EuroBioTox: European programme for the establishment of validated procedures for the detection and identification of biological toxins - The ...
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EuroBioTox:
European programme for the establishment of
validated procedures for the detection and
identification of biological toxins
Dr. Brigitte Dorner, Dir. and Prof.
Biological Toxins (ZBS3), Robert Koch Institute, Berlin, DE
CERIS Meeting, 9th Nov 2022
Brussels
Biological toxinsdurch
Titelmasterformat as biothreat agents
Klicken bearbeiten
Accociated Press News, 14 June 2018
https://www.apnews.com/0c9f61222765459890bcf0dd7cffb482/Prosecutor:-
Man-makes-deadly-toxin-for-an-attack-in-Germany
9th Nov 2022 / Brigitte Dorner / CERIS Meeting
Biological toxinsdurch
Titelmasterformat as biothreat agents
Klicken bearbeiten
Accociated Press News, 14 June 2018
26.03.2020
https://www.apnews.com/0c9f61222765459890bcf0dd7cffb482/Prosecutor:-
Man-makes-deadly-toxin-for-an-attack-in-Germany
Main suspect sentenced to 10 years in
prison; his wife to 8 years in prison
https://www.ksta.de/koeln/terroranschlag-geplant-gericht-faellt-
urteil-im-rizin-bomber-prozess-36472666
9th Nov 2022 / Brigitte Dorner / CERIS Meeting
Biological toxinsdurch
Titelmasterformat as biothreat agents
Klicken bearbeiten
Accociated Press News, 14 June 2018
Indonesia, 2019
26.03.2020
https://www.apnews.com/0c9f61222765459890bcf0dd7cffb482/Prosecutor:-
Man-makes-deadly-toxin-for-an-attack-in-Germany
Main suspect sentenced to 10 years in
prison; his wife to 8 years in prison
https://www.ksta.de/koeln/terroranschlag-geplant-gericht-faellt-
urteil-im-rizin-bomber-prozess-36472666
9th Nov 2022 / Brigitte Dorner / CERIS Meeting
Biological toxinsdurch
Titelmasterformat as biothreat agents
Klicken bearbeiten
Accociated Press News, 14 June 2018
Indonesia, 2019
26.03.2020
Morocco, 2016: Clandestine lab of
a suspected terrorist cell exposed
https://www.apnews.com/0c9f61222765459890bcf0dd7cffb482/Prosecutor:-
Man-makes-deadly-toxin-for-an-attack-in-Germany
Main suspect sentenced to 10 years in
prison; his wife to 8 years in prison
https://www.ksta.de/koeln/terroranschlag-geplant-gericht-faellt-
urteil-im-rizin-bomber-prozess-36472666
http://www.ibtimes.com/arrested-isis-militants-morocco-planned-biological-attacks-report-2329753
Press release as of 19.02.2016, BCIJ, Marocco
9th Nov 2022 / Brigitte Dorner / CERIS Meeting
Biological toxinsdurch
Titelmasterformat as biothreat agents
Klicken bearbeiten
04.04.2002
Accociated Press News, 14 June 2018
Indonesia, 2019
26.03.2020
Morocco, 2016: Clandestine lab of
a suspected terrorist cell exposed
https://www.apnews.com/0c9f61222765459890bcf0dd7cffb482/Prosecutor:-
Man-makes-deadly-toxin-for-an-attack-in-Germany
Main suspect sentenced to 10 years in
prison; his wife to 8 years in prison
https://www.ksta.de/koeln/terroranschlag-geplant-gericht-faellt-
urteil-im-rizin-bomber-prozess-36472666
http://www.ibtimes.com/arrested-isis-militants-morocco-planned-biological-attacks-report-2329753
Press release as of 19.02.2016, BCIJ, Marocco
9th Nov 2022 / Brigitte Dorner / CERIS Meeting
Biological toxinsdurch
Titelmasterformat as biothreat agents
Klicken bearbeiten
04.04.2002
Accociated Press News, 14 June 2018
Indonesia, 2019
What do we learn from these incidents?
26.03.2020
Toxins can be and have been prepared by laypersons and can be intentionally released in
a criminal act to harm people.
Morocco, 2016: Clandestine lab of
a suspected terrorist cell exposed
It is not clear how well we are prepared for a potential biotoxin incident.
https://www.apnews.com/0c9f61222765459890bcf0dd7cffb482/Prosecutor:-
Man-makes-deadly-toxin-for-an-attack-in-Germany
Main suspect sentenced to 10 years in
prison; his wife to 8 years in prison
https://www.ksta.de/koeln/terroranschlag-geplant-gericht-faellt-
urteil-im-rizin-bomber-prozess-36472666
http://www.ibtimes.com/arrested-isis-militants-morocco-planned-biological-attacks-report-2329753
Press release as of 19.02.2016, BCIJ, Marocco
9th Nov 2022 / Brigitte Dorner / CERIS Meeting
State Actorsdurch
Titelmasterformat – facts or fiction:
Klicken bearbeiten
Suspected attacks or politically motivated accusations?
Aug 20, 2022
Russia's defence ministry accused Ukraine on Saturday of
poisoning some of its servicemen in the Russian-controlled part
of Ukraine's southeastern region of Zaporizhzhia in late July.
An adviser to Ukraine's interior ministry said in response that
the alleged poisoning could have been caused by Russian forces https://www.farsnews.ir/en/news/14010529000818/Rssia-Says-Prf-f-
eating expired canned meat. Ukraine%27s-%27Chemical-Terrrism%27-Be-Sen-OPCW-Sn
The Russian defence ministry said a number of Russian
servicemen had been taken to a military hospital with signs of
serious poisoning on July 31. Tests showed a toxic substance,
botulinum toxin type B, in their bodies, it said.
https://www.reuters.com/world/europe/russia-accuses-
ukraine-poisoning-some-its-soldiers-2022-08-20/
9th Nov 2022 / Brigitte Dorner / CERIS Meeting
State Actorsdurch
Titelmasterformat – facts or fiction:
Klicken bearbeiten
Suspected attacks or politically motivated accusations?
Aug 20, 2022
Russia's defence ministry accused Ukraine on Saturday of
poisoning some of its servicemen in the Russian-controlled part
of Ukraine's southeastern region of Zaporizhzhia in late July.
An adviser to Ukraine's interior ministry said in response that
the alleged poisoning could have been caused by Russian forces https://www.farsnews.ir/en/news/14010529000818/Rssia-Says-Prf-f-
eating expired canned meat. Ukraine%27s-%27Chemical-Terrrism%27-Be-Sen-OPCW-Sn
The Russian defence ministry said a number of Russian
servicemen had been taken to a military hospital with signs of
serious poisoning on July 31. Tests showed a toxic substance, True or not true? Hybrid warfare!
botulinum toxin type B, in their bodies, it said.
If requested in an international investigation,
https://www.reuters.com/world/europe/russia-accuses-
ukraine-poisoning-some-its-soldiers-2022-08-20/ who would perform BoNT analysis?
9th Nov 2022 / Brigitte Dorner / CERIS Meeting
Biological toxins are regulated
Titelmasterformat durch under
Klickenthe BCW and CWC
bearbeiten
Adopted from Graham S Pearson and Robert Mathews
9th Nov 2022 / Brigitte Dorner / CERIS MeetingDetection of biological
Titelmasterformat durchtoxins:
KlickenAbearbeiten
challenge
Ricin / Abrin: Botulinum toxins:
RNA-N-glycosidases Neurotoxins
>> accidental intoxications >> botulism
LD50: 3 µg/kg (inhalation) LD50: 1 ng/kg (inhalation)
Saxitoxin: Staphylococcal enterotoxins:
Na+ channel blocker Superantigens
>> food intoxications >> food intoxications
LD50: 6 µg/kg (oral) LD50: 27 ng/kg (inhalation)
Dorner BG et al., (2016) Trends in Analytical Chemistry 85, 89
9th Nov 2022 / Brigitte Dorner / CERIS MeetingDetection of biological
Titelmasterformat durchtoxins:
KlickenAbearbeiten
challenge
Toxins are active in the absence of the producing organism and its genetic information; detection of DNA not
sufficient, protein/toxin detection necessary
Ricin / Abrin: Botulinum toxins:
RNA-N-glycosidases Neurotoxins
>> accidental intoxications >> botulism
LD50: 3 µg/kg (inhalation) LD50: 1 ng/kg (inhalation)
Saxitoxin: Staphylococcal enterotoxins:
Na+ channel blocker Superantigens
>> food intoxications >> food intoxications
LD50: 6 µg/kg (oral) LD50: 27 ng/kg (inhalation)
Dorner BG et al., (2016) Trends in Analytical Chemistry 85, 89
9th Nov 2022 / Brigitte Dorner / CERIS MeetingDetection of biological
Titelmasterformat durchtoxins:
KlickenAbearbeiten
challenge
Toxins are active in the absence of the producing organism and its genetic information; detection of DNA not
sufficient, protein/toxin detection necessary
Ricin / Abrin: Botulinum toxins:
RNA-N-glycosidases Neurotoxins
>> accidental intoxications >> botulism
LD50: 3 µg/kg (inhalation) LD50: 1 ng/kg (inhalation)
Saxitoxin: Staphylococcal enterotoxins:
Na+ channel blocker Superantigens
>> food intoxications >> food intoxications
LD50: 6 µg/kg (oral) LD50: 27 ng/kg (inhalation)
Dorner BG et al., (2016) Trends in Analytical Chemistry 85, 89
Very high toxicity poses per se a challenge for detection technology; LOD: few pg/mL
9th Nov 2022 / Brigitte Dorner / CERIS MeetingDetection of biological
Titelmasterformat durchtoxins:
KlickenAbearbeiten
challenge
Toxins are active in the absence of the producing organism and its genetic information; detection of DNA not
sufficient, protein/toxin detection necessary
Ricin / Abrin: Botulinum toxins:
RNA-N-glycosidases Neurotoxins
>> accidental intoxications >> botulism
LD50: 3 µg/kg (inhalation) LD50: 1 ng/kg (inhalation)
Saxitoxin: Staphylococcal enterotoxins:
Na+ channel blocker Superantigens
>> food intoxications >> food intoxications
LD50: 6 µg/kg (oral) LD50: 27 ng/kg (inhalation)
Dorner BG et al., (2016) Trends in Analytical Chemistry 85, 89
Very high toxicity poses per se a challenge for detection technology; LOD: few pg/mL
Toxins are rapidly metabolized in the human body limiting the time window for detection in clinical samples
9th Nov 2022 / Brigitte Dorner / CERIS MeetingDetection of biological
Titelmasterformat durchtoxins:
KlickenAbearbeiten
challenge
Toxins are active in the absence of the producing organism and its genetic information; detection of DNA not
sufficient, protein/toxin detection necessary
Ricin / Abrin: Botulinum toxins:
RNA-N-glycosidases Neurotoxins
>> accidental intoxications >> botulism
LD50: 3 µg/kg (inhalation) LD50: 1 ng/kg (inhalation)
Saxitoxin: Staphylococcal enterotoxins:
Na+ channel blocker Superantigens
>> food intoxications >> food intoxications
LD50: 6 µg/kg (oral) LD50: 27 ng/kg (inhalation)
Dorner BG et al., (2016) Trends in Analytical Chemistry 85, 89
Very high toxicity poses per se a challenge for detection technology; LOD: few pg/mL
Toxins are rapidly metabolized in the human body limiting the time window for detection in clinical samples
Toxins are produced in different variants which might differ in characteristics; challenge to detect and – if necessary
– to differentiate toxin variants
9th Nov 2022 / Brigitte Dorner / CERIS MeetingFrom EQuATox
Titelmasterformat to Klicken
durch EuroBioTox
bearbeiten
35 institutions from 20 countries
2012 – 2014
EU contribution: 1,338,634 EUR
Main result and impact:
Snapshot on biological toxin detection
capabilities (status quo)
Identification of gaps and technical limitations
9th Nov 2022 / Brigitte Dorner / CERIS MeetingFrom EQuATox
Titelmasterformat to Klicken
durch EuroBioTox
bearbeiten
35 institutions from 20 countries 63 institutions from 23 countries
2012 – 2014 06/2017 – 05/2023
EU contribution: 1,338,634 EUR EU contribution: 7,998,747 EUR
Total cost: 9,526,721 EUR
Main result and impact: Main objectives:
Snapshot on biological toxin detection Increase detection capabilities
capabilities (status quo) to an advanced technical level
Identification of gaps and technical limitations Pan-European network of competence
9th Nov 2022 / Brigitte Dorner / CERIS MeetingFrom EQuATox
Titelmasterformat to Klicken
durch EuroBioTox
bearbeiten
35 institutions from 20 countries 63 institutions from 23 countries
2012 – 2014 06/2017 – 05/2023
EU contribution: 1,338,634 EUR EU contribution: 7,998,747 EUR
Total cost: 9,526,721 EUR
Main result and impact: Main objectives:
Snapshot on biological toxin detection Increase detection capabilities
capabilities (status quo) to an advanced technical level
Identification of gaps and technical limitations Pan-European network of competence
Establishment of a comprehensive mechanism to increase quality assurance in the field
(certified reference materials, repository of tools, training courses, proficiency tests)
GOALS
Evaluation and refinement of measurement procedures
Evaluate potential replacement methods for animal experiments (BoNT)
Coordination of laboratories, industrial partners and end-users working on biological toxins in the EU to
spread know-how from experts to practitioners
9th Nov 2022 / Brigitte Dorner / CERIS MeetingProject
Titelmasterformat partners
durch Klicken bearbeiten
13 core partners (beneficiaries)
50 network partners
63 expert institutions from 23 countries
10 work packages
www.EuroBioTox.eu
9th Nov 2022 / Brigitte Dorner / CERIS MeetingEssential pieces
Titelmasterformat durchofKlicken
the puzzle
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Certified Repository
reference of tools &
materials reagents
WP1 WP2
WP3 WP5
Proficiency Training
tests courses
9th Nov 2022 / Brigitte Dorner / CERIS MeetingDevelopment & productiondurch
Titelmasterformat of certified
Klicken reference
bearbeitenmaterials
(WP1)
Candidate CRMs Candidate CRMs
purified from natural sources produced by recombinant techniques
10,500 vials (ricin) 10,070 vials (BoNT/A)
240 vials (abrin) 1,500 vials (BoNT/B)
1,500 vials (SEB)
9th Nov 2022 / Brigitte Dorner / CERIS MeetingDevelopment & productiondurch
Titelmasterformat of certified
Klicken reference
bearbeitenmaterials
(WP1)
Candidate CRMs Candidate CRMs
purified from natural sources produced by recombinant techniques
10,500 vials (ricin) 10,070 vials (BoNT/A)
240 vials (abrin) 1,500 vials (BoNT/B)
CRMs = „Anchor points for precise analytics“ 1,500 vials (SEB)
Decision makers rely on correct and reliable
laboratory data in order to make appropriate and
timely decisions (e.g. amount, purity and activity of
biotoxins)
9th Nov 2022 / Brigitte Dorner / CERIS MeetingDevelopment & productiondurch
Titelmasterformat of certified
Klicken reference
bearbeitenmaterials
(WP1)
Purity / Identity Concentration
SDS-PAGE, Amino acid analysis/Photometry
Capillary Gel Electrophoresis, • AAA: Hydrolysis conditions,
LC-MS/MS and MALDI-TOF MS, number of amino acids
Homogeneity / stability
ELISA, Western blot • Value assignment
• Main component High-throughput method
• Identification of impurities with sufficient precision
Biological activity • Short term stability (weeks):
• Quantification of impurities
In vivo / ex vivo methods dispatch conditions
• Molecular weight
In vitro method • Long term stability (years):
• Comparison with other toxin
• Activity of all toxin chains: storage conditions
preparations
Receptor binding
• Correct folding
Enzymatic activity
• Identification of post-trans-lational
• Binding of target molecule
modifications
• Value assignment
Zeleny R, Rummel A, Jansson D, Dorner BG (2019). ACS Symposium Series #1339. https://edoc.rki.de/handle/176904/6290
9th Nov 2022 / Brigitte Dorner / CERIS MeetingDevelopment & productiondurch
Titelmasterformat of certified
Klicken reference
bearbeitenmaterials
(WP1)
Purity / Identity Concentration
SDS-PAGE, Amino acid analysis/Photometry
Capillary Gel Electrophoresis, • AAA: Hydrolysis conditions,
LC-MS/MS and MALDI-TOF MS, number of amino acids
Homogeneity / stability
ELISA, Western blot • Value assignment
• Main component High-throughput method
• Identification of impurities with sufficient precision
Biological activity • Short term stability (weeks):
• Quantification of impurities
In vivo / ex vivo methods dispatch conditions
• Molecular weight
In vitro method • Long term stability (years):
• Comparison with other toxin
• Activity of all toxin chains: storage conditions
preparations
Receptor binding
• Correct folding
Enzymatic activity
• Identification of post-trans-lational
• Binding of target molecule
modifications
• Value assignment
First CRM (SEB) was released in Jan 2022;
CRMs for ricin, abrin, BoNT/A and BoNT/B are expected to be released in 2023
Zeleny R, Rummel A, Jansson D, Dorner BG (2019). ACS Symposium Series #1339. https://edoc.rki.de/handle/176904/6290
9th Nov 2022 / Brigitte Dorner / CERIS MeetingRepository of tools
Titelmasterformat andKlicken
durch reagents (WP2)
bearbeiten
WP2 Highly specific, proprietary monoclonal antibodies
Panel of bacterial supernatants and recombinant toxins representing toxin
subtypes
Peptide standards for MS (AQUA peptides), multiplex lateral flow assays
Real sample materials
More than 190 shipments of materials executed within the network
9th Nov 2022 / Brigitte Dorner / CERIS MeetingRepository of tools
Titelmasterformat andKlicken
durch reagents (WP2)
bearbeiten
Training courses (WP5)
WP2 Highly specific, proprietary monoclonal antibodies
Panel of bacterial supernatants and recombinant toxins representing toxin
subtypes
Peptide standards for MS (AQUA peptides), multiplex lateral flow assays
Real sample materials
More than 190 shipments of materials executed within the network
WP5
19 different training courses tailored to the different toxins and methods
Immunological, spectrometric, functional, chromatographic methods
Basic or advanced training levels
On-site courses and remote training courses
33 laboratories trained
9th Nov 2022 / Brigitte Dorner / CERIS MeetingEstablishment
Titelmasterformat of a bearbeiten
durch Klicken
European proficiency testing scheme (WP3)
Generation & characterisation of
toxin reference material
combining the expertise from
EU labs
Setting up PT schemes
including real sample materials
(test for sample preparation
strategies)
Method 1 Evaluation of results:
Method 2
Method 3 - Comparison of methods used
Method 4
Method 5 (qual./quant./funct. analysis)
Method 6
Method 7
- Performance of laboratories
Method 8
- Identification of gaps and best practices
9th Nov 2022 / Brigitte Dorner / CERIS MeetingEstablishment
Titelmasterformat of a bearbeiten
durch Klicken
European proficiency testing scheme (WP3)
Generation & characterisation of
toxin reference material Ricin Abrin
combining the expertise from
EU labs
BoNTs SEs
Setting up PT schemes
including real sample materials
(test for sample preparation On-site-
STX
strategies) detection
11 PTs
Method 1 Evaluation of results:
Method 2
Method 3 - Comparison of methods used
Method 4
Method 5 (qual./quant./funct. analysis)
Method 6
Method 7
- Performance of laboratories
Method 8
- Identification of gaps and best practices
9th Nov 2022 / Brigitte Dorner / CERIS MeetingEstablishment
Titelmasterformat of a bearbeiten
durch Klicken
European proficiency testing scheme (WP3)
Generation & characterisation of
toxin reference material Ricin Abrin
combining the expertise from
EU labs
BoNTs SEs
Setting up PT schemes
including real sample materials
(test for sample preparation On-site-
STX
strategies) detection
11 PTs
Method 1 Evaluation of results:
Method 2
Method 3 - Comparison of methods used Highly relevant insights into
Method 4
(qual./quant./funct. analysis) actual detection capabilities
Method 5
Method 6
- Performance of laboratories and the potential for further
Method 7
Method 8
- Identification of gaps and best practices technical improvement
9th Nov 2022 / Brigitte Dorner / CERIS MeetingEstablishment
Titelmasterformat of a bearbeiten
durch Klicken
European proficiency testing scheme (WP3)
Generation & characterisation of
toxin reference material Ricin Abrin
combining the expertise from
EU labs
BoNTs SEs
Setting up PT schemes
including real sample materials
(test for sample preparation On-site-
STX
strategies) detection
11 PTs
Method 1 Evaluation of results:
Method 2
Method 3
Current status
- Comparison of methods used Highly relevant insights into
Method 4
(qual./quant./funct. analysis) actual detection capabilities
Clearly, more time and effort has to be invested to further increase biotoxin detection
Method 5
and the potential for further
Method 6
- Performance of laboratories
Method 7
capabilities in EU Member States beyond the current status technical improvement
Method 8
- Identification of gaps and best practices
9th Nov 2022 / Brigitte Dorner / CERIS MeetingAdditional EuroBioTox
Titelmasterformat highlights
durch Klicken bearbeiten
WP4 – Quality management and SOPs
-Surveys
-QM documents
-Method SOPs
-Validation SOP
9th Nov 2022 / Brigitte Dorner / CERIS MeetingAdditional EuroBioTox
Titelmasterformat highlights
durch Klicken bearbeiten
WP4 – Quality management and SOPs WP6 – In-situ detection and forensics
-Surveys -Guidelines, work-
-QM documents shop and movie for
-Method SOPs first responders
-Validation SOP -Forensic database
9th Nov 2022 / Brigitte Dorner / CERIS MeetingAdditional EuroBioTox
Titelmasterformat highlights
durch Klicken bearbeiten
WP4 – Quality management and SOPs WP6 – In-situ detection and forensics
-Surveys -Guidelines, work-
-QM documents shop and movie for
-Method SOPs first responders
-Validation SOP -Forensic database
WP7 – Animal replacement methods
-Evaluation of 5 potential
replacement methods
9th Nov 2022 / Brigitte Dorner / CERIS MeetingAdditional EuroBioTox
Titelmasterformat highlights
durch Klicken bearbeiten
WP4 – Quality management and SOPs WP6 – In-situ detection and forensics
-Surveys -Guidelines, work-
-QM documents shop and movie for
-Method SOPs first responders
-Validation SOP -Forensic database
WP7 – Animal replacement methods WP8 – Dissemination & communication
-Project website
(>35,000 visitors)
-3 scientific papers
> 50 oral presentations
-6 posters
-2 movies
-Evaluation of 5 potential -1 brochure
replacement methods -e-learning materials
9th Nov 2022 / Brigitte Dorner / CERIS MeetingImpact and
Titelmasterformat benefits
durch Klickenfor
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EuroBioTox participants
Confidence building, development of mutual trust
Strengthening laboratory capabilities
Harmonization of technical approaches
9th Nov 2022 / Brigitte Dorner / CERIS MeetingImpact and
Titelmasterformat benefits
durch Klickenfor
bearbeiten
EuroBioTox participants
Confidence building, development of mutual trust
Strengthening laboratory capabilities
Harmonization of technical approaches
Enable and/or maintain accreditation
Enable 3R activities (BoNT)
9th Nov 2022 / Brigitte Dorner / CERIS MeetingImpact and
Titelmasterformat benefits
durch Klickenfor
bearbeiten
EuroBioTox participants
Confidence building, development of mutual trust
Strengthening laboratory capabilities
Harmonization of technical approaches
Enable and/or maintain accreditation
Enable 3R activities (BoNT)
Liaison with relevant international organisations (OPCW)
9th Nov 2022 / Brigitte Dorner / CERIS MeetingImpact and
Titelmasterformat benefits
durch Klickenfor
bearbeiten
EuroBioTox participants
Confidence building, development of mutual trust
Strengthening laboratory capabilities
Harmonization of technical approaches
Enable and/or maintain accreditation
Enable 3R activities (BoNT)
Liaison with relevant international organisations (OPCW)
Spreading of excellence to end users
Improved preparedness and response planning
9th Nov 2022 / Brigitte Dorner / CERIS MeetingFuture of EuroBioTox
Titelmasterformat beyond
durch Klicken 2023
bearbeiten
EuroBioTox contributes to minimize potential health and security threats in EU and increases resilience of civil
society by sound capacity building (only until end of the project)
9th Nov 2022 / Brigitte Dorner / CERIS MeetingFuture of EuroBioTox
Titelmasterformat beyond
durch Klicken 2023
bearbeiten
EuroBioTox contributes to minimize potential health and security threats in EU and increases resilience of civil
society by sound capacity building (only until end of the project)
A long term perspective is needed how to further develop the network based on the status quo reached under
EuroBioTox
9th Nov 2022 / Brigitte Dorner / CERIS MeetingFuture of EuroBioTox
Titelmasterformat beyond
durch Klicken 2023
bearbeiten
EuroBioTox contributes to minimize potential health and security threats in EU and increases resilience of civil
society by sound capacity building (only until end of the project)
A long term perspective is needed how to further develop the network based on the status quo reached under
EuroBioTox
Need for an “EU reference laboratory for security-relevant biotoxins” Food safety networks
supporting tasks relevant in the security sector, complementary to existing
networks
Communicable diseases networks
9th Nov 2022 / Brigitte Dorner / CERIS MeetingFuture of EuroBioTox
Titelmasterformat beyond
durch Klicken 2023
bearbeiten
EuroBioTox contributes to minimize potential health and security threats in EU and increases resilience of civil
society by sound capacity building (only until end of the project)
A long term perspective is needed how to further develop the network based on the status quo reached under
EuroBioTox
Need for an “EU reference laboratory for security-relevant biotoxins” Food safety networks
supporting tasks relevant in the security sector, complementary to existing
networks
If resources are not allocated for future actions, gaps will remain or even
increase!
Central need: Repository function, training, regular proficiency testing
Communicable diseases networks
Stabilization of interaction between expert labs, sustainability of technical
improvement
Very specialized expertise needed not available in many EU countries on all
relevant biotoxins >> burden sharing necessary; support of Eastern European
countries necessary
Coordinated action is needed in a cross-border event related to biotoxins
9th Nov 2022 / Brigitte Dorner / CERIS MeetingThank you for
Titelmasterformat yourKlicken
durch attention!
bearbeiten
RKI, DE: S. Worbs, B. Kampa, M. Skiba, D. Stern, FUNDING
M.B. Dorner, J. Millert, A. Kowalczyk,
E. Schlereth, H. Ranisch, B.G. Dorner (coordination)
EC-JRC, BE: K. Busschots, R. Zeleny
Grant Agreement No: 740189
Sciensano, BE: J. Masquelier, T. van Nieuwenhuysen,
EUROPEAN COMMISSION
J. van Loco
Co-funding by Swiss SERI
UH Verifin, FI: A. Puustinen, M. Kjellberg, P. Vanninen
Inst. Pasteur, FR: C. Rasetti-Escargueil, M. Popoff, E. Lemichez
CEA, FR: A.-S. Mierzala, H. Volland, F. Becher,
S. Simon
ANSES, FR: B. Boran, Y. Nia, J.-A. Hennekinne www.EuroBioTox.eu
Toxogen, DE: J. Weisemann, A. Rummel Contact: DornerB@rki.de
FOI, SE: T. Bergström, J. Naslund, D. Jansson
Spiez Lab, CH: M. Avondet, C. Müller, M. Wittwer
ChemStat, CH: W. Luginbühl THANKS TO ALL
ZHAW, CH: R. Josuran, C. Zaborosch, S. Gerber NETWORK PARTNERS
Queen’s Univ., UK: L. Burns, K. Campbell FOR THEIR SUPPORT
9th Nov 2022 / Brigitte Dorner / CERIS MeetingYou can also read
