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Available by subscription only
Available by subscription only
Summer Issue 2017
HOW COLLAGEN
PEPTIDES HOLD THE KEY
TO QUALITY AGING
SLOW AND STEADY WINS
THE RACE FOR SUGAR
REDUCTION
Human milk
oligosaccharides
A challenge for the future
LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST
••• show preview
Vitafoods Asia 2017:
New Venue and City,
Bigger and Better Experience
Vitafoods Asia – the only event dedicated to the nutraceutical, functional
food and beverages, and dietary supplement industries in Asia – will be
held in Singapore for the first time ever. Happening at the Sands Expo
and Convention Centre in Marina Bay Sands from 5 – 6 September, the
seventh edition will be twice as large as before, with over 250 exhibiting
companies, and will present more of the best innovations that the
industry has to offer.
Singapore and Beyond and knowledge at the New Exhibitor Pavilion, where new
As Asia’s leading food and nutrition hub, Singapore houses entrepreneurial businesses and start-ups in the industry will be
many R&D centres and regional offices from leading F&B exhibiting for the very first time.
companies around the world. For Vitafoods Asia, this strategic
move will bring in new visitors from other parts of the world The coming edition also offers the highest number of
while maintaining its reach in Asia Pacific. International Pavilions. Visitors planning to source from
specific countries can narrow their search by zooming in on
As with previous editions, the nutraceutical event for the 8 pavilions – Australia, Canada, France, Germany, Japan,
Asia will cover four key industry areas – Ingredients & Poland, Taiwan and USA.
Raw Materials, Contract Manufacturing & Private Label,
Services & Equipment, and Branded Finished Products New Education Opportunities
– offering a more focused and targeted content across all
segments. Designed to facilitate business interactions, these Apart from gaining access to the latest innovations and
areas reflect the diverse nature of the nutraceutical industry networking opportunities, attendees can look forward to new
and the classification will allow visitors to identify exhibitors educational offerings lined up at Vitafoods Asia. This year,
of interest with greater ease. This year, attendees can expect the revamped Vitafoods Asia Conference will be split into
to view a wide portfolio of offerings from a record number of two segments: four 1/2-day Masterclasses and a full-day
over 250 exhibitors from around the world, including major Digestive Health & Microbiome Summit. The conference
manufacturers and service providers like analyze & realize, will feature an impressive panel of global industry experts
AstaReal, Catalent, Gelita, Graminex, Ingredia, KSM, Lesaffre, from countries such as Australia, Germany, Sweden, Thailand,
Sabinsa, Troikaa, and Vidya Herbs. The Netherlands, and USA, across various segments and
job functions. Each unique segment will address the key
Returning Event Highlights challenges within Asia’s nutraceutical, supplement, and
Visitors interested in uncovering the latest launches and functional food industry.
core products can head over to the Inspiration Showcase,
featuring a wide range of products - such as energy drinks, For those seeking complimentary learning opportunities
meal replacement bars, and collagen jellies - that address a on the show floor, two brand-new presentation theatres are
variety of needs. Those seeking the opportunity to see, touch, available. The Innovation Theatre is a two-day programme
and taste the latest functional food and beverages in order to that is fully dedicated to the future of the Asian nutraceutical
make informed purchasing decisions can head to the Tasting and functional nutrition industry. It aims to explore the
Centre, where visitors are also encouraged to vote for their upcoming developments in the industry, namely in the
favourite product in the annual Tasting Centre Awards. categories of Open Innovation, Personalised Nutrition, and
New Technology. Separately, the Vitafoods Asia Life Stages
Attendees looking to keep up-to-date with key developments Theatre is designed to examine on the specific nutrition
in the industry can pay a visit to the Market & Trend Overview requirements throughout the human life stages, focusing on
section. There, experts from Innova Market Insights will offer three core themes – Infant & Maternal Health, Adult Health,
a range of poster and tablet device presentations delving and Healthy Ageing.
into carefully selected health categories to broaden visitor’s
understanding on the pan-Asian market leading ingredients, Lastly, attendees looking for a successful market access
products, and consumer trends. to Asia can also seek regulatory advice at the new Industry
Experts Advice Centre, featuring regional and pan-Asian
The popular Omega-3 Resource Centre also makes a market and regulatory experts. Interested parties can visit
return, bringing new trends and product developments from Vitafoods Asia website prior to the event to secure a free 1-2-1
the market. Industry members can learn all about the Omega-3 consultation.
supply chain and even access market data on selected topics
at the focused knowledge hub. For more information on Vitafoods Asia, visit www.
vitafoodsasia.com.
In addition, attendees can further expand their network
nutraceuticals now 03
contents
03
06
08-09
Show Preview: Vitafoods Asia 2017
Foreword: Vitafoods Asia 2017
How collagen peptides hold the key to quality aging
Editor:
Operations Manager:
Charles Faulkner
Dan Peacock
10-13 Brenntag UK & Ireland: Consultant: Christopher McIntyre
Formulating the future together
Accounts: Steve Clark
14-15 Capsaicinoids’ new role in weight management
16-17 Human milk oligosaccharides - a challenge for the future Designer: Al Knight
18 Tate & Lyle extends clean-label portfolio
20-21 The food matrix effect, beyond the nutrients
22 Prinova aquires Lycored’s UK and China-based premix Published by: Johnson-Johnsen Publishing
manufacturing locations
22 Hauts-de-France, a champion in food processing
6 Victoria Terrace,
24-25 Nutraceuticals market can rely on highest levels of Inverness, IV2 3QA, Scotland.
authenticity via testing and certification Tel: +44(0) 1463 718993
26-27 Dietary Polyphenols as nutraceuticals Fax: +44(0) 1463 229976
30-31 Slow and steady wins the race for sugar reduction
Email: info@nutraceuticalsnow.com
32-33 Heading for the mainstream
34 Fruit d’Or cranberry seed oil approved by Health Canada Website: www.nutraceuticalsnow.com
Printed by: Harrisons
advertisers Available by subscription only
Nutraceuticals Now is a technical review providing the latest
02 VitaFoods Asia information on functional products and ingredients which
04 Supply Side West are defined as having a disease preventing and/or health
06 NSF promoting benefit in addition to their nutritional value.
12 Brenntag It is targeted at manufacturers of food and drink, who are
13 OmniActives producing finished products aimed at the ever increasingly
19 Natural Products Scandinavia health conscious consumer.
23 Indena Any views and/or opinions expressed in the articles in this
28 IFIS magazine are entirely those of the individual authors and do
28 Fi Asia not necessarily express the views of the editorial staff.
29 Food Matters Live
35 Sabinsa ISSN -1478-6605
36 LHC
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••• foreword
Vitafoods Asia 2017: Uncover Opportunities
to Enter Burgeoning Nutraceuticals Market
New Venue and City, Bigger and Better Experience
Come September, Asia’s nutraceutical, functional food and beverages, and dietary
supplement industries will gather in Singapore for Vitafoods Asia, the regions’ only
event dedicated to these markets. Despite what crowd sentiment and ‘common
sense’ say about the global economy, many of those we’ve spoken to have
expressed positivity about the future of their companies.
According to Allied Market Research1, the global supply chain and even access market data on selected topics
nutraceuticals market size is expected to reach $302,306 at the focused knowledge hub.
million by 2022, with a CAGR of 7.04% from 2016 to 2022. In addition, attendees can further expand their network
Asia Pacific is expected to surpass the global growth average and knowledge at the New Exhibitor Pavilion, where new
with a CAGR of 7.33%, making noteworthy contributions to the entrepreneurial businesses and start-ups in the industry will be
global market. exhibiting for the very first time. The coming edition also offers
Increasingly, consumers believe that supplements can help the highest number of International Pavilions. Visitors planning
them achieve their nutrition goals, and this signals a wide open to source from specific countries can narrow their search by
market with plentiful opportunities. Based on our interactions zooming in on the 8 pavilions – Australia, Canada, France,
with industry players, we expect personalised nutrition and Germany, Japan, Poland, Taiwan, and USA.
probiotics to feature strongly in this year’s Vitafoods Asia.
Herbalife revealed the results of its Asia Pacific Balanced New Education Opportunities
Nutrition Survey2 earlier this year, and it showed that one in Apart from gaining access to the latest innovations and
three consumers are keen on personalised nutrition products networking opportunities, attendees can look forward to new
and nutrigenomics. However, due to a lack of practitioners in educational offerings lined up at Vitafoods Asia. This year,
the region, such products have generally been too costly for the revamped Vitafoods Asia Conference will be split into
consumers. Separately, probiotics is likely to remain a popular two segments: four 1/2-day Masterclasses and a full-day
category, given the size of the Asia Pacific market – accounting Digestive Health & Microbiome Summit. Those seeking
for an estimated majority share of 38% in 20163 – and the complimentary learning opportunities on the show floor can
rising awareness of health benefits associated with it. expect two brand-new presentation theatres. The Innovation
This year, Vitafoods Asia will be held in Singapore for the first Theatre is a two-day programme dedicated to the future
time ever. Twice as large as before, with over 250 exhibiting of the Asian nutraceutical and functional nutrition industry,
companies, the seventh edition will present more of the best and it explores the upcoming industry developments in the
innovations that the industry has to offer. As Asia’s leading food categories of Open Innovation, Personalised Nutrition, and
and nutrition hub, Singapore houses many R&D centres and New Technology. Separately, the Vitafoods Asia Life Stages
regional offices from leading F&B companies around the world. Theatre is designed to examine on the specific nutrition
For Vitafoods Asia, this strategic move will bring in new visitors requirements throughout the human life stages, focusing on
from other parts of the world and maintain the show’s reach in three core themes – Infant & Maternal Health, Adult Health,
Asia Pacific. and Healthy Ageing.
As with previous editions, the nutraceutical event for Asia will Last, attendees looking for a successful market access to
cover four key industry areas – Ingredients & Raw Materials, Asia can also seek regulatory advice at the new Industry
Contract Manufacturing & Private Label, Services & Experts Advice Centre, featuring regional and pan-Asian
Equipment, and Branded Finished Products – offering a market and regulatory experts. Interested parties can visit the
more focused and targeted content across all segments. Vitafoods Asia website prior to the event to secure a free 1-2-1
consultation.
Returning Event Highlights My team and I look forward to welcoming industry
Visitors interested in uncovering the latest launches and professionals from all over the world at Vitafoods Asia 2017.
core products can head over to the Inspiration Showcase,
featuring a wide range of products - such as energy drinks, References
meal replacement bars, and collagen jellies - that address a • Allied Market Research, Nutraceuticals Market by Type -
variety of needs. Those seeking the opportunity to see, touch, Global Opportunity Analysis and Industry Forecast, 2014-2022,
and taste the latest functional food and beverages in order to Dec 2016
make informed purchasing decisions can head to the Tasting • Herbalife, Asia Pacific Balanced Nutrition Survey Findings, 5
Centre, where visitors are also encouraged to vote for their April 2017
favourite product in the annual Tasting Centre Awards. • Mordor Intelligence, Asia Pacific Probiotics Market (2017-
Attendees looking to keep up-to-date with key developments 2022), May 2017
in the industry can pay a visit to the Market & Trend Overview
area of the show. There, experts from Innova Market Insights
will offer a range of poster and tablet device presentations Chris Lee
that delve into carefully selected health categories to broaden Managing Director
visitor’s understanding on the pan-Asian market leading Global Health & Nutrition Network
ingredients, products, and consumer trends. Informa Exhibitions
The popular Omega-3 Resource Centre also makes a
return, bringing new trends and product developments from www.vitafoodsasia.com
the market. Industry members can learn all about the Omega-3
06 nutraceuticals now nutraceuticals now 07
How collagen
strength in 60 sarcopenic men aged 65 and older. Overall, double-blinded study on post-menopausal women showed that
the results clearly show that the combination of resistance FORTIBONE® administration statistically significantly increased
exercise and specific collagen peptide the bone mineral density in the spine and the femoral neck
supplementation can strengthen by more than 5% compared to placebo over the period of one
muscular power and fight and prevent year. This study confirms the anabolic effects FORTIBONE®
sarcopenia. has on the bone metabolism.
peptides hold
Q: Science has not yet provided a Q: Women in particular also worry about the condition of
cure for osteoarthritis, another huge their skin as they grow older. How can collagen peptides
age-related health concern. Do you be incorporated into skin health products, and what
believe that collagen peptides could results can consumers expect to see?
provide the breakthrough we have A: Collagen is what gives the skin its firm structure. However,
been waiting for? from the age of 30 onwards collagen synthesis in the dermis is
A: Well, they are not a drug and they reduced. At the same time, the skin suffers from a progressive
the key to
can’t cure osteoarthritis but they can loss of moisture, which makes it increasingly dry. Our collagen
do a lot to reduce or to postpone the peptides in VERISOL® stimulate the fibroblasts in the dermis.
condition. The principal reason for joint This substantially increases the synthesis of collagen, elastin
problems as people age is wear and and proteoglycans, all of which contribute to the skin’s
tear of joint cartilage. In most cases, elasticity. As a result, the epidermis is supported from beneath
the symptoms are treated, rather than and skin sagging is prevented. Clinical studies have been
the cause. At GELITA, we have worked published that prove these positive effects on skin elasticity,
quality aging
hard to develop a solution that tackles wrinkle reduction and the appearance of cellulite-affected skin
this problem in with a daily dose of 2.5 g of VERISOL®.
a completely With regards to applications: all GELITA collagen peptides can
different way. easily be incorporated into a wide variety of products — from
We have pharmaceutical-like applications such as capsules, film-coated
developed a tablets and standard tablets to indulgence products such as
product called chocolate, instant coffee, beauty drinks, shots or even fortified
FORTIGEL®. gummies.
It stimulates
the body’s Q: When sourcing collagen peptides, what should
cartilage cells manufacturers look out for?
to increase A: As with many things in life, not all collagen peptides are
production equal. We would always advise manufacturers to source and
of both use only the products used in the clinical trials. Whatever
As people all over the world realize they are likely to live to a ripe old age, the desire collagen and the intended application, it is essential that the promised
to live better for longer is becoming increasingly important. Collagen peptide expert proteoglycans functionality is based on sound science and has been
— the proven in high quality clinical studies. GELITA’s philosophy
GELITA believes that its multifunctional ingredients are what consumers are looking two major of substantiating all product functionalities on solid science is
for, in more ways than one. Nutraceuticals now speaks to Dr Stephan Hausmanns, components what I believe makes the company the preferred supplier for
that make up healthy aging products.
Vice President BU Health & Nutrition at GELITA, to find out why. almost 90%
Q: How is the desire to live better for longer manifesting very real possibilities for many. of cartilage Reference
1
itself in populations around the world? dry mass. www.iofbonehealth.org/facts-statistics#category-22
A: Consumers are aware that they are likely to live longer than Q: What are the options when it comes to finding solutions In doing so,
their predecessors, and the number of people aged 60 and to these problems? these collagen About GELITA
older is growing faster than any other age group. This has led to A: People who want to stay fit and healthy as they grow older peptides GELITA is the world’s leading manufacturer and supplier of
increased consumer desire to be healthy now and in the future. have several options, from sports and lifestyle interventions considerably improve joint mobility, reduce pain and produce collagen proteins. Providing functional, health and wellbeing
Across the globe, people are taking an increasingly proactive to the use of preventative nutrients. We believe that specific lasting quality of life. We have proven the effectiveness of our benefits, the company’s extensive range of collagen
role in their own health by adopting more nutritious diets and collagen peptides can be a powerful ally for people looking product in joint cartilage recovery in several clinical and pre- proteins provides versatile functionalities in functional foods,
more active lifestyles. At the same time, governments and to take the preventative nutrient approach. With their special clinical studies. nutraceuticals and dietary supplements and offers innovative
health organizations are keen to encourage people to adopt nutritional properties, high quality proteins are important tools opportunities for a wide variety of product development
healthy lifestyles in order to avoid the potentially huge burdens when it comes to effectively improving health and wellbeing. Q: Bone health is a particular concern for women after the options. GELITA offers comprehensive service, support and
that illness and infirmity in older people could place on their In fact, GELITA’s specific collagen peptides are scientifically menopause. Is there anything collagen peptides can do to many years of expertise in collagen protein applications. With
health and social services. proven to be very useful in many serious health issues related help in this respect? its strong commitment to science-based innovation, GELITA
to aging. A: Loss of bone density and stability is a significant problem is continually looking for new solutions for food, as well as
Q: What kind of opportunities does this open up for for many postmenopausal women. It can develop into for health and nutrition applications. The company provides
manufacturers? Q: Can collagen peptides really help to fight serious age- osteoporosis, a bone weakening condition that is actually a its customers with tailor-made formulations and a range of
A: This shift in attitudes has created exciting new opportunities related problems? Aren’t they just good for healthy skin major public health threat for many population groups – not just products that meet and exceed the requirements of each and
for food, beverage and nutraceutical producers. Consumer and nails? post-menopausal women. In fact, the WHO predicts that the every application.
demand for solutions that can tackle age-related conditions A: The potential roles for collagen peptides in supporting health already huge number of men and women with osteoporosis in
and keep people active for longer is growing at an impressive as we age go far beyond skin, nails and outward appearance. the EU will rise to 33.9 million in 2025 – that’s a 23% increase
rate. In order to be able to meet this demand, however, Specific peptides can be tailored to deliver solutions to age- from 2010.1
manufacturers require scientifically proven ingredients that can related problems that could potentially place huge burdens on Bone is a mixture of mineral crystals held in an organic
be incorporated into a wide variety of everyday items. health budgets as well as personal wellbeing. collagen matrix. Without this collagen matrix, the crystals Dr Stephan
are extremely brittle and prone to breakage. Thus, it can
Age-related muscle wasting, or sarcopenia, for instance, is
be seen that collagen is as vital as calcium for bone health.
Hausmanns,
Q: Which aspects of their health in later years are a problem that poses serious concern. As well as causing a
consumers most concerned about? steady loss of lean muscle mass, it is characterized by an We have therefore developed a bone health product called
FORTIBONE®. It stimulates osteoblast activity to increase Vice President BU Health
A: Limited physical performance, loss of muscle tone and skin increase in fat mass and a loss of strength and mobility.
the production of the extracellular bone matrix. In addition, & Nutrition at GELITA
vitality, as well as degenerative joint diseases and cartilage To fight sarcopenia, GELITA has developed specific Bioactive
problems are some of the main concerns that people associate Collagen Peptides® named BODYBALANCE®. A high quality it regulates the degenerative processes that affect bones
with aging – and without some form of intervention, these are study investigating its effects on body composition and muscle by reducing osteoclast-based protease production. A recent
08 nutraceuticals now nutraceuticals now 09
Brenntag UK & Ireland: Formulating the Future Together
Brenntag UK & Ireland is part of an organisation that dates back trends. In many cases there is not just one ingredient that can
close to 150 years. From its headquarters located in Leeds, satisfy all the requirements in an alternative formulation. The
Yorkshire, and strategic sites across the UK & Ireland, Brenntag whole recipe should be reviewed taking into consideration
offers its business partners a wide range of products and value processing conditions and ingredient interaction to arrive to a
added services such as filling, mixing and blending services, tailored, customer specific recommendation.
extensive formulation, technical and regulatory support within The choice of appropriate ingredients depends on the
the Life Science, Environmental and Material Science sectors. positioning or the value/ benefit proposition of a product. Finding
Today we speak to Alastair Nicoll, Business Manager Food & ingredients that meet a specific criteria and still deliver on
Nutrition, on what is the key to Brenntag’s continued success in texture, taste, flavour, shelf life and safety can be a challenge.
the food and beverage industry The right ingredient, in combination with the correct processing,
packaging and storage conditions, helps to ensure product
Alastair says: quality. We help our customers to achieve cost optimisation
Distribution of specialty ingredients across food and and flexibility with alternative ingredients or develop innovative
beverage sectors has been Brenntag’s successful focus for flavour profiles in a range of areas of food design and
several decades. We offer products for all food and beverage technology, health and nutrition, food safety, processing aids.
applications, including meat, poultry & fish processing, bakery,
dairy and ice cream, beverages, confectionery, convenience INNOVATIVE PRODUCT CONCEPTS
foods, fruit and vegetable processing, sports nutrition and I am delighted to announce the launch of a new Brenntag Food
many more. Innovations are developed through the introduction Application Kitchen. We have always taken pride in our ability
of new nutritional and functional ingredients, while new to provide extensive technical support to our customers through solutionising plant, offering our customers a range of calling for more diversified product offerings. Consumption
technologies or processing can also provide opportunities for our network of Food Application Centres across Europe. Our pre-diluted ingredients. All of our Brenntag UK & Ireland is largely driven by external factors that are common across
further optimisation of the formulation. Our specialist technical new UK based facility will allow us to undertake even more distribution sites have gained certification for the British Retail most food categories, such as concerns over healthy eating or
teams work with customers to develop new products and bespoke projects and formulating trials across the variety of Consortium (BRC) which demonstrates our commitment to “Macro Trend of Health”.
new application advantage, whether it is choosing the right food and beverage applications, featuring formulation, product being the custodians of safety for the ingredients supply chain For instance, the bakery market has changed significantly,
ingredients for their products, or developing solutions that are and stability testing. we operate in. as shoppers direct their purchasing process through a prism
tailor-made for each customer’s unique and specific needs. Our Food Application Kitchen is located at our food hub site of health trends as well as price. The increasing demand for
My colleagues can advise the right ingredient combinations, in Widnes, Cheshire, which is also the flagship in our evolving DISCUSSING KEY TRENDS IN THE MARKET natural bakery products that contain ingredients such as fibre
interactions and processing conditions to get ingredients to focus on food, feed and pharmaceutical blends in the UK & Specific market trends depend on the market application, is expected to fuel the demand for bakery products. We have
perform to their fullest. Ireland. The site now incorporates a facility that manufactures however we are continuing to see the focus on ranges for seen ongoing success of using chicory root fibre in bakery
dilutions of acidulants, preservatives and other ingredients at health conscious customers across the food and beverage formulations, as it is rapidly becoming the favoured choice with
CHOOSING THE RIGHT INGREDIENT customer-designated strengths as part of our standard portfolio. sectors. Demand for “well being” or “good for you” products its clean labelling and ability to replace sugar and addition of
Formulation flexibility is one of the key attributes required to are increasing. Fat, salt and sugar reduction, “Free From”, fibre.
react quickly on the raw materials situation and on market Along with Widnes, our Belfast site houses a food clean and clear label continue to be some of the key messages In the beverage market, sugar reduction continues to be one
10 nutraceuticals now nutraceuticals now 11
of the key aspects. Some of the simplest and most
cost effective ways to decrease the sugar without
affecting flavour is to select an intensive sweetener
system. Cellulose gums can help counter the loss of
body following the removal of sugar.
Demand for fibre fortified drinks is also on the
increase. The ever-growing energy drinks market
leads to the need for suppliers to provide bespoke
food blending at an increased output level. We
have seen increased demand for specific vitamin
and mineral blends in beverage to replace those
lost when juices are pressed, heat treated and
transported. Blending of course is not only limited
to powders. From simple blends like a 50% Citric
Acid to solution in bulk, to a more bespoke blend of
sweeteners or preservatives in an IBC- the highest
quality standard such as the BRC accreditation is
key.
Dairy products have always been associated
with health, and are seen as an essential part of a
well-balanced, enjoyable diet. Value, convenience,
health, wellness and even indulgence now actively
influence buying decisions. The texture, mouthfeel,
and comfort of a traditional confectionery product. Ingredients
shelf life and appearance of dairy products such as milk,
such as Inulin from Sensus allow manufacturers remove part
drinking or spoonable yoghurts, and flavoured milk are all key
of the sugar but still deliver a pleasant tasting finished product
factors that consumers are looking for, and multiple benefit
with no changes in the manufacturing process.
claims are on the rise. Low fat and Free From (such as allergy
In my view, a successful product is one which interacts
and gluten free) claims continue to be popular. We are also
with a variety of consumer beliefs and shows the benefits of
seeing digestive/gut health positioning gaining further share
ingredients, and innovation is vital to engage with existing and
of this segment. Again, in case of texture improvement, clean
new potential users. Innovation can be achieved through the
label alternatives, low fat/sugar content for dairy products
introduction of ingredients, new technologies and processing -
– correct choice of ingredients can help deliver the right
or all of these aspects for optimal formulation.
positioning of the product.
A growing consumer trend for healthier foods is now looking
For more information please contact alastair.nicholl@
at sectors that have not traditionally been considered as
brenntag.co.uk.
healthy - in a confectionery market for instance. Consumers
are looking for healthier alternatives that still provide the taste
10 nutraceuticals now nutraceuticals now 13
Capsaicinoids’ New Role in Weight Management – Promoting Healthy Body Composition
By Lynda Doyle
Despite the fact that more and more people are aware of the health implications body fat and improve body composition provide a more comprehensive approach to weight
of weight gain and obesity, they are still a growing problem and projected to management and overall health. Several studies have confirmed that Capsimax supports key
mechanisms for weight management, including increasing lipolysis (the breakdown of fat) and
significantly increase in the coming decade. Diet and exercise often bring little energy expenditure and reducing appetite. A recent study demonstrates that Capsimax not
long-term success, even though many try to lose weight using these methods. only supports weight management but also healthy body composition.
Maintaining consistency with a diet plan is challenging and exercise, even The ABC Benefits of Capsimax
when done regularly, may not significantly impact caloric expenditure to make OmniActive’s Appetite and Body Composition Study (ABC), published in the journal
Appetite and entitled “Effects of twelve weeks of capsaicinoid supplementation on body
a difference. To help, many turn to dietary supplements. One naturally occurring composition, appetite and self-reported caloric intake in overweight individuals,” was a 12-
ingredient comes from red chili pepper (Capsicum) and over the last 40 years, week, randomized, double-blind, placebo-controlled study. Seventy-seven healthy subjects
(mildly overweight but not obese) were assigned to receive one of three protocols: 100mg
research has shown how it supports key aspects of healthy weight management Capsimax (containing 2 mg capsaicinoids), 200 mg Capsimax (containing 4 mg capsaicinoids)
including lipolysis – the breakdown of fat, metabolism (thermogenesis) and or placebo. At baseline, 6 weeks and 12 weeks waist: hip ratio, body composition (via dual energy
x-ray absorptiometry) self-reported calorie intakes and appetite levels were analyzed. The results
Getting to know Capsicum show that by 6-weeks of supplementation, waist: hip ratio significantly decreased in the group
The genus Capsicum is native to the Americas. The active ingredient responsible for their spicy kick is called capsaicin and was taking 100 mg Capsimax and by 12-weeks subjects consuming 200 mg Capsimax consumed
first isolated in 1846. Its chemical structure was elucidated later in 1919. More recent research found that a whole group of less calories per day compared to the placebo group. The results suggest that Capsimax
compounds contribute to the hot sensation and are collectively known as capsaicinoids. They fall into a class called alkaloids supplementation reduces self-reported energy intake after 12-weeks and can significantly
and include capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin and homodihydrocapsaicin. The first three of these reduce the waist-to-hip ratio in healthy individuals.
account for 90% or more of the capsaicinoid concentration in the chili and cayenne pepper varieties (See Figure 1). One gram of Capsaicinoids are a potent class of compounds that has been extensively studied
dried red pepper contains approximately 3 mg of capsaicinoids but the actual amount is highly variable and depends on growing for their weight management benefits. Derived from chili peppers, there are few
locations and conditions. supplements derived from a food commonly consumed throughout the world
that can boost metabolism, increase fat breakdown, reduce appetite and,
now, support healthy body composition by its ability to improve waist-to-hip
ratio. Using OmniActive’s OmniBead™ technology Capsimax provides a
concentrated source of highly active capsicum in a controlled-release
coating without the oral and gastric burning sensation of unprotected
chili peppers. The capsaicinoids found in Capsimax provide a low-dose,
convenient and proven solution for weight management and a healthy
lifestyle.
Figure 1. Structures of the three most abundant capsaicinoids in chili and cayenne peppers. References
1
Centers for Disease Control and Prevention. http://www.cdc.gov/obesity/data/adult.html, 2017.
The Special Action of Capsaicin in the Body 2
3
Sassi F, Devaux M. Obesity update 2012. OCED. http://www.oecd.org/health/49716427.pdf
The body has a special subset of nerve receptors that perceive stimuli such as heat and acid. When these receptors are activated, Szallasi A, Blumberg PM. Lypo. Pharmacol Rev. 1999 Jun;51(2):159-212.
Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight
the body feels a painful burning or itching sensation. A subset of these receptors, called transient receptor potential vanilloid 1 (aka management? A systematic review of the evidence. Appetite. 2012 Oct;59(2):341-8.
TRPV1), can be activated by capsaicinoids and their analogs. These receptors are found throughout the body and especially in 4
De Lourdes Reyes-Escogido, M, Gonzalez-Mondragon, ED and Vazquez-Tzompantzi E.
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Body weight by itself only indicates the combined 9
Bloomer RJ, Canale RE, Shastri S, Suvarnapathki S. Effect of oral intake of capsaicinoid beadlets
weight of all the tissues of the body and is not nearly on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo
controlled, double-blind, cross-over study. Lipids Health Dis. 2010 Jul 15;9:72.
as important as composition. Body composition 10
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describes the relative amount of fat to fat-free mass Nutr. 2010; 92:1089–1093.
(bones, muscles, organs, etc…) and how that fat is
11
Ryan ED, Beck TW, Herda TJ, Smith AE, Walter AA, Stout JR, Cramer JT. Acute effects of a
thermogenic nutritional supplement on energy expenditure and cardiovascular function at rest, during
distributed throughout the body. So, even a healthy low-intensity exercise, and recovery from exercise. J Strength Cond Res. 2009 May;23(3):807-17.
person with seemingly normal weight on the scale 12
Deng Y, Chen F, Juturu V, Forzani E. Capsaicinoids enhance metabolic rate using a novel
may still have an unhealthy body composition. People metabolic tracker Breezing Device: An open-label study. Adv Nutr. 2017;8:5.
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are generally classified as having body composition Matsumoto T, Miyawaki C, Ue H, Yuasa T, Miyatsuji A, Moritani T. Effects of capsaicin-containing
yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean
that is either android (a.k.a. “apple shaped”) or gynoid and obese young women. J Nutr Sci Vitaminol (Tokyo). 2000 Dec;46(6):309-15.
(“pear shaped”). Carrying more weight in the waist 14
Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight
(“apple shaped”) is associated with increased risk management? A systematic review of the evidence. Appetite. 2012 Oct;59(2):341-8.
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cardiovascular disease. The waist-to-hip ratio accounts 16
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of the circumference of the waist to that of the hips. 264e273
17
http://www.fda.gov/ucm/groups/fdagov-public/@fdagov-foods-gen/documents/document/
It provides insight into both the amount of weight a ucm269479.pdf
person carries, how it is distributed in the body and the 18
No authors listed. Final report on the safety assessment of capsicum annuum extract, capsicum
risk of associated illness from excess fat. Therefore annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum
frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Int J
dietary and supplementation interventions that reduces
14 nutraceuticals now nutraceuticals now 15
Human milk oligosaccharides
. . . a challenge for the future
By Dr. Katja Parschat
Deputy Head of Research & Development, Jennewein Biotechnologie GmbH
in turn essential for brain development. on bacterial fermentation, and allows the ton-scale synthesis
Approximately 200 structurally diverse HMOs have been of safe, high-quality HMOs fulfilling all US legal requirements
identified thus far, comprising various monosaccharide for use as a supplement in infant formulae. Jennewein
building blocks such as glucose, galactose, L-fucose, Biotechnologie 2’-fucosyllactose has been granted “generally
N-acetylneuraminic acid and N-acetylglucosamine. HMOs regarded as safe” (GRAS) status for general nutrition,
are the third most abundant component of human breast medical nutrition and use as a dietary supplement, and is also
milk after lactose and lipids, with a concentration of 5–10 compliant with the requirements for classification as kosher
g/L. However, the quantity and composition of HMOs and halal food. As well as its use in infant formulae, Jennewein
depends on the individual and changes during the period Biotechnologie 2’-fucosyllactose is approved as an additive
of lactation. At the beginning of lactation, when the infant is for US medical food products, which benefit patients suffering
most vulnerable to infections, the concentration of HMOs from digestive disorders such as malabsorption. The anti-
can reach 24 g/L in the early milk known as colostrum. inflammatory and prebiotic properties of 2’-fucosyllactose may
Remarkably, both the concentration and diversity of also help to alleviate the symptoms of irritable bowel disease,
carbohydrates appears unique to human breast milk. For by improving the integrity of the mucosal barrier. In Europe,
According to the Centers for Disease Control and Prevention (Atlanta, Georgia, USA), approximately example, the concentration of oligosaccharides in bovine and other markets such as China and Korea, a Novel Food
20% of all global cases of acute gastroenteritis are caused by norovirus infections. Norovirus colostrum is only about 1 g/L, and this declines rapidly during Application for Jennewein Biotechnologie 2’-fucosyllactose
is responsible for more than 650 million infections worldwide every year, 200,000 of which are lactation. The oligosaccharides in bovine milk and the milk is currently pending, whereas the product has already been
fatal. Although norovirus causes diarrheal diseases in all age groups, it is the most common of other domestic ruminants are not only less abundant but approved as a novel food in Israel and Canada.
also less diverse, and in some cases, they differ structurally What is next for Jennewein Biotechnologie? Nature is
cause of diarrheal death in children up to 5 years of age. There is no vaccine against norovirus
from the oligosaccharides in human breast milk. Accordingly, the paradigm, and the HMO story will now move beyond
and no specific treatment for infections. However, recent studies have shown that human milk oligosaccharides from the milk of domestic ruminants are 2’-fucosyllactose to focus on the development of production
oligosaccharides (HMOs), specifically 2’-fucosyllactose and 3- fucosyllactose, may help to prevent not ideal as food additives, particularly for infant formulae. processes for other HMOs, such as neutral HMOs like
norovirus infections by stopping the virus particles from attaching to their receptors on the cell Theoretically, authentic HMOs could be produced by total 3-fucosyllactose, or lacto-N-tetraose and lacto-N-fucopentaose
surface. Norovirus infections begin when the virus binds to glycans expressed on the surface of chemical or enzymatic synthesis, but this is laborious and I, and acidic HMOs like sialyllactoses. Combinations of different
expensive and synthetic HMO supplements are therefore HMOs will make infant formula increasingly similar to breast
mucosal epithelial cells in the digestive tract – the so-called histo-blood group antigens (HBGA). economically unfeasible. What is needed, is an alternative milk, with its highly diverse and complex mixture of functional
Fucosylated HMOs such as 2’-fucosyllactose, 3-fucosyllactose and more complex HMOs containing source of HMOs based on a safe and cost-effective production carbohydrates. Jennewein Biotechnologie will investigate
an alpha 1,2-fucose epitope are structurally similar to these HBGA receptors. This resemblance is the health benefits of HMOs as pure products and
sufficient for the HMOs to act as decoys – thus norovirus particles bind to HBGAs and HMOs in mixtures, collaborating with leading academic institutes
such as the German Cancer Research Center and the
vitro in a similar manner (Weichert et al., 2016, Shang et al., 2013). More importantly, the reduced
Mannheim University Hospital. Ultimately, the company
frequency of diarrhea caused by microbial infections correlates with the content of fucosylated seeks Novel Food status and GRAS approval for other
HMOs in breast milk (Morrow et al., 2004, Yu et al., 2016). HMOs, for general and medical use, and for use in
infant formulae.
By the early 1900s, eminent pediatricians had already norovirus. Gastrointestinal pathogens often bind to glycans
noted the much lower mortality rate of breastfed infants on the surface of the mucosal epithelium, the innermost cell References
compared to bottle-fed infants, and observed a correlation layer which is in direct contact with the contents of the gut. • Weichert, Stefan, et al. “Structural basis for norovirus
between breastfeeding and disease resistance, including Soluble HMOs with similar glycan structures act as adhesion- inhibition by human milk oligosaccharides.” Journal of
resistance to infectious diarrhea. Furthermore, they found blocking decoys to prevent this critical initial stage of the Virology 90.9 (2016): 4843–4848.
important differences in the intestinal microbiota, including infection process. The trisaccharide 2’-fucosyllactose prevents
the predominance of Lactobacillus bifidus (later known as the binding of bacteria such as Campylobacter jejuni, one of
• Shang, Jing, et al. “Identifying human milk glycans
that inhibit norovirus binding using surface plasmon
Bifidobacterium bifidum) in the feces of breastfed infants. This the most harmful pathogens responsible for bacterial diarrhea
resonance.” Glycobiology 23.12 (2013): 1491–1498.
was attributed to an unidentified “bifidus factor”. In the 1950s, (Yu et al., 2016). Other HMOs have been shown to block
evidence began to emerge that the bifidus factor was a specific Escherichia coli, Salmonella fyris and Vibrio cholerae (Coppa • Morrow, Ardythe L., et al. “Human milk
group of carbohydrates in human milk, now known as human et al., 2006). Acidic HMOs similarly block Helicobacter pylori, oligosaccharides are associated with protection against
milk oligosaccharides. These HMOs support the growth of which promotes the development of gastritis and gastric ulcers diarrhea in breast-fed infants.” The Journal of pediatrics
lactobacilli, which in turn inhibit pathogens by outcompeting (Simon et al., 1997). The effectiveness of fucosylated HMOs 145.3 (2004): 297–303.
them for nutrients and by secreting acids (lactic acid and acetic is not limited to viruses and bacteria – HMOs also provide • Yu, Zhuo-Teng, Nanthakumar, N. Nanda, and
acid) that make the environment unfavorable for pathogen passive immunity against the fungus Candida albicans and Newburg, David S.. “The human milk oligosaccharide
growth. Nowadays, it is well known that the diet influences even the phagocytosis of eukaryotic parasites can be hindered process. 2′-fucosyllactose quenches Campylobacter jejuni–induced
the composition of the gut microbiome, not only in infants by the same adhesion-blocking mechanism. In 2016, 2’-fucosyllactose was produced for the first time inflammation in human epithelial cells HEp-2 and HT-29 and
but also in adults. The gut microbiome of breastfed infants Many scientific reports have confirmed the positive effects as a food-grade quality product on a scale sufficient to in mouse intestinal mucosa.” The Journal of Nutrition 146.10
is typically dominated by commensal bacteria of the genera of breast milk and specific HMOs on infant health and meet the demands of the US infant formula market. This (2016): 1980–1990.
Bifidobacterium and Bacteroides due to their competence to development in vitro and in vivo. HMOs have the potential 2’-fucosyllactose product is manufactured by Jennewein • Simon, Paul. M., et al. “Inhibition of Helicobacter pylori
metabolize HMOs. HMOs are not digested by humans, so they to modulate systemic immunity by triggering immune factors Biotechnologie GmbH, a German company founded in 2005 binding to gastrointestinal epithelial cells by sialic acid-
lack any nutritional value and enter the colon largely intact, that influence immune cell population and its functions. HMOs and located in Rheinbreitbach, near the former German capital containing oligosaccharides.” Infection and Immunity 65.2
where they act as prebiotics to enrich the beneficial microbial reduce intestinal inflammation, and by promoting the growth of of Bonn. Jennewein Biotechnologie is the leading company in (1997): 750–757.
population and suppress the growth of harmful bacteria. lactobacilli and bifidobacteria, these bacteria themselves also the production of rare oligosaccharides and monosaccharides
for nutritional, pharmaceutical and medical applications, and
• Coppa, Giovanni V., et al. “Human milk oligosaccharides
As well as inhibiting pathogens indirectly by supporting have a positive influence on innate immunity. Acidic HMOs inhibit the adhesion to Caco-2 cells of diarrheal pathogens:
the growth of commensals, HMOs prevent many pathogens such as sialyllactose may provide the sialic acid required for the technology to achieve this was developed in house by its
Escherichia coli, Vibrio cholerae, and Salmonella fyris.”
from binding to cellular receptors, as discussed above for the biosynthesis of gangliosides and glycoproteins, which are own research and development department. The Jennewein
Pediatric Research 59.3 (2006): 377–382.
Biotechnologie 2’-fucosyllactose production process is based
16 nutraceuticals now nutraceuticals now 17
Tate & Lyle Extends Clean-Label Portfolio with the
launch of CLARIA® Bliss Tapioca-Based Starch in
Europe, Middle East & Africa
Extension to the line will enable manufacturers to formulate products
with cleaner labels in line with consumer demand, while maintaining
excellent taste, texture, colour and performance.
Tate & Lyle PLC (“Tate & Lyle”), a leading global
provider of speciality food ingredients and solutions,
has announced the introduction of its tapioca-based
CLARIA® Bliss starch to the Europe, Middle East &
Africa (EMEA) region, responding to growing demand
from consumers for cleaner label products.
An extension to the line of CLARIA® Functional
Clean-Label Starches, the launch of CLARIA® Bliss
in EMEA follows its debut at the Institute of Food
Technologists Food Expo in Chicago last year.
CLARIA® Bliss has functionalities like modified
tapioca starches and can help manufacturers
develop high quality and great tasting products. With
tolerance to shear, heat and acid, even under extreme
conditions like ultra-high temperatures (UHT) and
homogenisation, CLARIA® Bliss makes it easier than
ever for food manufacturers to develop products with
cleaner labels and differentiated texture.
Its launch follows market research from Innova that
shows the number of food products defined as clean-
label sharply increased in Europe in categories such
as chilled desserts (+54%) or ready meals (+39%)
between 2014 and 2016 .
Yves Maltête, VP Global Product Management,
Texturants at Tate & Lyle, said: “At a time when 86%
of European consumers regard food and beverages
as processed if they contain ingredients they don’t
recognise , CLARIA® Bliss can help manufacturers
maintain great taste in their products. It will also allow
them to simplify their ingredient list in a variety of
applications, including delicate dairy desserts, clear
sauces, chilled ready meals or filling of fresh baked
goods.”
CLARIA® Bliss delivers on the growing tapioca-
based starch trend, which has seen launches of
products including tapioca ingredients increasing
on average by 25% each year since 2010. Tapioca
is popular among manufacturers and consumers
for its clean flavour and colour, soft gel texture and
non-GMO and gluten free attributes. CLARIA® Bliss
thickens and sets to form a soft, translucent gel that is
especially desirable in applications like a dairy custard
or in speciality sauces.
Yves Maltête continued: “There is an enormous
opportunity for our customers around the world
to simplify ingredient lists and take advantage of
demand for cleaner labelled products. We want to
partner with our customers to help them meet these
challenges, and retain their competitive edge locally
and globally. With our expanded CLARIA® line now
including CLARIA® Bliss, it’s easier than ever to make
that a reality.”
For more information on CLARIA® Bliss, please visit
www.clariastarch.com/clariar-bliss.
18 nutraceuticals now nutraceuticals now 25THE FOOD MATRIX EFFECT, BEYOND THE NUTRIENTS polar lipid, synthetic emulsifiers) modulates these phenomena
(8).
Meat products
cardiovascular risk (20).
Finally interventional studies with reduction of saturated
fatty acids and high increase of linoleic acid have no effect or
By Lecerf Jean-Michel, Medical Doctor, Head of the Nutrition Department, Institut Pasteur de Lille
Some process may have an impact on digestibility. In usual impairment on secondary cardiovascular prevention : however
Figure 1 THE NEW DIETARY PYRAMID conditions the impact of cooking on meat protein digestibility is Mediterranean diet intervention (Predimed study) is beneficial
low, but even small differences in digestion rate are sufficient (21).
to affect protein digestion rate (which is better at 90°C, 30 min Conclusion
than at 55°C, 5 min); and affects post-prandial assimilation of The food matrix effect is the new revolution in nutrition science
proteins. (22). It proves the role of the complexity of foods, the role of
NUTRIENTS
NEW DIETARY PYRAMID In elderly, studies have demonstrated than bad chewing process and structure on interaction, bioavailability, biological
efficiency slows down protein meat digestion rate and that effects who finally have clinical and epidemiological impact. So
REFINED OR
mincing comparing to cut meat increases protein digestion and we propose a new dietary pyramid (figure 1).
SKIMMED FOODS
improves post-prandial assimilation of meat proteins (9). More must be still demonstrated but actually it appears that
Moreover there is an interaction with other meat components. food matrix may explain lot of differences between the sum
WHOLE FOODS For instance when extracted from their matrix polyphenol of single nutrients and whole foods. Food science and food
extracts largely decrease the apparent meat protein digestibility. technology must be combined to nutrition in order to improve
FOOD GROUPS Finally processing has an impact on peptide generation: 20% our knowledges and our recommendations.
of identified peptides are reproducibly observed in intestinal References
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of the incidence of cardiovascular disease and that the meat humans comparing to oil. And finally fat emulsion modify post- In an animal study with a drug-induced prostate cancer the in prostate health. Biochim Biophys Acta. 2005 May 30;1740(2):202–5.
fat consumption is associated to an increase of the incidence prandial lipid metabolism, provokes an early enhancement of mortality is lower when tomato powder is given to the animal 20. Bolland MJ, Leung W, Tai V, Bastin S, Gamble GD, Grey A, et al. Calcium
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