From Research to Headache Care and Back and Ottorino Rossi Award
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Irccs mondino foundation october & university of pavia 1st-2nd 2021 Celebrations of the 50 years of the Pavia Headache Centre Academic Year 1970/71 - Academic Year 2020/21 From Research to Headache Care and Back and Ottorino Rossi Award XXXI edition The event will take place in a hybrid format (Aula Berlucchi IRCCS Mondino Foundation & videoconference) www.mondino.it
Ottorino Rossi / Historical notes Ottorino Rossi was born on 17th January, 1877, Ottorino Rossi made many important Since 1990, thanks to an initiative of the in Solbiate Comasco, near Como, Italy. In scientific contributions to the fields then new Scientific Director (prof. Giuseppe 1895 he enrolled at the medical faculty of the of neurology, neurophysiopathology Nappi), the IRCCS Mondino Foundation University of Pavia as a student of the Ghislieri and neuroanatomy. These include: the has held an annual Ottorino Rossi Award College and during his undergraduate years identification of glucose as the reducing agent Conference at which the award is presented was an intern pupil of the Institute of General of cerebrospinal fluid, the demonstration to a scientist who has made an important Pathology and Histology, headed by Camillo that fibres from the spinal ganglia pass into contribution to research in the field of the Golgi. In 1901 Rossi obtained his medical the dorsal branch of the spinal roots, and neurosciences. doctor degree with the highest grades and the description of the cerebellar symptom In the course of its 30-year history, the a distinction. In October 1902 he went on to which he termed “the primary asymmetries Ottorino Rossi Award has, on two occasions, the Clinica Neuropatologica (Hospital for of positions”. Moreover, he conducted been theme based. In the period 2010-2012, Nervous and Mental Diseases) directed by important studies on the immunopathology it was was devoted to The Founders of Casimiro Mondino to continue his studies. of the nervous system, the serodiagnosis Neurology, namely the three founders of the At the same time, he continued to frequent of neurosyphilis and the regeneration of most important Italian Schools of Neurology the Golgi Institute which was the leading the nervous system. He was the author of of the twentieth century, while the awards Italian centre for biological research. Having major scientific works including an extensive assigned from 2017 to 2019 celebrated the completed his clinical preparation in Florence investigation of arteriosclerosis in the brain, Pavia Legacy. This latter series stemmed under Eugenio Tanzi, and in Munich at the L’Arteriosclerosi dei Centri Cerebrali e Spinali from the desire to recognise eminent Institute directed by Emil Kraepelin, he taught (1906), which dealt with the development researchers with strong scientific and cultural at the Universities of Siena, Sassari and, from of lesions of vascular origin. He died in 1936 links with the city of Pavia. 1925, Pavia. In Pavia he was made Rector of at the age of 59, having named the Ghislieri Unfortunately, due to the restrictions the University (serving from 1925 to 1936), College as his heir. Ottorino Rossi was one of imposed by the Covid-19 pandemic, it was not and during his tenure he was instrumental in Camillo Golgi’s most illustrious pupils as well possible to stage the Ottorino Rossi Award getting the buildings of the new San Matteo as one of the most eminent descendants of Conference in 2020. As a result this year, 2021, General Hospital completed. Pavia’s medico-biological tradition. sees the Award entering its fourth decade. 2
Rigmor H. Jensen / Ottorino Rossi Award 2021
Rigmor Højland Jensen was born in 20 PhD students and boasts a sizeable
Denmark in 1954. She obtained her MD scientific output (80-100 publications
degree at the University of Copenhagen in per year). Prof. Jensen’s current research
1981. After completing her basic clinical and interests are headache management,
neurological training, as well as fellowships CSF physiology, idiopathic intracranial
at university hospitals in the Copenhagen hypertension and preclinical models,
area, she qualified as a neurologist. She medication overuse headache and cluster
became an associate professor at the headache. She herself has published
University of Copenhagen in 1997, and in more than 400 scientific papers in peer-
2009 a full professor of headache and reviewed journals.
neurological pain at the same University. Prof. Jensen has worked extensively with
Inspired and mentored by Professor Jes national and international organisations
Olesen, she entered the field of headache in the field of headache care, and in pre- In 2016 she initiated an international
research in the late 1980s, initially focusing and postgraduate education. She has “Master in Headache Disorders” at the
mainly on tension-type headache. In 1988, supervised 28 PhD students and more University of Copenhagen. This two-year
she co-conducted the first epidemiological than 50 undergraduate and postgraduate programme has proved very successful
study on headache disorders based on master’s projects. and is continuing to attract post-graduate
the first International Classification of She is a past president of the European students, mostly neurologists, from
Headache Disorders (ICHD-I). Headache Federation, a former trustee numerous countries.
In 2001, she and Prof. Olesen together and co-chair of the International Headache Rigmor Jensen is a leading figure in
founded the Danish Headache Centre at Society’s Education Committee, and a headache care and research worldwide,
Glostrup Hospital, and a decade later she former Director of EHMTIC – an EHF- and has an extensive international network.
became its director. This multidisciplinary Migraine Trust congress organisation. At She has worked steadily with politics for
academic centre, recipient of a Global present she is director of the Lifting the equal and better access to headache care
Excellence in Health Award, has more than Global Burden of Headache organisation. globally.
3Previous Winners / Ottorino Rossi Award
1990 1998 2005 2013
Vittorio Erspamer Alain Berthoz Jes Olesen Henry Markram
Rome (Italy) Paris (France) Copenhagen (Denmark) Lausanne (Switzerland)
1991 1999 2006 2014
Paolo Pinelli Stanley Finger
Ottar Sjaastad Emmanuele A. Jannini
Milan (Italy) S. Louis (USA)
Trondheim (Norway) L’Aquila (Italy)
1992 2007
Giovanni Di Chiro 2000 Michael A. Moskowitz 2015
Bethesda (USA) John Timothy Boston (USA) Roberto Crea
Greenamyre Hayward (USA)
1993 2008
Atlanta (USA)
Clarence Joseph Gibbs Patricia Smith Churchland 2016
Bethesda (USA) 2001 San Diego (USA) Richard Stanislaus
1994 Salvatore Di Mauro 2009 Joseph Frackowiak
David Zee New York (USA) Stephen P. Hunt Lausanne (Switzerland)
Baltimore (USA) London (UK)
2002 2017
1995 Elio Raviola 2010 Pierluigi Nicotera
Elio Lugaresi Boston (USA) Vincenzo Bonavita Bonn (Germany)
Bologna (Italia) Naples (Italy)
2003 2018
1996 2011
Michael Welch Gianvito Martino
Michel Fardeau Cesare Fieschi
Paris (France) Chicago (USA) Rome (Italy) Milan (Italy)
1997 2004 2012 2019
Salvador Moncada François Boller Giorgio Bernardi Adriano Aguzzi
London (UK) Paris (France) Rome (Italy) Zurich (Switzerland)
45
Background to the conference Five decades have passed since 1970, the year in which Prof. Giuseppe studies, it has progressively expanded its horizons, both temporal and Nappi, then a young university lecturer, founded the Headache and Brain scientific, enriching its experience with nosographic classification Circulation Center at the University of Pavia. Over the years, this center, activities, epidemiological investigations, the development of animal based at the Mondino Foundation, went on to become a “Regional Center and human models of disease, studies involving neurophysiological and of Reference”, an important recognition in the healthcare field. In the course neuroimaging methods, and pharmacological trials. From the passion and of this past half century, scientific knowledge in the field of headaches has enthusiasm of a small founding group of young neurologists (Giorgio Bono, made enormous strides, transforming a disorder sometimes considered Emilia Martignoni, Giuseppe Micieli, Grazia Sances and Giorgio Sandrini), the Cinderella of neurology into a topic of great scientific interest, in a long tradition of research and healthcare, enriched over the years with which discoveries have continued incessantly, leading to a series of major new faces and new ideas, was born. The Pavia Headache Center has trained achievements. These include one of the most advanced nosographic numerous headache experts, and created a network of excellence at classifications in medicine, the identification of specific drugs, and national and European level, thereby consolidating the foundations not only the development of highly innovative, complex and multidisciplinary of its present, but also, more importantly, of its future. In fact, this year, a management approaches. representative of the great Pavia Headache School is set to take the reins This scientific and healthcare revolution has mainly involved two forms of the International Headache Society. of primary headache: migraine and cluster headache, both chronic and To celebrate the 50th anniversary of the Pavia Headache Center, colleagues complex neurological diseases whose multiple symptoms, in addition and friends, from various parts of the world, who have contributed, together to the head pain, reflect the involvement of multiple brain circuits. The with the Pavia School, to the growth of headache science and medicine will development of valid animal models has made it possible to shed light on be getting together, in person and/or virtually, at the Mondino Foundation. different aspects of the neurobiology of cranial pain. We now know, for The event will be an opportunity to testify to the progress made and to instance, that the well-established female prevalence of migraine is due discuss future developments with the Mondino Foundation’s younger to differences in the levels of pain receptors located on the meninges that generation, and with members of of the University of Pavia’s Department surround the brain. The discovery, in the 1980s, of a key molecule mediating of Brain and Behavioral Sciences. head pain led to the creation of drugs (monoclonal antibodies and receptor This event will see the prestigious Ottorino Rossi Award, now in its 31st antagonists) capable of selectively blocking its biological action. In addition, year, awarded to Prof. Rigmor H. Jensen (Department of Internal Medicine the identification of various phases in the migraine attack, together with C, Glostrup Hospital, University of Copenhagen), a researcher of great the focus on the entire spectrum of migraine symptomatology, has allowed international renown in the field of headaches. us to identify the structures responsible for attacks and, through the use In addition, prizes will be awarded to two young researchers, in memory, of sophisticated neurophysiological and neuroimaging methods, made it respectively, of Emilia Martignoni and Paolo Rossi, two colleagues who possible to clarify the temporal sequence of their activation. contributed hugely to the whole scientific community, and the Mondino In all these areas, the Pavia Headache Center has constantly played a role Foundation in particular, both as researchers and clinicians and, more of primary importance. Starting from its first clinical and neurochemical important still, as people. 6
Friday, October 1st
8.45 Welcome 9.50 Chapter 1 - Neurons, vessels and hormones
Francesco Svelto Chairs and discussants: Fabio Blandini (Pavia),
Rector, Pavia University Pietro Cortelli (Bologna)
President, IRCCS Mondino Foundation From aura to Headache: novel concepts
Livio P. Tronconi in understanding the complexity of the process
CEO, IRCCS Mondino Foundation by which CSD activates meningeal nociceptors
Rami Burstein (Boston)
Fabio Blandini
Scientific Director, IRCCS Mondino Foundation Migraine and vascular disease
Hans-Christoph Diener (Essen)
Giuseppe Nappi
Founder, Pavia Headache Centre Role of gender and hormones in migraine
Rossella E. Nappi (Pavia)
9.00 Prologue
11.00 Break
The origins: building a solid foundation for growth
Giorgio Sandrini, Pavia 11.10 Chapter 2 - From genetics to signaling
mechanisms in migraine
9.10 Opening Session - Condensed Lectures:
from basic and clinical intuitions Chairs and discussants: Pierangelo Geppetti
to translational neuroscience (Florence), Armando Genazzani (Novara)
Chairs: Maria Gabriella Buzzi (Rome), Migraine and genes
Messoud Ashina (Copenhagen) Arn van den Maagdenberg (Leiden)
Fifty years of pre-clinical advances The CGRP story
Michael A. Moskowitz (Boston) Peter J. Goadsby (London)
Fifty years of clinical advances Human models of migraine
Jes Olesen (Copenhagen) Messoud Ashina (Copenhagen)
7Friday, October 1st
12.20 Chapter 3 - Biomarkers of migraine: 15.30 Chapter 4 - The future of migraine research:
setting the path the Pavia School continues
Chairs and discussants: Gioacchino Tedeschi Chairs: Giorgio Sandrini (Pavia), Alfredo Costa (Pavia)
(Naples), Filippo M. Santorelli (Pisa) Animal models
Neuroimaging Chiara Demartini (Pavia)
Arne May (Hamburg) Advisor: Peter J. Goadsby (London)
Neurophysiology Neurophysiological investigations
Jean Schoenen (Liège) Roberto De Icco (Pavia)
Genetics Advisor: Jean Schoenen (Liège)
Gisela Terwindt (Leiden)
Neuromodulation
Epigenetics Giuseppe Cosentino (Pavia)
Patricia Pozo-Rosich (Barcelona)
Advisor: David W. Dodick (Phoenix)
Neuroimaging
14.30 XXXI Ottorino Rossi Daniele Martinelli (Pavia)
Award Ceremony Advisor: David Borsook (Boston)
Presentation of the winner
Fabio Blandini (Pavia) Artificial intelligence applied to migraine research
Lecture by the winner Silvia Figini (Pavia)
What about the non-migraine headaches,
are they not relevant? 17.30 "Emilia Martignoni" Memorial Award
Rigmor H. Jensen (Copenhagen) Conferred to an Italian Junior MD
presented by Piera Martignoni
8Saturday, October 2nd
9.00 Treatment of migraine and cluster headache: Come prevenire l'uso eccessivo
which options? di farmaci per l'attacco
Chairs: Vincenzo Guidetti, Paolo Martelletti (Rome) Natascia Ghiotto (Pavia)
Monoclonal antibodies targeting CGRP: Le strategie di gestione della cefalea a grappolo
for whom and for how long? Marta Allena (Pavia)
Grazia Sances (Pavia) La telemedicina nella gestione del paziente
Combining preventive drugs: cefalalgico
when enough is not enough Elena Guaschino (Pavia)
Licia Grazzi (Milano) Social media e rischio di fake news
Gepants in migraine: blurring the lines Cherubino Di Lorenzo (Roma)
between acute and preventive treatment Il punto di vista del paziente
Simona Guerzoni (Modena) Lara Merighi (Ferrara)
Cluster headache: from neuromodulation
to monoclonal antibodies
12.30 “Paolo Rossi” Memorial Award: Winner Lecture
Gianluca Coppola (Roma)
13.00 Acknowledgements & Farewell
10.30 Treatment of migraine and cluster headache:
what matters more for the patients?
In collaboration with Al.Ce. Group-CIRNA Foundation Scientific Supervisor Cristina Tassorelli
(30th anniversary of CIRNA) Director of the Headache and Neurorehabilitation Research
Center IRCCS Mondino Foundation, Pavia; Director of the
Chairs: Giorgio Sandrini, Grazia Sances (Pavia) Department of Brain and Behavioral Sciences, University of Pavia
Scientific Committee Cristina Tassorelli, Roberto De Icco,
Daniele Martinelli, Alessia Putortì (Pavia)
9Speakers and Chairpersons
MARTA ALLENA GIUSEPPE COSENTINO NATASCIA GHIOTTO ARNE MAY FILIPPO M. SANTORELLI
IRCCS Mondino Foundation, IRCCS Mondino Foundation, IRCCS Mondino Foundation, University of Hamburg IRCCS Stella Maris
Pavia (Italy) Pavia (Italy) Pavia (Italy) (Germany) Foundation, Pisa (Italy)
MESSOUD ASHINA ALFREDO COSTA PETER J. GOADSBY LARA MERIGHI JEAN SCHOENEN
University of Copenhagen IRCCS Mondino Foundation, Al.Ce. Group Association, Université de Liège
King's College, London (UK)
Pavia & University of Pavia Ferrara (Italy)
(Denmark) (Belgium)
(Italy) LICIA GRAZZI
FABIO BLANDINI IRCCS Neurological Insitute MICHAEL A. MOSKOWITZ FRANCESCO SVELTO
ROBERTO DE ICCO
IRCCS Mondino Foundation, Carlo Besta Foundation, Massachusetts General IRCCS Mondino Foundation,
IRCCS Mondino Foundation,
Pavia (Italy) Milano (Italy) Hospital, Boston (USA) Pavia & University of Pavia
Pavia (Italy)
(Italy)
DAVID BORSOOK CHIARA DEMARTINI ELENA GUASCHINO GIUSEPPE NAPPI
Harvard Medical School IRCCS Mondino Foundation, già IRCCS Mondino CRISTINA TASSORELLI
IRCCS Mondino Foundation,
Massachusettes General Pavia (Italy) Foundation, Pavia (Italy) IRCCS Mondino Foundation,
Pavia (Italy)
Hospital (USA) Pavia & University of Pavia
CHERUBINO DI LORENZO ROSSELLA E. NAPPI
SIMONA GUERZONI (Italy)
RAMI BURSTEIN Sapienza University of Rome University of Pavia (Italy)
University Hospital
Harvard Medical School, (Italy) GIOACCHINO TEDESCHI
Policlinico di Modena (Italy) JES OLESEN
Boston (USA) HANS-CHRISTOPH DIENER University of Copenhagen Campania University, Naples
University Duisburg-Essen VINCENZO GUIDETTI (Italy)
(Denmark)
MARIA GABRIELLA BUZZI Sapienza University of Rome
(Germany)
IRCCS Santa Lucia (Italy) PATRICIA POZO-ROSICH GISELA TERWINDT
Foundation, Rome (Italy) DAVID W. DODICK Vall d’Hebron University Leiden University Medical
Mayo Clinic, Phoenix (USA) RIGMOR H. JENSEN Hospital Barcelona (Spain) Centre (Netherlands)
GIANLUCA COPPOLA Glostrup Hospital (Denmark)
Sapienza University of Rome SILVIA FIGINI GRAZIA SANCES LIVIO P. TRONCONI
- Polo Pontino, Rome (Italy) University of Pavia (Italy) PAOLO MARTELLETTI IRCCS Mondino Foundation,
IRCCS Mondino Foundation,
Sapienza University of Rome Pavia (Italy) Pavia (Italy)
PIETRO CORTELLI ARMANDO GENAZZANI
Piemonte Orientale (Italy)
Alma Mater Studiorum – GIORGIO SANDRINI ARN VAN DEN
University, Novara (Italy)
University of Bologna DANIELE MARTINELLI già IRCCS Mondino MAAGDENBERG
IRCCS Institute of Neurological PIERANGELO GEPPETTI IRCCS Mondino Foundation, Foundation, Pavia & Leiden University
Science, Bologna (Italy) University of Florence (Italy) Pavia (Italy) University of Pavia (Italy) (Netherlands)
10General information
Accreditamento ECM-CPD Other information
Provider IRCCS Fondazione Mondino n. 5467. Obiettivi formativi Participants Registration
tecnico-professionali n. 18: Contenuti tecnico-professionali The registration is free of charge, but mandatory at the
(conoscenze e competenze) specifici di ciascuna professione, following link: courses.mondino.it/corsi_list.php.
di ciascuna specializzazione e di ciascuna attività ultraspecialistica The credentials to take part in the Videoconference
ivi incluse le malattie rare e la medicina di genere. will be sent by e-mail.
Regardless of the training credits, at the end of the
meeting, it will be possible to request the certificate
Le due giornate sono accreditate in ambito ECM-CPD per le seguenti
of attendance.
figure professionali:
Medico Chirurgo (Biochimica clinica, Epidemiologia, Farmacologia Training office Silvia Molinari
e tossicologia clinica, Genetica medica, Laboratorio di genetica IRCCS Fondazione Mondino – Pavia
medica, Igiene, epidemiologia e sanità pubblica, Medicina generale- phone +39 (0) 382 380 299
medici di famiglia, Medicina fisica e riabilitativa, Medicina interna, formazione.informazione@mondino.it
Neurofisiopatologia, Neurologia, Neuropsichiatria infantile,
Neuroradiologia, Patologia clinica-laboratorio di analisi chimico- Organizing secretariat Bquadro congressi srl
cliniche e microbiologia), Assistente sanitario, Biologo, Farmacista Via F.lli Cuzio 42 - 27100 Pavia - phone +39 (0) 382 302 859
(Farmacia ospedaliera, Farmacia territoriale), Chimico, Fisioterapista, studio@bquadro-congressi.it - www.bquadro-congressi.it
Infermiere, Infermiere pediatrico, Psicologo (psicologia, psicoterapia),
Press office Echo arte e comunicazione
Tecnico della fisiopatologia cardiocircolatoria e perfusione
francesca.monza@echo.pv.it - armando.barone@echo.pv.it
cardiovascolare, Tecnico di neurofisiopatologia, Tecnico sanitario
di radiologia medica, Tecnico sanitario di laboratorio biomedico.
Registration Participants, Speakers and Chairpersons
Per ottenere i crediti formativi è necessario partecipare all’intero Entrance from Via Magenes
programma e rispondere correttamente all’80% delle domande
del test di apprendimento. Official language
Sono stati preassegnati n. 8 crediti ECM-CPD alla prima giornata English is the official language for October 1st
e n. 3 crediti ECM-CPD alla seconda giornata. Italian is the official language for October 2nd
11Under the patronage of
SINS
ITALIAN SOCIETY FOR NEUROSCIENCE
With the unconditional support of
IRCCS Fondazione Mondino
Istituto Neurologico Nazionale
a Carattere Scientifico IRCCS
via Mondino 2
27100 Pavia
echo.pv.it
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