hospital Market: Antineoplastic and +10.6% Deaths 147,506 Highest volume growth in Immunomodulating agents (ATC L class) show an ATC L class in Spain *As of 15th September increase in volume sales in most countries YTD Volume Growth by Country • CH Market: Patient Care and Personal Care products show positive YTD volume growth rate in most countries +15.6% Increase in volume of with the highest growth reported in Italy for Patient Care Patient Care category in Rx and in France for Personal Care Italy market growth -4.3% -3.9% -3.5% -1.9% +0.2% w37 w37 w37 w37 w37 +233% Hosp. HCP engagement Increase (v. PY) in remote market interactions in Spain. The growth • The UK is the only county that has experienced an corresponding increase in -13.0% -12.2%-11.2% -5.9% -3.4% increase in promotional contact this Sep vs. Italy (v. PY) is +160% M7 M7 M7 M7 M7 CH Sept 2020 market • Face to face interactions shows a decrease in Italy, growth Germany and Spain week-on-week -5.1% -0.3% +0.5% +1.6% +2.3% w37 w37 w37 w37 w37 ATC: Anatomical Therapeutic Chemical Classification; CH: Consumer Health; v. PY: versus Previous Year, M7: July 2020, w37: Week starting 7th September *Source: Center for System Science and Engineering (CSSE) at John Hopkins University (JHU) COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 17
France and Italy saw a spike at the start of August within the Retail market. Within the Consumer Health market, UK saw a sharp decline at the end of August % Growth in Units – Rx retail market, Hospital market, Consumer Health market Retail Rx market Hospital market Consumer Health market % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same week 2019 in EU5 week 2019 EU5 week 2019 EU5 60% 40% 120% 50% 100% 30% 40% % Growth – Units % Growth – Units % Growth – Units 80% 30% 20% 20% 60% 10% 10% 40% 0% 0% 20% -10% -10% 0% -20% -30% -20% -20% -40% -30% -40% W11: 09-Mar W13: 23-Mar W37: 7-Sep W19: 04-May W21: 18-May W7: 10-Feb W9: 24-Feb W15: 06-Apr W17: 20-Apr W29: 13-Jul W31: 27-Jul W23: 01-Jun W25: 15-Jun W27: 29-Jun W33: 10-Aug W35: 24-Aug W3: 13-Jan W5: 27-Jan W7: 10-Feb W9: 24-Feb W11: 09-Mar W13: 23-Mar W15: 06-Apr W17: 20-Apr W19: 04-May W21: 18-May W37: 7-Sep W33: 10-Aug W35: 24-Aug W1: 30-Dec W23: 01-Jun W25: 15-Jun W27: 29-Jun W29: 13-Jul W31: 27-Jul -40% Mar Apr Jan May Jul Jun Feb Week Starting Dates Month Week Starting Dates Italy Germany Spain France UK *Units Growth Latest week 2020 vs. 2019; Source: IQVIA weekly sell out data – Week 1 2020 starting 30/12/2019 | Retail pharmacy panel – captures sales of products at retail pharmacies COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 18
F2F rep activity was replaced by remote contacts in April-May: F2F rep activity started to recover in EU5, August showed holiday impact EU5 – Number of face to face detailing and meeting contacts EU5 – Number of remote detailing and meeting contacts 4.5 1.4 4.2Mn 1.3 4.0 1.2 3.5 1.1 1.0 3.0 0.9Mn 0.9 2.5 2.3Mn 0.8 0.7 2.0 1.7Mn 0.6 1.5 1.3Mn 0.5 1.1Mn 0.4 1.0 0.3 0.2Mn 1.0Mn 0.3Mn 0.5Mn 0.2 0.2Mn 0.5 0.4Mn 0.5Mn 0.1Mn 0.1Mn 0.1 0.0Mn 0.2Mn 0.0 0.0 0.1Mn May-2020 Aug-2020 Feb-2020 Mar-2020 Jun-2020 Jan-2020 Apr-2020 Feb-2020 Apr-2020 Jul-2020 Aug-2020 Jan-2020 May-2020 Jun-2020 Mar-2020 Jul-2020 0.1Mn France Germany Italy Spain UK France Germany Italy Spain UK Source: Channel Dynamics; F2F includes detailing and meetings; Jan – Aug 2020, compared with the same period in 2019 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 19
We also see that nearly 40-50% of HCP’s in EU & US have indicated that virtual interactions will be sufficient in the future Ratings of HCP satisfaction with virtual detailing HCP satisfaction with virtual detailing Top 7 developed – July 2020 8.7% 18.3% 25.0% Thinking about a post-COVID-19 crisis context, 22.7% please indicate your level of agreement with the following statement: 26.2% 28.9% “Remote interactions with pharma representatives via online tools such as Skype, Zoom, Webex… will be sufficient in meeting my needs for up to date and relevant 68.6% drug treatment information” 55.5% 46.1% Scored 0-10 EU5 US Japan Completely Agree (9-10) Somewhat Agree (7-8) Disagree (0-6) Source: IQVIA Channel Dynamics Channel Preference Survey July 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 20
The Italian prescription, hospital and consumer health markets have seen signs of recovery in recent weeks % Growth in Units – Rx retail market, Hospital market, Consumer Health market Retail Rx market Hospital market Consumer Health market % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same week 2019 Top 5* YTD month 2019 Top 5* YTD week 2019 Consumer health categories 120% 40% 120% 100% 30% 100% 80% 20% 80% % Growth – Units % Growth – Units % Growth – Units 60% 10% 60% 40% 0% 40% 20% -10% 20% 0% -20% 0% -20% -30% -20% -40% -40% -40% W11: 09-Mar W13: 23-Mar W37: 7-Sep W3: 13-Jan W5: 27-Jan W7: 10-Feb W9: 24-Feb W15: 06-Apr W17: 20-Apr W19: 04-May W21: 18-May W23: 01-Jun W25: 15-Jun W27: 29-Jun W29: 13-Jul W31: 27-Jul W33: 10-Aug W35: 24-Aug W1: 30-Dec W11: 09-Mar W13: 23-Mar W37: 7-Sep W3: 13-Jan W5: 27-Jan W21: 18-May W7: 10-Feb W9: 24-Feb W15: 06-Apr W17: 20-Apr W19: 04-May W29: 13-Jul W31: 27-Jul W23: 01-Jun W25: 15-Jun W27: 29-Jun W33: 10-Aug W35: 24-Aug W1: 30-Dec Mar Apr Jan May Jun Jul Feb Month Week Starting Dates Week Starting Dates Antineoplastic and immunomodulating agents Antineoplastic and immunomodulating agents Musculo-skeletal system Over-the-Counter Drugs (OTC) Nervous system Nervous system Personal Care (PEC) Cardiovascular system Systemic hormonal preparations… Systemic Anti-Infectives Patient Care (PAC) Genito-urinary system and sex hormones Blood and blood forming organs Nutrition (NTR) *Top in terms of YTD Growth; Units Growth Latest week 2020 vs. 2019; Source: IQVIA weekly sell out data – Week 1 2020 starting 30/12/2019 | Retail pharmacy panel – captures sales of products at retail pharmacies COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 21
The overall promotional volume in Italy is still slightly lower (-9%) compared to 2019 with F2F detailing recovering to 69% of total contact volume Promotional volume share and growth Promotional volume share by channel % Change in promotional volume by channel September* 2019 – September* 2020 -30% -15% 152% 69% 89% 171% 875% 177% 6% 9% 27% channels 2% total 3% 15% All -9% 1% 5% 1% September September 2019 2020 F2F Detailing E-Detailing E-meetings Postal Mailing F2F Meeting Phone Detailing E-mail *30 day period to 13/09 Source: IQVIA European Thought Leadership; ChannelDynamics 13/09/2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 22
In Germany, sales growth for the Dermatological class within Retail has increased in recent weeks % Growth in Units – Rx retail market, Hospital market, Consumer Health market Retail Rx market Hospital market Consumer Health market % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same week 2019 Top 5* YTD month 2019 Top 5* YTD week 2019 Consumer health categories 120% 15% 120% 100% 10% 100% 5% 80% 80% % Growth – Units % Growth – Units % Growth – Units 0% 60% -5% 60% 40% -10% 40% 20% -15% 20% -20% 0% 0% -25% -20% -30% -20% -40% -35% -40% Mar Apr May Jan Jun Jul Feb W3: 13-Jan W5: 27-Jan W15: 06-Apr W17: 20-Apr W7: 10-Feb W9: 24-Feb W11: 09-Mar W13: 23-Mar W19: 04-May W21: 18-May W37: 7-Sep W33: 10-Aug W35: 24-Aug W29: 13-Jul W31: 27-Jul W1: 30-Dec W23: 01-Jun W25: 15-Jun W27: 29-Jun -60% W3: 13-Jan W5: 27-Jan W7: 10-Feb W9: 24-Feb W11: 09-Mar W13: 23-Mar W15: 06-Apr W17: 20-Apr W19: 04-May W21: 18-May W37: 7-Sep W29: 13-Jul W31: 27-Jul W33: 10-Aug W35: 24-Aug W1: 30-Dec W23: 01-Jun W25: 15-Jun W27: 29-Jun Month Week Starting Dates Antineoplastic and immunomodulating agents Antineoplastic and immunomodulating agents Week Starting Dates Dermatologicals Blood and blood forming organs Over-the-Counter Drugs (OTC) Cardiovascular system Systemic Anti-Infectives Personal Care (PEC) Systemic hormonal preparations… Nervous system Patient Care (PAC) Blood and blood forming organs Cardiovascular system Nutrition (NTR) *Top in terms of YTD Growth; Units Growth Latest week 2020 vs. 2019; Source: IQVIA weekly sell out data – Week 1 2020 starting 30/12/2019 | Retail pharmacy panel – captures sales of products at retail pharmacies COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 23
The overall promotional volume in Germany is nearly back to pre COVID-19, with majority share contributed by Postal Mailing and E-mails Promotional volume share and growth Promotional volume share by channel % Change in promotional volume by channel September* 2019 – September* 2020 -33% 23% 34% -56% 2% 1% 1% 385% 1% 1% 18% 11% 138% 1,238% 67% 53% 55% 2% channels total All -2% September September 2019 2020 F2F Detailing E-Detailing E-meetings Postal Mailing F2F Meeting Phone Detailing E-mail *30 day period to 13/09 Source: IQVIA European Thought Leadership; ChannelDynamics 13/09/2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 24
Over the past few weeks, the Spanish retail prescription market trends have remained relatively unchanged while hospital market is increasing % Growth in Units – Rx retail market, Hospital market, Consumer Health market Retail Rx market Hospital market Consumer Health market % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same week 2019 Top 5* YTD month 2019 Top 5* YTD week 2019 Consumer health categories 120% 40% 120% 100% 30% 100% 80% 20% 80% % Growth – Units % Growth – Units % Growth – Units 60% 10% 60% 40% 0% 40% 20% -10% 20% 0% -20% 0% -20% -30% -20% W37: 7-Sep W11: 09-Mar W13: 23-Mar W3: 13-Jan W5: 27-Jan W7: 10-Feb W9: 24-Feb W15: 06-Apr W17: 20-Apr W19: 04-May W21: 18-May W29: 13-Jul W31: 27-Jul W33: 10-Aug W35: 24-Aug W1: 30-Dec W23: 01-Jun W25: 15-Jun W27: 29-Jun -40% -40% -50% -60% W11: 09-Mar W13: 23-Mar W37: 7-Sep W3: 13-Jan W5: 27-Jan W15: 06-Apr W17: 20-Apr W19: 04-May W21: 18-May W7: 10-Feb W9: 24-Feb W29: 13-Jul W31: 27-Jul W23: 01-Jun W25: 15-Jun W27: 29-Jun W33: 10-Aug W35: 24-Aug W1: 30-Dec Apr May Mar Jan Jun Jul Feb Week Starting Dates Month Nervous system Antineoplastic and immunomodulating agents Week Starting Dates Antineoplastic and immunomodulating agents Dermatologicals Over-the-Counter Drugs (OTC) Cardiovascular system Systemic Anti-Infectives Personal Care (PEC) Alimentary tract and metabolism Genito-urinary system and sex hormones Patient Care (PAC) Blood and blood forming organs Musculo-skeletal system Nutrition (NTR) *Top in terms of YTD Growth; Units Growth Latest week 2020 vs. 2019; Source: IQVIA weekly sell out data – Week 1 2020 starting 30/12/2019 | Retail pharmacy panel – captures sales of products at retail pharmacies COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 25
Spain’s overall promotional volume is much lower (-27%) as compared to the same period in 2019 Promotional volume share and growth Promotional volume share by channel % Change in promotional volume by channel September* 2019 – September* 2020 -75% 29% -58% 230% 84% 23% 366% 3,500% 26% 147% 1% 110% channels 5% 19% total 4% All 6% -27% 1% 2% September September 2019 2020 F2F Detailing E-Detailing E-meetings Postal Mailing F2F Meeting Phone Detailing E-mail *30 day period to 13/09 Source: IQVIA European Thought Leadership; ChannelDynamics 13/09/2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 26
The French retail Rx market is relatively stable, except for trend breaks in holiday weeks while hospital market has shown a decrease in July ‘20 % Growth in Units – Rx retail market, Hospital market, Consumer Health market Retail Rx market Hospital market Consumer Health market % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same week 2019 Top 5* YTD month 2019 Top 5* YTD week 2019 Consumer health categories 120% 20% 160% 100% 15% 140% 80% 10% 120% % Growth – Units % Growth – Units % Growth – Units 5% 100% 60% 80% 0% 40% 60% -5% 40% 20% -10% 20% 0% -15% 0% -20% -20% -20% -40% W3: 13-Jan W5: 27-Jan W11: 09-Mar W13: 23-Mar W37: 7-Sep W7: 10-Feb W9: 24-Feb W15: 06-Apr W17: 20-Apr W19: 04-May W21: 18-May W29: 13-Jul W31: 27-Jul W23: 01-Jun W25: 15-Jun W27: 29-Jun W33: 10-Aug W35: 24-Aug W1: 30-Dec -40% -25% W37: 7-Sep W11: 09-Mar W13: 23-Mar W3: 13-Jan W5: 27-Jan Mar Apr May W7: 10-Feb W9: 24-Feb W15: 06-Apr W17: 20-Apr W19: 04-May W21: 18-May W29: 13-Jul W31: 27-Jul W33: 10-Aug W35: 24-Aug Jan Jun Jul W1: 30-Dec W23: 01-Jun W25: 15-Jun W27: 29-Jun Feb Month Week Starting Dates Week Starting Dates Antineoplastic and immunomodulating agents Antineoplastic and immunomodulating agents Blood and blood forming organs Alimentary tract and metabolism Over-the-Counter Drugs (OTC) Cardiovascular system Cardiovascular system Personal Care (PEC) Nervous system Blood and blood forming organs Patient Care (PAC) Alimentary tract and metabolism Systemic Anti-Infectives Nutrition (NTR) *Top in terms of YTD Growth; Units Growth Latest week 2020 vs. 2019; Source: IQVIA weekly sell out data – Week 1 2020 starting 30/12/2019 | Retail pharmacy panel – captures sales of products at retail pharmacies COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 27
In France, the overall promotional volume is still lower (-9%) compared to 2019 with significant increase in share of E-mails (49%) Promotional volume share and growth Promotional volume share by channel % Change in promotional volume by channel September* 2019 – September* 2020 -31% 32% -60% 42% 1% 1% 165% 3% 0% 2% 0% 1% 50% 260% 34% 49% 32% -39% channels 20% total All 13% -9% September September 2019 2020 F2F Detailing E-Detailing E-meetings Postal Mailing F2F Meeting Phone Detailing E-mail *30 day period to 13/09 Source: IQVIA European Thought Leadership; ChannelDynamics 13/09/2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 28
The UK prescription market has been quite stable over the past two months while hospital market showed a sharp increase in the month of June 2020 % Growth in Units – Rx retail market, Hospital market, Consumer Health market Retail Rx market Hospital market Consumer Health market % Growth – Weekly Rx in 2020 vs. Avg. % Growth – Units in 2020 vs. same % Growth – Units in 2020 vs. same weekly Rx in Jan 2020 month 2019 Top 5* YTD week 2019 Consumer health categories 120% Top 5* ATC classes 120% 120% 100% 100% 100% 80% 80% 80% % Growth – Units % Growth – Units % Growth – Units 60% 60% 60% 40% 40% 40% 20% 20% 20% 0% 0% 0% -20% -20% -20% W19: 04-May W21: 18-May W33: 10-Aug W35: 24-Aug W37: 7-Sep W7: 10-Feb W9: 24-Feb W11: 09-Mar W13: 23-Mar W15: 06-Apr W17: 20-Apr W29: 13-Jul W31: 27-Jul W23: 01-Jun W25: 15-Jun W27: 29-Jun -40% -40% Mar Apr Jan May Jun Jul Feb -60% W37: 7-Sep W11: 09-Mar W13: 23-Mar W3: 13-Jan W5: 27-Jan W7: 10-Feb W9: 24-Feb W15: 06-Apr W17: 20-Apr W19: 04-May W21: 18-May W29: 13-Jul W31: 27-Jul W33: 10-Aug W35: 24-Aug W1: 30-Dec W23: 01-Jun W25: 15-Jun W27: 29-Jun Week Starting Dates Month Respiratory system Antineoplastic and immunomodulating agents Week Starting Dates Antineoplastic and immunomodulating agents Musclo-skeletal system Over-the-Counter Drugs (OTC) Cardiovascular system Antiparasitic products, insecticides and repellents Personal Care (PEC) Blood and blood forming organs Cardiovascular system Patient Care (PAC) Alimentary tract and metabolism Blood and blood forming organs Nutrition (NTR) *Top in terms of YTD Growth; Units Growth Latest week 2020 vs. 2019; Source: IQVIA weekly sell out data – Week 1 2020 starting 30/12/2019 | Retail pharmacy panel – captures sales of products at retail pharmacies COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 29
In the UK, overall promotion has shown positive growth compared to 2019 with majority share contributed by E-mails and Postal mailing Promotional volume share and growth Promotional volume share by channel % Change in promotional volume by channel September* 2019 – September* 2020 3% 1% 6% -89% 28% 8% 3% -59% 1% 3% 419% 2% 296% 51% 31% 2,818% 83% 33% -7% channels 27% total All 12% September September 2019 2020 F2F Detailing E-Detailing E-meetings Postal Mailing F2F Meeting Phone Detailing E-mail *30 day period to 13/09 Source: IQVIA European Thought Leadership; ChannelDynamics 13/09/2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 30
Agenda 1 Taking stock: An assessment of 2020 for the EU5 pharma market 2 Latest Sales Trends & HCP engagement across the EU5 Countries 3 Lessons for 2021 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 31
We are only at the beginning of the economic crisis and the extended healthcare system crisis We face a dual challenge: Health systems are both strained Healthcare systems Payer constraints and constrained stretched Patient out of pocket Uncertainty and risk constraints Economic Healthcare crisis system crisis (2008-13, (2020-) 2020--) Public investment Increasingly remote challenges healthcare provision Private investment Risk and uncertainty enhancers: Different strategic challenges • Second/extended waves healthcare priorities • Timing and success of vaccine deployment • Healthcare system constraints and resilience • Depth/duration of economic crisis COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 32
Pharma will need to adapt to thrive, and the strategic plan for 2020s must be revised across the value chain COVID impact timing COVID impact focus ✓ Local precision and coordination GTM Model Near term ✓ Call-center based remote engagement ✓ Scientific/clinically focused field-team Patient ✓ Enhance support for patients within new care sites Support and Near term ✓ Strengthen pathways and guidelines to empower patients in care seeking behaviors Engagement ✓ Remote monitoring and tele-health continuation ✓ Plan for new evidence requirements Pricing and Near term ✓ Accelerated focus on value demonstration Market Access ✓ Regulators more responsive to change Regulatory/ Near/mid term ✓ Long-term follow-up COVID-19 patients Safety ✓ Evidence on COVID-19 impact Near term (execution) ✓ Refocus portfolio strategy on high-unmet need areas R&D/Portfolio Long term (portfolio ✓ Innovative use of RW evidence Strategy choice) ✓ Tech-enabled execution Supply and ✓ Consider domestic/collaborative manufacturing to prevent any supply issues or Mid/long term Manufacturing policy changes COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 33
Three focus areas will redefine how companies prepare for excellent launch Patient HCP Evidence journey engagement and value • A backlog of undiagnosed and treated • HCP/pharma engagement volume fell • Payers budget pressured in the coming patients must be addressed and went remote – with recovery, economic crisis and will raise the bar of engagement mix is still more remote evidence for access • Opportunities for patients to receive new or switch prescriptions must be rebuilt • HCPs are time pressured as they • Meaningful engagement with HCPs and address ongoing pandemic crisis and health systems needs a strong stream of • Some patient movement to remote treatment backlogs effective RWE demonstrating utility and treatment will be permanent value in post pandemic environment • HCPs expect patient treatment pattern change and look to pharma for support COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 34
Excellent launches had a significantly higher share of digital promotion in our COVID-19 world Overall levels of digital promotion have increased since 2018, but the conclusion remains 2018 Study 2020 Study Avg. digital share of promo volume across 1st four quarters Avg. digital share of promo volume across 1st four quarters following launch following launch Top 7 developed: New Active Substances 2012-2016 Top 7 developed: New Active Substances 2014-2018 30% 30 30 25 25 24% 22% 20 20 18% 16% 15 13% 15 10 10 5 5 0 0 International All Other Specialty All Other Primary Care All other Top Sellers Launches International Specialty International Primary Care (All Specialty) Top Sellers Launches Top Sellers Launches Source: IQVIA European Thought Leadership; ChannelDynamics Q3 2017; MIDAS Q3 2017; ChannelDynamics MAT Q1 2020; MIDAS MAT Q1 2020; Rx-only COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 35
COVID-19 is an accelerator of change – the longer restrictions and uncertainty prevail, the more drastic change can be expected COVID-19 crisis caused significant decline in patient load and a diagnosis backlog, impacting new treatments and switches, and implications for the launches entering the market in 2020 and beyond Risk and uncertainty challenges forward planning. Healthcare system fragility, limits pharma’s ability to interact with physicians at a time where its support with information and services essential Long-term economic crisis will pressure healthcare budgets and require more compelling product evidence, and pharma services for HCPs and patients navigating healthcare system change A massive reduction of F2F interactions, and growth remote HCP-patient and pharma-HCP interaction – recent experience increases digital capabilities and acceptance of digital engagement Pharma needs to adapt team structures, capabilities, processes and tools to become more agile, digitally savvy, more precise and faster in decision making COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 36
Q&A Sarah Rickwood, Natalie Harb Vice President, Senior Principal, European Marketing and Thought Leadership Global Analytics Solutions © 2020. All rights reserved. IQVIA® is a registered trademark of IQVIA Inc. in the United States, the European Union, and various other countries. 37
Upcoming Webinar’s • We will continue with our monthly webinars and below we have outlined the key themes & dates for each webinars: - 20th Oct: COVID-19 Implications on the Dynamic Market and Patient Backlog - 24th Nov: Pandemic Impact on Innovative Launch and Launch Excellence Post Pandemic • In October’s webinar we will also be sharing results from our 3rd survey that looks at the Impact of COVID-19 on Cancer Treatment across the EU 5 countries For more information on IQVIA’s COVID-19 perspectives, please visit: https://www.iqvia.com/solutions/commercialization/covid-19-and-commercialization COVID-19 Market Impact - Cross Country Report - 28th September 2020 | Copyright 2020 IQVIA. All rights reserved. 38
Appendix 39
The EU5 countries also exhibited similar trends of pandemic pharma sales with varying degrees across the countries Pharma Sales in Standard Units – Retail + Hospital market Pharma sales in Italy (Mn SU/day) Pharma sales in Germany (Mn SU/day) Pharma sales in Spain (Mn SU/day) 250 250 250 200 200 200 150 150 150 100 100 100 50 50 50 0 0 0 Mar-19 Sep-19 Nov-19 Mar-20 Mar-19 Sep-19 Nov-19 Mar-20 Mar-19 Sep-19 Nov-19 Mar-20 Jan-19 May-19 Jul-19 Jan-20 May-20 Jul-20 Jan-19 May-19 Jul-19 Jan-20 May-20 Jul-20 Jan-19 May-19 Jul-19 Jan-20 May-20 Jul-20 Pharma sales in France (Mn SU/day) Pharma sales in UK (Mn SU/day) 250 250 200 200 150 150 100 100 50 50 0 0 Mar-19 Mar-20 Mar-19 Mar-20 Sep-19 Nov-19 Sep-19 Nov-19 Jan-19 May-19 Jul-19 Jan-20 May-20 Jul-20 Jan-19 May-19 Jul-19 Jan-20 May-20 Jul-20 Source: IQVIA European Thought Leadership, MIDAS MTH Jun 2020 COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 40
Thank You
Appendix: Data Sources and Methodology 42
IQVIA Sales Data Offerings Used and Methodology (1/2) Geographic scope of Measures used Data source Frequency Data source description Calculations applied data used in this report for analysis Weekly Sell-out Weekly Details on sales of products • Italy: Rx and CH • Italy: Units Italy, Germany, Spain, France: Data dispensed at retail pharmacies markets • Germany: Units • Units Growth Jan 2020 vs 2019 – To provide (Pharmatrend, This includes both prescription • Germany: Rx and CH base view of the market from pre COVID-19 Flashtrend) • Spain: Units and non-prescription products markets period in the year 2020 • France: Units Prescription products are • Spain: Rx and CH • Units Growth Latest week 2020 vs 2019 – classified using ATC markets • UK: Rx counts To provide the latest trend in the market to classification understand the dynamic changes in trends • France: Rx and CH Consumer health products markets • Units Growth YTD 2020 vs 2019 – To provide cover products from Over the the YTD trend in the market to understand the • UK: Rx market Counter drugs, Personal Care, longer term changes in trends Patient Care and Nutrition UK: Rx market categories • Rx Growth Latest week Rx 2020 vs Average Rx for Jan 2020 – To provide comparison of latest market scenario against Jan 2020 (pre COVID-19 period) as base where 2019 data was unavailable • Rx Growth YTD average weekly Rx 2020 vs Average weekly Rx for Jan 2020 – To provide comparison of YTD sales trends in 2020 against Jan 2020 (pre COVID-19 period) as base where 2019 data was unavailable COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 43
IQVIA Sales Data Offerings Used and Methodology (2/2) Geographic scope of Measures used Data source Frequency Data source description Calculations applied data used in this report for analysis Weekly Sell-in Weekly Details on purchase of • UK consumer health • UK: Units UK: CH market Data products by retail pharmacies market • Units Growth Jan 2020 vs 2019 – To provide Our current scope covers base view of the market from pre COVID-19 consumer health products only period in the year 2020 • Units Growth Latest week 2020 vs 2019 – To provide the latest trend in the market to understand the dynamic changes in trends • Units Growth YTD 2020 vs 2019 – To provide the YTD trend in the market to understand the longer term changes in trends MIDAS Data Monthly Details on hospital panel retail • Italy hospital market • Italy: Units Italy, Germany, Spain, France, UK: sales • Germany hospital • Germany: Units • Units Growth Jan 2020 vs 2019 – To provide market base view of the market from pre COVID-19 • Spain: Units period in the year 2020 • Spain hospital market • France: Units • Units Growth Latest month 2020 vs 2019 – • France hospital market • UK: Units To provide the latest trend in the market to • UK hospital market understand the dynamic changes in trends • Units Growth YTD 2020 vs 2019 – To provide the YTD trend in the market to understand the longer term changes in trends COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 44
Sources from secondary data research Number of Reported COVID-19 Infections in EU5 (Slide 15) Italy: • Center for System Science and Engineering (CSSE) at John Hopkins University (JHU) • The Civil Protection Department, Govt of Italy http://www.protezionecivile.it/attivita-rischi/rischio-sanitario/emergenze/coronavirus Germany: • Center for System Science and Engineering (CSSE) at John Hopkins University (JHU) • Robert Koch-Institut https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Fallzahlen.html Spain: • Center for System Science and Engineering (CSSE) at John Hopkins University (JHU) • Ministerio de Sanidad, Consumo y Bienestar Social, Govt of Spain https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/situacionActual.htm France: • Center for System Science and Engineering (CSSE) at John Hopkins University (JHU) • Santé Publique France, Govt of France https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/articles/infection-au-nouveau- coronavirus-sars-cov-2-covid-19-france-et-monde UK: • Center for System Science and Engineering (CSSE) at John Hopkins University (JHU) • Department of Health and Social Care and Public Health England, Govt of UK https://www.gov.uk/guidance/coronavirus-covid-19-information-for-the-public#number-of-cases Please note: IQVIA is not accountable for the accuracy of information from external data sources COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 45
Sources from secondary data research COVID-19 patient insights (Slide 16) Italy: • https://www.epicentro.iss.it/ • http://www.salute.gov.it/portale/news/p3_2_1_1_1.jsp?lingua=italiano&menu=notizie&p=dalministero&id=5057 • http://www.salute.gov.it/nuovocoronavirus • https://www.epicentro.iss.it/en/coronavirus/bollettino/Report-COVID-2019_7_september_2020.pdf • Center for System Science and Engineering (CSSE) at John Hopkins University (JHU): https://coronavirus.jhu.edu/ Germany: • https://www.rki.de/DE/Content/InfAZ/N/Neuartiges_Coronavirus/Situationsberichte/Gesamt.html?nn=13490888 • Center for System Science and Engineering (CSSE) at John Hopkins University (JHU): https://coronavirus.jhu.edu/ Spain: • https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/EnfermedadesTransmisibles/Paginas/InformesCOVID-19.aspx • https://cnecovid.isciii.es/covid19/ • https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov/documentos/Actualizacion_209_COVID-19.pdf • Center for System Science and Engineering (CSSE) at John Hopkins University (JHU): https://coronavirus.jhu.edu/ France: • https://www.santepubliquefrance.fr/recherche/#search=COVID%2019%20%20%20point%20epidemiologique&publications=donn%C3%A9es®ions=National&sort=date • Center for System Science and Engineering (CSSE) at John Hopkins University (JHU): https://coronavirus.jhu.edu/ Please note: IQVIA is not accountable for the accuracy of information from external data sources COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 46
Channel Definitions (Slides 22,24,26,28,30) F2F Detailing: Sales Rep face-to-face detailing Face to face interactions F2F Meetings: Meetings, events, congresses, seminars E-Detailing: Online presentations - live with a rep or automated, self guided Phone Detailing: Telephone communication with reps Remote E-Meetings: Streaming video – live webinar or pre-recorded webcast interactions Email: Opened email communication Postal: Opened paper mail received by post COVID-19 EU5 Webinar – Sept 2020| Copyright 2020 IQVIA. All rights reserved. 47
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