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PAUL O’GORMAN
PAUL O’GORMAN NEWSLETTER WINTER 2020
FOR ALUMNI AND FRIENDS OF THE
UNIVERSITY OF GLASGOW
LEUKAEMIA
WORLD
RESEARCH
CHANGING
GLASGOW
CENTRE
University of Glasgow charity number SC004401
The University of Glasgow Trust, charity number SC008303PAUL The Paul O’Gorman Leukaemia Research UPDATE FROM
O’GORMAN Centre is part of the University of Glasgow’s
DIRECTOR
LEUKAEMIA Institute of Cancer Sciences. The Centre was
MHAIRI COPLAND
RESEARCH NOVEMBER 2020
officially opened on the 22nd of May 2008 by
CENTRE
Dr Richard Rockefeller.
2020 has been a strange
It was built after a The facility is state of the art and
fundraising drive by the incorporates the latest research and often difficult year for
technologies required to perform
University of Glasgow basic, translational and clinical most people. We have
in collaboration with Our aim is to perform
Leukaemia & Lymphoma
research. The Centre also benefits
from close interactions with the basic research
all had to adapt our lives,
Research (now Blood Beatson Institute for Cancer to identify novel our way of working, and
Cancer UK), which saw Research and clinical departments therapeutic targets for
more than £2.6million raised
of the Beatson West of Scotland
leukaemia and translate
adjust to limited socialising
Cancer Centre.
in six years, through the our laboratory findings with family and friends.
The major focus of the Centre is the into new effective
commitment and generosity
haemopoietic (blood) stem cell which
of more than 1800 donors is weakened to cause many different medicines for patients.
and supporters. forms of leukaemia.
This has been particularly However, despite the ongoing
difficult for blood cancer difficulties and uncertainty, we have
seen many highlights at POG over
patients, many of whom the last 12 months. I am delighted
have had to shield and take to let you know that Helen Wheadon
additional precautions since has been promoted to Professor,
March; our thoughts are Vignir Helgason to Reader and
with them. Kristina Kirschner to Lecturer. The
TASTER clinical trial for patients with
Please consider getting
treatment-resistant chronic myeloid involved in one of our
When the first lockdown came along
in March, POG was closed from leukaemia (CML) has opened. We virtual fundraising
end of March until mid-July, with have received in excess of £2 million activities in the coming
many staffed furloughed and some in funding with major grants from months or let us know
going to assist with the fight against Cancer Research UK, Blood Cancer
UK, Cure Leukaemia and MRC.
if you have ideas of
COVID-19 by working in the Glasgow
We have also benefitted from the your own.
Lighthouse Lab. Happily, the lab is
open again, although we continue endowments bequeathed by the late
to operate a shift system in order to Professor Tessa Holyoake and Joan
maintain social distancing, with some Snodgrass, and both these awards
staff continuing to work from home. are benefitting our early career
researchers and PhD students.
Understandably, there has been a Wishing everyone a happy, healthy
huge reduction in the donations we With the hope of a COVID-19 vaccine and peaceful Festive Season.
have received through fundraising now on the horizon, we aim to start
2021 with new ideas and enthusiasm Take care and stay safe
activity, with most 2020 events
cancelled. This has a big impact for both our research and to help
on the research we are able to do,
in terms of funding both staff and
support our fundraisers. I’d like to
thank all our fundraisers for their Mhairi
equipment. We are not alone in this support over the years and look Professor Mhairi Copland
and all Cancer/Leukaemia charities forward to meeting and working with
face similar challenges. you again soon.
2 PAUL O’GORMAN NEWSLETTER WINTER 2020 FOR MORE INFORMATION, VISIT GLASGOW.AC.UK 3STAFF In this section, we asked
World Cancer Day UNDER THE
ACHIEVEMENTS/ (4th February) and Women in MICROSCOPE – two of our scientists at
MEETINGS/ Science Day (11th February)
PROFESSOR HELEN WHEADON & POG to share what part
PRESENTATIONS DR KRISTINA KIRSCHNER of their work entails -
Enhancing Post Single Cell Advanced
Graduate Education Technologies Service
– Professor Helen – Dr Kristina
Wheadon Kirschner
“Since becoming the Associate Dean for “I set up a single cell advanced
Postgraduate Research (PGR) in 2016, technologies service in 2018, aided by
I have played an active role in supporting senior technician Dr. Hsieh.
For World Cancer Day and our students within the College of Medicine, Studying individual cells by using a new technology
Women in Science Day, the Veterinary and Life Sciences (MVLS), this able to characterise gene activity (expression) and the
work of two of our amazing includes (PhD, MD and MSc by Research). presence of mutations (mutational status) in a single cell
researchers, Professor rather than from a collection of cells, as would be the
I have worked with the excellent team at the Graduate case in a blood sample or a tissue biopsy, is an important
Mhairi Copland and Dr Alison School to transform the training and support for MVLS technical development. Single cell approaches are very
Michie was highlighted in PGR students (~688 students). important in cancer research since we know that only a
a *Bloodwise campaign This has involved developing an innovative, diverse and minor group/subpopulation of cells usually causes and
(*now known as Blood Cancer UK) internationally competitive training programme to “up- maintains a disease. Single cell approaches look at single
skill” our students. This training programme includes key cancer cells and try to identify the cancer cell that drives a
life-skills that are needed for career progression in and cancer or helps to evade treatment.
out of academia. I have also helped develop supervisor On the back of setting up the single cell service, I was
training programmes for PhD supervisors and helped awarded the John Goldman Fellowship, where I use
UofG’s Future World Changers: "I am Kudzai Nyamondo and create on-line spaces full of useful information for both single cell technologies to identify markers to detect faulty
I am in the second year of my PhD at the Paul O’Gorman PGR students and supervisors. blood cells before they cause a blood cancer. I hope to
Leukaemia Research Centre under Dr. Helen Wheadon’s
Cohort building has also been at the forefront of the new be using these factors to detect and/or eliminate faulty
supervision. I was recently selected as one of University of
strategy, developing on-line chat rooms and support for blood cells before blood cancer occurs in the future and
Glasgow’s Future World Changers for 2019/2020".
student-led initiatives that bring our various PhD cohorts to improve blood cell function in the elderly.
Using artificial bone marrow niche models generated via tissue together. I have also been instrumental in underpinning Dr. Hsieh successfully applied for a Tessa Holyoake
engineering, I am studying the therapeutic targeting of leukaemic our strategy towards protecting the mental health of PGR Endowment fund to improve our understanding of chronic
stem cells (LSCs) which are responsible for disease persistence in students, introducing “buddy” schemes and training myeloid leukaemia (CML), by using a newly developed
chronic myeloid leukaemia. courses on well-being. Another area I have focused technique called ‘single-cell CITE-seq’. This method
on is Equality, Diversity and Inclusion in the Doctoral provides huge advantages in assessing blood cancers,
Training Programme, aimed at widening and supporting as it looks at gene expression and cell surface markers
participation for minority groups. in each specific cell and their abnormalities, rather than
"My ambition is to transform the This has taken shape through my whilst seeing first-hand how a social COVID has been a particularly challenging time for our looking at the blood in bulk. This project will hopefully
quality of healthcare in developing working with GOVIRAL, which is a enterprise can map out effective students with many students worrying about their families allow us to assess CML before and after treatment and
countries. Whilst advances in social enterprise founded by UofG solutions to address healthcare and research productivity during the ‘lock-down’. To help identify cell surface markers that might indicate resistance
medicine have created several alumna Jiska van der Reest and concerns and navigate existing and reassure our students we provided online drop in to therapy.
solutions currently used in the Ryan Gersava. GOVIRAL aims to political and economic issues. In sessions and developed detailed mitigation plans on how Overall, the single cell service has now aided a large
developed world, there is an evident reduce the prevalence of hepatitis B the long run, my hope is to continue to perform ‘dry’ lab based research, undertake systematic group of researchers in the Institute of Cancer Sciences to
gap in addressing similar issues within the Philippines by increasing identifying sustainable solutions to reviews with on-line learning resources provided. attract funding in excess of £4M”.
in low income countries. My hope awareness, advocacy and access healthcare issues whilst identifying The support we offer as a graduate school has resulted
is to acquire the skills necessary to treatment. Working with GOVIRAL ways to equip individuals within those in excellent completion rates, student satisfaction with
to address the existing healthcare has given me the opportunity to communities with necessary skills to students leaving to pursue rewarding careers in science.
problems. apply some of the scientific skills make a living". Training the next generation of scientists is essential in our
I’m developing through my PhD, quest to understand and treat diseases”
4 PAUL O’GORMAN NEWSLETTER WINTER 2020 FOR MORE INFORMATION, VISIT GLASGOW.AC.UK 5Dr Kristina Kirschner received a Research Centre are pleased to announce
reagent grant from ArcherDX for targeted the development of the Joan Snodgrass
sequencing of clonal haemopoiesis Bequest PhD studentship. This studentship
STAFF NEWS, mutations. will provide a promising science graduate LIGHTHOUSE
GRANTS & LAB
the opportunity to carry out a programme
CR-UK Programme Foundation Award -
of leukaemia research within our state-
Dr Gudmundur Vignir Helgason - Title:
AWARDS “Targeting Autophagy and Aberrant
Metabolism of Leukaemic Stem Cells”.
of-the-art facilities. This year the PhD
studentship was awarded to Dr Alison VOLUNTEERS
Michie’s laboratory whose main research
Currently, leukaemic stem cells in chronic
focus is chronic lymphocytic leukaemia
myeloid leukaemia are resistant to therapy.
(CLL) and PhD student Jamie Lees starts
Our previous work has highlighted two
in January 2021.
cellular processes, autophagy and
mitochondrial metabolism, as critical for Jamie’s PhD is entitled. “Exploiting More than 800
the survival of chronic myeloid leukaemia the role of individual members of the
stem cells. FOXO transcription factor family: do volunteers came
they differentially regulate CLL survival,
The main aims of the CR-UK Programme
proliferation and chemosensitivity?” forward when the
Foundation Award is to further investigate
how we can inhibit these processes
The aim of this Joan Snodgrass funded
project is to elucidate the molecular
Lighthouse Lab in
and test novel drug that we have
identified through drug screening or
mechanisms that regulate individual FOXO Glasgow opened.
Vignir Helgason family members, providing fundamental
obtained through collaboration with
information regarding their regulation in
industry. Award: £1.35M https://www.
cancerresearchuk.org/funding-for-
Chronic Lymphocytic Leukaemia cells, The facility is now staffed
and potentially highlight novel therapeutic on a 24/7 basis by a
Staff Promotions: researchers/our-funding-schemes/
avenues. PIs are Dr Alison Michie and
Many congratulations to Helen Wheadon programme-foundation-awards
Dr Xu Huang.
team of experienced
who has been promoted to Professor of Dr Kristina Kirschner was awarded a scientists, including highly
Joan Snodgrass Bequest - The Joan
Stem Cell Regulation, Vignir Helgason Springboard award from the Academy experienced molecular
Snodgrass Bequest also generated funds
who is now Reader (Translation Research of Medical Sciences – “Elucidating the scientists, technicians
to support a small project, which we are
Centre) and Kristina Kirschner is role of Notch signalling in secondary and bioinformaticians –
delighted to announce was awarded to
promoted to Lecturer. senescence”
Dr. Jodie Hay to investigate the regulation all with the relevant skills
Cure Leukaemia Trials Acceleration of the CLL tumour microenvironment upon and experience to carry out
Programme – Professor Mhairi Copland modulation of FOXO1 activity.
MVLS Service Excellence Awards: COVID-19 testing.
has successfully led the haemato-
Congratulations also to Diane Verrecchia, oncology clinical trials team at the Beatson
Section Administrator at POG on her West of Scotland Cancer Centre in a bid to Other News:
recent MVLS excellent services award. secure funding for a research nurse for 3
Many congratulations to Mike Moles PhD
years to help fast-track early phase clinical
who passed his VIVA recently. Mike’s Three members of staff from POG,
trials in blood cancers. Award: £150,000.
supervisor was Dr Alison Michie and Jennifer Cassels, Jodie Hay and
Grants Awarded:
his PhD entitled “Investigating mTORC2/ Rebecca Mitchell were part of the
Tenovus pilot project grant, co-applicants AKT-mediated regulation of FOXO1: a team working at the Lighthouse
– Dr Xu Huang/Dr Gillian Horne (POG) Endowment Awards: novel therapeutic strategy in chronic lab, testing for COVID-19. We are
Professor Tessa Holyoake Endowment lymphocytic leukaemia?” was funded by proud their transferrable skills are
CSO catalyst project grant, co-applicants
Fund - Dr. Ya-Ching Hsieh (Dr Kristina the Forgie – Friends of Paul O’Gorman being used in this way.
– Dr Xu Huang/Dr Heather Jorgensen
Kirschner’s group) was awarded the PhD studentship. Mike wished to give a
(POG) - “Identification of Combination
Professor Tessa Holyoake Endowment special mention and thank you to Hugh
Therapies Targeting DNA Damage Repair
Fund Small Research Grant 2019 for her “Shuggie” Forgie, for whom this PhD
Signalling Pathways in AML Stem Cells”
project “Single cell transcriptome and studentship was named. Hugh, together
MRC CiC project grant, co-applicants protein BM niche profiling with CITE-seq in with his wife Mags, raised a tremendous
– Dr Xu Huang/Dr Heather Jorgensen amount of money for POG-LRC, by cycling
CML disease progression”. Dr Jodie Hay shares I am the onsite Data Manager and
(POG) - “Target validation of the critical from Glasgow to Malaga, which provided oversee the sample results which
epigenetic regulator, KDM4A in acute Laura Monaghan (Dr Xu Huang’s group) the funding for this PhD studentship her experience at the
leave the lab and are reported to
myeloid leukaemia” has been awarded the Professor Tessa specialising in CLL research. Sadly, Hugh Lighthouse Lab the NHS. I also oversee the data
Holyoake Endowment Small Grant did not quite make it through to see the
Royal Society International Exchange of the national screening studies
Award for 2020. Her successful project finished product, dying peacefully of CLL “I have been seconded to the
Fund, co-applicants – Dr Xu Huang/Prof. and clinical trial samples which are
is titled “Use of SLAM-seq to profile at the Beatson on Saturday 5th September Lighthouse Lab in Glasgow since 6th
Zhi Qi (Peking University, China) processed here in Glasgow. I work
direct transcript changes following 2020. He will be missed by all who knew April. I was one of the first 6 University
with the different Government bodies
MRC CiC Project Grant – Dr Karen pharmacological inhibition of KDM4A in him. Thank you to Hugh, and all the staff to join and helped set up the
and Trial teams closely to manage
Keeshan (POG) - “Developing TRIB2 as human AML cells”. patients who willingly donated samples lab which is now processing 70,000
Jodie Hay these different studies, which has
a predictive biomarker for acute myeloid that contributed to the completion of samples per day.
Joan Snodgrass Bequest - Through the been very exciting to be part of!”
leukaemia sensitivity to the clinical generosity of the late Joan Snodgrass and this PhD.
covalent multi-ERBB compounds” her family, the Paul O’Gorman Leukaemia
6 PAUL O’GORMAN NEWSLETTER WINTER 2020 FOR MORE INFORMATION, VISIT GLASGOW.AC.UK 7LIFE AT THE FUNDRAISING
LAB DURING EVENTS
LOCKDOWN –
STUDENT EXPERIENCES
Fundraising is a huge
Narissa Parry, one of our PhD students working part of life at the Paul
with Professor Mhairi Copland, tells us of her O’Gorman Leukaemia
experience coming back to the lab at POG Research Centre and
plays a vital role in
“Getting back to the POG Along with lab work, an important
after months working from aspect of my PhD has been getting supporting our current
home was a breath of
involved with community outreach
programmes, engaging the public
and future research.
fresh air! With the physical with science, and raising awareness
distancing, face masks and of the fantastic work done at POG. In 2009 a committee made Here are a few of the fabulous
cleaning rotas in place, To this end, this term I have been up of patients, volunteers fundraising events over the past
it didn’t take very long to A WARM 12 months: The fantastic
mentoring S6 students at a local WELCOME TO and donors was established
get back into the swing Glasgow high school as they earn ALL OF OUR Team McGuigan – Final Farewell! fundraising family
to raise awareness
of things. their Young STEM Leader Awards, NEW STAFF. Congratulations and a huge thank raised nearly £6000
and hopefully inspiring the next about the centre and to
you from everyone at POG to John at their recent
At the forefront of all of our minds at generation of cancer scientists! generate funds. & Maureen McGuigan who have charity night – which
POG is how to make our work in the Dr Anand Manoharan joined us as a Research reached an amazing fundraising total
Associate in March 2020. He is working The committee organises a broad had extra special
lab translatable to a real improvement of £90,323 after their final charity
for patients with blood cancer, and with Professor Mhairi Copland and Dr Karen selection of events throughout the night in October 2019. emotional attachment
the time away from the lab gave us Keeshan. Anand has a 12-month project with course of the year. If you would like as this year marked
This year has been a our industrial collaborator Cyclacel exploring to hear more about these events Team McGuigan first began raising
all plenty of time to evaluate where their “final farewell” to
our research currently stands and difficult one, but as the cell cycle and apoptosis in AML. or to join the committee, please money in 2003 by taking part in a
contact Michaella Mitchell, Supporter sponsored cycle, which became an the annual event.
hone experiments needed to make we adapt to our new
Engagement Manager, Development annual family fixture for more than a
our work the best it can be. normal, we’re glad to
be back at the bench POG NEW STARTS & Alumni External Relations - decade.
In the time that we’ve been back, (0)141 330 8501 or email michaella.
I’ve been working on the final few and working to improve PGR – PhD students
mitchell@glasgow.ac.uk
experiments needed to complete the the lives of people with Daniele Sarnello started in October 2020 with
work for my thesis, tying together blood cancer”. Vignir Helgason. Daniele’s PhD studentship
loose ends and confirming various is funded by CRUK and is entitled “Targeting
results. Autophagy and Aberrant Metabolism of
Leukaemic Stem Cells”
The main aim of this project is to understand
how hypoxia, autophagy and mitochondrial
Gavin Turnbull, Masters Student
metabolism control the way in which Chronic
(MSci) has just started at POG as Myeloid Leukaemia stem cells function in the
part of his Masters course. bone marrow.
“I started working with POG in September as Ekaterini Himonas started in October 2020 POG Gin Club 2019
part of an integrated work placement course with Vignir Helgason on a project entitled – Gin Tasting Night –
with UoG. I chose to work with POG because “Identification of Clinically Applicable Inhibitors September 2019.
of the impressive work they do on leukaemia of Oxidative Phosphorylation in Myeloid
here in Glasgow. Leukaemia”. This is the second year of this
My work has focused on finding the specific Jamie Lees starts in January 2021 with Alison
event and once again was very
genes in cancer which are important for Michie’s group. Jamie’s PhD studentship well attended raising nearly
determining prognosis of a patient. The is funded by the Joan Snodgrass bequest. £3000 for POG. Big thank you
immediate effect of this task is putting Jamie’s PhD is entitled. “Exploiting the role of to all those who took part in
people on the right medication for them, individual members of the FOXO transcription the event and contributed to
and possibly finding new pathways to treat factor family: do they differentially regulate CLL raffle prizes and silent auction.
cancers in the future”. survival, proliferation and chemosensitivity?”
8 PAUL O’GORMAN NEWSLETTER WINTER 2020 FOR MORE INFORMATION, VISIT GLASGOW.AC.UK 9Mozart Concerts & CD, Of course, our fundraising efforts
2020 Paul O’Gorman Newsletter
December 2019. have been severely affected by
COVID-19 and a number of events UofG Paul O’Gorman Please fill in this form with a ball point pen
Penny Haydock reported that the
CD sales and concert had raised
had to be postponed including: Leukaemia Research Centre The University of Glasgow Trust is a registered charity, No. SC008303
The University of Glasgow is a registered charity, No. SC004401
approximately £600 and are available POG Golf Day –
Donation Form
at future events such as the craft Sunday 31 May 2020 Privacy Notice: The University will use the information you enter on this form to administer your gift. This may involve using the information you add here – or that
fairs etc. we already hold – to contact you if we have any questions about your gift. We may also use this information, including your telephone number and email address,
Kelvin Walkway Charity Walk – to contact you with news and information about how your gift is making a difference and other projects you may like to support. To manage your communications
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Young Once Concert, Hidden Gardens Day –
7 December 2019. Saturday 30 May 2020 1. Please tell us who you are 2. Please tell us what you would like to support
Sandra Moverley reported that the Tommy Burns Dinner –
Title Name
event raised £10,340 in total and 6 June 2020 3 Paul O’Gorman
this has been shared between Address Leukaemia Research Centre
Strathcarron Hospice, MND and POG
Christmas Craft Fair – - £3466.67 each
November 2019. We very much hope to Postcode
For assistance and to return your form:
Many thanks for everyone who POG Spring Event, 14 March 2020.
be able to reschedule Email: givingtoglasgow@glasgow.ac.uk
Telephone
contributed to this and helped these events in the or post to address overleaf
This took place at Knightswood
out on the day. Total amount coming year. Email
raised £848.94. Congregational Church Hall and
£261 was raised on the day
3. Making your gift
Making a single gift
I would like to make a single gift to the University of Glasgow Trust of £
Electronic funds transfer Boost your donation by 25p of Gift Aid for every £1 you donate
Ongoing Fundraising Events/Ideas: Susanne has also created these
Gift Aid is reclaimed by the charity from the tax you pay for the
beautiful Christmas cards with all Account Name: University of Glasgow Trust
current tax year. Your address is needed to identify you as a current
A special thanks to Susanne Hendry,
donations going to our funds also. Sort Code: 82-20-00 Account Number: 20006422
UK taxpayer.
Administrator at the WWCRC,
who raised funds for POG during Please quote your surname and 7 digit reference number at the top of this letter.
It would help if you could email givingtoglasgow.hubbub.net/p/glasgowgiving/ to confirm your gift.
In order to Gift Aid your donation you must tick the box below:
lockdown by making her drawing of I want to Gift Aid my donation and any donations I make
in the future, or have made in the past 4 years, to:
the University into cards. Susanne Online at: givingtoglasgow.hubbub.net/p/glasgowgiving/
University of Glasgow Trust
sold 300 cards raising £480 for POG.
Cheque or Charity Voucher (made payable to the University of Glasgow Trust)
Date:
“Nature’s gifts are free”. Making a regular gift by Direct Debit I am a UK taxpayer and understand that if I pay less Income Tax and/or
Capital Gains Tax than the amount of Gift Aid claimed on all my
These cards featuring a donations in that tax year it is my responsibility to pay any difference.
I would like to make a regular monthly quarterly annual gift of £
drawing of a little robin perched Please notify the University of Glasgow if you:
on a tree branch over the River to the University of Glasgow Trust until further notice, or for a period of years. Want to cancel this declaration/ Change your name or home address/
Kelvin, with the University bell No longer pay sufficient tax on your income and/or capital gains.
I would like the payments to be taken from my account on the 1st, or 15th of the month
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receive the additional tax relief due to you, you must include all your Gift
the University Main Building starting in (Please allow one month from today) Aid donations on your Self-Assessment tax return or ask HM Revenue
with nature all around it are the Please refer to section 4 to complete the Direct Debit instruction.
and Customs to adjust your tax code.
perfect way to keep in touch
with loved ones - https://www.
justgiving.com/fundraising/ 4. Instructions to your bank or building society to pay by Direct Debit
Susanne Hendry festivecardsforpog
Name and full postal address of your bank or building society Service user number: 257165
Reference number
To: The Manager,
Address
One of our Fundraising Committee members, Instruction to your bank or building society
Please pay the University of Glasgow Trust Direct Debits from the account detailed in this
Fiona Mackenzie, has been very busy making face instruction subject to the safeguards assured by the Direct Debit Guarantee. I understand
that this instruction may remain with the University of Glasgow Trust and, if so, details will be
Postcode
masks with 650 already done and many more on order. Name(s) of Account Holder(s)
passed electronically to my bank / building society.
She has raised £1800 for POG funds so far. Here is
Fiona modelling one of her creations and orders can Signature(s)
be placed via Fiona’s Facebook page – Branch Sort Code Date
https://www.facebook.com/mackdesignsglasgow/ Bank / Building Society Account Number Banks and building societies may not accept Direct Debit instructions for some types of account.
Fiona MacKenzie
10 PAUL O’GORMAN NEWSLETTER WINTER 2020Donation Form
The University of Glasgow Trust is a registered charity, No. SC008303
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“Thank you so much for your generosity.
Your donation will help us to continue our
research to develop better treatments for
blood cancer patients, and help to support Development & Alumni
students and members of staff to continue 3 The Square
this important work. It is very humbling to University of Glasgow
see the dedication and hard work of not just Glasgow
our fundraisers, but also the staff at POG in
G12 8QQ
our shared goal of curing blood cancers in
the future.”
Professor Mhairi Copland, Director,
Paul O’Gorman Leukaemia Research CentreYou can also read
