For Organ Transplantation - 19th Congress of the European Society - #ESOT2019 Advanced Programme
←
→
Page content transcription
If your browser does not render page correctly, please read the page content below
19th Congress of the European Society
for Organ Transplantation
September 15 - 18, 2019
Copenhagen, Denmark
#ESOT2019 Advanced Programme
ECTORS
European
— #ESOT2019 — 1
Cell Therapy and
organ regeneration
Section
FIVE PILLARS OF THE ESOT 2019 CONGRESS
TEN Reasons to Attend
1 Be inspired 7 Explore how to manage career development
2 Drive progress 8 Attend dedicated tracks to maximise the learning
3 Explore the edge of our current practice and experience
achievements 9 Share your research and be selected for focused
4 Discuss with experts and innovative thinkers about discussions – guided and instructed by key opinion
Why vs Why Not? leaders in the field
5 Interact with peers and pave the way forward 10 Get engaged in this interactive meeting and take an
together active role in shaping the future of transplantation
research and clinical practice
6 Master the latest trends of basic and translational
science
Who should attend?
The target audience for this conference includes all fields involved in health care and research with an affiliation in
transplantation. This includes but is not limited to:
¢ Transplant surgeons ¢ Transplant scientists
¢ Physicians of all fields with an involvement in ¢ Nutrition and rehabilitation specialists and
transplantation coordinators
¢ Coordinators, Nurses ¢ Transplant pharmacists
¢ General surgeons and clinicians with an interest in ¢ Perfusionists
transplantation
Further, health care professionals with an involvement in treatment of organ failure, cell therapy, tissue and
regenerative medicine are warmly welcome to our conference.
2 — #ESOT2019 —
Dear Colleagues, Dear Friends,
The 19th Congress of ESOT will take place in Copenhagen, the beautiful capital of Denmark. The ESOT 2019 Congress
will cover all areas of transplantation, both basic science and clinical aspects. Some of the major topics of the Con-
gress will be: from ancient legends to modern miracles, the importance of advances in molecular medicine for solid
organ transplantation, and tissue engineering. These, together with other hot topics from all areas of transplantation
will be presented in a program developed by world leading transplant physicians, surgeons and scientists.
Solid organ transplantation has a long history in Denmark. Kismeyer and Simonsen are among the real pioneers de-
veloping Transplant Immunology since the early sixties. Since then, all types of organ transplantation have evolved in
Denmark to high international standards. We are therefore delighted and honoured that ESOT selected Copenhagen
for its prestigious Congress. Copenhagen is an ideal congress city, known to be a safe, eco-friendly and bike friendly
capital city. It has extensive green areas and a harbor so clean that you can swim in it. Transportation from the modern
congress centre to the city is easy and short, so time can be spent efficiently. After an intense day at the Congress,
relaxation in cosy Copenhagen will be a delight. Get inspired by award winning new Nordic cuisine, the impressive
mixture of historic and modern Danish design and architecture, Royal Castles, see the Little Mermaid or take a tour
through the old canals.
On behalf of the Danish Transplantation Society and on behalf of the Congress Organizing Committee we warmly
welcome you to ESOT 2019 in Copenhagen.
Allan Rasmussen and Finn Gustafsson
Congress Chairs
Dear Colleagues, Dear Friends
We are truly delighted to cordially invite you to be Inspired and experience real Progress at the ESOT Congress in Co-
penhagen, a transplant meeting of truly great scientific substance delivered in great ESOT style!
The philosophy behind every ESOT Congress is that every two years we produce a totally New Congress in content and
format; ESOT 2019 Copenhagen not only follows this rule but aspires to be the best transplant congress ever! ESOT
2019 Copenhagen is designed to be Your Congress, tailoring and targeting its content to the discipline that you serve,
the stage of your career journey in transplantation and your professional aspirations.
Knowledge will be delivered through a plethora of networking opportunities leading to new collaborations so that the
end of the Congress will mark many new beginnings in transplantation. We aim to explore the edge of our current prac-
tice and achievements and also challenge each other about great things that have not yet happened, ask ourselves,
Why Not? And pave together the way forward.
Looking at the hot topics of the Congress (which are just the appetisers for a great feast…), we will learn from history
and each other, make patients active partners in our endeavours, vigorously debate our ethical conduct, take deep
dives in the waters of basic and translational science so that we can bring to the surface clinical solutions, admit the
moments we reached our clinical limits and explore how to push them further, debate and design innovation with
realism and all in the context of our palpable and substantial professional development. Furthermore, the ESOT award
winning Digital Congress Innovations have now reached new heights and they are designed to bring people together
(even if they are not physically at the Congress!), maximise their interaction and advance their knowledge. Last but
most certainly not least, all these are going to happen in Copenhagen, a dream city that can make those who adore
classic fairy tales and the enthusiasts of modern miracles equally happy and in the Bella Conference Centre that is
designed to make your time at the Congress Productive and Enjoyable. Join us in Copenhagen!
Be Inspired and Drive Progress!
Vassilios Papalois and Allan Rasmussen
Scientific Program Committee Chairs
— #ESOT2019 — 3
NEW at #ESOT2019
Find Out What’s New:
n Machine Perfusion and VAD Contest
n Organ Reconditioning
n Regenerative Medicine
n Stem cells and Gene Editing: a disruptive wedding
n ‘Omics’ technologies in Transplantation
n The unthinkable donors and recipients
n The Patient definition
n Cross-specialty learning
n Empowered transplanters can get to the TOP
n How to navigate the environment of Regulatory authorities and Bodies
And much more on the Format:
Campfires
The chance to interact with the speaker and your peers in small group sessions based on informal
discussion.
Hot topic tables
Take advantage of valuable peer-to-peer learning with small, moderated discussions with your
peers on topics relevant to you.
Education Track
Absorb the vision and expertise of Big Players at classroom-style learning sessions
The Buddy System
Connect “First time” ESOT Congress participants with experienced attendees.
Arenas
Debating cutting edge topics
4 — #ESOT2019 —
Table of content
6 Programme Overview 14 Refresher
8 Committees 16 Speciality Update Symposia
10 Legenda 19 Scientific programme
12 Plenary sessions 43 ESOT 2019 Congress Awards
12 State of the Art Sessions 44 Registration
13 Inspire & Drive Sessions 45 Copenhagen informations
13 Education Tracks 45 Venue
14 MDT Sessions 46 Partners
— #ESOT2019 — 5Scientific Programme Overview saturday,
September 14
UEMS/ESOT
EXAMS
Sunday, September 15
Specialty UPDATE SymposiA
9:00
12:50 EDTCO ECTTA ELITA EPITA EKITA YPT BSC VCA ECTORS ETAHP ELPAT
13:30 Edu Track 1 MDT 1 Elevator EP 01 RefResher 1 Focus GroupS Moderated MP 01 Brief Oral BOS 01
14:30 Immunology It’s all about Pitch Translational Science FG 01 - FG 05 E-Poster MP 04 Sessions BOS 05
14:30 ABCs and safety
15:00 beyond
Special session BANFF meets MDT 2
Corporate Corporate Joint
15:10 Antibody mediated rejection EKITA: The great ECMO EU TRAIN
Parallel Parallel Session
16:40 and complement. Brothers in from histology challenge! CALLING
Symposium Symposium ESOT-IPTA
arms? to bedside (Joint EDTCO/ECTTA/BSC)
17:00 Plenary 1
19:00 Be Inspired, be Driven
19:00
Networking Cocktail
20:00
Monday, September 16
7:30 Edu Track 2
8:00 Tolerance is here to stay
8:00 Full Oral Sessions Brief Oral Sessions
9:00 OS 01 - OS 06 BOS 06 - BOS 07
SOTA 1 SOTA 2 SOTA 3
9:10 Microbiome in transplantation: Organ allocation algorithm How to choose the right research model
10:40 friend or foe?
10:40
Break
11:10
11:10 INSPIRE & DRIVE 1 transplant refResher 2 Full Oral Focus
11:40 research Sessions GroupS
How to get to the top Learning from neighbouring
11:40 corporate (Hands-on) Challenge OS 07 - OS 12 FG 06 - FG 10
12:40 Workshop specialities
Corporate Corporate Corporate YPT
13:00 MODERATED E-POSTER ESOT ViP Brief Oral Sessions
Parallel Parallel Parallel Future Leaders
14:00 MP 05 - MP 08 VIP 01 BOS 08 BOS 10
Symposium Symposium Symposium on Stage
14:05 Plenary 2
15:35 Single cells omics: generating an atlas to chart transplant organs
15:35
Break
16:00
16:00 INSPIRE & DRIVE 2 Edu Track 3
corporate Full Oral brief Oral Elevator
16:30 Evidence based practice is killing Xenotransplantation, (Hands-on) Sessions Sessions Pitch
16:30 the art of medicine soon a reality? Workshop OS 13 - OS 18 BOS 11 - BOS 13 EP 02
17:00
17:00
17:30 refResher 3 corporate Full Oral brief Oral
(Hands-on) Sessions Sessions ESOT
17:30 Big Data
Workshop OS 19 - OS 24 BOS 14 - BOS 16
General
18:00
Assembly
18:05
18:30
Corporate Plenary SymposiUM
18:30
19:35Tuesday, September 17
7:30 Edu Track 4
8:00 Machine perfusion
8:00 goes prime time Full Oral Sessions Brief Oral Sessions
9:00 OS 25 - OS 30 BOS 17 - BOS 19
SOTA 4 SOTA 5 SOTA 6
9:10 DCD: push the boundaries Small Patients, Big Challenges
Pluripotent Stem Cells Meet Genome
10:40
Editing: a disruptive wedding
10:40
Break
11:10
11:10 INSPIRE & DRIVE 3 refresher 4 corpORATE Focus Elevator
11:40 Full Oral (Hands-on)
Relight my fire Inflammation Workshop Groups Pitch
Sessions corpORATE
11:40 (Hands-on)
FG 11 - FG 15 EP 03
OS 31 - OS 36
12:40 Workshop
Corporate Corporate Corporate Moderated
13:00 ESOT ViP Brief Oral Sessions
Parallel Parallel Parallel E-Poster
14:00 Symposium Symposium Symposium VIP 02
MP 09 - MP 12
BOS 20 - BOS 22
14:05 Plenary 3
15:35 Perfect organ preservation and reconditioning - an elusive dream?
15:35
Break
16:00
INSPIRE & DRIVE 4 Edu Track 5 MDT 3
Moderated Focus corporate Brief Oral
16:00 Engineering the future Ischemia The unthinkable E-Poster Groups (Hands-on) Sessions
17:00 reperfusion donor/recipient MP 13 - MP 16 FG 16 - FG 20 Workshop BOS 23 - BOS 25
injury – still a
challenge?
17:05 corporate
17:30 Elevator (Hands-on)
Corporate Corporate Corporate Full Oral
17:30 Pitch Workshop
Parallel Parallel Parallel Sessions
18:05 EP 04
Symposium Symposium Symposium OS 37 - OS 42
18:05
18:35
TURNING
RESEARCH INTO
18:40 AN AGENT OF Brief Oral
19:10 CHANGE Sessions
19:10 off-site event BOS 26 - BOS 28
19:40 Live from
19:40 Stanford
20:00 University
Wednesday, September 18
7:30 Edu Track 6
8:00 Regenerative Transplantation
8:00
8:30
Full Oral Sessions Brief Oral Sessions
OS LB
OS 43 - OS 48 BOS 29 - BOS 31
8:30
9:00
SOTA 7 SOTA 8 SOTA 9
9:10 Pharmaco Genomics. New imaging techniques Transplant success:
10:40 Are we ready for implementation into the patient’s definition
clinical practice?
10:40
Break
11:10
11:10 Plenary 4 & Presidential Session
13:00 Dealing with organ failure: a change in the direction of travel?ESOT 2019 Copenhagen Committees Congress Chairs Finn Gustafsson, Copenhagen, Denmark Allan Rasmussen, Copenhagen, Denmark Scientific Programme Committee Chairs Vassilios Papalois, London, United Kingdom Allan Rasmussen, Copenhagen, Denmark Members Erik Berglund, Stockholm, Sweden ❚ Menna Clatworthy, Cambridge, United Kingdom ❚ Constantino Fondevila, Barcelona, Spain ❚ Finn Gustafsson, Copenhagen, Denmark ❚ Luuk Hilbrands, Nijmegen, The Netherlands ❚ Franz Immer, Bern, Switzerland ❚ Ina Jochmans, Leuven, Belgium ❚ Nicos Kessaris, London, United Kingdom ❚ Henri Leuvenink, Groningen, The Netherlands ❚ Gavin Pettigrew, Cambridge, United Kingdom ❚ Lorenzo Piemonti, Milan, Italy ❚ Thomas Resch, Innsbruck, Austria ❚ David Rodriguez-Arias, Granada, Spain ❚ Søren Schwartz Sørensen, Copenhagen, Denmark ❚ Luca Toti, Rome, Italy ❚ Andreas Zuckermann, Vienna, Austria Organising Executive Committee Vassilios Papalois, London, United Kingdom ❚ Allan Rasmussen, Copenhagen, Denmark ❚ Annalisa Ponchia, Padova, Italy ❚ Erik Berglund, Stockholm, Sweden ❚ Menna Clatworthy, Cambridge, United Kingdom ❚ Ina Jochmans, Leuven, Belgium ❚ Søren Schwartz Sørensen, Copenhagen, Denmark ❚ Luca Toti, Rome, Italy Local Committee Finn Gustafsson, Copenhagen ❚ Mads Hornum, Copenhagen ❚ Pernille Kofoed-Nielsen, Aarhus ❚ Paul Krohn, Copenhagen ❚ Carina Lund Sørense, Hillerød ❚ Michael Perch, Copenhagen ❚ Vibeke Rømming Sørensen, Copenhagen ❚ Nicolai Schultz, Copenhagen ❚ Helle C. Thiesson, Odense A mbassadors International Committee Ellis Morris Randall, Carmel, USA ❚ Hassan Argani, Tehran, Iran ❚ Ahn Curie, Seoul, South Korea ❚ Roslyn B. Mannon, Birmingham, USA ❚ Elmi Muller, Cape Town, South Africa ❚ John S. Gill, Vancouver, Canada ❚ Krishnakumar Madhavan, Singapore,❚ David Sutherland, Minneapolis, USA ❚ Arvinder Soin, Gurgaon, India ❚ Waldo Conception, Palo Alto, USA The ESOT Council Stefan Schneeberger, President ❚ Thierry Berney, Past President ❚ Vassilios Papalois, President-Elect ❚ Luciano Potena, Treasurer ❚ Gabriel Oniscu, Secretary ❚ Luca Segantini, CEO 8 — #ESOT2019 —
With Councillors:
Oriol Bestard, Barcelona, Spain ❚ Umberto Cillo, Padova, Italy ❚ Frank Dor, London,
United Kingdom ❚ Luuk Hilbrands, Nijmegen, The Netherlands ❚ Maarten Naesens,
Leuven, Belgium ❚ Xavier Rogiers, Ghent, Belgium ❚ Olivier Thaunat, Lyon, France
And
Ivan Knezevic, ECTTA Chair ❚ Robert Langer, EKITA Chair ❚ Christophe Duvoux, ELITA
Chair ❚ Eelco de Koning, EPITA Chair ❚ David Paredes, EDTCO Chair ❚ Emma Massey,
ELPAT Chair ❚ Henri Leuvenink, BSC Chair ❚ Raj Thuraisingham, EC Chair ❚ Gerald
Brandacher, VCA Chair ❚ Marjo Van Helden, ETAHP Chair ❚ Zeeshan Ahktar, YPT Chair ❚
Liset Pengel, CET ❚ Rainer Oberbauer and Thomas Wekerle, TI Editors in Chief
— #ESOT2019 — 9LEGENDA
Types of sessions
Acronym & colour code
n SUS – Specialty Update Symposium
At Speciality Update Symposia leading specialists are invited to present as part of a deep dive into a specific organ or
field within transplantation. Sessions are developed in collaboration with the relevant ESOT Section or Committee. All
transplant professionals are invited to start their congress experience by participating in the Speciality Update Symposia
of their choice.
n PL – Plenary Session
The whole congress gathers for Plenary sessions to experience powerful out-of-the-box presentations delivered by expert
speakers from inside and outside medical science. Plenary sessions energise and inspire the ESOT community while
raising important issues and asking crucial questions that reframe the past and define the future of transplantation.
n SOTA – State of the Art Session
State of the Art sessions offer participants an opportunity to gain a better understanding of the best methods and the most
robust procedures in transplantation. This is a unique opportunity to get a global perspective on transplantation and learn
from a diverse group of peers.
n ID – Inspire & Drive
Inspiring minds and driving progress (the motto of the congress) is the focus on the Inspire & Drive sessions. The sessions
explore the benefits of mentoring among other ways of keeping young transplant professionals driven and inspired to
develop in the field of transplantation.
n EDU – Education Track
Education Track sessions address the always important fundamentals of transplantation. The sessions are aimed at
transplant professionals looking to learn or relearn the elementary aspects of transplantation. Sessions start with a
knowledge gap assessment, continue with presentations from experts and conclude with an assessment on the topics
covered.
n MDT – Multidisciplinary Team Session
MDT sessions bring together the multiple fascinating aspects of transplantation. Key topics are presented and discussed
from the different perspectives, typical of multi-disciplinary teams. The skills discussed are easily transferable to other
fields, even outside medical science. MDT sessions are a prime example of what makes organ transplantation such a rich
and unique field.
n R – Refresher Session
Refresher sessions offer a fresh view on some of the fundamentals of transplantation. Experienced transplant professionals
share new perspectives on some of the most important and well-established topics in transplantation.
n OFF – Offsite event
n SS – Special Session
Sessions with special focus on different matters in transplantation and/or collaborations with other medical societies or
bodies linked to transplantation.
10 — #ESOT2019 —Abstracts Driven sessions
Full Oral Presentation
7 minutes long (5 minutes for presentation, 2 minutes Q&A’s).
Focus Group
10 minutes long (2 minutes for presentation, 8 minutes moderated discussion-Highly scored abstracts to be
allocated for top-level moderated group discussion and SWOT analysis of the submitted work).
Brief Oral
3 minutes long (2 minutes for presentation, 1 minute Q&A’s).
Elevator Pitch
1 slide 1 minute to convince 3 judges, if you succeed you can extend your presentation up to 5 minutes in total.
Moderated e-Poster
5 minutes long (1 minute introduction, 4 minutes discussion).
e-Posters
Your research available to all delegates of the ESOT 2019 via interactive mobile app, which allows to book
individual appointments and discuss your work.
ViP – Video Presentation Session
MPLab – Machine Perfusion Lab
Types of audience
Acronym & colour code based on ESOT Sections & Committees
l ECTTA Cardio Thoracic transplant professionals
l EKITA Kidney transplant professionals
l ELITA Liver and Intestine transplant professionals
l EPITA Pancreas and Islet transplant professionals
l EDTCO Donation & Transplant coordinators
l ELPAT Ethical, Legal and Psychosocial Aspects of Organ Transplantation professionals
l ECTORS Cell Therapy and Organ Regeneration transplant professionals
l BSC Basic Science transplant professionals
l VCA Vascularized Composite Allotransplantation professionsals
l ETAHP Transplant Allied Healthcare Professionals
l YPT Young Professionals in Transplantation
— #ESOT2019 — 11Plenary sessions (PL)
Pl 1 BE INSPIRED, BE DRIVEN - A new perspective on the future of
Medicine: Is Organ Transplantation going to be out of business?
Pl 2 SINGLE CELLS OMIcs GENERATING AN ATLAS TO CHART TRANSPLANT
ORGANS
Pl 3 Perfect organ preservation and reconditioning – an elusive
dream?
Pl 4 & PRESIDENTIAL SESSION - Dealing with organ failure: a change
in the direction of travel?
State of the Art Sessions (SOTA)
SOTA 1 MICROBIOME IN TRANSPLANTATION: FRIEND OR FOE?
SOTA 2 ORGAN ALLOCATION ALGORYTHM
SOTA 3 HOW TO CHOOSE THE RIGHT RESEARCH MODEL
SOTA 4 STEM CELLS AND GENE EDITING - Pluripotent Stem Cells Meet
Genome Editing: a disruptive wedding
SOTA 5 DCD: PUSH THE BOUNDARIES
SOTA 6 SMALL PATIENTS, BIG CHALLENGES
SOTA 7 PHARMACO GENOMICS – Are we ready for implementation into
clinical practice?
SOTA 8 NEW IMAGING TECHNIQUES
SOTA 9 TRANSPLANT SUCCESS: THE PATIENT’S DEFINITION
12 — #ESOT2019 —INSPIRE & DRIVE Sessions (ID)
INSPIRE & DRIVE 1 HOW TO GET TO THE TOP
INSPIRE & DRIVE 2 EVIDENCE BASED PRACTICE IS KILLING THE ART OF
MEDICINE
INSPIRE & DRIVE 3 RELIGHT MY FIRE - “Get back out there and try it
again.”
INSPIRE & DRIVE 4 ENGINEERING THE FUTURE
Education Tracks (EDU)
TRACK 1 IMMUNOLOGY: ABCs and BEYOND
TRACK 2 Tolerance is here to stay
TRACK 3 Xenotransplantation - soon a reality?
TRACK 4 MACHINE PERFUSION GOES PRIME TIME
TRACK 5 ISCHEMIA REPERFUSION INJURY – STILL?
TRACK 6 Regenerative Transplantation
— #ESOT2019 — 13MDT Sessions (MDT) MDT 1 IT’S ALL ABOUT SAFETY MDT 2 THE GREAT ECMO CHALLENGE MDT 3 THE UNTHINKABLE DONOR/RECIPIENT Refresher (R) Refresher 1 TRANSLATIONAL SCIENCE Refresher 2 LEARNING FROM NEIGHBOURING SPECIALITIES Refresher 3 BIG DATA Refresher 4 INFLAMMATION 14 — #ESOT2019 —
Speciality Update Symposia (SUS)
About ECTORS
Goals To facility the integration of regenerative medicine in clinical organ transplantation.
ECTORS Aim Provide a forum for discussing and stimulating novel developments in the fields of cellular
therapies in organ transplantation, organ reconditioning / regeneration and generation of new
European
Cell Therapy and
organ regeneration
Section
organs from stem cells and biomaterials
Learning Objectives Participants will be updated on the state of the art in regenerative med-
icine in the field of organ transplantation.
Target audience Basic scientists, clinicians, corporations interested in stem cell therapy, or-
gan reconditioning and organ regeneration
About BSC
The Basic Science Committee promotes Basic science in transplantation in Europe.
Goals Translation of innovation into clinical activity; Communication between basic scientists
and clinicians; Collaboration between laboratories in Europe.
Target audience Basic Scientists, Transplant immunologists, Regenerative Medicine re-
searchers, Transplant physicians.
About VCA
Vascularized Composite Allotransplantation (VCA) has opened a new chapter in the field of
transplantation, reconstructive, and restorative surgery. This committee brings together 8 repre-
sentatives of major European teams at the forefront in this field.
Goals Our goal is to raise the scientific and clinical development oVf ascularized Composite
Allotransplantation (VCA) in Europe and to serve as a platform for scientists and clinicians for
information and ex change.
Aim This SUS aims to provide an update on clinical outcomes and latest developments in the
field of VCA including upper extremity, face, and uterus transplantation. In addition, we will pro-
vide and outlook on how latest developments in the area of organ preservation and regenera-
tive medicine might shape the future of this innovative field.
Learning Objectives At the end of this SUS the participants will have learned about out-
comes (functional, immunological, psychosocial), as well as complications and potential pit-
falls in the world experience with VCA including upper extremity, face, and uterus transplanta-
tion. The participates will learn to assess the pros and cons of different immunomodulatory
approaches in VCA and get a perspective on the future of the field.
Target audience Surgeons, physicians, researchers, transplant coordinators.
About ECTTA
Bringing back to life heart and lung failure patients: it is time to move away from transplanta-
tion? Will DCD donation and new frontiers for organ preservation and allocation improve surviv-
al and QOL of patients suffering heart and lung failure.?
Establish a role for mechanical support during end-stage heart and lung failure and the relation-
ship with bioengineered organs, regenerative medicine and transplantation.
Improve the long term follow-up: the role of precision medicine in the management of thoracic
transplantation.
Goals A survey will involve the ECTTA members and affiliates in the setup of the program look-
ing at a balanced match between open discussion and state of the art lectures.
Aim The meeting will deal with the recent impulse that Thoracic transplantation has received in
Europe from DCD donation and from the new techniques of organ preservation aiming at pre-
serve more vulnerable organs.
Describe the right use of mechanical replacement or support of thoracic organs (ECMO, VAD, ar-
tificial lungs) and thoracic transplantation in Europe aiming to enlarge the number of patients
treated and their survival and QOL.
— #ESOT2019 — 15Speciality Update Symposia (SUS)
The faculty will also highlight the limitations in the improvement of exercise capacity of patients
receiving thoracic transplantation and mechanical circulatory support and possible solutions to
improve outcomes of destination therapy.
Learning objectives A well balanced mixture of state of the art lectures and open discussion
will allow participants to deal with the new solutions aiming to treat heart and lung failure in the
upcoming future.
Target audience transplant professionals (cardiologists, pneumologists, surgeons, anaes-
thesiologists, VAD and transplant coordinators, expert in rehab medicine).
About ELITA
The European Liver and Intestine Transplantation Association is a multi-disciplinary Society of
health care professionals in liver and intestine transplantation which is the official professional
society delegated by ESOT for liver and intestine transplantation in Europe.
Goals To provide a range of educational activities, stimulate discussion and influence Euro-
pean legislation in liver and intestine transplantation. To stimulate clinical research and publi-
cations from analysis of the registry, in partnership with the European Liver Transplant Registry.
Aim Our aim is to set guidelines and standards and to provide education and support in liver
and intestine transplantation within the European Countries and beyond.
Learning Objectives To learn about the current state of different types machine preserva-
tion in liver transplantation and normothermic regional perfusion in donors after circulatory
death as well in the currents trends and innovations in immunosuppression after liver trans-
plantation.
Target audience Liver transplant surgeons and hepatologists, HPB surgeons and general
hepatologists, specialist nurses in liver transplantation, HPB, hepatology and oncology.
About EKITA
EKITA is the kidney section of ESOT and deals with all aspects of renal transplantation. As a
European platform, EKITA supports research, education and clinical work in this area. Further-
more, EKITA is highly ambitious in preparing policies and creating transnational interactions to
advance renal allografting in all European member states.
Goals The main goal of EKITA is to improve quality of life of people with ESRD by advancing all
aspects of kidney transplantation.
Aims The ultimate aim of EKITA is the optimization of renal transplantation trough activities in
research, education, clinical collaboration and health policy.
LEARNING Objectives To provide an overview on T & B-cell interaction.
Target audience Transplant surgeons and physicians, nephrologist, immunologists at all
stages of training and expertise.
About EPITA
The European pancreas and Islet Transplantation Association is a section of ESOT founded to
provide a Forum for the pancreas and islet transplantation community in Europe.
Goals To facilitate the exchange of information of the field of pancreas and islet transplantation.
Aim The aim of EPITA is to contribute to the development of the pancreas and islet transplan-
tation field and of alternate forms of beta-cell replacement therapy for the benefit of patients
suffering from type 1 diabetes.
Learning Objectives The participant will know what donor characteristics to focus on in the
decision to use marginal donors for pancreas or islet transplantation, how to monitor islet and
pancreas graft rejection and to implement the diagnostic tools to be able to assess the success
of pancreas and islet transplantation.
Target audience: Surgeons, nephrologists, diabetologists, transplant coordinators interested in
pancreas and islet transplantation.
Target audience Transplant surgeons and physicians, transplant coordinator, nurses and
medical student with an interest in transplantation of pancreas and islets.
16 — #ESOT2019 —About EDTCO
EDTCO is a section within ESOT dedicated to donation and procurement activities.
Goals Increase organ and tissue availability. Ensure the quality and safety of organs and tis-
sues for transplantation. Optimise the safety of living donors and care for deceased donors
and their relatives. Optimise potential recipient care and follow-up through effective clinical
coordination.
Aim To establish clinically effective programmes in organ and tissue donation, procurement
and transplantation by supporting and representing all healthcare professionals involved in
the process.
Target audience Healthcare professionals involved in intensive care and emer- gency
medicine, end of life care, organ and tissue donation and coordination. Patient, family and
society representatives, EU commissioners.
About ELPAT
ELPAT is a section of ESOT dedicated to the ethical, legal and psychosocial aspects of organ
donation and transplantation.
Goals ELPAT goals include organizing symposia and conferences, as well as initiating and par-
ticipating in research, and disseminating knowledge through publications and events.
Aim ELPAT aims to stimulate collaboration, innovation and knowledge exchange on ethical, le-
gal and psychosocial aspects of transplantation. We bring continuity and structure to the dia-
logue on these issues and to contribute to development of clinical practice, research and policy.
Learning Objectives A description of what a participant will achieve at the conclusion of the
programme. When writing outcomes, it is helpful to use verbs that are measurable or that de-
scribe an observable action. The best learning objectives will include a description of the condi-
tions (“when given x, you will be able to…”) and the acceptable performance level. After following
these lectures participants will have greater knowledge and understanding of current ethical,
legal and psychosocial challenges in deceased and living donation.
Target audience Physicians, nurses, ethicists, lawyers, psychologists, coordinators.
About ETAHP
ETAHP reaches out to nurses (e.g. clinical nurses, advanced practice n urses and nurse co-
ordinators (recipient care), psychologists, physical therapists, occupational therapists, social
workers, dieticians, pharmacists and other disciplines working in the field of transplantation.
Goals Within ETAHP, nurses and allied healthcare professionals throughout Europe will be
united to ensure the best care possible to all transplant patients, with the aim to optimize
patient outcomes.
Aims We will do so by creating a strong European interdisciplinary platform to: share evidence
based knowledge; exchange experiences and provide training; facilitate research and clinical
collaborations; set the standards for the quality of care in transplant nursing and for allied
health professionals.
Learning Objectives After the SUS the participant will be able to identify and overcome
barriers for implementation of knowledge into transplant practice and to recognize and de-
velop leadership behaviours that support EBP, manage risk associated with medicine use, re-
duce errors and incident reporting (open and honest culture/organisations with memory etc).
Target audience Nurses and Allied Healthcare Professionals in Transplantation.
— #ESOT2019 — 17SATURDAY, September 14
scientific programme
1st ECTORS meeting
09:00 – 19:00 The content of this meeting is centred around the state of the art of regenerative medicine in
organ transplantation and its road to clinical application.
09:00 – 09:30 Welcome and review 2008 - 2018
Marc Dahlke, Regensburg, Germany; Martin Hoogduijn, Rotterdam, The Netherlands
09.30 – 11.00 Session 1: Stem cells new developments
Chairs: Marc Dahlke, Regensburg, Germany; Martin Hoogduijn, Rotterdam, The Netherlands
MSC mechanisms of action
Francesco Dazzi, London, United Kingdom
MSC in organ injury
Rafael Kramann, Aachen, Germany
Liver organoids from adult stem cells
Luc van der Laan, Rotterdam, The Netherlands
11.00 – 11.30 COFFEE BREAK
11.30 – 13.00 Session 2: Cell therapy clinical trials
Chairs: Marcella Franquesa, Barcelona, Spain Christian Johnson, Regensburg, Germany
MSC in clinical kidney transplantation
Norberto Perico, Bergamo, Italy
From phase 1 to phase 2 clinical trials with MSC in kidney transplantation
Marlies Reinders, Leiden, The Netherlands
Lessons from other phase 1 trials
Jens Kastrup, Copenhagen, Denmark
13.00 – 14.00 Lunch
14.00 – 15.30 Session 3: Organ reconditioning
Chairs: Sarah Hosgood, Cambridge, United Kingdom; Marlies Reinders, Leiden, The Netherlands
Kidney machine perfusion
Sarah Hosgood, Cambridge, United Kingdom
Liver machine perfusion
Nicholas Gilbo, Leuven, Belgium
Regeneration on the pump
Rutger Ploeg, Oxford, United Kingdom
15.30 – 16.00 COFFEE BREAK
16.00 – 17.30 Session 4: Corporate session
Chairs: Martin Hoogduijn, Rotterdam, The Netherlands; Chris Johnson, Regensburg, Germany
18 — #ESOT2019 —Sunday, September 15
09:00 – 10.00 Session 5: Abstract presentations
Chairs: Federica Casiraghi, Bergamo, Italy; Marc Dahlke, Regensburg, Germany
10.00 – 10.50 Keynote lecture: The use of pluripotent stem cells for organ regeneration
Nuria Montserrat, Barcelona, Spain
10.50 – 11.20 Coffee/tea
Joint session with VCA and BSC
11.20 – 12.50 VCA quo vadis?
11:20 – 11:50 Advances in organ preservation and machine perfusion: potential impact on VCA
Annemarie Weissenbacher, Oxford University, United Kingdom / Innsbruck Medical University, Austria
11:50 – 12:20 Thinking outside the box: Combining VCA and regenerative medicine?
Robert Rieben, Bern, Switzerland
12:20 – 12:50 Cell-based immunoregulation and tolerance induction: are we getting any closer?
Fadi Issa, Oxford University, United Kingdom
12.50 closing
09:00 – 12:50
VCA Specialty Update Symposium
OUTCOMES IN VCA
09:00 – 11:00 Session 1: The Good, the Bad, and the Ugly
09:00 – 09:30 Upper extremity transplantation
Christina Kaufman, Louiseville, United States
09:30 – 10:00 Face transplantation
Laurent Lantieri, Paris, France
10:00 – 10:30 Uterus transplantation
Matt Brannstrom, Gothenburg, Sweden
10:30 – 11:00 Immunomodulatory protocols
Gerald Brandacher, Baltimore, United States
11:00 – 11:20 COFFEE BREAK
Joint session with BSC & ECTORS
11.20 – 12.50 VCA quo vadis?
11:20 – 11:50 Advances in organ preservation and machine perfusion: potential impact on VCA
Annemarie Weissenbacher, Oxford University, United Kingdom / Innsbruck Medical University, Austria
11:50 – 12:20 Thinking outside the box: Combining VCA and regenerative medicine?
Robert Rieben, Bern, Switzerland
12:20 – 12:50 Cell-based immunoregulation and tolerance induction: are we getting any closer?
Fadi Issa, Oxford University, United Kingdom
12.50 closing
— #ESOT2019 — 19Sunday, September 15
scientific programme
09:00 – 12:50 ECTTA Specialty Update Symposium
09:00 – 09:40 To die or not to die?
Chair: Arne Neyrinck, Leuven, Belgium; David Paredes, Barcelona, Spain
09:00 – 09:10 Physiological benefit
David Paredes, Barcelona, Spain
09:10 – 09:20 Ethical counterparts
Eline Bunnick, Rotterdam, The Netherlands
09:20 – 09:40 Discussion
09:40 – 10:20 NRP do not harm my organs
Chair: Michiel Erasmus, Groningen, The Netherlands; Edouard Sage, Paris, France
09:40 – 09:50 Over the diaphragm
Stephen Large, Papworth, United Kingdom
09:50 – 10:00 Under the diaphragm
Benoit Barrou, Paris, France
10:00 – 10:20 Discussion
10:20 – 10:40 COFFEE BREAK
10:40 – 11:35 Part 1
Chair: Robin Vos, Leuven, Belgium; Andreas Zuckerman, Vienna, Austria
10:40 – 10:55 Over Europe organ exchange
Jacqueline Smiths, Leiden, The Netherlands
10:55 – 11:05 Xenotransplantation is the future of heart transplantation
Sebastian Michel, Munchen, Germany
11:05 – 11:20 Bioengineered heart and lungs
Darcy Wagner, Lund, Sweden
11:20 – 11:35 Q&A
11:35 – 12:50 Part 2
Chair: Cristiano Amarelli, Naples, Italy; Johan Nilsson, Lund, Sweden
11:35 – 11:50 Patient-LVAD interaction
Pia Jury, Astsana, Kazakhstan
11:50 – 12:05 Towards the artificial lung: technical limitations and future opportunities
Simon Sonntag, Aachen, Germany
12:05 – 12:20 Mechanical biventricular option
Arnt Fiane, Oslo, Norway
12:20 – 12:50 Panel interactive debate: machines will overcome
Pro: Mechanical heart is already here
Jan Schmitto, Hannover, Germany
Con: Transplant of biological organs is still invincible
Ivan Knezevic, Ljubljana, Slovenia
20 — #ESOT2019 —09:00 – 12:50 ELITA Specialty Update Symposium
Machine Perfusion and Immunosuppression in Liver Transplantation – the
Best from Both Worlds
09:00 – 09:05 Introduction
Christophe Duvoux, Paris, France
9.05-10.50 SESSION 1: Machine contest
Chairs: Constantino Fondevila, Barcelona, Spain; Wojciech Polak, Rotterdam, The Netherlands
Round 1 - Cold vs Warm
Hypothermic machine perfusion vs Normothermic machine perfusion
09:05 – 09:20 Hypothermic – cold is cool!
Presentation by junior – Otto van Leeuwen, Groningen, The Netherlands
Mentor: Robert Porte, Groningen, The Netherlands
09:20 – 09:35 Normothermic – warm is sexy!
Presentation by junior – Rohit Gaurav, Cambridge, United Kingdom
Mentor: Chris Watson, Cambridge, United Kingdom
09:35 – 09:50 What’s is this fuzz about? Just rewarm it!
Presentation by junior – Charlotte von Horn, Essen, Germany
Mentor: Thomas Minor, Essen, Germany
09:50 – 10:10 Debate supported by mentors
Robert Porte, Groningen, The Netherlands & Christopher Watson, Cambridge, United Kingdom
& Thomas Minor, Essen, Germany
Round 2
Regional perfusion vs Ex-situ perfusion in DCD
10:10 – 10:25 Normothermic regional perfusion – let’s asses the liver in the donor
Presentation by junior – Ahmed Sherif, Edinburgh, United Kingdom
Mentor: Gabriel Oniscu, Edinburgh, United Kingdom
10:25 – 10:40 Ex-situ perfusion – be quick and do it ex-situ!
Presentation by junior – Nicholas Gilbo, Leuven, Belgium
Mentor: Ina Jochmans, Leuven, Belgium
10:40 – 10:50 Debate supported by mentors
Gabriel Oniscu, Edinburgh, United Kingdom & Ina Jochmans, Leuven, Belgium
10:50 – 11:10 COFFEE BREAK
11.10 – 12.50 SESSION 2: 30 years of immunosuppression: Is there such a thing as protocol
immunosuppression in liver transplantation?
Chairs: Marina Berenguer, Valencia, Spain; Giacomo Germani, Padova, Italy
11.10 – 11.30 Individualized immunosuppression: when and how
Manuel Rodriguez Peralvarez, Cordoba, Spain
11.30 – 12.10 Antibody mediated rejection: a real problem in LT?
Pathologist point of view
Mylene Sebagh, Paris, France
Clinician point of view
Christophe Duvuox, Paris, France
12.10 – 12.30 Risks and benefits associated with minimization of immunosuppression
Patrizia Burra, Padova, Italy
12.30 – 12.50 Establishing the net status of immunosuppression: the holy grail of transplantation
Alberto Sanchez Fueyo, London, United Kingdom
— #ESOT2019 — 21Sunday, September 15
scientific programme
09:00 – 12:50 EKITA Specialty Update Symposium
09:00-10:40 SESSION 1: – Interaction of B &T-cell alloimmunity
Chairs: Robert Langer, Linz, Austria; Luuk Hilbrands, Nijmegen, The Netherlands
09:00 – 09:20 T & B-cell interaction
Gavin Pettigrew, Cambridge, United Kingdom
09:20 – 09:40 Complement system – novel insights in alloimmunity
Olivier Thaunat, Lyon, France
09:40 – 10:00 Lymphocyte receptor repertoire – new opportunities
Rainer Oberbauer, Vienna, Austria
10:00 – 10:20 Eplet matching. How to and is it better?
Nils Lachman, Berlin, Germany
10:20 – 10:40 Spontaneous operational tolerance – does it exist?
Annick Massart, Brussels, Belgium
10:40 – 11:00 COFFEE BREAK
11:00-12:50 SESSION 2: – Complication management in the patient
Chairs: Gabriel Oniscu, Edinburgh, United Kingdom; Lucrezia Furian, Padova, Italy
11:00 – 11:25 Treatment of ABMR – is there any?
Menna Clathworthy, Cambridge, United Kingdom
11:25 – 11:50 The multiple transplant patient – what are the challenges?
Maria Irene Bellini, London, United Kingdom
11:50 – 12:15 Non-technical approaches to management of surgical complications
Nizam Mamode, London, United Kingdom
12:15 – 12:40 Practicability of the COMMIT guidelines for the kidney graft
Franco Citterio, Rome, Italy
12:40 – 12:50 Past, Present and Future of EKITA
Robert Langer, Linz, Austria
09:00 – 12:50 EPITA Specialty Update Symposium
09:00 – 10:30 SESSION 1: – Marginal donors
Chairs: Helmut Arbogast, Heidelberg, Germany; Roger Lehmann, Zurich, Switzerland
09:00 – 09:30 Where have all the pancreas gone?
Steve White, Newcastle, United Kingdom
09:30 – 10:00 Expanding donor characteristics: results from the EXPAND trial
Stefan Farkas, Regensburg, Germany
10:00 – 10:30 Using DCD pancreas for islet isolation
Marten Engelse, Leiden, The Netherlands
10:30 – 11:00 COFFEE BREAK
11:00 – 12:50 SESSION 2: – Monitoring rejection and outcome assessment
Chairs: Eelco de Koning, Leiden, The Netherlands; Julie Kerr-Conte, Lille, France
11.00 – 11.30 How to close the gap in pancreas graft outcome between SPK and solitary pancreas Tx?
Thierry Berney, Geneva, Switzerland
22 — #ESOT2019 —11.30 – 12.00 Islet graft monitoring for rejection
Marie-Christine Vantyghem, Lille, France
12.00 – 12.30 Defining the outcome of pancreas and islet graft function
Michael Rickels, Philadelphia, United States
12:30 – 12:50 Q&A
09:00 – 12:50 EDTCO Specialty Update Symposium
09:00 – 09:40 To die or not to die?
Chair: Arne Neyrinck, Leuven, Belgium; David Paredes, Barcelona, Spain
09:00 – 09:10 Physiological benefit
David Paredes, Barcelona, Spain
09:10 – 09:20 Ethical counterparts
Eline Bunnick, Rotterdam, The Netherlands
09:20 – 09:40 Discussion
09:40 – 10:20 NRP do not harm my organs
Chair: Michiel Erasmus, Groningen, The Netherlands; Edouard Sage, Paris, France
09:40 – 09:50 Over the diaphragm
Stephen Large, Papworth, United Kingdom
09:50 – 10:00 Under the diaphragm
Benoit Barrou, Paris, France
10:00 – 10:20 Discussion
10:20 – 10:40 COFFEE BREAK (&split)
11:00 – 11:20 Expanded organ donor
TBA
11:20 – 12:00 Organ donation – 3 challenge cases
12:00 – 12:20 Expanded tissue donor
12:20 – 12:50 Tissue donation – 2 challenge cases
09:00 – 12:50 ELPAT Specialty Update Symposium
CHALLENGING THE MINDSET ON DONATION
09.00 – 10.30 SESSION 1
Chairs: Antonia Cronin, London, United Kingdom; Emma Massey, Rotterdam, The Netherlands
09:00 – 09:30 Death determination in DCD and DBD.
Anne Dalle Ave, Lausanne, Switzerland
09:30 – 10:00 Should we facilitate organ donation by patients who wish to die? Ethical and legal boundaries.
Penney Lewis, London, United Kingdom
10:00 – 10:30 Opinion polls, public perception and practice: How do the public view opt-in versus opt-out?
David Rodriguez-Arias, Granada, Spain
10:50 – 11:10 COFFEE BREAK
— #ESOT2019 — 23Sunday, September 15
scientific programme
11:00 – 12:50 SESSION 2
Chairs: Antonia Cronin, London, United Kingdom; Emma Massey, Rotterdam, The Netherlands
11.00 – 11.30 Banking on living donors? The ethics of advanced living organ donation.
Dominique Martin, Victoria, Australia
11.30 – 12.00 Increasing opportunities for pre-emptive transplantation.
David van Dellen, Manchester, United Kingdom
12.00 – 12.30 Should organ sales be decriminalized?
Sean Columb, Liverpool, United Kingdom
12:30 – 12:50 Q&A
09:00 – 12:50 ETAHP Specialty Update Symposium
09.00 – 12.50 FASTEN YOUR SEATBELTS- HOW TO JOIN THE RIDE OF EVIDENCE BASED PRACTICE
The art of overcoming barriers for EBP
09:00 – 10:00 How to make a safe trip-identify the reasons why knowledge do not get used in practice-
Hester Vermeulen, Nijmegen, The Netherlands
10:00 – 10:45 Learning from our mistakes- safe medication practice
Clare Crowley, Oxford, United Kingdom
10:45 – 11:00 COFFEE BREAK
11:00 – 12:00 Profound knowledge of improvement- tools to improve the practice including examples of
successful quality improvement
Ann-Christine Andersson, Jönköping, Sweden
12:00 – 12:45 Identify and overcome your own barriers “practice”
Ann-Christine Andersson, Jönköping, Sweden & Anna Forberg, Lund, Sweden
12:45 – 12:50 Closing
09:00 – 12:50 YPT Workshop
About YPT
The Young Professionals in Transplantation (YPT) is the Network for Junior Transplant professionals of ESOT. It has
been created to represent all young transplant clinicians and scientists who are beginning a career in transplanta-
tion and organ donation. YPT provides a forum for the junior professionals throughout Europe, working in the field
of transplantation to discuss their needs and support their improvement.
By creating a network based on a “younger perspective” we want to address our issues and facilitate the collabo-
ration and friendship across international borders. We provide a platform for information, communication and
exchange between young transplant professionals who want to enhance their knowledge in transplantation and
provide the opportunity to be actively involved in inter national clinical and scientific exchange programs.
Goals The group was designed to establish and maintain a network of young ESOT members under the age of 40
years, who want to become clinical and/or scientific experts in the field of transplantation.
YPT is actively involved in the ESOT Biennial Meeting, or ganizing innovative sessions dedicated to junior profes-
sionals and arranging networking events to contact all young professionals and share their ideas.
Aims YPT wants to hel p young transplant professionals to enter the communi ty of E SOT and therefore represents
ESOT as a clinical, scientific and especially educational entity, w hich can help young professionals in their indi-
vidual career development.
We collaborate closely with the Educational Committee in order to endorse high scientific and clinical standards
for every YPT member.
24 — #ESOT2019 —Together we promote educational programs and are actively involved in the organization of cutting-edge sci-
entific sessions, career development meetings and networking events on ESOT-associated congresses all over
Europe through international collaboration with the national transplant societies.
Innovation Workshop
Chair: Thomas Resch, Innsbruck, Austria
09:00 – 10:00 Crisis management. Negotiating in times of crises
Sir Stewart Eldon, Former United Kingdom Ambassador to NATO and Ireland, United Kingdom
09:20 – 09:30 Discussion
09:20 – 09:30 Learning
Interview with...
Interviewer Thomas Resch, Innsbruck, Austria
09:30 – 09:45 Interview with: the Airline Pilot
09:45 – 10:00 Interview with: the CEO
10:00 – 10:15 Interview with: the Surgeon
10:15 – 10:30 Wrap up & take home message
10:30 – 10:40 COFFEE BREAK
10:40 – 11:40 Shark Tank Session
Chair: Zeeshan Akhtar, Oxford, United Kingdom; Sushma Shankar, Oxford, United Kingdom
Sharks: Sir Stewart Eldon; John Piano; Annalisa Ponchia
11:40 – 12:00 YPT activities
11:40 – 11:55 Winner of YPT fellowship: “My experience” - together with Mentor
11:55 – 12:05 “Get on the YPT-Map!”
10:30 – 10:40 COFFEE BREAK
12:10 – 12:50 Board Election
13:30 – 15:00 EDUCATION TRACK 1
Created by Luca Toti, Rome, Italy
Immunology: ABCs and Beyond
Chairs: Menna Clatworthy, Cambridge, United Kingdom; Anthony Warrens, London, United Kingdom
13:30 – 13:45 Introduction by Story teller & pre-assessment quiz
Giuseppe Tisone, Rome, Italy
13:45 – 14:05 Overview: HLA and Immunology
Sebastiaan Heidt, Leiden, The Netherlands
14:05 – 14:25 The high immunological risk recipient
Christophe Legendre, Paris, France
14:25 – 14:45 The T and B cells in your transplant practice
Carla Baan, Rotterdam, The Netherlands
14:45 – 15:00 Post assessment quiz
Giuseppe Tisone, Rome, Italy
— #ESOT2019 — 25Sunday, September 15
scientific programme
13:30 – 15:00 MDT 1
Created by: Nicos Kessaris, London, United Kingdom
IT’S ALL ABOUT SAFETY - High performance, risk and safety lessons in transplantation
13:30 – 13:50 Building resilient systems in healthcare
13:50 – 14:10 Threat and error management in surgery
Niall Downey, London, United Kingdom
14:10 – 14:30 Human performance in crisis – a study in transplant surgery
Petrut Gogalniceanu, London, United Kingdom
14:30 – 15:00 MDT discussion
All involved
13:30 – 14:30 REFRESHER 1
The wonders of basic research: the clinical needs translational research the fastest and most efficient way from one to another.
Created by: Henri Leuvenink, Groningen, The Netherlands; Gavin Pettigrew, Cambridge, United Kingdom
Translational science
Chairs: Katja Kotsch, Berlin, Germany; Gavin Pettigrew, Cambridge, United Kingdom
13:30 – 13:45 Clinical models on warm perfusion and organ manipulation
Cyril Moers, Groningen, The Netherlands
13:45 – 14:00 Pre-clinical modelling of the alloimmune response
Giovanna Lombardi, London, United Kingdom
14:00 – 14:15 Why bother about pre-clinical models?
Carla Baan, Rotterdam, The Netherlands
14:15 – 14:30 Panel discussion
15:10 – 16:40 ESOT & IPTA JOINT SESSION
The Clinical Realization of Progress in Pediatric Transplantation
15:10 – 15:30 Interspecies Chimerism and Organ Generation; from miracle to reality
15:30 – 15:50 Clinical Realization of Organ Reconditioning and Repair
15:50 – 16:10 Liver Splitting during Machine Perfusion: fact or phantasy?
16:10 – 16:30 Tolerance induction in Pediatric Organ Transplantation: pros and cons
16:30 – 16:40 Q&A
26 — #ESOT2019 —15:10 – 16:40 EUTRAIN CALLING: 1st stop Copenhagen!
15:10 – 15:25 Station master’s announcement: The EUTRAIN consortium
Carmen Lefaucheur, Paris, France
15:25 – 15:40 Methodomics
Olivier Aubert, Paris, France
15:40 – 15:55 The future of biomarker guided patient care in solid organ transplantation
Oriol Bestard, Barcelona, Spain
15:55 – 16:10 Molecular platform for precision diagnostics, data integration and analytics
Alexandre Loupy, Paris, France
16:10 – 16:30 Now get your boarding pass ready: How to catch the (EU-) TRAIN?
Yassine Bouatou, Paris, France
16:30 – 16:40 Awards
Carmen Lefaucheur & Alexandre Loupy, Paris, France
15:10 -16:40 MDT 2
Created by: EDTCO, ECTTA, BSC
The great ECMO challenge! (Joint EDTCO/ECTTA/BSC)
Chairs: Ivan Knezevic, Ljubljana, Slovenia; David Paredes, Barcelona, Spain; Henri Leuvenink, Groningen, The Netherlands
15:10 – 15:30 Setting the scene
15:30 – 16:30 CLINICAL CASES – Open discussion with audience with live voting (per-case discussion)
15:30 – 15:40 AV ECMO patient complicated with catastrophic cerebral damage
Arne Neyrinck, Leuven, Belgium
15:40 – 15:50 Discussion & Live Voting
15:50 – 16:00 NRP as organ rescue therapy in sudden irreversible CA in already diagnosed DBD
16:00 – 16:10 Discussion & Live Voting
16:10 – 16:20 NRP after circulatory death declaration, as organ rescue therapy in already diagnosed DBD, in
countries where BD concept is not “well understood or accepted by relatives, as death concept”
David Paredes, Barcelona, Spain
16:20 – 16:30 Discussion & Live Voting
16:30 – 16:40 Take home message via wordcloud
— #ESOT2019 — 27Sunday, September 15
scientific programme
15:10 -16:40 Special session
Antibody mediated rejection and complement. Brothers in arms?
Chairs: Luuk Hilbrands, Nijmegen, The Netherlands; Henri Leuvenink, Groningen, The Netherlands
15:10 – 15:25 Role of non-HLA antibodies in antibody mediated rejection
Dany Anglicheau, Paris, France
15:25 – 15:40 How does antibody binding induce graft injury?
Olivier Thaunat, Lyon, France
15:40 – 15:55 Tough-refractory AMR: are we ready to throw the towel?
David Taube, London, United Kingdom
15:55 – 16:10 Management of aHUS in kidney transplant patients: Eculizumab for once and for all?
Caroline Duineveld, Nijmegen, The Netherlands
16:10 – 16:25 Next generation complement inhibitors
Søren Pischke, Oslo, Norway
16:25 – 16:40 Q&A
15:10 -16:40 CORPORATE PARALLEL SYMPOSIA
17:00 – 19:00 PLENARY 1
Created by: Finn Gustafsson, Copenhagen, Denmark; Allan Rasmussen, Copenhagen, Denmark
“Nothing in biology make sense except in the light of evolution” (Theodosius Dobzhansky)
Why do we have diseases such as Parkinson’s disease, depression, and schizophrenia?
If the concept “evolution” really works, these conditions should have been removed from our genes long times ago.
Maybe the explanation is, that these genes constitute an advantage under other circumstances than those we have
today. If this is so, we can find the explanation by studying DNA in ancient times. The study of evolution of diseases
in this way may change our understanding of how, why, and when we get these kinds of diseases determined by
our genes. Professor Eske Willerslev is one of the World’s leading DNA-scientists. Today we know a lot of diseases
caused by our genetic constitution, and Eske Willerslev believes that this research will make us able to map most
of the genomes leading to diseases.
Having this knowledge, we will be able to take over the “responsibility” of the evolution. It will be possible to test
embryos for the unwanted genomes and consequently offer abortion or via Crispr based technique to manipulate
the genome. Therefore, we do not have to wait for the natural evolution to remove the genes causing disease when
the advantages of having the genome vanished many generations ago.
This, obviously, raises several ethical questions on which we must decide. When we have the knowledge about
the genes causing disease, we cannot avoid decisions. To leave a person with a disease causing genome is also
a decision. This may be a relatively easy decision if the genome causes a mild or a life-threatening disease. In
between, it will be extremely difficult. And one thing is for sure, there will be enormous disagreement.
Finally, an interesting thought in relation to organ transplantation. Most diseases leading to organ failure treated by
transplantation are related to our genomic structure.
BE INSPIRED, BE DRIVEN: A new perspective on the future of Medicine.
Is Organ Transplantation going to be out of business?
Chairs: Finn Gustafsson, Copenhagen, Denmark; Allan Rasmussen, Copenhagen, Denmark
17:00 – 17:10 Welcome by the Congress Chairs
17:10 – 17:40 KEYNOTE LECTURE
Eske Willerslev, Copenhagen, Denmark
28 — #ESOT2019 —17:40 – 18:00 About CRISPR technique
Cord Herbert Brakebusch, Copenhagen, Denmark
18:00 – 18:20 Ethical question?
Rasmus Grønfeldt Winther, Santa Cruz, United States
18:20 – 19:00 Honorary Membership Ceremony
— #ESOT2019 — 29Monday, September 16
scientific programme
07:30 - 09:00 EDUCATION TRACK 2
Created by Luca Toti, Rome, Italy
Tolerance is here to stay
Chairs: Menna Clatworthy, Cambridge, United Kingdom; Alberto Sanchez-Fueyo, London, United Kingdom
07:30 – 07:45 Introduction by Story teller & pre-assessment quiz
Luca Toti, Rome, Italy
07:45 – 08:05 Regulatory cells and tolerance
David Berglund, Uppsala, Sweden
08:05 – 08:25 Tolerance in kidney transplantation
David Sachs, Boston, United States
08:25 – 08:45 Tolerance in liver transplantation
Giovanna Lombardi, London, United Kingdom
08:45 – 09:00 Post assessment quiz
Luca Toti, Rome, Italy
09:10 - 10:40 STATE OF THE ART 1
Created by: Menna Clatworthy, Cambridge, United Kingdom; Gavin Pettigrew, Cambridge, United Kingdom
This is a high profile topic in biomedical research, as evidenced by the fact that many of the papers are published
in the journals with the highest impact factors, Nature, Science, Cell etc.
MICROBIOME IN TRANSPLANTATION: FRIEND OR FOE?
09:10 – 09:40 Transmission of the gut microbiome as an immunomodulatory therapeutic strategy
09:40 – 10:00 The microbiome and transplant tolerance
Sophie Brouard, Nantes, France
10:00 – 10:20 The intestinal microbiome and rejection
Marisa Alegre, Chicago, United States
10:20 – 10:40 Q&A
09:10 - 10:40 STATE OF THE ART 2
Created by: Franz Immer, Zurich, Switzerland; David Rodriguez-Arias, Granada, Spain
Organ allocation is one of the key elements in-between organ donation and transplantation.
As such, it takes place in a challenging framework. While it is guided by and must follow specific allocation prin-
ciples, it often takes place in circumstances where time and/or information is limited, and it usually involves an
interdisciplinary group of health care professionals.
Additional factors that may influence the allocation process can include logistics, availability of resources, and
organisational structures.
ORGAN ALLOCATION ALGORITHM - Heartless mathematics? How arithmetic impacts on organ allocation
Chairs: Franz Immer, Zurich, Switzerland; David Rodriguez-Arias, Granada, Spain
09:10 – 09:40 Very complicated math – reconfiguring organ allocation
09:40 – 10:00 Ethical Dilemmas in Liver Transplant Organ Allocation: Is it Time for a New Mathematical Model
Aaron Ahearn, Los Angeles, United States
30 — #ESOT2019 —You can also read
