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Beat
heartbreak
forever.
Research Grant
Awards 2018 bhf.org.ukContents
02 Introduction
03 BHF Chairholders
06 Awards made during the year
April 2016 – 31 March 2017
06 Non-clinical Fellowships
10 Clinical Fellowships
12 Regenerative Medicine Centres
12 Infrastructure Grants
13 Special Project Grants
14 Clinical Study Grants
14 Programme Grants
16 New Horizons Grants
16 Translational Awards
16 Project Grants2 British Heart Foundation Research Grant Awards 2017/18 BHF Chairholders 3
Introduction BHF chairholders
Listed by town
In the year April 2017 to March 2018 the British University of Birmingham University of Cambridge
Heart Foundation (BHF) awarded grants The Chair of Cardiovascular Sciences and The Chair of Epidemiology and Medicine
Cellular Pharmacology Held by: Professor J N Danesh MBChB MSc
totalling £108.4 million* for research into the Held by: Professor S P Watson DPhil FMedSci
causes, prevention, diagnosis and treatment BSc PhD FMedSci
Major interests: Cardiovascular epidemiology;
of diseases of the heart and circulation. Major interest: Cellular and molecular biology large-scale studies of genetic and biochemical
of blood platelets in haemostasis and factors.
thrombosis.
University of Cambridge
University of Bristol The Chair of Cardiovascular Medicine
The BHF has five research grant committees, The Clinical Studies Committee held its first The Chair of Cardiac Surgery Held by: Professor Z Mallat MD PhD
each of which meets up to four times a year. meeting in May 2017 to support clinical trials of Held by: Professor G D Angelini
MD MCh FRCS FETCS FMedSci Major interest: Cellular and molecular control
The members of each committee are experts in treatments, diagnostics and other interventions
of immune processes in atherosclerosis
various aspects of basic and clinical and certain observational studies of specific
Major interests: Coronary artery bypass surgery, and vascular inflammation.
cardiovascular research. Applications are sent patient groups. The Committee awarded £3.6
including off-pump techniques and methods to
to independent reviewers before being million to three applications.
assessed by the committee. Judgements are
reduce restenosis; improving surgery for heart University of Cambridge
The Translational Awards Committee awarded defects in infants.
made on factors such as scientific merit, The Chair of Cardiopulmonary Medicine
relevance to cardiovascular disease, timeliness, £1.2 million to five applications for the
relationship to other work in the field, and value development of cardiovascular research University of Bristol Held by: Professor N W Morrell MBBS BSc
MA MD FRCP FMedSci
for money. Shortlisted applicants for through early pre-clinical milestones, with the
The Chair of Congenital Heart Surgery
intermediate and senior Fellowships are aim of advancing the research to be attractive Major interest: Molecular and genetic
Held by: Professor M Caputo MD MCh FRCS
interviewed. for larger follow-on investment. mechanisms of pulmonary arterial hypertension.
from 1 October 2017
In 2017-2018 the Chairs and Programme Grants The Fellowships Committee awarded £32.2
Committee awarded £50.4 million to Personal million to 82 applications, and the Project
Major interests: Cardiac surgical research, University of Edinburgh
particularly in congenital heart disease.
Chairs, Programme Grants, Infrastructure Grants Committee awarded £21.3 million to 98 The Chair of Translational
Grants and other major projects. This included applications. Cardiovascular Sciences
£7.5 million to provide a second round of University of Bristol Held by: Professor A H Baker BSc PhD FMedSci
The pages that follow list BHF chairholders in
funding to three BHF Centres of Regenerative The Chair of Cardiovascular Science
post, and new awards made for Fellowships, Major interest: Gene- and cell-based
Medicine, £3 million towards the National Held by: Professor C Emanueli BSc PhD
Regenerative Medicine Centres, Infrastructure therapies to combat vascular disease.
Prevention Research Initiative, and £2 million
Grants, Special Project Grants, Clinical Study Major interest: Growth and repair of adult
towards Health Data Research UK awards for
Grants, Programme Grants, New Horizons
the analysis of big data. It also included
Grants, Translational Awards and Project
blood vessels: roles of stem cells and University of Edinburgh
£327,054 towards six data science awards angiogenic factors.
Grants. The John Wheatley Chair of Cardiology
jointly funded with The Alan Turing Institute.
There were 31 chairholders (also referred to as
Full details of all types of award offered by the University of Cambridge Held by: Professor D E Newby BA BSc PhD
BM DM DSc FRSE FESC FACC FMedSci
BHF and the application process appear on the
BHF Professors) in post on 31 March 2018. Each The Chair of Cardiovascular Sciences
BHF website bhf.org.uk/research Major interest: Experimental cardiovascular
chairholder is site-visited every five years to Held by: Professor M R Bennett BSc MBChB
assess past research performance, future plans PhD MA FRCP FAHA FMedSci medicine, including studies of air pollution
and proposed expenditure. The visiting team as a risk factor for cardiovascular disease.
includes internationally renowned scientists. Major interest: Molecular mechanisms
controlling smooth muscle cell proliferation, University of Glasgow
ageing and death in atherosclerosis.
The Chair of Cardiovascular Medicine
Held by: Professor R M Touyz BSc MBBCh
MSc PhD FMedSci
Major interest: Vascular mechanisms
of hypertension, particularly the role
of reactive oxygen species.
All of the figures above include supplements made to new and existing grants.
* This figure includes only the expected payments to the next milestone for grants which are conditional upon the
successful achievement of project milestones.4 British Heart Foundation Research Grant Awards 2017/18 BHF Chairholders 5
University of Leeds King’s College London University College London University of Oxford
The Chair of Cardiovascular The Chair of Cardiology The Vandervell Chair of Congenital Heart The Chair of Medicine and Epidemiology
and Diabetes Research Held by: Professor K Otsu MD PhD FAHA Disease (to 30th September 2017) Held by: Professor Sir Rory Collins MSc MBBS
Held by: Professor M T Kearney FMedSci Held by: Professor J E Deanfield BA BChir LMSSA FRCP FMedSci FRS
MB ChB FRCP DM MB FRCP FMedSci
Major interest: Inflammatory mechanisms Major interests: Meta-analysis and large-scale
Major interest: Mechanisms by which insulin in heart failure. Major interest: Evaluating the risk factors for trials in cardiovascular disease; large-scale
resistance and diabetes exacerbate atherosclerosis and quantifying the progression epidemiological studies of risk factors
atherosclerosis. King’s College London of vascular disease in children and biomarkers.
and young adults.
The Chair of Cardiology
University of Leeds University of Oxford
The Chair of Cardiovascular Imaging
Held by: Professor A M Shah MD FRCP
FESC FMedSci
University of Manchester The Chair of Regenerative Medicine
Held by: Professor S Plein MRCP MD PhD The Chair of Cardiac Physiology Held by: Professor P R Riley BSc PhD FMedSci
Major interest: Cellular and molecular biology Held by: Professor D A Eisner MA DPhil
Major interest: Innovative cardiac magnetic of production of reactive oxygen species in FMedSci Major interests: Developmental biology of the
resonance imaging for patient diagnosis the cardiovascular system and their roles heart and its applications to cardiac
and assessment. in atherosclerosis, cardiac hypertrophy Major interest: Cellular and molecular regenerative medicine.
and heart failure. physiology of the role of calcium in control
University of Leicester of heart rhythm. University of Oxford
The Chair of Cardiac Surgery
King’s College London The Chair of Cardiovascular Medicine
Held by: Professor G J Murphy BSc The John Parker Chair of
University of Manchester Held by: Professor H C Watkins MD PhD
MBChB MD FRCS Cardiovascular Sciences The Chair of Cardiology FRCP FMedSci FRS
Held by: Professor Q Xu MBBS MD PhD Held by: Professor B D Keavney BSc BM BCh
Major interest: Strategies to reduce distal MRCP DM FRCP Major interests: Genetics and underlying
organ injury occurring during cardiac surgery. Major interest: Cellular and molecular biology molecular mechanisms in hypertrophic
of stem cells and their importance in Major interest: Genetics of heart disease. cardiomyopathy; genetics of coronary
Imperial College London modulating atherosclerosis and restenosis. artery disease.
The Simon Marks Chair of
University of Oxford
Regenerative Cardiology
King’s College London The Chair of Cardiovascular Medicine
University of Southampton
Held by: Professor M D Schneider The Chair of Cardiovascular Proteomics Held by: Professor S Bhattacharya MBBS The Chair of Cardiovascular Science
MD FMedSci Held by: Professor M Mayr MD PhD from MD MRCP MSc FESC FMedSci Held by: Professor M A Hanson MA DPhil
1 May 2017 CertEd FRCOG
Major interests: Molecular control of cardiac Major interests: Developmental biology of the
myocyte growth and death; strategies for Major interest: Novel methods to detect heart; cardiovascular drug target discovery. Major interest: Molecular mechanisms for
regenerative cardiac medicine. and measure biomarkers of cardiovascular risk. developmental and neonatal origins of adult
University of Oxford cardiovascular disease.
King’s College London Queen Mary, University The Chair of Cardiovascular Medicine
The Chair of Molecular Cardiology of London Held by: Professor B Casadei MD DPhil
University of Swansea
Held by: Professor M Gautel MD PhD FMedSci FRCP FESC FMedSci The Sir Thomas Lewis Chair of
The Chair of Cardiovascular Immunology
Cardiovascular Science
Major interest: Cellular and molecular biology Held by: Professor F M Marelli-Berg MD PhD Major interest: Redox signalling in Held by: Professor A J Williams BA PhD
of the contractile proteins in heart muscle. cardiovascular disease, particularly atrial
Major interest: Control of T lymphocyte homing
fibrillation. Major interests: Molecular biology of calcium
to the heart in rejection, autoimmunity and
flux through the ryanodine receptor in cardiac
inflammation.
University of Oxford myocytes and its disturbance in arrhythmia.
The Field Marshal Earl Alexander
Chair of Cardiovascular Medicine
Held by: Professor K M Channon MD FRCP
FMedSci
Major interests: Redox signalling in
atherosclerosis; using genetics and genomics
to discover novel molecular pathways in
atherosclerosis.6 British Heart Foundation Research Grant Awards 2017/18 Fellowships 7
Awards made during the year
1 April 2017 – 31 March 2018
Fellowships Immediate Postdoctoral Basic Science Research Fellowships
Listed alphabetically by Institute Reference number Name Institution Grant title Total
FS/18/5/33319 Dr M Katsoulis University Weight change and the onset and progression of £246,519
Non-clinical Fellowships PhD College London cardiovascular diseases in large-scale electronic
Senior Basic Science Research Fellowships health records. 4 years
Reference number Name Institution Grant title Total
FS/17/59/33117 Dr D Tsiantoulas University of The role of APRIL (A Proliferation Inducing Ligand) £240,221
FS/18/1/33234 Dr J Johnson University The role of the GM-CSF receptor CSF2RA in £1,046,617 BSc PhD Cambridge in myocardial infarction. 3 years
MSc PhD of Bristol inflammatory cardiovascular diseases. 5 years
FS/18/24/33424 Dr R Tyser University Initiation of the first heartbeat: from single cell £267,013
FS/18/19/33371 Dr M Clarke University of Do IL-1R2 and inflammatory caspases regulate £479,983 BSc PhD of Oxford calcium oscillations to propagating waves. 4 years
BSc PhD Cambridge IL-1 in senescence and atherosclerosis? 4 years
FS/17/37/32937 Dr P Collings University Combined associations of sleep duration, £198,344
FS/17/35/32929 Dr S De Val University Determining the regulatory pathways controlling £1,150,716 BSc MSc MPhil of York sedentariness and intensity-specific physical activity
BSc PhD of Oxford venous and lymphatic vessel growth and their role PhD with non-communicable disease risk markers in
during heart development and regeneration. childhood. 4 years
5 years
4-year PhD Studentships
FS/17/55/33100 Dr D Sparrow University Investigation of the mechanisms of environmental £940,865 Reference number Name Institution Grant title Total
BSc PhD of Oxford causes of congenital heart disease. 5 years
FS/17/64/33476 Prof S Harding Imperial College ICL 1st intake 2017 – 4-year PhD Studentship (4th) £669,224
Intermediate Basic Science Research Fellowships BSc PhD London Scheme: Mr Alexander Ainscough; Ms Julia Garcia;
Ms Jennifer Veneta Todorova; Ms Tamzin Zawadzki.
Reference number Name Institution Grant title Total 4 years
FS/17/36/32874 Dr R Charles King's College Activation of soluble epoxide hydrolase by intra- £672,733 FS/17/65/33481 Prof M Mayr King's College KCL 1st intake 2017 – 4-year PhD Studentship (4th) £661,580
PhD London protein disulfide formation: role in regulating MD PhD London Scheme: Ms Jessica Chandler; Mr Daniel Koch; Mr
cardiovascular function in health and disease. Mihai Pruna; Ms Ella Reed. 4 years
5 years
FS/17/69/33484 Prof A Ahluwalia Queen Mary, QMUL 1st intake 2017 – 4-year PhD Studentship (4th) £649,024
FS/17/57/32934 Dr M Stroud King's College Understanding the role of the nuclear envelope in £719,417 BSc PhD University of Scheme: Mr Joshua Dignam; Ms Shireen Mohammad;
BSc PhD London cardiovascular development and disease. 5 years London Ms Nur Mousa; Mr Stefan Russo.
4 years
FS/18/20/33449 Dr M Nixon University Adipose glucocorticoid exposure is regulated by £675,929
BSc PhD of Edinburgh proteolytic cleavage of corticosteroid binding FS/17/70/33482 Prof A Hughes University UCL 1st intake 2017 – 4-year PhD Studentship (4th) £663,924
globulin (CBG). 5 years BSc MBBS PhD College London Scheme: Ms Annalisa Bettini; Ms Jasmine Gratton; Ms
Maria Maranon; Mr Michael Magnussen. 4 years
FS/17/56/32925 Dr N Helassa University CALM HEART. Investigating the role of calmodulin £578,581
PhD of Liverpool in cardiac arrhythmia. 5 years FS/17/60/33474 Prof A Poole University Bristol 1st intake 2017 – 4-year PhD Studentship (4th) £610,876
MA PhD VetMB of Bristol Scheme: Ms Tessa Forbes; Mr Michael Mosley; Ms
FS/18/4/33310 Dr C Pinali University of An ultrastructural study to elucidate how £723,660 FBPhS MRCVS Audrys Pauza; Mr Kurt Taylor. 4 years
PhD Manchester proteoglycans determine the elastic properties of the
cardiac extracellular matrix in health and disease. FS/17/61/33473 Dr M Bennett University Cambridge 1st intake 2017 – 4-year PhD Studentship £664,424
5 years BSc MBChB PhD of Cambridge (4th) Scheme: Ms Anna Francis; Ms Alice Sowton;
MA FRCP FAHA Ms Jennifer Leggat; Ms Robyn Macrae. 4 years
FS/17/58/33072 Dr L Heather University Lipids: dysregulated signalling molecules in the £628,379 FMedSci
BSc DPhil of Oxford type 2 diabetic heart? 5 years FS/17/62/33477 Prof M Bailey University Edinburgh 1st intake 2017 – 4-year PhD Studentship (4th) £624,376
BSc PhD FRSB of Edinburgh Scheme: Ms Viktoria Balogh; Ms Loes Elemans; Ms Iris
FS/18/3/33292 Dr A Lewandowski University Cardiac remodelling in preterm-born offspring: £658,359 Prunonosa-Cervera; Mr Benjamin Thomas. 4 years
BSc DPhil of Oxford defining the importance of early postnatal changes
and potential for neonatal dietary interventions to FS/17/63/33485 Prof R Touyz University Glasgow 1st intake 2017 – 4-year PhD Studentship £607,316
reduce long-term risk. 5 years BSc MBBCh MSc of Glasgow (4th) Scheme: Mr Simon Fisher; Ms Erin Higgins; Ms
PhD FMedSci Alice Main; Ms Kayley Scott. 4 years
FS/18/2/33221 Dr J Serbanovic University Role of the mechanoreceptor Pkd1 in endothelial £389,932
Canic of Sheffield dysfunction and atherosclerosis. 5 years
PhD8 British Heart Foundation Research Grant Awards 2017/18 Fellowships 9
4-year PhD Studentships (continued) PhD Studentships (continued)
FS/17/66/33480 Prof P Stewart University Leeds 1st intake 2017 – 4-year PhD Studentship (4th) £611,348 FS/17/76/33286 Mr M Hudda St George's, Improving assessments of body fatness, overweight £94,199
MD FRCP FMedSci of Leeds Scheme: Mrs Yilizila Abudushalamu; Mr Michael Bell; BSc MSc PhD University of and obesity in UK children and adolescents of
Ms Holly Foster; Ms Heba Shawer. 4 years London different ethnic origins. 3 years
FS/17/67/33483 Dr E Cartwright University Manchester 1st intake 2017 – 4-year PhD Studentship £607,876 FS/17/28/32807 Ms C Lewis University Inhibiting angiogenesis in aortic valves via S1P £107,465
BSc Msc PhD of Manchester (4th) Scheme: Ms Abimbola Akerele; Ms Cali BSc of Aberdeen receptors: a new therapeutic target. 3 years
Anderson; Mr Ryan Potter; Ms Katie Ryding. 4 years
FS/17/29/32828 Mr P Harrison University Measurement of preplatelets in inherited and £107,497
FS/17/68/33478 Prof D Greaves University Oxford 1st intake 2017 – 4-year PhD Studentship £659,464 BSc PhD FRCPath of Birmingham acquired thrombocytopenia. 3 years
BSc PhD of Oxford (4th) Scheme: Ms Lucija Fleisinger; Mr Oliver
Neely; Ms Helen Potts; Ms Agata Rumianek. 4 years
FS/18/9/33388 Miss C Koo University Identifying the tetraspanin/ADAM10 ‘molecular £120,670
BSc MSc of Birmingham scissor’ for the platelet collagen and fibrin receptor
PhD Studentships GPVI. 3 years
Reference number Name Institution Grant title Total
FS/18/11/33443 Miss R Stapley University Investigating the role of SLFN14 in megakaryocyte £150,698
BSc of Birmingham and platelet biology. 3 years
FS/17/75/33257 Miss Y Chan Cardiff University Investigation of the anti-atherogenic actions of £107,553
BSc (+)-catechin in vivo. 3 years
FS/17/38/32935 Miss Z Adams University Sex differences in the role of sympathetic nerve £107,372
BSc of Bristol activity in the development of hypertension in
FS/17/41/32976 Mr W Bonneuil Imperial College Chemokine transport dynamics and vascular disease. £115,303
humans. 3 years
London 3 years
FS/17/46/33121 Miss L Reolizo University Exploiting the inhibition of vascular smooth muscle £107,340
FS/17/73/33186 Miss A Francis Imperial College The effect of oestrogen on the function and local £130,822
BSc of Bristol cell proliferation and intimal thickening by PRH/
BSc London environment of the L-type Ca2+ channel. 3 years
HHEX. 3 years
FS/17/74/33192 Ms E Pchenlintseva Imperial College Acoustic patterning for next-generation drug £115,558
FS/17/42/32978 Ms A Rioja University Mechanisms of neovascularisation: signalling from £107,413
BSc London screening and cardiac engineering. 3 years
BSc MSc of Bristol VEGFR1 to the cytoskeleton through RhoA. 3 years
FS/17/39/32938 Miss Q Toe Imperial College Endothelial cell uptake of decompartmentalised £118,928
FS/18/7/33697 Student to University Joint NC3Rs/BHF PhD Studentship: Recreating £90,000
BSc London iron species in Eisenmenger syndrome: implications
be appointed of Cambridge thrombosis models using tissue-engineered arterial
for disease pathogenesis and treatment. 3 years
(Supervisor: Dr A constructs: a novel method to reduce and replace
Harper) mice used in platelet research. 3 years
FS/17/71/32953 Miss K Dalrymple King's College The influence of a complex intervention of diet and £112,228
London physical activity in obese pregnant women on the
FS/17/32/32916 Mr S Ahmed University Does enhanced smooth muscle cell contraction £105,522
cardiometabolic phenotype of 3 year old children:
BSc of East Anglia increase local matrix stiffness and promote smooth
analysis of the UPBEAT trial. 3 years
muscle cell proliferation? 3 years
FS/17/44/33022 Miss A Wright Lancaster Unravelling the mechanisms of apolipoprotein and £106,353
FS/17/27/32698 Miss R Sanders University Assessing the regulation and function of long non- £107,498
MSci University serum amyloid A aggregation in atherosclerosis.
BSc MRes MPhil of Edinburgh coding RNA LINC00961 in vascular endothelial cell
3 years
function. 3 years
FS/18/8/33698 Student to be Manchester Joint NC3Rs/BHF PhD Studentship: Development £90,000
FS/18/10/33413 Ms F Vacante University The functional consequence of miR-143HG loss on £67,715
appointed Metropolitan of E-Sense: a flexible in vitro platform to determine
BSc MSc of Edinburgh the development of atherosclerosis. 1 year, 9 months
(Supervisor: Dr S University cardiovascular risk. 3 years
White)
FS/17/43/33003 Miss K Miteva University The role of Ca2+ signalling in the regulation £107,808
of Leeds of Weibel-Palade Body trafficking and cargo
FS/17/72/33181 Miss A Bishop St George's, Stanniocalcin-1 and vascular remodelling at the £115,919
secretion. 3 years
BSc University maternal / fetal interface. 3 years
of London
FS/17/30/32832 Mr B Roper University Targeting the LOX-1 (SR-E1) scavenger receptor £107,879
MBiolSci of Leeds and atherosclerosis using synthetic proteins called
FS/17/40/32942 Ms S St George's, Investigations into calcium-sensing receptor £130,820
Affimers. 3 years
Carlton-Carew University mechanisms in the vasculature. 3 years
BSc of London
FS/17/45/33102 Miss R Dinsdale University Understanding the molecular pharmacology of £114,803
of Oxford vascular calcium-activated chloride channels.
3 years10 British Heart Foundation Research Grant Awards 2017/18 Clinical Fellowships 11
PhD Studentships (continued) Clinical Research Training Fellowships (continued)
FS/17/31/32848 Ms G Little University Study of the molecular mechanisms that allow the £116,868 FS/17/82/33322 Dr R Hughes University College The extended spectrum of apical hypertrophic £225,735
BSc of Reading collagen-binding chaperone protein HSP47 to London cardiomyopathy. 3 years
modulate platelet responses to collagen. 3 years
FS/17/34/32901 Dr K Knott University College Perfusion mapping in ischaemic heart disease. £206,139
FS/18/6/33696 Student to be University Joint NC3Rs/BHF PhD Studentship: Using £90,000 MA MBBS MRCP London 3 years
appointed of Sheffield zebrafish embryos to identify genes that protect
(Supervisor: Prof against atherosclerosis. 3 years
FS/18/18/33522 Dr T Hinton University Investigating the role of the carotid body in young £116,203
P Evans)
BMedSci MBChB of Bristol onset hypertension. 2 years
MRCP
FS/17/33/32931 Mr R Johnson University of Surrey Investigating arrhythmogenic risk from cardiac £107,854
BSc MBiol cell therapy; scrutinising the effects of human
myofibroblasts on iPSC-derived cardiomyocyte FS/17/49/32917 Dr K Hope University Comparing the mechanistic role of carotid bodies £220,320
function. 3 years BM BS BMedSci of Bristol in human heart failure with and without preserved
MSc FRCA ejection fraction. 3 years
Clinical Fellowships
FS/17/51/33096 Dr J Andrews University Early clinical development of a thrombus £168,504
MBChB of Edinburgh 18
F-radiotracer. 3 years
Intermediate Clinical Research Fellowships MRCP
Reference number Name Institution Grant title Total
FS/18/21/33447 Dr M Fontana University College The pathophysiology of cardiac AL amyloidosis: £717,044 FS/17/79/33226 Dr M Doris University Combined positron emission tomography and £120,628
PhD London phenotypic spectrum and clinical significance. MBChB of Edinburgh magnetic resonance imaging of coronary
5 years atherothrombosis. 1 year
FS/18/12/33270 Dr M Bailey University Vascular smooth muscle cell Orai1 in abdominal £515,929 FS/17/50/33061 Mr J Kaczynski University F-fluoride positron emission tomography-
18
£293,665
BSc PhD MB ChB of Leeds aortic aneurysm. 5 years of Edinburgh magnetic resonance imaging in patients with acute
PG Cert (Health neurovascular syndrome. 2 years
Research) MRCS
FS/18/22/33479 Dr A Jones University Reversibility of early cardiometabolic dysfunction in £763,253 FS/18/25/33454 Dr K Lee University High-sensitivity cardiac troponin I and risk £263,693
BSc BM PhD of Oxford sedentary and obese adolescents. 5 years MBChB MRCP of Edinburgh stratification of patients with suspected acute
coronary syndrome. 3 years
FS/18/23/33512 Dr M Holmes University Drug target validation and risk prediction for £1,026,833
BSc MBBS MRCP of Oxford coronary heart disease using targeted FS/17/53/33119 Dr T Moullaali University Does blood pressure variability (BPV) affect £168,553
MSc PhD blood-based metabolomics and proteomics. MBBS of Edinburgh outcome after stroke due to intracerebral
5 years haemorrhage?. 3 years
FS/18/13/33281 Dr R Thompson University The role of double-stranded RNA in pulmonary £722,505 FS/18/14/33330 Dr A Jackson University The epidemiology of peripartum cardiomyopathy £186,095
BMedSci MB ChB of Sheffield vascular remodelling. 4 years BSc MBChB of Glasgow in a Western European country: an analysis of the
MRCP (UK) PhD Scottish population 1990-2016. 3 years
FS/17/78/33180 Dr T Slater University Examining the effect of increasing endothelial cell £196,816
MMBS MRCP of Leeds insulin like growth factor-1 receptor expression in the
Clinical Research Training Fellowships endothelium on blood pressure homeostasis and
Reference number Name Institution Grant title Total endothelial cell function in health and diet induced
type 2 diabetes mellitus. 3 years
FS/18/15/33518 Dr J Kelly King's College The role of inflammation in the development of £144,900
BSc MBChB London spinal cord ischaemia after thoracoabdominal
MRCS aneurysm repair. 2 years FS/18/26/33501 Dr L Athithan University Cardiac rest and stress metabolism in patients with £136,122
MBBCh MRCP of Leicester type 2 diabetes. 2 years, 6 months
FS/17/77/33128 Dr F Papalia King's College Iron status and cardiac mechano-energetics in £226,286
BMedSci MBBS London heart failure. 3 years FS/17/54/33126 Mr N Denham University An experimental study regarding the effectiveness £238 301
BMBM of Manchester of PDE5 inhibition to prevent atrial fibrillation.
3 years
FS/18/16/33396 Dr M Ryan King's College Evaluation of a novel physiological biomarker of £245,683
BSc MBChB MRCP London hibernation in ischaemic left ventricular dysfunction.
3 years FS/17/47/32805 Dr J Lagan University Why is COPD associated with heart failure? £126,854
MA MRCP AFHEA of Manchester 2 years
FS/17/81/33318 Dr Z Raisi Queen Mary, Broken bones and broken hearts: relationships £231,716
Estabragh University of between osteoporosis and cardiovascular structure
London and function in UK Biobank. 3 years12 British Heart Foundation Research Grant Awards 2017/18 Regenerative Medicine Centres / Infrastructure Grants / Special Project Grants 13
Clinical Research Training Fellowships (continued) Special Project Grants
FS/17/52/33113 Dr C Pius University of An experimental study on the impact of myocyte £271,190 Listed alphabetically by Institute
MBChB Manchester ultrastructural remodelling on cellular function and
arrhythmogenesis following an ischaemic episode. Reference Number Name Location Grant title Total
3 years
SP/18/6/33805 Dr S Niederer The Alan Turing The BHF-Turing Cardiovascular Data Science Awards £49,310
DPhil Institute and King's (First call): Quantifying functional co-variation in
FS/17/80/33317 Dr S Lockhart University Examining the direct vascular actions of the £200,411 College London calcium handling proteins in cardiac myocytes (joint
of Oxford glucagon-like peptide-1 analogue liraglutide in funding with The Alan Turing Institute). 1 year
obese patients with coronary atherosclerosis.
3 years
SP/18/7/33806 Dr W Astle The Alan Turing The BHF-Turing Cardiovascular Data Science Awards £47,362
MA MMath PhD Institute and (First call): Looking for cardiovascular risk factors
FS/18/17/33514 Dr S Monga University The effect of altering myocardial lipid content on £290,431 University of in blood smear images (joint funding with The Alan
MBChB MMed of Oxford cardiac physiology in patients with aortic stenosis. Cambridge Turing Institute). 1 year
MRCP DPhil 3 years
SP/18/5/33804 Dr A Butterworth The Alan Turing The BHF-Turing Cardiovascular Data Science £26,481
FS/17/48/32907 Dr W Watson University Altering substrate selection as a potential £253,679 BA PhD MSc Institute and Awards (First call): Flexible fine-mapping of multiple
BSc MBBChir PGCert of Oxford therapeutic target in heart failure. 3 years University of intermediate traits at cardiovascular disease loci
(MedEd) MRCP Cambridge (joint funding with The Alan Turing Institute). 1 year
SP/18/3/33801 Dr E Di Angelantonio The Alan Turing The BHF-Turing Cardiovascular Data Science Awards £54,848
MD PhD MSc Institute and (First call): Using machine learning for personalised
University of CVD risk management (joint funding with The Alan
Regenerative Medicine Centres Cambridge Turing Institute). 1 year
Reference number Name Institution Grant title Total
SP/18/2/33800 Prof N Mills The Alan Turing The BHF-Turing Cardiovascular Data Science Awards £80,529
RM/17/1/33377 Prof S Harding Imperial College BHF Centre of Regenerative Medicine (renewal) £2,500,000
MBChB BSc PhD Institute and (First call): Machine learning in myocardial infarction
BSc PhD London 4 years
FESC FRCP University of to improve risk prediction and inform treatment
Edinburgh decisions (joint funding with The Alan Turing Institute).
RM/17/3/33381 Prof A Baker University of BHF Centre of Regenerative Medicine (renewal) £2,500,000 1 year
BSc PhD Edinburgh 4 years
SP/18/4/33803 Dr A Doherty The Alan Turing The BHF-Turing Cardiovascular Data Science Awards £68,524
RM/17/2/33380 Prof P Riley University BHF Centre of Regenerative Medicine (renewal) £2,500,000 Institute and (First call): Unsupervised learning of physical activity
BSc PhD FMedSci of Oxford 4 years University of markers and their association with cardiovascular
Oxford disease (joint funding with The Alan Turing Institute).
1 year
SP/17/11/32885 Prof S Cook Imperial College Defining the genetics, biomarkers and outcomes £1,999,834
Infrastructure Grants PhD MRCP London for dilated cardiomyopathy: a prospective multi-
centre study (GO-DCM). 4 years
Reference number Name Institution Grant title Total
IG/17/2/32993 Prof S Nourshargh Queen Mary, Funds towards the purchase of a multiphoton £314,211 SP/17/10/33219 Prof M Mayr King's College ERA-CVD 'transnational research projects on £249,492
BSc PhD FMedSci University of confocal microscope. 1 year MD PhD London cardiovascular diseases': non-coding RNAs in
London cardiac macrophages and their role in heart failure.
3 years
IG/18/2/33544 Prof S Watson University of Funds towards six items of imaging equipment at £754,233
BSc PhD FMedSci Birmingham the Centre of Membrane Proteins and Receptors SP/18/1/33797 Health Data Medical Research Joint funding towards Health Data Research UK £2,000,000
(COMPARE) at the Universities of Birmingham and Research UK Council (HDRUK) awards. 5 years
Nottingham. 1 year
SP/17/9/33243 UK Prevention Medical Research Joint funding towards the National Prevention £3,000,000
IG/18/1/33458 Prof D Newby University of Funds to upgrade and expand a radiochemistry £700,000 Research Council Research Initiative. 3 years
BA BSc PhD BM DM Edinburgh facility to deliver current and future cardiovascular Partnership
DSc FRSE FESC FACC PET research. 2 years
FMedSci
SP/17/12/32960 Prof D Newby University of Duration of dual anti-platelet therapy in acute £630,845
BA BSc PhD BM Edinburgh coronary syndrome across Scotland: the DUAL-
IG/17/3/33201 Dr S Semple University of Funds to upgrade a BHF-funded 3T magnetic £393,225 DM DSc FRSE FESC ACS2 trial. 5 years
BSc PhD MSc Edinburgh resonance imaging scanner. 1 year FACC FMedSci14 British Heart Foundation Research Grant Awards 2017/18 Special Project Grants / Clinical Study Grants / Programme Grants 15
Special Project Grants (continued) Programme Grants (continued)
RG/17/16/33294 Prof P Eaton King's College Furthering our understanding of PKGIα in £999,700
SP/18/8/33620 Dr T Webb University of ERA-CVD 'transnational research projects on £249,829
BSc PhD London cardiovascular health and disease. 5 years
BSc MRes PhD Leicester cardiovascular diseases': druggable MI genes:
utilising myocardial infarction genes for better
treatment. 3 years RG/17/15/33106 Prof M Shattock King's College The Na/K ATPase in cardiovascular health £1,199,974
BSc PhD FRCP (Edin) London and disease. 4 years
SP/17/15/33490 Dr P Quinlan University of Joint funding with MRC: UKCRC Tissue Directory £75,000
Nottingham and Coordination Centre Phase II. 3 years RG/17/7/33217 Prof P Mortimer Medical Research Joint funding with MRC: Deep phenotyping to £750,000
MD FRCP Council improve understanding of causal mechanisms and
underlying gene mutations in primary lymphoedema
SP/17/16/33519 Prof K Channon University of The NIHR-BHF Cardiovascular Partnership. £112,705
and lymphatic malformations. 5 years
MD FRCP FMedSci Oxford 3 years
RG/17/5/32936 Dr S Sinha University New therapeutic strategies for Marfan and other £1,271,390
SP/17/13/33347 Prof R McManus University of Seventh Joint Stroke Association/BHF Grant: £1,109,564
BA MB BChir of Cambridge genetically-triggered aortic aneurysm syndromes.
MSc MA (Oxon) Oxford Towards An Integrated Self-Monitoring SolutIoN
MRCP PhD 5 years
PhD MBBS FRCGP for Stroke/TIA: TASMIN5S (Ninth call). 5 years
RG/17/8/32924 Prof D Giussani University Cardiovascular dysfunction in the hypoxic fetus: £1,311,663
SP/17/14/33355 Dr H Gallagher University of Joint funding with NIHR (Health Technology £750,000
MA PhD ScD of Cambridge intervention by mitochondria-targeted antioxidants.
MA MSc PhD FRCP Southampton Assessment (HTA) Programme): Aspirin To Target
FRCOG (Renewal). 5 years
Arterial events in Chronic Kidney disease – the
ATTACK trial. 7 years, 6 months
RG/17/12/33167 Prof S Ozanne University Insulin and hypoxia: key determinants in the £1,103,850
BSc Hons PhD of Cambridge programming of cardiovascular disease by
maternal obesity. 5 years
Clinical Study Grants RG/17/11/33042 Prof D Beech University Endothelial Piezo1 channel in whole body physical £1,383,429
Listed alphabetically by Institute BSc PhD FMedSci of Leeds activity and cardio-metabolic protection. 5 years
Reference Number Name Location Grant title Total RG/17/9/32812 Prof G Murphy University Towards the prevention of post cardiac surgery £1,399,996
BSc MBChB MD of Leicester organ failure. 5 years
CS/17/6/33361 Prof D Werring University College OPTIMAS: OPtimal TIMing of Anticoagulation £2,045,998
FRCS
BSc MBBS FRCP PhD London after AF-associated acute ischaemic Stroke:
a randomised controlled trial. 5 years
RG/18/2/33392 Prof M Boyett University of Control of ion channel expression in the cardiac £1,316,626
BSc PhD FRSB FRCP Manchester conduction system in disease: search for potential
CS/17/4/33009 Dr R Gardner University of How do arrhythmias and conduction disturbances £429,737
new therapeutic targets. (Renewal). 5 years
MBChB MD Glasgow contribute to death or rehospitalisation in patients
MRCP FESC discharged following an admission with acute heart
failure? A prospective, observational, multi-centre RG/18/1/33351 Prof S Bhattacharya University Precision therapeutics for cardiovascular £1,004,873
cohort study. 4 years, 6 months MBBS MD MRCP of Oxford inflammation. 5 years
MSc FESC FMedSci
CS/17/5/32826 Prof T Robinson University of Tenecteplase in Wake-up Ischaemic Stroke Trial £323,014
MD FRCP FESO Leicester (TWIST). 3 years RG/17/10/32859 Prof K Channon University Non-canonical roles for tetrahydrobiopterin in £1,399,658
AFHEA MD FRCP FMedSci of Oxford cardiovascular disease pathogenesis. 5 years
RG/17/14/33085 Prof D Paterson University Cyclic nucleotide coupled phosphodiesterase £617,619
Programme Grants MA MSc DPhil DSc
FRSB FPhysiol Hon
of Oxford signalling in cardiac sympathetic neurons in heart
disease: novel therapeutic targets. 3 years
Listed alphabetically by Institute FRSNZ
Reference number Name Institution Grant title Total RG/18/5/33532 Prof P Riley University Epicardial activation and signalling during £588,176
RG/18/3/33405 Dr J Crawley Imperial College Protein S-TFPI anticoagulant pathway: molecular £1,271,273 BSc PhD FMedSci of Oxford cardiovascular repair: comparing regenerative
BSc PhD London mechanisms and therapeutic potential. 5 years and non-regenerative models: programme
extension. (Renewal). 3 years
RG/17/13/33173 Prof J Gorelik Imperial College Function follows form: improving the failing heart by £1,081,461
MSc PhD London targeting signalling nanodomains in myocytes. 5 years RG/17/6/32944 Prof M Zaccolo University Topography, regulation and function of PDE- £1,226,593
MD of Oxford dependent cAMP nanodomains in cardiac myocytes.
(Renewal). 5 years
RG/18/4/33541 Prof J Mitchell Imperial College Understanding the COX-2/prostacyclin/NO axis £995,313
BSc PhD London in the cardiovascular system. 5 years16 British Heart Foundation Research Grant Awards 2017/18 New Horizons Grants / Translational Awards / Project Grants 17
New Horizons Grants Project Grants (continued)
PG/17/22/32868 Prof J Crawley Imperial College The role of VWF-dependent platelet ‘priming’ and £196,861
Reference number Name Institution Grant title Total
BSc PhD London neutrophil recruitment in DVT. 2 years
NH/18/1/33511 Dr V Muthurangu University College Towards comprehensive assessment of heart disease £291,881
BSc MD(Res) London in children using real-time cardiovascular magnetic
PG/18/17/33572 Dr J Crawley Imperial College The structural basis of ADAMTS13 allostery. £294,048
MRCPCH resonance. 2 years
BSc PhD London 2 years, 6 months
PG/18/19/33584 Dr R de Groot Imperial College ADAMTS7 and cardiovascular disease: identifying £180,799
BSc MSc PhD London molecular mechanisms. 2 years
Translational Awards
Listed alphabetically by Institute PG/17/81/33345 Dr J Keegan Imperial College Arrhythmia insensitive whole-heart late gadolinium £239,908
BSc MSc PhD London enhancement (LGE) MRI for assessment of native,
Reference number Name Institution Grant title Total surgical and post-ablation scar tissue in patients
with heart rhythm disturbance. 3 years
TG/16/2/32657 Prof P Chowienczyk King's College First-phase ejection fraction as a diagnostic £146,961
BSc MBBS FRCP London marker and therapeutic target in cardiac disease.
2 years PG/17/57/33130 Dr N Latif Imperial College Role of the mechanosensitive ion channel Piezo1 £126,567
BSc PhD London in human valve endothelial cells. 2 years
TG/16/1/32108 Dr P Lamata King's College Improving the identification of faulty valves. £245,076
PhD London 2 years PG/17/42/33039 Dr I Salles-Crawley Imperial College BAMBI and its role in the anticoagulant function of £97,016
BSc MSc PhD London the endothelium. 1 year
TG/16/3/32687 Dr G Gray University 11βHSD1 inhibition: a distinctive acute-MI £318,737
BSc PhD FBPhS of Edinburgh intervention for promotion of peri-infarct vascularisation, PG/17/61/33187 Prof C Terracciano Imperial College Mechanosensitive molecular mechanisms of £97,140
FRSB reduction of infarct expansion MD PhD London myocardial fibrosis: a multicellular approach.
and prevention of heart failure. 2 years 1 year, 6 months
TG/16/3/32687 Dr D Adlam University Development of a prototype pericardial left ventricular £249,771 PG/17/60/33168 Dr S Wort Imperial College The role of H3K27 methylation in vascular endothelial £193,282
BA BM BCh DPhil of Leicester assist device. 2 years MA (Oxon) MBBS London cell proliferation and function: implications for
FRCP FRCP PhD FFICM pulmonary arterial hypertension.
2 years
TG/16/3/32687 Dr L Ebah University Transdermal Fluid Removal (TFR): a novel community- £134,293
MD MRCP PhD of Manchester based and patient self-administered treatment for fluid PG/18/2/33446 Prof L Zhao Imperial College Investigation of selective HDAC6 inhibitor, C1A, as £164,885
overload in heart failure. MD PhD London a treatment for pulmonary arterial hypertension.
2 years 2 years
PG/17/38/33024 Dr S Chapple King's College Activation of Nrf2 antioxidant defences by £240,505
BSc PhD London sulforaphane confers vascular protection in
offspring exposed to a maternal obesogenic diet.
Project Grants 3 years
Listed alphabetically by Institute
PG/17/50/32903 Prof P Chowienczyk King's College Partitioning the determinants of pulse pressure into £275,269
Reference number Name Institution Grant title Total BSc MBBS FRCP London those due to ventricular ejection and characteristics
of the arterial tree. 3 years
PG/18/15/33566 Dr J Ahnstrom Imperial College Regulation of versican procoagulant role by ADAMTS- £223,603
BSc MSc PhD London mediated proteolysis. 3 years
PG/17/44/33064 Prof P Eaton King's College An investigation of the potential therapeutic effects £290,749
BSc PhD London of Sulforadex in Noonan syndrome. 3 years
PG/17/33/32990 Dr G Birdsey Imperial College VEGF-dependent angiogenesis requires activation of £130,472
BSc PhD London specific isoforms of the ETS transcription factor ERG.
1 year, 6 months PG/17/65/33215 Dr T Kampourakis King's College Cardiac thick filament modulators: a potential new £145,956
PhD Dipl London class of heart failure therapeutics. 1 year, 3 months
PG/18/3/33515 Dr A Bottle Imperial College Using large databases to describe the current £222,035
BSc (Hons) MSc London management of heart failure in England and model risk PG/17/37/33023 Dr A Kapustin King's College KLF4 regulates VSMC migration and proliferation £131,410
PhD trajectories to improve shared decision-making. 2 years, BSc PhD London via exosomes. 1 year, 6 months
6 months
PG/17/79/33313 Dr J Liu King's College Functional characterisation of the human £76,615
PG/17/71/33242 Dr J Boyle Imperial College Development of a fluorescent reporter probe for £213,438 AB PhD London congenital heart disease gene RAPGEF5. 1 year
BSc MBChB London enzyme-activity of heme oxygenase 1 (HO-1).
PhD FRCPath 2 years, 3 months18 British Heart Foundation Research Grant Awards 2017/18 Project Grants 19
Project Grants (continued) Project Grants (continued)
PG/17/53/33079 Prof G Lombardi King's College Targeting recipient antigen-presenting cells with sialic £269,742 PG/18/21/33599 Dr C Watson Queen's University Epigenetic changes in hypoxic cardiac fibroblasts: £153,454
BSc PhD London acid-modified alloantigen to promote transplantation BSc PhD PGDip Belfast implications for DNA methylation in the pathogenesis
tolerance. 3 years UT&L of ischaemic heart disease. 2 years
PG/17/48/32956 Prof M Mayr King's College AortOMICS: proteomics-based assessment of thoracic £238,948 PG/18/10/33550 Dr R Bell University College Sodium / glucose transporters in the heart and their £283,777
MD PhD London aneurysm formation. 3 years BSc PhD MBBS London role in hyperglycaemic exacerbation of ischaemia /
MRCP reperfusion injury following acute myocardial infarction.
3 years
PG/18/6/33530 Dr M Pfuhl King's College Dissecting the activation mechanism of titin kinase by £278,787
PhD London NMR spectroscopy. 3 years
PG/17/88/33401 Dr K Brown University College Using National Congenital Heart Diseases Audit data £289,840
BA MB BChir London to explore the impact of non-medical risk factors on
PG/17/51/32950 Dr M Robson King's College Novel pathways involving ANCA and monocytes in £292,415
MRCP MSC MD late post-operative outcomes for children with complex
MRCP PhD London ANCA vasculitis. 3 years
congenital heart defects. 3 years
PG/17/52/33059 Dr W Wong King's College Prolonging cardiac allograft survival by targeting £246,748
PG/17/90/33415 Prof A Hughes University College Cardiovascular mechanisms linked to cerebral amyloid £273,844
BSc MBBS MRCP London the indirect antigen presentation pathway with an
BSc MBBS PhD London β deposition and cognitive decline: a sub study of
DPhil immunotoxin. 2 years
INSIGHT 46. 2 years, 6 months
PG/17/39/33027 Dr M Zhang King's College The modulation of cAMP/PKA signalling by cardiac £232,715
PG/17/47/32963 Dr V Muthurangu University College Harnessing the potential of magnetic resonance £211,432
MD PhD London NOX2. 3 years
BSc MD (Res) London augmented cardiopulmonary exercise testing (MR-
MRCPCH CPET) in pulmonary arterial hypertension. 3 years
PG/17/67/33218 Dr S White Manchester Defining the mechanisms of normal and pathological £234,445
BSc DPhil Metropolitan force sensing by endothelial cell adhesion complexes.
PG/17/70/33232 Prof C Ruhrberg University College VEGF signalling pathways in vascular permeability. £120,360
University 3 years
PhD London 1 year
PG/17/36/33021 Prof R Corder Queen Mary, Identification of the constitutive, secretory-pathway, £132,151
PG/18/22/33604 Dr K Sutcliffe University College Children’s and parents’ informed and willing consent £112,707
BSc MSc PhD University of endothelin-converting enzyme. 2 years
BA MSc PhD London to heart surgery. 1 year, 6 months
MRPharmS London
PG/17/20/32864 Prof I Zachary University College Role of Bcar1/p130Cas in heart development. £245,846
PG/17/82/33368 Dr L Green Queen Mary, A pragmatic pilot randomised control trial of £170,929
BSc PhD London 3 years
MBBS MSc (HRM) University of prothrombin complex concentrates versus fresh frozen
MD (Res) FRCP London plasma in adult patients who are undergoing heart
FRCPath surgery (PROPHESY). 2 years, 3 months PG/17/87/33400 Prof I Zachary University College Investigation of the role of Bcar1/p130Cas in £187,454
BSc PhD London atherosclerosis. 2 years
PG/17/74/33111 Prof A Hobbs Queen Mary, Defining a pivotal role for endothelium-derived C-type £245,430
BSc PhD University natriuretic peptide in angiogenesis and vascular PG/17/64/33205 Dr D Dawson University A randomised, double-blind placebo controlled £299,169
of London remodelling. 3 years DM FRCP DPhil of Aberdeen trial to test if a beneficial effect of beta-blockers on
FESC exacerbations of chronic obstructive pulmonary disease
(COPD) is restricted to those patients with occult
PG/17/85/33395 Prof S Nourshargh Queen Mary, Impact of mast cells on neutrophil-pericyte interactions £238,442
heart disease. 3 years
BSc PhD FMedSci University and neutrophil effector functions: role of IL-17A?. 3 years
of London
PG/17/30/32961 Prof Dr P Kirchhof University Impact of chronic intermittent hypoxia on atrial resting £203,196
MD FESC FRCP of Birmingham membrane potential and NaV1.5 channel function:
PG/17/41/33038 Dr D Przulj Queen Mary, Time-restricted eating as a weight loss intervention in £61,574
(Edin) a new mechanism for causing atrial fibrillation. 3 years
PhD University obese adults: a pilot study. 1 year
of London
PG/17/55/33087 Dr D Pavlovic University Cardiotonic steroids in patients with atrial fibrillation £172,818
BSc DPhil FHEA of Birmingham and heart failure: quantification, functional effects
PG/17/59/33139 Prof A Tinker Queen Mary, Ric8b: a modulator of heterotrimeric G-protein £143,054
and personalisation of digoxin therapy. 2 years
BA MB BS FRCP University signalling and its role in cardiovascular physiology.
PhD FMedSci of London 2 years
PG/17/34/32996 Dr M Bond University Nuclear action dynamics and vascular cell behaviour. £190,161
BSc PhD of Bristol 3 years
PG/17/40/33028 Prof T Warner Queen Mary, Re-evaluating the effects of aspirin on the £239,026
BSc PhD University cardiovascular system. 3 years
of London PG/17/66/33216 Prof S George University Attenuation of intimal thickening via porcupine £140,074
BSc PhD of Bristol inhibition. 3 years
PG/17/91/33428 Dr C Watson Queen's University Investigating the role of tetranectin in cardiac £242,517
BSc PhD PGDip Belfast remodelling and its utility as a heart failure biomarker.
UT&L 3 years20 British Heart Foundation Research Grant Awards 2017/18 Project Grants 21
Project Grants (continued) Project Grants (continued)
PG/17/89/33414 Prof J Hancox University Drug-induced hERG potassium channel inhibition: £207,792 PG/17/63/33198 Dr M Reed University The IPED (Investigation of Palpitations in the £21,347
BSc PhD FRSB of Bristol novel access and binding determinants? 3 years MA MB BChir of Edinburgh Emergency Department) study: randomised controlled
FBPhS MRCS FCEM MD trial of the use of a smart phone based event recorder
versus standard care for patients presenting to
the emergency department with palpitations and
PG/17/75/33095 Prof P Madeddu University Investigation of a novel proangiogenic mechanism £148,688
pre-syncope. 1 year
MD of Bristol centred on miR-532, BACH1, angiopoietin-1 and
Notch/Dll4 in human pericytes. 2 years
PG/17/83/33370 Dr A Tavares University Novel imaging biomarker for detection of regional £276,970
BSc MSc PhD of Edinburgh cardiovascular inflammation using positron emission
PG/17/62/33190 Prof S Mundell University Regulation of P2Y12 receptor expression and activity £202,332
tomography (PET). 2 years, 6 months
BSc PhD of Bristol by inhibitory pathways in human platelets: a novel
mode of action of antiplatelet drugs? 3 years
PG/17/54/32981 Dr S Vermeren University Dual function of the GTPase-activating protein ARAP3 £237,663
(née Krugmann) of Edinburgh in the regulation of endothelial permeability. 3 years
PG/18/8/33540 Dr A Teschemacher University Development of a strategy to limit lactate-mediated £117,734
MSc PhD
MSc PhD of Bristol sympathoexcitation. 1 year, 8 months
PG/17/21/32844 Prof T Frayling University The genetics of favourable adiposity. 3 years £234,607
BSc PhD of Exeter
PG/18/14/33562 Prof M Bennett University Development of 3D finite element analysis and £246,185
BSc MBChB PhD of Cambridge imaging to predict human atherosclerotic plaque
MA FRCP FAHA instability. 3 years PG/17/26/32881 Prof G Baillie University Targeting PDE3/4 to allow regulation of cardiac £117,375
FMedSci BSc PhD of Glasgow calcium homeostasis in disease. 2 years
PG/17/45/33071 Dr M Harper University The role of the mitochondrial permeability transition £164,274 PG/17/25/32884 Prof C Berry University CORonary MICrovascular Angina (CorMicA): a £297,478
MA PhD of Cambridge pore in procoagulant platelets. 2 years BSc MB ChB PhD of Glasgow mechanistic pilot trial and nested MRI sub-study.
FRCP (Gla) FRCP 3 years
(Edin) FACC FESC
PG/17/58/33134 Dr W Li University Role of BMP9 in protecting pulmonary vascular £136,266
BSc PhD of Cambridge integrity: implication in sepsis and acute respiratory
distress syndrome (ARDS). 2 years PG/18/9/33548 Dr C Loughrey University Investigating the therapeutic potential of RUNX1 £285,403
BVMS PhD FHEA of Glasgow for myocardial infarction. 3 years
MRCVS
PG/17/69/33229 Dr X Li University Investigating the role of PLK1 in regulating £182,399
MD PhD of Cambridge inflammation. 2 years
PG/17/23/32850 Prof J McMurray University The effects of sacubitril / valsartan compared £292,604
BSc MB ChB MD of Glasgow to valsartan on left ventricular remodelling in patients
PG/18/20/33595 Prof Z Mallat University Regulatory pathways that control Type-2 innate £284,752
FRCP FESC FACC with asymptomatic left ventricular systolic dysfunction
MD PhD of Cambridge lymphoid cells in atherosclerotic and ischaemic
FAHA FRSE after myocardial infarction: a randomised, double-
heart disease. 3 years
blinded active-comparator cardiac-MR based trial.
2 years
PG/17/73/33251 Dr M Nus University Targeting marginal zone B cells to protect against £292,736
BSc PhD of Cambridge atherosclerosis. 3 years
PG/18/13/33558 Prof T Quinn University Use and impact of the pre-hospital 12-lead £196,500
MPhil RN FRCN of Kingston electrocardiogram in the primary PCI era: mixed
PG/17/80/33343 Dr K University The role of dietary potassium in regulating salt £166,513 FESC FAHA FACC method study (PHECG-2) 1 year, 6 months
O'Shaughnessy of Cambridge transport across the DCT in the kidney. 2 years
MA BM BCh DPhil
PG/17/84/33372 Dr S Calaghan University The caveolar coat complex as a mediator of £128,308
FRCP FHEA
BSc PhD of Leeds mechano-sensation in the heart 2 years
PG/17/24/32886 Dr S Sinha University Heterogeneity of the human epicardium: molecular £183,375
PG/17/72/33255 Dr A Maqbool University Attenuating cardiac inflammation and remodelling £270,111
BA MB BChir of Cambridge determinants and functional consequences.
BSc PhD of Leeds by targeting the Tenascin C - TLR4 axis. 3 years
MRCP PhD 2 years
PG/17/27/32928 Dr R Pease University Identifying the origin of plasma FXIII-A and defining £268,898
PG/17/46/32880 Dr S Robinson University Deciphering the angiogenic tug-of-war between £182,222
BA PhD of Leeds the roles of cellular FXIII-A. 3 years
PhD of East Anglia neuropilin-1 interacting integrins: phase II. 2 years
PG/17/28/32943 Prof J Schneider University Cardiac microstructure beyond diffusion tensor £185,541
PG/18/26/33589 Dr V MacRae University How does NPP1 ablation drive arterial £176,162
Dipl Phys PhD of Leeds imaging. 3 years
BSc PhD of Edinburgh calcification? 2 years22 British Heart Foundation Research Grant Awards 2017/18 Project Grants 23
Project Grants (continued) Project Grants (continued)
PG/17/43/33041 Dr C Stover University C5L2: regulator of fatty liver disease? 2 years £60,707 PG/18/4/33521 Dr R Burton University Elucidating the interactions between IP3-dependent £202,761
MD PhD of Leicester BSc MSc MBA of Oxford Ca2+ release and Ca2+ stimulated adenylyl cyclases in
DPhil FRSA controlling atrial function. 3 years
PG/17/86/33399 Prof S Allan University The VWF/ADAMTS13 axis as a potential therapeutic £168,819
BSc PhD of Manchester target in the treatment of thrombo-inflammation in PG/18/11/33552 Prof K Dora University The role of aquaporins in determining the water barrier £128,045
stroke. 2 years, 4 months BSc PhD MA of Oxford in coronary arteries. 1 years, 6 months
PG/17/29/32945 Prof M Boyett University Why does heart block occur at night (especially £212,171 PG/17/68/33247 Dr J Hartmann- University Systematic review of weight regain after intentional £142,943
BSc PhD FRSB of Manchester in athletes)? 3 years Boyce of Oxford weight loss and its impact on cardiovascular and other
FRCP DPhil MA BA related health outcomes. 2 years
PG/18/12/33555 Prof K Brennan University PKCα: a potential new therapeutic target for £175,314 PG/18/1/33430 Prof C Monaco University Role of IRF5 in the function of CD11c+ macrophages £259,681
BA MA PhD of Manchester cardiovascular disease. 2 years MD PhD of Oxford in atherosclerosis. 2 years
PG/18/24/33608 Dr K Dibb University Understanding the structural and functional properties £226,543 PG/18/16/33570 Dr C Reith University Cholesterol Treatment Trialists' (CTT) Collaboration: £174,204
BSc PhD of Manchester of atrial Ca2+ release sites, how they are remodelled in BSc MBChB of Oxford meta-analyses of individual participant adverse
heart failure and the consequences for atrial function FRCP (Gla) FFPM event data from randomised controlled trials of statin
and arrhythmias. 3 years therapy. 2 years
PG/17/32/32987 Dr H Dobrzynski University Detailed 3D modelling of human cardiac anatomy £118,243 PG/17/49/33099 Dr M Trivella University Systematic reviews on the prognostic role of £129,967
BSc PhD of Manchester with emphasis on the conduction system using micro- BSc MSc DPhil of Oxford biomarkers in heart failure. 2 years
computer tomography and mathematical modelling
techniques: variation with ageing and heart failure.
PG/18/18/33574 Dr E Tzima University PECAM as a novel regulator of cardiac function. £272,121
2 years
PhD of Oxford 3 years
PG/18/5/33527 Dr G Galli University Maladaptive cardiac remodelling in adult £247,233
PG/17/76/33082 Prof J Gibbins University Connexins as regulators of platelet function: £245,653
BSc PhD of Manchester offspring from hypoxic pregnancies: role of
BSc PhD of Reading investigation of the mechanisms of action in the
cellular calcium homeostasis. 3 years
control of haemostasis and thrombosis. 3 years
PG/18/7/33535 Dr A Greenstein University Junctophilin 2 as a cytoskeletal anchor facilitating £214,963
PG/17/56/33115 Prof P Evans University Role of endothelial STAT5A in focal vascular £226,798
BSc MBChB of Manchester vascular smooth muscle cell ion channel cross-talk.
BSc MSc PhD of Sheffield inflammation and atherosclerosis. 3 years
MRCP PhD 3 years
PG/18/23/33605 Dr A Lawrie University Investigating the sex-dependent role of £158,377
PG/17/78/33304 Dr D Oceandy University Targeting the Hippo pathway to enhance the £221,780
BSc PhD of Sheffield macrophage subtypes in the development
MBChB PhD of Manchester regenerative capacity of iPS-derived cardiomyocyte.
of pulmonary arterial hypertension. 2 years
3 years
PG/17/77/33125 Dr H Shiels University Cardiotoxicity of polycyclic aromatic hydrocarbons £297,549
BSc MSc PhD of Manchester (PAHs). 3 years
PG/17/35/33001 Prof M University Translating signals from genome-wide association £298,431
Tomaszewski of Manchester studies into biological mechanisms of hypertension –
MD FAHA FRCP expression quantitative trait locus analysis in the human
kidney. 2 years, 6 months
PG/17/31/32988 Dr X Wang University Investigating prolylcarboxypeptidase (PRCP) cascade in £266,843
MB ChB PhD of Manchester attenuating oxidative stress and mitochondrial damage:
is PRCP a suitable target for treating heart failure?
3 years
PG/18/25/33587 Prof I Spyridopoulos University Role of CX3CR1 and T-lymphocytes in myocardial £158,765
MD of Newcastle ischaemia / reperfusion injury. 2 years
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