Infection Current Awareness Update 24/05/2021 - PHE ...
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
Infection Current Awareness Update – 24/05/2021 Welcome to the weekly Infection Current Awareness Update (ICAU), produced by PHE Knowledge and Library Services. The purpose of this update is to provide you with the latest, best evidence about infection, to help you make informed decisions. Please note: PHE KLS has set up a separate COVID-19 Daily Alert of latest research. If you would like to receive this, please email libraries@phe.gov.uk. In addition to this, a page of resources about the coronavirus is available here. If you have any queries, please contact us at libraries@phe.gov.uk, and if you would like to request a literature search, please use the Knowledge and Library Services Enquiries Portal (PHE staff only). Please note that not all the articles and resources referred to in this alert are freely available. Some articles may require an Athens username and password, and for PHE and NHS staff, these can be obtained here. If you do not work for PHE or the NHS, you may want to approach your local health library service to discuss how you may have access to library services. COVID-19 related research • COVID-19 infection - 4 Infection-related guidance • European Centre for Disease Prevention and Control - 2 • Infectious Diseases Society of America - 1 Infection-related journals • American Journal of Infection Control - 3 • BMJ Quality & Safety - current issue - 11 • Clinical Infectious Diseases - Advance Access - 29 • Clinical Infectious Diseases - Current Issue - 3 • Clinical Microbiology and Infection - 11 • Current Opinion in Virology - 3 • Diagnostic Microbiology and Infectious Disease - 8 • Emerging Infectious Diseases Journal - ahead of print - 3 • European Journal of Clinical Microbiology & Infectious Diseases - 9 • Eurosurveillance latest updates - 5 • Hepatology - 1 • Infection - 4 • Infection Control & Hospital Epidemiology - FirstView Article - 14 • Infection Control & Hospital Epidemiology - Current Issue - 4 • International Journal of Infectious Diseases - 17 • Journal of Clinical Microbiology - 30 • Journal of Hospital Infection - 4 • Journal of Infection - 7 • Journal of Infectious Diseases - 3 • Journal of Virology: Articles Published Ahead of Print - 14 • Lancet - 1 • Morbidity and Mortality Weekly Report (MMWR) - 7 • Nature Reviews Microbiology - Current Issue - 4 • New England Journal of Medicine - Current Issue - 1 • Scandinavian Journal of Infectious Diseases: Table of Contents - 8 • Sexually Transmitted Infections current issue - 15
NIS Affiliation
• PubMed: NIS affiliation - 2
COVID-19 related research
COVID-19 infection
Covid-19: Why prioritising prevention matters in a pandemic of cures
20 May 2021
Prevention is better than cure. Simple. Clear. Logical. Except that it is easily overcomplicated,
clouded, and misplaced. When we forget that prevention is better than cure, primary care
becomes an...
"Given the unprecedented investment in #COVID19 preventive
measures, there is an imperative to maximise our learning..." In a new
Correspondence, Samuel Watson and @rjlilford ask: Is it time to
randomise #vaccine allocation? https://t.co/cEy7NklMu2
18 May 2021
"Given the unprecedented investment in #COVID19 preventive measures, there is an
imperative to maximise our learning..." In a new Correspondence, Samuel Watson and
@rjlilford ask: Is it time to randomise #vaccine allocation? https://hubs.li/H0NBtWs0
Did you miss last 'Join the Conversation' webinar? Watch recordings of
the webinar presentations: * Funding announcement from UK NIHR *
Generic medicines for COVID-19: upcoming reviews * Living systematic
review guidance https://t.co/DMycsbNWIY
17 May 2021
Did you miss last 'Join the Conversation' webinar? Watch recordings of the webinar
presentations: * Funding announcement from UK NIHR * Generic medicines for COVID-19:
upcoming reviews * Living systematic review guidance https://buff.ly/3hsfg84
In South Africa, a 2-dose Oxford/AZ vaccine did not prevent mild to
moderate COVID-19 (cases mainly B.1.351 variant)
04 May 2021
Annals of Internal Medicine, Volume 174, Issue 5, Page JC50, May 2021.
[back to top]
Infection-related guidance
European Centre for Disease Prevention and Control
The use of antibody tests for SARS-COV-2 in the context of Digital
Green Certificates
20 May 2021
This brief technical note was developed at the request of the European Commission to inform
the discussion on Digital Green Certificates to facilitate the safe and free movement of
citizens within the EU during the COVID-19 pandemic.
Overview of EU/EEA country recommendations on COVID-19
vaccination with Vaxzevria, and a scoping review of evidence to guide
decision-making
18 May 2021This technical report provides a summary of the evidence available at the time of the
publication and what will be required in the future to support EU/EEA countries taking
decisions on administration of the second dose, following a first dose of Vaxzevria
[back to top]
Infectious Diseases Society of America
RT @RealTimeCOVID19: A key intervention to prevent community
#transmission of #SARSCoV2 is the prompt isolation of people with
active #COVID19 infection. Learn more about #transmission &
#isolation in those w #COVID19 infection. https://t.co/rRUgxwkFBa
#RealTimeCOVID19 @Payal @SHEA_Epi @IDSAInfo
21 May 2021
RT @RealTimeCOVID19: A key intervention to prevent community #transmission of
#SARSCoV2 is the prompt isolation of people with active #COVID19 infection. Learn more
about #transmission & #isolation in those w #COVID19 infection. https://bit.ly/3vaurXQ
#RealTimeCOVID19 @Payal @SHEA_Epi @IDSAInfo
[back to top]
Infection-related journals
American Journal of Infection Control
Investigations of Staphylococcal contamination on environmental
surfaces of a neonatal intensive care unit of a children's hospital
21 May 2021
Hospitals offer numerous environments for bacterial contamination. Within the hospital
environment, intensive care units (ICUs) utilize unique medical devices, and have patients
with infections, higher antibiotic use, and are often immunocompromised. The neonatal
intensive care unit (NICU) offers additional concerns.1
Impact of methods and duration of surgical hand scrub on bacterial
count: A randomized controlled trial
21 May 2021
Surgical hand scrub is the act of scrubbing hands preoperatively in order to eliminate
transient flora and reduce resident hand flora.1,2 Effective implementation of this easy and
inexpensive method to prevent infection is crucial to prevent the transfer of healthcare-
associated infections (HAIs)
PPE Training and the Effectiveness of Universal Masking in Preventing
Exposures: The Importance of the Relationship Between Anesthesia
and Infection Prevention
19 May 2021
Abstract
[back to top]
BMJ Quality & Safety - current issue
Safe care on maternity units: a multidimensional balancing act
19 May 2021
What are the key features of hospitals that consistently deliver safe care on labour and
delivery? This is the primary question posed by Liberati and colleagues in this issue of BMJ
Quality & Safety.1 The authors propose a framework distilled from observations on a group
of high-performing units in the UK participating in a training activity to improve patient safetyHealthcare-associated infections: where we came from and where we are headed 19 May 2021 Healthcare-associated infections (HCAIs) are those infections acquired by an individual who is seeking medical care in any healthcare facility, including acute care hospitals, long-term care facilities (including nursing homes), outpatient surgical centres, dialysis centres or ambulatory care clinics Seven features of safety in maternity units: a framework based on multisite ethnography and stakeholder consultation 19 May 2021 Background Reducing avoidable harm in maternity services is a priority globally. As well as learning from mistakes, it is important to produce rigorous descriptions of ‘what good looks like’. Objective We aimed to characterise features of safety in maternity units and to generate a plain language framework that could be used to guide learning and improvement Association between intrahospital transfer and hospital-acquired infection in the elderly: a retrospective case-control study in a UK hospital network 19 May 2021 Background Intrahospital transfers have become more common as hospital staff balance patient needs with bed availability. However, this may leave patients more vulnerable to potential pathogen transmission routes via increased exposure to contaminated surfaces and contacts with individuals Changing hospital organisational culture for improved patient outcomes: developing and implementing the leadership saves lives intervention 19 May 2021 Background Leadership Saves Lives (LSL) was a prospective, mixed methods intervention to promote positive change in organisational culture across 10 diverse hospitals in the USA and reduce mortality for patients with acute myocardial infarction (AMI) Identifying and encouraging high-quality healthcare: an analysis of the content and aims of patient letters of compliment 19 May 2021 Background Although healthcare institutions receive many unsolicited compliment letters, these are not systematically conceptualised or analysed. We conceptualise compliment letters as simultaneously identifying and encouraging high-quality healthcare Observational study assessing changes in timing of readmissions around postdischarge day 30 associated with the introduction of the Hospital Readmissions Reduction Program 19 May 2021 Background The Hospital Readmissions Reduction Program (HRRP) initially penalised hospitals for excess readmission within 30 days of discharge for acute myocardial infarction (AMI), congestive heart failure (CHF) or pneumonia (PNA) and was expanded in subsequent years to include readmissions for chronic obstructive pulmonary disease, elective total hip arthroplasty, total knee arthroplasty and Systematically capturing and acting on insights from front-line staff: the 'Bedside Learning Coordinator 19 May 2021 Insights from front-line staff are generally agreed to be vital for informing quality improvement. However, health services often struggle to gather internal experience-based insights from staff systematically. When such data are collected, standard, systematic mechanisms are often lacking to act on the insights the data convey Removing hospital-based triage from suspected colorectal cancer pathways: the impact and learning from a primary care-led electronic straight-to-test pathway
19 May 2021
Background The 2-week wait referral pathway for suspected colorectal cancer was
introduced in England to improve time from referral from a general practitioner (GP) to
diagnosis and treatment. Patients are required to be seen by a hospital clinician within 2
weeks if their symptoms meet the criteria set by the National Institute for Health and Care
Excellence (NICE) and to start cancer treatment
Weekly variation in quality of care for acute ST-segment elevation
myocardial infarction by day and time of admission: a retrospective
observational study
19 May 2021
Background The admission time of patients with ST-segment elevation myocardial infarction
(STEMI) may affect the quality of care they receive. This study aimed to explore the pattern
and magnitude of variation in quality of care for patients with STEMI in both the process and
outcome domains. Methods We performed a retrospective study based on STEMI data from
China
Systematic review and meta-analysis of interventions for operating
room to intensive care unit handoffs
19 May 2021
Objective To conduct a systematic review and meta-analysis to ascertain the impact of
operating room (OR) to intensive care unit (ICU) handoff interventions on process-based and
clinical outcomes. Method We included all English language, prospective evaluation studies
of OR to ICU handoff interventions published as original research articles in peer-reviewed
journals
[back to top]
Clinical Infectious Diseases - Advance Access
Risk factors for illness severity among pregnant women with confirmed
SARS-CoV-2 infection – Surveillance for Emerging Threats to Mothers
and Babies Network, 22 state, local, and territorial health departments,
March 29, 2020 -March 5, 2021
22 May 2021
AbstractBackgroundPregnant women with coronavirus disease 2019 (COVID-19) are at
increased risk for severe illness compared with nonpregnant women. Data to assess risk
factors for illness severity among pregnant women with COVID-19 are limited. This study
aimed to determine risk factors associated with COVID-19 illness severity among pregnant
women with SARS-CoV-2 infection
Indication for antibiotic prescription among children attending primary
healthcare services in rural Burkina Faso
21 May 2021
AbstractWe evaluated diagnoses leading to antibiotic use for childrenGenetic and Epidemiologic Analyses of an Outbreak of Pneumocystis jirovecii Pneumonia among Kidney Transplant Recipients in the United States 21 May 2021 AbstractBackgroundPneumocystis jiroveciii is an opportunistic fungus that causes Pneumocystis pneumonia (PCP) in immunocompromised hosts. Over an 11-month period, we observed a rise in cases of PCP among kidney-transplant recipients (KTR), prompting an outbreak investigation.MethodsClinical and epidemiologic data were collected for KTR diagnosed with PCP between July 2019 and May 2020 Unravelling the Impact of Pneumococcal Conjugate Vaccines on Ambulatory Antibiotic Drug Consumption in Young Children: An Interrupted Time Series Analysis 20 May 2021 AbstractBackgroundPneumococcal conjugate vaccines (PCVs) reduce respiratory infections in young children, the main antibiotic consumers. Following PCV implementation, dispensed antibiotic prescription (DAP) rates in young children were expected to decline.MethodsComputerized data on DAP for children 90% for alternative retreatment regimens. Influenza Vaccine Effectiveness for Prevention of Severe Influenza- Associated Illness among Adults in the United States, 2019-2020: A test-negative study 20 May 2021 AbstractBackgroundInfluenza vaccine effectiveness (VE) against a spectrum of severe disease, including critical illness and death, remains poorly characterized.MethodsWe conducted a test-negative study in an intensive care unit (ICU) network at 10 United States hospitals to evaluate VE for preventing influenza-associated severe acute respiratory infection (SARI) during the 2019-2020 season, which Antibiotic utilization in deceased organ donors 20 May 2021 AbstractAntibiotic use in deceased organ donors has not been previously described. In a retrospective cohort of 440 donors, we found 427 (97%) received at least one antibiotic
course, 312 (71%) received broad-spectrum antibiotics, and 61 (14%) received potentially redundant antibiotics during their terminal hospitalization, suggesting a need for stewardship. Factors Associated with Readmission in the US Following Hospitalization with COVID-19 20 May 2021 AbstractBackgroundPatients hospitalized for COVID-19 may experience complications following hospitalization and require readmission. This analysis estimates the rate and risk factors associated with COVID-19-related readmission and inpatient mortality Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients 20 May 2021 AbstractSARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day one after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of IgG and IgA. Beware of biases in observational studies on anti-spike monoclonal antibodies 20 May 2021 Reply to Lapadula, et al 20 May 2021 Population-based estimates of post-acute sequelae of SARS-CoV-2 infection (PASC) prevalence and characteristics 19 May 2021 AbstractBackgroundEmerging evidence suggests many people have persistent symptoms after acute COVID-19 illness. Our objective was to estimate the prevalence and correlates of post-acute sequelae of SARS-CoV-2 infection (PASC).MethodsWe employed a population- based probability survey of adults with COVID-19 in Michigan The effectiveness of the TWO-DOSE BNT162b2 vaccine: analysis of real-world data 17 May 2021 AbstractBackgroundCOVID-19 mRNA vaccines were shown to be highly efficacious in preventing the disease in randomized controlled trials; nonetheless, evidence on the real- world effectiveness of this vaccine is limited. Study objective was to evaluate the effectiveness of BNT162b2 vaccine in preventing SARS-CoV-2 infection and COVID-19- related hospitalization and mortality Previous Syphilis Alters the Course of Subsequent Episodes of Syphilis 17 May 2021 AbstractBackgroundThe influence of previous syphilis on the course of a subsequent episode is unknown.MethodsIndividuals enrolled in a study of cerebrospinal fluid (CSF) abnormalities in syphilis were allowed to enroll in the study again with subsequent syphilis Regional spread of blaNDM-1-containing Klebsiella pneumoniae ST147 in post-acute care facilities 17 May 2021 AbstractBackgroundCarbapenem-resistant Enterobacterales (CRE) harboring blaKPC have been endemic in Chicago-area healthcare networks for more than a decade. During 2016- 2019, a series of regional point prevalence surveys identified increasing prevalence of blaNDM-containing CRE in multiple long-term acute care hospitals (LTACHs) and ventilator- capable skilled nursing facilities (vSNFs) O-antigen targeted vaccines against E. coli may be useful in reducing morbidity, mortality and antimicrobial resistance 17 May 2021 Efficacy of 1g ceftriaxone monotherapy compared to dual therapy with azithromycin or doxycycline for treating extragenital gonorrhea among men who have sex with men
17 May 2021 AbstractBackgroundEvidence on efficacy of high-dose ceftriaxone monotherapy for extragenital Neisseria gonorrhoeae (NG) infection is lacking.MethodsA cohort of men who have sex with men (MSM) were tested for NG/Chlamydia trachomatis (CT) every three months, in a single-center observational study in Tokyo, Japan Cost-effectiveness of tocilizumab in severe COVID-19: to see or not to see 17 May 2021 The effect on combination therapy and antibiotic duration 16 May 2021 Reply to Author 16 May 2021 Tracing people living with HIV who are lost to follow-up at ART programs in Southern Africa: A sampling-based cohort study in six countries 16 May 2021 AbstractBackgroundAttrition threatens the success of antiretroviral therapy (ART). In this cohort study, we examined outcomes of people living with HIV (PLHIV) lost to follow-up (LTFU) 2014-2017 at ART programs in Southern Africa Racial disparities in invasive Haemophilus influenzae disease — United States, 2008–2017 16 May 2021 AbstractBackgroundSince the introduction of Haemophilus influenzae serotype b (Hib) conjugate vaccines in the United States, invasive H. influenzae disease (Hi) epidemiology has changed and racial disparities have not been recently described.MethodsActive population- and laboratory-based surveillance for Hi was conducted through Active Bacterial Core surveillance (ABCs) at 10 U.S. sites Current Paradigms of Combination therapy in Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: Does it Work, Which Combination and For Which Patients? 16 May 2021 AbstractThe last several years have seen an emergence of literature documenting the utility of combination antimicrobial therapy, particularly in the salvage of refractory MRSA bacteremia. Recent clinical data are shaping conundrums of which regimens may be more beneficial, which can be potentially harmful, and which subset of patients stand to benefit from more aggressive treatment regimens than Azithromycin and Ciprofloxacin Treatment Outcomes During an Outbreak of Multidrug-Resistant Shigella sonnei Infections in a Retirement Community—Vermont, 2018 16 May 2021 AbstractBackgroundIn 2018, CDC and the Vermont Department of Health investigated an outbreak of multidrug-resistant Shigella sonnei infections in a retirement community that offered a continuum of care from independent living through skilled nursing care. The investigation identified 24 culture-confirmed cases Microbial Etiologies and Clinical Characteristics of Children Seeking Emergency Department Care due to Vomiting in the Absence of Diarrhea 16 May 2021 AbstractBackgroundAs children with isolated vomiting are rarely able to provide a specimen suitable for routine pathogen testing, we have limited knowledge about their infecting pathogens.MethodsBetween December 2014 and August 2018, children
AbstractWe assess protection from previous SARS-CoV-2 infection in a population of 16,101
university students (2,021 with and 14,080 without previous infection). The risk of re-infection
during the Spring 2021 semester was 2.2% among previously infected students; estimated
protection from previous SARS-CoV-2 infection was 84% (95% CI: 78%-88%).
[back to top]
Clinical Infectious Diseases - Current Issue
In the Literature
18 May 2021
Diffuse Blue Skin in an Adult Male
18 May 2021
A 57-year-old man with a medical history notable for hypertension presented with 10 days of
blue skin discoloration on the bilateral arms and trunk. The discoloration was asymptomatic
without any associated pain or itch. His medications included hydrochlorothiazide,
olmesartan, and amlodipine with no new medications or exposures. A review of systems was
unremarkable
Human T-Cell Lymphotropic Virus/Human Immunodeficiency Virus, and
Hepatitis C Virus Coinfection: Clinical Outcomes After 22 Years of
Follow-up in São Paulo City
02 Mar 2021
TO THE EDITOR—The shortening of survival times of patients living with both human
immunodeficiency virus (HIV) and human T-cell lymphotropic virus (HTLV-1) is a
controversial subject, especially after the widespread introduction of combined antiretroviral
therapy (cART) [1, 2]. More recently, Brites et al
[back to top]
Clinical Microbiology and Infection
Epidemiology, evolution and cryptic susceptibility of methicillin-resistant
Staphylococcus aureus in China: a whole-genome-based survey
21 May 2021
Publication date: Available online 20 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Yan Chen, Lu Sun, Xiaoliang Ba, Shengnan Jiang, Hemu Zhuang,
Feiteng Zhu, Haiping Wang, Peng Lan, Qiucheng Shi, Zhengan Wang, Yiyi Chen, Keren Shi,
Shujuan Ji, Yan Jiang, Mark A. Holmes, Yunsong Yu
Predicting Pseudomonas aeruginosa susceptibility phenotypes from
whole genome sequence resistome analysis
19 May 2021
Publication date: Available online 18 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Sara Cortes-Lara, Ester del Barrio-Tofiño, Carla López-Causapé, Antonio
Oliver, Luis Martínez-Martínez, Germán Bou, Laura Zamorano, Irina Sánchez-Diener, Fátima
Galán, Irene Gracia, Manuel Antonio Rodríguez, Lina Martín, Juan Manuel Sánchez, Laura
Viñuela, Ma Victoria García, José Antonio Lepe,
Intravenous immunoglobulin treatment for patients with severe COVID-
19: a retrospective multi-center study
19 May 2021
Publication date: Available online 19 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Jiao Liu, Yizhu Chen, Ranran Li, Zhixiong Wu, Qianghong Xu, Zhongyi Li,
Djillali Annane, Huibin Feng, Sisi Huang, Jun Guo, Lidi Zhang, Xiaofei Ye, Wei Zhu,
Hangxiang Du, Yong’an Liu, Tao Wang, Limin Chen, Zhenliang Wen, Jean-Louis Teboul,
Dechang Chen
Non-occupational and occupational factors associated with specific
SARS-CoV-2 antibodies among hospital workers – A multicentre cross-
sectional study19 May 2021
Publication date: Available online 19 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Christian R. Kahlert, Raphael Persi, Sabine Güsewell, Thomas Egger,
Onicio B. Leal-Neto, Johannes Sumer, Domenica Flury, Angela Brucher, Eva Lemmenmeier,
J. Carsten Möller, Philip Rieder, Reto Stocker, Danielle Vuichard-Gysin, Benedikt Wiggli,
Werner C
Culture media for clinical bacteriology in low- and middle-income
countries: challenges, best practices for preparation and
recommendations for improved access
19 May 2021
Publication date: Available online 18 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Jeanne Orekan, Barbara Barbé, Sopheap Oeng, Jean-Baptiste Ronat,
Joanne Letchford, Jan Jacobs, Dissou Affolabi, Liselotte Hardy
Long COVID and the brain network of Proust's madeleine: targeting the
olfactory pathway
18 May 2021
Publication date: Available online 17 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Eric GUEDJ, Françoise LAZARINI, Silvia MORBELLI, Mathieu
CECCALDI, Charlotte HAUTEFORT, Aurélie KAS, Thomas RADULESCO, Dominique
SALMON-CERON, Carole ELDIN
“Novel point-of-care biomarker combination tests to differentiate acute
bacterial from viral respiratory tract infections to guide antibiotic
prescribing: A systematic review”
18 May 2021
Publication date: Available online 17 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Henry C. Carlton, Jelena Savović, Sarah Dawson, Philip J. Mitchelmore,
Martha M.C. Elwenspoek
Novel SARS-CoV-2 variants: the pandemics within the pandemic
18 May 2021
Publication date: Available online 17 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Erik Boehm, Ilona Kronig, Richard A. Neher, Isabella Eckerle, Pauline
Vetter, Laurent Kaiser, for the Geneva Center for Emerging Viral Diseases
Uncommon hepatitis C virus among migrant sex workers in Chiangmai,
Thailand
18 May 2021
Publication date: Available online 17 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Sayamon Hongjaisee, Woottichai Khamduang, Patumrat Sripan, Sirinath
Choyrum, Viraporn Thepbundit, Nattapol Kosachunhanan, Nicole Ngo-Giang-Huong, Arunrat
Tangmunkongvorakul
Assessment of the FilmArray ME panel in 4199 consecutively tested
cerebrospinal fluid samples
18 May 2021
Publication date: Available online 17 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Johan Lindström, Kristina Elfving, Magnus Lindh, Johan Westin, Marie
Studahl
Drug reaction with eosinophilia and systemic symptoms (DRESS) in
patients with COVID-19
18 May 2021
Publication date: Available online 17 May 2021Source: Clinical Microbiology and
InfectionAuthor(s): Giuseppe A. Ramirez, Emanuel Della-Torre, Moreno Tresoldi, Paolo
Scarpellini, Fabio Ciceri, Lorenzo Dagna, Mona-Rita Yacoub
[back to top]
Current Opinion in VirologyEditorial overview: Mechanisms in the molecular interactions of plants
with viruses and viroids
23 May 2021
Publication date: August 2021Source: Current Opinion in Virology, Volume 49Author(s):
Taiyun Wei, Shou-Wei Ding
Immune–bacteriophage interactions in inflammatory bowel diseases
23 May 2021
Publication date: August 2021Source: Current Opinion in Virology, Volume 49Author(s):
Lasha Gogokhia, June L Round
Hepatitis B virus–host interactions and novel targets for viral cure
23 May 2021
Publication date: August 2021Source: Current Opinion in Virology, Volume 49Author(s):
Gaëtan Ligat, Eloi R Verrier, Michael Nassal, Thomas F Baumert
[back to top]
Diagnostic Microbiology and Infectious Disease
Impact of RNA degradation on influenza diagnosis in the surveillance
system
23 May 2021
Publication date: August 2021Source: Diagnostic Microbiology and Infectious Disease,
Volume 100, Issue 4Author(s): Hongyan Bai, Jiashen Zhao, Chunyan Ma, Hejiang Wei,
Xiyan Li, Qiongqiong Fang, Peng Yang, Quanyi Wang, Dayan Wang, Li Xin
Evaluation of three immunoassays for the rapid detection of SARS-
CoV-2 antigens
21 May 2021
Publication date: Available online 21 May 2021Source: Diagnostic Microbiology and
Infectious DiseaseAuthor(s): Ilaria Baccani, Fabio Morecchiato, Chiara Chilleri, Chiara
Cervini, Emanuele Gori, Daniela Matarrese, Andrea Bassetti, Manuela Bonizzoli, Jessica
Mencarini, Alberto Antonelli, Gian Maria Rossolini
Enterococcus faecalis in blood cultures- a prospective study on the role
of persistent bacteremia
19 May 2021
Publication date: Available online 18 May 2021Source: Diagnostic Microbiology and
Infectious DiseaseAuthor(s): Karl Oldberg, Magnus Rasmussen
Contribution of rapid lateral flow assays from capillary blood specimens
to the diagnosis of COVID-19 in symptomatic healthcare workers: a
pilot study in a university hospital, Paris, France
19 May 2021
Publication date: Available online 18 May 2021Source: Diagnostic Microbiology and
Infectious DiseaseAuthor(s): Charlotte Charpentier, Gérard Pellissier, Houria Ichou,
Valentine Marie Ferré, Isabelle Larfi, Bao-Chau Phung, Dorothée Vallois, Sylvie LeGac,
Michel Aubier, Diane Descamps, Nadhira Fidouh-Houhou, Elisabeth Bouvet
Pooled Testing Strategies for SARS-CoV-2 diagnosis: A
comprehensive review
18 May 2021
Publication date: Available online 17 May 2021Source: Diagnostic Microbiology and
Infectious DiseaseAuthor(s): Evangeline Ann Daniel, Bennett Henzeler Esakialraj L,
Anbalagan S, Kannan Muthuramalingam, Ramesh Karunaianantham, Lucia Precilla
Karunakaran, Manohar Nesakumar, Murugesan Selvachithiram, Sathyamurthi Pattabiraman,
Sudhakar Natarajan, Srikanth Prasad Tripathy, Luke Elizabeth Hanna
Developing an algorithm for the diagnosis of abnormal vaginal
discharge in a Dutch clinical setting: a pilot study
18 May 2021Publication date: Available online 17 May 2021Source: Diagnostic Microbiology and
Infectious DiseaseAuthor(s): Ellen H.A. van den Munckhof, Rosalie L. van Sitter, Ronald F.
Lamont, Saskia le Cessie, Ed J. Kuijper, Cornelis W. Knetsch, Anco Molijn, Wim G.V. Quint,
Kim E. Boers, Maurine A. Leverstein-van Hall
A rapid and inexpensive protocol to screen for third generation
cephalosporin-resistant and non-fermenting Gram-negative rods
directly in positive blood cultures
17 May 2021
Publication date: Available online 16 May 2021Source: Diagnostic Microbiology and
Infectious DiseaseAuthor(s): Parmeland Laurence, Bourru Thomas, Kyungu Victoria,
Rousseau Nathalie, Gleize Marion, De Beauvoir Charlotte, Pecquet Matthieu
Documentation of a False Positive Lyme Disease Serologic Test in a
Patient with Untreated Babesia Microti Infection Carries Implications for
Accurately Determining the Frequency of Lyme Disease Coinfections
17 May 2021
Publication date: Available online 16 May 2021Source: Diagnostic Microbiology and
Infectious DiseaseAuthor(s): Gary P. Wormser
[back to top]
Emerging Infectious Diseases Journal - ahead of print
Persistence of SARS-CoV-2–Specific IgG in Children 6 Months After
Infection, Australia
20 May 2021
Z. Toh et al.
Neurologic Disease after Yellow Fever Vaccination, São Paulo, Brazil,
2017–2018
18 May 2021
A. Ribeiro et al.
SARS-CoV-2 Superspread in Fitness Center, Hong Kong, China,
March 2021
18 May 2021
D. Chu et al.
[back to top]
European Journal of Clinical Microbiology & Infectious Diseases
Early and specific targeted mass spectrometry-based identification of
bacteria in endotracheal aspirates of patients suspected with ventilator-
associated pneumonia
21 May 2021
Abstract Rapid and reliable pathogen identification is compulsory to confirm ventilator-
associated pneumonia (VAP) in order to initiate appropriate antibiotic treatment. In the
present proof of concept, the effectiveness of rapid microorganism identification with a
targeted bottom-up proteomics approach was investigated in endotracheal aspirate (ETA)
samples of VAP patients
Comparison of nine different commercially available molecular assays
for detection of SARS-CoV-2 RNA
21 May 2021
Abstract To face the COVID-19 pandemic, the need for fast and reliable diagnostic assays
for the detection of SARS-CoV-2 is immense. We describe our laboratory experiences
evaluating nine commercially available real-time RT-PCR assays. We found that assays
differed considerably in performance and validation before routine use is mandatory.Estimation of influenza-attributable burden in primary care from season
2014/2015 to 2018/2019, France
21 May 2021
Abstract Influenza viruses cause seasonal epidemics whose intensity varies according to the
circulating virus type and subtype. We aim to estimate influenza-like illness (ILI) incidence
attributable to influenza viruses in France from October 2014 to May 2019
Performance of the VITEK®2 advanced expert system™ for the
validation of antimicrobial susceptibility testing results
21 May 2021
Abstract Time to reporting antimicrobial susceptibility testing (AST) results to physicians
plays an essential role in antibiotic stewardship programs. Expert software has been
developed for facilitating the microbiologists’ AST review process
Antibody response in patients admitted to the hospital with suspected
SARS-CoV-2 infection: results from a multicenter study across Spain
21 May 2021
Abstract Aim To evaluate the serological response against SARS-CoV-2 in a multicenter
study representative of the Spanish COVID pandemic. Methods IgG and IgM + IgA
responses were measured on 1466 samples from 1236 Spanish COVID-19 patients admitted
to the hospital, two commercial ELISA kits (Vircell SL, Spain) based on the detection of
antibodies against the viral spike protein and
Comparison between Aptima® assays (Hologic) and the CoBAS® 6800
system (Roche) for the diagnosis of sexually transmitted infections
caused by Chlamydia trachomatis , Neisseria gonorrhoeae , and
Mycoplasma genitalium
21 May 2021
Abstract Nowadays, it is of utmost importance to use fully validated assays for molecular-
based diagnosis. In the field of sexually transmitted disease (STD), Roche and Hologic
provide assays for diagnosing Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG),
Mycoplasma genitalium (MG), and Trichomonas vaginalis (TV). A total of 212 clinical
samples were tested
Low prevalence of tissue detection of cefepime and daptomycin used
as empirical treatment during revision for periprosthetic joint infections:
results of a prospective multicenter study
20 May 2021
Abstract Data demonstrating that antibiotics administered intraoperatively in patients with
surgical revision for periprosthetic joint infection achieve concentrations exceeding minimal
inhibitory concentrations of the identified bacteria at the surgical site when the new implant is
inserted are lacking
The importance of Escherichia coli clonal complex 10 and ST131
among Tanzanian patients on antimicrobial resistance surveillance
programs
19 May 2021
Abstract The objective of this study was to characterize antimicrobial resistance (AMR) of
WHO priority 1 critical pathogen (extrapathogenic Escherichia coli (ExPEC), sequence types
(STs), and ST131 clades from patients in Tanzania so as to guide specific antimicrobial
therapies and preventive measures
Comparative activities of sitafloxacin against recent clinical isolates in
hospitals across China
19 May 2021
Abstract Sitafloxacin is one of the newer generation fluoroquinolones. Considering the ever-
changing antimicrobial resistance, it is necessary to monitor the activities of sitafloxacin
against recent pathogenic isolates
[back to top]Eurosurveillance latest updates
Pitfalls of rubella serology while on the brink of elimination: evaluation
of national data, Belgium, 2017
20 May 2021
Background In Belgium, rubella serology is frequently requested in women of childbearing
age, despite high vaccination coverage and a near-absence of congenital rubella cases.
Different test kits are available and should be standardised by an international standard
preparation. Aim To analyse and compare rubella serology practices in Belgian laboratories
Epidemiological characteristics and outcomes of COVID-19 cases:
mortality inequalities by socio-economic status, Barcelona, Spain, 24
February to 4 May 2020
20 May 2021
Background Population-based studies characterising outcomes of COVID-19 in European
settings are limited, and effects of socio-economic status (SES) on outcomes have not been
widely investigated. Aim We describe the epidemiological characteristics of COVID-19 cases,
highlighting incidence and mortality rate differences across SES during the first wave in
Barcelona, Catalonia, Spain
The potential for vaccination-induced herd immunity against the SARS-
CoV-2 B.1.1.7 variant
20 May 2021
We assess the feasibility of reaching the herd immunity threshold against SARS-CoV-2
through vaccination, considering vaccine effectiveness (VE), transmissibility of the virus and
the level of pre-existing immunity in populations, as well as their age structure
Correction for Euro Surveill. 2020;26(19)
20 May 2021
Hepatitis A outbreak associated with consumption of dates, England
and Wales, January 2021 to April 2021
20 May 2021
We report a national hepatitis A virus (HAV) outbreak linked to the consumption of Medjool
dates. Twenty-nine cases of three genetically related sequences have been identified.
Epidemiological investigations identified a suspected product (adjusted odds ratio: 47.36;
95% confidence interval: 1.79–1,256.07; p = 0.021)
[back to top]
Hepatology
Low Incidence of Adverse Outcomes in Adults With Chronic Hepatitis B
Virus Infection in the Era of Antiviral Therapy
21 May 2021
Hepatology, EarlyView.
[back to top]
Infection
C-reactive protein and procalcitonin for antimicrobial stewardship in
COVID-19
22 May 2021
Abstract Purpose Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
coronavirus 2 (SARS-CoV-2) has spread around the world. Differentiation between pure viral
COVID-19 pneumonia and secondary infection can be challenging. In patients with elevated
C-reactive protein (CRP) on admission physicians often decide to prescribe antibiotic therapyBrief report: attitudes towards Covid-19 vaccination among hospital
employees in a tertiary care university hospital in Germany in
December 2020
20 May 2021
Abstract Coronavirus disease 2019 (Covid-19) vaccination is essential to fight the pandemic.
Health care workers (HCWs) are prioritized to get vaccinated, yet uptake of recommended
vaccinations is known to be low in this group. In a tertiary care university hospital with a high
number of Covid-19 patients in intensive care, 59.5% of surveyed staff (N = 2454) were
willing to get vaccinated, 21
COVID-19: fighting the foe with Virchow
19 May 2021
Correction to: Impact of safety warnings for fluoroquinolones on
prescribing behaviour. Results of a cohort study with outpatient routine
data
17 May 2021
A correction to this paper has been published: https://doi.org/10.1007/s15010-021-01616-7
[back to top]
Infection Control & Hospital Epidemiology - FirstView Article
A comparison of coronavirus disease 2019 (COVID-19) versus
influenza during the pandemic: Can we distinguish COVID-19 from flu?
21 May 2021
Published online by Cambridge University Press:
Inactivation of Candida auris and Candida albicans by ultraviolet-C
21 May 2021
Published online by Cambridge University Press:
Can alternative anatomical sites and environmental surveillance
replace perianal screening for multidrug-resistant organisms in nursing
homes?
21 May 2021
Published online by Cambridge University Press:
Does blood on “dirty” instruments interfere with the effectiveness of
sterilization technologies?
21 May 2021
Published online by Cambridge University Press:
Estimating the excess bed days and economic burden of healthcare-
associated infections in Singapore public acute-care hospitals
21 May 2021
Published online by Cambridge University Press:
Pandora’s box in the dental clinic
20 May 2021
Published online by Cambridge University Press:
Efficacy of relatively low-cost ultraviolet-C light devices against Candida
auris
20 May 2021
Published online by Cambridge University Press:
Stethoscope hygiene: A call to action. Recommendations to update the
CDC guidelines
19 May 2021
Published online by Cambridge University Press:
Reporting uncertainty in results—Response to article on copper cold-
spray technology18 May 2021
Published online by Cambridge University Press:
Antibiotic stewardship implementation at hospitals without on-site
infectious disease specialists: A qualitative study
17 May 2021
Published online by Cambridge University Press:
Association between blood transfusion and ventilator-associated
events: a nested case-control study
17 May 2021
Published online by Cambridge University Press:
Evaluating compliance with infection prevention protocols in red-box
rooms via remote video auditing
17 May 2021
Published online by Cambridge University Press:
The impact of vancomycin-resistant Enterococcus (VRE) screening
policy change on the incidence of healthcare-associated VRE
bacteremia
17 May 2021
Published online by Cambridge University Press:
Use of whole-genome sequencing to investigate a cluster of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in
emergency department personnel
04 May 2021
Published online by Cambridge University Press:
[back to top]
Infection Control & Hospital Epidemiology - Current Issue
ICE volume 42 issue 5 Cover and Back matter
19 May 2021
ICE volume 42 issue 5 Cover and Front matter
19 May 2021
An Important Announcement from the World Health Organization:
“Seconds Save Lives—Clean your Hands”: The May 5, 2021, World
Health Organization SAVE LIVES: Clean Your Hands campaign
14 May 2021
Sum of the parts: Ensuring a resilient global drug supply chain
29 Mar 2021
[back to top]
International Journal of Infectious Diseases
Corrigendum to ‘Hospitalization of mild cases of community-acquired
pneumonia decreased more than severe cases during the COVID-19
pandemic.’ [Int J Infect Dise. Vol 106 (2021) P323–328]
23 May 2021
Publication date: June 2021Source: International Journal of Infectious Diseases, Volume
107Author(s): Hiroyuki Nagano, Daisuke Takada, Jung-ho Shin, Tetsuji Morishita, Susumu
Kunisawa, Yuichi Imanaka
Comparison of Piperacillin Plasma Concentrations in a Prospective
Randomized Trial of Extended Infusion versus Intermittent Bolus of
Piperacillin/Tazobactam in Paediatric Patients
23 May 2021Publication date: Available online 21 May 2021Source: International Journal of Infectious DiseasesAuthor(s): Tatchanapong Chongcharoenyanon, Noppadol Wacharachaisurapol, Suvaporn Anugulruengkitt, Passara Maimongkol, Orawan Anunsittichai, Jiratchaya Sophonphan, Tanittha Chatsuwan, Thanyawee Puthanakit Pulmonary Tuberculosis and Management of Contact Patients in a Department of Nephrology and Kidney Transplantation 23 May 2021 Publication date: Available online 21 May 2021Source: International Journal of Infectious DiseasesAuthor(s): Laure Burguet, Alexandre Duvignaud, Duc Nguyen, Marie-Catherine Receveur, Hannah Kaminski, Isabelle Pellegrin, Anne-Marie Rogues, Olivia Peuchant, Karine Moreau, Pierre Merville, Lionel Couzi The burden of active infection and anti-SARS-CoV-2 IgG antibodies in the general population: Results from a statewide sentinel-based population survey in Karnataka, India 23 May 2021 Publication date: Available online 21 May 2021Source: International Journal of Infectious DiseasesAuthor(s): Giridhara R Babu, Rajesh Sundaresan, Siva Athreya, Jawaid Akhtar, Pankaj Kumar Pandey, Parimala S Maroor, M Rajagopal Padma, R Lalitha, Lalitha Krishnappa, Mohammed Shariff, CN Manjunath, Mysore Kalappa Sudarshan, Gopalkrishna Gururaj, Timmanahalli Sobagaiah Ranganath, Kumar DE Vasanth, The role of testosterone in SARS-CoV-2 infection: a key pathogenic factor and a biomarker for severe pneumonia 21 May 2021 Publication date: Available online 20 May 2021Source: International Journal of Infectious DiseasesAuthor(s): Marta Camici, Paolo Zuppi, Patrizia Lorenzini, Liliana Scarnecchia, Carmela Pinnetti, Stefania Cicalini, Emanuele Nicastri, Nicola Petrosillo, Fabrizio Palmieri, Gianpiero D’Offizi, Luisa Marchioni, Roberta Gagliardini, Roberto Baldelli, Vincenzo Schininà, Elisa Pianura, Federica Di Point of Care Real Time PCR-based diagnostic for Kyasanur Forest Disease 21 May 2021 Publication date: Available online 20 May 2021Source: International Journal of Infectious DiseasesAuthor(s): Triparna Majumdar, Anita Shete, Pragya Yadav, Savita Patil, Deepak Mali, Ashwini Waghmare, Pranita Gawande A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts 20 May 2021 Publication date: Available online 20 May 2021Source: International Journal of Infectious DiseasesAuthor(s): Fabian F. Fay, Carlos Arturo Alvarez-Moreno, Pablo E. Bonvehi, Carolina Cucho Espinoza, Marco Luis Herrera Hidalgo, Marcel Marcano-Lozada, Carlos M. Perez, Alvaro Pulchinelli Jr, Klever Vinicio Sáenz-Flor, Antonio Condino-Neto Single-dose BNT162b2 mRNA COVID-19 vaccine significantly boosts neutralizing antibody response in health care workers recovering from asymptomatic or mild natural SARS-CoV-2 infection 20 May 2021 Publication date: Available online 19 May 2021Source: International Journal of Infectious DiseasesAuthor(s): Ilaria Vicenti, Francesca Gatti, Renzo Scaggiante, Adele Boccuto, Daniela Zago, Monica Basso, Filippo Dragoni, Maurizio Zazzi, Saverio Giuseppe Parisi Social media for field epidemiologists (#SoMe4epis): How to use Twitter during the #COVID19 pandemic1 20 May 2021 Publication date: Available online 19 May 2021Source: International Journal of Infectious DiseasesAuthor(s): Charlotte C. Hammer, T. Sonia Boender, Daniel Rh Thomas Non-ABO red cell antibodies and risk of COVID-19
20 May 2021
Publication date: Available online 19 May 2021Source: International Journal of Infectious
DiseasesAuthor(s): Joel G. Ray, Michael Colacci, Michael J Schull, Marian J Vermeulen,
Alison L Park
The changing influenza activity in the Southern hemisphere countries
during the COVID-19 pandemic
20 May 2021
Publication date: Available online 19 May 2021Source: International Journal of Infectious
DiseasesAuthor(s): Jeehyun Kim, Raquel Elizabeth Gómez Gómez, Kwan Hong, Sujin Yum,
Jieun Jang, Byung Chul Chun
Prospective surveillance for invasive Staphylococcus aureus and group
A Streptococcus infections in a setting with high community burden of
scabies and impetigo
20 May 2021
Publication date: Available online 19 May 2021Source: International Journal of Infectious
DiseasesAuthor(s): Li Jun Thean, Adam Jenney, Daniel Engelman, Lucia Romani, Handan
Wand, Jyotishna Mani, Jessica Paka, Tuliana Cua, Sera Taole, Vika Soqo, Aalisha
Sahukhan, Mike Kama, Meciusela Tuicakau, Joseph Kado, Natalie Carvalho, Margot
Whitfeld, John Kaldor, Andrew C. Steer
Day by day symptoms following positive and negative PCR tests for
SARS-CoV-2 in non-hospitalised health-care workers: a 90-day follow-
up study
20 May 2021
Publication date: Available online 20 May 2021Source: International Journal of Infectious
DiseasesAuthor(s): Kent J. Nielsen, Jesper Medom Vestergaard, Vivi Schlünssen, Jens
Peter Bonde, Kathrine Agergård Kaspersen, Karin Biering, Ole Carstensen, Thomas Greve,
Karoline Kærgaard Hansen, Annett Dalbøge, Esben Meulengracht Flachs, Sanne Jespersen,
Mette Lausten Hansen, Susan Mikkelsen, Marianne
Immunological memory and neutralizing activity to a single dose of
COVID-19 vaccine in previously infected individuals
20 May 2021
Publication date: Available online 19 May 2021Source: International Journal of Infectious
DiseasesAuthor(s): Mitnala Sasikala, Jaggaiahgari Shashidhar, Gujjarlapudi Deepika,
Vishnubhotla Ravikanth, Vemula Venkata Krishna, Yelamanchili Sadhana, Kottapalli
Pragathi, Duvvur Nageshwar Reddy
Time-dependent association between cancer and risk of tuberculosis: A
population-based cohort study
20 May 2021
Publication date: Available online 19 May 2021Source: International Journal of Infectious
DiseasesAuthor(s): Bing-Jie Shen, Hsien-Ho Lin
SARS-CoV-2 sero-prevalence among general population and
healthcare workers in India, December 2020 - January 2021
20 May 2021
Publication date: Available online 19 May 2021Source: International Journal of Infectious
DiseasesAuthor(s): Manoj V. Murhekar, Tarun Bhatnagar, Jeromie Wesley Vivian Thangaraj,
V. Saravanakumar, Muthusamy Santhosh Kumar, Sriram Selvaraju, Kiran Rade, C.P. Girish
Kumar, R
Real-world clinical performance of commercial SARS-CoV-2 rapid
antigen tests in suspected COVID-19: A systematic meta-analysis of
available data as per November 20, 2020
18 May 2021
Publication date: Available online 17 May 2021Source: International Journal of Infectious
DiseasesAuthor(s): Johannes Hayer, Dusanka Kasapic, Claudia Zemmrich
[back to top]Journal of Clinical Microbiology Performance of Three Commercial Molecular Diagnostic Assays for the Simultaneous Detection of Mycoplasma genitalium and Macrolide Resistance [Bacteriology] 19 May 2021 The increasing frequency of macrolide resistance is an emerging issue in the treatment of Mycoplasma genitalium infection. Because evaluation of new commercial kits detecting M. genitalium and macrolide resistance is needed, we evaluated the performance and handling characteristics of the Allplex MG & AziR (Seegene), the Macrolide-R/MG ELITe MGB (ELITechGroup), and the ResistancePlus MG FleXible Prevalence of blaCTX-M Genes in Gram-Negative Bloodstream Isolates across 66 Hospitals in the United States [Epidemiology] 19 May 2021 Understanding bacterial species at greatest risk for harboring blaCTX-M genes is necessary to guide antibiotic treatment. We identified the species-specific prevalence of blaCTX-M genes in Gram-negative clinical isolates from the United States Comparative Performance of Latest-Generation and FDA-Cleared Serology Tests for the Diagnosis of Chagas Disease [Parasitology] 19 May 2021 Confirmed diagnosis of chronic Chagas disease (CD) requires positive results by two different IgG serology tests. Variable sensitivity has been reported among tests and in different geographic regions. Inadequate specificity presents a particular challenge in low- prevalence settings such as the United States A Bioinformatics Whole-Genome Sequencing Workflow for Clinical Mycobacterium tuberculosis Complex Isolate Analysis, Validated Using a Reference Collection Extensively Characterized with Conventional Methods and In Silico Approaches [Mycobacteriology and Aerobic Actinomycetes] 19 May 2021 The use of whole-genome sequencing (WGS) for routine typing of bacterial isolates has increased substantially in recent years. For Mycobacterium tuberculosis (MTB), in particular, WGS has the benefit of drastically reducing the time required to generate results compared to most conventional phenotypic methods Clinical and Analytical Evaluation of the Alinity m HR HPV Assay within the VALGENT-3 Framework [Virology] 19 May 2021 Only clinically validated human papillomavirus (HPV) tests should be used in cervical cancer screening. VALGENT provides a framework to validate new HPV tests. In the VALGENT-3 study, the clinical accuracy of the recently launched Abbott Alinity m HR HPV assay (Alinity m) to detect cervical precancerous lesions was assessed against the standard comparator test (Hybrid Capture 2; HC2) and against Correction for Khan et al., "A Multicenter Study To Evaluate Ceftaroline Breakpoints: Performance in an Area with High Prevalence of Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Lineage" [Author Correction] 19 May 2021 Precision Pandemic Preparedness: Improving Diagnostics with Metagenomics [Commentary] 19 May 2021 The threat posed by novel pandemics in the future remains active. Equipping our routine laboratory with clinical metagenomics to detect unknown threats early on offers a considerable advantage and may be feasible and scalable with the ability to identify complicated infectious diseases in routine care
The Brief Case: Disseminated Microsporidiosis with Intestinal Cryptosporidium Coinfection in a Patient with Kaposis Sarcoma and Castleman Disease Presenting with Acute Kidney Injury [Brief Case] 19 May 2021 Predictive Value of Direct Disk Diffusion Testing from Positive Blood Cultures in a Childrens Hospital and Its Utility in Antimicrobial Stewardship [Bacteriology] 19 May 2021 Accurate and early susceptibility results could reduce overuse of broad-spectrum antibiotics for empirical treatment of bacteremia. Direct disk diffusion testing (dDD) using nonstandardized inocula directly from blood cultures could facilitate earlier narrowing of antibiotics Phenotypic and Genomic Profiling of Staphylococcus argenteus in Canada and the United States and Recommendations for Clinical Result Reporting [Bacteriology] 19 May 2021 Staphylococcus argenteus is a newly described species, formerly known as S. aureus clonal complex 75 (CC75). Here, we describe the largest collection of S. argenteus isolates in North America, highlighting identification challenges. We present phenotypic and genomic characteristics and provide recommendations for clinical reporting. Between 2017 and 2019, 22 isolates of S Antimicrobial Susceptibility Profiles To Predict the Presence of Carbapenemase Genes among Carbapenem-Resistant Pseudomonas aeruginosa Isolates [Bacteriology] 19 May 2021 Detection of carbapenem-resistant Pseudomonas aeruginosa (CRPA) with carbapenemase- producing (CP) genes is critical for preventing transmission. Our objective was to assess whether certain antimicrobial susceptibility testing (AST) profiles can efficiently identify CP- CRPA. We defined CRPA as P Emergence of Parechovirus A3 as the Leading Cause of Central Nervous System Infection, Surpassing Any Single Enterovirus Type, in Children in Kansas City, Missouri, USA, from 2007 to 2016 [Epidemiology] 19 May 2021 Picornaviruses, including Enterovirus species A to D (EV) and Parechovirus species A (PeV- A), are the leading reported causes of pediatric central nervous system infections in the United States. We investigated the molecular epidemiology of EV and PeV-A over 10 years in cerebrospinal fluid (CSF) collected from children seen at Children’s Mercy-Kansas City (CMKC) from 2007 through 2016 Specificity of SARS-CoV-2 Real-Time PCR Improved by Deep Learning Analysis [Virology] 19 May 2021 Real-time PCR (RT-PCR) is widely used to diagnose human pathogens. RT-PCR data are traditionally analyzed by estimating the threshold cycle (CT) at which the fluorescence signal produced by emission of a probe crosses a baseline level Four-Hour Immunochromatographic Detection of Intestinal Carriage of Carbapenemase-Producing Enterobacteriaceae: a Validation Study [Bacteriology] 19 May 2021 The increasing incidence of carbapenemase-producing Gram-negative bacilli (C-PGNB) represents a major public health challenge. Rapid detection of digestive colonization with C- PGNB is fundamental to control their spread. We performed the validation of a rapid protocol for C-PGNB detection directly on rectal swabs
Analysis of Yersinia pseudotuberculosis Isolates Recovered from Deceased Mammals of a German Zoo Animal Collection [Clinical Veterinary Microbiology] 19 May 2021 Yersinia pseudotuberculosis is an important pathogen for both humans and animals. It can infect livestock, as well as pets and wild animals. During recent years, a number of reports have described the isolation of Y. pseudotuberculosis from zoo animals, mainly birds and mammals, for which the infection was mostly lethal Evaluation of Diagnostic Accuracy of Eight Commercial Assays for the Detection of Measles Virus-Specific IgM Antibodies [Immunoassays] 19 May 2021 The World Health Organization (WHO) has targeted measles for global eradication through mass immunization. For effective monitoring of eradication targets, high-quality surveillance is needed. The detection of IgM antibodies, specific to the measles virus, with the use of commercial enzyme-linked immunosorbent assays (ELISA or EIA) is broadly used within the WHO global measles and rubella Diagnosis of SARS-CoV-2 Infection with LamPORE, a High-Throughput Platform Combining Loop-Mediated Isothermal Amplification and Nanopore Sequencing [Virology] 19 May 2021 LamPORE is a novel diagnostic platform for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA combining loop-mediated isothermal amplification with nanopore sequencing, which could potentially be used to analyze thousands of samples per day on a single instrument The Genotype-to-Phenotype Dilemma: How Should Laboratories Approach Discordant Susceptibility Results? [Minireviews] 19 May 2021 Traditional culture-based methods for identification and antimicrobial susceptibility testing (AST) of bacteria take 2 to 3 days on average. Syndromic molecular diagnostic panels have revolutionized clinical microbiology laboratories as they can simultaneously identify an organism and detect some of the most significant antimicrobial resistance (AMR) genes directly from positive blood culture Development and Validation of a Multiplex Microsphere Immunoassay Using Dried Blood Spots for SARS-CoV-2 Seroprevalence: Application in First Responders in Colorado, USA [Immunoassays] 19 May 2021 Serological testing of large representative populations for antibodies to SARS-CoV-2 is needed to estimate seroprevalence, transmission dynamics, and the duration of antibody responses from natural infection and vaccination Evaluations of SARS-CoV-2 Serological Assay Performance Need Inclusion of Long-Term Samples [Letter To The Editor] 19 May 2021 False Immunological Detection of CTX-M Enzymes in Klebsiella oxytoca [Letter To The Editor] 19 May 2021 Correction for Cutts et al., "Inactivating Zaire Ebolavirus in Whole-Blood Thin Smears Used for Malaria Diagnosis" [Author Correction] 19 May 2021 Photo Quiz: Significant Inclusions in Polymorphonuclear Leukocytes [Photo Quiz] 19 May 2021 Answer to June 2021 Photo Quiz [Photo Quiz] 19 May 2021
You can also read
