Program 2016 Neuroscience - Society for Neuroscience
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GENER AL INFORMATION
Neuroscience
2016 Program
San Diego | November 12–16
2 | NEUROSCIE NCE 2 016
Information at a Glance
Note: The themes have been updated for
Important Phone Numbers Neuroscience 2016
Annual Meeting Headquarters Office Exhibit Management
Logistics and Programming San Diego Convention Center: Lobby D
Logistics (619) 525-6240
San Diego Convention Center: Sails Pavilion Key to Poster Floor by Themes
First Aid, Hospital and Urgent
(619) 525-6200 Theme
Care Numbers
A. Development
Programming First Aid Station
B. Neural Excitability, Synapses, and Glia
San Diego Convention Center: Sails Pavilion San Diego Convention Center:
C. Neurodegenerative Disorders and Injury
(619) 525-6205 Box Office G
D. Sensory Systems
(619) 525-6211
Volunteer Leadership Lounge E. Motor Systems
San Diego Convention Center: Room 14A Scripps Mercy Hospital F. Integrative Physiology and Behavior
(619) 525-6235 4077 Fifth Avenue G. Motivation and Emotion
San Diego, CA 92103 H. Cognition
General Information Booths
(619) 294-8111 I. Techniques
San Diego Convention Center
J. History and Education
Front of Box Office A, (619) 525-6224 Sharp Rees – Stealy Downtown
Lobby D, (619) 525-6225 San Diego Urgent Care NOTE: Theme J Posters will be located in Hall
Sails Pavilion, (619) 525-6226 300 Fir Street B beginning at 1 p.m. on Saturday, November
San Diego, CA 92101 12, and will remain posted until 5 p.m., Sunday,
Press Office
(858) 499-2600 November 13.
Press Room
San Diego Convention Center: Room 15B
(619) 525-6230
Code of Conduct at SfN Events positive environment. At the convention center, designated Human Resources Officer in the
onsite medical and security personnel are available SfN headquarters office at each meeting
SfN is committed to supporting discovery and
directly or through the SfN headquarters office. convention center, or sent via email to
scientific dialogue, and to fostering a welcoming
hrofficer@sfn.org. The HR Officer will facilitate the
community in which all scientists are able to If attendees experience unwelcome or unsafe
completion of a report by a complainant. View the
contribute fully. The Society asserts that sexual situations anywhere in the city, attendees should
entire Code of Conduct at SfN Events statement
harassment and other harassing behaviors have swiftly contact local authorities (dial 9-1-1), and
for more information.
no place in a healthy scientific enterprise. We additional local social services resources are listed
expect all attendees, media, speakers, volunteers, in one convenient location at the federal website For more information, on SfN’s policy, please
organizers, venue staff, guests, and exhibitors at www.notalone.gov. Any official report of sexual go to: sfn.org/Member-Center/Professional-
SfN-organized events to help us ensure a safe and harassment should be brought to the Conduct/Code-of-Conduct-at-SfN-Events
3 | NEUROSCIE NCE 2 016
TABLE OF CONTENTS
Scientific Content Registration, Hotel, and Travel Resources
8 Program at a Glance 66 Registration 74 Attendee Resources
12 Featured Lectures 67 Navigating the Meeting 77 Speaker Resources
14 Special Lectures 68 Hotel Map 78 Exhibitor List
18 Symposia 69 Hotel List 82 Hotel Floor Plans
20 Minisymposia 71 Travel Information 88 Convention Center Floor Plans
24 Workshops, Meetings, and Events 71 Shuttle Schedule 95 Photo Credits
32 SfN‑Sponsored Socials 96 Council and Program Committee
35 Satellite Events and Non‑SfN Socials
39 List of Sessions by Theme and Day
62 Clinician-Scientists and Continuing
Medical Education
63 Awards in Neuroscience
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Experience the thrill of scientific discovery at the 46th
annual meeting of The Society for Neuroscience.
At Neuroscience 2016, you’ll experience the rich breadth of neuroscience, view innovative tools
and technologies, and discuss the future of the field with colleagues from around the world.
Plan Your Neuroscience Commitment to Environmental
2016 Experience Responsibility
Is your smartphone or tablet permanently affixed SfN is committed to minimizing its impact
to your hand? Then check out the meeting on the environment we share. Free printed
mobile app, available for download in copies of the Exhibit Guide and this general
iTunes™, and the Google Play App Store™, information Program book will be provided.
and the Neuroscience Meeting Planner at Please refer to the meeting mobile app or the
sfn.org/NMP, to plan your Neuroscience 2016 Neuroscience Meeting Planner for additional
experience. Both resources allow you to browse program information. The Neuroscience
Immerse Yourself in Neuroscience abstracts and select sessions to attend. Turn to Meeting Planner Viewing Area in the San Diego
The brain remains one of the greatest mysteries the meeting planner to build your itinerary, which Convention Center allows for easy access to the
in science. Explore the vast complexity can be synced with the app or downloaded online meeting planner.
of neuroscience by attending symposia, and printed.
A limited number of daily books are available for
workshops, and lectures at Neuroscience 2016.
Dynamic posters return for 2016 — don’t miss purchase on-site. Visit the Program and Exhibit
Be inspired by your colleagues’ research and
these interactive multimedia presentations. Each Guide Pick-up counter in Lobby A and Sails
learn new techniques and theories that can be
poster session will feature 10 dynamic posters. Pavilion for more information.
applied to your work.
Visit the Neuroscience Meeting Planner or the
Connect Through Social Media
Connecting a Diverse Field mobile app to add these innovative posters to
Share the excitement on SfN social media
A new friend, collaborator, or mentor may be your schedule.
channels using #SfN16 on Twitter, follow
right around the corner. Neuroscience 2016
Experience the annual meeting in a new way @Neuroscience2016 and @SfNtweets, and like
convenes the entire field of neuroscience,
with curated itineraries, which allow you to focus us on Facebook to receive important meeting
connecting you with peers at various stages
on a specific research area. Neuroscience 2016 updates and event information.
in their careers, in different disciplines, and
features 14 curated itineraries, which include
from all over the world. Meet colleagues and See You Next Year in
scientific sessions and SfN-Sponsored Socials
build relationships at social events, in between Washington, DC!
on a broad variety of topics selected by the
sessions, or in the Exhibit Hall. Neuroscience Mark your calendars for Neuroscience 2017 —
SfN Program Committee. Use the meeting
2016 is an unparalleled opportunity to find a November 11–15, 2017, in Washington, DC.
mobile app or Neuroscience Meeting Planner
new job or recruit top talent, receive unbiased
to view the 14 selected topics, download the
professional feedback, or connect with future
entire itinerary, or add selected sessions to
research partners.
your schedule.
5 | NEUROSCIE NCE 2 016
Annual Meeting Contributors
The Nemko Family
The Nemko Family
Nemko Prize in Cellular or
AbbVie
Molecular Neuroscience
Professional Development Workshops
The Grass Foundation Eli Lilly and Company Foundation
Albert and Ellen Grass Lecture, Julius Axelrod Prize
Donald B. Lindsley Prize in Behavioral
Bernice Grafstein, PhD Neuroscience, Latin America Training
Bernice Grafstein, PhD Program, Challenge Grant
Bernice Grafstein Award for Outstanding
Accomplishments in Mentoring Otsuka America Pharmaceutical, Inc.
Short Course (partial support)
Logos Biosystems, Inc.
Shuttle Buses
Biogen
The Gruber Foundation
Presidential Special Lecture, Pfizer
Peter and Patricia Gruber International
Annual Meeting Mobile App Trainee Professional Development Awards
Research Award in Neuroscience,
Peter and Patricia Gruber Lecture
Lundbeck
Short Course (partial support)
Houston Methodist Neurological Institute
Bruker
Annual Meeting Mobile App, Charging Stations Precisionary Instruments
Annual Meeting Mobile App MilliporeSigma Neuroscience Extra!
Meet-the-Expert Sessions
Nancy Rutledge
Zahniser Fund
Nancy Rutledge Zahniser Fund Friends of SfN Fund
Janssen Research & Development, LLC Nancy Rutledge Zahniser Trainee and SfN Memorial Fund
Burroughs Wellcome Fund Presidential Special Lecture Professional Development Awards Trainee Professional Development Awards
Trainee Professional Development Awards
The Journal of Neuroscience
International Fellows, Diversity Fellows,
National Institute on Drug Abuse
Trainee Professional Development Awardee Professional Development Workshop The Swartz Foundation
The Dana Foundation Poster Sessions Swartz Prize for Theoretical and
Science Educator Award
Computational Neuroscience
John Simpson, PhD
John Simpson, PhD
Trainee Professional Development
Awards, Latin America Training Thorlabs
Program Challenge Grant Meet-the-Expert Session
National Institute of Neurological
Disorders and Stroke
Elsevier Neurobiology of Disease Workshop, The Trubatch Family
Dialogues Between Neuroscience Neuroscience Scholars Program
The Trubatch Family
and Society Lecture, Annual Meeting The Kavli Foundation Janett Rosenberg Trubatch
Mobile App Fred Kavli History of Career Development Awards
Neuroscience Lecture
The Waletzky Award
Improving Health
Advancing Science
Prize Fund and the
eNeuro NATIONAL PRIMATE Waletzky Family
RESEARCH CENTERS
International Fellows, Diversity Fellows, NPRCresearch.org
The Waletzky Award Prize Fund
Trainee Professional Development David Kopf Instruments National Primate Research Centers and The Waletzky Family
Awardee Poster Sessions David Kopf Lecture on Neuroethics Animals in Research Panel Jacob P. Waletzky Award
Sustaining Associate Members
The Society for Neuroscience gratefully acknowledges the generous support of its Sustaining Associate Members:
Platinum Gold Silver Nonprofit
Carl Zeiss Microscopy, LLC Elsevier Charles River Grete Lundbeck European Brain
Research Foundation
Olympus America Inc. Nikon Instruments Inc.
National Institute on Drug Abuse
Sutter Instruments
6 | NEUROSCIE NCE 2 016
SfN’S ONLINE CAREER CENTER
Career Center
Saturday, Oct. 17–Tuesday, Oct. 20, 8 a.m.– 5 p.m.
Wednesday, Oct. 21, 8 a.m.– 3 p.m.
The premier resource for Neuroscience Jobs,
Access tools for posting jobs, searching
resumes, scheduling interviews, connecting with
employers, and message services.
NeuroJobs.sfn.org
The Society for Neuroscience gratefully acknowledges the Ralph Adams Pierre Morell
Janel Beckman Robert Muller
generous contributions made in the past year in memory of the Shlomo Bentin David Olton
following individuals through the Adrian James Bower Richard K. Orkand
Roland Ciaranello George D. Pappas
John W. Daly Itzhak Parnas
SfN Memorial Fund
Oscar Diez-Martinez Larry Parsons
Allison Doupe S. Kaleem Quadri
Thomas Dunwiddie Raniyah Ramadan
Gerald M. Edelman Ferdinando Rossi
Augusto Fernandez Randall Sakai
Marie T. Filbin Miriam Salpeter
The SfN Memorial Fund supports the Society’s mission of providing Karen Gale Fred Samson
Peter A. Getting Yoshiki Sasai
professional development activities and educational resources for Patricia Goldman-Rakic Toni Shippenberg
Menek Goldstein Louis Sokoloff
neuroscientists at all stages of their careers. To inquire about specific initiatives William Greenough Eliot Stellar
Steve Heinemann Lisa Stefanacci
or to make a tax-deductible donation, visit SfN.org/supportsfn or e-mail
Elwood Henneman Richard C. Thompson
George Hess Case Vanderwolf
development@sfn.org.
Margaret A. Hollyday Joshua Wallman
Colin Ingram Norman M. Weinberger
Ann E. Kelley Richard E. Whalen
James Kew William D. Willis
Irving Kupfermann Jeffery A. Winer
Edward H. Lambert Franziska Wollnik
J. David Leander Christi J. Wylie
Xu Liu Nancy Rutledge Zahniser
7 | NEUROSCIE NCE 2 016
SCIENTIFIC CONTENT
8 Program at a Glance 24 Workshops, Meetings, and Events 39 List of Sessions by Theme and Day
12 Featured Lectures 32 SfN‑Sponsored Socials 62 Clinician-Scientists and Continuing
Medical Education
14 Special Lectures 35 Satellite Events and Non‑SfN Socials
63 Awards in Neuroscience
16 Symposia
20 Minisymposia
8 | NEUROSCIE NCE 2 016
Program at a Glance
Creating, Sustaining, and Enhancing
Friday, November 11 Undergraduate Neuroscience
noon–2 p.m.
Programs (p.28)
Organizer: Janet Finlay, PhD
NEUROBIOLOGY OF DISE ASE WORKSHOP
From Pediatric Encephalopathy to 1–3 p.m. Graduate School Fair (p.28)
8 a.m.–5 p.m. Alzheimer’s: Linking Mitochondria to
Neurological Diseases (p.24) 1–5 p.m. Posters/Nanosymposia
Organizers: Giovanni Manfredi, MD, PhD; Heidi McBride, PhD
1:30–4 p.m. Symposia/Minisymposia CME
SHORT COURSE # 2 SPECIAL LECTURE
Data Science and Data Skills for Lineage Analyses of Developing
8 a.m.–6 p.m. 2–3:10 p.m.
Neuroscientists (p.24) CNS Tissues CME (p.14)
Organizers: Alyson Fletcher, PhD; Konrad Kording, PhD Lecturer: Connie Cepko, PhD
BR AIN AWARENESS CAMPAIGN EVENT
SHORT COURSE #1
3–4:30 p.m. Sharing the Magic of Brain Awareness (p.28)
Using Single-Cell Genomics To Analyze
8:30 a.m.–6 p.m. Speaker: Susana Martinez-Conde, PhD
Neurons, Glia, and Circuits (p.24)
Organizer: Steve McCarroll, PhD
Biomedical Education and Career Options
for Scientists (PhD) and Physician–
3–5 p.m.
Scientists (MD, PhD) (p.28)
SHORT COURSE # 3 Organizer: Lique Coolen, PhD
Record Keeping and Data Management
1–5:30 p.m. for High-Quality Science (p.25) NIH Funding and You: A Practical Guide
Organizers: Michele Basso, PhD; Katja Brose, PhD; Horacio to Successfully Navigating Your Research
3–5 p.m.
de la Iglesia, PhD; Sabine Kastner, MD, PhD; Rae Nishi, PhD Training Career (p.28)
Organizer: Stephen Korn, PhD
PRESIDENTIAL SPECIAL LECTURE
Saturday, November 12 5:15–6:25 p.m.
Tuning Auditory Circuits for Vocal
Communication CME (p.12)
8–9:15 a.m. Meet‑the‑Clinician-Expert (p.25) Speaker: Sarah M. N. Woolley, PhD
8–9:15 a.m. Meet‑the‑Expert Series: Session 1 (p.25) 6:30–8:30 p.m. Diversity Fellows Poster Session (p.28)
8 a.m.–5 p.m. NeuroJobs Career Center (p.27)
6:30–8:30 p.m. International Fellows Poster Session (p.28)
Neuroscience Departments and
Trainee Professional Development Awards
9–11 a.m. Programs Workshop (p.27) 6:30–8:30 p.m.
Poster Session (p.29)
Organizer: Elisabeth Van Bockstaele, PhD
Success in Academia: A Focus on Career Development Topics:
9–11 a.m. Strategies for Women (p.27) 7:30–9:30 p.m.
A Networking Event (p.29)
Organizer: Tracy Bale, PhD
9:30–10:45 a.m. Meet-the-Expert Series: Session 2 (p.26)
Sunday, November 13
10–11 a.m. Meeting Mobile App Tutorial (p.27)
8 a.m.–noon Posters/Nanosymposia
DIALOGUES BET WEEN NEUROSCIENCE
AND SOCIET Y 8 a.m.–5 p.m. NeuroJobs Career Center (p.27)
11 a.m.–1 p.m. Global Mental Health and Neuroscience:
Challenges and Opportunities (p.13)
Speaker: Shekhar Saxena, MD SPECIAL LECTURE
Bitten: Understanding and Modulating
8:30–9:40 a.m.
Mosquito Attraction to Humans CME (p.15)
Careers in Making Medicines:
Speaker: Leslie B. Vosshall, PhD
Translating Basic Research Into
noon–2 p.m.
Pharmaceutical Development (p.27)
Organizer: Fiona Randall, PhD 8:30–11 a.m. Symposia/Minisymposia CME
Download the meeting mobile app for up-to-date session information
9 | NEUROSCIE NCE 2 016
A Guide to Publishing in Journals (p.29)
9–11 a.m. SOCIAL ISSUES ROUNDTABLE
Organizer: Ross Hildrew
Concussion: From the Players’ Experience
1–3 p.m.
to the Future of Research (p.29)
Stand Up and Be Heard: Navigating Career Organizer: Candace Floyd, PhD
9–11 a.m. Communications (p.29)
Organizer: Fiona Randall, PhD
1–5 p.m. Posters/Nanosymposia
9:30 a.m.–5 p.m. Exhibits (p.90)
1:30–4 p.m. Symposia/Minisymposia CME
SPECIAL LECTURE PETER AND PATRICIA GRUBER LECTURE
Dendritic Spines Shaping Memory and 2:30–3:40 p.m. Random Walk in Neurobiology (p.12)
10–11:10 a.m. Speaker: Mu–ming Poo, PhD
Behaviors CME (p.15)
Speaker: Haruo Kasai, MD, PhD
Meeting Expectations: NIH Review Criteria
on Scientific Rigor and Reproducibility
3–5 p.m.
(p.30)
SPECIAL LECTURE Organizer: Cheryl Sisk, PhD
Translational Neuroepigenetic Insights of
11:30 a.m.–12:40 p.m.
Addiction Vulnerability CME (p.15) Optimizing the Mentor-Trainee
Speaker: Yasmin L. Hurd, PhD 3–5 p.m. Relationship (p.30)
Organizer: Lique Coolen, PhD
CHAPTERS WORKSHOP
PRESIDENTIAL SPECIAL LECTURE
Utilizing Chapters to Teach Innovative
11:30 a.m.–1 p.m. Limitations on Visual Development:
Science to Broad Audiences (p.29) 5:15–6:25 p.m.
Neurons and Behavior CME (p.12)
Organizers: Tanea Reed, PhD; Jennifer Yates, PhD
Speaker: Lynne Kiorpes, PhD
Successful Career Advancement Through 6:45–8:45 p.m. SfN-Sponsored Socials
noon–1:30 p.m. Networking: Is It Who You Know? (p.29)
Organizers: Mark Baxter, PhD; Rebecca Shansky, PhD Monday, November 14
noon–2 p.m. Graduate School Fair (p.28) 8 a.m.–noon Posters/Nanosymposia
Path to Translation for the Inspired (p.29) 8 a.m.–5 p.m. NeuroJobs Career Center (p.27)
noon–2:15 p.m.
Organizers: William Mobley, MD; Hao Wang, PhD
SPECIAL LECTURE
SPECIAL LECTURE Quantal Release and Its
8:30–9:40 a.m.
1–2:10 p.m. Circuits for Movement CME (p.14) Requirements CME (p.14)
Speaker: Silvia Arber, PhD Speaker: Robert Edwards, MD
CME This activity has been approved for AMA PRA Category 1 Credit ™. For details, see page 62 and visit SfN.org/cme.
10 | N E U R O S C I E N C E 2 0 16
Program at a Glance
CLINICAL ROUNDTABLE #1 6:45–8:45 p.m. SfN-Sponsored Socials
NEW The Subcortical Source of
8:30–11 a.m.
Inflammatory Malaise CME (p.30)
Organizer: Andrew H. Miller, MD Tuesday, November 15
8 a.m.–noon Posters/Nanosymposia
8:30–11 a.m. Symposia/Minisymposia CME
8 a.m.–5 p.m. NeuroJobs Career Center (p.27)
How to Present Science Using Visual
9–11 a.m. Tools (p.30)
Organizer: Scott Thompson, PhD SPECIAL LECTURE
Genetic Dissection of Sensorimotor
8:30–9:40 a.m.
Circuits in the Spinal Cord CME (p.14)
Teaching Neuroscience With
Speaker: Martyn D. Goulding, PhD
9–11 a.m. Big Data (p.30)
Organizers: William Grisham, PhD; Richard Olivo, PhD
CLINICAL ROUNDTABLE # 2
9:30 a.m.–5 p.m. Exhibits (p.90) NEW Medications Development for
Cannabis Use Disorder: CB1 Receptor
8:30–11 a.m.
Agonists, Antagonists and Signaling-
DAVID KOPF LECTURE ON NEUROETHICS Specific Inhibitors CME (p.31)
Reforming Forensic Science: Some Organizer: Margaret Haney, PhD
10–11:10 a.m. Insights From Research on Vision and
Memory (p.12) 8:30–11 a.m. Symposia/Minisymposia CME
Speaker: Thomas D. Albright, PhD
9:30 a.m.–5 p.m. Exhibits (p.90)
SPECIAL LECTURE SPECIAL LECTURE
Understanding Mammalian Microcircuits: From Song to Synapse:
11:30 a.m.–12:40 p.m. 10–11:10 a.m. Vocal Communication in Sparrows,
Let Inspiration Guide the Way CME (p.15)
Speaker: Jack L. Feldman, PhD Finches, and Mice CME (p.15)
Speaker: Richard D. Mooney, PhD
noon–2 p.m. Graduate School Fair (p.28)
ANIMALS IN RESE ARCH PANEL
How to Engage Institutions to Publicly
It’s a Win-Win: Effectively Engaging 10 a.m.–noon Support Animal Research: A Top-Down
noon–2 p.m. Undergraduates in Research (p.31) Approach (p.31)
Organizer: Donita Robinson, PhD Organizer: Mar Sanchez, PhD
1–5 p.m. Posters/Nanosymposia SPECIAL LECTURE
Clinical Neuroscience Lecture: Deciphering
1:30–4 p.m. Symposia/Minisymposia CME 11:30 a.m.–12:40 p.m. the Dynamics of the Unconscious Brain
Under General Anesthesia CME (p.15)
Speaker: Emery N. Brown, MD, PhD
ALBERT AND ELLEN GR ASS LECTURE
Natural Products as Probes of the Pain
Celebration of Women in Neuroscience
3:15–4:25 p.m. Pathway: From Physiology to Atomic
noon–2 p.m. Luncheon (p.31)
Structure CME (p.12)
Speaker: M. Victoria Puig, PhD
Speaker: David J. Julius, PhD
noon–2 p.m. Graduate School Fair (p.28)
PRESIDENTIAL SPECIAL LECTURE
Toward Whole-Body Connectome in SPECIAL LECTURE
5:15–6:25 p.m.
Drosophila CME (p.12) 1–2:10 p.m. Cortical Circuits of Vision CME (p.14)
Speaker: Ann-Shyn Chiang, PhD Speaker: Massimo Scanziani, PhD
Download the meeting mobile app for up-to-date session information11 | N E U R O S C I E N C E 2 0 1 6
1–5 p.m. Posters/Nanosymposia
SPECIAL LECTURE
1:30–4 p.m. Symposia/Minisymposia CME Regulation of Neural Stem Cell Fate During
8:30–9:40 a.m.
Development and in the Adult CME (p.14)
Speaker: Yukiko Gotoh, PhD
FRED K AVLI HISTORY OF NEUROSCIENCE
LECTURE
Sixty Years of Research on Neurotransmitter
2:30–3:40 p.m. CLINICAL ROUNDTABLE # 3
Release in the Light of Recent Results from
the Calyx of Held Synapse (p.13) NEW Critical Topics in Pain Mechanisms
8:30–11 a.m.
Speaker: Erwin Neher, PhD and Therapeutics CME (p.31)
Organizer: Timothy J. Brennan, MD, PhD
PUBLIC ADVOCACY FORUM
Art, Music, and the Brain: How the Arts 8:30–11 a.m. Symposia/Minisymposia CME
3–5 p.m.
Influence Us from Youth to Maturity (p.30)
Organizer: William Martin, PhD 9:30 a.m.–5 p.m. Exhibits (p.90)
PRESIDENTIAL SPECIAL LECTURE SPECIAL LECTURE
Neurobiology of the Adolescent and Young Postdiction and Perceptual Awareness
10–11:10 a.m.
Adult Brain Reveals Unique Strengths CME (p.14)
5:15–6:25 p.m.
and Vulnerabilities: Debunking Myths Lecturer: Shinsuke Shimojo, PhD
CME (p.13)
Lecturer: Frances E. Jensen, MD SPECIAL LECTURE
The Social Brain in Human
11:30 a.m.–12:40 p.m.
6:45–7:30 p.m. SfN Members’ Business Meeting (p.31) Adolescence CME (p.15)
Lecturer: Sarah–Jayne Blakemore, PhD
6:45–8:45 p.m. SfN‑Sponsored Socials
SPECIAL LECTURE
9 p.m.–midnight Graduate Student Reception (p.31) Capturing Immune Responses to
1–2:10 p.m. Understand and Treat Neurodegenerative
Disease CME (p.14)
Wednesday, November 16 Lecturer: Eliezer Masliah, MD
8 a.m.–noon Posters/Nanosymposia
1–5 p.m. Posters/Nanosymposia
8 a.m.–3 p.m. NeuroJobs Career Center (p.27) 1:30–4 p.m. Symposia/Minisymposia CME
CME This activity has been approved for AMA PRA Category 1 Credit ™. For details, see page 62 and visit SfN.org/cme.12 | N E U R O S C I E N C E 2 0 16
Featured Lectures
All lectures will take place in Ballroom 20 of the San Diego Convention Center. Overflow viewing will be available in Hall A.
PRESIDENTIAL SPECIAL LECTURE PRESIDENTIAL SPECIAL LECTURE
Circuits for Vocal Communication CME Limitations on Visual Development:
Neurons and Behavior CME
Sarah M. N. Woolley, PhD
Columbia University Lynne Kiorpes, PhD
Support contributed by Biogen New York University
Saturday, November 12, 5:15–6:25 p.m. Sunday, November 13,
5:15–6:25 p.m.
Social communication reflects
the coordinated development Vision develops over
of sensory and motor circuits around signals many months in primate infants. The neural
that convey information. The young brain, mechanisms that limit visual function are not
learning to communicate with hearing and voice, fully understood. During development, neurons
builds auditory and vocal motor circuits that are in the visual cortex are more sensitive than
functionally coupled to perceive and produce would be expected based on visual behavior.
similar signals. This lecture describes progress Abnormal early experience creates a specific ALBERT AND ELLEN GRASS LECTURE
made using songbirds to understand how disorder — amblyopia — which permanently Natural Products as Probes of the
species’ identity dictates the capacities and limits disrupts vision. Here also, the sensitivity of Pain Pathway: From Physiology to
of vocal learning, how early experience shapes neurons in the visual cortex exceeds behavior. Atomic Structure CME
auditory and vocal circuits, and how species and This talk will describe the neural limits on normal
David J. Julius, PhD
learning combine to map auditory tuning onto and abnormal postnatal visual development
University of California,
vocal acoustics. based on studies of the brain and behavior in
San Francisco
human and nonhuman primates.
PETER AND PATRICIA GRUBER LECTURE Support contributed by
Random Walk in Neurobiology DAVID KOPF LECTURE ON NEUROETHICS The Grass Foundation
Reforming Forensic Science: Monday, November 14, 3:15–4:25 p.m.
Mu-ming Poo, PhD
Some Insights from Research
University of California-Berkeley The study of somatosensation, nociception,
on Vision and Memory
and Institute of Neuroscience, and pain has undergone a revolution with the
Chinese Academy of Science Thomas D. Albright, PhD application of molecular genetic, biochemical,
Support contributed by Salk Institute for Biological Studies and biophysical methods. With these
The Gruber Foundation Support contributed by approaches, investigators have begun to identify
Sunday, November 13, 2:30–3:40 p.m. David Kopf Instruments molecules, cells, and circuits that underlie
Monday, November 14, 10–11:10 a.m. stimulus detection, perception, and maladaptive
Beginning as a biophysicist studying diffusion
processes. Together, these studies are providing
of membrane proteins, I stumbled upon many In its 2009 report, Strengthening Forensic Science
an intellectual and technical foundation for
interesting problems in cellular neurobiology, in the United States: A Path Forward, the National
developing new classes of analgesic agents.
including neuronal polarization, axon guidance, Academy of Sciences identified a number of
synaptogenesis, and synaptic plasticity. An significant weaknesses in forensic science, which PRESIDENTIAL SPECIAL LECTURE
underlying theme in all these processes is have contributed to wrongful convictions and have Toward Whole-Body Connectome in
random diffusion of proteins confined or even threatened public confidence in our criminal justice Drosophila CME
directed by localization mechanisms, leading to system. These problems have prompted broad
Ann-Shyn Chiang, PhD
cellular topography critical for neuronal functions. calls for reform of the processes by which forensic
National Tsing Hua
As it turned out, my own career path resembled a evidence is acquired, analyzed, and interpreted.
University, Taiwan
random walk, influenced and sometimes directed Several types of forensic analyses involve
Support contributed by Janssen
by interactions with my students, postdocs, evaluation of complex visual patterns or memories
Research & Development LLC
and colleagues. of visual experiences. Advances in understanding
Monday, November 14, 5:15–6:25 p.m.
of brain systems for visual sensation, perception,
and memory can help shape forensic reform by Our brains receive information from sensory
illuminating the relevant sensory and cognitive neurons about our external environment and
processes, their limitations, and factors that can internal organs. To understand how the brain
improve human performance in a forensic context. processes information and initiates motor
outputs, scientists are constructing complete
Download the meeting mobile app for up-to-date session information13 | N E U R O S C I E N C E 2 0 16
wiring diagrams called “connectomes” that PRESIDENTIAL SPECIAL LECTURE
map all neural connections in the brain and Neurobiology of the
body. Taking Drosophila melanogaster as an and Young Adult Brain Reveals
example, this lecture will address challenges Unique Strengths and Vulnerabilities:
in building whole-body connectomes and how Debunking Myths CME
that knowledge may help us better understand
Frances E. Jensen, MD
normal function and treat disease.
Perelman School of Medicine,
FRED K AVLI HISTORY OF NEUROSCIENCE LECTURE University of Pennsylvania
Sixty Years of Research on Tuesday, November 15, 5:15–6:25 p.m.
Neurotransmitter Release in
Experimental and human
the Light of Recent Results
evidence reveal that
from the Calyx of Held Synapse
adolescence is a paradoxical state, with
Erwin Neher, PhD enhanced synaptic plasticity yet incomplete DIALOGUES BETWEEN NEUROSCIENCE AND SOCIETY
Max Planck Institute for myelination and regional connectivity. Full Global Mental Health and Neuroscience:
Biophysical Chemistry maturity is not reached until the third decade. Challenges and Opportunities
Support contributed by Adolescent brain neuroscience impacts our
Shekhar Saxena, MD
The Kavli Foundation understanding of patterns of onset of psychiatric
World Health Organization
Tuesday, November 15, 2:30–3:40 p.m. illness, the long-term effects of exposure to
Support contributed
substances of abuse and stress, and also
In the 1950s, Sir Bernhard Katz and co-workers by Elsevier
explains their advantage in learning and memory,
laid the foundation for our present understanding Saturday, November 12,
and why they exhibit “signature” behaviors such
of neurotransmitter release and its short-term 11 a.m.–1 p.m.
as impulsivity, emotional liability, altered sleep
plasticity. Their terms “units available” (for release)
cycle, and susceptibility Global mental health is slowly but steadily
and “units responding to one impulse” have been
to addiction. coming out of the shadows. It is benefiting
replaced with terms like vesicle pools, release
from advances in neuroscience, but not
probability, and quantal content. Since then,
adequately. The potential is much greater. This
the description of certain aspects of short-term
lecture will present a background of the current
plasticity has gained considerable complexity.
state of mental health in the world and then
Research on the Calyx of Held has described
focus on how a closer collaboration between
this complexity including heterogeneity of vesicle
mental health and neuroscience could
pools, refractoriness of release sites, and a
enhance knowledge and improve population
phenomenon called “superpriming.” Nevertheless,
health. Examples from the areas of autism,
this talk will argue that the original Katz view is still
substance dependence, psychoses, and
a useful framework on which to build.
dementia will help illustrate this potential.
CME This activity has been approved for AMA PRA Category 1 Credit ™. For details, see page 62 and visit SfN.org/cme.14 | N E U R O S C I E N C E 2 0 1 6
Special Lectures
All lectures will take place in Ballroom 20 of the San Diego Convention Center. Overflow viewing will be available in Hall A
THEME A: DEVELOPMENT vesicles that influence their function, and the THEME D: SENSORY SYSTEMS
Lineage Analyses of Developing CNS implications for synaptic transmission, including Genetic Dissection of Sensorimotor
Tissues CME quantal size, non-vesicular efflux, synaptic vesicle Circuits in the Spinal Cord CME
pools and transmitter co-release.
Connie Cepko, PhD Martyn D. Goulding, PhD
Harvard Medical School and Howard Cortical Circuits of Vision CME Salk Institute for Biological Studies
Hughes Medical Institute Tuesday, November 15, 8:30–9:40 a.m.
Massimo Scanziani, PhD
Saturday, November 12, 2–3:10 p.m.
University of California, San Francisco Sensorimotor circuits in the spinal
Lineage analyses describe the progenitor: progeny Tuesday, November 15, 1–2:10 p.m. cord play essential roles in somatosensation
relationships in developing tissue. Lineage data and motor control. Studies defining the genetic
The diversity of neuron types and
can rule in, or out, particular models of how a cell programs controlling spinal cord development
synaptic connectivity patterns in the cerebral
achieves its fate, as well as when some of the have opened up new avenues for exploring
cortex is astonishing. How this cellular and
fate-determining events occur. Lineages can be the cellular and functional organization of these
synaptic diversity contributes to cortical function
most definitively tracked using clonal methods, as circuits. This lecture will outline our current
is just beginning to emerge. Using the mouse
afforded by retroviral infection. The interpretability understanding of the spinal CPG circuits
visual system as an experimental model, this
of lineage data is further strengthened when that control locomotion and the dorsal horn
lecture will discuss the mechanisms by which
mapping is done from identified types of progenitor pathways that process and transmit cutaneous
excitatory and inhibitory interactions among
cells. Recent studies using such methods in the somatosensory modalities, highlighting the cutting-
distinct neuron types contribute to the most
retina and telencephalon will be presented. edge genetic and behavioral approaches that are
basic operations in visual cortex. This lecture will
being employed to map these circuits.
Regulation of Neural Stem Cell Fate highlight how a functional and structural analysis
During Development and in the Adult CME of cortical circuits allows us to bridge the gap Postdiction and Perceptual
between system and cellular neuroscience. Awareness CME
Yukiko Gotoh, PhD
University of Tokyo THEME C: NEURODEGENERATIVE Shinsuke Shimojo, PhD
Wednesday, November 16, 8:30–9:40 a.m. DISORDERS AND INJURY California Institute of Technology
Capturing Immune Responses Wednesday, November 16, 10–11:10 a.m.
This lecture will discuss how
to Understand and Treat
neocortical neural stem/progenitor cell (NPC) fate There are a few postdictive
Neurodegenerative Disease CME
is regulated in a developmental stage-dependent perceptual phenomena known where a
manner. This lecture will also focus on the Eliezer Masliah, MD stimulus presented later causally affects the
mechanisms underlying long-term maintenance University of California, San Diego percept of target presented earlier. While
of adult neural stem cells (NSCs), the differences Wednesday, November 16, 1–2:10 p.m. backward masking and apparent motion
between embryonic NPCs and adult NSCs, and provide classical examples, the flash lag effect
Neurodegenerative disorders
the embryonic origin of adult NSCs. and its variations have stimulated theorists.
are characterized by progressive accumulation
The TMS-triggered scotoma and its “backward
THEME B: NEURAL EXCITABILITY, of proteins leading to cognitive impairment
filling-in” offer a unique neurophysiological
SYNAPSES, AND GLIA and movement disorders. A dysequilibrium
case. Findings suggest that various visual
Quantal Release and Its Requirements CME in the rate of aggregation, clearance, and
attributes are postdictively reorganized;
synthesis appears to play a key role. Moreover,
Robert Edwards, MD its neural correlates (such as reentry) and
recent studies have shown that prion-like
University of California, San Francisco implications to understand visual awareness
propagation of proteins may contribute to
Monday, November 14, 8:30–9:40 a.m. and sense of agency will be discussed.
neurodegeneration. Therefore, developing
Quantal release by strategies to increase clearance and diminish THEME E : MOTOR SYSTEMS
exocytosis requires the transport of classical prion-like propagation might be key to treating Circuits for Movement CME
neurotransmitters into secretory vesicles. these disorders. Harnessing the power
Silvia Arber, PhD
Vesicular transport activity thus defines the of the immune system by utilizing cellular
Biozentrum, University of Basel and
membranes as well as the cells capable of and humoral immunization has been under
Friedrich Miescher Institute
transmitter release. However, the three families development for the past several years. This
Sunday, November 13, 1–2:10 p.m.
of vesicular transporters differ in ionic coupling. lecture will provide a perspective on the
This lecture will discuss the biophysical properties recent progress and challenges of utilizing Movement is the behavioral output of the nervous
of the transporters, the properties of secretory immunotherapy for neurodegenerative disorders. system. Animals carry out an enormous repertoire
Download the meeting mobile app for up-to-date session information15 | N E U R O S C I E N C E 2 0 16
lecture focuses on the genes and circuits that drive General anesthesia is a drug-induced reversible
this dangerous behavior and how it is modulated by coma. A primary mechanism by which
the internal physiological state of the mosquito. anesthetics induce altered states of arousal is
by producing large, structured oscillations that
From Song to Synapse:
impair communication among brain regions. This
Vocal Communication in
lecture will discuss the neurophysiology of these
Sparrows, Finches, and Mice CME
oscillations and how they change with drug and
Richard D. Mooney, PhD patient age. It will show new ways to control the
Duke University School of Medicine anesthetic state and induce rapid emergence
Tuesday, November 15, 10–11:10 a.m. from anesthesia. Studying mechanisms of
anesthesia is a largely untapped way of studying
of distinct actions, spanning from seemingly simple The interplay between hearing
the brain.
repetitive tasks like walking, to more complex and vocalization is critical to vocal communication
movements such as forelimb manipulation tasks. and vocal learning. Recent research using both The Social Brain in Human
This lecture will focus on recent work elucidating songbirds and mice has provided keen insights Adolescence CME
the organization and function of neuronal circuits at into the neural circuits and mechanisms that
Sarah-Jayne Blakemore, PhD
the core of regulating distinct motor behaviors. It will mediate this sensorimotor interplay. This lecture
University College London
show that dedicated circuit modules within different will cover recent progress in understanding how
Wednesday, November 16,
brainstem nuclei and their interactions in the motor auditory experience engages and shapes motor
11:30 a.m.–12:40 p.m.
system play key roles in action diversification. systems to enable vocal learning, how motor
systems modulate hearing during vocalization Social cognitive processes involved in navigating
Understanding Mammalian Microcircuits:
and other movements, and the neural an increasingly complex social world continue
Let Inspiration Guide the Way CME
circuitry that produces vocalizations used for to develop throughout human adolescence. In
Jack L. Feldman, PhD social communication. the past 20 years, neuroscience research has
University of California, Los Angeles shown that the human brain develops both
THEME G : MOTIVATION AND EMOTION
Monday, November 14, structurally and functionally during adolescence.
Translational Neuroepigenetic Insights of
11:30 a.m.–12:40 p.m. Areas of the social brain undergo significant
Addiction Vulnerability CME
reorganization during the second decade of
More than 25 years since our discovery of the
Yasmin L. Hurd, PhD life, which might reflect a sensitive period for
pre-Bötzinger Complex, the core of the circuit for
Icahn School of Medicine at Mount Sinai adapting to the social environment.
breathing, the underlying mechanisms governing
Sunday, November 13,
its dynamics remain elusive and are much more THEME I : TECHNIQUES
11:30 a.m.–12:40 p.m.
complex than we first thought. This lecture will Dendritic Spines Shaping Memory and
address how novel emergent mechanisms, but not Drug addiction involves complex interaction of Behaviors CME
pacemakers, inhibition, or bursting, are likely to be dynamic processes that contribute to individual
Haruo Kasai, MD, PhD
critical and describe the roles the pre-BötC plays in vulnerability from early stages of development and
Graduate School of Medicine,
regulation of body function, other movements, and during different phases of life by linking genetic
University of Tokyo
emotion. The neural circuit controlling breathing factors with environmental experiences. This lecture
Sunday, November 13, 10–11:10 a.m.
is inimitably tractable and may inspire general will focus on the neurobiological insights recently
strategies for elucidating other neural microcircuits. gained about the molecular underpinnings of Spiny protrusions of dendrite, called dendritic
substance abuse, particularly cannabis and opiates spines, are the major postsynaptic sites
THEME F: INTEGRATIVE PHYSIOLOGY AND BEHAVIOR
using multidisciplinary translational approaches in for excitatory synaptic transmission in the
Bitten: Understanding and Modulating
humans and animal models. The work presented brain. New studies indicate that spines act
Mosquito Attraction to Humans CME
will illuminate epigenetic mechanisms associated as memory elements, and do so by their
Leslie B. Vosshall, PhD with addiction risk that extend even structural plasticity. Such cell motility regulates
Rockefeller University across generations. functional connectivity and enables Hebbian and
Sunday, November 13, 8:30–9:40 a.m. reinforcement learning in the cortex and basal
THEME H : COGNITION
ganglia. Motility can be spontaneous, and such
By the act of feeding on our blood, CLINICAL NEUROSCIENCE LECTURE
fluctuations may determine memory persistence
female mosquitoes spread dangerous infectious Deciphering the Dynamics
and stabilize recurrently connected networks.
diseases such as malaria, dengue, zika, and of the Unconscious Brain
Spine motility connects cell biology to mental
yellow fever to humans. We attract mosquitoes via Under General
functions and disorders.
multiple sensory cues including emitted body odor, Anesthesia CME
body heat, and carbon dioxide in the breath. The Emery N. Brown, MD, PhD
mosquito perceives differences in these cues, both Massachusetts Institute of Technology
between and within species, to determine which Tuesday, November 15,
animal or human to target for blood-feeding. This 11:30 a.m.–12:40 p.m.
CME This activity has been approved for AMA PRA Category 1 Credit ™. For details, see page 62 and visit SfN.org/cme.16 | N E U R O S C I E N C E 2 0 16
Symposia
THEME A: DEVELOPMENT
Neuronal Cytoskeleton 2.0: A Revised
View of an Ancient Edifice CME
Chair: Subhojit Roy, MD, PhD
Co-Chair: Casper Hoogenraad, PhD
Sunday, November 13, 8:30 –11 a.m.
San Diego Convention Center: 6F
The neuronal cytoskeleton is essential for
trafficking molecules into axons and dendrites
and also for maintaining the structural integrity of
these elongated appendages. Recent advances
in super-resolution, live imaging, and genetics
have revealed a remarkable cytoskeletal
organization in neurons, essentially revising
canonical models. The goal of this symposium
will be to inform the audience of these exciting THEME B: NEURAL EXCITABILITY, components mediate synaptic transmission
new developments, present ongoing research, SYNAPSES, AND GLIA and plasticity. This symposium will explore
and foster cross-talk among participants. the ultrastructural and proteinaceous basis
Synaptic Actin Dysregulation:
of synapse function and the defined plasticity
Neuroepigenetics CME A Convergent Mechanism of Mental
states involved in learning and memory.
Chair: Li-Huei Tsai, PhD Disorders? CME
Tuesday, November 15, 8:30 –11 a.m. Chair: Scott H. Soderling, PhD THEME C: NEURODEGENERATIVE
San Diego Convention Center: 6A Co-Chair: Zhen Yan, PhD DISORDERS AND INJURY
Saturday, November 12, 1:30 –4 p.m.
The aim of this symposium is to discuss the role Autophagy-Lysosomal Mechanism in
San Diego Convention Center: 6B
of epigenetic mechanisms of neuronal diversity, Neurodegeneration CME
the plasticity of neuronal networks, and their Synaptic actin polymerization governs activity- Chair: Zhenyu Yue, PhD
alteration during various neurological disorders. dependent modulation of excitatory synapses. Co-Chair: Ana Maria Cuervo, MD, PhD
The symposium will focus on the chromatin-based Many candidate genes for psychiatric and Saturday, November 12, 1:30 –4 p.m.
mechanism of neuronal gene expression regulation, neurodevelopmental disorders encode regulators San Diego Convention Center: 6A
as well as on the epigenetic foundations of memory of signaling to the actin cytoskeleton, suggesting
This symposium will present recent advances
and social behavior, and how pharmacological that its disruption is a commonly affected
in autophagy research in neurons and major
compounds that target specific epigenetic pathway in brain disorders. This symposium
neurodegenerative diseases. It will provide
processes can interfere with diseases. will discuss recent experimental findings that
insight into molecular mechanisms of
strongly support genetic evidence linking the
Making Serotonergic Neurons: autophagy control, particularly on subtypes of
synaptic cytoskeleton to conditions such as
From Mouse to Human CME autophagy that regulate neuronal homeostasis
schizophrenia and autism spectrum disorders.
Chair: Jian Feng, PhD via the clearance of disease protein aggregates
Wednesday, November 16, 1:30 –4 p.m. The Ultrastructural Basis of Synaptic and damaged mitochondria. The session
San Diego Convention Center: 6F Transmission and Plasticity CME will discuss how disease mutants disrupt the
Chair: Kristen M. Harris, PhD autophagy-lysosomal pathway, and strategies
Serotonergic neurons exert diverse actions in the
Co-Chair: Nils Brose, PhD of harnessing neuroprotection of autophagy for
brain. This symposium will highlight how knowledge
Wednesday. November 16, 1:30 –4 p.m. therapeutic development.
on the development of mouse serotonergic
San Diego Convention Center: 6A
neurons informs the strategies to generate human Microtubule and Tau-Based Therapy for
serotonergic neurons by directed differentiation of Since the invention of the electron microscope, Alzheimer’s Disease and Other Brain
pluripotent stem cells or by transdifferentiation of the function of synapses has been illuminated Disorders CME
fibroblasts. The ability to generate patient-specific by ultrastructure. Technological advances Chair: Illana Gozes, PhD
serotonergic neurons opens up unprecedented in stimulation and fixation methods, protein Co-Chair: Eckhard Mandelkow, PhD
opportunities for mechanistic studies and drug identification, and 3-D reconstruction provide Monday, November 14, 8:30 –11 a.m.
discovery in many serotonin-related brain disorders. key insights into how subcellular and molecular San Diego Convention Center: 6A
CME This activity has been approved for AMA PRA Category 1 Credit ™. For details, see page 62 and visit SfN.org/cme.17 | N E U R O S C I E N C E 2 0 1 6
The microtubule subunit, tubulin, is a major development, plasticity, disease, and the injury Chronic pain is a persistent, debilitating
brain protein. Microtubule associated proteins response in the nervous system. condition stemming from a variety of etiologies
like tau are key regulatory elements of neuronal and diseases. Over 1.5 billion people worldwide
THEME D: SENSORY SYSTEMS
and glial health. Microtubule dysfunction suffer from chronic pain that is only partially
leads to the blockade of axonal transport, Neuroscience of Music: Novel alleviated by current therapies and treatments.
glial impairment, and synaptic dysfunction/ Discoveries and Their Implications in the Recent studies have elucidated novel molecular
loss, which are hallmarks of brain diseases. Understanding of Music and the Brain CME and cellular players that drive chronic pain in
This symposium will focus on microtubules in Chair: Elizabeth Stegemöller, PhD animal models and human conditions. This
different cell types for a better understanding of Co-Chair: Patricia Izbicki symposium will review these advances and
brain function in health and disease, and toward Sunday, November 13, 8:30 –11 a.m. discuss their implications for the diagnosis and
improved diagnostics and therapeutics. San Diego Convention Center: 6B treatment of chronic pain patients.
Proteoglycans in Neural Development Recent developments in understanding the Mechanisms of Object Organization in
and Disease CME effects of music on the brain have revolutionized the Visual Cortex CME
Chair: Herbert M. Geller, PhD music therapy, musical neuroeducation, music Chair: Rüdiger von der Heydt, PhD
Co-Chair: Jerry Silver, PhD perception, and music cognition. This symposium Monday, November 14, 1:30 –4 p.m.
Tuesday, November 15, 1:30 –4 p.m. will highlight the neurological mechanisms and San Diego Convention Center: 6F
San Diego Convention Center: 6A significance of music used in the clinical setting,
How does the visual cortex organize elementary
neuroeducation, and daily experiences. Experts
Proteoglycans are secreted by every cell, yet features to objects? This symposium will
in the areas of neuroscience and music will speak
their functions in the nervous system are still provide a comprehensive picture of recent
on topics including music and neuroplasticity,
mostly unexplored. Uniquely, proteoglycans findings on object-based coding at low and
music and neurochemistry, and the biology of
signal through their sugar chains rather than intermediate cortical levels (V1-V2-V4), its
auditory learning.
their protein backbones. These chains are possible mechanisms, and its hypothetical role
heterogeneous in both length and sulfation Current Topics in Chronic Pain: From in vision. The session will also question where
pattern. This symposium will highlight recent Molecules to Medicine CME the organizing influence comes from, how its
developments in identification of receptors Chair: Cheryl L. Stucky, PhD time course is relative to other stages of visual
and signal transduction mechanisms used Co-Chair: Xinzhong Dong, PhD processing, and how the organizing influence
by heparan sulfate and chondroitin sulfate Monday, November 14, 8:30 –11 a.m. relates to object individuation, awareness,
proteoglycans, and how they are involved in San Diego Convention Center: 6B recognition, and selective attention.18 | N E U R O S C I E N C E 2 016
Symposia
THEME E : MOTOR SYSTEMS movement, posture, and locomotor function in control remain poorly understood. This
individuals that have been paralyzed for over symposium will consider this puzzle by
New Developments in Understanding the
one year, a time which historically has been attempting to answer three questions
Complexity of Human Speaking CME
considered beyond the critical period for motor regarding what Purkinje cells and cells at deep
Chair: Kristina Simonyan, MD, PhD
recovery. A subject that has received these cerebellar nuclei encode, what inferior olive
Sunday, November 13, 8:30 –11 a.m.
interventions will share his experiences. neurons that project onto these cells encode,
San Diego Convention Center: 6A
and how Purkinje cells learn to alter their
Spike Timing Codes for Motor Control CME
Speech is one of the most unique features of encoding in response to error information from
Chair: Samuel J. Sober, PhD
human existence and communication. Our the inferior olive.
Tuesday, November 15, 8:30 –11 a.m.
ability to articulate our thoughts depends
San Diego Convention Center: 6F THEME F: INTEGRATIVE PHYSIOLOGY AND BEHAVIOR
critically on the integrity of the motor cortex.
Long thought to be a low-order brain region, Neurons emit spike trains that vary in both the rate Physical Activity Impacting
exciting work in past years is overturning this and precise timing patterns of spikes. Whereas Neuroplasticity in Aging and Disease CME
notion. In this symposium, speakers will highlight there is substantial evidence that sensory systems Chair: Giselle Petzinger, MD
major experimental advances in speech motor can use millisecond-scale spike timing patterns Co-Chair: Sarah McEwen, PhD
control research and discuss emerging findings to encode information, studies of motor control Sunday, November 13, 1:30 –4 p.m.
about the complexity of speech motor cortex have focused almost exclusively on spike rates. San Diego Convention Center: 6A
organization and its large-scale networks. This session will present emerging work from a
This symposium will present translational
wide range of species (insects, songbirds, and
Facilitation of Recovery of Motor research investigating physical activity-induced
mice) showing that brains can control behavior by
Function After Paralysis With Non- structural and functional alterations in brain
precisely regulating spike timing patterns.
Invasive Spinal Cord Stimulation CME circuits and synaptic function, and potential
Chair: V. Reggie Edgerton, PhD The Neural Basis of Adaptive Motor mechanisms underlying activity-dependent
Monday, November 14, 1:30 –4 p.m. Control in the Cerebellum CME plasticity in aging and disease. Effects of exercise
San Diego Convention Center: 6A Chair: Reza Shadmehr, PhD on structure and functional connectivity of
Wednesday, November 16, 1:30 –4 p.m. the brain and alterations in gene and protein
This symposium describes changes of the
San Diego Convention Center: 6B expression important for neuroplasticity
physiological state of spinal networks using
will be discussed in the context of aging,
noninvasive spinal cord stimulation combined The cerebellum is critical for learning to
neurodegenerative disorders, and schizophrenia.
with step training in an exoskeleton. The make accurate movements, yet the neural
speakers will demonstrate recovery of voluntary mechanisms of how it learns this adaptive
CME This activity has been approved for AMA PRA Category 1 Credit ™. For details, see page 62 and visit SfN.org/cme.19 | N E U R O S C I E N C E 2 0 16
Getting Down to Business: Identifying processing of reward and aversion. Because
Epigenetic Mechanisms of Behaviors dysfunctions in reward processing have
Within Discrete Cell Populations CME been implicated in psychiatric illnesses and
Chair: Tracy L. Bale, PhD drug abuse, the symposium will increase our
Co-Chair: Paul J. Kenny, PhD mechanistic understanding of how aberrant
Wednesday, November 16, 8:30 –11 a.m. activity in the LHb circuits may contribute to
San Diego Convention Center: 6B these disorders.
Identifying the epigenetic modifications and their Moving From Pavlovian ‘Fear’
impact within discrete neuronal populations Conditioning to Active Avoidance CME
is critical in understanding brain health and Chair: Christopher K. Cain, PhD
disease risk, including behaviors important Co-Chair: Gregory J. Quirk, PhD
to stress coping, addiction, and learning and Tuesday, November 15, 1:30 –4 p.m.
memory. Expert speakers will describe their San Diego Convention Center: 6B
THEME H : COGNITION
latest studies on novel epigenetic mechanisms,
In the active avoidance paradigm (AA), subjects
including miRNAs, nucleosome remodeling, and Is the Prefrontal Cortex Special?
learn to emit actions that escape threats
unique histone modifications, and demonstrate Working Memory Across the Cortical
and prevent harm. AA research stalled in the
their role in specific behavioral outcomes. Mantle: From Single Units to Neural
1970s, partly because psychologists disagreed
Ensembles CME
THEME G : MOTIVATION AND EMOTION intensely over the reinforcement mechanisms
Chair: Julio C. Martinez-Trujillo, MD, PhD
and nature of avoidance responding (operant
Advances in Noninvasive Brain Co-Chair: Christos Constantinidis, PhD
vs. respondent). However, recent work has
Stimulation Along the Space-Time Saturday, November 12, 1:30 –4 p.m.
shed new light on the distinction between
Continuum CME San Diego Convention Center: 6F
AA and fear conditioning brain circuits. This
Chair: C. Alex Goddard, PhD
session will detail this progress and discuss the Working memory (WM) is one of the pillars
Co-Chair: Sarah H. Lisanby, MD
role of AA in human anxiety disorders such as of cognition. This symposium will offer an
Monday, November 14, 1:30 –4 p.m.
obsessive-compulsive disorder. updated view of WM coding in primates, with
San Diego Convention Center: 6B
emphasis in the prefrontal cortex. Experts will
Neural Basis of Social Rewards and
Noninvasive brain stimulation (NBS) is a key discuss WM coding in different brain areas of
Group Decisions: From Scanners to the
tool for probing neural circuit function and is macaques, how the macaque prefrontal cortex
Real World CME
being tested to ameliorate a host of neurological encodes WM across the life span, how the
Chair: Brian Knutson, PhD
and psychiatric conditions. Recent studies prefrontal cortex integrates WMs from different
Co-Chair: Jorge Moll, MD, PhD
suggest that specific spatial and temporal modalities, and how to bridge WM studies in
Wendesday, November 16, 8:30 –11 a.m.
NBS parameters are critical for achieving macaques and humans.
San Diego Convention Center: 6A
effective modulation of intact neural circuitry.
Fronto-Subthalamic Circuits for Control
This symposium will highlight several studies Neuroimaging has dramatically improved
of Action and Cognition CME
that explore the importance and physiological our understanding of the neurobehavioral
Chair: Adam R. Aron, PhD
relevance of specific spatial or temporal patterns systems that support social cognition and
Monday, November 14, 8:30 –11 a.m.
using different forms of NBS. choice. This symposium will highlight new
San Diego Convention Center: 6F
advances, focusing on the role of reward and
The Lateral Habenula Circuitry: Reward
motivation in social perception, interpersonal This session will report new findings about
Processing and Cognitive Control CME
communication, intergroup relations, and the cognitive functions and computational
Chair: Aleksandra Vicentic, PhD
mass prosocial behavior. Speakers will also properties of the circuit linking frontal cortex
Co-Chair: Bo Li, PhD
describe novel techniques and trends poised and subthalamic nucleus (STN) of the basal
Tuesday, November 15, 8:30 –11 a.m.
to extend the frontiers of neuroscience and ganglia. Diverse and novel technical approaches
San Diego Convention Center: 6B
account for social preferences and behaviors in humans are taken to record cortical and STN
This symposium will present novel concepts in naturalistic settings. electrophysiology at the same time, to record
from animal studies of the lateral habenula single-unit human STN activity, to use 7T fMRI,
that have been recently tested with causal and to stimulate STN optogenetically in mice.
methods, with a goal to dissect the role of The role of the circuit is highlighted for stopping
specific inputs and outputs of the LHb in and pausing behavior and cognition.You can also read
