NATIONAL LIST OF ESSENTIAL MEDICINES NEPAL - (Fourth Revision) - DEPARTMENT OF DRUG ADMINISTRATION
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Final Draft NATIONAL LIST OF ESSENTIAL MEDICINES NEPAL (Fourth Revision) Government of Nepal MINISTRY OF HEALTH AND POPULATION DEPARTMENT OF DRUG ADMINISTRATION 2009
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Final Draft NATIONAL LIST OF ESSENTIAL MEDICINES - NEPAL Fourth revision, 2009 ________________________________________________________________ Generic Name Dosage Form 1. Anaesthetics 1.1 General Anaesthetics and Oxygen Halothane inhalation Isoflurane inhalation Ketamine injection, 50 mg/ml (as hydrochloride) in 10-ml vial Nitrous oxide inhalation Oxygen inhalation (medicinal gas) Thiopental powder for injection, 0.5g, 1.0g (sodium salt) in ampoule Complementary Propofol injection, 10mg/ml in 20-ml ampoule 1.2 Local Anaesthetics Bupivacaine injection, 0.25%, 0.5% (hydrochloride) in vial Lidocaine (Lignocaine) injection, 1%, 2% (hydrochloride) in vial; injection for spinal anaesthesia, 5% (hydrochloride) in 2-ml ampoule to be mixed with 7.5% glucose solution Lidocaine + epinephrine (adrenaline) injection, lignocaine 2%(hydrochloride) + epinephrine 1:200 000, in vial Complementary Ephedrine injection, 30 mg (hydrochloride)/ml in 1-ml ampoule (For use in spinal anaesthesia during delivery, to prevent hypotension) 1.3 Preoperative Medication and Sedation for Short-term Procedures Atropine injection, 1 mg (sulfate) in 1-ml ampoule Diazepam injection, 5mg/ml in 2-ml ampoule Morphine injection, 10 mg (sulfate or hydrochloride) in 1-ml ampoule 2. Analgesics, Antipyretics, Non-Steroidal Anti-inflammatory Medicines (NSAIMs) and Medicines Used to Treat Gout and Disease-Modifying Agents Used in Rheumatic Disorders (DMARDs) 2.1. Non-opioids Analgesics & NSAIMs Ibuprofen tablet, 200 mg, 400 mg Paracetamol tablet, 500mg; injection, 150 mg/ml; oral liquid, 125 mg/5ml Complementary Aspirin tablet, 300 mg Diclofenac sodium tablet, 50 mg; injection, 25 mg/ml 1
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 2.2. Opioid Analgesics Morphine injection, 10 mg (sulfate or hydrochloride) in 1- ml ampoule; tablet, 10mg; prolonged release tablet, 10mg, 30mg, 60 mg (sulfate); oral liquid 10 mg/5ml (sulfate) Pethidine injection, 50mg (hydrochloride) in 1-ml ampoule 2.3 Medicines Used to Treat Gout Complementary Allopurinol tablet, 100 mg Colchicine tablet, 500 mcg 2.4 Disease Modifying Agents Used in Rheumatic Disorders (DMARDs) Methotrexate tablet, 2.5mg (as sodium salt) 3. Antiallergics and Medicines Used in Anaphylaxis 3.1 Antiallergics Chlorpheniramine tablet, 4 mg (maleate) Dexamethasone phosphate injection, 4 mg (as sodium salt) in 1-ml ampoule Epinephrine (adrenaline) injection, 1mg (as hydrochloride or tartrate) in 1-ml ampoule Hydrocortisone powder for injection, 100 mg (as sodium succinate) in vial Pheniramine injection, 22.75 mg (maleate) /ml Prednisolone tablet, 5mg 3.2 Medicines Used in Shock Dopamine injection, 40 mg/ml Epinephrine (Adrenaline) injection, 1:10 000 in 1-ml ampoule 4. Antidotes and Other Substances Used in Poisonings 4.1 Non-Specific Charcoal, activated powder; slurry in sorbitol 4.2 Specific Atropine injection, 1 mg (sulfate) in ampoule; powder for injection 200 mg (sulfate) in vial Dimercaprol injection in oil, 50 mg/ml in 2-ml ampoule Naloxone injection, 400 mcg (hydrochloride) in 1-ml ampoule Pralidoxime injection, 500 mg or 1 g (mesilate, chloride or iodide) in ampoule Complementary Acetylcysteine injection, 200 mg/ml in 10-ml ampoule Calcium gluconate injection, 100 mg/ml in 10-ml ampoule Deferoxamine powder for injection, 500 mg (mesilate) in vial Methylthioninium chloride (Methylene injection, 10 mg/ml in 10-ml ampoule blue) Potassium ferric hexacyano-ferrate powder for oral administration (II).2H2O (Prussian blue) Sodium calcium edetate injection, 200 mg/ml in 5-ml ampoule Sodium nitrite injection, 30 mg/ml in 10-ml ampoule 2
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 5. Antiepileptics / Anticonvulsants Carbamazepine tablet, 100 mg, 200 mg; chewable tablet 100 mg, 200 mg Diazepam injection, 5mg/ml in 2-ml ampoule (intravenous or rectal) Magnesium sulfate* injection, 500 mg/ml in 2-ml ampoule. * For use in eclampsia and severe pre-clampsia and not for other convulsant disorders Phenobarbital tablet, 15 mg, 30 mg Phenytoin capsule or tablet, 25 mg, 50 mg, 100 mg (sodium salt); injection, 50 mg /ml (sodium salt) in 5-ml vial Valproic acid tablet (enteric coated), 200 mg (sodium salt) Complementary Paraldehyde injection, 500 mg/ml in 2-ml ampoule 6. Anti-infective Medicines 6.1 Anthelmintics 6.1.1 Intestinal Anthelmintics Albendazole tablet (chewable), 400 mg Complementary Niclosamide tablet (chewable), 500mg Praziquantel tablet, 150 mg, 600 mg 6.1.2 Antifilarials Diethylcarbamazine tablet, 50 mg, 100 mg (dihydrogen citrate) 6.2 Antibacterials 6.2.1 Beta-lactum medicines Amoxicillin capsule or tablet, 250mg, 500mg (as trihydrate); dispersible tablet 125 mg (as trihydrate) Ampicillin powder for injection, 500 mg (sodium salt) Benzathine benzylpenicillin powder for injection, 600 000 IU, 1200 000 IU, 2400 000 IU in vial Benzylpenicillin (Penicillin G) powder for injection, 300 mg (0.5 million IU), 600 mg (1 million IU) (as sodium or potassium salt) in vial Cefixime# tablet, 400 mg #Only listed for single-dose treatment of uncomplicated ano-genital gonorrhoea Cefotaxime powder for injection, 1g, 500 mg (as sodium salt) in vial Cloxacillin capsule, 250 mg, 500 mg; powder for oral liquid, 125 mg / 5ml; powder for injection, 500 mg (as sodium salt) in vial Phenoxymethylpenicillin (Penicillin V) tablet, 250mg (as potassium salt); powder for oral liquid, 250 mg Procaine benzylpenicillin powder for injection, 300,000 IU in vial Complementary Cefazolin* powder for injection, 1 g (as sodium salt) in vial *For surgical prophylaxis Ceftriaxone powder for injection, 250 mg (as sodium salt) in vial 3
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 6.2.2 Other Antibacterials Azithromycin* capsule or tablet 250 mg, 500 mg; oral liquid, 200 mg /5ml. *Only listed for single-dose treatment of genital Chlamydia trachomatis and of trachoma. Chloramphenicol capsule, 250 mg, 500 mg; oral liquid, 125 mg / 5ml (as palmitate), powder for injection, 1g (as sodium succinate) in vial Ciprofloxacin tablet, 250 mg, 500 mg (as hydrochloride) Doxycycline capsule, 100mg (as hydrochloride) Gentamicin injection, 10 mg, 40 mg / ml (as sulfate) in 2-ml vial Metronidazole tablet, 200 mg, 400 mg; injection, 500 mg in 100-ml vial; oral liquid, 100 mg, 200 mg (as benzoate) / 5ml Nitrofurantoin tablet, 100 mg Sulfamethoxazole+Trimethoprim dispersible tablet, 100mg+20 mg, 200 mg+ 40 mg; tablet 400 mg + 80 mg, 800 mg + 160 mg; oral liquid, 200mg + 40mg /5ml Complementary Erythromycin tablet, 250 mg (stearate); oral liquid, 250 mg / 5ml (stearate) Nalidixic acid tablet, 250 mg, 500 mg 6.2.3 Antileprosy Medicines Clofazimine capsule, 50 mg, 100 mg Dapsone tablet, 50 mg, 100 mg Rifampicin capsule or tablet 150 mg, 300 mg 6.2.4 Antitubercular Medicines Ethambutol tablet, 400 mg (hydrochloride) Isoniazid tablet, 100 mg, 300 mg Isoniazid+ethambutol tablet, 150mg + 400mg Rifampicin capsule or tablet, 150mg, 300mg Rifampicin+isoniazid tablet, 60 mg+ 30 mg, 150mg + 75 mg Rifampicin+isoniazid+ethambutol tablet, 150 mg+ 75 mg+275 mg Rifampicin+isoniazid+pyrazinamide tablet, 60 mg+ 30 mg+150 mg Rifampicin+isoniazid+pyrazinamide+ ethambutol tablet, 150 mg+ 75 mg + 400 mg + 275 mg Streptomycin powder for injection, 1 g (as sulfate) in vial Complementary list: Second-line medicines for the treatment of multi-drug resistant tuberculosis (MDR-TB) - to be made available only in specialised centres adhering to standard treatment protocol. Cycloserine tablet, 250 mg Ethionamide tablet, 250 mg Kanamycin powder for injection 1 g in vial Ofloxacin tablet, 200 mg p-aminosalicylic acid (PAS) granules, 4 g in sachet; tablet 500 mg 4
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Pyrazinamide tablet, 400mg 6.3 Antifungal Medicines Clotrimazole cream, 1%; pessary 100 mg Fluconazole capsule or tablet, 150 mg Nystatin lozenge, 100 000 IU 6.4 Antiviral Medicines 6.4.1 Antiherpes Medicines Aciclovir powder for injection 250 mg (as sodium salt) in vials, tablet 200 mg 6.4.2 Antiretrovirals 6.4.2.1 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors Abacavir (ABC) tablet, 300 mg (as sulfate); oral liquid, 100 mg (as sulfate)/5ml Didanosine (ddI) enteric coated capsules 250 mg, 400 mg Lamivudine (3TC) tablet, 150 mg; oral liquid 50 mg/5ml Stavudine (d4T) capsule, 15 mg, 20 mg, 30 mg; powder for oral liquid, 5 mg/5 ml Tenofovir disoproxil fumarate (TDF) tablet, 300 mg (equivalent to 245 mg tenofovir disoproxil) Zidovudine (ZDV or AZT) capsule, 100 mg; tablet 300 mg; oral liquid 50 mg/ 5ml 6.4.2.2 Non-nucleoside Reverse Transcriptase Inhibitors Efavirenz (EFV or EFZ) capsule, 200 mg; tablet, 600 mg Nevirapine (NVP) tablet, 200 mg; oral liquid, 50 mg/5ml 6.4.2.3 Protease Inhibitors Indinavir (IDV) capsule, 400 mg ( as sulfate) Lopinavir + ritonavir (LPV/r) capsule 200 mg + 50 mg Nelfinavir (NFV) tablet, 250 mg (as mesilate) Saquinavir (SQV)+ritonavir oral dosage form, 1g+100 mg 6.4.2.4 Fixed-dose Combination Lamivudine + stavudine tablet, 150 mg + 30 mg Stavudine + lamivudine + nevirapine tablet, 30 mg + 150 mg + 200 mg Zidovudine + lamivudine tablet, 300 mg + 150 mg Zidovudine + lamivudine + nevirapine tablet, 300 mg + 150 mg + 200 mg 6.5 Antiprotozoal Medicines 6.5.1 Antiamoebic and Antigiardiasis Medicines Diloxanide tablet, 500 mg (furoate) Metronidazole tablet, 200mg, 400mg; oral liquid, 200 mg (as benzoate) / 5 ml. Complementary Tinidazole tablet, 500mg 6.5.2 Antileishmaniasis Medicines Miltefosine capsule, 50 mg Complementary Amphotericin B powder for injection, 50 mg in vial Sodium stibogluconate injection, 100mg/ml 6.5.3 Antimalarial Medicines 5
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Artesunate injection, ampoules, containing 60 mg anhydrous artesunic acid with a separate ampoule of 5% sodium bicarbonate solution; tablet 50 mg Artemether* oily injection, 80 mg/ml in 1-ml ampoule. * For use in the management of severe malaria. Artemether+lumefantrine# tablet, 20 mg+ 120 mg # Not recommended in the first trimester of pregnancy or in children below 5 kg. Chloroquine tablet, 150 mg base (as phosphate or sulfate); oral liquid, 50 mg/5ml (as phosphate or sulfate); injection, 40mg/ml in 5-ml ampoule (as phosphate, sulfate or hydrochloride) Primaquine tablet, 7.5 mg, 15 mg (as diphosphate) Sulfadoxine + Pyrimethamine tablet, 500 mg + 25 mg Complementary Quinine tablet, 300 mg (as bisulfate or sulfate) injection, 300mg (as dihydrochloride)/ ml in 2-ml ampoule. 7. Antimigraine Medicines 7.1 For Treatment of Acute Attack Paracetamol tablet, 500 mg Ergotamine tablet, 1 mg (tartrate) 7.2 For Prophylaxis Propranolol tablet 20 mg, 40mg (hydrochloride) 8. Antineoplastic, Immunosuppressives and Medicines Used in Palliative Care 8.1 Immunosuppressive Medicines Ciclosporin capsule 25 mg 8.2 Cytotoxic Medicines L-Asparaginase injection, 5 000 IU, 10 000 IU in vial Calcium folinate (Calcium leucovorin) tablet, 15 mg Cisplatin powder for injection, 10 mg, 50 mg in vial. Cyclophosphamide tablet, 25 mg; powder for injection, 200 mg, 500 mg, 1 g in vial Cytarabine injection 100 mg, 500 mg in vial Doxorubicin powder for injection, 10 mg, 50 mg in vial Etoposide injection 20 mg/ml in 5-ml ampoule Fluorouracil injection 50 mg/ml in 5-ml, 10-ml ampoule Granulocyte Colony Stimulating Factor injection, 30 million (GCSF) unit in vial Hydroxy urea capsule 500 mg Ifosfamide + Mensa injection, 1g + 200 mg, in vial Melphalan tablet, 2 mg, 5 mg; powder for injection, 50mg in vial Mercaptopurine tablet, 50 mg Methotrexate tablet, 2.5 mg (as sodium salt); powder for injection 15 mg, 50 mg (as sodium salt) in vial Mitomycin powder for injection, 2mg, 10mg, 20mg in vial Ondansetron injection, 2 mg/ml in 2-ml, 4-ml vial; tablet 2mg, 4mg Vincristine powder for injection, 1 mg (sulfate) in vial Complementary 6
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Bleomycin powder for injection, 15mg (as sulfate) in vial Carboplatin injection 150 mg, 450 mg in vial Chlorambucil tablet, 2 mg, 5 mg Dactinomycin powder for injection, 500 mcg in vial Daunorubicin powder for injection 20 mg (as hydrochloride) in vial Dacarbazine powder for injection, 100 mg in vial Epirubicin injection, 10 mg, 50 mg (hydrochloride) in vial Interferon injection, 5 million units/ml in vial Lomustine capsule, 40 mg Mitoxantrone injection, 2 mg/ml in 10ml ampoule Vinblastine powder for injection 10 mg (sulfate) in vial 8.3 Hormones and Antihormones Hydrocortisone powder for injection, 100 mg (as sodium succinate) in vial Tamoxifen tablet, 20mg (as citrate) Complementary Bicalitumide tablet or capsule 50 mg Dexamethasone phosphate 4 mg /ml (as sodium salt) in 2-ml ampoule Prednisolone tablet, 5 mg, 10 mg, 20 mg 9. Antiparkinsonism Medicines Levodopa + Carbidopa tablet, 100 mg + 10 mg, 250 mg + 25 mg Trihexyphenidyl tablet, 2 mg (hydrochloride) 10. Medicines Affecting the Blood 10.1 Antianaemia Medicines Ferrous salt (Ferrous sulfate)* tablet, equivalent to 60 mg Iron; oral liquid, equivalent to 25 mg iron/ ml Ferrous salt (sulfate)*+Folic acid tablet, equivalent to 60 mg Iron+ 400 mcg Folic acid. Folic acid tablet, 5mg *Other salts of Iron may be used Complementay Iron Dextran injection, equivalent to 50 mg iron/ml in 2-ml ampoule 10.2 Medicines Affecting Coagulation Heparin sodium injection, 1000 IU / ml, 5000 IU / ml, 20000 IU / ml in 1- ml ampoule Phytomenadione injection, 10mg / ml in 5-ml ampoule; tablet 10 mg Protamine sulfate injection, 10mg/ml in 5-ml ampoule Warfarin tablet, 5 mg (sodium salt) Complementary Acenocoumarol tablet, 1mg 11. Blood Products and Plasma Substitutes 7
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 11.1 Plasma Substitutes Albumin, human injectable solution, 20 or 25% Polygeline injectable solution, 3.5% 11.2 Plasma Fractions For Specific Use Factor VIII Concentrate dried concentrate Factor IX complex dried concentrate 12. Cardiovascular Medicines 12.1 Antianginal Medicines Atenolol tablet, 50 mg, 100 mg Glyceryl trinitrate tablet (sublingual), 500 mcg Verapamil tablet, 40 mg, 80 mg (hydrochloride); injection, 2.5 mg / ml in 2-ml ampoule 12.2 Antiarrhythmic Medicines Atenolol tablet 25 mg, 50 mg, 100 mg Digoxin tablet, 62.5mcg, 250mcg; oral liquid, 50 mcg / ml; injection, 250 mcg / ml in 2-ml ampoule Isoprenaline injection, 1 mg (hydrochloride)/ml in vial Complementary Disopyramide capsule, 100 mg, 150 mg Procainamide tablet, 250mg (hydrochloride); injection, 100 mg /ml in 10-ml ampoule 12.3 Antihypertensive Atenolol tablet, 50 mg, 100 mg Enalapril tablet, 5 mg, 10 mg, 20 mg Hydrochlorothiazide tablet, 25 mg, 50 mg Nifedipine capsule or tablet, 10 mg, 20 mg Complementary Prazosin tablet 500 mcg, 1mg (mesilate) Sodium nitroprusside powder for infusion, 50 mg in ampoule 12.4 Medicines Used in Heart Failure Digoxin tablet, 62.5 mcg, 250 mcg; oral solution, 50 mcg / ml; injection, 250 mcg / ml in 2-ml ampoule Captopril tablet, 12.5 mg, 25 mg Complemenary Dobutamine injection 250 mg/ 20ml, 50 mg/ml 12.5 Antithrombotic Medicines Aspirin tablet, 50mg, 75 mg, 100mg Streptokinase injection 750 000 IU, 1500 000 IU in vial 12.6 Lipid Lowering Agent Atorvastatin tablet, 10 mg, 20 mg (as calcium trihydrate) 13. Dermatological Medicines 13.1 Antifungal Medicines Benzoic acid + Salicylic acid ointment or cream, 6% + 3% 8
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Clotrimazole cream, 1% Complementary Selenium sulfide detergent-based suspension, 2% 13.2 Anti-infective Medicines Povidone iodine solution, 5% Silver sulfadiazine cream, 0.2% Complementary Gentian violet aqueous solution 1% (Methylrosanilinium chloride) 13.3 Anti-inflammatory and Antipruritic Medicines Betamethasone ointment or cream, 0.1% (as valerate) Calamine lotion lotion, 15% Hydrocortisone ointment or cream, 1% (acetate) 13.4 Medicines Affecting Skin Differentiation and Proliferation Benzoyl peroxide cream or lotion, 5% Coal tar solution, topical 5% 13.5 Scabicides and Pediculicides Lindane cream or lotion, 1% (Gamma benzene hexachloride) Complementary Permethrin lotion 1%, cream 5% 14. Diagnostic Agents 14.1 Ophthalmic Medicines Fluorescein eye drops, 1%, 2% (sodium salt); injection, 10%, 20% (sodium salt) in 5-ml ampoule 14.2 Radiocontrast Media Amidotrizoate injection, 140-420 mg iodine/ml (as sodium or meglumine salt) in 20ml ampoule Barium sulfate aqueous suspension Iohexol injection, 140-350 mg iodine/ml in 5-ml, 10-ml ampoule Complementary Meglumine iotroxate solution, 5-8 g iodine in 100-250 ml 15. Disinfectants and Antiseptics 15.1 Antiseptics Chlorhexidine solution, 5% (digluconate) for dilution Chlorine based compound powder, (0.1% available chlorine) for solution Gentian violet aqeous solution 1% (Methylrosanilinium chloride) Povidone iodine solution, 5% Rectified spirit liquid 9
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 15.2 Disinfectants Formaldehyde solution, 3% Glutaraldehyde solution, 2% Cetrimide solution, 20% for dilution 16. Diuretics Furosemide tablet, 40 mg; injection, 10 mg/ml in 2-ml ampoule Hydrochlorothiazide tablet, 25mg, 50mg Mannitol injectable solution, 10%, 20% Spironolactone tablet, 25mg, 100mg Triamterene tablet, 50mg 17. Gastrointestinal Medicines 17.1 Antacids and Other Anti-ulcer Medicines Dried aluminium hydroxide gel + tablet, 250mg + 250 mg Magnesium hydroxide Ranitidine tablet, 150 mg, 300 mg (as hydrochloride); injection 25 mg/ml in 2-ml ampoule Complementary Omeprazole tablet, 20 mg 17.2 Antiemetic Medicines Metoclopramide tablet, 10 mg (hydrochloride); injection,5mg (hydrochloride)/ml in 2-ml ampoule Promethazine tablet, 25 mg (theoclate); oral liquid, 5 mg (hydrochloride)/ 5ml; injection, 25 mg (hydrochloride) / ml in 2-ml ampoule 17.3 Anti-inflammatory Medicines Sulfasalazine tablet, 500 mg 17.4 Laxatives Magnesium sulfate powder, 500 g Lactulose solution, 3.35 mg / 5ml Complementary Bisacodyl tablet, 10 mg 17.5 Medicines Used in Diarrhoea 17.5.1 Oral Rehydration Oral rehydration salts* sachet containing: Dextrose, anhydrous 13.5 g, Sodium chloride 2.6 g, Potassium chloride 1.5 g, Trisodium citrate dihydrate 2.9 g, appropriate flavour q.s. Dissolved to produce 1 litre, provides dextrose 75 mEq, sodium 75 mEq or mmol/l, chloride 65 mEq or mmol/l, potasium 20 mEq or mmol/l, citrate 10 mmol/l and osmolarity 245 mOsm/l * In case of cholera a higher concentration of sodium may be required. 17.5.2 Medicine for Diarrhoea in Children 10
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Zinc sulfate* dispersible tablet, equivalent to Zinc 10 mg, 20 mg (scored) * In acute diarrhoea, zinc sulfate should be used as an adjunct to oral rehydration salts 17.6 Antispasmodic Medicines Hyoscine butylbromide tablet, 10 mg, 20 mg; injection, 20mg/ml in 1-ml ampoule 18. Hormones, Other Endocrine Medicines and Contraceptives 18.1 Adrenal Hormones and Synthetic Substitutes Dexamethasone tablet, 500 mcg; injection, 4 mg/ml (as sodium phosphate) in 1-ml ampoule Hydrocortisone powder for injection, 100 mg (as sodium succinate) in vial; tablet, 10 mg, 20 mg Prednisolone tablet, 5 mg, 10 mg Complementry Fludrocortisone tablet, 100 mcg (acetate) 18.2 Androgens Testosterone injection, 200 mg in 1-ml ampoule 18.3 Contraceptives 18.3.1 Oral Harmonal Contraceptives Ethinylestradiol + Levonorgestrel tablet, 30 mcg +150 mcg Ethinylestradiol + Norethisterone tablet, 35 mcg + 1.0 mg Levonorgestrel tablet, 750 mcg (pack of two), 1.5 mg 18.3.2 Injectable Hormonal Contraceptive Medroxyprogesterone acetate depot injection, 150 mg / ml in 1-ml vial 18.3.3 Intrauterine Devices Copper-containing devices Ring pessary 18.3.4 Barrier Methods Condoms 18.3.5 Implantable Contraceptives Levonorgestrel-releasing implant Two-rod levonorgeatrel-releasing implant, each rod containing 75 mg of levonorgestrel (150 mg total) 18.4 Estrogens Ethinylestradiol tablet, 50 mcg 18.5 Insulins and Other Antidiabetic Agents Glibenclamide tablet, 2.5mg, 5 mg Insulin - injection (soluble) injection, 40 IU / ml in 10- ml vial Intermediate acting insulin injection, 40 IU / ml in 10- ml vial (as compound insulin zinc suspension or isophane insulin) Metformin tablet, 500mg (hydrochloride) Complementary Glipizide tablet, 2.5 mg, 5 mg 11
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 18.6 Ovulation Inducers Clomifene tablet, 50 mg (citrate) 18.7 Progestogens Norethisterone tablet, 5 mg Medroxyprogesterone acetate tablet, 5 mg 18.8 Thyroid Hormones and Antithyroid Medicines Carbimazole tablet, 5 mg Levothyroxine tablet, 100 mcg (sodium salt) Lugol's Iodine oral solution (Iodine 5%+Potassium iodide 10%) 18.9 Posterior Pituitary Hormone Desmopressin injection, 4 mcg/ml; nasal spray 10 mcg / metered spray 19. Immunologicals 19.1 Diagnostic Agents Tuberculin, purified protein derivative injection (PPD) 19.2 Sera and Immunoglobulins Anti-D immunoglobulin (human) injection, 250 mcg in single dose vial Antirabies hyperimmune serum injection, 1000 IU in 5-ml ampoule Polyvenum antisnake serum injection in vial Tetanus antitoxin injection, 1 000 IU, 3 000 IU in vial Tetanus immunoglobulin (human) injection, 500 IU in vial 19.3 Vaccines 19.3.1 For Universal Immunization BCG vaccine Diphtheria-Tetanus-Pertussis-Hepatitis B vaccine Diphtheria- Tetanus- Pertussis- Hepatitis B -Haemophilus type b vaccine Measles vaccine (live attenuated) Poliomyelitis (oral) vaccine Tetanus toxoid (Tetanus vaccine) vaccine 19.3.2 For Specific Groups of Individuals Hepatitis A vaccine Hepatitis B vaccine Influenza vaccine Japanese Encephalitis SA 14-14-2 strain live attenuated vaccine Meningococcal vaccine vaccine Mumps vaccine Rabies vaccine, freeze-dried vaccine Rubella vaccine Typhoid vaccine Yellow fever vaccine vaccine 20. Muscle Relaxants (Peripherally Acting) and Cholinesterase Inhibitors 12
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Neostigmine tablet, 15 mg (bromide); injection 500 mcg, 2.5 mg (metilsulfate) in 1-ml ampoule Pancuronium bromide injection, 2 mg / ml in 2-ml ampoule Suxamethonium chloride injection, 50mg /ml in 2- ml ampoule Vecuronium bromide powder for injection 10 mg in vial 21. Ophthalmological, Ear, Nose and Throat Preparations 21.1 Ophthalmological Preparations 21.1.1 Anti-infective Agents Aciclovir ointment, 3%w/w Gentamicin solution (eye drops), 0.3% Complementary Chloramphenicol applicap 1% Ciprofloxacin eye/ear drops, 0.3% (as hydrochloride); eye ointment, 0.3% Tetracycline eye ointment, 1% (hydrochloride) 21.1.2 Anti-inflammatory agents Prednisolone solution (eye drops), 0.5% 21.1.3 Local Anaesthetics Lignocaine (Lidocaine) injection, 2%, 4% (topical) Complementary Tetracaine solution (eye drops), 0.5% 21.1.4 Miotics and antiglaucoma medicines Acetazolamide tablet, 250 mg Pilocarpine solution (eye drops), 2%, 4% (hydrochloride) Timolol solution (eye drops), 0.5 % (maleate) 21.1.5 Mydriatics Atropine solution (eye drops), 1% (sulfate) 21.2. Ear, Nose and Throat Preparations Lignocaine (Lidocaine) topical (viscous), 2%, 4% Bismuth Iodoform Paraffin solution, 70% Chloramphenicol ear drops, 5% Ichthammol + Glycerine ear drop, 10%+5% Oxymetazoline solution (nasal drops), 0.025%, 0.05% Sodium bicarbonate + Glycerin ear drops, 1%+5% 21.3 Dental Clove oil oil Chlorhexidine solution, 0.2% Zinc oxide powder 22. Oxytocics and Antioxytocics 22.1 Oxytocics Methylergometrine tablet, 200mcg (hydrogen maleate); injection, 200mcg 1- ml ampoule Oxytocin injection, 5 IU/ml in 2-ml ampoule 13
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Complementary Misoprostol vaginal or oral tablet, 25 mcg Mifepristone*-misoprostol tablet, 200mg- 200 mcg * Combi-pack, containing 1 tablet of mifepristone and 4-tablet of misoprostol. Requires close medical supervision. Approved for abortion services only in listed sites. 22.2 Anti-oxytocics Isoxsuprine injection, 5mg/ml 23. Peritoneal Dialysis Solution Intraperitoneal dialysis solution parenteral solution of appropriate composition 24. Psychotherapeutic Medicines 24.1 Medicines Used in Psychotic Disorders Chlorpromazine tablet, 50 mg, 100mg (hydrochloride); oral liquid, 25 mg (hydrochloride) / 5ml; injection, 25 mg (hydrochloride) / 5ml in 2-ml ampoule Fluphenazine injection, 25 mg (decanoate or enantate) in 1-ml ampoule Haloperidol tablet 2 mg, 5 mg; injection, 5 mg in 1-ml ampoule Complementary Thioridazine tablet, 10mg, 25mg, 100mg 24.2 Medicines Used in Mood Disorders 24.2.1 Medicines used in depressive disorders Amitriptyline tablet, 10 mg, 25 mg, 75mg (hydrochloride) Fluoxetine capsule or tablet, 20 mg (as hydrochloride) 24.2.2 Medicines Used in Bipolar Disorders Lithium carbonate capsule or tablet, 300mg 24.3 Medicines Used in Generalised Anxiety and Sleep Disorders Alprazolam tablet, 0.25 mg, 0.5 mg, 1 mg Chlordiazepoxide tablet, 10 mg, 25 mg Diazepam tablet 2 mg, 5 mg 24.4 Medicines Used for Obsessive Compulsive Disorders and Panic Attacks Clomipramine capsules, 10 mg, 25 mg (hydrochloride) 24.5 Medicines Used in Substance Dependence Programmes Methadone* concentrate for oral liquid, 5 mg/ml, 10 mg/ml (hydrochloride), oral liquid, 5 mg/5ml, 10 mg/5 ml *The medicines should only be used within an established support 25. Medicines Acting on the Respiratory Tract 25.1 Antiasthmatic and Medicines for Chronic Obstructive Pulmonary Disease Aminophylline Injection, 25 mg/ml Epinephrine (Adrenaline) injection, 1 mg (as hydrochloride or hydrogen tartrate) in 1-ml ampoule. Hydrocortisone injection (sodium succinate) 100 mg, 200 mg in vial; tablet, 10 mg Ipratropium bromide inhalation, 20 mcg/ dose 14
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Salbutamol tablet, 2 mg, 4 mg (as sulfate); rotacap 200 mcg (as sulfate) per dose; oral liquid, 2mg (as sulfate)/5ml; injection 50mcg /ml in 5-ml ampoule Sodium cromoglicate inhalation (aerosol), 5 mg, 20 mg per dose Complementary Beclomethasone inhalation (aerosol), 50mcg (as dipropionate) per dose Theophylline tablet, 300 mg 26. Solution Correcting Water, Electrolyte and Acid Base Disturbances 26.1 Oral Oral rehydration salts* sachet containing: Dextrose, anhydrous 13.5 g, Sodium chloride 2.6 g, Potassium chloride 1.5 g, Trisodium citrate dihydrate 2.9 g, appropriate flavour q.s. Dissolved to produce 1 litre, provides Dextrose 75 mEq, sodium 75 mEq or mmol/l, chloride 65 mEq or mmol/l, potasium 20 mEq o mmol/l, citrate 10 mmol/l and osmolarity 245 mOsm/l 26.2 Parenteral Compound solution of Sodium lactate injectable solution (Ringer's Lactate) Glucose injectable solution, 5% isotonic, 50% hypertonic Glucose with Sodium chloride injectable solution, 5% glucose, 0.9% sodium chloride Potassium chloride injection, 11.2% in 20ml ampoule Sodium chloride injectable solution, 0.9% isotonic Sodium bi-carbonate injectable solution 1.4%, 8.4% solution in 10-ml ampoule 26.3 Miscellaneous Water for injection 5-ml, 10-ml ampoule Ethyl alcohol injection Complementary Disulfiram tablet, 200 mg 27. Vitamins and Minerals Ascorbic acid tablet, 50mg Calcium gluconate injection, 100 mg / ml in 10-ml ampoule Ergocalciferol capsule or tablet, 1.25 mg (50 000 IU) oral solution, 250 mcg/ ml (10000 IU / ml) Pyridoxine tablet, 25mg (hydrochloride) Retinol tablet (sugar coated), 10000 IU (5.5mg. capsule, 20000 IU (as palmitate 110 mg; oral oily solution, 100 000 IU/ ml; water miscible injection, 100 000 IU (as palmitate) 55 mg in 2-ml ampoule Retinol +DL-alpha-tocopherol Retinol (as palmitate)+DL-alpha-tocopherol or tocopheryl acetate, soft gel capsule, 200 000 IU+ 40 IU, 100 000 IU+ 20 IU, 50 000 IU+ 20 IU Riboflavin tablet, 5 mg Vitamin B complex tablet containing: 15
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 thiamine mononitrate 5 mg, riboflavin 5 mg, pyridoxine hydrochloride 1.5 mg, nicotinamide 50 mg, calcium pantothenate 25 mg. ******** LIST OF ESSENTIAL MEDICINES FOR DISTRICT HOSPITAL, PRIMARY HEALTH CARE CENTRE, HEALTH POST AND SUB-HEALTH POST (Note: The main list is for District hospital. Column at right hand side mentions which medicines are listed below district hospital. PHC: Primary Health Care Centre, HP: Health Post, SHP: Sub-health Post. "y" in the chart indicates that the medicine is included and (-) indicates the medicine is not included in the list of essential medicines for that level of health facility. (C) or "complementary" indicates that the medicine is complementary for that level of health facility. @ indicates the medicines listed for free health care. y@ means the medicine is listed for free healthcare service at that level of health facility. (For example. 4.1 Charcoal activated is listed for district hospital, PHC and HP, but not for SHP. If @ is only in the name of medicine, it means that it is listed for free health care service at district hospital only, for example, 2.1 Aspirin. ) _____________________________________________________________________________________ Generic name Dosage Form Health facility PHC HP SHP 16
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 ------------------------------------------------------------------------------------------------------------------------------------------------------- 1. Anaesthetics 1.1 General Anaesthetics and Oxygen Halothane inhalation - - - Ketamine injection, 50 mg /ml in 10 ml vial y - - Oxygen inhalation (medicinal gas) y - - Thiopental powder for injection, 0.5 g, 1.0 g in ampoule - - - 1.2 Local anaesthetics Lignocaine@ (lidocaine) injection, 2% in vial y@ y@ y@ Lignocaine + epinephrine Lignocaine 2% (hydrochloride) + (Lidocaine+adrenaline) epinephrine 1:200 000, in vial - - - 2. Analgesics, Antipyretics, Non-Steroidal Anti-inflammatory Medicines (NSAIMs), Medicines Used to Treat Gout and Disease-Modifying Agents Used in Rheumatic Disorders (DMARDs) 2.1 Non-opioids and Nonsteroidal Anti-inflammatory Medicines (NSAIMs) Ibuprofen tablet, 200 mg, 400 mg y y y Paracetamol@ tablet, 500mg; oral liquid, 125 mg/5ml; injection, 150 mg/ml y@ y@ y@ Complementary Aspirin@ 300 mg y y y Diclofenac sodium tablet, 50 mg y - - injection, 25 mg in 1-ml vial y y - 2.2 Opioid Analgesics Pethidine injection, 50mg (hydrochloride) in 1-ml ampoule y - - 2.3 Drugs Used to Treat Gout Complementary Allopurinol tablet, 100 mg y - - Colchicine tablet, 500 mcg y - - 3. Antiallergics and Medicines Used in Anaphylaxis 3.1 Antiallergics Chlorpheniramine@ tablet, 4 mg (maleate) y@ y@ y@ Epinephrine (adrenaline) injection, 1mg in 1-ml ampoule y y y Hydrocortisone powder for injection, 100mg (as sodium succinate) y - - Pheniramine@ injection, 22.75 mg (maleate) /ml y@ y@ y@ Prednisolone tablet, 5mg y - - 3.2 Drugs Used in Shock Dopamine injection, 40 mg/ml y - - Epinephrine injection, 1:10 000 in 1-ml ampoule y - - 4. Antidotes and Other Substances Used in Poisonings 4.1 Non-Specific Charcoal, activated @ powder y@ y@ - 4.2 Specific Atropine@ injection, 1 mg (sulfate) y@ y@ - Naloxone injection, 400 mcg in 1-ml ampoule y - - Pralidoxime injection, 1g or 500mg (mesilate, chloride or iodide) in ampoule y - - Complementary Acetylcysteine injection, 200 mg/ml in 10-ml vial - - - 5. Antiepileptics / Anticonvulsants 17
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Diazepam injection, 5mg/ml in 2-ml (intravenous or rectal) y y - Carbamazepine tablet, 100 mg, 200 mg y - - Phenobarbital@ tablet, 15 mg, 30 mg@ y - - Phenytoin capsule or tablet, 25 mg, 50 mg, 100 mg injection, 50 mg/ml in 5-ml vial y - - Magnesium sulphate * @ injection, 50 mg/ml in 2 ml ampoule y@ y@ y@ * For use in eclampsia and severe pre-clampsia and not for other convulsant disorders 6. Anti-infective Medicines 6.1 Anthelmintics 6.1.1 Intestinal Anthelmintics Albendazole@ tablet (chewable), 400 mg y@ y@ y@ Complementary Praziquantel tablet, 150 mg, 600 mg - - - 6.1.2 Antifilarials Diethylcarbamazine tablet,50 mg, 100 mg (dihydrogen citrate) y y y 6.2 Antibacterials 6.2.1 Beta-lactum Medicines Amoxicillin@ capsule, 500mg (as trihydrate); dispersible tablet, 125 mg, 250 mg (as trihydrate) y@ y@ y@ Ampicillin powder for injection, 500mg (as sodium salt) in vial y (C) - - Benzathine benzylpenicillin powder for injection, 1 200 000 IU in vial y(C) - - Benzylpenicillin injection, 300 mg (0.5 m IU), 600 mg (1 m IU) (Penicillin G) (as sodium or potassium salt) in vial y - - Cloxacillin capsule, 250 mg, 500 mg y - - powder for oral liquid, 125 mg / 5ml y - - injection, 250 mg, 500 mg (as sodium salt) in vial y - - Complementary Cefixime# capsule, 200 mg y(C) - - #Only listed for single-dose treatment of uncomplicated ano-genital gonorrhoea 6.2.2 Other Antibacterials Azithromycin* capsule or tablet 250 mg, 500 mg; y(C) y(C) y (C) oral liquid, 200 mg /5ml. y(C) y(C) y(C) *Only listed for single-dose treatment of genital Chlamydia trachomatis and trachoma. Chloramphenicol@ @capsule, 250 mg, 500 mg; y - - @oral liquid, 125 mg / 5ml (as palmitate), y - - powder for injection, 1g (as sodium succinate) in vial y - - Ciprofloxacin @ tablet, 250 mg,@ 500 mg (as hydrochloride) y@ y@ y Doxycycline capsule, 100mg (as hydrochloride) y y y Gentamycin@ injection, 10 mg, 40 mg / ml @in 2-ml vial y@ y@ y@ Metronidazole@ @tablet, 200 mg, 400 mg y@ y@ y@ @oral suspension, 200 mg (as benzoate) / 5ml y@ y@ y@ injection, 500 mg in 100-ml vial y(C) - - Nitrofurantoin tablet, 100 mg y - - Sulfamethoxazole+Trimethoprim@ dispersible tablet, 100mg+20 mg, 200 mg+ 40 mg; tablet 400 mg + 80 mg, 800 mg+ 160 mg y@ y@ y@ Complementary Erythromycin tablet, 250 mg (stearate); oral suspension, 250 mg / 5ml (stearate) y - - Nalidixic acid tablet, 250 mg, 500 mg y - - 6.2.3 Antileprosy Medicines Clofazimine capsule, 50 mg, 100 mg y y - Dapsone tablet, 50 mg, 100 mg y y - 18
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Rifampicin capsule or tablet 150 mg, 300 mg y y - 6.2.4 Antitubercular Medicines Ethambutol tablet, 400 mg (hydrochloride) y - - Isoniazid tablet, 100 mg, 300 mg y - - Isoniazid+Ethambutol tablet, 150mg + 400mg y - - Rifampicin capsule or tablet, 150mg, 300mg y - - Rifampicin+isoniazid tablet, 60 mg+ 30 mg, 150mg + 75 mg y - - Rifampicin+isoniazid+ethambutol tablet, 150 mg+ 75 mg+2 75 mg y - - Rifampicin+isoniazid+pyrazinamide tablet, 60 mg+ 30 mg+150 mg y - - Rifampicin+isoniazid+pyrazinamide+ ethambutol tablet, 150 mg+ 75 mg + 400 mg + 275 mg y - - Streptomycin powder for injection, 1 g (as sulfate) in vial y - - Complementary list: Second-line medicines for the treatment of multi-drug resistant tuberculosis (MDR-TB) - to be made available only in specialised centres adhering to standard treatment protocol. Cycloserine tablet, 250 mg - - - Ethionamide tablet, 250 mg - - - Kanamycin powder for injection 1 g in vial - - - Ofloxacin tablet, 200 mg - - - p-aminosalicylic acid (PAS) granules, 4 g in sachet; tablet 500 mg - - - Pyrazinamide tablet, 400mg - - - 6.3 Antifungal Medicines Clotrimazole cream 1%, pessary 100 mg y(C) - - Fluconazole capsule or tablet, 150 mg y(C) y(C) - 6.4 Antiprotozoal Medicines 6.4.1 Antiamoebic and Antigiardiasis Medicines Metronidazole@ tablet, 200mg, 400mg; oral liquid, 200 mg (as benzoate) / 5 ml. y@ y@ y@ Complementary Tinidazole tablet, 500mg y - - 6.4.2 Antileishmaniasis Medicines Miltefosine capsule, 50 mg y - - Complementary Amphotericin B powder for injection, 50 mg in vial y - - Sodium stibogluconate injection, 100mg/ml y - - 6.4.3 Antimalarial Medicines Artesunate injection, ampoules, containing 60 mg anhydrous artesunic acid with a separate ampoule of 5% sodium bicarbonate solution; tablet 50 mg y - - Artemether* oily injection, 80 mg/ml in 1-ml ampoule. y - - * For use in the management of severe malaria. Artemether+lumefantrine# tablet, 20 mg+ 120 mg y - - # Not recommended in the first trimester of pregnancy or in children below 5 kg. Chloroquine tablet, 150 mg base (as phosphate or sulfate); oral liquid, 50 mg / 5ml (as phosphate or sulfate); injection, 40mg /ml in 5- ml ampoule (as phosphate, sulfate or hydrochloride) y - - Primaquine tablet, 7.5 mg, 15 mg (as diphosphate) y - - Sulfadoxine + Pyrimethamine tablet, 500 mg + 25 mg y - - Complementary Quinine tablet, 300 mg (as bisulfate or sulfate) injection, 300mg (as dihydrochloride)/ ml in 2-ml ampoule. y - - 7. Medicines Affecting the Blood 7.1 Antianaemia Medicines 19
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Ferrous salt (Ferrous sulfate)* tablet, equivalent to 60 mg Iron; y y y oral liquid, equivalent to 25 mg iron/ ml y y y Ferrous salt (sulfate)*+Folic acid@ tablet, equivalent to 60 mg Iron+ 400 mcg Folic acid. y@ y@ y@ Folic acid tablet, 5mg y - - *Other salts of Iron may be used 7.2 Medicines Affecting Coagulation Complementary Phytomenadione injection, 10mg/ml in 5-ml ampoule - - - 8. Blood Products and Plasma Substitutes Polygeline injectable solution, 3.5% y (C) - - 9. Cardiovascular Medicines 9.1 Antianginal Medicines Complementary Glyceryl trinitrate tablet (sublingual), 500 mcg y - - 9.2 Antihypertensive Amlodipine tablet, 5 mg y y(C) - Atenolol@ tablet, 50 mg y@ y@ - Hydrochlorothiazide tablet, 25 mg y y - Nifedipine capsule or tablet, 10 mg y y - Complementary Enalapril tablet, 5 mg y - - 9.3 Medicines Used in Heart Failure Digoxin tablet, 62.5 mcg, 250 mcg y - - 10. Dermatological Medicines 10.1 Antifungal Medicines Benzoic acid + Salicylic acid@ ointment or cream, 6% + 3% y@ y@ y Clotrimazole ointment or cream, 2% y - - 10.2 Anti-infective Medicines Povidone iodine@ solution, 5% y@ y@ y@ Silver sulfadiazine cream, 0.2% y y - Complementary Gentian violet aqueous solution 1% y y y (methylrosanilinium chloride) 10.3 Anti-inflammatory and Antipruritic Medicines Betamethasone ointment or cream, 0.1% (as valerate) y - - Complementary Calamine lotion@ lotion, 15% y@ y@ y@ Hydrocortisone ointment or cream, 1% (acetate) y - - 10.4 Scabicides and Pediculicides Lindane@ cream or lotion, 1% y@ y@ y@ (Gamma benzene hexachloride) Complementary Permethrin lotion 1%, cream 5% y y y 11. Disinfectants and Antiseptics 11.1 Antiseptics 20
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Chlorhexidine solution, 5% (digluconate) for dilution y y y Povidone iodine@ solution, 5% y@ y@ y@ Rectified spirit liquid y y y 11.2 Disinfectants Formaldehyde solution, 3% y - - Cetrimide solution, 20% for dilution y y y Complementary Gentian violet aqueous solution 1% y y y (methylrosanilinium chloride) Chlorine base compound powder (0.1% available chlorine) for solution y y y 12. Diuretics Furosemide@ tablet, 40 mg y@ y - injection, 10 mg/ml in 2-ml ampoule y y - Hydrochlorothiazide tablet, 25mg y y - Mannitol injectable solution, 20% y(C) - - Complementary Spironolactone tablet, 25mg y - - 13. Gastrointestinal Medicines 13.1 Antacids and Other Anti-ulcer Medicines Dried aluminium hydroxide gel + tablet, 250mg +250 mg y@ y@ y@ Magnesium hydroxide@ Ranitidine tablet, 150 mg (as hydrochloride) y y - Complementary Omeprazole tablet, 20 mg y - - 13.2 Antiemetic Medicines Metoclopramide tablet, 10 mg (hydrochloride) y y y @injection, 5 mg (hydrochloride)/ml in 2-ml ampoule y@ y@ y@ Promethazine@ tablet, 25 mg (as theoclate) y@ y@ y 13.3 Laxatives Bisacodyl tablet, 10mg y y y 13.4 Medicines used in Diarrhoea 13.4.1 Oral Rehydration Oral rehydration salts*@ Sachet containing: Dextrose, anhydrous 13.5 g, Sodium chloride 2.6 g, Potassium chloride 1.5 g, Trisodium citrate dihydrate 2.9 g, appropriate flavour q.s. Dissolved to produce 1 litre, provides Dextrose 75 mEq, sodium 75 mEq or mmol/l, chloride 65 mEq or mmol/l, potasium 20 mEq or mmol/l, citrate 10 mmol/l and osmolarity 245 mOsm/l y@ y@ y@ * In case of cholera a higher concentration of sodium may be required. 13.4.2 Medicine for Diarrhoea in Children Zinc sulfate dispersible tablet, equivalent to Zinc 20 mg (scored) y y y 13.5 Antispasmodic Medicines Hyoscine butylbromide @ @tablet, 10 mg, 20 mg; y@ y@ y@ injection, 20mg / ml in 1- ml ampoule y - - 14. Hormones, Other Endocrine Medicines and Contraceptives 14.1 Adrenal Hormones and Synthetic Substitutes Dexamethasone tablet, 500 mcg y y y @injection, 4 mg/ml in 1-ml ampoule y@ y@ y 21
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Hydrocortisone powder for injection, 100 mg in vial y - - Prednisolone tablet, 5 mg, 10 mg y - - 14.2 Contraceptives 14.2.1 Oral Harmonal Contraceptives Ethinylestradiol + Levonorgestrel tablet, 30 mcg +150 mcg y y y Ethinylestradiol + Norethisterone tablet, 35 mcg + 1.0 mg y y y Levonorgestrel tablet, 750 mcg (pack of two), 1.5 mg y y y 14.2.2 Injectable Hormonal Contraceptive Medroxyprogesterone acetate depot injection, 150 mg / ml in 1-ml vial y y y 14.2.3 Intrauterine Devices Copper-containing devices y y - 14.2.4 Barrier Methods Condoms y y y 14.3 Insulins and Other Atidiabetic Agents Glibenclamide tablet, 2.5mg, 5 mg y - - Insulin - injection (soluble) injection, 40 IU / ml in 10-ml vial y - - Metformin tablet, 500 mg (hydrochloride) y - - 15. Immunologicals 15.1 Sera and immunoglobulins Anti-D immunoglobulin (human) injection, 250 mcg in single dose vial y - - Antirabies hyperimmune serum injection, 1000 IU in 5-ml ampoule y - - Polyvenum antisnake serum injection in vial y - - Tetanus antitoxin injection, 1 000 IU, 3 000 IU in vial y - - Tetanus immunoglobulin (human) injection, 500 IU in vial y - - 15.2 Vaccines 15.2.1 For universal immunization BCG (freeze-dried) vaccine y - - Diphtheria-pertussis-tetanus-Hepatitis B vaccine y - - Diphtheria-pertussis-tetanus-Hepatitis B vaccine y - - -Haemophilus influenza b Measles vaccine (live attenuated) y - - Poliomyelitis (Oral) vaccine y - - Tetanus toxoid (Tetanus vaccine) vaccine y - - 15.2.2 For specific groups of individuals Hepatitis B vaccine vaccine y - - Influenza vaccine y - - Japanese Encephalitis SA 14-14-2 strain freeze dried vaccine y - - Meningococcal vaccine vaccine y - - Mumps vaccine y - - Rabies vaccine vaccine y - - Rubella vaccine y - - Typhoid vaccine y - - Yellow fever vaccine vaccine y - - 16. Muscle relaxants (peripherally acting) and cholinesterase inhibitors Complementary Neostigmine injection 500 mcg, 2.5 mg in 1-ml ampoule - - - 17. Ophthalmological, ear, nose and throat preparations 17.1 Ophthalmological preparations 17.1.1 Anti-infective agents Chloramphenicol@ applicap 1% y@ y@ y@ 22
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Ciprofloxacin@ eye/ear drpos, 0.3% (hydrochloride) y@ y@ y@ Ciprofloxacin@ eye ointment 0.3% (hydrochloride) y@ y@ - Complementary Tetracycline eye ointment, 1% (hydrochloride) y y y 17.1.2 Miotics and Antiglaucoma Medicines Acetazolamide tablet, 250 mg y - - 17.2. Ear, Nose and Throat Preparations Bismuth Iodoform Paraffin solution - - - Chloramphenicol ear drops, 5% y y y Ichthammol+Glycerine ear drop - - - Sodium bicarbonate +glycerine ear drop - - - 17.3 Dental Clove oil@ oil y@ y@ y@ 18. Oxytocics and Antioxytocics 18.1 Oxytocics Methylergometrine tablet, 200mcg (maleate) y y - injection, 200mcg 1-ml ampoule y y - Oxytocin@ injection, 5 IU/ml in 1-ml ampoule y@ y@ y@ Complementary Mesoprostol vaginal or oral tablet, 25 mcg y - - Mifepristone*+misoprostol tablet, 200mg+ 200 mcg y - - * Combi-pack, containing 1 tablet of mifepristone and 4 tablets of misoprostol. Requires close medical supervision. For health facilities approved for abortion services only. 18.2 Anti-oxytocics Complementary Isoxsuprine injection, 5mg/ml - - - 19. Psychotherapeutic medicines Alprazolam@ tablet, 0.25 mg y - - Amitriptyline tablet,10 mg, 25 mg (hydrochloride) y - - Chlorpromazine tablet,50 mg (hydrochloride) y - - injection, 25 mg (hydrochloride)/5ml in 2-ml ampoule y - - Diazepam tablet 5 mg y - - 20. Medicines Acting on the Respiratory Tract 20.1 Antiasthmatic and Medicines for Chronic Obstructive Pulmonary Disease Aminophylline tablet, 100 mg y y y@ Epinephrine injection, 1 mg in 1-ml ampoule. y y - Salbutamol@ tablet, 4 mg @ (as sulfate); y@ y@ y oral liquid, 2mg (as sulfate)/5ml; y y y rotacap, 200 mcg (as sulfate) per dose y - - Complementary Theophylline Tablet, 300 mg y y y 21. Solution Correcting Water, Electrolyte and Acid Base Disturbances 21.1 Oral Oral rehydration salts@ Sachet containing: Dextrose, anhydrous 13.5 g, Sodium chloride 2.6 g, Potassium chloride 1.5 g, Trisodium citrate dihydrate 2.9 g, appropriate flavour q.s. Dissolved to produce 1 litre, provides Dextrose 75 mEq, sodium 75 mEq or mmol/l, chloride 65 mEq or mmol/l, potasium 20 mEq or mmol/l, citrate 10 mmol/l and osmolarity 245 mOsm/l y@ y@ y@ 23
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 21.2 Parenteral Compound solution of Sodium lactate injectable solution y@ y@ y@ (Ringer's Lactate)@ Glucose @ injectable solution, 5% isotonic, y y y 50% hypertonic y - - Glucose with Sodium chloride injectable solution, 5% glucose, 0.9% sodium chloride y - - Potassium chloride injection, 11.2% in 20ml ampoule y - - Sodium chloride@ injectable solution, 0.9% isotonic y@ y@ y Sodium bi-carbonate injection, 1.4%, 8.4% solution y - - 21.3 Miscellaneous Water for injection 5-ml ampoule y y - 22. Vitamins and Minerals Calcium gluconate injection, 100 mg / ml in 10-ml ampoule - - - Pyridoxine tablet, 25mg (hydrochloride) y - - Retinol +DL-alpha-tocopherol Retinol (as palmitate)+DL-alpha-tocopherol or tocopheryl acetate, soft gel capsule, 200 000 IU+ 40 IU, 100 000 IU+ 20 IU, 50 000 IU+ 20 IU y y y Vitamin B complex@ tablet containing: thiamine mononitrate 5 mg, riboflavin 5 mg, pyridoxine hydrochloride1.5 mg, nicotinamide 50 mg, calcium pantothenate 25 mg. y@ y@ y@ ******* Index National List of Essential Medicines A Amoxicillin 3 Abacavir (ABC) 5 Amphotericin B 6 Acenocoumarol 8 Ampicillin 3 Acetazolamide 13 Anti-D immunoglobulin (human) 12 Acetylcysteine 2 Antirabies hyperimmune serum 12 Acetylsalicylic acid see Aspirin Artemether 6 Aciclovir 5,13 Artesunate 6 Adrenaline see Epinephrine Ascorbic acid 16 Albendazole 3 Aspirin 1,9 Albumin, human 8 Atenolol 8 Allopurinol 2 Atorvastatin 9 Alprazolam 14 Atropine 1,2,13 Aluminium hydroxide gel, dried 10 Azithromycin 3 Amidotrizoate 9 Aminophylline 15 B Amitriptyline 15 Barium sulfate 9 24
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 BCG vaccine 12 Clomipramine 15 Beclomethasone 15 Clotrimazole 5,9 Benzathine benzylpenicillin 3 Clove oil 14 Benzoic acid 9 Cloxacillin 3 Benzoyl peroxide 9 Coal tar 9 Benzylpenicillin 3 Colchicine 2 Betamethasone 9 Compound solution of sodium lactate 15 Bicalitumide 7 Condoms 11 Bisacodyl 10 Copper-containing devices 11 Bismuth Iodoform Paraffin 13 Cromoglicate see Sodium Bleomycin 7 cromoclicate Bupivacaine 1 Cyclophosphamide 6 Cycloserine 4 Cytarabine 6 D C Dacarbazine 7 Calamine lotion 9 Dactinomycin 7 Calcium folinate 6 Dapsone 4 Calcium gluconate 2,16 Daunorubicin 7 Calcium leucovorin Deferoxamine 2 see Calcium folinate Desmopressin 12 Calcium pantothenate see Vitamin B complex Dexamethasone 2,7,11 Captopril 8 Dextrose see Oral Rehydration Salt Carbamazepine 3 Diazepam 1,3,14 Carbidopa see Levodopa Diclofenac Sodium 1 Carbimazole 12 Didanosine (ddI) 5 Carboplatin 7 Diethylcarbamazine 3 Cefazolin 3 Digoxin 8 Cefixime 3 Diloxanide 5 Cefotaxime 3 Dimercaprol 2 Ceftriaxone 4 Diphtheria-Tetanus-Pertussis- Cetrimide 10 Hepatitis B vaccine 12 Charcoal, activated 2 Diphtheria-Tetanus-Pertussis- Chlorambucil 7 Hepatitis B-Haemophilus type b 12 Chloramphenicol 4 Disopyramide 8 Chloramphenicol eye applicap 13 Disulfiram 15 Chloramphenicol ear drop13 DL-alpha-tocopherol 16 Chlordiazepoxide 14 Dobutamine 8 Chlorhexidine solution 10 Dopamine 2 Chlorhexidine gargle 14 Doxorubicin 6 Chlorine based compound 10 Doxycycline 4 Chloroquine 6 Chlorpheniramine 2 E Chlorpromazine 14 Efavirenz (EFV or EFZ) 5 Ciclosporin 6 Enalapril 8 Ciprofloxacin 4 Ephedrine 1 Ciprofloxacin eye/ear drops 13 Epinephrine 1,2,15 Ciproflpxacin eye ointment 13 Epirubicin 7 Cisplatin 6 Ergocalciferol 16 Clofazimine 4 Ergotamine 6 Clomifene 12 Erythromycin 4 25
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Ethambutol 4 Indinavir (IDV) 5 Ethinylestradiol 12 Influenza vaccine 13 Ethionamide 4 Insulin injection 12 Ethyl alcohol 15 Interferon 7 Etoposide 6 Intermediate acting insulin 12 Intraperitoneal dialysis solution 14 F Iodine see Lugol's iodine and Factor IX complex 8 Povidone iodine Factor VIII concentrate 8 Iohexol 9 Ferrous salt 7 Ipratropium bromide 15 Fluconazole 5 Iron Dextran 7 Fludrocortisone 11 Isoflurane 1 Fluorescein 9 Isoniazid 4 Fluorouracil 6 Isoprenaline 8 Fluoxetine 14 Isoxsuprine 14 Fluphenazine 14 J Flutamide Japanese Encephalitis vaccine 13 Folic acid 7 K Formaldehyde 10 Kanamicin 5 Furosemide 10 Ketamine 1 G L Gamma benzene hexachloride Lactulose 10 see Lindane L-Asparaginase 6 Gentian violet 10 Lamivudine (3TC) 5 Gentamicin 4 Levodopa 7 Gentamicin eye drops 13 Levonorgestrel 11 Glibenclamide 12 Levothyroxine 12 Glipizide 12 Lidocaine see Lignocaine Glucose injectable 15 Lignocaine 1,13 Glutaraldehyde 10 Lindane 9 Glycerine ear drop see Ichthammol or Lithium carbonate 14 Sodium bicarbonate Lomustine 7 Glyceryl trinitrate 8 Lopinavir 5 Granulocyte Colony Stimulating Lugol's iodine 12 Factor 6 Lumefantrine 6 H M Haloperidol 14 Magnesium hydroxide 10 Halothane 1 Magnesium sulfate injection 3 Heparin sodium 7 Magnesium sulfate powder 10 Hepatitis A vaccine 13 Mannitol 10 Hepatitis B vaccine 13 Measles vaccine 12 Hydrochlorothiazide 8,10 Medroxyprogesterone acetate 11,12 Hydrocortisone 2,7,11 Meglumine iotroxate 9 Hydrocortisone ointment 9 Melphalan 6 Hydroxy urea 6 Meningococcal vaccine 13 Hyoscine butylbromide 11 Mensa 6 I Mercaptopurine 6 Ibuprofen 1 Metformin 12 Ichthammol 14 Methotrexate 2,7 Idoxuridine 6 Methylene blue 2 Ifosfamide 6 Methylergometrine 14 26
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Mifepristone 14 Polygeline 8 Misoprostol 14 Polyvenum antisnake serum 12 Methadone 15 Potassium ferric hexacyano-ferrate Methylrosanilinium chloride see Prussian blue see Gentian violet Potassium chloride see Oral Rehydration Salt Methylthioninium chloride Potassium chloride injection 15 see Methylene blue Povidone Iodine 10 Metoclopramide 10 Pralidoxime 2 Metronidazole 4,5 Praziquantel 3 Miltefosine 5 Prazosin 8 Mitomycin 7 Prednisolone 2,7,11 Mitoxantrone 7 Prednisolone eye drop 13 Morphine 2 Primaquine 6 Mumps vaccine 13 Procainamide 8 N Procaine benzylpenicillin 3 Nalidixic acid 4 Promethazine 10 Naloxone 2 Propofol 1 Nelfinavir (NFV) 5 Propranolol 6 Neostigmine 13 Protamine sulfate 8 Nevirapine (NVP) 5 Pyrazinamide 5 Niclosamide 3 Pyridoxine 16 Nicotinamide see Vitamin B Complex Pyrimethamine see Sulfadoxine Nifedipine 8 Prussian blue 2 Nitrofurantoin 4 Q Nitrous oxide 1 Quinine 6 Norethisterone 11,12 R Nystatin 5 Ring pessary 11 O Ringer's lactate solution see Compound Ofloxacin 5 solution of sodium lactate Omeprazole 10 Ritonavir 5 Ondansetron 7 Rabies vaccine 12 Oral rehydration salts 11,15 Ranitidine 10 Oxygen 1 Rectified spirit 10 Oxymetazoline 14 Retinol 16 Oxytocin 14 Riboflavin 16 P Rifampicin 4 Pancuronium bromide 13 Rubella vaccine 13 Para Amino Salicylic Acid (PAS) 5 S Paracetamol 1,6 Salbutamol 15 Paradehyde 3 Salicylic acid 9 Penicillin G see Benzylpenicillin Saquinavir (SQV) 5 PenicillinV see Phenoxymethylpenicillin Selenium sulfide 9 Permethrin 9 Silver sulfadiazine 9 Pethidine 2 Sodium bicarbonate injection15 Pheniramine 2 Sodium bicarbonate +Glycerine Phenobarbital 3 ear drop 14 Phenoxymethylpenicillin 3 Sodium calcium edetate 2 Phenytoin 3 Sodium chloride see Oral Rehydration Salt Phytomenadione 8 Sodium chloride injection15 Pilocarpine 13 Sodium cromoclicate 15 Poliomyelitis vaccine 12 Sodium nitrite 2 27
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Sodium nitroprusside 8 Triamterene 10 Sodium stibogluconate 6 Trihexyphenidyl 7 Spironolactone 10 Trimethoprim see Sulfamethoxazole Stavudine (d4T) 5 Trisodium citrate see Oral Rehydration Salt Streptokinase 9 Tuberculin, purified protien derivative Streptomycin 4 (PPD) injection 12 Sulfadoxine 6 Typhoid vaccine 13 Sulfamethoxazole 4 V Sulphasalazine 10 Valproic acid 3 Suxamethonium chloride 13 Vecuronium bromide 13 T Verapamil 8 Tamoxifen 7 Vinblastine 7 Tenofovir disoproxil fumarate (TDF) 5 Vincristine 7 Testosterone 11 Vitamin B complex 16 Tetanus antitoxin 12 W Tetanus immunoglobulin (human) 12 Warfarin 8 Tetanus toxoid 12 Water for injection 15 Tetracaine 13 Tetracyline eye ointment 13 Y Theophylline 15 Yellow fever vaccine 13 Thiamine see Vitamin B complex Z Thiopental 1 Zidovudine (ZDV or AZT) 5 Thioridazine 14 Zinc oxide 14 Timolol 13 Zinc sulfate 11 Tinidazole 5 List of Essential Medicines for District Hospital A Atropine 18 Acetazolamide 23 Azithromycin 18 Acetylcysteine 18 B Acetylsalicylic acid see Aspirin BCG vaccine 22 Adrenaline see Epinephrine Benzathine benzylpenicillin 18 Albendazole 18 Benzoic acid 20 Allopurinol 17 Benzylpenicillin 18 Alprazolam 23 Betamethasone 21 Aluminium hydroxide gel, dried 21 Bisacodyl 21 Aminophylline 24 Bismuth Iodoform Paraffin 23 Amitriptyline 23 C Amlodipine 20 Calamine lotion 21 Amoxicillin 18 Calcium gluconate 24 Amphotericin B 19 Calcium pantothenate see Vitamin B complex Ampicillin 18 Carbamazepine 18 Anti-D immunoglobulin (human) 22 Cefixime 18 Antirabies hyperimmune serum 22 Cetrimide 21 Artemether 20 Charcoal, activated 18 Artesunate 20 Chloramphenicol 19 Aspirin 17 Chloramphenicol eye applicap 23 Atenolol 20 Chloramphenicol ear drop 23 28
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Chlorhexidine solution 21 Glibenclamide 22 Chlorine based compound 21 Glucose injectable 24 Chloroquine 20 Glycerine ear drop see with Ichthammol or Chlorpheniramine 17 Sodium bicarbonate Chlorpromazine 23 Glyceryl trinitrate 20 Ciprofloxacin 19 H Ciprofloxacin eye/ear drops 23 Halothane 17 Ciproflpxacin eye ointment 23 Hepatitis B vaccine 23 Clofazimine 19 Hydrochlorothiazide 20,21 Clotrimazole 19,20 Hydrocortisone 17,22 Clove oil 23 Hydrocortisone ointment 21 Cloxacillin 18 Hyoscine butylbromide 22 Colchicine 17 Ibuprofen 17 Condoms 22 Ichthammol 23 Compound solution of Sodium lactate 24 Ifosfamide 6 Copper-containing devices 22 Influenza vaccine 23 Cycloserine 19 Insulin injection 22 D Iodine see Lugol's iodine and Dapsone 19 Povidone iodine Dexamethasone 22 Isoniazid 19 Dextrose see Oral Rehydration Salt Isoxsuprine 23 Diazepam 18,23 J Diclofenac Sodium 17 Japanese Encephalitis vaccine 23 Diethylcarbamazine 18 K Digoxin 20 Kanamicin 19 Diphtheria-Tetanus-Pertussis- Ketamine 17 Hepatitis B vaccine 22 L Diphtheria-Tetanus-Pertussis- Levonorgestrel 22 Hepatitis B-Haemophilus type b 22 Lidocaine see Lignocaine DL-alpha-tocopherol 24 Lignocaine 17 Dopamine 18 Lindane 21 Doxorubicin Lumefantrine 20 Doxycycline 19 M E Magnesium hydroxide 21 Enalapril 20 Magnesium sulfate injection 18 Epinephrine 17,18,24 Mannitol 21 Erythromycin 19 Measles vaccine 22 Ethambutol 19 Medroxyprogesterone acetate 22 Ethinylestradiol 22 Meningococcal vaccine 23 Ethionamide 19 Metformin 22 F Methylergometrine 23 Ferrous salt 20 Mifepristone 23 Fluconazole 19 Misoprostol 23 Folic acid 20 Methylrosanilinium chloride Formaldehyde 21 see Gentian violet Furosemide 21 Metoclopramide 21 Metronidazole 19 G Miltefosine 19 Gamma Benzene hexachloride Mumps vaccine 23 see Lindane N Gentian violet 21 Nalidixic acid 19 Gentamicin 19 Naloxone 18 29
Draft: National List of Essential Medicines - Nepal, Fourth Revision, 2009 Neostigmine 23 Sodium bicarbonate +Glycerine Nicotinamide see Vitamin B Complex ear drop 23 Nifedipine 20 Sodium chloride see Oral Rehydration Salt Nitrofurantoin 19 Sodium chloride injection 24 Norethisterone 22 Sodium stibogluconate 19 O Spironolactone 21 Ofloxacin 19 Streptomycin 19 Omeprazole 21 Sulfadoxine 20 Oral rehydration salts 22,24 Sulfamethoxazole 19 Oxygen 17 T Oxytocin 23 Tetanus antitoxin 22 P Tetanus immunoglobulin (human) 22 Para Amino Salicylic Acid (PAS) 19 Tetanus toxoid 22 Paracetamol 17 Tetracyline eye ointment 23 Penicillin G see Benzylpenicillin Theophylline 24 Permethrin 21 Thiamine see Vitamin B complex Pethidine 17 Thiopental 17 Pheniramine 18 Tinidazole 19 Phenobarbital 18 Trimethoprim see Sulfamethoxazole Phenytoin 18 Trisodium citrate see Oral Rehydration Salt Phytomenadione 20 Tuberculin, purified protien derivative Poliomyelitis vaccine 22 (PPD) injection Polygeline 20 Typhoid vaccine 23 Polyvenum antisnake serum22 V Potassium chloride see Oral Rehydration Salt Vitamin B complex 24 Potassium chloride injection 24 W Povidone Iodine 20,21 Water for injection 24 Pralidoxime 18 Y Praziquantel 18 Yellow fever vaccine 23 Prednisolone 18,22 Primaquine 20 Z Promethazine 21 Zinc sulfate 22 Pyrazinamide 19 Pyridoxine 24 Pyrimethamine see Sulfadoxine Q Quinine 20 R ************************ Ringer's lactate solution see Compound solution of sodium lactate Rabies vaccine 23 Ranitidine 21 Rectified spirit 21 Retinol 24 Riboflavin see Vitamin B complex Rifampicin 19 Rubella vaccine 23 S Salbutamol 24 Salicylic acid 20 Silver sulfadiazine 20 Sodium bicarbonate injection 24 30
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