JCEM THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

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JCEM THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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                ENDOCRINOLOGY
                & METABOLISM
                THE JOURNAL
                OF CLINICAL

                JCEM
N U M BER 2
VOLUME 106
February 2021

                                                                                                                 INT’L
                                            February 2021                 VOLUME 106              N U M BER 2
JCEM THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
JCEM
                                       THE JOURNAL
                                       OF CLINICAL
                                       ENDOCRINOLOGY
                                       & METABOLISM

                                                                            PUBLICATIONS CORE COMMITTEE
                                                                            Daniel I. Spratt, Chair
                                                                            Amita Bansal

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                                                                            Arthur Gutierrez-Hartmann
                                                                            Smita Jha
                                                                            George J. Kahaly
MISSION STATEMENT OF THE ENDOCRINE SOCIETY                                  Ana Claudia Latronico
We unite, lead, and grow the endocrine community to accelerate              Zhenqi Liu
scientific breakthroughs and improve health worldwide.                      Sue Moenter
                                                                            Stephanie T. Page
APRIL 2020 – MARCH 2021                                                     Matthew D. Ringel
                                                                            Hironobu Sasano
BOARD OF DIRECTORS                                                          Gary D. Hammer, Ex Officio (President)
Gary D. Hammer, President                                                   Carol H. Wysham, Ex Officio (President-Elect)
Carol H. Wysham, President-Elect                                            Dolores M. Shoback, Ex Officio (Secretary/Treasurer)
E. Dale Abel, Immediate Past President
Dolores M. Shoback, Secretary/Treasurer
Henry Anhalt
Richard J. Auchus
Samantha F. Butts
Ann Danoff
Ghada El-Hajj Fuleihan
Whitney S. Goldner
Ruth A. Keri
Kathryn A. Martin
John D.C. Newell-Price
Stephen M. Rosenthal
Joy Y. Wu

Jenny A. Visser, Ex Officio (Nominating Committee Chair)
Lindsey S. Trevino, Ex Officio (Early Career Director)

On the Cover: Cross section of a human uterine gland. The epithelium is columnar simple and shows a mitotic cell near the lumen. Credit: Jose Luis
Calvo/Science Source.

J Clin Endocrinol Metab, February 2021, 106(2):1A                                                                 https://academic.oup.com/jcem       1A
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JCEM
                                                                                                                            THE JOURNAL
February 2021 ● VOLUME 106 ● NUMBER 2                                                                                       OF CLINICAL
                                                                                                                            ENDOCRINOLOGY
EDITORIAL BOARD                                                                                                             & METABOLISM

EDITOR-IN-CHIEF                                     Karen S.L. Lam, MD, FHKAM(Med),               Michael S. Boyne, MD
                                                    FHKCP, FRCP(Edin, Lond), FRACP                The University of the West Indies
Paul M. Stewart, MD, FRCP, FMedSci                  The University of Hong Kong                   Kingston, Jamaica
University of Leeds                                 Hong Kong
Leeds, United Kingdom                                                                             Sonia Caprio, MD
                                                    Nicola Napoli, MD, PhD                        Yale University School of Medicine
                                                    University Campus Bio-Medico                  New Haven, Connecticut, USA
DEPUTY EDITORS
                                                    Rome, Italy
                                                                                                  Ada S. Cheung, MBBS (Hons),
Ursula B. Kaiser, MD
                                                    Genevieve Neal-Perry, MD, PhD                 FRACP, PhD
Harvard Medical School
                                                    University of Washington School of Medicine   Austin Health and The University of Melbourne
Boston, Massachusetts, USA
                                                    Seattle, Washington, USA                      Melbourne, Australia

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Raghavendra G. Mirmira, MD, PhD
                                                    Elizabeth N. Pearce, MD                       Mirjam Christ-Crain, MD, PhD
The University of Chicago
                                                    Boston University Medical Center              University of Basel
Chicago, Illinois, USA
                                                    Boston, Massachusetts, USA                    Basel, Switzerland

ASSOCIATE EDITORS                                   Mark Sherlock, MB (Hons), BCh, BAO,           Adi Cohen, MD, MHSc
                                                    MRCPI, MD, PhD                                Columbia University
Takashi Akamizu, MD, PhD                            Royal College of Surgeons in Ireland and      New York, New York, USA
Wakayama Medical University                         Beaumont Hospital
Wakayama, Japan                                     Dublin, Ireland                               Cosimo Durante, MD, PhD
                                                                                                  Sapienza Università di Roma
Felix Beuschlein, MD                                Hirotaka Watada, MD, PhD                      Rome, Italy
University Hospital Zurich                          Juntendo University
Zurich, Switzerland                                 Tokyo, Japan                                  Elif I. Ekinci, MBBS, FRACP, PhD
                                                                                                  University of Melbourne
Ellen E. Blaak, PhD                                                                               Melbourne, Australia
                                                    EDITORIAL BOARD
Maastricht University
Maastricht, The Netherlands                         Erik K. Alexander, MD                         Tobias Else, MD
                                                    Brigham & Women’s Hospital,                   University of Michigan
Stephanie T. Chung, MBBS (Hons), FAAP               Harvard Medical School                        Ann Arbor, Michigan, USA
National Institute of Diabetes, Digestive and
                                                    Boston, Massachusetts, USA
Kidney Diseases                                                                                   Pamela U. Freda, MD
National Institutes of Health                       Caroline M. Apovian, MD                       Columbia University
Bethesda, Maryland, USA                             Boston University School of Medicine          New York, NY, USA
                                                    Boston, Massachusetts, USA
Joshua N. Farr, PhD                                                                               Julia H. Goedecke, PhD
Mayo Clinic College of Medicine                                                                   South African Medical Research Council
                                                    Natasha M. Appelman-Dijkstra, MD, PhD
Rochester, Minnesota, USA                           Leiden University Medical Center              Cape Town, South Africa
                                                    Leiden, The Netherlands
Mônica Gadelha, MD, PhD                                                                           Mathis Grossmann, MD, PhD, FRACP
Universidade Federal do Rio de Janeiro                                                            University of Melbourne
                                                    Muthuswamy Balasubramanyam, PhD,
Rio de Janeiro, Brazil                              FAMS, MNASc, FAPASc, FASCh                    Heidelberg, Australia
                                                    Madras Diabetes Research Foundation (MDRF)
David J. Handelsman, MB BS, PhD,                                                                  S. Mitchell Harman, MD, PhD
                                                    Chennai, India
FRACP, FAHMS                                                                                      University of Arizona College of Medicine and the
ANZAC Research Institute, University of Sydney                                                    Phoenix VA Health Care System
                                                    Irina Bancos, MD
Sydney, Australia                                   Mayo Clinic                                   Phoenix, Arizona, USA
                                                    Rochester, Minnesota, USA
Jens Otto Lunde Jørgensen, MD, DMSci                                                              Megan R. Haymart, MD
Aarhus University Hospital                                                                        University of Michigan
                                                    Nienke Biermasz, MD, PhD
Aarhus, Denmark                                     Leiden University Medical Center              Ann Arbor, Michigan, USA
                                                    Leiden, The Netherlands
Sangeeta R. Kashyap MD
Cleveland Clinic Foundation
Cleveland, Ohio, USA

J Clin Endocrinol Metab, February 2021, 106(2):7A                                                               https://academic.oup.com/jcem       7A
JCEM
                                   THE JOURNAL
                                                                                                                                             February 2021
                                   OF CLINICAL
                                   ENDOCRINOLOGY                                EDITORIAL BOARD                                               VOLUME 106
                                   & METABOLISM                                continued from EB 4A                                             NUMBER 2

Reiko Horikawa, MD, PhD                             Mitsuhide Naruse, MD, PhD                            William F. Simonds, MD
National Center for Child Health and Development    Ijinkai Takeda General Hospital                      National Institutes of Health / NIDDK
Tokyo, Japan                                        NHO Kyoto Medical Center                             Bethesda, Maryland, USA
                                                    Kyoto, Japan
Gregory A. Kaltsas, MD, PhD, FRCP                                                                        Noel P. Somasundarum, MD
National and Kapodistrian University of Athens      Karel Pacak, MD, PhD, DSc, FACE                      National Hospital of Sri Lanka
Athens, Greece                                      National Institutes of Health / NICHD                Colombo, Sri Lanka
                                                    Bethesda, Maryland, USA
Kok Onn Lee, MBBS, MD, FRCP(Edin)                                                                        Kathryn C.B. Tan, MD
National University of Singapore                    Stephanie Page, MD, PhD                              University of Hong Kong
Singapore                                           University of Washington School of Medicine          Hong Kong
                                                    Seattle, Washington, USA
Ana Luiza Maia, MD, PhD                                                                                  Elena Tsourdi, MD
Universidade Federal do Rio Grande do Sul           Nelly Pitteloud, MD                                  Dresden University Medical Center
Porto Alegre, Brazil                                Centre Hospitalier Universitaire Vaudois             Dresden, Germany
                                                    Lausanne, Switzerland

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Monica Marazuela, MD, PhD                                                                                Anand Vaidya, MD, MMSc
Hospital de la Princesa, Universidad Autonoma       Catalina Poiana, MD, PhD, FACE                       Brigham and Women’s Hospital
de Madrid                                           “Carol Davila” University of Medicine and Pharmacy   Boston, Massachusetts, USA
Madrid, Spain                                       Bucharest, Romania
                                                                                                         Jacques Young, MD, PhD
Erica E. Marsh, MD, MSCI, FACOG                     Michael Rosenbaum, MD                                University Paris Saclay, INSERM and AP-HP
University of Michigan                              Columbia University Irving Medical Center            Le Kremlin-Bicêtre, France
Ann Arbor, Michigan, USA                            New York, New York, USA
                                                                                                         Hongting Zheng, MD
Philippa Melamed, PhD                               Sebastian M. Schmid, MD                              The Second Affiliated Hospital of Army Medical
Technion - Israel Institute of Technology           Universität zu Lübeck                                University
Haifa, Israel                                       Lübeck, Germany                                      Chongqing, China

Zaher Merhi, MD, HCLD                               Claudia E. Sedlinsky, MD                             Zhiguang Zhou, MD, PhD
Einstein & New York University School of Medicine   Instituto Cesar Milstein                             Second Xiangya Hospital of CSU
New York, New York, USA                             Buenos Aires, Argentina                              Changsha, Hunan, China

Veronica Mericq, MD                                 Nalini S. Shah, MD
University of Chile                                 King Edward Memorial Hospital                        ENDOCRINE SOCIETY STAFF
Santiago, Chile                                     Mumbai, India
                                                                                                         Richard T. O’Grady, PhD
V. Mohan, MD, PhD, DSc, FRCP, FACE                  Susmeeta T. Sharma, MD, MHSc                         Publisher
Dr. Mohan’s Diabetes Specialities Centre            Medstar Washington Hospital Center/Georgetown
                                                    University Hospital                                  Timothy M. Beardsley, DPhil
Chennai, India
                                                    Washington, DC, USA                                  Executive Editor
Giovanna Muscogiuri, MD
University of Naples Federico II                    Young Kee Shong, MD, PhD
Naples, Italy                                       Asan Medical Center
                                                    Seoul, South Korea

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