Research Report - Human Performance Laboratory - University of Calgary
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2019 might go into the records as the year before everything changed, the year before the pandemic. I send my sincere wish to all of you that you, your families, friends, and colleagues are healthy and safe. 2019 was altogether different than the times we live in now, and I want to re- mark on two extraordinary things directly related to the Human Performance Lab (HPL) and its global reach: (i) the ranking of the Faculty of Kinesiology globally, and (ii) the Congress of the International and the American Societies of Biomechanics. Faculty of Kinesiology Ranking: Shanghai Ranking Consultancy is an independ- ent organization dedicated to research on higher education. It ranks special fo- cus institutions, and among them the hundreds of schools, faculties, and depart- ments of sport science. For 2019, the Faculty of Kinesiology at the University of Calgary was ranked 7th globally and 1st in North America in the Sport Science category. Much of this success can be traced to the excellence and dedication of faculty members, students, trainees, technicians, and research assistants of the Human Performance Lab, which in turn is a direct reflection of the investment of our faculty and the university into the HPL. Our gratitude and thanks go to them. We are proud to contribute to the success and reputation of our faculty and University. Congress of the International and American Societies of Biomechanics: In 2016 we made the successful bid to host the 2019 congress of the International Soci- ety of Biomechanics (ISB), and exactly three years later, the opening ceremony of ISB2019 took place in Calgary’s Convention Centre. ISB2019 was joined by the annual conference of the American Society of Biomechanics, which made the event the biggest and most important for biomechanics research in 2019. Members of the biomechanics group of the HPL hosted the event, and members from other disciplines organized special symposia, helped with fundraising, and served among the contingent of over 100 volunteers that were required every day. It was a true team effort. The ISB/ASB 2019 congress was not only the big- gest ever, it was also a resounding scientific and social success, and most of all, a lot of fun. Having been in self-isolation for three months now due to the coro- navirus, I am reminiscent of those five days in August of last year, with crowded poster sessions and rooms filled to capacity, never ending discussions late into the night, dinners with friends, the banquet and the dancing, without fear, with- out restriction. That is what scientific conferences are all about. Let us hope we will meet again soon, in person and personally. Two global events, two global successes. It was another eventful and exciting year for the HPL. My thanks go to the International and American Societies of Biomechanics for allowing us to host ISB/ASB 2019, and to the University of Calgary, the Faculty of Kinesiology, and all departments and sponsors of ISB/ ASB 2019. It was a pleasure and privilege to be your host. My final thanks go to our families, friends, and supporters of the HPL. Your continued engagement and dedication, and your undeterred belief that we can be global leaders in hu- man health wellness and performance research is needed more today than ever before. Annual Report 2019 1
Highlights Honour Preston Wiley — Calgary Booster Club, Honoured Athletic Leader Award Appointed Zachary Barrons — Informatics Officer, Footwear Biomechanics Groups Appointed Salvatore Federico — Past President of the Canadian Society for Biomechanics (2019-2020 term) Appointed Salvatore Federico — Member, Selection Committee, Society for Natural Philosophy (not listed in 2018) Appointed Salvatore Federico — Member, Editorial Advisory Board, Atti dell’Accademia Peloritana dei Pericolanti Appointed Salvatore Federico — Member, NSERC Discovery, Evaluation Group in Mechanical Engineering Appointed Bill Wannop — Associate Editor, Footwear Science Appointed Bill Wannop — Awards Officer, Footwear Biomechanics Group Award Joshua Cashaback — Alberta Innovates Health Solutions (AIHS) Postdoctoral Fellowship. Controlling and adapt- ing our movements in the prescence of muscle fatigue Award Mathieu Chin — 3M National Student Fellowship Award Carolyn Emery, Carla van den Berg, Sarah Richmond, Luz Palacios-Derflingher, Carly McKay, Patricia K Doyle- Baker, M McKinlay, Clodagh Toomey, A Nettel-Aguirre, Brent Hagel — Best Podium Presentation Awards. ‘Implementing a school prevention program to reduce injuries through neuromuscular training (isprint): a clus- ter-randomized controlled trial’. Third World Congress of Sport Physical Therapy, Vancouver, BC. October. Award Salvatore Federico – 2018-2019 Teaching Achievement Award, Schulich School of Engineering, The University of Calgary Award Reed Ferber — Great Supervisor Award, University of Calgary Award Ifaz T. Haider — Tim Murray Short Term Training Award, Osteoporosis Canada 2 Human Performance Laboratory
Highlights Award Jeff Ilg — Podium Presentation Award, McCaig Summer Student Symposium, Calgary, AB Award Lindsay Loundagin — Young Investigator Award, 22nd International Workshop on Quantitative Musculoskeletal Imaging Award Shyamchand Mayengbam — Metabolics Association of North America, Early Career Award Award Ryan Miller — Best Poster Award, ‘Modulation of the Nervous System during an Unpredictable Posture Task’. Campus Alberta Student Conference in Health, Edmonton, AB Award Sadhiq Nazeer — Winner, Faculty of Kinesiology Award, University of Calgary Undergraduate Research Symposium Award Eng Kuan Moo — Promising Young Scientist Award, International Society of Biomechanics Conference 2019, Calgary, AB Award Rob Moore — Best Presentation Award, ‘Adaptations to Novel Visuomotor Rotations After Stroke’. Alberta Biomedical Engineering Conference (Alberta BME), Banff, AB Award Jaqueline Rios — J.B. Hyne Research Innovation Award Award Jonathan Smirl — Michael Smith Foundation for Health Research: Post-Doctoral Fellowship Award Baaba Otoo — David Winter Young Investigator Award (Poster), International Society of Biomechanics Conference, Calgary, AB Award Tessa VanDerVeeken — Tim Murray Short Term Training Award, Osteoporosis Canada Award Valeriya Volkova — 2019 Best Presentation Award, UBC Wearable Summer School Ph.D. Osman Darici – Supervisor: Dr. Art Kuo. Thesis: Uneven Terrain Human Walking Annual Report 2019 3
Highlights Ph.D. Breda Eubank (Lau) — Supervisors: Drs. Preston Wiley and Mark Lafave. Thesis: Development of a Clinical Pathway for Patients with Chronic Rotator Cuff Tears (2018) Ph.D. Christian Clermont — Supervisor: Dr. Reed Ferber. Thesis: Making Sense of Sensor Data for Recreational and Competitive Runners: Detecting Typical and Atypical Running Biomechanics Ph.D. Danilo Iannetta — Supervisor: Dr. Juan Murias. Thesis: Identifying Exercise Intensity “Thresholds”: Implications for Metabolic Responses, Performance, and Exercise Intensity Prescription Ph.D. Teja Klancic — Supervisor: Dr. Raylene Reimer. Thesis: Early Life Antibiotic and Prebiotic Exposure: Impact on Gut Microbiota, Metabolism and Obesity Risk Ph.D. Jodi Nettleton — Supervisor: Dr. Raylene Reimer. Thesis: Dietary Modulators of Gut Microbiota: Impact on Metabolic Health and Behaviour Ph.D. Jacqueline Lourdes Rios — Supervisor: Dr. Walter Herzog. Thesis: Exercise and Dietary Interventions in a Rat Model of Metabolic Knee Osteoarthritis Ph.D. Rogerio Soares — Supervisor: Dr. Juan Murias. Thesis: The Use of Near-Infrared Spectroscopy for Microvascular Function Assessment in Healthy and With Obesity Individuals During Normo-and Hyperglycemia PhD. Mawafag Alhasadi — Supervisor: Salvatore Federico – Thesis: Effect of Defects, Inclusions and Inhomogeneities in Elastic Solids M.Sc. Kimberley Befus — Supervisors: Drs. Carolyn Emery and Meghan McDonough. Thesis: Motivation and Social Factors Associated with Exercise Fidelity in a Basketball Neuromuscular Training Prevention Warm-Up in Youth M.Sc. Alexander Chen — Supervisor: Dr. Brian MacIntosh. Thesis: Developing Procedures and Software for Correcting Artifacts in Motion Data 4 Human Performance Laboratory
Highlights M.Sc. Chevonne Codd — Co-Supervisor: Drs. Kathryn Schneider and Carolyn Emery. Thesis: Incidence, Risk Factors, and Mechanisms of Concussion and Musculoskeletal Injury in Youth Soccer Players M.Sc. Laura Crack — Supervisor: Dr. Patricia Doyle-Baker. Thesis: CHESS: Changes in Hormones with Exposure to Student Stress M.Sc. Tessa Gallinger — Supervisors: Drs. Brian MacIntosh and Jared Fletcher. Thesis: Muscle Length Adaptations to High-Velocity Training in Young Adults with Cerebral Palsy M.Sc. Colin Lavigne — Supervisors: Drs. Guillaume Millet and Nicole Culos-Reed. Thesis: The Effect of Radiation Therapy and a 12-week Novel Strength Training Intervention on Neuromuscular Function and Fatigability in People Diagnosed with Head & Neck Cancer M.Sc. Lauren Miutz — Supervisor: Dr. Kathryn Schneider. Thesis: Feasibility, Reliability and Concurrent Validity of a Field Test of Exertion in High School Students M.Sc. Ahmad Qahtan — Supervisor: Dr. Juan Murias. Thesis: Effects of a Single-Leg Exercise Training Intervention on Single and Double Leg Peak Power Output, Maximal Oxygen Consumption, Gas Exchange Threshold, and the Respitory Compensation Point M.Sc. Elysa Sandron — Supervisors: Drs. Carolyn Emery and Elizabeth Condliffe. Thesis: Adapted Sport and Recreation Summer Camp: Youth with Physical Disabilities, Their Parents and Staff Perspectives on Psychosocial Outcomes and Physical Activity Participation Annual Report 2019 5
General Comments Movement Science the function of neural circuits that and Musculoskeletal support motor behaviour, and Health 4) identifying how impairments in sensory and motor function Tyler Cluff caused by stroke and concussion influence sensorimotor control Integrative Sensorimotor and learning. Through our basic Neuroscience Laboratory science program and ongoing col- laborations, we hope to generate tools that allow us to better assess, monitor and diagnose deficits in sensory and motor function. Brent Edwards Mechanical fatigue of load bearing biological tissue is an inevitable consequence of physical activity. Over time, habitual loading of the We are a growing group in the musculoskeletal system causes Human Performance Laboratory. microdamage accumulation that Our work is focused on the mech- reduces the overall quality of the nistic, multidisciplinary study of tissue and leads to a reduction human sensorimotor control and in stiffness and an increase in learning. We combine behavioural mechanical strain with continued experiments with robotics, neuro- loading. Without adequate tis- stimulation, medical imaging, and sue repair and adaptation, the computational models to examine evolution and accumulation of the function of the human sensory microdamage may eventually and motor systems. Our work is lead to musculoskeletal injury. focused on understanding how Mechanical fatigue is believed basic aspects of sensory process- to play a predominant role in ing contribute to human motor the pathophysiology of muscu- control and learning. loskeletal injuries such as bone Ongoing projects in the lab focus stress fracture as well as Achilles on four topics: 1) the role of and patellar tendinopathy. Our sensory feedback in the selection, research combines biomechanical planning, and control of voluntary experimentation with advanced movements, 2) basic principles of medical imaging and computa- sensory processing and how they tional modeling to investigate impact individual patterns of hu- tissue damage and fatigue in man motor behaviour, 3) probing response to mechanical loading. 6 Human Performance Laboratory
General Comments Our unique approach allows us to of articular cartilage. Articular estimate in vivo tissue mechanics cartilage is the thin layer of con- in a non-invasive and subject- nective tissue covering the end of specific manner. The work in our bones in our joints: for the span group spans multiple dimensional of a lifetime, it provides stress scales, from basic experiments at redistribution and an extremely the tissue-level that enhance our low-friction contact. When the understanding of the mechanical tissue degenerates because of fatigue process, to applied experi- diseases such as osteoarthritis, ments at the whole-body level for it cannot perform its function the development of treatments properly and this results in pain, and interventions to improve limitation of mobility, and ulti- tissue quality and decrease injury mately a decrease in quality of life. risk. Understanding the relationship between the tissue structure and Salvatore Federico its function, remodelling and damage processes may shed light Continuum on the causes of the initiation Biomechanics Group of degeneration, and suggest Continuum Mechanics is the possible treatments to prevent study of matter at a length-scale at disease. which the existence of the atomic structure can be neglected, and Reed Ferber matter can be treated as continu- ous rather than discrete. Research Running Injury Clinic in our group is devoted to the I am a clinical biomechanist and mathematical foundations of my research is aimed at optimiz- Continuum Mechanics and its ap- ing rehabilitation and predicting plications to the Biomechanics of injuries. Overall, my group is en- Soft Tissue. In particular, we are gaged in two streams of research: interested in modelling soft tissue clinical gait analysis and wearable accounting for its structural ele- sensors. ments, i.e., collagen fibres, cells, My group has successfully es- non-fibrous extracellular matrix tablished an international and and fluid. Most phenomena of growing gait analysis research structural rearrangement in a network currently consisting biological tissue can be described of 15 researchers and over 100 under the umbrella of growth and clinical partners. Each centre remodelling. Structural damage is linked to the world’s largest is what can initiate injury and research database of biomechani- disease. cal gait and clinical data. They are A main theme is the modelling transforming the biomechanics Annual Report 2019 7
General Comments research community by openly In the area of muscle contrac- sharing data between labora- tion mechanisms, we showed tories, employing unique data unequivocally that cardiac muscle science analysis methods, and possesses residual force enhance- growing our research network. ment properties, a fact disputed Our wearable research is based previously in the literature. In the on three challenges: (1) wearable area of bone and joint biomechan- sensors generate a profound ics, we found that aerobic exercise amount of data that is largely and a fibre diet intervention can ignored; (2) the information prevent the onset of metabolic derived from these sensors is knee joint osteoarthritis, but only not placed within a contextual if the interventions are timed narrative; and (3) most sensors properly, otherwise they have are designed for activity monitor- no effect. Finally, in our applied ing and not for healthcare. To biomechanics research, we have address these challenges, I lead collected data that should provide the recently awarded NSERC a final answer to the question if Wearable Technology Research chiropractic spinal manipulation and Collaboration (We-TRAC) can damage vertebral arteries, training program. This program thereby initiating/causing strokes. builds on being selected in 2016 (by the Vice President – Research Art Kuo Dr. Ed McCauley) to lead the My laboratory studies the biome- Sensor Technology in Monitoring chanics, energetics, and neural Movement (STiMM) research pro- control of human movement. We gram supporting the University’s develop computational models of Eyes High “Engineering Solutions the human body dynamics, and for Health” research strategy. apply them to simulations and analyses of locomotion and upper Walter Herzog extremity reaching movements. For the past three years, much of We also perform experiments to our efforts were focused on hosting test model predictions of stability, the Conference of the International motion trajectories, and energy Society of Biomechanics (ISB), expenditure. Ongoing projects and the conference finally took include studies of human walking place between July 31st and Aug on uneven terrain, use of inertial 4th, 2019. With 2,200 partici- measurement units to record pants, the ISB conference was by locomotion in the real world, far the largest ever, and with the energetics of human reaching, and help of almost 100 volunteers, it modeling of neural central pattern was a scientific and social success. generators for locomotion. These 8 Human Performance Laboratory
General Comments projects are intended to reveal a deeper functional understand- basic mechanisms of locomotion ing as to why running in stiff shoes and other movements, with ap- can improve running performance plicability to neural rehabilita- by applying ultrasound imaging tion and diagnosis of movement and musculo-skeletal modelling. impairments. Furthermore, we have developed the teeter-totter concept to ex- Benno M. Nigg & Sandro plain the positive physiological Nigg effect of a curved midsole stiffness on running performance. Our group concentrates on topics Machine Learning and Human that are health and performance Locomotion: The objective is to related with special consider- better understand the underlying ations for footwear, apparel and principles of human locomotion equipment. This last year, we with the application of machine made significant progress in learning techniques. Specifically, our understanding of 1) the bio- our group has harvested extensive mechanical effects of altering inertial measurement unit data to midsole bending stiffness, 2) ap- automatically detect movements plying machine learning tools to of interest (e.g. sprint stride, cross identify the underlying principles over stride) in large continuous of human locomotion, and 3) data sets. Further algorithms have to better understand the inter- been created with the ability to coordination of segment motion classify the skill level of novice during human locomotion. and elite hockey players executing Midsole Bending Stiffness: The ef- these specific movement tasks. fect of modifying the longitudinal These accomplishments establish bending stiffness of a sports shoe the foundation to provide real has many biomechanical and time feedback to an individual’s physiological effects. Specifically, skating technique. we have studied the effects of Inter-Coordination of Segment increased longitudinal midsole Motion: Our group is investigating bending stiffness of sport shoes on how the movement of segments of running mechanics. The focus has the foot and the lower extremities been on how increased midsole are affected by changes in muscle bending stiffness can be used activity, integrity of ligaments or to redistribute lower limb joint various footwear characteristics work during running, and how using novel technologies such as this increased stiffness affects the dual fluoroscopy. The results de- amount and velocity of muscle termined using these techniques and muscle-tendon unit shorten- allow for a better interpretation ing. Our research aims to provide Annual Report 2019 9
General Comments of results than using traditional diabetic- and chemotherapy- motion analysis techniques. The induced peripheral neuropathy) results are further used to de- experience a decline in somato- termine the movement coupling sensory function that is associ- between lower limb segments ated with impairments in manual during running. dexterity and balance. Standard clinical tests of neuropathy are Ryan Peters arduous for clinicians and not well-controlled – vibration-emit- Integrative Sensorimotor ting wearable technologies offer a Neuroscience Laboratory promising alternative approach. Our laboratory investigates the These new wearable technologies neural basis of human movement will enable frequent and accurate using a variety of physiological, assessments of neurological func- behavioural, and computational tion to be performed outside of techniques in concert. There are the clinical setting, freeing-up both basic and applied streams valuable clinician time, and im- of research currently ongoing in proving the quality of patient care. the lab. Within the basic science stream, we study the complex Darren Stefanyshyn interaction between sensory and motor neurons during voluntary The general research interests movement. We specialize in mi- of our group focus on questions croneurography: the only method related to human locomotion, for directly recording the activity sport performance and sport of human somatosensory neurons injury biomechanics. Our re- (muscle spindles, Golgi tendon search extends to functional sport organs, skin and joint recep- equipment with a goal of tuning tors). We are currently focused the properties of the equipment on the functional properties of to specific athlete characteristics the muscle spindle’s fusimotor in order to maximize the athlete’s system, which remains poorly un- performance and minimize the derstood to-date, particularly in risk of injury. Performance re- humans. In the applied research search involves developing a basic stream, we are translating our understanding of the mechanics basic science into the develop- of human movement during vari- ment of new vibration-emitting ous locomotor and athletic move- wearable technologies for remote ments. The goal is to determine neurological diagnostics and the mechanical factors dictating monitoring. Both healthy older an athlete’s performance and how adults and individuals suffering performance can be improved by from neurological disorders (e.g., manipulating these particular 10 Human Performance Laboratory
General Comments factors. In 2019 we extended the Faculty of Kinesiology. We our industry work on identifying measured acute and chronic methods of matching sport equip- neuromuscular and cardiovas- ment to individual athletes. We cular adaptations in response to also continued to investigate the different exercise interventions. internal mechanisms that explain Our work concentrated on neu- successful athlete-equipment in- rophysiological adaptations that teractions and in 2019 expanded occur in the structure and func- our capabilities to study Achilles tion of the motor network (from tendon mechanics using ultra- the brain to the skeletal muscles) sound measurements. We also in response to different modes of began work with personalization upper and lower limb exercises. of footwear and insoles, working With application of non-invasive with 3D foot scans and 3D print- techniques such as transcranial ing of insoles and footwear. magnetic stimulation of the brain, Injury research involves identify- transmastoid and thoracic elec- ing potential injury factors such trical stimulation of the spinal as global loading characteristics cord as well as peripheral nerve associated with ankle and knee electrical stimulation of the skel- sport related injuries as well as etal muscles, we investigated the developing an understanding of relative contributions of central the role played by equipment. (i.e. the brain and spinal cord) and This past year we gained valuable peripheral nervous system(i.e. insight on the role of sport surface skeletal muscles) to the develop- characteristics as well as traction ment of neuromuscular fatigue of rugby boots on lower extremity in healthy individuals and people joint loading. with clinical conditions. We pub- lished our work in the flagship journals of our field including Exercise Physiology The Journal of Physiology, Brain and Nutrition in Sciences, Journal of Experimental Health and Sport Biology. Saied Jalal Aboodarda Exercise Neurophysiology Laboratory The research that we conducted in our lab in 2019 was the con- tinuation of the outstanding research environment that Prof. Guillaume Millet established in Annual Report 2019 11
General Comments Patricia K. Doyle-Baker environment for the athlete, is Applied Physiology and challenging for the researcher Prevention through because of the influence of chang- Lifestyle and Exercise ing weather conditions on testing days. Conversely, field testing can The Doyle-Baker lab continued also be exciting as often there is this past year with a focused an outcome that can be translated interest in hormonal levels and quickly to a target audience such hormone shifts that affect aero- as coaches. We look forward to bic performance and heart rate publishing our research related to variability, muscle and bone, the menstrual cycle phase influ- and perceived fatigue and stress ence on performance after a HIIT levels. We employed human and (high intensity training session) animal model research, and lab in cross-country skiers. and field work studies. To mea- Lastly, in collaboration with sure hormone levels (estrogen, groups in the HPL and University progesterone and testosterone) of Alberta we recently completed several biomarkers need to be a study investigating the influence employed so that the variability of eccentric training with and in hormonal shifts during each without bisphosphate drug in an menstrual cycle can be identified. older female rabbit model. The This means physically tracking long-term goal of this research the cycle length and using both program is to employ a sex spe- salivary and urine samples to cific complex training strategy determine when ovulation occurs. that will ensure bone strength is The population inclusive to those maintained across the life span. individuals taking exogenous hormones such as oral contracep- tives. Our collaborations with John Holash other exercise physiology lab Exercise Physiology groups in the HPL has very impor- Laboratory tantly contributed to the research In my new instructor’s role in the surrounding menstrual cycle faculty, I am currently working on phases and exercise performance. updating, developing, and modi- The Doyle-Baker lab also places fying courses, and instructional importance on field testing be- materials within the Exercise cause many athletes do not have Physiology group so that we can access to laboratory testing and leverage new technologies and gaps in field research in sports, instruments for course delivery. such as cross-country skiing, In this role I have participated are common in Canada. Field in a specialized focus group for testing, although in a familiar Video Technologies in Classroom 12 Human Performance Laboratory
General Comments (Yuja ) at the University of Martin MacInnis Calgary this spring and summer Exercise and Environmental of 2019, and I currently repre- Physiology Laboratory sent the faculty on the current “Learning Technologies Advisory We are an integrative physiology Committee”. I also hope over laboratory interested in under- the next few years to develop standing how humans respond a subgroup within the exercise to acute and chronic exercise physiology umbrella, with hopes and the extent to which these to integrate and develop the use responses are influenced by nutri- of state-of-the-art computer- tion, sex, and the environment. based methods for measuring, Our research group launched in recording, and analyzing these 2018, and our ongoing projects potentially very large data sets of investigate (i) adaptations in the physiological variables. The ulti- skeletal muscle, cardiovascular, mate goal of this subgroup will be and hematological systems to dif- to enhance the student experience ferent exercise training programs with opportunities for experience (ii) the mechanisms underpinning with: product development, rapid the plasticity of these physiologi- prototyping, machine learning, cal systems; (iii) the development and data processing, and poten- of non-invasive methods to assess tially some entrepreneurship skeletal muscle fitness; (iv) the opportunities that revolve around influence of oxygen availability leveraging digital technologies on aerobic metabolism, neuro- and scaling them. muscular fatigue, and exercise performance; and (v) the use of wearable technologies to improve exercise testing and prescription. We employ a wide breadth of techniques, ranging from the bio- chemical and molecular analysis of human tissue (e.g., blood and muscle) to whole-body measures of exercise metabolism, tolerance, and performance (e.g., pulmo- nary gas analysis and femoral nerve stimulation). The overall aim of our research program is to understand how molecular and physiological mechanisms regulate physiological systems in humans, with goals to trans- Annual Report 2019 13
General Comments late and apply this research to aerobic energy supply. Prior improve the health and fitness of heavy exercise performed as a individuals ranging from athletes warm-up results in acceleration to those with chronic disease and of the aerobic contributions to disability. subsequent exercise and smaller anaerobic requirements. A struc- Brian MacIntosh turally realistic computer model of a sarcomere has been created, Applied Muscle and the impact of myofilaments Physiology Group at different sarcomere lengths The central theme of research on calcium diffusion has been in my laboratory is the study evaluated. Our research group of force modulation in skeletal uses a number of approaches to muscle. This includes the study study the contractile properties of force-velocity, force-frequency of skeletal muscle including: (1) and force-length relationships, in vitro single intact or skinned and the interactions of these with fibers and fiber bundles; or (2) in and without prior activity. Prior situ whole muscle and intact hu- activity can be an acute modi- man subjects performing in vivo fier, as in potentiation or fatigue. with isolated muscle or muscle Alternatively, prior activity can group contractions or performing be a chronic modifier, as in train- whole body exercise. ing, illness or disuse atrophy. A new theory of muscle fatigue has Juan Murias been proposed which states that fatigue is a consequence of the Cardiovascular Exercise elegant regulation of excitation- Physiology Group contraction coupling in skeletal I am interested in determin- muscle to prevent depletion of ing the effectiveness of exercise adenosine triphosphate. Recent training programs for promoting work has evaluated the poten- health as well as for improving tial role of changes in calcium performance. The main goal of sensitivity at physiological tem- my research relates to the use of perature contributing to muscle exercise training interventions as potentiation and fatigue. We are “medicine” to prevent or alleviate continuing the work on warm-up the detrimental effects of aging and post-activation potentiation. and disease on cardiovascular Work on understanding the slow function, as well as to improv- component has revealed that ing performance. Although my it does not represent a rising laboratory examines both central energy cost of exercise, but a and peripheral cardiovascular slow switch from anaerobic to adaptations to exercise training, 14 Human Performance Laboratory
General Comments a current direction of my work is Nutrition, focusing on the vascular side of Metabolism and these adaptive responses. More Genetics specifically, I am interested in the role of the endothelium in the Raylene Reimer control and distribution of blood flow and the effects of endurance Our research focuses on under- training exercise in preventing or standing how nutrition and the alleviating the age-related reduc- bacteria that live in our intestine tion in endothelium-dependent (called gut microbiota) interact vasodilation, and the associated to affect our risk of developing limitation in O2 transport to the chronic diseases such as obesity, sites of metabolic need. type 2 diabetes and fatty liver dis- Some of the measures commonly ease. This year we examined how assessed in my laboratory in- exposure to antibiotics in early clude: Breath-by-breath VO2 life (mother during pregnancy or and near-infrared spectroscopy early infancy) increases obesity (NIRS) to estimate blood oxy- and risk and how diet can be used to deoxygenation within the area of lessen this risk. Specifically we NIRS “inspection”. The use of this are showing that prebiotic fiber, technique combined with mea- a unique type of dietary fiber surements of VO2 can provide an that increases healthy bacteria estimate of the matching of mus- in the intestine, when given at cle O2 delivery to O2 utilization. the same time as antibiotics can Additionally, Doppler Ultrasound reduce the risk of obesity. We is used to estimate blood flow, have also been examining how vascular conductance and flow to bring human infant formula mediated dilation responses at closer to the nutritional gold stan- rest and during exercise, and to dard of breastmilk. This work is obtain morphological measures examining how supplementing to derive the lumen-to-wall ratio early life diet with human milk in different arteries. oligosaccharides (which act like fiber in mother’s milk and feed the healthy bacteria in the gut) can improve gut microbiota profiles and lifelong metabolic health. We are also very involved in translating animal studies into human clinical studies. We are currently evaluating: (1) the effect of prebiotic fiber on liver health in patients with non-alcoholic fatty Annual Report 2019 15
General Comments liver disease; (2) the effect of pre- Carolyn Emery biotic fiber supplement on pain Sport Injury Prevention and function in individuals with Research Centre (SIPRC) knee osteoarthritis and obesity; and (3) how gut microbiota differ I am the Chair of the Sport Injury in youth with obsessive compul- Prevention Research Centre sive disorder compared to healthy (SIPRC), 1 of 11 International control youth. Ultimately our goal Olympic Committee Research is to design and evaluate new Centres for Injury Prevention of food ingredients and diets aimed Injury and Protection of Athlete at body weight management and Health (2019-2022). Evaluation optimal gut microbiota profiles. of prevention strategies to reduce the burden of injuries and their consequences in youth sport is Injury Prevention, the focus of my research pro- Sport Medicine and gram. Our group continues to Rehabilitation build on national body checking policy change in 11-12 year old Amanda Black ice hockey to demonstrate a 56% The injury prevention, clinical reduction in all injuries (includ- intervention, and implementa- ing concussions) in non-elite tion science research group is a 13-14 year old leagues following new group in the Sport Injury policy disallowing body checking Prevention Research Centre. (preventing 6386 injuries nation- Core projects focus on: 1) injury ally each year). My research team surveillance and epidemiology, evaluated a neuromuscular train- 2) evidence-based practice and ing (NMT) warm-up program knowledge translation, and 3) implementation in junior high theory-driven implementation, school physical education in a behaviour change and evalua- 3-year randomized controlled tion. Ongoing projects include trial (RCT), demonstrating a 46% examining the implementation of reduction in injury risk in girls. concussion guidelines, education Through a National Basketball and management protocols for Association General Electric part- sporting organizations and high nership grant, the SIPRC team is schools, examining the context contributing to a greater under- for implementation for injury standing of patellar and Achilles prevention initiatives, and injury tendinopathies in youth basket- surveillance in high school and ball players including workload university athletic populations. and other risk factors and in- forming prevention strategies. Canadian Institutes of Health 16 Human Performance Laboratory
General Comments Research funded Surveillance in anterior cruciate ligament (ACL) High Schools to Reduce Injuries techniques was published in and their Consequences in Youth the Journal of Bone and Joint Sport (SHRed Injuries) focuses Surgery and was one of the top 10 on the prevention of musculo- most read articles in 2019. This is skeletal injuries and their con- the largest randomized trial on sequences in multiple youth ACL surgery ever published with sports and communities (e.g., 330 patients and 95% follow-up indigenous). An RCT in young at 5 years. adults is underway to evalu- The International Hip Outcome ate an exercise intervention to Tool (iHOT) was primarily devel- prevent early osteoarthritis fol- oped at the SMC and as of 2019, lowing sport-related knee injury has been translated into five in youth. A National Football languages with more in the works League Scientific Advisory for 2020. This outcome measure Board funded program, SHRed has been used in clinical trial and Concussions, is a pan-Canadian studies worldwide to evaluate program of research aiming to in- young and active patients with form best practice in concussion hip-related disorders. Further prevention detection, diagnosis, partnerships continue with the prognosis, management and McCaig Institue in the area of rehabilitation across multiple bone density and x-ray evalua- youth sports. Through the Vi tion in patients with ACL injury Riddell Pediatric Rehabilitation and long-term outcomes of ACL Research Program, her team surgery are on-going. strives to inform evidence-based rehabilitation strategies and In 2019 the STABILITY-1, ACL adapted physical activity pro- surgical multi-centre trial, re- grams for children with cerebral ceived awards at the International palsy, joint injuries, juvenile idio- Society of Arthroscopy Kneed pathic arthritis, and concussion. Surgery and Sports Medicine conference. This clinical trial was established at Western Nick Mohtadi University in London, ON and My research activities at the included centres in England, University of Calgayr, Sport Belgium and multiple sites in Medicine Centre (SMC) involve: Canada. This trial is now the Osteoarthritis, knee injury, largest randomized trial ever shoulder research, sport injury conducted in the world with preventation and clinical trials. 626 patients. The SMC Acute In 2019 a randomized clinical Knee Injury Clinic contributed trial comparing three different 10-20% of the surgical patients Annual Report 2019 17
General Comments and are now working on the next health care costs related to sport ACL study, the STABILITY-2 trial. injuries. This has support from the CIHR and the NIH and will be recruiting Kathryn Schneider 1200 patients. Concussion Prevention, The Sport Medicine Centre contin- Detection and ues to provide healthcare services Rehabilitation Lab based on the research conducted in the area of knee and shoulder Our lab focuses on the prevention, injuries and sport concussion. detection and rehabilitation of concussion with a special interest in the role of the cervical spine and Kati Pasanen balance systems. We use clini- My research program is focused cal and technological tests that on research of sport injuries, evaluate multiple different areas including epidemiological, clinical, of sensory and motor function, biomechanical and experimental ultimately gaining insight into studies. Our ongoing studies fo- changes that may occur following cus on: 1) development of novel a concussion. Additionally, with methods for monitoring move- the use of technological tests ment patterns and training load alongside clinical tests we are by using wearable technology in gaining a better understanding youth soccer, 2) identification of of how to best evaluate various risk factors for lower extremity components of function. injuries in youth team sports, and Ongoing projects in the lab focus 3) development and evaluation of on: 1) the role of neuromuscu- neuromuscular training programs lar training and sensorimotor to decrease the risk of injuries training in the prevention of in youth team sports. We also concussion 2) changes that occur have four collaboration studies in measures of cervical spine, in Finland – four of them in team vestibular and sensory function sport and one in professional with growth and development 3) ballet (Principal investigator: K changes that occur in measures Pasanen). Knowledge generated of cervical spine, vestibular and from our research work and col- sensory function following a laboration could ultimately lead to concussion, 4) optimizing reha- better understanding of causes and bilitation techniques to enhance mechanisms of lower extremity recovery and inform clinical care injuries which could allow us to and 5) Evaluating implementa- develop current injury prevention tion of concussion protocols. Our strategies, promote lifelong sport program of clinical research in- participation, and lower the public volves collaboration with multiple 18 Human Performance Laboratory
General Comments clinicians and researchers across Our group is currently leading the University of Calgary and the exercise-based measures in other national and international the Pan-Canadian Surveillance in institutions, ultimately enabling High Schools to REDuce (SHRed) clinically meaningful questions to Concussions project. Additionally be evaluated and translated back we are actively collaborating with to the clinic. other Canadian institutions on objectively quantifying the extent Jonathan Smirl concussed athletes rest and exer- cise following concussions. We are Cerebrovascular Concussion excited to have our new lab space Research Laboratory operational early in 2020 and We are a newly established group will be adding numerous other in the Sport Injury Prevention physiologically informed projects Research Centre and the Human to our mandate throughout the Performance Laboratory. Our year. Through our integrative work is focused on understand- approach to concussion research ing the basis of the physiological and collaboration network, we and autonomic disruptions which aim to create new approaches and occur following concussion. We interventions which will enable us aim to use this knowledge base to objectively assess physiological to develop informed interven- disruptions following concussion tions (exercise, physiological and improve outcomes for indi- and pharmacological) which can viduals following this traumatic be used to aid in the recovery injury. process during both the acute and chronic symptom periods. Annual Report 2019 19
Public Engagement Presentations Bike 2019 Conference. Calgary Central Library. Calgary, Canada. May 8. Patricia K. Doyle-Baker — Bikes and Bike Share: What is the benefit of e-Bikes? The Bone Academy Mexico. Puerto Vallarta, Mexico. March. Brent Edwards — Biomechanics of atypical femoral fracture. Siksika Community. November. Amanda Black — Concussion Management Protocols: Recognition and Management. Counselling and Development Centre. York University. November 20. Amanda Black — Concussion Recognition, Accommodations, and Management. Chinook Rotary Club. Calgary, Canada. October 2,. Kathryn Schneider — Concussion: Who, What, Where, When and What’s Next? Seminar in Exercise Physiology. Saint-Etienne, France. July 4. Juan Murias— Exercise intensity prescription: How close (or how far) are we from getting it right? Seminar in Exercise Physiology. Verona, Italy. July 8. Juan Murias— Exercise intensity prescription: How close (or how far) are we from getting it right? Tips for Hips - Community Outreach. University of Calgary Sport Medicine Centre. Calgary, Canada. April. Preston Wiley — Hip Anatomy and Soft Tissue Injury. Calgary Youth Science Fair. Calgary, Canada. April 5. Kathryn Schneider — How Science Has Impacted My Life. Canadian Concussion Prevention Meeting, Sport Information Resource Canada (SIRC). Ottawa, Canada. June. Kathryn Schneider — Models of prevention (of concussion). Retirement Presentation, Faculty of Kinesiology, University of Calgary. Calgary, Canada. October 3. Brian MacIntosh — Reflections and illuminations: with a little help 20 Human Performance Laboratory
Public Engagement from my friends (students). University of Sao Paulo. Ribeirao Preto, Brazil. October 22. Walter Herzog — Reflections on muscle: how do muscles contract? Calgary Winter Club, Skating Banquet. Calgary, Canada. May 3. Patrician Doyle-Baker — Talk, Knowledge and Outcome: Communicating the value of sport. Academic Education Day in Rheumatology. Cumming School of Medicine, University of Calgary. Calgary, Canada. November. Reed Ferber — Using wearable sensor data to inform clinical care. Canadian Athletic Therapists’ Association Annual Meeting. Calgary, Canada. June. Reed Ferber — Wearable Technology in Injury Prevention and Rehabilitation. Canada West University Athletics Association (CWUAA) Medical Committee 2019 Meeting. Calgary, Canada. January. Reed Ferber — Wearable technology in injury prevention and rehabilitation. Seminar in Kinesiology. University of Saskatchewan. Saskatoon, Canada. October 9. Brian MacIntosh — Where you come from will determine what you see: a fresh look at the slow component of oxygen intake. Workshops, Panels, & Booths Cervical spine and vestibular considerations following sport-related concussion. — Kathryn Schneider Concussion symposium, World Sport Physiotherapy Congress 2019, Vancouver, Canada. October 3. Concussion Harmonization IMPlementation and Evaluation in Canada workshop. — Kathryn Schneider, Amanda Black National Sport Organizations. October 31 & December 2. Concussion Harmonization IMPlementation and Evaluation in Canada (CHAIMP) study. — Kathryn Schneider, Amanda Black Audience: National Sport Organization (NSO) stakeholders including health care professionals, administrators. Annual Report 2019 21
Public Engagement In collaboration with: Parachute and Own the Podium (OTP). October 31; Parachute and Coaching Association of Canada. December 2. Managing our healthy ‘selves’ is a leadership challenge. — Patricia K. Doyle-Baker Student and enrolment services professional day workshop. University of Calgary, Calgary, Canada. June 27. Models of prevention (of concussion). — Kathryn Schneider Canadian concussion prevention meeting. SIRC meeting, Ottawa, Canada. June 10. Neuromuscular Training. — Kati Pasanen Presentation and practical session at the 5th IOC Sport Medicine Diploma Program. Neuromuscular Warm-up Program. — Larissa Taddei, Carla van den Berg Workshops for soccer coaches for approximately 80 coaches from the Minor Soccer Association. November. Physical activity and aging. — Meghan McDonough, Juan Murias, Patricia K. Doyle-Baker, Graduate Students. Approximately 50 older adults and stakeholders from Calgary. public event hosted by the Aging PEEPS. May 16. Preventing and managing head injuries in sport – Rehabilitation after concussion: multidisciplinary approach. — Kathryn Schneider, Carolyn Emery Panel presentation. Preventing and managing head injuries in sport. Norwegian Sport Medicine. Lillehammer, Norwary. November 22. Primary prevention in youth sport: Time to get on with it! — Carolyn Emery Prevention of injury in youth sport webinar. Pediatric Research in Sports Medicine Society (PRiSM) and Canadian Athletic Therapists Association (CATA). May. Recent research using wearable sensor data. — Reed Ferber Video conference with Rothesay Netherwood School, New Brunswick. May. Shoulder check: The causes and treatment for non-arthritic shoulder 22 Human Performance Laboratory
Public Engagement pain. — Nicholas Mohtadi, Richard Boorman, Aaron Bois, Ryan Shields, Martin Zacharias Free public forum. September 23. SHRed concussions: Moving upstream to the prevention of sport-related concussion in youth. — Carolyn Emery Canadian Concussion Prevention Workshop. Sport Information Research Canada/ Sport Canada, Ottawa, Canada. June. Small group learning presentation on exercise performance and development in master’s athletes. — John Holash Winter snow camp, Foothills nordic ski club. November 17-18. The basic function of the heart. — David Montero Workshop for 25 students. Discovery Day of Health Sciences, Canadian Medical Hall of Fame. The role of an exercise specialist in chronic disease management. — Patricia K. Doyle-Baker Physician workshop, EIMC National Student Research & Medical Conference 2019. University of Calgary, Calgary, Canada. June 28. The stickiness factor: Do we have it. — Patricia K. Doyle-Baker Panel presentation, ActiveCITY Summit, Winsport, Calgary, Canada. September 18. Tips for hips: How to manage non-arthritic hip pain. — Nicholas Mohtadi, Preston Wiley, Alex Rezansoff, David Lindsay Free public forum. April 8. Wearable Technology Research And Collaboration (We-TRAC). — Reed Ferber Annual Workshop, Calgary, Canada. November. Media & Interviews 6000 fewer injuries when bodychecking pulled from some bantam hockey: study. — Carolyn Emery CBC News Calgary, David Bell. November 7. A weighty subject: How the obesity epidemic is taking a toll on our bones and joints. — Raylene Reimer UCalgary News, Nancy Whelan, McCaig Institute for Bone and Annual Report 2019 23
Public Engagement Joint Health. March 25. Are High Priced Shoes Worth the Cost? — Darren Stefanyshyn, Bill Wannop Are High Priced Shoes Worth the cost? Testing Adidas, Nike and Under Armour. CBC Marketplace. Jeremy McDonald, Tyana Grundig and Asha Tomlinson. November 2. Shoe Wars: High Cost vs. Low Cost. CBC Marketplace. Jeremy McDonald, Tyana Grundig and Asha Tomlinson. November 2. Ban on bodychecking in non-elite Bantam ice hockey significantly reduces injury. — Carolyn Emery UCalgary news, Stacy McGuire, Faculty of Kinesiology. November 12. Boxing deaths could have been prevented. — Ryan Peters Calgary Sun, Michael ‘Mr. Boxing YYC’ Short. August 12. Calgary researcher faces off against concussions in young athletes. — Carolyn Emery Calgary Journal, on-line, Bill Atwood. September 11. Carbon fibre plate tech: the Calgary connection. — Darren Stefanyshyn Canadian Running, Anne Francis. August 21. Citizen scientists with wearable tech needed for UCalgary project. — Reed Ferber UCalgary news. September 18. Here’s What Proper Running Form Actually Is and How Much You Should Care About. — Reed Ferber Self: Running, Amy Marturana Winderl. April 2. How do you eat to feed trillions? Food and the health of our gut microbiomes. — Raylene Reimer Explore UCalgary, Doug Ferguson. December 17. How does research make better policy? Public policy and the dance of democracy. — Kathryn Schneider Explore UCalgary, Jane Chamberlain. May 1,. In Conversation with Kathryn Schneider, Renowned Clinician Scientist. — Kathryn Schneider The Muse, Modeline Longjohn. April 10. 24 Human Performance Laboratory
Public Engagement Markin undergrad looks at link between exercise intensity and prevention of cardiovascular disease — Juan Murias UCalgary News, Stephanie Vahaaho, Markin USRP in Health and Wellness. April 1. Massive Open Online Course (MOOC). — Kathryn Schneider University of Calgary says “come one, come all” to free sports concussion course. The Canadian Press, Donna Spencer. February 4. Calgary Herald National Post Nanaimo News Battlefords Now PG Citizen University of Calgary making free sports concussion course available to anybody who is interested. Global News University of Calgary offers “groundbreaking” free online course on sports concussions. CBC News University of Calgary offers free course on concussions. The Star University to offer free concussion prevention course. 660 News, Derek Craddock. February 5. Concussion Training at U of C. Calgary Today with Joe McFarland. February 7. Massive Open Online Course on Concussion. CityTV, Josh Ritchie. February 4. Online course allows anyone, anywhere to learn about concussions. UCalgary News, Live on Instagram, University Relations Staff. June 10. Kinesiology researcher partners with Universite Laval on free concussion course. UCalgary News, Leanne Yohemas. February 4, 2019. MPowrx announces launch of BellyCrush - a new way to manage your weight. — Raylene Reimer Cision News. December 4. New study looks at injuries and concussions in minor hockey. — Carolyn Emery CBC News, The Homestretch. November. Annual Report 2019 25
Public Engagement Researchers gaining yards against concussions (CIHR). — Kathryn Schneider myFM radio. January 29, 2019. CKNW Global News Radio Vancouver. February 2. Riding a Lime e-Bike. — Patricia Doyle-Baker 770 Radio CHQR, Gord Gillies. May 28. Should You Do Single-Leg Cycling Drills? — Juan Murias Bicycling, Selene Yeager. November 8. UCalgary researcher passionate about this emerging sport, along with understanding ways to prevent injury in all sport. — Kati Pasanen UToday. May 30. Group Hosting, Tours & Events Bishop Grandin High School — March 18 (20 students), December 9 (20 students) 40 sport medicine students toured the University of Calgary and attended a lecture on injury prevention, concussion, and neuromuscular training warm-ups. Concussion and injury prevention research demonstrations and education — 12 visits throughout 2019 8 high schools (12 visits with 20-100 students per visit) hosted by the Sport Injury Prevention Centre. Heritage Youth Researchers Summer Program (HYRS) — August 19 34 students with the Heritage Youth Researchers Summer Program visited six stations presented by various groups in the HPL. XXVII Congress of the International Society ofBiomechanics (ISB2019) and the 43rd Annual Meeting of the American Society of Biomechanics (ASB2019) — July 31 - August 4 Over 2100 attendees, representing more than 40 countries. Nelson Mandela High School — January 9 (60 students), January 11 (60 students), October 22 (66 students) 186 sport medicine students toured the University of Calgary and attended a lecture on injury prevention, concussion and neuromuscular training warm-ups.. 26 Human Performance Laboratory
Public Engagement Operation Minerva — May 12 14 female junior high students visited stations and attended a lecture featuring female scientists in the HPL and faculty. Sanofi BioGenius — April 18 11 students visited 5 research demonstration stations, presented by various groups in the HPL. IBM STEM4Girls — August 14 28 students visited 5 stations, presented by various groups in the HPL Shad Valley Tour 2019 — July 15 64 stduents enrolled in the sport medicine program visited 9 stations, presented by various groups in the HPL St. Mary’s High School — June 11 35 stduents enrolled in the sport medicine program visited 6 stations, presented by various groups in the HPL Western Canada High School — November 25 30 sport medicine students toured the University of Calgary and attended a lecture on injury prevention, concussion, and neuromuscular training warm-ups. Annual Report 2019 27
Public Engagement Blog Posts Free MOOC on concussion at the University of Calgary. — Kathryn Schneider, Pierre Fremont British Journal of Sport Medicine (BJSM) Blog. July 24. Life is short: don’t take your health for granted. — Patricia K. Doyle-Baker. January 24. The wisdom of students: future health leaders. — Patricia K. Doyle-Baker. January 8. Public Health Matters: Three decades later my career is still sweet. — Patricia K. Doyle-Baker. August 21. Other Knowledge Translation Activities Concussion Management: A Toolkit for Physiotherapists. — Kathryn Schneider, L. Loranger, Codi Isaac, Catherine Ross, Carol Miller Physiotherapy Alberta College + Association. Revision of toolkit. May 2019. Discussing the AIM study (Adiposity, Influenza and Men). A common experience to the influenza vaccine: wouldn’t it be nice! — Patricia K. Doyle-Baker Open Access Government. May 15. Influenza vaccine response may be influenced by lifestyle factors in highly active young men. — Patricia K. Doyle-Baker, A Stewart Canadian Society for Exercise Physiology, Knowledge Translation communiqué. August 21. Keeping the message simple: Energy expenditure of restaurant servers. — Patricia K. Doyle-Baker Adjacent Government. February 7. 28 Human Performance Laboratory
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