Publications - LIMES-Institut
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LIMES - Publications
Life & Medical Sciences Institute
2020
Aguirre-Gamboa R, de Klein N, di Tommaso J, Claringbould A, van der Wijst MG, de Vries D, Brugge H,
Oelen R, Võsa U, Zorro MM, Chu X, Bakker OB, Borek Z, Ricaño-Ponce I, Deelen P, Xu CJ, Swertz M,
Jonkers I, Withoff S, Joosten I, Sanna S, Kumar V, Koenen HJPM, Joosten LAB, Netea MG, Wijmenga
C; BIOS Consortium, Franke L, Li Y. Deconvolution of bulk blood eQTL effects into immune cell
subpopulations. BMC Bioinformatics. 2020 Jun 12;21(1):243. doi: 10.1186/s12859-020-03576-5.
PMID: 32532224
Alam S, Piazzesi A, Abd El Fatah M, Raucamp M, van Echten-Deckert G. Neurodegeneration Caused
by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone
Acetylation. Cells. 2020 Sep 28;9(10):2189. doi: 10.3390/cells9102189. PMID: 32998447
Aleva FE, Tunjungputri RN, van der Vorm LN, Li Y, Heijdra YF, Oosting M, Smeekens SP, Jaeger M, Joosten
LAB, de Groot PG, Netea MG, van der Ven AJAM, de Mast Q. Platelet Integrin αIIbβ3 Activation is
Associated with 25-Hydroxyvitamin D Concentrations in Healthy Adults. Thromb Haemost. 2020
May;120(5):768-775. doi: 10.1055/s-0040-1709523. Epub 2020 May 5. PMID: 32369848
Ali N, Janssen AWM, Jaeger M, Van de Wijer L, van der Heijden W, Ter Horst R, Vart P, van Gool A, Joosten
LAB, Netea MG, Stienstra R, De Galan BE, Tack CJ. Limited impact of impaired awareness of
hypoglycaemia and severe hypoglycaemia on the inflammatory profile of people with type 1
diabetes. Diabetes Obes Metab. 2020 Dec;22(12):2427-2436. doi: 10.1111/dom.14172. Epub 2020
Sep 22. PMID: 33462962
Angelidou A, Conti MG, Diray-Arce J, Benn CS, Shann F, Netea MG, Liu M, Potluri LP, Sanchez-Schmitz G,
Husson R, Ozonoff A, Kampmann B, van Haren SD, Levy O. Licensed Bacille Calmette-Guérin (BCG)
formulations differ markedly in bacterial viability, RNA content and innate immune activation.
Vaccine. 2020 Feb 24;38(9):2229-2240. doi: 10.1016/j.vaccine.2019.11.060. Epub 2020 Jan 28.
PMID: 32005538
Arastehfar A, Carvalho A, Nguyen MH, Hedayati MT, Netea MG, Perlin DS, Hoenigl M. COVID-19-
Associated Candidiasis (CAC): An Underestimated Complication in the Absence of Immunological
Predispositions? J Fungi (Basel). 2020 Oct 8;6(4):211. doi: 10.3390/jof6040211. PMID: 33050019
Asawa Y, Yoshimori A, Bajorath J, Nakamura H. Prediction of an MMP-1 inhibitor activity cliff using
the SAR matrix approach and its experimental validation. Sci Rep. 2020 Sep 7;10(1):14710. doi:
10.1038/s41598-020-71696-2. PMID: 32895466
Balbach M, Hamzeh H, Jikeli JF, Brenker C, Schiffer C, Hansen JN, Neugebauer P, Trötschel C, Jovine L, Han
L, Florman HM, Kaupp UB, Strünker T, Wachten D. Molecular Mechanism Underlying the Action
of Zona-pellucida Glycoproteins on Mouse Sperm. Front Cell Dev Biol. 2020 Aug 31;8:572735. doi:
10.3389/fcell.2020.572735. eCollection 2020. PMID: 32984353
1Becker M, Schultze H, Bresniker K, Singhal S, Ulas T, Schultze JL. A novel computational architecture
for large-scale genomics. Nat Biotechnol. 2020 Nov;38(11):1239-1241. doi: 10.1038/s41587-020-
0699-5. PMID: 32999473
Bekkering S, Saner C, Riksen NP, Netea MG, Sabin MA, Saffery R, Stienstra R, Burgner DP. Trained Immunity:
Linking Obesity and Cardiovascular Disease across the Life-Course? Trends Endocrinol Metab. 2020
May;31(5):378-389. doi: 10.1016/j.tem.2020.01.008. Epub 2020 Feb 8. PMID: 32305098 Review.
Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-
Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt
B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey
N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan
YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R,
Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J,
Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta
C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P; HCA Lung Biological
Network; Deutsche COVID-19 Omics Initiative (DeCOI). Longitudinal Multi-omics Analyses Identify
Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
Immunity. 2020 Dec 15;53(6):1296-1314.e9. doi: 10.1016/j.immuni.2020.11.017. Epub 2020 Nov
26. PMID: 33296687
Bethlehem L, van Echten-Deckert G. Ectoines as novel anti-inflammatory and tissue protective lead
compounds with special focus on inflammatory bowel disease and lung inflammation. Pharmacol
Res. 2021 Feb;164:105389. doi: 10.1016/j.phrs.2020.105389. Epub 2020 Dec 19. PMID: 33352226
Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner
L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C,
Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL. Publisher Correction:
Tumor-necrosis factor impairs CD4+ T cell-mediated immunological control in chronic viral
infection. Nat Immunol. 2020 Sep;21(9):1135. doi: 10.1038/s41590-020-0749-7. PMID: 32620862
Bianco E, Laval G, Font-Porterias N, García-Fernández C, Dobon B, Sabido-Vera R, Sukarova Stefanovska E,
Kučinskas V, Makukh H, Pamjav H, Quintana-Murci L, Netea MG, Bertranpetit J, Calafell F, Comas D.
Recent Common Origin, Reduced Population Size, and Marked Admixture Have Shaped European
Roma Genomes. Mol Biol Evol. 2020 Nov 1;37(11):3175-3187. doi: 10.1093/molbev/msaa156.
PMID: 32589725
Blaschke T, Feldmann C, Bajorath J. Prediction of Promiscuity Cliffs Using Machine Learning. Mol
Inform. 2021 Jan;40(1):e2000196. doi: 10.1002/minf.202000196. Epub 2020 Sep 29. PMID: 32881355
Blaschke T, Engkvist O, Bajorath J, Chen H. Memory-assisted reinforcement learning for diverse
molecular de novo design. J Cheminform. 2020 Nov 10;12(1):68. doi: 10.1186/s13321-020-00473-
0. PMID: 33292554
Böhme J, Martinez N, Li S, Lee A, Marzuki M, Tizazu AM, Ackart D, Frenkel JH, Todd A, Lachmandas E, Lum
J, Shihui F, Ng TP, Lee B, Larbi A, Netea MG, Basaraba R, van Crevel R, Newell E, Kornfeld H, Singhal
A. Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic
circuits. Nat Commun. 2020 Oct 16;11(1):5225. doi: 10.1038/s41467-020-19095-z. PMID: 33067434
Bonaguro L, Köhne M, Schmidleithner L, Schulte-Schrepping J, Warnat-Herresthal S, Horne A, Kern
P, Günther P, Ter Horst R, Jaeger M, Rahmouni S, Georges M, Falk CS, Li Y, Mass E, Beyer M, Joosten
LAB, Netea MG, Ulas T, Schultze JL, Aschenbrenner AC. CRELD1 modulates homeostasis of the
immune system in mice and humans. Nat Immunol. 2020 Dec;21(12):1517-1527. doi: 10.1038/
s41590-020-00811-2. Epub 2020 Nov 9. PMID: 33169013
2Bonanni D, Lolli ML, Bajorath J. Computational Method for Structure-Based Analysis of SAR Transfer.
J Med Chem. 2020 Feb 13;63(3):1388-1396. doi: 10.1021/acs.jmedchem.9b01931. Epub 2020 Jan
15. PMID: 31939664
Breiden B, Sandhoff K. Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal
Disease. Int J Mol Sci. 2020 Apr 7;21(7):2566. doi: 10.3390/ijms21072566. PMID: 32272755
Brouwer MAE, van de Schoor FR, Vrijmoeth HD, Netea MG, Joosten LAB. A joint effort: The interplay
between the innate and the adaptive immune system in Lyme arthritis. Immunol Rev. 2020
Mar;294(1):63-79. doi: 10.1111/imr.12837. Epub 2020 Jan 13. PMID: 31930745
Brouwer MAE, Jones-Warner W, Rahman S, Kerstholt M, Ferreira AV, Oosting M, Hooiveld GJ, Netea MG,
Joosten LAB. B. burgdorferi sensu lato-induced inhibition of antigen presentation is mediated by
RIP1 signaling resulting in impaired functional T cell responses towards Candida albicans. Ticks
Tick Borne Dis. 2021 Mar;12(2):101611. doi: 10.1016/j.ttbdis.2020.101611. Epub 2020 Nov 23.
PMID: 33360386
Bruno M, Kersten S, Bain JM, Jaeger M, Rosati D, Kruppa MD, Lowman DW, Rice PJ, Graves B, Ma Z, Jiao YN,
Chowdhary A, Renieris G, van de Veerdonk FL, Kullberg BJ, Giamarellos-Bourboulis EJ, Hoischen A,
Gow NAR, Brown AJP, Meis JF, Williams DL, Netea MG. Transcriptional and functional insights into
the host immune response against the emerging fungal pathogen Candida auris. Nat Microbiol.
2020 Dec;5(12):1516-1531. doi: 10.1038/s41564-020-0780-3. Epub 2020 Aug 24. PMID: 32839538
Bruno M, Zweijpfenning SMH, Verhoeven J, Boeree MJ, Netea MG, van de Veerdonk FL, van Ingen J,
Hoefsloot W. Subtle immunodeficiencies in nodular-bronchiectatic Mycobacterium avium
complex lung disease. ERJ Open Res. 2020 Oct 19;6(4):00548-2020. doi: 10.1183/23120541.00548-
2020. eCollection 2020 Oct. PMID: 33123562
Bruno M, Dewi IMW, Matzaraki V, Ter Horst R, Pekmezovic M, Rösler B, Groh L, Röring RJ, Kumar V, Li Y,
Carvalho A, Netea MG, Latgé JP, Gresnigt MS, van de Veerdonk FL. Comparative host transcriptome
in response to pathogenic fungi identifies common and species-specific transcriptional antifungal
host response pathways. Comput Struct Biotechnol J. 2020 Dec 26;19:647-663. doi: 10.1016/j.
csbj.2020.12.036. eCollection 2021. PMID: 33510868
Bülow MH, Parsons BD, Di Cara F. The Drosophila melanogaster as Genetic Model System to Dissect the
Mechanisms of Disease that Lead to Neurodegeneration in Adrenoleukodystrophy. Adv Exp Med
Biol. 2020;1299:145-159. doi: 10.1007/978-3-030-60204-8_11. PMID: 33417213
Bulut O, Kilic G, Domínguez-Andrés J, Netea MG. Overcoming immune dysfunction in the elderly:
trained immunity as a novel approach. Int Immunol. 2020 Nov 23;32(12):741-753. doi: 10.1093/
intimm/dxaa052. PMID: 32766848
Burgdorf S, Porubsky S, Marx A, Popovic ZV. Cancer Acidity and Hypertonicity Contribute to Dysfunction
of Tumor-Associated Dendritic Cells: Potential Impact on Antigen Cross-Presentation Machinery
Cancers (Basel). 2020 Aug 24;12(9):2403. doi: 10.3390/cancers12092403. PMID: 32847079
Cabanillas B, Weighardt H, Izquierdo E, Förster I, Novak N. IgE reactivity against herpes simplex virus 1
in patients with atopic dermatitis complicated by eczema herpeticum. Allergy. 2020 Jan;75(1):226-
229. doi: 10.1111/all.13986. Epub 2019 Oct 2. PMID: 31315153
Chen L, Collij V, Jaeger M, van den Munckhof ICL, Vich Vila A, Kurilshikov A, Gacesa R, Sinha T, Oosting M,
Joosten LAB, Rutten JHW, Riksen NP, Xavier RJ, Kuipers F, Wijmenga C, Zhernakova A, Netea MG,
Weersma RK, Fu J. Gut microbial co-abundance networks show specificity in inflammatory bowel
disease and obesity. Nat Commun. 2020 Aug 11;11(1):4018. doi: 10.1038/s41467-020-17840-y.
PMID: 32782301
3Chen L, van den Munckhof ICL, Schraa K, Ter Horst R, Koehorst M, van Faassen M, van der Ley C, Doestzada
M, Zhernakova DV, Kurilshikov A, Bloks VW, Groen AK; Human Functional Genomics Project, Riksen
NP, Rutten JHW, Joosten LAB, Wijmenga C, Zhernakova A, Netea MG, Fu J, Kuipers F. Genetic and
Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver
Fat Content. Cell Rep. 2020 Oct 6;33(1):108212. doi: 10.1016/j.celrep.2020.108212. PMID: 33027657
Childers DS, Avelar GM, Bain JM, Pradhan A, Larcombe DE, Netea MG, Erwig LP, Gow NAR, Brown
AJP. Epitope Shaving Promotes Fungal Immune Evasion. mBio. 2020 Jul 7;11(4):e00984-20. doi:
10.1128/mBio.00984-20. PMID: 32636248
Cianni L, Lemke C, Gilberg E, Feldmann C, Rosini F, Rocho FDR, Ribeiro JFR, Tezuka DY, Lopes CD, de
Albuquerque S, Bajorath J, Laufer S, Leitão A, Gütschow M, Montanari CA. Mapping the S1 and S1’
subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents. PLoS
Negl Trop Dis. 2020 Mar 12;14(3):e0007755. doi: 10.1371/journal.pntd.0007755. eCollection 2020
Mar. PMID: 32163418
Ciarlo E, Heinonen T, Théroude C, Asgari F, Le Roy D, Netea MG, Roger T. Trained Immunity Confers
Broad-Spectrum Protection Against Bacterial Infections. J Infect Dis. 2020 Nov 9;222(11):1869-
1881. doi: 10.1093/infdis/jiz692. PMID: 31889191
Cirovic B, de Bree LCJ, Groh L, Blok BA, Chan J, van der Velden WJFM, Bremmers MEJ, van Crevel R,
Händler K, Picelli S, Schulte-Schrepping J, Klee K, Oosting M, Koeken VACM, van Ingen J, Li Y, Benn
CS, Schultze JL, Joosten LAB, Curtis N, Netea MG, Schlitzer A. BCG Vaccination in Humans Elicits
Trained Immunity via the Hematopoietic Progenitor Compartment. Cell Host Microbe. 2020 Aug
12;28(2):322-334.e5. doi: 10.1016/j.chom.2020.05.014. Epub 2020 Jun 15. PMID: 32544459
Commichau FM, Anstatt J, Krappmann S, Stegmann E, Banhart S, Papenfort K, Brunke S, Hube B, Bramkamp
M, Herbert M, Sander J, Mueller JW, Wagner M, Daus ML. Journal Club. Biospektrum (Heidelb).
2020;26(3):280-286. doi: 10.1007/s12268-020-1383-5. Epub 2020 May 14. PMID: 32834536
D’Avanzo F, Rigon L, Zanetti A, Tomanin R. Mucopolysaccharidosis Type II: One Hundred Years of Research,
Diagnosis, and Treatment. Int J Mol Sci. 2020 Feb 13;21(4):1258. doi: 10.3390/ijms21041258. PMID:
32070051
de Bree LCJ, Mourits VP, Koeken VA, Moorlag SJ, Janssen R, Folkman L, Barreca D, Krausgruber T, Fife-
Gernedl V, Novakovic B, Arts RJ, Dijkstra H, Lemmers H, Bock C, Joosten LA, van Crevel R, Benn CS,
Netea MG. Circadian rhythm influences induction of trained immunity by BCG vaccination. J Clin
Invest. 2020 Oct 1;130(10):5603-5617. doi: 10.1172/JCI133934. PMID: 32692732
De Domenico E, Bonaguro L, Schulte-Schrepping J, Becker M, Händler K, Schultze JL. Optimized
workflow for single-cell transcriptomics on infectious diseases including COVID-19. STAR Protoc.
2020 Dec 16;1(3):100233. doi: 10.1016/j.xpro.2020.100233. eCollection 2020 Dec 18. PMID:
33377120
de Groot PF, Nikolic T, Imangaliyev S, Bekkering S, Duinkerken G, Keij FM, Herrema H, Winkelmeijer M,
Kroon J, Levin E, Hutten B, Kemper EM, Simsek S, Levels JHM, van Hoorn FA, Bindraban R, Berkvens
A, Dallinga-Thie GM, Davids M, Holleman F, Hoekstra JBL, Stroes ESG, Netea M, van Raalte DH,
Roep BO, Nieuwdorp M. Oral butyrate does not affect innate immunity and islet autoimmunity in
individuals with longstanding type 1 diabetes: a randomised controlled trial. Diabetologia. 2020
Mar;63(3):597-610. doi: 10.1007/s00125-019-05073-8. Epub 2020 Jan 8. PMID: 31915895
Di Dalmazi G, Altieri B, Scholz C, Sbiera S, Luconi M, Waldman J, Kastelan D, Ceccato F, Chiodini I,
Arnaldi G, Riester A, Osswald A, Beuschlein F, Sauer S, Fassnacht M, Appenzeller S, Ronchi CL. RNA
Sequencing and Somatic Mutation Status of Adrenocortical Tumors: Novel Pathogenetic Insights.
J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa616. doi: 10.1210/clinem/dgaa616. PMID:
32875319
4Diehl KL, Vorac J, Hofmann K, Meiser P, Unterweger I, Kuerschner L, Weighardt H, Förster I, Thiele
C. Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet
and Inflammation. Cells. 2020 Oct 8;9(10):2258. doi: 10.3390/cells9102258. PMID: 33050035
Dimopoulos G, de Mast Q, Markou N, Theodorakopoulou M, Komnos A, Mouktaroudi M, Netea MG,
Spyridopoulos T, Verheggen RJ, Hoogerwerf J, Lachana A, van de Veerdonk FL, Giamarellos-
Bourboulis EJ. Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary
Hemophagocytic Lymphohistiocytosis. Cell Host Microbe. 2020 Jul 8;28(1):117-123.e1. doi:
10.1016/j.chom.2020.05.007. Epub 2020 May 14. PMID: 32411313
Dobon B, Ter Horst R, Laayouni H, Mondal M, Bianco E, Comas D, Ioana M, Bosch E, Bertranpetit J, Netea
MG. The shaping of immunological responses through natural selection after the Roma Diaspora.
Sci Rep. 2020 Sep 30;10(1):16134. doi: 10.1038/s41598-020-73182-1. PMID: 32999407
Dogbevia G, Grasshoff H, Othman A, Penno A, Schwaninger M. Brain endothelial specific gene therapy
improves experimental Sandhoff disease. J Cereb Blood Flow Metab. 2020 Jun;40(6):1338-1350.
doi: 10.1177/0271678X19865917. Epub 2019 Jul 29. PMID: 31357902
Domínguez-Andrés J, Fanucchi S, Joosten LAB, Mhlanga MM, Netea MG. Advances in understanding
molecular regulation of innate immune memory. Curr Opin Cell Biol. 2020 Apr;63:68-75. doi:
10.1016/j.ceb.2019.12.006. Epub 2020 Jan 25. PMID: 31991317
Domínguez-Andrés J, Eleveld M, Renieris G, Boltje TJ, Mesman RJ, van Niftrik L, Moons SJ, Rettberg P, van
der Meer JWM, Giamarellos-Bourboulis EJ, Op den Camp HJM, de Jonge MI, Netea MG. Growth on
Carbohydrates from Carbonaceous Meteorites Alters the Immunogenicity of Environment-Derived
Bacterial Pathogens. Astrobiology. 2020 Nov;20(11):1353-1362. doi: 10.1089/ast.2019.2173. Epub
2020 May 8. PMID: 32391711
Domínguez-Andrés J, Netea MG. The specifics of innate immune memory. Science. 2020 Jun
5;368(6495):1052-1053. doi: 10.1126/science.abc2660. PMID: 32499424
Domínguez-Andrés J, van Crevel R, Divangahi M, Netea MG. Designing the Next Generation of Vaccines:
Relevance for Future Pandemics. mBio. 2020 Dec 22;11(6):e02616-20. doi: 10.1128/mBio.02616-20.
PMID: 33443120
Dos Santos JC, Leite Quixabeira VB, Teodoro Silva MV, Damen MSMA, Schraa K, Jaeger M, Oosting M,
Keating ST, Dorta ML, Alves Pinto S, Bugalho Duarte F, de Araújo Pereira LI, Netea MG, Ribeiro-
Dias F, Joosten LAB. Genetic variation in Interleukin-32 influence the immune response against
New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis. PLoS
Negl Trop Dis. 2020 Feb 5;14(2):e0008029. doi: 10.1371/journal.pntd.0008029. eCollection 2020
Feb. PMID: 32023240
Drabik A, Ner-Kluza J, Hartman K, Mayer G, Silberring J. Changes in Protein Glycosylation as a Result
of Aptamer Interactions with Cancer Cells. Proteomics Clin Appl. 2020 Jan;14(1):e1800186. doi:
10.1002/prca.201800186. Epub 2019 Nov 4. PMID: 31550741
Einwächter H, Heiseke A, Schlitzer A, Gasteiger G, Adler H, Voehringer D, Manz MG, Ruzsics Z, Dölken
L, Koszinowski UH, Sparwasser T, Reindl W, Jordan S. The Innate Immune Response to Infection
Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment. Front
Immunol. 2020 Jul 31;11:1627. doi: 10.3389/fimmu.2020.01627. eCollection 2020. PMID: 32849551
Fanucchi S, Domínguez-Andrés J, Joosten LAB, Netea MG, Mhlanga MM. The Intersection of Epigenetics
and Metabolism in Trained Immunity. Immunity. 2021 Jan 12;54(1):32-43. doi: 10.1016/j.
immuni.2020.10.011. Epub 2020 Nov 20. PMID: 33220235
Feldmann C, Bajorath J. Biological Activity Profiles of Multitarget Ligands from X-ray Structures.
Molecules. 2020 Feb 12;25(4):794. doi: 10.3390/molecules25040794. PMID: 32059498
5Feldmann C, Bajorath J. X-ray Structure-Based Chemoinformatic Analysis Identifies Promiscuous
Ligands Binding to Proteins from Different Classes with Varying Shapes. Int J Mol Sci. 2020 May
27;21(11):3782. doi: 10.3390/ijms21113782. PMID: 32471121
Feldmann C, Yonchev D, Stumpfe D, Bajorath J. Systematic Data Analysis and Diagnostic Machine
Learning Reveal Differences between Compounds with Single- and Multitarget Activity. Mol
Pharm. 2020 Dec 7;17(12):4652-4666. doi: 10.1021/acs.molpharmaceut.0c00901. Epub 2020 Nov
5. PMID: 33151084
Feldmann C, Yonchev D, Bajorath J. Analysis of Biological Screening Compounds with Single- or
Multi-Target Activity via Diagnostic Machine Learning. Biomolecules. 2020 Nov 27;10(12):1605.
doi: 10.3390/biom10121605. PMID: 33260876 Free PMC article.
Ferreira Castro A, Baltruschat L, Stürner T, Bahrami A, Jedlicka P, Tavosanis G, Cuntz H. Achieving
functional neuronal dendrite structure through sequential stochastic growth and retraction. Elife.
2020 Nov 26;9:e60920. doi: 10.7554/eLife.60920. PMID: 33241995
Ferreira AV, Domiguéz-Andrés J, Netea MG. The Role of Cell Metabolism in Innate Immune Memory. J
Innate Immun. 2020 Dec 30:1-9. doi: 10.1159/000512280. Online ahead of print. PMID: 33378755
Finke J, Mikuličić S, Loster AL, Gawlitza A, Florin L, Lang T. Anatomy of a viral entry platform differentially
functionalized by integrins α3 and α6. Sci Rep. 2020 Mar 24;10(1):5356. doi: 10.1038/s41598-020-
62202-9. PMID: 32210347
Finke J, Hitschler L, Boller K, Florin L, Lang T. HPV caught in the tetraspanin web? Med Microbiol
Immunol. 2020 Aug;209(4):447-459. doi: 10.1007/s00430-020-00683-1. Epub 2020 Jun 13. PMID:
32535702
Fischer-Riepe L, Daber N, Schulte-Schrepping J, Véras De Carvalho BC, Russo A, Pohlen M, Fischer J,
Chasan AI, Wolf M, Ulas T, Glander S, Schulz C, Skryabin B, Wollbrink Dipl-Ing A, Steingraeber N,
Stremmel C, Koehle M, Gärtner F, Vettorazzi S, Holzinger D, Gross J, Rosenbauer F, Stoll M, Niemann
S, Tuckermann J, Schultze JL, Roth J, Barczyk-Kahlert K. CD163 expression defines specific, IRF8-
dependent, immune-modulatory macrophages in the bone marrow. J Allergy Clin Immunol. 2020
Nov;146(5):1137-1151. doi: 10.1016/j.jaci.2020.02.034. Epub 2020 Mar 19. PMID: 32199911
García-Fernández C, Font-Porterias N, Kučinskas V, Sukarova-Stefanovska E, Pamjav H, Makukh H, Dobon
B, Bertranpetit J, Netea MG, Calafell F, Comas D. Sex-biased patterns shaped the genetic history of
Roma. Sci Rep. 2020 Sep 2;10(1):14464. doi: 10.1038/s41598-020-71066-y. PMID: 32879340
García-Fernández C, Font-Porterias N, Kučinskas V, Sukarova-Stefanovska E, Pamjav H, Makukh H, Dobon
B, Bertranpetit J, Netea MG, Calafell F, Comas D. Author Correction: Sex-biased patterns shaped
the genetic history of Roma. Sci Rep. 2020 Oct 20;10(1):18142. doi: 10.1038/s41598-020-75277-1.
PMID: 33077820
Genzel L, Adan R, Berns A, van den Beucken JJJP, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R,
Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, van Dam AM, Deen PMT, van Dijk KW, Eggen BJL,
Elgersma Y, Erdogan I, Englitz B, Fentener van Vlissingen JM, la Fleur S, Fouchier R, Fitzsimons CP,
Frieling W, Haagmans B, Heesters BA, Henckens MJAG, Herfst S, Hol E, van den Hove D, de Jonge
MI, Jonkers J, Joosten LAB, Kalsbeek A, Kamermans M, Kampinga HH, Kas MJ, Keijer JA, Kersten
S, Kiliaan AJ, Kooij TWA, Kooijman S, Koopman WJH, Korosi A, Krugers HJ, Kuiken T, Kushner SA,
Langermans JAM, Lesscher HMB, Lucassen PJ, Lutgens E, Netea MG, Noldus LPJJ, van der Meer
JWM, Meye FJ, Mul JD, van Oers K, Olivier JDA, Pasterkamp RJ, Philippens IHCHM, Prickaerts J, Pollux
BJA, Rensen PCN, van Rheenen J, van Rij RP, Ritsma L, Rockx BHG, Roozendaal B, van Schothorst
EM, Stittelaar K, Stockhofe N, Swaab DF, de Swart RL, Vanderschuren LJMJ, de Vries TJ, de Vrij F,
van Wezel R, Wierenga CJ, Wiesmann M, Willuhn I, de Zeeuw CI, Homberg JR. How the COVID-19
pandemic highlights the necessity of animal research. Curr Biol. 2020 Sep 21;30(18):R1014-R1018.
doi: 10.1016/j.cub.2020.08.030. Epub 2020 Aug 10. PMID: 32961149
6Giamarellos-Bourboulis EJ, Tsilika M, Moorlag S, Antonakos N, Kotsaki A, Domínguez-Andrés J, Kyriazo-
poulou E, Gkavogianni T, Adami ME, Damoraki G, Koufargyris P, Karageorgos A, Bolanou A, Koenen
H, van Crevel R, Droggiti DI, Renieris G, Papadopoulos A, Netea MG. Activate: Randomized Clinical
Trial of BCG Vaccination against Infection in the Elderly. Cell. 2020 Sep 1. pii: S0092-8674(20)31139-
9. doi: 10.1016/j.cell.2020.08.051. [Epub ahead of print] PMID: 32941801
Giamarellos-Bourboulis EJ, Netea MG, Rovina N, Akinosoglou K, Antoniadou A, Antonakos N, Damoraki
G, Gkavogianni T, Adami ME, Katsaounou P, Ntaganou M, Kyriakopoulou M, Dimopoulos G, Kout-
sodimitropoulos I, Velissaris D, Koufargyris P, Karageorgos A, Katrini K, Lekakis V, Lupse M, Kotsaki
A, Renieris G, Theodoulou D, Panou V, Koukaki E, Koulouris N, Gogos C, Koutsoukou A. Complex Im-
mune Dysregulation in COVID-19 Patients with Severe Respiratory Failure. Cell Host Microbe. 2020
Jun 10;27(6):992-1000.e3. doi: 10.1016/j.chom.2020.04.009. Epub 2020 Apr 21. PMID: 32320677
Gonçalves SM, Duarte-Oliveira C, Campos CF, Aimanianda V, Ter Horst R, Leite L, Mercier T, Pereira P,
Fernández-García M, Antunes D, Rodrigues CS, Barbosa-Matos C, Gaifem J, Mesquita I, Marques A,
Osório NS, Torrado E, Rodrigues F, Costa S, Joosten LA, Lagrou K, Maertens J, Lacerda JF, Campos
A Jr, Brown GD, Brakhage AA, Barbas C, Silvestre R, van de Veerdonk FL, Chamilos G, Netea MG,
Latgé JP, Cunha C, Carvalho A. Phagosomal removal of fungal melanin reprograms macrophage
metabolism to promote antifungal immunity. Nat Commun. 2020 May 8;11(1):2282. doi: 10.1038/
s41467-020-16120-z. PMID: 32385235
González-Medina M, Miljković F, Haase GS, Drueckes P, Trappe J, Laufer S, Bajorath J. Promiscuity
analysis of a kinase panel screen with designated p38 alpha inhibitors. Eur J Med Chem. 2020 Feb
1;187:112004. doi: 10.1016/j.ejmech.2019.112004. Epub 2019 Dec 20. PMID: 31881458
Grondman I, Pirvu A, Riza A, Ioana M, Netea MG. Biomarkers of inflammation and the etiology of sepsis.
Biochem Soc Trans. 2020 Feb 28;48(1):1-14. doi: 10.1042/BST20190029. PMID: 32049312
Gutierrez E, Lütjohann D, Kerksiek A, Fabiano M, Oikawa N, Kuerschner L, Thiele C, Walter J. Importance
of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism. Life Sci Alliance.
2020 Apr 30;3(6):e201900521. doi: 10.26508/lsa.201900521. Print 2020 Jun. PMID: 32354700
Hagen-Euteneuer N, Alam S, Rindsfuesser H, Meyer Zu Heringdorf D, van Echten-Deckert G.
S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic
capacity. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Aug;1865(8):158708. doi: 10.1016/j.
bbalip.2020.158708. Epub 2020 Apr 10. PMID: 32283310
Hamedani NS, Müller J, Tolle F, Rühl H, Pezeshkpoor B, Liphardt K, Oldenburg J, Mayer G, Pötzsch B.
Selective Modulation of the Protease Activated Protein C Using Exosite Inhibiting Aptamers.
Nucleic Acid Ther. 2020 Oct;30(5):276-288. doi: 10.1089/nat.2020.0844. Epub 2020 Jun 2. PMID:
32486960
Hoersting AK, Schmucker D. Axonal branch patterning and neuronal shape diversity: roles in
developmental circuit assembly: Axonal branch patterning and neuronal shape diversity in
developmental circuit assembly. Curr Opin Neurobiol. 2020 Nov 21;66:158-165. doi: 10.1016/j.
conb.2020.10.019. Online ahead of print. PMID: 33232861
Holz LE, Chua YC, de Menezes MN, Anderson RJ, Draper SL, Compton BJ, Chan STS, Mathew J, Li
J, Kedzierski L, Wang Z, Beattie L, Enders MH, Ghilas S, May R, Steiner TM, Lange J, Fernandez-
Ruiz D, Valencia-Hernandez AM, Osmond TL, Farrand KJ, Seneviratna R, Almeida CF, Tullett KM,
Bertolino P, Bowen DG, Cozijnsen A, Mollard V, McFadden GI, Caminschi I, Lahoud MH, Kedzierska
K, Turner SJ, Godfrey DI, Hermans IF, Painter GF, Heath WR. Glycolipid-peptide vaccination induces
liver-resident memory CD8+ T cells that protect against rodent malaria. Sci Immunol. 2020 Jun
26;5(48):eaaz8035. doi: 10.1126/sciimmunol.aaz8035. PMID: 32591409
7Hornung T, O’Neill HA, Logie SC, Fowler KM, Duncan JE, Rosenow M, Bondre AS, Tinder T, Maher V,
Zarkovic J, Zhong Z, Richards MN, Wei X, Miglarese MR, Mayer G, Famulok M, Spetzler D. ADAPT
identifies an ESCRT complex composition that discriminates VCaP from LNCaP prostate cancer
cell exosomes. Nucleic Acids Res. 2020 May 7;48(8):4013-4027. doi: 10.1093/nar/gkaa034. PMID:
31989173
Hu H, Bajorath J. Exploring structure-promiscuity relationships using dual-site promiscuity cliffs and
corresponding single-site analogs. Bioorg Med Chem. 2020 Jan 1;28(1):115238. doi: 10.1016/j.
bmc.2019.115238. Epub 2019 Nov 30. PMID: 31818631
Hu H, Bajorath J. Systematic Exploration of Activity Cliffs Containing Privileged Substructures. Mol
Pharm. 2020 Mar 2;17(3):979-989. doi: 10.1021/acs.molpharmaceut.9b01236. Epub 2020 Feb 3.
PMID: 31978299
Hu H, Bajorath J. Simplified activity cliff network representations with high interpretability and
immediate access to SAR information. J Comput Aided Mol Des. 2020 Sep;34(9):943-952. doi:
10.1007/s10822-020-00319-9. Epub 2020 Jun 5. PMID: 32500478
Hu H, Bajorath J. Increasing the public activity cliff knowledge base with new categories of activity
cliffs. Future Sci OA. 2020 Apr 15;6(5):FSO472. doi: 10.2144/fsoa-2020-0020. PMID: 32518687
Hu H, Bajorath J. Evidence for the presence of core structure-dependent activity cliffs. Future Med
Chem. 2020 Aug;12(16):1451-1455. doi: 10.4155/fmc-2020-0157. Epub 2020 Jul 8. PMID: 32638617
Hu H, Bajorath J. Activity cliffs produced by single-atom modification of active compounds:
Systematic identification and rationalization based on X-ray structures. Eur J Med Chem. 2020 Dec
1;207:112846. doi: 10.1016/j.ejmech.2020.112846. Epub 2020 Sep 16. PMID: 32977219
Hu H, Bajorath J. Data set of activity cliffs with single-atom modification and associated X-ray structure
information for medicinal and computational chemistry applications. Data Brief. 2020 Oct
1;33:106364. doi: 10.1016/j.dib.2020.106364. eCollection 2020 Dec. PMID: 33088875
Hu H, Bajorath J. Introducing a new category of activity cliffs combining different compound similarity
criteria. RSC Med Chem. 2020 Jan 7;11(1):132-141. doi: 10.1039/c9md00463g. eCollection 2020
Jan 1. PMID: 33479613
Imran S, Neeland MR, Shepherd R, Messina N, Perrett KP, Netea MG, Curtis N, Saffery R, Novakovic B. A
Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy. iScience. 2020 Jun
26;23(6):101171. doi: 10.1016/j.isci.2020.101171. Epub 2020 May 17. PMID: 32480123
Imura E, Shimada-Niwa Y, Nishimura T, Hückesfeld S, Schlegel P, Ohhara Y, Kondo S, Tanimoto H,
Cardona A, Pankratz MJ, Niwa R. The Corazonin-PTTH Neuronal Axis Controls Systemic Body
Growth by Regulating Basal Ecdysteroid Biosynthesis in Drosophila melanogaster. Curr Biol. 2020
Jun 8;30(11):2156-2165.e5. doi: 10.1016/j.cub.2020.03.050. Epub 2020 May 7. PMID: 32386525
Iqbal J, Vogt M, Bajorath J. Computational Method for Quantitative Comparison of Activity Landscapes
on the Basis of Image Data. Molecules. 2020 Aug 29;25(17):3952. doi: 10.3390/molecules25173952.
PMID: 32872506
Iqbal J, Vogt M, Bajorath J. Quantitative Comparison of Three-Dimensional Activity Landscapes of
Compound Data Sets Based upon Topological Features. ACS Omega. 2020 Sep 10;5(37):24111-
24117. doi: 10.1021/acsomega.0c03659. eCollection 2020 Sep 22. PMID: 32984733 Free PMC
article.
Iqbal J, Vogt M, Bajorath J. Activity landscape image analysis using convolutional neural networks. J
Cheminform. 2020 May 18;12(1):34. doi: 10.1186/s13321-020-00436-5. PMID: 33431003 Free PMC
article.
8Kaiser F, Hartweg J, Jansky S, Pelusi N, Kubaczka C, Sharma N, Nitsche D, Langkabel J, Schorle H. Persistent
Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting
in Severely Disrupted Placental Structure and Functionality. Int J Mol Sci. 2020 Jul 31;21(15):5503.
doi: 10.3390/ijms21155503. PMID: 32752102
Kalafati L, Kourtzelis I, Schulte-Schrepping J, Li X, Hatzioannou A, Grinenko T, Hagag E, Sinha A, Has C,
Dietz S, de Jesus Domingues AM, Nati M, Sormendi S, Neuwirth A, Chatzigeorgiou A, Ziogas A,
Lesche M, Dahl A, Henry I, Subramanian P, Wielockx B, Murray P, Mirtschink P, Chung KJ, Schultze
JL, Netea MG, Hajishengallis G, Verginis P, Mitroulis I, Chavakis T. Innate Immune Training of
Granulopoiesis Promotes Anti-tumor Activity. Cell. 2020 Oct 29;183(3):771-785.e12. doi: 10.1016/j.
cell.2020.09.058. PMID: 33125892
Kannambath S, Jarvis JN, Wake RM, Longley N, Loyse A, Matzaraki V, Aguirre-Gamboa R, Wijmenga C,
Doyle R, Paximadis M, Tiemessen CT, Kumar V, Pittman A, Meintjes G, Harrison TS, Netea MG,
Bicanic T. Genome-Wide Association Study Identifies Novel Colony Stimulating Factor 1 Locus
Conferring Susceptibility to Cryptococcosis in Human Immunodeficiency Virus-Infected South
Africans. Open Forum Infect Dis. 2020 Oct 16;7(11):ofaa489. doi: 10.1093/ofid/ofaa489. eCollection
2020 Nov. PMID: 33269293
Karagiannis F, Masouleh SK, Wunderling K, Surendar J, Schmitt V, Kazakov A, Michla M, Hölzel M, Thiele
C, Wilhelm C. Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway
Inflammation. Immunity. 2020 Apr 14;52(4):620-634.e6. doi: 10.1016/j.immuni.2020.03.003. Epub
2020 Apr 7. PMID: 32268121
Keating ST, Groh L, van der Heijden CDCC, Rodriguez H, Dos Santos JC, Fanucchi S, Okabe J, Kaipananickal
H, van Puffelen JH, Helder L, Noz MP, Matzaraki V, Li Y, de Bree LCJ, Koeken VACM, Moorlag SJCFM,
Mourits VP, Domínguez-Andrés J, Oosting M, Bulthuis EP, Koopman WJH, Mhlanga M, El-Osta
A, Joosten LAB, Netea MG, Riksen NP. The Set7 Lysine Methyltransferase Regulates Plasticity in
Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan. Cell Rep. 2020
Apr 21;31(3):107548. doi: 10.1016/j.celrep.2020.107548. PMID: 32320649
Keating ST, Groh L, Thiem K, Bekkering S, Li Y, Matzaraki V, van der Heijden CDCC, van Puffelen JH,
Lachmandas E, Jansen T, Oosting M, de Bree LCJ, Koeken VACM, Moorlag SJCFM, Mourits VP, van
Diepen J, Strienstra R, Novakovic B, Stunnenberg HG, van Crevel R, Joosten LAB, Netea MG, Riksen
NP. Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density
lipoprotein. J Mol Med (Berl). 2020 Jun;98(6):819-831. doi: 10.1007/s00109-020-01915-w. Epub
2020 Apr 30. PMID: 32350546
Keating ST, Groh L, Thiem K, Bekkering S, Li Y, Matzaraki V, van der Heijden CDCC, van Puffelen JH,
Lachmandas E, Jansen T, Oosting M, de Bree LCJ, Koeken VACM, Moorlag SJCFM, Mourits VP, van
Diepen J, Stienstra R, Novakovic B, Stunnenberg HG, van Crevel R, Joosten LAB, Netea MG, Riksen
NP. Correction to: Rewiring of glucose metabolism defines trained immunity induced by oxidized
low-density lipoprotein. J Mol Med (Berl). 2020 Jul;98(7):1051. doi: 10.1007/s00109-020-01939-2.
PMID: 32529344
Klück V, van Deuren RC, Cavalli G, Shaukat A, Arts P, Cleophas MC, Crișan TO, Tausche AK, Riches P, Dalbeth
N, Stamp LK, Hindmarsh JH, Jansen TLTA, Janssen M, Steehouwer M, Lelieveld S, van de Vorst M,
Gilissen C, Dagna L, Van de Veerdonk FL, Eisenmesser EZ, Kim S, Merriman TR, Hoischen A, Netea
MG, Dinarello CA, Joosten LA. Rare genetic variants in interleukin-37 link this anti-inflammatory
cytokine to the pathogenesis and treatment of gout. Ann Rheum Dis. 2020 Apr;79(4):536-544. doi:
10.1136/annrheumdis-2019-216233. Epub 2020 Feb 29. PMID: 32114511
Koeken VACM, van der Pasch ES, Leijte GP, Mourits VP, de Bree LCJ, Moorlag SJCFM, Budnick I, Idh N,
Lerm M, Kox M, van Laarhoven A, Netea MG, van Crevel R. The effect of BCG vaccination on
alveolar macrophages obtained from induced sputum from healthy volunteers. Cytokine. 2020
Sep;133:155135. doi: 10.1016/j.cyto.2020.155135. Epub 2020 Jun 10. PMID: 32534356
9Koeken VACM, Ganiem AR, Dian S, Ruslami R, Chaidir L, Netea MG, Kumar V, Alisjahbana B, van Crevel
R, van Laarhoven A. Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but
not associated with mortality. Tuberculosis (Edinb). 2020 Nov 11;126:102019. doi: 10.1016/j.
tube.2020.102019. Online ahead of print. PMID: 33202351
Koeken VA, de Bree LCJ, Mourits VP, Moorlag SJ, Walk J, Cirovic B, Arts RJ, Jaeger M, Dijkstra H, Lemmers
H, Joosten LA, Benn CS, van Crevel R, Netea MG. BCG vaccination in humans inhibits systemic
inflammation in a sex-dependent manner. J Clin Invest. 2020 Oct 1;130(10):5591-5602. doi:
10.1172/JCI133935. PMID: 32692728 Free PMC article.
Kooistra EJ, Waalders NJB, Grondman I, Janssen NAF, de Nooijer AH, Netea MG, van de Veerdonk FL,
Ewalds E, van der Hoeven JG, Kox M, Pickkers P; RCI-COVID-19 Study Group. Anakinra treatment
in critically ill COVID-19 patients: a prospective cohort study. Crit Care. 2020 Dec 10;24(1):688. doi:
10.1186/s13054-020-03364-w. PMID: 33302991
Kopf A, Renkawitz J, Hauschild R, Girkontaite I, Tedford K, Merrin J, Thorn-Seshold O, Trauner D, Häcker H,
Fischer KD, Kiermaier E, Sixt M. Microtubules control cellular shape and coherence in amoeboid
migrating cells. J Cell Biol. 2020 Jun 1;219(6):e201907154. doi: 10.1083/jcb.201907154. PMID:
32379884
Kottmeier R, Bittern J, Schoofs A, Scheiwe F, Matzat T, Pankratz M, Klämbt C. Wrapping glia regulates
neuronal signaling speed and precision in the peripheral nervous system of Drosophila. Nat
Commun. 2020 Sep 8;11(1):4491. doi: 10.1038/s41467-020-18291-1. PMID: 32901033 Free PMC
article.
Krebs CF, Schlitzer A, Kurts C. Drawing a single-cell landscape of the human kidney in (pseudo)-space
and time. Kidney Int. 2020 May;97(5):842-844. doi: 10.1016/j.kint.2020.01.011. PMID: 32331591
Lang T, Hochheimer N. Tetraspanins. Curr Biol. 2020 Mar 9;30(5):R204-R206. doi: 10.1016/j.
cub.2020.01.007. PMID: 32155418
Laufkötter O, Laufer S, Bajorath J. Identifying representative kinases for inhibitor evaluation via
systematic analysis of compound-based target relationships. Eur J Med Chem. 2020 Oct
15;204:112641. doi: 10.1016/j.ejmech.2020.112641. Epub 2020 Jul 18. PMID: 32745818
Laufkötter O, Laufer S, Bajorath J. Kinase inhibitor data set for systematic analysis of representative
kinases across the human kinome. Data Brief. 2020 Aug 15;32:106189. doi: 10.1016/j.
dib.2020.106189. eCollection 2020 Oct. PMID: 32904416
Lauterbach MA, Saavedra V, Mangan MSJ, Penno A, Thiele C, Latz E, Kuerschner L. 1-Deoxysphingolipids
cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.
Autophagy. 2020 Aug 24:1-15. doi: 10.1080/15548627.2020.1804677. Online ahead of print. PMID:
32835606
Liepelt A, Hohlstein P, Gussen H, Xue J, Aschenbrenner AC, Ulas T, Buendgens L, Warzecha KT, Bartneck
M, Luedde T, Trautwein C, Schultze JL, Koch A, Tacke F. Differential Gene Expression in Circulating
CD14+ Monocytes Indicates the Prognosis of Critically Ill Patients with Sepsis. J Clin Med. 2020 Jan
2;9(1):127. doi: 10.3390/jcm9010127. PMID: 31906585
Lindqvist R, Rosendal E, Weber E, Asghar N, Schreier S, Lenman A, Johansson M, Dobler G, Bestehorn
M, Kröger A, Överby AK. The envelope protein of tick-borne encephalitis virus influences neuron
entry, pathogenicity, and vaccine protection. J Neuroinflammation. 2020 Sep 28;17(1):284. doi:
10.1186/s12974-020-01943-w. PMID: 32988388
López-López E, Bajorath J, Medina-Franco JL. Informatics for Chemistry, Biology, and Biomedical
Sciences. J Chem Inf Model. 2021 Jan 25;61(1):26-35. doi: 10.1021/acs.jcim.0c01301. Epub 2020
Dec 31. PMID: 33382611
10Ma Y, Centola M, Keppner D, Famulok M. Interlocked DNA Nanojoints for Reversible Thermal Sensing.
Angew Chem Int Ed Engl. 2020 Jul 20;59(30):12455-12459. doi: 10.1002/anie.202003991. Epub
2020 Jul 1. PMID: 32567796
Madsen AMR, Schaltz-Buchholzer F, Benfield T, Bjerregaard-Andersen M, Dalgaard LS, Dam C, Ditlev
SB, Faizi G, Johansen IS, Kofoed PE, Kristensen GS, Loekkegaard ECL, Mogensen CB, Mohamed L,
Ostenfeld A, Oedegaard ES, Soerensen MK, Wejse C, Jensen AKG, Nielsen S, Krause TG, Netea MG,
Aaby P, Benn CS. Using BCG vaccine to enhance non-specific protection of health care workers
during the COVID-19 pandemic: A structured summary of a study protocol for a randomised
controlled trial in Denmark. Trials. 2020 Sep 17;21(1):799. doi: 10.1186/s13063-020-04714-3. PMID:
32943115
Maggiora G, Medina-Franco JL, Iqbal J, Vogt M, Bajorath J. From Qualitative to Quantitative Analysis of
Activity and Property Landscapes. J Chem Inf Model. 2020 Dec 28;60(12):5873-5880. doi: 10.1021/
acs.jcim.0c01249. Epub 2020 Nov 18. PMID: 33205984
Mantovani A, Netea MG. Trained Innate Immunity, Epigenetics, and Covid-19. N Engl J Med. 2020 Sep
10;383(11):1078-1080. doi: 10.1056/NEJMcibr2011679. PMID: 32905684
Manuel Sánchez-Maldonado J, Martínez-Bueno M, Canhão H, Ter Horst R, Muñoz-Peña S, Moñiz-Díez
A, Rodríguez-Ramos A, Escudero A, Sorensen SB, Hetland ML, Ferrer MA, Glintborg B, Filipescu I,
Pérez-Pampin E, Conesa-Zamora P, García A, den Broeder A, De Vita S, Hove Jacobsen SE, Collantes
E, Quartuccio L, Netea MG, Li Y, Fonseca JE, Jurado M, López-Nevot MÁ, Coenen MJH, Andersen V,
Cáliz R, Sainz J. NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis
and response to TNF inhibitors: Results from the REPAIR consortium. Sci Rep. 2020 Mar 9;10(1):4316.
doi: 10.1038/s41598-020-61331-5. PMID: 32152480
Mayer G, Legen T, Patwari T, Weber AM. Hunting Cells for Gentle Liberation. Cell Chem Biol. 2020 Mar
19;27(3):257-258. doi: 10.1016/j.chembiol.2020.02.006. PMID: 32200913
Mayer G, Renzl C, Kakoti A. Aptamer-mediated reversible transactivation of gene expression by light.
Angew Chem Int Ed Engl. 2020 Aug 31. doi: 10.1002/anie.202009240. [Epub ahead of print] Pub-
Med PMID: 32865316.
Melaiu O, Macauda A, Sainz J, Calvetti D, Facioni MS, Maccari G, Ter Horst R, Netea MG, Li Y, Grząśko
N, Moreno V, Jurczyszyn A, Jerez A, Watek M, Varkonyi J, Garcia-Sanz R, Kruszewski M, Dudziński
M, Kadar K, Jacobsen SEH, Mazur G, Andersen V, Rybicka M, Zawirska D, Raźny M, Zaucha JM,
Ostrovsky O, Iskierka-Jazdzewska E, Reis RM, Stępień A, Beider K, Nagler A, Druzd-Sitek A, Marques
H, Martìnez-Lopez J, Lesueur F, Avet-Loiseau H, Vangsted AJ, Krawczyk-Kulis M, Butrym A, Jamroziak
K, Dumontet C, Vogel U, Rymko M, Pelosini M, Subocz E, Szombath G, Sarasquete ME, Silvestri R,
Morani F, Landi S, Campa D, Canzian F, Gemignani F. Common gene variants within 3’-untranslated
regions as modulators of multiple myeloma risk and survival. Int J Cancer. 2020 Nov 5. doi: 10.1002/
ijc.33377. Online ahead of print. PMID: 33152124
Merches K, Schiavi A, Weighardt H, Steinwachs S, Teichweyde N, Förster I, Hochrath K, Schumak B, Ventura
N, Petzsch P, Köhrer K, Esser C. AHR Signaling Dampens Inflammatory Signature in Neonatal Skin
γδ T Cells. Int J Mol Sci. 2020 Mar 24;21(6):2249. doi: 10.3390/ijms21062249. PMID: 32213963
Messina NL, Netea MG, Curtis N. The impact of human single nucleotide polymorphisms on
Bacillus Calmette-Guérin responses. Vaccine. 2020 Sep 11;38(40):6224-6235. doi: 10.1016/j.
vaccine.2020.07.032. Epub 2020 Aug 18. PMID: 32826104
Miljković F, Rodríguez-Pérez R, Bajorath J. Machine Learning Models for Accurate Prediction of
Kinase Inhibitors with Different Binding Modes. J Med Chem. 2020 Aug 27;63(16):8738-8748. doi:
10.1021/acs.jmedchem.9b00867. Epub 2019 Aug 30. PMID: 31469557
11Miljković F, Bajorath J. Data structures for computational compound promiscuity analysis and exemplary
applications to inhibitors of the human kinome. J Comput Aided Mol Des. 2020 Jan;34(1):1-10. doi:
10.1007/s10822-019-00266-0. Epub 2019 Dec 2. PMID: 31792884
Miroschnikow A, Schlegel P, Pankratz MJ. Making Feeding Decisions in the Drosophila Nervous
System. Curr Biol. 2020 Jul 20;30(14):R831-R840. doi: 10.1016/j.cub.2020.06.036. PMID: 32693083
Moorlag SJCFM, Khan N, Novakovic B, Kaufmann E, Jansen T, van Crevel R, Divangahi M, Netea MG.
β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A
Key Role for IL-1. Cell Rep. 2020 May 19;31(7):107634. doi: 10.1016/j.celrep.2020.107634. PMID:
32433977
Moorlag SJCFM, van Deuren RC, van Werkhoven CH, Jaeger M, Debisarun P, Taks E, Mourits VP, Koeken
VACM, de Bree LCJ, Ten Doesschate T, Cleophas MC, Smeekens S, Oosting M, van de Veerdonk FL,
Joosten LAB, Ten Oever J, van der Meer JWM, Curtis N, Aaby P, Stabell-Benn C, Giamarellos-Bourboulis
EJ, Bonten M, van Crevel R, Netea MG. Safety and COVID-19 Symptoms in Individuals Recently
Vaccinated with BCG: a Retrospective Cohort Study. Cell Rep Med. 2020 Aug 25;1(5):100073. doi:
10.1016/j.xcrm.2020.100073. Epub 2020 Aug 5. PMID: 32838341
Moorlag SJCFM, Rodriguez-Rosales YA, Gillard J, Fanucchi S, Theunissen K, Novakovic B, de Bont CM,
Negishi Y, Fok ET, Kalafati L, Verginis P, Mourits VP, Koeken VACM, de Bree LCJ, Pruijn GJM, Fenwick C,
van Crevel R, Joosten LAB, Joosten I, Koenen H, Mhlanga MM, Diavatopoulos DA, Chavakis T, Netea
MG. BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils. Cell
Rep. 2020 Nov 17;33(7):108387. doi: 10.1016/j.celrep.2020.108387. PMID: 33207187
Mourits VP, Arts RJW, Novakovic B, Matzaraki V, de Bree LCJ, Koeken VACM, Moorlag SJCFM, van Puffelen
JH, Groh L, van der Heijden CDCC, Keating ST, Netea MG, Oosting M, Joosten LAB. The role of Toll-
like receptor 10 in modulation of trained immunity. Immunology. 2020 Mar;159(3):289-297. doi:
10.1111/imm.13145. Epub 2019 Nov 26. PMID: 31671203
Mourits VP, Koeken VACM, de Bree LCJ, Moorlag SJCFM, Chu WC, Xu X, Dijkstra H, Lemmers H, Joosten
LAB, Wang Y, van Crevel R, Netea MG. BCG-Induced Trained Immunity in Healthy Individuals: The
Effect of Plasma Muramyl Dipeptide Concentrations. J Immunol Res. 2020 Jun 15;2020:5812743.
doi: 10.1155/2020/5812743. eCollection 2020. PMID: 32626788
Netea MG, Domínguez-Andrés J, Eleveld M, Op den Camp HJM, van der Meer JWM, Gow NAR, de Jonge
MI. Immune recognition of putative alien microbial structures: Host-pathogen interactions in the
age of space travel. PLoS Pathog. 2020 Jan 30;16(1):e1008153. doi: 10.1371/journal.ppat.1008153.
eCollection 2020 Jan. PMID: 31999804
Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der
Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC,
Xavier RJ, Latz E. Defining trained immunity and its role in health and disease. Nat Rev Immunol.
2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4. PMID: 32132681
Neubert P, Homann A, Wendelborn D, Bär AL, Krampert L, Trum M, Schröder A, Ebner S, Weichselbaum
A, Schatz V, Linz P, Veelken R, Schulte-Schrepping J, Aschenbrenner AC, Quast T, Kurts C,
Geisberger S, Kunzelmann K, Hammer K, Binger KJ, Titze J, Müller DN, Kolanus W, Schultze JL,
Wagner S, Jantsch J. NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLoS
Biol. 2020 Jun 22;18(6):e3000722. doi: 10.1371/journal.pbio.3000722. eCollection 2020 Jun. PMID:
32569301
Noz MP, Bekkering S, Groh L, Nielen TM, Lamfers EJ, Schlitzer A, El Messaoudi S, van Royen N, Huys EH,
Preijers FW, Smeets EM, Aarntzen EH, Zhang B, Li Y, Bremmers ME, van der Velden WJ, Dolstra H,
Joosten LA, Gomes ME, Netea MG, Riksen NP. Reprogramming of bone marrow myeloid progenitor
cells in patients with severe coronary artery disease. Elife. 2020 Nov 10;9:e60939. doi: 10.7554/
eLife.60939. PMID: 33168134
12Ochando J, Fayad ZA, Madsen JC, Netea MG, Mulder WJM. Trained immunity in organ transplantation.
Am J Transplant. 2020 Jan;20(1):10-18. doi: 10.1111/ajt.15620. Epub 2019 Oct 28. PMID: 31561273
O’Neill LAJ, Netea MG. BCG-induced trained immunity: can it offer protection against COVID-19? Nat
Rev Immunol. 2020 Jun;20(6):335-337. doi: 10.1038/s41577-020-0337-y. Review. PMID: 32393823
Pecht T, Aschenbrenner AC, Ulas T, Succurro A. Modeling population heterogeneity from microbial
communities to immune response in cells. Cell Mol Life Sci. 2020 Feb;77(3):415-432. doi: 10.1007/
s00018-019-03378-w. Epub 2019 Nov 25. PMID: 31768606
Perrot N, Valerio V, Moschetta D, Boekholdt SM, Dina C, Chen HY, Abner E, Martinsson A, Manikpurage HD,
Rigade S, Capoulade R, Mass E, Clavel MA, Le Tourneau T, Messika-Zeitoun D, Wareham NJ, Engert
JC, Polvani G, Pibarot P, Esko T, Smith JG, Mathieu P, Thanassoulis G, Schott JJ, Bossé Y, Camera M,
Thériault S, Poggio P, Arsenault BJ. Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic
Valve Stenosis. JACC Basic Transl Sci. 2020 Jul 1;5(7):649-661. doi: 10.1016/j.jacbts.2020.05.004.
eCollection 2020 Jul. PMID: 32760854
Pestana F, Edwards-Faret G, Belgard TG, Martirosyan A, Holt MG. No Longer Underappreciated: The
Emerging Concept of Astrocyte Heterogeneity in Neuroscience. Brain Sci. 2020 Mar 13;10(3):168.
doi: 10.3390/brainsci10030168. PMID: 32183137
Pilsl S, Morgan C, Choukeife M, Möglich A, Mayer G. Optoribogenetic control of regulatory RNA
molecules. Nat Commun. 2020 Sep 24;11(1):4825. doi: 10.1038/s41467-020-18673-5. PMID:
32973178
Priem B, van Leent MMT, Teunissen AJP, Sofias AM, Mourits VP, Willemsen L, Klein ED, Oosterwijk RS,
Meerwaldt AE, Munitz J, Prévot G, Vera Verschuur A, Nauta SA, van Leeuwen EM, Fisher EL, de
Jong KAM, Zhao Y, Toner YC, Soultanidis G, Calcagno C, Bomans PHH, Friedrich H, Sommerdijk N,
Reiner T, Duivenvoorden R, Zupančič E, Di Martino JS, Kluza E, Rashidian M, Ploegh HL, Dijkhuizen
RM, Hak S, Pérez-Medina C, Bravo-Cordero JJ, de Winther MPJ, Joosten LAB, van Elsas A, Fayad ZA,
Rialdi A, Torre D, Guccione E, Ochando J, Netea MG, Griffioen AW, Mulder WJM. Trained Immunity-
Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint
Inhibition. Cell. 2020 Oct 29;183(3):786-801.e19. doi: 10.1016/j.cell.2020.09.059. PMID: 33125893
Rabold K, Aschenbrenner A, Thiele C, Boahen CK, Schiltmans A, Smit JWA, Schultze JL, Netea MG,
Adema GJ, Netea-Maier RT. Enhanced lipid biosynthesis in human tumor-induced macrophages
contributes to their protumoral characteristics. J Immunother Cancer. 2020 Sep;8(2):e000638. doi:
10.1136/jitc-2020-000638. PMID: 32943450
Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca
S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner
N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni JC, Marti-Renom MA,
Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C,
Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ,
Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T; LifeTime Community
Working Groups. LifeTime and improving European healthcare through cell-based interceptive
medicine. Nature. 2020 Nov;587(7834):377-386. doi: 10.1038/s41586-020-2715-9. Epub 2020 Sep
7. PMID: 32894860
Rawish E, Nickel L, Schuster F, Stölting I, Frydrychowicz A, Saar K, Hübner N, Othman A, Kuerschner
L, Raasch W. Telmisartan prevents development of obesity and normalizes hypothalamic lipid
droplets. J Endocrinol. 2020 Jan 1;244(1):95-110. doi: 10.1530/JOE-19-0319. PMID: 31585441
Renzl C, Kakoti A, Mayer G. Aptamer-Mediated Reversible Transactivation of Gene Expression by Light.
Angew Chem Int Ed Engl. 2020 Dec 7;59(50):22414-22418. doi: 10.1002/anie.202009240. Epub
2020 Oct 2. PMID: 32865316
13Rigon L, Kucharowski N, Eckardt F, Bauer R. Modeling Mucopolysaccharidosis Type II in the Fruit
Fly by Using the RNA Interference Approach. Life (Basel). 2020 Oct 30;10(11):263. doi: 10.3390/
life10110263. PMID: 33142967
Rodríguez-Pérez R, Bajorath J. Interpretation of Compound Activity Predictions from Complex
Machine Learning Models Using Local Approximations and Shapley Values. J Med Chem. 2020 Aug
27;63(16):8761-8777. doi: 10.1021/acs.jmedchem.9b01101. Epub 2019 Sep 26. PMID: 31512867
Rodríguez-Pérez R, Bajorath J. Interpretation of machine learning models using shapley values:
application to compound potency and multi-target activity predictions. J Comput Aided Mol Des.
2020 Oct;34(10):1013-1026. doi: 10.1007/s10822-020-00314-0. Epub 2020 May 2. PMID: 32361862
Rodríguez-Pérez R, Miljković F, Bajorath J. Assessing the information content of structural and
protein-ligand interaction representations for the classification of kinase inhibitor binding modes
via machine learning and active learning. J Cheminform. 2020 May 24;12(1):36. doi: 10.1186/
s13321-020-00434-7. PMID: 33431025
Rosati D, Bruno M, Jaeger M, Ten Oever J, Netea MG. Recurrent Vulvovaginal Candidiasis: An Immunological
Perspective. Microorganisms. 2020 Jan 21;8(2):144. doi: 10.3390/microorganisms8020144. PMID:
31972980
Rosati D, Bruno M, Jaeger M, Kullberg BJ, van de Veerdonk F, Netea MG, Ten Oever J. An exaggerated
monocyte-derived cytokine response to Candida hyphae in patients with recurrent vulvovaginal
candidiasis. J Infect Dis. 2020 Jul 23:jiaa444. doi: 10.1093/infdis/jiaa444. Online ahead of print.
PMID: 32702099
Rösler B, Heinhuis B, Wang X, Silvestre R, Joosten LAB, Netea MG, Arts P, Mantere T, Lefeber DJ, Hoischen
A, van de Veerdonk FL. Mimicking Behçet’s disease: GM-CSF gain of function mutation in a family
suffering from a Behçet’s disease-like disorder marked by extreme pathergy. Clin Exp Immunol.
2020 Dec 22. doi: 10.1111/cei.13568. Online ahead of print. PMID: 33349924
Rother N, Yanginlar C, Lindeboom RGH, Bekkering S, van Leent MMT, Buijsers B, Jonkman I, de Graaf
M, Baltissen M, Lamers LA, Riksen NP, Fayad ZA, Mulder WJM, Hilbrands LB, Joosten LAB, Netea
MG, Vermeulen M, van der Vlag J, Duivenvoorden R. Hydroxychloroquine Inhibits the Trained
Innate Immune Response to Interferons. Cell Rep Med. 2020 Nov 10;1(9):100146. doi: 10.1016/j.
xcrm.2020.100146. eCollection 2020 Dec 22. PMID: 33377122
Samuel AZ, Miyaoka R, Ando M, Gaebler A, Thiele C, Takeyama H. Molecular profiling of lipid droplets
inside HuH7 cells with Raman micro-spectroscopy. Commun Biol. 2020 Jul 10;3(1):372. doi:
10.1038/s42003-020-1100-4. PMID: 32651434
Sánchez-Maldonado JM, Campa D, Springer J, Badiola J, Niazi Y, Moñiz-Díez A, Hernández-Mohedo F,
González-Sierra P, Ter Horst R, Macauda A, Brezina S, Cunha C, Lackner M, López-Nevot MA, Fianchi
L, Pagano L, López-Fernández E, Potenza L, Luppi M, Moratalla L, Rodríguez-Sevilla JJ, Fonseca
JE, Tormo M, Solano C, Clavero E, Romero A, Li Y, Lass-Flörl C, Einsele H, Vazquez L, Loeffler J,
Hemminki K, Carvalho A, Netea MG, Gsur A, Dumontet C, Canzian F, Försti A, Jurado M, Sainz J.
Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results
from the NuCLEAR consortium. Blood Cancer J. 2020 Jul 16;10(7):75. doi: 10.1038/s41408-020-
00341-y. PMID: 32678078
Sánchez-Maldonado JM, Moñiz-Díez A, Ter Horst R, Campa D, Cabrera-Serrano AJ, Martínez-Bueno M,
Garrido-Collado MDP, Hernández-Mohedo F, Fernández-Puerta L, López-Nevot MÁ, Cunha C,
González-Sierra PA, Springer J, Lackner M, Alcazar-Fuoli L, Fianchi L, Aguado JM, Pagano L, López-
Fernández E, Clavero E, Potenza L, Luppi M, Moratalla L, Solano C, Sampedro A, Cuenca-Estrella
M, Lass-Flörl C, Pcraga Study Group, Canzian F, Loeffler J, Li Y, Einsele H, Netea MG, Vázquez L,
Carvalho A, Jurado M, Sainz J. Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence
the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of
14the aspBIOmics Consortium. J Fungi (Basel). 2020 Dec 23;7(1):4. doi: 10.3390/jof7010004. PMID:
33374839
Schaefer K, Dambuza IM, Dall’Angelo S, Yuecel R, Jaspars M, Trembleau L, Zanda M, Brown GD, Netea
MG, Gow NAR. A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential
Biosecurity Risk in the Retrieval of Exo-Microorganisms. Microorganisms. 2020 Jul 17;8(7):1066.
doi: 10.3390/microorganisms8071066. PMID: 32708909
Schanz O, Chijiiwa R, Cengiz SC, Majlesain Y, Weighardt H, Takeyama H, Förster I. Dietary AhR Ligands
Regulate AhRR Expression in Intestinal Immune Cells and Intestinal Microbiota Composition. Int J
Mol Sci. 2020 Apr 30;21(9):3189. doi: 10.3390/ijms21093189. PMID: 32366032
Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T,
Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M,
Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne
A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim
KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk
HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert
K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R,
Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner
AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE; Deutsche COVID-19 OMICS Initiative
(DeCOI).Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 2020 Sep
17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001. Epub 2020 Aug 5 PMID: 32810438
Schuurbiers MMF, Bruno M, Zweijpfenning SMH, Magis-Escurra C, Boeree M, Netea MG, van Ingen J,
van de Veerdonk F, Hoefsloot W. Immune defects in patients with pulmonary Mycobacterium
abscessus disease without cystic fibrosis. ERJ Open Res. 2020 Nov 10;6(4):00590-2020. doi:
10.1183/23120541.00590-2020. eCollection 2020 Oct. PMID: 33263065
Scriba TJ, Netea MG, Ginsberg AM. Key recent advances in TB vaccine development and understanding
of protective immune responses against Mycobacterium tuberculosis. Semin Immunol. 2020
Aug;50:101431. doi: 10.1016/j.smim.2020.101431. Epub 2020 Dec 2. PMID: 33279383
Sellin J, Fülle JB, Thiele C, Bauer R, Bülow MH. Free fatty acid determination as a tool for modeling
metabolic diseases in Drosophila. J Insect Physiol. 2020 Oct;126:104090. doi: 10.1016/j.
jinsphys.2020.104090. Epub 2020 Jul 28. PMID: 32730782
Sohrabi Y, Dos Santos JC, Dorenkamp M, Findeisen H, Godfrey R, Netea MG, Joosten LA. Trained
immunity as a novel approach against COVID-19 with a focus on Bacillus Calmette-Guérin vaccine:
mechanisms, challenges and perspectives. Clin Transl Immunology. 2020 Dec 22;9(12):e1228. doi:
10.1002/cti2.1228. eCollection 2020. PMID: 33363733
Stumpfe D, Hu H, Bajorath J. Computational method for the identification of third generation activity
cliffs. MethodsX. 2020 Jan 14;7:100793. doi: 10.1016/j.mex.2020.100793. eCollection 2020. PMID:
31993342
Stumpfe D, Bajorath J. Current Trends, Overlooked Issues, and Unmet Challenges in Virtual Screening.
J Chem Inf Model. 2020 Sep 28;60(9):4112-4115. doi: 10.1021/acs.jcim.9b01101. Epub 2020 Feb 3.
PMID: 32011879
Stumpfe D, Hu H, Bajorath J. Advances in exploring activity cliffs. J Comput Aided Mol Des. 2020
Sep;34(9):929-942. doi: 10.1007/s10822-020-00315-z. Epub 2020 May 5. PMID: 32367387
Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D,
Sampaziotis F, Worlock KB, Yoshida M, Barnes JL; HCA Lung Biological Network. SARS-CoV-2 entry
factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med.
2020 May; 26(5):681-687. doi: 10.1038/s41591-020-0868-6. Epub 2020 Apr 23.PMID: 32327758
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