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Spring/Summer 2020 | Volume 10, No. 1 HOME >
News from the Roberta and Stephen R. Weiner Department of Surgery
at Beth Israel Deaconess Medical Center
INSIDE SURGERY
EARLY PROSTATE CANCER:
To Treat or Not to Treat?
PASS Trial
Seeks Answers
page 17
>
IN THIS ISSUE
3 HMS Promotions 10 Colon and Rectal Surgery
4
New Faculty 13 Upcoming Events
5 Neuromodulation for 14
Selected Publications
Facial Pain
17 PASS Trial
6 Alumni Spotlight:
Yue-Yung Hu, MD, MPH 18 News Briefs Spring/Summer 2020
Volume 10, No. 1
8
Hispanic Breast Cancer
Program
Inside Surgery is published by the
Office of the Chairman of the
Roberta and Stephen R. Weiner
Message from the Chair Department of Surgery at Beth Israel
Deaconess Medical Center for
A s I write this message, we are in the throes of dealing faculty, trainees, staff, alumni,
with the coronavirus pandemic. Each day presents a affiliates, and friends.
new set of challenges, from obtaining adequate personal
protective equipment or arranging for sufficient critical- The mission of the
Department of Surgery:
care beds for the anticipated influx of COVID-19 patients
• Provide care of the very
to maximizing the use of telemedicine technology so that
highest quality
we can continue to take care of all patients and sustain our
• Improve health through
teaching mission during these extraordinary times. innovation and discovery
Yet despite the uncertainty, long days, and concerns about their own • Prepare future leaders in
and their loved ones’ well-being, the members of the Department of American surgery
Surgery have risen to these and countless other challenges with courage, • Serve our communities with
determination, ingenuity, and resolve. sensitivity and compassion
I witnessed this same spirit during the Boston Marathon bombings,
when we were also challenged in unanticipated ways. Now, as then, the Surgery Chair
Elliot Chaikof, MD, PhD
women and men in the Department of Surgery have never wavered, putting
aside their own needs to save lives, reduce suffering, and rapidly find Editor/Writer
innovative solutions to unprecedented problems. Hilary Bennett
Unwavering perseverance in the face of daunting circumstances is Photography
nothing new in our department. Consider these words by the illustrious Danielle Duffey/BIDMC
surgeon Dr. David Williams Cheever (1831-1915), who led the Fifth (Harvard) James Dwyer/BIDMC
Surgical Service—the predecessor of our General Surgery Residency
Please forward comments, news
Program—during the Civil War.
items, and requests to be added to
“...We struggled bravely to fight sepsis amid the terrible or removed from the mailing list to:
Editor, Inside Surgery, Beth Israel
discouragement of those surgical days so full of mortality. Amputation,
Deaconess Medical Center,
when primary, often gave a mortality of 50 percent. In abdominal Department of Surgery, LMOB-9C,
operations, more died than recovered. Much debility and poor blood 110 Francis St., Boston, MA 02215.
were brought to our hospital by the returning Union Army; chronic E-mail: surgerycommunications@
diarrhea, malaria, old suppurating wounds. This influence lasted for bidmc.harvard.edu
years. But we never wavered in our daily visits and honest efforts…”
Tel: 617-632-9581
By the time you receive this issue of Inside Surgery, the current situation
bidmc.org/surgery
will certainly have changed—if we are fortunate, for the better—so that even
as we will mourn for lives lost to this scourge we can begin to return to our
PLEASE NOTE: All group photos in
normal lives. Until then, like those who came before us, we will never waver this issue were taken prior to the
in our efforts to fulfill our mission to provide care of the very highest quality social-distancing policies put in place
and improve health through innovation and discovery. due to the coronavirus pandemic.
Follow us on Twitter
@BIDMCSurgery
Elliot Chaikof, MD, PhD
#NeverWaver
bidmc.org/surgery Inside Surgery | Spring 2020 — Page 2
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PROMOTED TO: ASSOCIATE PROFESSOR OF SURGERY
Dhruv Singhal, MD Considered one of the world’s leading experts in
Dr. Singhal, a member of the lymphedema prevention and treatment, Dr. Singhal is
Division of Plastic and Reconstructive frequently invited to present his work at major conferences
Surgery, is the founder and Director nationally and internationally.
of the BIDMC Lymphatic Center, the Dr. Singhal’s research, which is supported by multiple
only comprehensive referral center grants, involves refining his group’s animal model to
for lymphedema in New England. further investigate the physiology of surgical lymphedema
He joined the Department of prevention at the time of axillary node dissection. In
Surgery in 2016. addition, he maintains a tissue bank and a large patient
A graduate of the University database for research aimed at improving the care of
of Pittsburgh School of Medicine, Dr. Singhal completed patients with lymphedema.
his general surgery residency at Brigham and Women’s An enthusiastic teacher of trainees at all levels,
Hospital and his plastic surgery residency in the combined Dr. Singhal also serves as the Chair of the Program
Harvard Plastic Surgery Program. He completed a Committee for the Lymphatic Symposium hosted by
fellowship in craniofacial surgery at Chang Gung the BIDMC Lymphatic Center, an annual educational
Memorial Hospital and a fellowship in microsurgery at event he launched in 2017 that attracts hundreds of
China Medical University Hospital, both in Taiwan. Prior health care professionals and patients from around
to joining BIDMC, Dr. Singhal practiced at UF Health the world (see page 13 for information about the next
Shands Hospital in Gainesville, Florida, and was Director symposium in early 2021).
of Microsurgery and Director of Adult Craniofacial Surgery Dr. Singhal is an ad hoc reviewer for Plastic and
at the University of Florida School of Medicine. Reconstructive Surgery, PRS Global Open, Annals
Dr. Singhal is a pioneer in preventive lymphovenous of Plastic Surgery, and Journal of Reconstructive
bypass surgery at the time of axillary node dissection Microsurgery, and serves on the editorial board of the
for breast cancer patients at high risk of lymphedema. International Microsurgery Journal. He has had more
He also performs vascularized lymph node transfer for than 70 papers published, including more than 60 in
the treatment of patients with chronic lymphedema. peer-reviewed journals.
PROMOTED TO: ASSISTANT PROFESSOR OF SURGERY
David Liu, MD
Dr. Liu is a staff physician in the Sloan Kettering Cancer Center in New York City.
Division of Cardiac Surgery, Following his residency, Dr. Liu completed a fellowship
Surgical Director of the BIDMC in cardiothoracic surgery at Tufts Medical Center.
Heart Failure Service, and A Fellow of the American College of Surgeons,
Associate Program Director of the Dr. Liu’s clinical interests are minimally invasive cardiac
Cardiothoracic Surgery Fellowship. surgery, coronary artery bypass surgery, valve repair
Dr. Liu was a clinical associate in and replacement, complex aortic surgery, ventricular
the Division of Cardiac Surgery at assist devices, heart failure, and transcatheter valves.
BIDMC from 2006 to 2007, and In collaboration with BIDMC colleagues from
following two years as an attending cardiac surgeon at Anesthesia, Cardiology, and Vascular Surgery, Dr. Liu
Saint Vincent Hospital in Worcester, Mass., was recruited is involved in several national clinical trials, most of
back to the BIDMC Department of Surgery in 2009. which pertain to the treatment of valvular disorders
Dr. Liu earned his medical degree from Tufts via percutaneous routes.
University School of Medicine and completed his Dr. Liu is a committed teacher and mentor to
residency in general surgery at the Medical College of trainees at all levels. In 2017, he was selected by
Ohio. During his residency, he completed a two-year BIDMC’s General Surgery residents to receive the
research fellowship in thoracic surgery at Memorial John L. Rowbotham Award for Excellence in Teaching.
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New Faculty
For more information about our new faculty, including their clinical and research interests,
please visit the “Find-A-Doctor” section on the BIDMC website.
Ryan Cauley, MD, MPH Fayez Kheir, MD, MSc
Division: Plastic and Division: Thoracic Surgery and
Reconstructive Surgery Interventional Pulmonology
Medical School: Weill Cornell Medical School: University of
Medicine Balamand, Lebanon
MPH: Harvard T. H. Chan School Residency: Internal Medicine,
of Public Health Rosalind Franklin University of
Residency: General Surgery, Medicine and Science
Brigham and Women’s Hospital; Clinical Fellowships: Pulmonary
Plastic Surgery, Harvard and Critical Care Medicine, Tulane
Combined Plastic Surgery University; Interventional
Residency Program Pulmonology, Beth Israel
Clinical Fellowships: Acute Burn Deaconess Medical Center/
Surgery and Reconstruction, Massachusetts General Hospital
Massachusetts General Hospital; Phone: 617-632-8252
Surgical Critical Care, Brigham
and Women’s Hospital;
Microsurgery, Beth Israel Heidi J. Rayala, MD, PhD
Deaconess Medical Center Division: Urologic Surgery
Phone: 617-632-7827 Medical School/PhD: Washington
University School of Medicine
Salima Hassanaly, MD Residency: Urology, Harvard
Program in Urology
Division: Ophthalmology
(Longwood Area)
Medical School: University
Clinical Fellowship: Urologic
of Montreal
Oncology, Memorial Sloan
Residency: Ophthalmology, Kettering Cancer Center
University of Montreal
Phone: 617-667-3739
Clinical Fellowships: Cornea and
External Diseases, Illinois Eye and
Ear Infirmary; Refractive Cornea Lars Stangenberg, MD, PhD
and Cataract Surgery, Boston
Division: Vascular and
Laser/Boston Eye Group
Endovascular Surgery
Phone: 617-667-3391
Medical School/PhD: Albert
Ludwig University of Freiburg,
Germany
Residency: General Surgery,
Massachusetts General Hospital
Clinical Fellowship: Vascular and
Endovascular Surgery, Beth Israel
Deaconess Medical Center
Phone: 617-632-9959
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Facing Intractable Facial Pain
Neuromodulation Can Provide Much-Needed Relief
Neurosurgeon Jeffrey Arle, MD, PhD (left), is one of the world's leading experts in neuromodulation.
F or nearly 30 years,
Carol Mannila, a former
registered nurse from central
radiosurgery. Characterized by
persistent, severe, burning or
aching pain, rather than brief
Jeffrey Arle, MD, PhD, one of
the world’s leading experts in
neuromodulation.
Massachusetts, suffered from episodes of pain, this type of TN
unrelenting, stabbing pain behind often gets worse with time. Blocking pain signals
her left eye. “The pain was 24/7 Like many other TN sufferers, Dr. Arle is one of a small number
and excruciating,” she says. Ms. Mannila was in nearly of surgeons in the nation to offer
Ms. Mannila was suffering constant pain, went to dozens neuromodulation for patients
from a type of trigeminal of doctors over the years, and with intractable conditions that
neuralgia (TN), an often- tried virtually every available cause chronic, severe facial pain.
disabling condition that can be treatment, none of which For years, neuromodulation has
caused by trauma, surgery, or provided significant, lasting relief. been used to treat severe back,
infection. The condition is often The pain become so intense she leg, neck, and arm pain. In the
misdiagnosed and may be had to quit her job. Her longtime case of facial pain, the treatment
difficult to treat with conventional specialist, unable to provide entails electrically stimulating
methods, which include any further options, referred the peripheral branches of the
medications, nerve blocks, and her to BIDMC neurosurgeon
Continued on page 28 >
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ALUMNI SPOTLIGHT
Yue-Yung Hu, MD, MPH, 2015
Pediatric Surgeon, Ann & Robert H. Lurie
Children’s Hospital of Chicago
Assistant Professor of Surgery, Northwestern
University Feinberg School of Medicine
G rowing up, Yue-Yung Hu assumed she would
follow in the footsteps of her parents, PhDs
in immunology and analytical chemistry. But after
working in wet labs during high school, college, and
later, she realized bench research was not for her.
She discovered public health—which merged
science with another of her interests, service—and
began working with a primary-care pediatrician on
post-9/11 mental health issues. Inspired, she decided
to become a pediatrician and attended SUNY Stony
Brook School of Medicine. But during her clinical
rotations, Dr. Hu discovered a new passion: surgery.
During her residency in BIDMC’s General
Surgery Residency Program, Dr. Hu earned a is also Associate Director of the General Surgery
master’s degree in clinical effectiveness from the Residency Program.
Harvard T. H. Chan School of Public Health and
spent three years as a research fellow at Brigham FIRST trial
and Women’s Hospital with Caprice Greenberg, When Dr. Hu joined Northwestern, the FIRST
MD, MPH. She was referred to Dr. Greenberg by her (Flexibility In duty-hour Requirements for Surgical
advisor Sidhu Gangadharan, MD, MHCM, Chief of Trainees) trial, which changed residents’ duty-hour
Thoracic Surgery and Interventional Pulmonology. policy, was concluding. What the follow-up data
“Dr. Gangadharan’s suggestion impacted my revealed was alarming: 39% of U.S. general surgery
career,” says Dr. Hu, adding that “the BIDMC residents experience symptoms of burnout weekly,
residency offered a very supportive environment, and many aspects of the learning environment—not
which I still draw on today.” just duty hours—contribute to poor well-being. More
In Dr. Greenberg’s lab, Dr. Hu used than 7,400 residents, or 99.3% of those surveyed,
intraoperative video to study quality and safety. from all ACGME-accredited residency programs
“Dr. Greenberg was an inspiring mentor who across the U.S. had participated in the study.
supported me to have my own research interests,” Dr. Hu was co-first author of a paper published
she says. When Dr. Hu returned to her clinical in October 2019 in the New England Journal of
residency, she was drawn to pediatric surgery. Medicine (N Eng J Med 381;18), demonstrating that
“It took me a few wrong turns to find my calling, mistreatment (discrimination, verbal or physical
but I eventually got it right,” she says. abuse, and sexual harassment) occurs frequently
After completing her pediatric surgery among general surgery residents, especially
fellowship at Connecticut Children’s in 2017, Dr. Hu women, and is associated with burnout and
was recruited to the Ann & Robert H. Lurie Children’s suicidal thoughts (see graphic). After controlling for
Hospital of Chicago, where she provides general this mistreatment, the previously reported gender
pediatric surgical care and conducts health services disparities in these wellness outcomes became
research with a focus on surgical education. She insignificant, notes Dr. Hu.
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SECOND trial of programmatic ideas and initiatives, as well as
As the FIRST trial results made clear, more must implementation support. After the conclusion of the
done to improve residents’ well-being. To help study, programs in the control arm will have access
achieve that goal, the SECOND (Surgical Education to all available resources.
Culture Optimization through targeted interventions “Residency programs need data about
based on National comparative Data) trial was their performance so they can focus their efforts
launched, with Dr. Hu and Karl Bilimoria, MD, MS, to improve trainees’ well-being,” says Dr. Hu,
also of Northwestern University, as co-principal emphasizing that some programs have very low
investigators. rates of mistreatment. “They also need access to
In the SECOND trial, participating residency readily available strategies to make improvements
programs are randomized to a control arm vs. so no one has to reinvent the wheel.”
an intervention arm. All programs are given a Under the leadership of Dr. Hu and her
confidential report of their residents’ well-being colleagues in the SECOND trial, those needs will be
data compared to other programs in the U.S., as addressed and steps taken to ensure that all surgery
well as suicidality interventions. Programs in the residents are training in an environment that fosters
intervention arm (which includes BIDMC’s) receive their well-being so they can learn, thrive, and reach
access to a Wellness Toolkit that offers a wealth their full potential.
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Hispanic Breast Cancer Program
Meeting the Unique Needs of Hispanic Patients
R eceiving a diagnosis of
breast cancer is difficult for
any woman. But if a language
barrier makes it impossible for
a patient to fully understand her
diagnosis, treatment options, and
next steps, the news is all the more
upsetting. Further, it can contribute
to a poor outcome. Unfortunately
this is all-too-frequently the
predicament of Hispanic women,
particularly those who are not
native English speakers.
In addition to a language
barrier, it is well-documented
that other socioeconomic and
cultural factors—so-called
social determinants of care—
can compromise the care and
outcomes of minorities, including
Hispanic women. Indeed, multiple
studies show that Hispanic women
with breast cancer are more
likely to be diagnosed at a more
advanced stage and, consequently,
more likely to die from their disease Monica Valero, MD (seated), shown here with Susan McCauley, RN, launched the new
than non-Hispanic women of the Hispanic Breast Cancer Program.
same age and stage of cancer.
Culturally appropriate in surgical critical care at Brigham uncomfortable or shy to ask for
Through the creation of BIDMC’s and Women’s Hospital/Dana- an interpreter. “I felt that with my
Hispanic Breast Cancer Program Farber Cancer Institute and a background and interests I should
Monica G. Valero, MD, is determined clinical fellowship in breast surgical be the one to lead a program that
to change this. Dr. Valero launched oncology at Memorial Sloan will provide Hispanic women with
the program in October 2019, Kettering Cancer Center. an inclusive, culturally appropriate
shortly after she joined the Division Her years in Boston taught environment and take steps to
of Surgical Oncology in the Dr. Valero that while the region has begin to address health disparities
Department of Surgery. an abundance of highly qualified in this population,” says Dr. Valero.
A native of Venezuela, breast surgeons, the unique needs The program received
Dr. Valero attended medical of Hispanic women were not wholehearted support from Ted
school in Caracas with the goal of being adequately met. She recalls James, MD, MS, Chief of Breast
becoming a breast surgeon. She numerous instances during her Surgical Oncology. “No one is more
came to the United States 10 years training where she had to step in qualified to lead this program or
ago for her postgraduate training, to explain in Spanish about the more committed to serving the
which included a residency in nuances of treatment to Hispanic needs of Hispanic women than
general surgery and a fellowship patients, who were either too Dr. Valero,” says Dr. James. “The
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entire multidisciplinary BreastCare only treatment-related matters impact of delays in the advent of
Center team is excited to be part but also issues that might affect adjuvant chemotherapy among
of this program, which is designed their ability to receive care, such Hispanic patients.
to address the inequities in breast as transportation, access to social
care for these patients.” Dr. James workers, and help managing issues Education and
points out that the BreastCare at home or work. The program community outreach
Center already cares for a currently has three patient Many Hispanic women are
significant number of Hispanic navigators and plans to hire a diagnosed with breast cancer at
patients, but welcomes and expects fourth who speaks fluent Spanish. later stages, when treatment may
more to seek care at BIDMC as a be less effective, largely because
result of this program. Research to reduce disparities they are not being screened
The Hispanic Breast Cancer Another priority of the Hispanic for the disease. “We need to
Program aims to fulfill its mission Breast Cancer Program is to educate Hispanic women about
in multiple ways: through tailored conduct research aimed, in part, the importance of screening
clinical services, research, at identifying disparities in care, mammography,” says Dr. Valero.
education, and community finding and evaluating ways to To accomplish this, the program
outreach. In addition to Dr. Valero reduce or eliminate them, and will offer educational events about
and fellow breast surgeons Mary disseminating findings to clinicians prevention and early detection
Jane Houlihan, MD, Betty Fan, and researchers. during Breast Cancer Awareness
DO, Alessandra Mele, MD, and Critical to this effort is Month. In addition, the program
Dr. James, the program includes increasing Hispanic patients’ will establish ongoing breast
dedicated interpreters, nurses participation in clinical trials, a cancer survivor support groups.
and nurse practitioners, social high priority among the program’s Over the coming year, Dr. Valero
workers, patient navigators, team. Another priority is to build and other members of the team
and administrative staff. All
are committed to providing an
inclusive, culturally appropriate “Reducing health disparities among Hispanic women and
environment for Hispanic patients
other minorities is an enormous undertaking that requires
and addressing their specific
needs. Several, including Dr. Valero many resources. With our new program, we are taking
and her administrative assistant, meaningful steps toward that important goal.”
speak fluent Spanish. — Monica Valero, MD
Patient navigators an important research tool: will visit BIDMC sites to share
Patient navigators are an essential a database that will include information about the program
component of the program, says information specific to Hispanic and educate women in their local
Dr. Valero. “Breast cancer treatment patients. Another future research communities.
today involves multidisciplinary project will assess the costs and “Reducing health disparities
treatment—surgery, radiation benefits of cancer screening and among Hispanic women and
therapy, and chemotherapy or patient navigation services for other minorities is an enormous
hormone therapy. Our patient Hispanic Medicare recipients. undertaking that requires many
navigators help guide patients The program’s research is resources,” says Dr. Valero. “With
through the system to ensure that already gaining widespread interest our new program, we are taking
they receive the care they need among the medical community. For meaningful steps toward that
at the appropriate times.” example, Dr. Valero was selected to important goal.”
Patient navigators, all of present at the upcoming Society of
whom are registered nurses, are Surgical Oncology annual meeting ➔ To schedule an appointment
the patient’s go-to person for on her and her team’s research, or make a referral, call:
which identified and described the
617-667-2900
any and all needs, including not
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Colon and Rectal Surgery
Working Together to Improve Lives
Evangelos Messaris, MD, PhD, Chief of the Division of Colon and Rectal Surgery (right), leads a team that includes three
fellowship-trained colon and rectal surgeons with a fourth to join the group later this year.
P atients newly diagnosed with
colorectal cancer have enough
to deal with without worrying about
Cancer patients who are
treated in the BIDMC Division of
Colon and Rectal Surgery can cross
specializing in colorectal cancer,
meets in a weekly Tumor Board to
develop each patient’s treatment
how long it will take to get timely those concerns off their list. plan. Within 48 hours of being
appointments with the specialists They are given an appointment seen, the patient receives a written
who will treat their disease—which within seven days and meet with care plan and the services of an
invariably includes a colorectal their entire multidisciplinary team experienced patient navigator,
surgeon, a medical oncologist, of specialists in the same room. Jeanne Quinn, NP, who helps
and a radiation oncologist—and Following the completion of facilitate treatments, answers
wondering whether everyone necessary tests, everyone involved questions, and serves as a go-
involved is communicating with in the patient’s care, including to person for any and all issues
one another. a pathologist and radiologist relating to the patient’s care.
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This efficient and effective state-of-the-art surgical and these numbers are expected
approach to patient care is treatments, for patients with to increase. To meet the growing
no accident. When Evangelos virtually all conditions affecting demand for its services, the division
Messaris, MD, PhD, Chief of the the colon and rectum: has recruited another fellowship-
Division of Colon and Rectal •
Cancer: colon cancer, trained colorectal surgeon, Kristen
Surgery, joined BIDMC in 2018, rectal cancer Crowell, MD, who is completing her
improving access was one of his •
Inflammatory Bowel Disease: training at Cleveland Clinic in Ohio
highest priorities. “All members of Crohn’s disease, ulcerative colitis, and will join BIDMC later this year.
our team share a common goal—to indeterminant colitis
provide the best possible care for • B enign Diseases: fecal Latest surgical options
each of our patients—and rapid incontinence, pelvic floor One of the division’s major
access is an important part of disorders, diverticulitis, anorectal strengths is its Rectal Cancer
that,” he says. Patients with acute diseases (fistulas, anal fissures, Program, which in addition to
conditions are seen within 24 hours hemorrhoids), rectal prolapse, comprehensive, well-coordinated
and those with benign conditions polyps of the colon and rectum. care, offers the latest surgical
options. For patients with distal
rectal cancer, this includes
transanal total mesorectal excision
“All members of our team share a common goal— (TaTME), an advanced procedure
to provide the best possible care for each of our offered at only a few medical
patients—and the rapid access we offer is an centers in the region. Performed
important part of that.” via the anus, TaTME offers the
ability to remove a distal rectal
— Evangelos Messaris, MD, PhD
cancer with appropriate margins
and reduces the chance that the
within 15 days—times that will Approximately 80 percent patient will require a permanent
likely decrease still further with of patients, who come from ostomy. Patients with cancer or
the addition of colorectal surgeon throughout New England, are who require surgery for IBD or
Anne Fabrizio, MD, who joined the treated for cancer or inflammatory diverticulitis may be candidates
group in October 2019. bowel disease. In part due for single-port laparoscopic
In addition to three fellowship- to its reputation for providing surgery, which requires only a
trained colorectal surgeons, the high-quality care (BIDMC was single small incision in the navel
division includes five advanced designated as “high performing”— and is virtually scarless.
practice providers, including two the highest possible ranking—in The division puts a high
outpatient nurse practitioners colon cancer surgery by U.S. News priority on maintaining the highest
(Kristin Messer, NP, and Jeanne & World Report in 2019), the division quality of care to ensure the best
Quinn, NP), two inpatient nurse is experiencing rapid growth. possible outcomes. One example
practitioners (Heather Pleskow, Last year, Dr. Messaris and his of this commitment to quality is the
NP, and Julie Rocke, NP), and colleagues performed more than division’s Enhanced Recovery after
certified ostomy care nurse 500 major colorectal resections Surgery Pathway, which provides
Daniel Lonergan, RN. The group’s and recorded more than 1,200 evidence-based guidelines for
administrative leaders are Kristen visits to the division’s two clinical post-operative care on everything
Skiles and Rozlyn Edwards (See sites in Boston (the BIDMC main from diet and pain management
"Our Team," page 13). campus and Harvard Vanguard to IV fluids.
The division provides Medical Associates/Kenmore), “As a result of this pathway
comprehensive care, including BID-Milton, and BID-Needham— based on billing data, we have
Continued on page 12 >
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< Continued from page 11
the shortest length of stay for with BIDMC gastroenterology recently received a $100,000
colorectal resections of any large (GI) faculty, who also expose grant from the Crohn’s and Colitis
hospital in Massachusetts,” says the trainees to GI motility and Foundation to support research
Dr. Messaris. He emphasizes that pelvic floor evaluation as well aimed at predicting IBD patients’
this would not be possible without as interventional GI procedures. response to medications that could
the pre-operative education Fellows also participate in research lead to early surgery. The division’s
provided by Mr. Lonergan and projects and develop and complete research is presented nationally
the BIDMC ostomy nurses; the a quality-improvement project. and internationally and published
perioperative care provided by the Faculty also train Harvard widely in top journals, including
Stoneman-5 team led by Nursing Medical School (HMS) clerkship the highest ranked journal in the
Director for Inpatient Surgery Scott students, participate in the sub- specialty, Diseases of the Colon
Rollins, MSN, RN; and the division’s internship program, and teach and Rectum, which includes
inpatient nurse practitioners, and train BIDMC General Surgery Dr. Messaris on its editorial board.
Ms. Pleskow and Ms. Rocke. residents through didactics,
bedside and OR teaching, and the Giving back
Teaching and training HMS Surgical Anatomy Program. In addition to caring for patients,
In 2018, the division launched a members of the division are
one-year ACGME-accredited Colon Research committed to helping those outside
and Rectal Surgery Fellowship Another priority of the division the medical center. Last year they
Program, led by Program Director is research, and all faculty are participated in the Colon Cancer
Thomas Cataldo, MD, with external engaged in outcomes research. Coalition’s “Get Your Rear in Gear”
collaborators Mandeep Saund, MD, One area of focus is the fundraising 5K walk, raising more
of Atrius Health, and Dana Fugelso, development of clinical pathways than $1,600 for the organization—
and plan to do so again this year.
In addition, via Camp Harbor
View, the entire division “adopts” a
One of the division’s major strengths is its Rectal family in need for a year, donating
Cancer Program, which in addition to comprehensive, essential items as well as non-
well-coordinated care, offers the latest surgical essential but important gifts that
brighten their lives. Ms. Edwards
options, including transanal total mesorectal excision
and Ms. Messer also proudly serve
for patients with distal rectal cancer. in the U.S. Air Force and will be
deployed for much of 2020.
Dr. Messaris is justifiably
proud of his team and their shared
MD, MPH, in private practice. The and other systems initiatives for accomplishments, attributing the
first trainee, Kristina Go, MD, will optimal patient care using data division’s growth and excellent
graduate this August. The second from the division and the National reputation to teamwork and
fellow is Jeremy Dressler, MD, from Surgical Quality Improvement common goals. “We work together
Brown University. Program (NSQIP). The focus of to provide the highest quality
Fellows participate in all other ongoing projects includes care to our patients, train the next
aspects of colon and rectal surgery outcomes in rescue therapy for generation of colorectal surgeons,
practice, including outpatient ulcerative colitis and the impact conduct research that will help
clinics, the Rectal Cancer Clinic, of ethnicity on patient outcomes, improve our understanding and
inpatient and outpatient surgeries, to cite just a few. treatments of colorectal conditions,
endoscopy, and inpatient patient The division also participates and strive to help others in the
care. In addition, fellows perform in several multi-center, national broader community of which we
colonoscopies in collaboration clinical trials, and Dr. Messaris are a part,” he says.
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UPCOMING EVENTS
GlycoT 2020:
Our Team 12th International Symposium
on Glycosyltransferases
Surgeons
This year’s symposium will be hosted
virtually on June 21-23.
Organizers and Chairs:
Richard D. Cummings, PhD, BIDMC;
Michael Pierce, PhD, University
of Georgia
To register/for more information:
glycot2020.com
4th Annual
Evangelos Messaris, MD, PhD Thomas E. Cataldo, MD Lymphatic Symposium
Chief (Clinical Symposium)
This year’s symposium, originally
scheduled for November 13-14, was
postponed to early 2021. When
available, new dates will be posted
at: harvardlymphaticsurgery.org.
Hosted by the Lymphatic Center at
BIDMC (Director, Dhruv Singhal, MD),
in partnership with the Lymphatic
Education and Research Network
To register/for more information:
harvardlymphaticsurgery.org
Anne C. Fabrizio, MD
4th Annual
Lymphatic Symposium
Advanced Administrative (Patient Symposium)
Practice Providers Leadership This year’s symposium, originally
scheduled for November 14, was
Daniel Lonergan, RN Kristen Skiles
Administrative Director postponed to early 2021. When
Kristin Messer, NP available, new dates will be posted
Rozlyn Edwards at: harvardlymphaticsurgery.org.
Heather Pleskow, NP
Administrative Supervisor
Jeanne Quinn, NP Hosted by the Lymphatic Center at
BIDMC (Director, Dhruv Singhal, MD),
Julie Rocke, NP in partnership with the Lymphatic
Education and Research Network
To register/for more information:
harvardlymphaticsurgery.org
➔ To schedule an appointment or make a referral, PLEASE NOTE: All dates in this issue
call: 617-667-4159 are subject to change based on the
status of the coronavirus pandemic.
bidmc.
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org/
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Selected Publications
Acute Care Surgery, Trauma, Baribeau Y, Sharkey A, Mahmood E, Matsumoto Y, Kudelka MR, Hanes MS,
Feng R, Chaudhary O, Baribeau V, Lehoux S, Dutta S, Jones MB, Stackhouse
and Surgical Critical Care Mahmood F, Matyal R, Khabbaz K. KA, Cervoni GE, Heimburg-Molinaro J,
Itagaki K, Kaczmarek E, Kwon WY, Chen Three-dimensional printing and Smith DF, Ju T, Chaikof EL, Cummings
L, Vlková B, Zhang Q, Riça I, Yaffe MB, transesophageal echocardiographic RD. Identification of Tn antigen
Campbell Y, Marusich MF, Wang JM, imaging of patient-specific mitral valve O-GalNAc-expressing glycoproteins in
Gong WH, Gao JL, Jung F, Douglas G, models in a pulsatile phantom model. human carcinomas using novel anti-Tn
Otterbein LE, Hauser CJ. Formyl peptide J Cardiothorac Vasc Anesth 2019; recombinant antibodies. Glycobiology
receptor-1 blockade prevents receptor 33(12): 3469-75. 2019; in press.
regulation by mitochondrial danger-
associated molecular patterns and Colon and Rectal Surgery McQuillan AM, Byrd-Leotis L, Heimburg-
preserves neutrophil function after Molinaro J, Cummings RD. Natural and
trauma. Crit Care Med 2019; in press. Wong DJ, Curran T, Poylin VY, Cataldo synthetic sialylated glycan microarrays
TE. Surgeon-delivered laparoscopic and their applications. Front Mol Biosci
Kondo Y, Ledderose C, Slubowski CJ, transversus abdominis plane blocks are 2019;13;6:88.
Fakhari M, Sumi Y, Sueyoshi K, Bezler AK, non-inferior to anesthesia-delivered
Aytan D, Arbab M, Junger WG. Frontline ultrasound-guided transversus Mehta AY, Cummings RD. GLAD: GLycan
Science: Escherichia coli use LPS as abdominis plane blocks: A blinded, Array Dashboard, a visual analytics tool
decoy to impair neutrophil chemotaxis randomized non-inferiority trial. Surg for glycan microarrays. Bioinformatics
and defeat antimicrobial host defense. J Endosc 2019; in press. 2019;15;35(18):3536-37.
Leukoc Biol 2019; in press.
General Surgery Wei M, McKitrick TR, Mehta AY, Gao C,
Kondo Y, Sueyoshi K, Zhang J, Bao Y, Li X, Jia N, McQuillan AM, Heimburg-
Kent TS, Watkins AA, Castillo-Angeles M. Molinaro J, Sun L, Cummings RD. Novel
Fakhari M, Slubowski CJ, Bahrami S,
Response to letter to the editor about the reversible fluorescent glycan linker for
Ledderose C, Junger WG. Adenosine
recently published paper by Watkins et functional glycomics. Bioconjug Chem
5’-monophosphate protects from
al. Braden scale for pressure ulcer risk 2019;30(11):2897-2908.
hypoxia by lowering mitochondrial
predicts rehabilitation placement after
metabolism and oxygen demand. Shock
pancreatic resection. HPB (Oxford) Neurosurgery
2019; in press.
2019;21(7):929.
Arle JE, Mei L, Carlson KW. Fiber
Otterbein LE. Conquering radicals with
Watkins AA, Castillo-Angeles M, threshold accommodation as a
a sense of humor. Cell Chem Biol
Calvillo-Ortiz R, Guetter CR, Eskander mechanism of burst and high-frequency
2019;26(10):1335-37.
MF, Ghaffarpasand E, Anguiano-Landa spinal cord stimulation.
Patterson JC, Joughin BA, Prota AE, L, Tseng JF, Moser AJ, Callery MP, Kent Neuromodulation 2019; in press.
Mühlethaler T, Jonas OH, Whitman MA, TS. Braden scale for pressure ulcer risk
Varmeh S, Chen S, Balk SP, Steinmetz predicts rehabilitation placement after Atesok K, Vaccaro A, Stippler M, Striano
pancreatic resection. HPB (Oxford) BM, Carr M, Heffernan M, Theiss S,
MO, Lauffenburger DA, Yaffe MB.
VISAGE reveals a targetable mitotic 2019;21(7):923-7. Papavassiliou E. Fate of hardware in
spindle vulnerability in cancer cells. Cell spinal infections. Surg Infect (Larchmt)
Zhao Z, Shi A, Wang Q, Zhou J. High oleic 2019; in press.
Syst 2019;9(1):74-92.
acid peanut oil and extra virgin olive oil
Yuan W, Cook CH, Brat GA. Addressing supplementation attenuate metabolic Foreman PM, Salem MM, Griessenauer
limitations in case-control study of syndrome in rats by modulating the gut CJ, Dmytriw AA, Parra-Farinas C,
patients undergoing resuscitative microbiota. Nutrients 2019;11:3005. Nicholson P, Limbucci N, Kühn AL, Puri
endovascular balloon occlusion of the AS, Renieri L, Nappini S, Kicielinski KP,
aorta. JAMA Surg 2019; in press. Interdisciplinary Research Bugarini A, Pereira VM, Marotta TR,
Schirmer CM, Ogilvy CS, Thomas AJ.
Cummings RD. Stuck on sugars: How Flow diversion for treatment of partially
Cardiac Surgery carbohydrates regulate cell adhesion, thrombosed aneurysms: A multicenter
Ahmed AA, Matyal R, Mahmood F, recognition, and signaling. Glycoconj J cohort. World Neurosurg 2019; in press.
Feng R, Berry GB, Gilleland S, 2019;36(4):241-57.
Khabbaz KR. Impact of left ventricular Kicielinski KP, Ogilvy CS. Role of the
outflow tract flow acceleration on Cutler CE, Jones MB, Cutler AA, Mener A, neurosurgeon in acute ischemic stroke
aortic valve area calculation in Arthur CM, Stowell SR, Cummings RD. treatment from triage to intensive care
patients with aortic stenosis. Echo Res Cosmc is required for T cell persistence unit. Neurosurgery 2019;85(suppl1):
Pract 2019;6(4):97-103. in the periphery. Glycobiology S47-S51.
2019;29(11):776-88.
bidmc.org/surgery Inside Surgery | Spring 2020 — Page 14HOME >
Maragkos GA, Motiei-Langroudi R, cancer of the head and neck: A 3-year Surgical Education
Filippidis AS, Glazer PA, Papavassiliou E. analysis in the inpatient setting. J Plast
Castillo-Angeles M, Calvillo-Ortiz R,
Factors predictive of adjacent segment Reconstr Aesthet Surg 2019; in press.
Barrows C, Chaikof EL, Kent TS. The
disease after lumbar spinal fusion.
Granoff MD, Johnson AR, Lee BT, Padera learning environment in surgery
World Neurosurg 2019; in press.
TP, Bouta EM, Singhal D. A novel clerkship: What are faculty perceptions?
Motiei-Langroudi R, Thomas AJ, Ascanio approach to quantifying lymphatic J Surg Educ 2019; in press.
L, Alturki A, Papavassiliou E, Kasper EM, contractility during indocyanine green
Childs BS, Manganiello MD, Korets R.
Arle J, Alterman RL, Ogilvy CS, Stippler lymphangiography. Plast Reconstr Surg
Novel education and simulation tools in
M. Factors predicting the need for 2019;144(5):1197-1201.
urologic training. Curr Urol Rep
surgery of the opposite side after
Johnson AR, Asban A, Granoff MD, Kang 2019;20(12):81.
unilateral evacuation of bilateral chronic
subdural hematomas. Neurosurgery CO, Lee BT, Chatterjee A, Singhal D. Is
Glass CC, Parsons CS, Raykar NP,
2019;85(5):648-55. immediate lymphatic reconstruction
Watkins AA, Jinadasa SP, Fleishman
cost-effective? Ann Surg 2019; in press.
A, Gupta A. An effective multi-
Ophthalmology Johnson AR, Bravo MG, James TA, Suami modality model for single-session
Ing E, Pagnoux C, Torun N. Advances in H, Lee BT, Singhal D. The all but cricothyroidotomy training for trainees.
the diagnosis of giant cell arteritis. Curr forgotten Mascagni-Sappey pathway: Am J Surg 2019;218(3):613-18.
Opin Ophthalmol 2019;30(6):407-11. Learning from immediate lymphatic
reconstruction. J Reconstr Microsurg Surgical Oncology
Otolaryngology/Head and 2019; in press. Barrows CE, Belle JM, Fleishman A,
Neck Surgery Lubitz CC, James BC. Financial burden
Johnson AR, Fleishman A, Tran BNN,
of thyroid cancer in the United States: An
Naples JG, Berryhill McCarty E. Olfaction Shillue K, Carroll B, Tsai LL, Donohoe KJ,
estimate of economic and psychological
and smell identification tests: A novel James TA, Lee BT, Singhal D. Developing
hardship among thyroid cancer
test that may correlate with cochlear a lymphatic surgery program: A
survivors. Surgery 2019; in press.
implant outcomes. Med Hypotheses first-year review. Plast Reconstr Surg
2019; in press. 2019;144(6):975e-85e. James BC, Timsina L, Graham R, Angelos
P, Haggstrom DA. Changes in total
Naples JG, Miller LE, Ramsey A, Li D. Sparenberg S, Blankensteijn LL, Ibrahim
thyroidectomy versus thyroid lobectomy
Cochlear protein biomarkers as AM, Peymani A, Lin SJ. Risk factors
for papillary thyroid cancer during the
potential sites for targeted inner ear associated with the development of
past 15 years. Surgery 2019;166(1):41-7.
drug delivery. Drug Deliv Transl Res sepsis after reconstructive flap surgery. J
2019; in press. Plast Surg Hand Surg 2019;53(6):328-34. Solis-Velasco MA, Ore Carranza AS,
Stackhouse KA, Verkoulen K, Watkins AA,
Naples JG, Ruckenstein MJ. Cochlear Tran BNN, Chen AD, Granoff MD,
Akhouri V, Callery MP, Kent TS, Moser
implant. Otolaryngol Clin North Am Johnson AR, Kamali P, Singhal D, Lee BT,
AJ. Transversus abdominis plane block
2019; in press. Fukudome EY. Surgical outcomes of
reduces pain and narcotic consumption
sternal rigid plate fixation from 2005 to
Naples JG, Ruckenstein MJ. The after robot-assisted distal
2016 using the American College of
impact and evolution of cranial pancreatectomy. HPB (Oxford)
Surgeons-National Surgical Quality
nerve stimulators in Otolaryngology. 2019;21(8):1039-45.
Improvement Program database. Arch
Otolaryngol Clin North Am 2019; Plast Surg 2019;46(4):336-43. Stackhouse KA, Storino A, Watkins AA,
in press.
Gooding W, Callery MP, Kent TS,
Naples JG, Shah RR, Ruckenstein MJ. Podiatry Sawhney MS, Moser AJ. Biliary palliation
The evolution of presenting signs and Dinh T, Lewis C. Amnion applications in for unresectable pancreatic
symptoms of lateral skull base the foot and ankle. Clin Podiatr Med adenocarcinoma: Surgical bypass or
cerebrospinal fluid leaks. Curr Opin Surg 2019;36(4):563-76. self-expanding metal stent? HPB
Otolaryngol Head Neck Surg (Oxford) 2019; in press.
2019;27(5):344-8. Migonis A, Murano R Jr, Stillman IE, Iorio
M, Giurini JM. A case report and Valero MG, King TA, Pilewskie ML.
Naples JG. The challenges of studying literature review: Intraneural ganglion ASO author reflections: Breast cancer
peripheral vestibular vertigo. Clin Drug cyst causing tarsal tunnel syndrome. J risk assessment in women with LCIS:
Investig 2019; in press. Foot Ankle Surg 2019;58(4):795-801. More work is needed. Ann Surg Oncol
2019; in press.
Plastic and Tellechea A, Bai S, Dangwal S,
Theocharidis G, Nagai M, Koerner S, Zhang JQ, Riba L, Magrini L, Fleishman
Reconstructive Surgery Cheong JE, Bhasin S, Shih TY, Zheng Y, A, Ukandu P, Alapati A, Shanafelt T,
Bravo MG, Granoff MD, Johnson AR, Lee Zhao W, Zhang C, Li X, Kounas K, James TA. Assessing burnout and
BT. Development of a new large animal Panagiotidou S, Theoharides T, Mooney professional fulfillment in breast
model for composite face and whole- D, Bhasin M, Sun L, Veves A. Topical surgery: Results from a national survey
eye transplantation: A novel application application of a mast cell stabilizer of the American Society of Breast
for anatomical mapping using improves impaired diabetic wound Surgeons. Ann Surg Oncol
indocyanine green and liquid latex. healing. J Invest Dermatol 2019; in press. 2019;26(10):3089-98.
Plast Reconstr Surg 2019; in press.
Theocharidis G, Veves A. Autonomic
Egeler SA, Huang A, Johnson AR, Ibrahim nerve dysfunction and impaired diabetic
A, Bucknor A, Peymani A, Mureau MAM, wound healing: The role of neuro-
Lin SJ. Regional incidence of and peptides. Auton Neurosci 2019; in press.
reconstructive management patterns in
melanoma and nonmelanoma skin
Continued on page 16 >
bidmc.org/surgery Inside Surgery | Spring 2020 — Page 15< Continued from page 15 HOME >
Thoracic Surgery and Clinical outcomes and development of a Liang P, O’Donnell TFX, Swerdlow NJ,
postoperative risk stratification model. Li C, Lee A, Wyers MC, Hamdan AD,
Interventional Pulmonology Urol Oncol 2019; in press. Schermerhorn ML. Preoperative risk
Alape D, Singh R, Folch E, Fernandez score for access site failure in
Bussy S, Agnew A, Majid A. Life- Althof S, Osterloh IH, Muirhead GJ, ultrasound-guided percutaneous
threatening multi-level airway stenosis George K, Girard N; PEDRIX Multi- aortic procedures. J Vasc Surg
due to Myhre syndrome. Am J Respir Crit Centre Study Group. Including 2019;70(4):1254-62.
Care Med 2019; in press. Morgentaler A. The oxytocin antagonist
cligosiban fails to prolong intravaginal Maitz MF, Martins MCL, Grabow N,
Majid A, Kheir F, Alape D, Chee A, Parikh ejaculatory latency in men with lifelong Matschegewski C, Huang N, Chaikof EL,
M, DeVore L, Agnew A, Gangadharan S. premature ejaculation: Results of a Barbosa MA, Werner C, Sperling C.
Combined thoracoscopic surgical randomized, double-blind, placebo- The blood compatibility challenge.
stapling and endobronchial valve controlled phase IIb trial (PEDRIX). J Part 4: Surface modification for
placement for lung volume reduction Sex Med 2019;16(8):1188-98. hemocompatible materials: Passive
with incomplete lobar fissures: An and active approaches to guide
experimental pilot animal study. J Carrasquillo RJ, Kohn TP, Cinnioglu C, blood-material interactions. Acta
Bronchology Interv Pulmonol 2019; Rubio C, Simon C, Ramasamy R, Biomater 2019;94:33-43.
in press. Al-Asmar N. Advanced paternal age
does not affect embryo aneuploidy O’Donnell TFX, Patel VI, Deery SE, Li C,
Majid A, Labarca G, Uribe JP, Kheir F, following blastocyst biopsy in egg donor Swerdlow NJ, Liang P, Beck AW,
Pacheco C, Folch E, Jantz MA, Mehta HJ, cycles. J Assist Reprod Genet Schermerhorn ML. The state of complex
Patel NM, Herth FJF, Fernandez-Bussy S. 2019;36(10):2039-45. endovascular abdominal aortic
Efficacy of the Spiration® valve system aneurysm repairs in the Vascular Quality
in patients with severe heterogeneous Golijanin B, Pereira J, Mueller-Leonhard Initiative. J Vasc Surg 2019;70(2):369-80.
emphysema: A systematic review and C, Golijanin D, Amin A, Mega A, Boorjian
meta-analysis. Respiration 2019;22:1-11. SA, Thompson RH, Leibovich BC, Rao V, Liang P, Swerdlow N, Li C,
Gershman B. The natural history of renal Solomon Y, Wyers M, Schermerhorn M.
Mitchell MA, Dhaliwal I, Mulpuru S, cell carcinoma with isolated lymph node Contemporary outcomes after carotid
Amjadi K, Chee A. Early readmission to metastases following surgical resection endarterectomy in high-risk anatomic
hospital in cancer patients with from 2006 to 2013. Urol Oncol and physiologic patients. J Vasc Surg
malignant pleural effusions: Analysis of 2019;37(12):932-40. 2019; in press.
the nationwide readmissions database.
Chest 2019; in press. Kott O, Linsley D, Amin A, Karagounis A, Schermerhorn ML, Liang P, Eldrup-
Jeffers C, Golijanin D, Serre T, Gershman Jorgensen J, Cronenwett JL, Nolan BW,
Singh R, Alape D, de Lima A, Ascanio J, B. Development of a deep learning Kashyap VS, Wang GJ, Motaganahalli RL,
Majid A, Gangadharan SP. Regulatory algorithm for the histopathologic Malas MB. Association of transcarotid
T cells in respiratory health and diseases. diagnosis and Gleason grading of artery revascularization vs transfemoral
Pulm Med 2019;1907807. prostate cancer biopsies: A pilot study. carotid artery stenting with stroke or
Eur Urol Focus 2019; in press. death among patients with carotid
Transplant Surgery artery stenosis. JAMA 2019;322(23):
Pelcovits A, Mueller-Leonhard C, Mega 2313-22.
Rodrigue JR, Boger M, DuBay D,
A, Amin A, Kim SP, Golijanin D,
Fleishman A. Increasing organ donor
Gershman B. Outcomes of upper tract Swerdlow NJ, Lyden SP, Verhagen HJM,
designation rates in adolescents: A
urothelial carcinoma with isolated lymph Schermerhorn ML. Five-year results
cluster randomized trial. Am J Public
node involvement following surgical of endovascular abdominal aortic
Health 2019;109(9):1273-79.
resection: Implications for multi-modal aneurysm repair with the Ovation
Rodrigue JR, Fleishman A, Schold JD, management. World J Urol 2019; in press. abdominal stent graft. J Vasc Surg 2019;
Morrissey P, Whiting J, Vella J, Kayler LK, in press.
Traish AM, Hackett G, Miner M,
Katz DA, Jones J, Kaplan B, Pavlakis M,
Morgentaler A. Cardiovascular and Swerdlow NJ, McCallum JC, Liang P, Li C,
Mandelbrot DA; KDOC Study Group.
cerebrovascular safety of testosterone O’Donnell TFX, Varkevisser RRB,
Patterns and predictors of fatigue
therapy. Am J Med 2019;132(10):e748. Schermerhorn ML. Select type I and
following living donor nephrectomy:
type III endoleaks at the completion of
Findings from the KDOC Study. Am J
Transplant 2019; in press.
Vascular and fenestrated endovascular aneurysm
Endovascular Surgery repair resolve spontaneously. J Vasc Surg
Rodrigue JR, Fleishman A, Sokas CM, 2019;70(2):381-90.
Huynh C, Shih TY, Mammoo A, Samant
Schold JD, Morrissey P, Whiting J, Vella J,
A, Pathan S, Nelson DW, Ferran C, Varkevisser RRB, de Guerre LEMV,
Kayler LK, Katz D, Jones J, Kaplan B,
Mooney D, LoGerfo F, Pradhan- Swerdlow NJ, Dansey K, Latz CA, Liang P,
Pavlakis M, Mandelbrot DA. Rates of
Nabzdyk L. Delivery of targeted gene Li C, Verhagen HJM, Schermerhorn ML.
living kidney donor follow-up: Findings
therapies using a hybrid cryogel-coated The impact of proximal clamp location
from the KDOC Study. Transplantation
prosthetic vascular graft. PeerJ on peri-operative outcomes following
2019;103(7):e209-e210.
2019;7:e7377. open surgical repair of juxtarenal
abdominal aortic aneurysms. Eur J Vasc
Urologic Surgery Lagoo J, Berry WR, Miller K, Neal BJ, Sato Endovasc Surg 2019; in press.
Al-Alao O, Mueller-Leonhard C, Kim SP, L, Lillemoe KD, Doherty GM, Kasser JR,
Amin A, Tucci C, Kott O, Mega A, Chaikof EL, Gawande AA, Haynes AB.
Golijanin D, Gershman B. Clinically Multisource evaluation of surgeon
node-positive (cN+) urothelial behavior is associated with malpractice
carcinoma of the bladder treated with claims. Ann Surg 2019; 270(1):84-90.
chemotherapy and radical cystectomy:
bidmc.org/surgery Inside Surgery | Spring 2020 — Page 16HOME >
For more information about this trial,
visit: canarypass.org or contact Drs.
Wagner or Chang at 617-667-3739.
prostate cancer: clinical criteria and
biomarkers that will enable us to
reliably identify who should receive
treatment right away and who
can be monitored over time, with
the goal of reducing unnecessary
treatment and improving quality of
life,” says Dr. Wagner.
Andrew Wagner, MD, is the BIDMC-site principal investigator of the PASS trial and
Director of Minimally Invasive Urologic Surgery. According to Peter Chang,
MD, MPH, BIDMC co-investigator
and Director of the BIDMC Prostate
PASS Aims to Improve Cancer Center, BIDMC has one
Management of Prostate Cancer of the largest number of patients
enrolled in the PASS trial, with 285
men currently participating and
W hen diagnosed with early-
stage prostate cancer, a
patient has to cope with more than
multi-center, prospective clinical
trial seeking to refine the safety of
active surveillance and discover
others still being enrolled. Study
participants are actively followed
with regular PSA tests, biopsies,
just the fear that such a diagnosis biomarkers that could identify clinical exams, and quality-of-life
invariably instills. He also must which patients with early-stage questionnaires. Because prostate
make a decision that could alter prostate cancer might require early cancer tends to be slow-growing,
the course of his life. treatment. Called the Prostate participants will be followed for
Should he undergo surgical or Cancer Active Surveillance Study up to 25 years so researchers can
radiation treatment, both of which (PASS) and launched in 2008 with better understand the timing of
can negatively impact urinary and a grant from the nonprofit Canary cancer progression. Participants
sexual health? Or instead opt for Foundation, this study is based at whose cancer shows signs of
active surveillance, which involves Fred Hutchinson Cancer Research more aggressive behavior receive
being closely monitored for signs Center in Seattle. appropriate treatment.
that his cancer is becoming more In November 2019, the National One BIDMC patient
aggressive and should be treated? Cancer Institute awarded a five- participating in the PASS trial is
The decision is a tough one. year, $6.7 million UO1 grant to James Zatzos, 71, of Bridgewater,
At least 30 to 50 percent of newly provide infrastructure support for Mass., who was diagnosed five
diagnosed prostate cancer patients the PASS trial, which began with years ago. When Mr. Zatzos
have slow-growing, low-risk cancer six participating sites and now has learned about the PASS study
that does not require treatment right 11 sites throughout the country. from Dr. Wagner, he was all in. “I
away—or perhaps ever. Importantly, The principal investigator is Daniel recommend this to other patients.
the risk of dying from prostate Lin, MD, Director of the Institute of I’m monitored very closely,
cancer with low-risk disease is only Prostate Cancer Research at the educated about my condition,
one percent. Unfortunately, doctors Fred Hutchinson Cancer Research and can undergo my blood work
do not yet understand whose cancer Center and UW Medicine; the locally, so it’s convenient,” he says.
might progress, often leading to BIDMC-site principal investigator Participant Bill Deschenes, 57, of
anxiety and overtreatment. is Andrew Wagner, MD, Director of Wrentham, Mass., feels likewise.
Minimally Invasive Urologic Surgery. “Being in this study gives me peace
Only center in Northeast of mind because I’m followed so
But cancer researchers at BIDMC Reduce unnecessary closely,” he says, adding that he also
and elsewhere hope to change that. treatment appreciates the opportunity to take
Since 2010, BIDMC has been the “This trial, the largest prospective part in a study that may someday
only medical center in the Northeast multi-center study in North America, make treatment decisions easier
to participate in a nationwide will help us find the ‘holy grail’ of for other patients.
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