Aspekte der Ernährung in der Schmerztherapie - Alexander Dassel PHYSIO FRANKFURT 2018
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Aspekte der Ernährung
in der Schmerztherapie
Alexander Dassel
© PHYSIO FRANKFURT 2018
Pro- & Anti-Inflammatorische Lebensmittel
■ Lebensmittel unterschiedlicher Zusammensetzung
induzieren im Körper biochemische Prozesse.
■ Beim Abbau von Proteinen, Kohlenhydraten, Lipiden und
anderen Nahrungsbestandteilen entstehen
Stoffwechselprodukte, die Entzündungsprozesse
anregen, aufrechterhalten oder hemmen können.
© PHYSIO FRANKFURT 2018
demonstrates that the effect of the diet is greater than a control
OPEN
treatment for some outcomes. 14 Bax G, Fagherazzi C, Piarulli F, Nicolu
Citation: Nutrition & Diabetes (2015) 5, e158; doi:10.1038/nutd.2015.8
Michigan Neuropathy Screening Instrum
Nutrition studies are particularly important given that drugs
www.nature.com/nutd using the vibratory and thermal percepti
used to manage blood glucose have significant side effects, and 904–905.
drugs used for diabetic nerve pain typically offer only limited 15 Bril V. NIS-LL: the primary measurement
benefit. Further
ORIGINAL studies might eliminate the confounding factor of
ARTICLE betic peripheral neuropathy. Eur Neurol 1
vitamin B12 status by including vitamin B12 pretreatment or an 16 Sun Y, Lai MS, Lu CJ. Effectiveness of vita
A dietary intervention for chronic diabetic neuropathy
alternative control, such as a subclinical dose of B12. A trial testing tematic review of clinical controlled trials
diet, exercise and vitamin B12 in combination might be a useful 17 Calvet JH, Dupin J, Winiecki H, Schwarz PE
pain: a randomized controlled pilot study
means of assessing the effects of a more intensive intervention in through a quick, simple and non inva
outpatient clinic. Exp Clin Endocrinol Diab
this otherwise
1 intractable
1 1and debilitating
2 chronic
3 disease.
AE Bunner , CL Wells , J Gonzales , U Agarwal , E Bayat and ND Barnard 1,4
18 Yajnik CS, Kantikar VV, Pande AJ, Deslype
sudomotor function for screening of diab
2012: 103714.
CONFLICT
BACKGROUND: OF Diabetic
INTEREST neuropathy is a common and often debilitating condition for which available treatments are limited.
19 Casellini CM, Parson HK,
Because a low-fat plant-based diet hasCitation: Nutrition
been shown & Diabetes
to improve glycemic (2015)
control 5, ine158; doi:10.1038/nutd.2015.8
individuals with type 2 diabetes, weRichardson MS, N
The authors declare no conflict of interest. invasive tool for detecting diabetic small
hypothesized that such a diet would reduce painful symptoms of diabetic neuropathy.
METHODS: In this 20-week pilot study,www.nature.com/nutd
individuals with type 2 diabetes and painful diabetic neuropathy function.were
Diabetes
randomlyTechnol 2013; 15:
Ther to
assigned
two groups. The intervention group was asked to follow a low-fat, plant-based diet, with weekly 20 Kamper SJ,support
classes for MaherinCG, Mackay
following theG. Globa
■ 20 Wochen Interventionszeit
ACKNOWLEDGEMENTS
prescribed diet, and to take a vitamin B12 supplement. The control group was asked to take the strengths same vitamin
andB12 supplement,
weaknesses andbut
considerat
Wereceived
gratefullynoacknowledge
other intervention.
ImpetoAtMedical
baseline,formidpoint and 20device,
the Sudoscan weeks,Drclinical, laboratory and questionnaire
Paul Poppen 17: 163–170.data were collected.
E andQuestionnaires included an analog ‘worst pain’ scale, Michigan Neuropathy Screening Instrument,
Dr Richard Holubkov for statistical analysis and advice, Dr Chengyuan Li for 21 Graham global
C, impression
Bond SS, scale, Short MM, Co
Gerkovich
Form McGill Pain Questionnaire, Neuropathy Total Symptom Score, a weekly pain diary and Norfolk Quality of Life Questionnaire.
■ Typ 2-Diabetes und schmerzhafte diabetische Neuropathie
contributions to study design, Rosendo Flores and Francesca Valente for contribu- tionnaire in the assessment of cancer p
ntervention for chronic diabetic neuropathy
RESULTS: After 20 weeks, body weight change with the intervention was − 6.4 kg (95% confidence interval (CI) − 9.4 to − 3.4,
tions 1980; 8: 377–387.
Poto datain acquisition,
0.001) an effect sizeand Susan
analysis. Levin, RD, for
Electrochemical skincritical comments
conductance in the onfoottheimproved by an average of 12.4 microseimens
manuscript. 22 Kremer E, Atkinson JH Jr. Pain measurem
(95% CI 1.2–23.6, P = 0.03) with the intervention in an effect size analysis. The between-group difference in change in pain, as
measured by the McGill pain questionnaire, was − 8.2 points (95% CI − 16.1 to − 0.3, P = 0.04). dimension of the McGill Pain Questionna
■ Low-fat und pflanzenbasierte Diät mit Vitamin B12-Ergänzung im
domized controlled pilot study
Michigan Neuropathy Screening
Instrument questionnaire score change was − 1.6 points (95% CI − 3.0 to − 0.2, P = 0.03). Pain 1981; 11: 93–100.
Vergleich zu ausschließlicher Vitamin B12-Gabe.
AUTHOR
CONCLUSIONS:CONTRIBUTIONS
Improvements were seen in some clinical and pain measures. This pilot study
plant-based diet intervention, including weekly support classes, for treating painful diabetic neuropathy.
23 Vinik EJ, Hayes
suggests RP, Oglesby
the potential value ofA,a Bastyr E
development and validation of the Norfo
All authors2 contributed to data acquisition. AEB 1,4 and NDB wrote the manuscript.
Gonzales1, U AgarwalNutrition Bayat3(2015)
, E& Diabetes and 5,ND
e158;Barnard
doi:10.1038/nutd.2015.8; published online 26 May 2015 perception of the effects of diabetes and
CLW and EB reviewed/edited the manuscript, and EB contributed to discussion. Ther 2005; 7: 497–508.
■ Durchschnittliche Gewichtsabnahme (Diät-Gruppe): 6,4 kg 24 Vinik EJ, Paulson JF, Ford-Molvik SL, Vinik A
life (QOL-DN) identifies the same factors
tic neuropathy is a common and often debilitating condition for which
REFERENCES
BACKGROUND availablediet
Two uncontrolled treatments
intervention
discriminates are
studies limited.
showed
different promising
levels of neuropath
10,11
t-based diet hasDiabetic results in individuals with diabetic neuropathy. We therefore
1been shown
Kles peripheral
KA, to improve
neuropathy
Vinik AI. occursglycemic
in up to 60%control
■ Signifikante Schmerz- und Neuropathiesymptom-Reduktion in individuals
of individuals
1 Pathophysiology and treatment of diabetic peripheral hypothesized
with
neuro-
that
type
a
22:diabetes,
plant-based
1075–1086. we
dietary intervention can reduce
with type 2 diabetes and is associated with significant morbidity,
h a diet would reduce pathy: painful
the case symptoms
for diabetic of diabetic
neurovascular neuropathy.
function
including gait disturbances, amputations, anxiety, depression and as an essential component. 25 Tanenberg
diabetic neuropathy pain and conducted RJ, Irving GA, Rissercon-
a randomized, RC, Ah
The2:
2006; trolled, pilot study to were Duloxetine,
test this hypothesis.pregabalin,
This study was andintended
duloxetine p
Curr Diabetes
week pilot study,reduced
individuals
quality of Rev
with type
life.2,3 2131–145.
diabetes
condition andwith
manifests painful
damagediabetic
to neuropathy
to investigate the efficacy of
randomly
this approach
assigned
and
to
the suitabilityinofpatien
2 Wu
the SC, Wrobel
terminal branches JS,ofArmstrong
peripheral DG.nervesAssessing the first
and usually impact of pharmacologic
affects inter- neuropathic pain management
ention group was asked
small fibers to
vention
follow
that
on thearequality a low-fat,
responsible plant-based
© PHYSIO
of lifeforin translating
diabetic
diet,
FRANKFURT
pain, light
peripheral
with weekly
touch
neuropathic 2018
the
painoverallclasses
and method,
for support
fibro- permitting
intrials
larger
gabapentin: following
an to follow.the
open-label, The study
randomized,■ Mehrfach ungesättigte Omega-3-Fettsäure, tgl. 2-10 g über
3-4 Monate
■ Patienten mit rheumatoider Arthritis oder Gelenkschmerzen
nach Darmentzündungen oder postmenopausal
■ Signifikante Verbesserungen in den Bereichen subjektiver
Gelenkschmerz, Zeit der morgendlichen Steifigkeit, Anzahl
schmerzhafter Sehnenansätze, NSAR-Dosis
© PHYSIO FRANKFURT 2018Original Article
Meta-Analysis of the Related Nutritional Supplements
Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment
of Osteoarthritis of the Knee Hindawi Publishing Corporation
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 528403, 12 pages
Sarah Brien,1 Phil Prescott,2 and George Lewith1 doi:10.1093/ecam/nep045
1 Department of Primary Medical Care, University of Southampton, Aldermoor Health Centre, Aldermoor Close, Southampton,
Hampshire, SO16 5ST, UK
2 School of Mathematics, University of Southampton, Southampton, Hampshire, SO16 5ST, UK
Correspondence should be addressed to Sarah Brien, s.brien@southampton.ac.uk
Received 24 October 2008; Accepted 23 April 2009
■ Knie-Osteoarthritis, tägliche Einnahme Original ~3 gArticle
Dimethyl
Copyright © 2011 Sarah Brien et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sulfoxide (DMSO)
Dimethyl sulphoxide und
and methylsulfonylmethaneMethylsulfonylmethane Meta-Analysis (MSM)
are two related nutritional supplements used for symptomatic
osteoarthritis (OA). We conducted a meta-analysis to evaluate their efficacy of the relief of
in reducing pain associated with OA. Randomized or Relate
quasi-randomized controlled trials (RCTs), identified by systematic electronic searches, citation tracking and searches of clinical
Dimethyl Sulfoxide and Me
trial registries, assessing these supplements in osteoarthritis of any joint were considered for inclusion. Meta-analysis, based on
■ Indifferente Aussagen
difference in mean pain related outcomes between treatment and comparator groups, was carried out based on a random effect
model. Seven potential trials were identified of which three RCTs, two DMSO and one MSM (total N = 326 patients) were
of Osteoarthritis of the Kn
eligible for inclusion. All three trials were considered high methodological quality. A significant degree of heterogeneity (χ 2 = 6.28,
P = .043) was revealed. Two studies demonstrated statistically significant (but not clinically relevant) reduction in pain compared
with controls; with one showing no group difference. The meta-analysis confirmed a non significant reduction of pain on visual
■ In Teilen signifikante aber klinisch irrelevante
analogue scale of 6.34 mm (SE = 3.49, 95% CI, −0.49, 13.17). The overall effect size of 1.82 was neither statistically nor clinically
significant. Current evidence suggests DMSO and MSM are not clinically effective in the reduction of pain in the treatment of
OA. No definitive conclusions can currently be drawn from the data due to the mixed findings and the use of inadequate dosing
Verbesserungen der Schmerzintensität.Sarah Brien, Phil Prescott,2 and
periods. 1
1 Department
of Primary Medical Care, Univers
1. Introduction Hampshire, SO16 5ST, UK
the general population with a reported prevalence of up to
2 School of Mathematics, University of Southam
90% [8, 9].
© PHYSIO FRANKFURT 2018
Osteoarthritis (OA) is the most common of all joint disorders Two nutritional supplements, dimethyl sulfoxideISSN: 1040-8398 (Print) 1549-7852 (Online) Journal homepage: http://www.tandfonline.com/loi/bfsn20
Dairy products and inflammation: A review of the
clinical evidence
Alessandra Bordoni, Francesca Danesi, Dominique Dardevet, Didier Dupont,
Aida S. Fernandez, Doreen Gille, Claudia Nunes dos Santos, Paula Pinto,
Roberta Re, Didier Rémond, Danit R. Shahar & Guy Vergères
CRITICAL
To REVIEWS
cite this article: IN FOOD SCIENCE
Alessandra Bordoni,AND NUTRITION
Francesca Danesi, Dominique Dardevet, Didier Dupont,
2017,S.VOL.
Aida 57, NO. Doreen
Fernandez, 12, 2497–2525
Gille, Claudia Nunes dos Santos, Paula Pinto, Roberta Re, Didier
Rémond, Danit R. Shahar & Guy Vergères (2017) Dairy products and inflammation: A review of
http://dx.doi.org/10.1080/10408398.2014.967385
the clinical evidence, Critical Reviews in Food Science and Nutrition, 57:12, 2497-2525, DOI:
10.1080/10408398.2014.967385
To link to this article: https://doi.org/10.1080/10408398.2014.967385
■ Milchprodukte, insbesondere fermentierte Produkte,
Dairy
habenproducts
entzündungshemmende and inflammation: A review speziell
Eigenschaften, of the clinical e
beilicense
Patienten mit
by Taylor & Francis
a
Stoffwechselstörungen
© 2017 The Author(s). Published with
Group, LLC©
View supplementary material
a b,c d
Alessandra
Alessandra Bordoni , Francesca
Bordoni, Francesca Danesi,
Dominique Dardevet, Didier Dupont, Aida
Danesi , Dominique Dardevet , Didier Dupont ,
g,h g,i e b,c
Claudia Nunes
Fernandez, Doreendos
Gille,Santos
Claudia Nunes , Paula Pinto , Roberta Re , Didier R e
! mond , Danit
■a ZuRémond,
fermentierten Produkten zählen vorwiegend
dos Santos, Paula Pinto, Roberta Re, Didier
Danit Shahar, Guy Vergères
Department of Agri-Food Sciences and Technologies, University of Bologna, Bologna, Italy; bINRA, UM
Sauermilch,
Accepted
Ferrand, France; Joghurt,
c version
authorClermont posted online: Kefir,
Universit 19 Buttermilch
!e, Universit!e d’Auvergne,
Submit
und
Unit
your article to this !e deKäse.
journal Nutrition Humaine, Clermont-F
Aug 2015.
Science & Technology of Milk and Egg Products, Rennes, France; eDepartment of Human Nutrition, Lea
Published online: 19 Aug 2015.
f
Kingdom; Agroscope, Federal Department of Economic Affairs, Education and Research EAER, Berne, S
Article views: 40876 View related articles
Biol!ogica, Universidade Nova de Lisboa, Lisbon, Portugal; hInsituto de Biologia Experimental e Tecnol!o
j
Insituto Polit!ecnico de Santar!em, ©Santar!e m Portugal;
PHYSIO FRANKFURT 2018
The S. Daniel Abraham International Center for HLakhan et al. Nutrition Journal (2015) 14:50
DOI 10.1186/s12937-015-0038-8
RESEARCH Open Access
Zingiberaceae extracts for pain: a systematic
review and meta-analysis
Shaheen E. Lakhan1*, Christopher T. Ford1,2 and Deborah Tepper3
Abstract
Auszüge
■ Background: Membersaus Ingwergewächsen
of the family als Javanese
Zingiberaceae including turmeric, ginger, Nahrungsbestandteil,
ginger, and galangal have
been used for centuries in traditional medicine. Preclinical studies of Zingiberaceae extracts have shown analgesic
>500Thismg
properties. täglich
study aims to systematically review and meta-analyze whether extracts from Zingiberaceae are
clinically effective hypoalgesic agents.
Methods: Literature was screened from electronic databases using the key words Zingiberaceae AND pain OR visual
■ Bekannteste Vertreter: Ingwer und Curcuma
analogue score (VAS) to identify randomized trials. From this search, 18 studies were identified, and of these, 8
randomized, double-blinded, placebo-controlled trials were found that measured pain by VAS for inclusion in the
meta-analysis.
Results: Findings indicated significant efficacy of Zingiberaceae extracts in reducing subjective chronic pain (SMD − 0.67;
95 % CI − 1.13 to − 0.21; P = 0.004). A linear dose-effect relationship was apparent between studies (R2 = 0.71). All studies
■ Ähnlich potent wie anti-entzündliche Medikamente
included in the systematic review reported a good safety profile for extracts, without the renal risks associated with
non-steroidal anti-inflammatory drugs, and with similar effectiveness.
Conclusion: Our findings indicated that Zingiberaceae extracts are clinically effective hypoalgesic agents and the
available data show a better safety profile than non-steroidal anti-inflammatory drugs. However, both non-steroidal
anti-inflammatory drugs and Zingiberaceae have been associated with a heightened bleeding risk, and there have been
© PHYSIO
no comparator trials of this risk. Further clinical studies FRANKFURT
are recommended to 2018
identify the most effective type ofSee discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/320325996
Dietary supplements for treating
osteoarthritis: a systematic review and meta-
analysis
Downloaded from http://bjsm.bmj.com/ on October 10, 2017 - Published by group.bmj.com
BJSM Online First, published on October 10, 2017 as 10.1136/bjsports-2016-097333
Review
Dietary supplements
Article in British for Medicine
Journal of Sports treating osteoarthritis:
· October 2017 a
systematic review and meta-analysis
DOI: 10.1136/bjsports-2016-097333
Xiaoqian Liu,1,2 Gustavo C Machado,3 Jillian P Eyles,1,2,4 Varshini Ravi,1,2
David J Hunter1,2
CITATIONS READS
ional material is ABSTRACT knee OA was recently ranked as the 11th highest
d online only. To view 2
Objective To investigate the efficacy and safety of 327
contributor to global disability,3 with enormous
sit the journal online
dietary supplements for patients with osteoarthritis. economic burden. Costs are estimated between
■ Glucosamine und Chondroitin haben aus klinischer Sicht
x.doi.org/10.1136/
2016-097333). Design An intervention systematic review with random 0.25% and 0.50% of a country’s gross domestic
effects meta-analysis and meta-regression. product, and the mean annual incremental direct
keinen wichtigen Effekt auf Osteoarthritis
ment of Rheumatology,
rth Shore Hospital, St
, Australia
5 authors,
Data including:
sources MEDLINE, EMBASE, Cochrane Register
of Controlled Trials, Allied and Complementary Medicine
and indirect costs are nearly US$7000 per person
with OA.4
of Bone and Joint and Cumulative Index to Nursing and Allied Health Paracetamol and non-steroidal anti-inflammatory
, The Kolling Institute, Literature wereXiaoqian
searched from Liuinception to April 2017. drugs (NSAIDs) are currently endorsedGustavo Carvalho Machado
by clinical
5–7
ersity of Sydney, Study eligibility criteria Randomised controlled trials guidelines to treat OA, but emerging evidence
New South Wales,
■ Weihrauch, Pinienrindenextrakt und Curcuma haben
Medical School, The
comparing oralUniversity
supplements with
or knee osteoarthritis.
of placebo
Sydney for hand, hip has challenged this recommendation
the potential for adverse events.
University
and revealed
8 9
This new
of Sydney
Results Of 205supplements 31 CITATIONS evidence could potentially increase42 309 CITATIONS
nstitute for Global
offensichtlich größere Effekte
PUBLICATIONS investigated in 69 eligible
he University of Sydney, studies, 7 (collagen hydrolysate, passion fruit peel
New South Wales,
PUBLICATIONS
public interest
in the benefits of alternative treatments. Currently
extract, Curcuma longa extract, Boswellia serrata extract, 69% of patients with OA take some form of dietary
curcumin, pycnogenolSEEand PROFILE
L-carnitine) demonstrated supplements for their condition.10 They SEEare
PROFILE
regu-
ment of Physiotherapy,
Medical School, Royal large (effect size >0.80) and clinically important larly used by a wide range of consumers with
ore Hospital, Sydney, effects for pain reduction at short term. Another musculoskeletal ailments and often used along-
th Wales, Australia six (undenatured type II collagen, avocado soybean side or as an alternative to first-line interventions
unsaponifiables,Jillian Eyles
methylsulfonylmethane, diacerein, David Hunter
such as exercise. This has driven expenditures for
ondence to glucosamine and chondroitin) revealed statistically alternative therapies to nearly equal those spent
J Hunter, Department University
significant improvements on pain, but were of unclear ©
of Sydney PHYSIO FRANKFURT
on traditional 2018therapy.
pharmacological University
11 of Sydney
Supple-er, green-lipped mussel
See discussions, extract
stats, and author profiles forand undenatured
this publication type II evidence is limited. Five supplements (un
at: https://www.researchgate.net/publication/320325996
n demonstrated clinically important effects for pain reduc- collagen, avocado/soybean unsaponifiables (A
mong eightDietary
supplements supplements
investigated atfor medium treating term. At chondroitin and diacerein) demonstrated ef
osteoarthritis:
rm follow-up, none of the included a systematic supplements review
showedand unclear meta-clinical importance, although these
ly important effects compared with placebo. The GRADE significant. Another four (vitamin E, brome
analysis
Article in British Journal of Sports Medicine · October 2017
DOI: 10.1136/bjsports-2016-097333
CITATIONS READS
2 327
5 authors, including:
Xiaoqian Liu Gustavo Carvalho Machado
University of Sydney University of Sydney
5 PUBLICATIONS 31 CITATIONS 42 PUBLICATIONS 309 CITATIONS
SEE PROFILE SEE PROFILE
Jillian Eyles David Hunter
University of Sydney University of Sydney
24 PUBLICATIONS 71 CITATIONS 690 PUBLICATIONS 16,941 CITATIONS
SEE PROFILE SEE PROFILE
Some of the authors of this publication are also working on these related projects:
OA diagnostic and prognosis models View project
Trends in hospital admission and surgery for lumbar spinal stenosis: a population-based health
© PHYSIO FRANKFURT 2018See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/320325996
Dietary supplements for treating
osteoarthritis: a systematic review and meta-
analysis
Article in British Journal of Sports Medicine · October 2017
DOI: 10.1136/bjsports-2016-097333
CITATIONS READS
2 327
5 authors, including:
Xiaoqian Liu Gustavo Carvalho Machado
University of Sydney University of Sydney
5 PUBLICATIONS 31 CITATIONS 42 PUBLICATIONS 309 CITATIONS
SEE PROFILE SEE PROFILE
Jillian Eyles David Hunter
University of Sydney University of Sydney
24 PUBLICATIONS 71 CITATIONS 690 PUBLICATIONS 16,941 CITATIONS
SEE PROFILE SEE PROFILE
Some of the authors of this publication are also working on these related projects:
OA diagnostic and prognosis models View project
Trends in hospital admission and surgery for lumbar spinal stenosis: a population-based health
© PHYSIO FRANKFURT 2018Systematic Review
Effect of Vitamin D Supplementation on Pain: A
Systematic Review and Meta-analysis
Zhenqiang Wu, MSc, Zarintaj Malihi, MSc, Alistair W Stewart, BSc, Carlene M. M. Lawes, MD,
PhD, and Robert Scragg, MD, PhD
From: University of Auckland
Background: There is conflicting evidence from previous qualitative reviews on the effect of
Epidemiology and Biostatistics vitamin D supplementation on pain.
■ Einmalgaben Objective: Vitamin
New Zealand D zwischen 1.000 und 100.000 IU
To determine with quantitative methods if vitamin D supplementation lowers pain
täglich.
Address Correspondence:
Robert Scragg, MD, PhD
University of Auckland
levels.
Epidemiology and Biostatistics Study Design: Quantitative meta-analysis of published randomized controlled trials (RCTs).
Private Bag 92019
Auckland, New Zealand 1142
■ Signifikanter Unterschied zwischen Placebo und
Setting: This meta-analysis examined all studies involving the effect of vitamin D supplementation
E-mail:
r.scragg@auckland.ac.nz on pain score.
Substitutionsgruppe:
Disclaimer: There was no
external funding in the
Method: Electronic Insources
der(Medline,
Vitamin D-Gruppe
Embase, Cochrane Central Registerist eineTrials,
of Controlled
clinical trials website, and Google scholar) were systematically searched for RCTs of vitamin D
signifikante
Conflict of interest: Each author Reduktion
preparation of this manuscript.
supplementation and von pain from chronischem Schmerz
inception of each database to October 2015. zu
certifies that he or she, or a
beobachten.
member of his or her immediate
family, has no commercial
Results: Nineteen RCTs with 3,436 participants (1,780 on vitamin D supplementation and 1,656 on
placebo) were included in the meta-analysis. For the primary outcome (mean change in pain score
association (i.e., consultancies,
stock ownership, equity interest,
from baseline to final follow-up), 8 trials with 1,222 participants on vitamin D and 1,235 on placebo
patent/licensing arrangements, reported a significantly greater mean decrease in pain score for the vitamin D group compared to
etc.) that might pose a conflict of placebo (mean difference -0.57, 95% CI: -1.00 to -0.15, P = 0.007). The effect from vitamin D was
interest in connection with the © PHYSIO
greater in patients FRANKFURT
recruited with pre-existing 2018
pain (P-value for interaction = 0.03). Fourteen studies
submitted manuscript.Osteoarthritis and Cartilage (2008) 16, 965e972
ª 2008 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
doi:10.1016/j.joca.2008.03.001
International
Cartilage
Repair
Society
Review
Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis
patients? e a meta-analysis of randomized controlled trials
R. Christensen M.Sc.y, E. M. Bartels Ph.D., D.Sc.yz, R. D. Altman M.D., Professorx,
A. Astrup M.D., Ph.D., Professork and H. Bliddal M.D., Ph.D.y*
y The Parker Institute, Musculoskeletal Statistics Unit, Frederiksberg Hospital, Denmark
z Copenhagen University Library, Denmark
x David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
k Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark
Summary
• 5 g Hagebuttenpulver am Tag reduzieren signifikant die
Objective: Meta-analysis of randomized controlled trials (RCTs) e of a hip powder of Rosa canina (rosehip) preparation for symptomatic
treatment of osteoarthritis (OA), in order to estimate the empirical efficacy as a pain reducing compound.
TheSchmerzstärke übercalculatedeinen
as effect sizeZeitraum von 3-4 Monaten
Method: RCTs from systematic searches were included if they explicitly stated that OA patients were randomized to either rosehip or placebo.
primary outcome was reduction in pain (ES), defined as the standardized mean difference (SMD). As secondary
analysis the number of responders to therapy was analyzed as Odds Ratios (OR), and expressed as the Number Needed to Treat (NNT).
Restricted Maximum Likelihood (REML) methods were applied for the meta-analyses using mixed effects models.
Results: The three studies (287 patients and a median trial-duration of 3 months) e all supported by the manufacturer (Hyben-Vital Interna-
tional) e showed a reduction in pain scores by rosehip powder (145 patients) compared to placebo (142 patients): ES of 0.37 [95% confidence
interval (CI): 0.13e0.60], P ¼ 0.002. Test for homogeneity seemed to support that the efficacy was consistent across trials (I 2 ¼ 0%). Thus it
seems reasonable to assume that the three studies were measuring the same overall effect. It seemed twice as likely that a patient allocated to
rosehip powder would respond to therapy, compared to placebo (OR ¼ 2.19; P ¼ 0.0009); corresponding to a NNT of six (95% CI: 4e13)
patients.
Conclusions: Although based on a sparse amount of data, the results of the present meta-analysis indicate that rosehip powder does reduce
© PHYSIO
pain; accordingly it may be of interest as a nutraceutical, FRANKFURT
although 2018
its efficacy and safety need evaluation and independent replication in
a future large-scale/long-term trial.Nutrition 24 (2008) 733–743
www.elsevier.com/locate/nut
Basic nutritional investigation
Consumption of hydrolyzable tannins-rich pomegranate extract
suppresses inflammation and joint damage in rheumatoid arthritis
Meenakshi Shukla, M.Sc.a, Kalpana Gupta, Ph.D.a, Zafar Rasheed, Ph.D.a,†,
Khursheed A. Khan, Ph.D.b, and Tariq M. Haqqi, Ph.D.a,*,†
a
Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio, USA
b
Department of Kulliyat, Faculty of Unani Medicine, Aligarh Muslim University, Aligarh, India
Manuscript received September 25, 2007; accepted March 12, 2008.
Abstract Objective: Although consumption of dietary supplements containing pomegranate extract (POMx)
by patients with arthritis is on the rise, the efficacy of such preparations in suppressing joint
• Im Tierversuch führt die Einnahme von Granatapfelextrakt zu
inflammation and damage is not known. The present study was designed to evaluate a standardized
preparation of POMx using collagen-induced arthritis (CIA) in mice, a widely used animal model
of rheumatoid arthritis.
einer signifikanten selteneren Erkrankung an entzündlicher
Methods: CIA-susceptible DBA/1 mice were fed POMx by gavage before and after immunization
with chicken type II collagen. Severity of clinical arthritis was scored using a visual scoring system.
Arthritis oder zumindest geringerer Schwere der Erkrankung.
Arthritic joints were analyzed by histopathology and graded. Lysates were generated from mouse
joints and levels of anti–type II collagen immunoglobulin G and inflammatory cytokines interleukin
(IL)-1!, IL-6, and tumor necrosis factor-" were quantified by enzyme-linked immunosorbent assay.
The effect of POMx on lipopolysaccharide-induced nitric oxide production was determined by
•
Griess reaction and mitogen-activated protein kinase activation was studied by western immuno-
34 mg/KG pro Tag blotting in mouse macrophages.
Results: Consumption of POMx potently delayed the onset and reduced the incidence of CIA in mice.
Severity of arthritis was also significantly lower in POMx-fed animals. Histopathology of the arthritic
joints from POMx-fed mice demonstrated reduced joint infiltration by the inflammatory cells, and the
•
destruction of bone and cartilage were alleviated. Levels of IL-6 were significantly decreased in the joints
Granatapfel aber keine Reduktion des CRP-Wertes.
of POMx-fed mice with CIA. In mouse macrophages, POMx abrogated multiple signal transduction
pathways and downstream mediators implicated in the pathogenesis of rheumatoid arthritis.
(Sahebkar et al. 2016) Conclusion: Our studies suggest that inhibition of a spectrum of signal transduction pathways and
the downstream pathogenic cellular response by POMx or compounds derived from it may be a
useful approach for the prevention of the onset and severity of inflammatory arthritis. © 2008
Elsevier Inc. All rights reserved.
Keywords: © Rheumatoid
Pomegranate; Collagen-induced arthritis; PHYSIOarthritis;
FRANKFURT 2018necrosis factor-"
Interleukin-6; TumorDOI:http://dx.doi.org/10.7314/APJCP.2013.14.11.6657
Ca a e P toc e icals it Antio i ant an Anti in a ator Potential
RESEARCH ARTICLE
Cabbage (Brassica oleracea L. var. capitata) Phytochemicals
with Antioxidant and Anti-inflammatory Potential
Sami Rokayya, Chun-Juan Li, Yan Zhao, Ying Li, Chang-Hao Sun*
Abstract
Background: The objective of this study was to investigate antioxidant and anti-inflammatory activity of
cabbage phytochemicals. Materials and Methods: Color coordinates were evaluated by colorimetry, and the
antioxidant and anti-inflammatory activities were analyzed by spectrophotometer for some common cabbage
varieties. Results: Red heads had the highest total antioxidant contents followed by Savoy, Chinese and green
heads. The Chinese variety had the highest ABTS (2,2-azino-di-(3-ethylbenzthiazoline-sulfonic acid) antioxidant
• China-, Grün- und Wirsingkohl haben die höchste
activity, was 5.72 μmol TE/g fw (Trolox equivalent). The green variety had the highest DPPH (free radical
scavenging activity) antioxidant activity, which was 91.2 μmol TE/g fw. The red variety had the highest FRAP
potenzielle antiinflammatorische Wirkung, gefolgt von
(ferric reducing antioxidant power) antioxidant activity, which was 80.8 μmol TE/g fw. The total phenol amounts
were 17.2–32.6 mM trolox equivalent antioxidant capacity (TEAC) and the total flavonoid amounts were 40.0–74.2
Rotkohl.
mg quercetin per gram. Methanolic extracts of different cabbage heads showed different anti-inflammatory
activity values. Chinese, Savoy and green heads had the highest anti-inflammatory activity, while red heads had
the lowest. Conclusions: The results suggest that these varieties of cabbage heads could contribute as sources of
important antioxidant and anti-inflammatory related to the prevention of chronic diseases associated to oxidative
stress, such as in cancer and coronary artery disease.
Keywords: Cabbage head - antioxidant - anti-inflammatory - cell
Asian Pac J Cancer Prev, 14 (11), 6657-6662
Introduction © PHYSIO FRANKFURT
healing 2018
peptic ulcers (Cheney, 1949), and facilitatingDOI:http://dx.doi.org/10.7314/APJCP.2013.14.11.6657
Ca a e P toc e icals it Antio i ant an Anti in a ator Potential
RESEARCH ARTICLE
Cabbage (Brassica oleracea L. var. capitata) Phytochemicals
with Antioxidant and Anti-inflammatory Potential
Sami Rokayya, Chun-Juan Li, Yan Zhao, Ying Li, Chang-Hao Sun*
Abstract
Background: The objective of this study was to investigate antioxidant and anti-inflammatory activity of
cabbage phytochemicals. Materials and Methods: Color coordinates were evaluated by colorimetry, and the
antioxidant and anti-inflammatory activities were analyzed by spectrophotometer for some common cabbage
varieties. Results: Red heads had the highest total antioxidant contents followed by Savoy, Chinese and green
heads. The Chinese variety had the highest ABTS (2,2-azino-di-(3-ethylbenzthiazoline-sulfonic acid) antioxidant
• China-, Grün- und Wirsingkohl haben unter den Kohlarten
activity, was 5.72 μmol TE/g fw (Trolox equivalent). The green variety had the highest DPPH (free radical
scavenging activity) antioxidant activity, which was 91.2 μmol TE/g fw. The red variety had the highest FRAP
die höchste potenzielle antiinflammatorische Wirkung,
(ferric reducing antioxidant power) antioxidant activity, which was 80.8 μmol TE/g fw. The total phenol amounts
were 17.2–32.6 mM trolox equivalent antioxidant capacity (TEAC) and the total flavonoid amounts were 40.0–74.2
gefolgt von Rotkohl.
mg quercetin per gram. Methanolic extracts of different cabbage heads showed different anti-inflammatory
activity values. Chinese, Savoy and green heads had the highest anti-inflammatory activity, while red heads had
the lowest. Conclusions: The results suggest that these varieties of cabbage heads could contribute as sources of
important antioxidant and anti-inflammatory related to the prevention of chronic diseases associated to oxidative
stress, such as in cancer and coronary artery disease.
Keywords: Cabbage head - antioxidant - anti-inflammatory - cell
Asian Pac J Cancer Prev, 14 (11), 6657-6662
Introduction © PHYSIO FRANKFURT
healing 2018
peptic ulcers (Cheney, 1949), and facilitatingWeitere antiinflammatorische Lebensmittel
• Nüsse • Ackerschachtelhalm • Äpfel
• Wildkräuter • Pinienrinde • Zimt
• Beeren • Teufelskralle • Chili
• Früchte • Dinkel • Hering/Matjes
• Salate • Urkorn • Kakao
• Sprossen (Brokkoli) • Braunhirse • Weidenrinde
• Steinpilze • Brennessel
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